Patents Issued in March 16, 2017
  • Publication number: 20170073271
    Abstract: A gypsum hardened body including a gypsum slurry that has been hardened is provided. The gypsum slurry is obtained by mixing calcined gypsum, calcium hydrogen phosphate dihydrate, water, and foam. The specific gravity of the gypsum hardened body is greater than or equal to 0.3 and less than or equal to 0.8.
    Type: Application
    Filed: May 23, 2014
    Publication date: March 16, 2017
    Inventors: Ushio SUDO, Hiroaki ITANO, Yosuke SATO, Tomoaki SAWADA
  • Publication number: 20170073272
    Abstract: Disclosed are product (e.g., panels), slurry, and methods relating to a pregelatinized starch having a mid-range viscosity (i.e., from about 20 centipoise to about 700 centipoise), and an extruded pregelatinized starch.
    Type: Application
    Filed: November 22, 2016
    Publication date: March 16, 2017
    Inventors: Yijun SANG, Chris C. LEE, Cesar CHAN, Weixin David SONG
  • Publication number: 20170073273
    Abstract: Disclosed herein are settable compositions and methods of using settable compositions in a wellbore. In one embodiment a method of introducing a settable composition into a wellbore is described. The method comprises providing a settable composition comprising pumice, hydrated lime, a set retarder, and water. Introducing the settable composition into a wellbore. Allowing the settable composition to remain static in the wellbore, wherein the settable composition remains in a pumpable fluid state for a period of about 1 day or longer while static in the wellbore.
    Type: Application
    Filed: November 28, 2016
    Publication date: March 16, 2017
    Applicant: Halliburton Energy Services, Inc.
    Inventors: Kyriacos Agapiou, Juan Humberto Martinez, Thomas Jason Pisklak, Vivek S. Goel, Lance Everett Brothers, Benjamin John Iverson
  • Publication number: 20170073274
    Abstract: A fly ash composition including fly ash and a plasticizing agent and being in a powder form is disclosed. The plasticizing agent is capable of binding the fly ash particles in the fly ash composition together on pressing of the fly ash composition. Processes of forming shaped articles containing fly ash may utilize the fly ash composition and/or mixtures containing fly ash and have low water content and may exhibit sufficient green strength to be handled by industrial equipment.
    Type: Application
    Filed: November 29, 2016
    Publication date: March 16, 2017
    Applicants: NEWSOUTH INNOVATIONS PTY LIMITED, VECOR IP HOLDINGS LIMITED
    Inventor: Sandor Koszo
  • Publication number: 20170073275
    Abstract: The present disclosure relates to a composite of sintered mullite reinforced corundum granules and a method for its preparation. The composite comprises mullite and corundum in an interlocking microstructure. The process for preparing the composite involves the steps of admixing the raw materials followed by sintering to obtain the composite comprising sintered mullite reinforced corundum granules.
    Type: Application
    Filed: October 19, 2015
    Publication date: March 16, 2017
    Inventors: Chetan Navnitlal Shah, Manan Chetan Shah, Amit Chatterjee, Anurag Tilak
  • Publication number: 20170073276
    Abstract: A method for making transparent nanocomposite ceramics and other solid bulk materials from nanoparticle powders and transparent nanocomposite ceramics and other solid bulk materials formed using that method. A nanoparticle powder is placed into a reaction chamber and is treated to produce a clean surface powder. The clean surface powder is coated with a second material by means of p-ALD to produce core/shell or core multi shell nanoparticles having a coating or coatings of a other material surrounding the nanoparticle. The core/shell nanoparticles are cleaned and formed into green compact which is sintered to produce a transparent nanocomposite ceramic or other solid bulk material consisting of nanoparticles or core/shell nanoparticles uniformly embedded in a matrix of a different material, particularly in a matrix of a different ceramic material, formed by outer shell of initial core/shell. All steps are performed without exposing the material to the ambient.
    Type: Application
    Filed: September 9, 2016
    Publication date: March 16, 2017
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Boris N. Feigelson, James A. Wollmershauser, Kedar Manandhar, Francis J. Kub
  • Publication number: 20170073277
    Abstract: In some examples, a method may include depositing, from a slurry comprising particles including silicon metal, a bond coat precursor layer including the particles comprising silicon metal directly on a ceramic matrix composite substrate. The method also may include locally heating the bond coat precursor layer to form a bond coat comprising silicon metal. Additionally, the method may include forming a protective coating on the bond coat. In some examples, an article may include a ceramic matrix composite substrate, a bond coat directly on the substrate, and a protective coating on the bond coat. The bond coat may include silicon metal and a metal comprising at least one of Zr, Y, Yb, Hf, Ti, Al, Cr, Mo, Nb, Ta, or a rare earth metal.
    Type: Application
    Filed: September 9, 2016
    Publication date: March 16, 2017
    Inventors: Sungbo Shim, Kang N. Lee, Stephen Isaiah Harris, Andrew Joseph Lazur
  • Publication number: 20170073278
    Abstract: In some examples, method including forming an EBC layer on a substrate, wherein the EBC layer exhibits an initial porosity; forming a layer of silicate glass on a surface of the EBC layer; and melting the silicate glass on the surface of the EBC layer to infiltrate the EBC layer with the molten silicate glass to decrease the porosity of the EBC layer from the initial porosity to a final porosity.
    Type: Application
    Filed: September 14, 2016
    Publication date: March 16, 2017
    Inventors: Sean E. Landwehr, Adam Lee Chamberlain, Ann Bolcavage
  • Publication number: 20170073279
    Abstract: A facility secondary NO3? salinized soil modifier and a modification method are disclosed. The present invention involves the preparation processes of two biological soil modifiers A and B and application methods thereof, which are specifically described as follows: (1) soil modifier A.: solid, obtained by microbial fermentation with straw powder and rice bran and the like as raw materials. C/N between 30-50, applied by uniformly mixing at 1-1.4% by mass with facility ploughing soil, co-culturing at 35-50° C. for 5-7 days, and then returning to fields; and (2) soil modifier B: liquid, subjected to salt tolerance acclimation to have effective microbial populations, and used in the crop growth period. Based on the microbial techniques, the present invention can improve soil structureness, enhance microbial activity and promote biological immobilization on inorganic nitrogen in soils, significantly increasing the facility cultivation crop yield, and improving the product quality.
    Type: Application
    Filed: June 19, 2014
    Publication date: March 16, 2017
    Applicant: HOHAI UNIVERSITY
    Inventors: Tingting Chang, Xiaohou Shao, Huilian Xu, Weina Wang, Lihua Chen, Xinyu Mao, Chunfang Wang
  • Publication number: 20170073280
    Abstract: A hybrid rocket solid fuel grain having a cylindrical shape and defining a center port is additive manufactured from a compound of thermoplastic fuel and passivated nanocomposite aluminum additive. The fuel grain comprises a stack of fused layers, each formed as a plurality of fused abutting concentric circular beaded structures of different radii arrayed defining a center port. During operation, an oxidizer is introduced along the center port, with combustion occurring along the exposed port wall. Each circular beaded structure possesses geometry that increases the surface area available for combustion. As each layer ablates the next abutting layer, exhibiting a similar geometry is revealed, undergoes a gas phase change, and ablates. This process repeats and persists until oxidizer flow is terminated or the fuel grain material is exhausted. To safety achieve this construction, a fused deposition additive manufacturing apparatus, modified to shield the nanocomposite material from the atmosphere is used.
    Type: Application
    Filed: September 25, 2016
    Publication date: March 16, 2017
    Inventor: Ronald D. Jones
  • Publication number: 20170073281
    Abstract: A composite reactive material for use in a munition is disclosed. The composite reactive material comprises a metal lattice structure having interstitial spaces and a powder in the interstitial spaces. The powder comprises at least one metal powder and/or at least one halogen-containing polymer powder.
    Type: Application
    Filed: May 1, 2015
    Publication date: March 16, 2017
    Applicant: MBDA UK LIMITED
    Inventors: Terence Alan ACKERMAN, David Robert CROFTS, Kiran GULIA, Moataz Mohammad Mahmoud ATTALLAH, Jack Robert Harry MELLOR
  • Publication number: 20170073282
    Abstract: A nanoenergetic material composite having a remote ignition characteristic by a high-power pulsed laser beam is prepared by adding various contents of multiwalled carbon nanotubes (MWCNTs) to a nanoenergetic composite material (nEM) to enable remote ignition by a high-power laser beam. The nanoenergetic material composite is a MWCNT/nEM composite powder prepared by adding multiwalled carbon nanotubes to the nanoenergetic material, which is a mixture of fuel material nanoparticles and metal oxidizer nanoparticles, wherein the multiwalled carbon nanotubes enhance a combustion rate of the MWCNT/nEM composite powder by delivering thermal energy upon remote optical ignition by the high-power pulsed laser beam.
    Type: Application
    Filed: November 23, 2016
    Publication date: March 16, 2017
    Applicant: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
    Inventors: Soo Hyung KIM, Ji Hoon KIM
  • Publication number: 20170073283
    Abstract: The present disclosure addresses the deficiencies described above by providing systems and methods for enhancing the efficiency and yield of alkene production. The methods and systems provide for the use of activated CO2 in a dehydrogenation reactor along with an alkane stream. Through the use of the methods and systems of the invention, catalyst deactivation by coke deposition is reduced and the selectivity and efficiency of the dehydrogenation reaction is improved.
    Type: Application
    Filed: May 5, 2015
    Publication date: March 16, 2017
    Applicant: Sabic Global Technologies B.V.
    Inventors: YongMan Choi, Adel Abdullah Al-Ghamdi, Ramsey Bunama, Khalid M. El-Yahyaoui
  • Publication number: 20170073284
    Abstract: The present invention relates to a catalyst for the dehydrogenation of hydrocarbons which is based on iron oxide and a process for producing it. The catalyst comprises at least one iron compound, at least one potassium compound and from 11 to 24% by weight of at least one cerium compound, calculated as CeO2, wherein the at least one iron compound and the at least one potassium compound are at least partly present in the form of one or more K/Fe mixed oxide phases of the general formula KxFeyOz, where x is from 1 to 17; y is from 1 to 22 and z is from 2 to 34, and comprises at least 50% by weight, based on the total catalyst, of the K/Fe mixed oxide phases, and also a process for producing it.
    Type: Application
    Filed: May 6, 2015
    Publication date: March 16, 2017
    Inventors: FLORINA C. PATCAS, Martin DIETERLE
  • Publication number: 20170073285
    Abstract: This present disclosure relates to processes and apparatuses for toluene methylation in an aromatics complex for producing paraxylene. More specifically, the present disclosure relates to processes and apparatuses wherein a toluene methylation zone is integrated within an aromatics complex for producing paraxylene thus allowing no benzene byproduct to be produced. This may be accomplished by incorporating a toluene methylation process into the aromatics complex and recycling the benzene to the transalkylation unit the aromatics complex.
    Type: Application
    Filed: October 16, 2015
    Publication date: March 16, 2017
    Inventors: Patrick C. Whitchurch, Gregory R. Werba
  • Publication number: 20170073286
    Abstract: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.
    Type: Application
    Filed: September 23, 2016
    Publication date: March 16, 2017
    Inventors: Jean-Louis H. Dasseux, Carmen D. Oniciu
  • Publication number: 20170073287
    Abstract: A process for the manufacture of terphenyl compounds comprising reacting at least one compound of general formula (I) with at least one cyclic compound and wherein the process is carried out in the presence of a mixture which contains at least one Lewis acid, optionally, at least one thio compound of formula R—S—R? and at least one co-catalyst compound selected from the group consisting of C1-C10 alkanols, C1-C10 amides, C1-C10 ethers and C1-C10 amines; and wherein the ratio of the total molar amount of Lewis acid and co-catalyst compound to the molar amount of compound (C) is equal to or above 5:1 and equal to or below 20:1 and the molar ratio co-catalyst compound to Lewis acid is equal to or above 0.01:1.
    Type: Application
    Filed: March 11, 2015
    Publication date: March 16, 2017
    Applicant: SOLVAY SPECIALTY POLYMERS USA, LLC
    Inventor: Chantal LOUIS
  • Publication number: 20170073288
    Abstract: The compound according to the present invention is represented by a specific formula. The compound according to the present invention has a structure according to the specific formula, and therefore can be applied to a wet process and is excellent in heat resistance and etching resistance. In addition, the compound according to the present invention has such a specific structure, and therefore has a high heat resistance, a relatively high carbon concentration, a relatively low oxygen concentration and also a high solvent solubility. Therefore, the compound according to the present invention can be used to form an underlayer film whose degradation is suppressed at high-temperature baking and which is also excellent in etching resistance to oxygen plasma etching or the like. Furthermore, the compound is also excellent in adhesiveness with a resist layer and therefore can form an excellent resist pattern.
    Type: Application
    Filed: March 13, 2015
    Publication date: March 16, 2017
    Inventors: Takashi MAKINOSHIMA, Masatoshi ECHIGO
  • Publication number: 20170073289
    Abstract: The present invention provides, among other things, new processes for separating and purifying C4 fractions from a crude C4 stream. Compared to prior methods, the processes of the present invention simplify the C4 separation processes, afford more possible configurations for separation and purification, and are more cost effective. The processes and systems provided herein can be used as part of a cost-effective and efficient method for synthesizing methyl tertiary-butyl ether.
    Type: Application
    Filed: May 7, 2015
    Publication date: March 16, 2017
    Inventors: Guillermo Leal, Zeeshan Nawaz, Renaat Hennus, Antonio Matarredona, Faisal Baksh
  • Publication number: 20170073290
    Abstract: A compound having formula C{Ph(R1)i(OR2)j}2{Ph(R3)m(OR4)n}{Ph(R5)o(OR6)p}, wherein Ph represents a benzene ring, R1, R3 and R5 independently are C1-C18 alkyl or C4-C18 heteroalkyl; R2, R4 and R6 independently are C1-C18 alkyl or C4-C18 heteroalkyl, i, j, m, n, o and p independently are zero, one or two.
    Type: Application
    Filed: April 21, 2015
    Publication date: March 16, 2017
    Applicant: Rohm and Haas Company
    Inventors: George David Green, Warren E. Smith, Raymond J. Swedo
  • Publication number: 20170073291
    Abstract: Disclosed herein are methods for selective synthesis of specific phenolic products by means biomass or biomass products liquefaction, manipulation of the said selectivity in favor of one specific phenolic compound or a mixture of specific phenolic compounds, and the synthesis of the phenolic compounds from a liquid or biomass organic fraction produced in presence of a homogeneous catalyst in supercritical state or a mixture of said homogeneous and one or several heterogeneous catalysts mixed with water in sub-critical, near-critical, or supercritical condition.
    Type: Application
    Filed: September 12, 2016
    Publication date: March 16, 2017
    Applicant: South Dakota Board of Regents
    Inventors: Alevtina Smirnova, Chris Lynde, Abu Md Numan-Al-Mobin, Rudresh Bommadihalli Rajappagowda
  • Publication number: 20170073292
    Abstract: Providing a catalytic process for preparing 1,4-diketone compounds from furanic compounds and their precursors in a liquid medium, using an acid catalytic system and optionally in the presence of hydrogen and a hydrogenation catalyst, wherein the acidic catalytic system comprises a solid acid catalyst or a mixture of water and CO2.
    Type: Application
    Filed: February 28, 2014
    Publication date: March 16, 2017
    Inventors: Floryan DE CAMPO, Jean-Marc CLACENS, Francois JEROME, Karine DE OLIVEIRA VIGIER, Fei LIU
  • Publication number: 20170073293
    Abstract: The invention describes processes to convert biomass char, such as levulinic acid process char, into useful products.
    Type: Application
    Filed: March 2, 2015
    Publication date: March 16, 2017
    Inventors: Brian D. Mullen, Erich J. Molitor, Alan K. Schrock
  • Publication number: 20170073294
    Abstract: The present disclosure relates to catalytic conversion of ketoacids, including methods for increasing the molecular weight of ketoacids, the method including the steps of providing in a reactor a feedstock comprising at least one ketoacid. The feedstock is then subjected to one or more C—C-coupling reaction(s) in the presence of hydrogen, and in the presence of a catalyst system having both hydrogenation activity and C—C-coupling activity.
    Type: Application
    Filed: September 26, 2016
    Publication date: March 16, 2017
    Applicant: NESTE OYJ
    Inventors: Jukka MYLLYOJA, Rami PIILOLA
  • Publication number: 20170073295
    Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.
    Type: Application
    Filed: November 23, 2016
    Publication date: March 16, 2017
    Applicant: UNITED THERAPEUTICS CORPORATION
    Inventors: HITESH BATRA, VIJAY SHARMA, SANMIN YANG, YI ZHANG
  • Publication number: 20170073296
    Abstract: Zinc or copper (II) salt which can be used as a biocide, having the general formula CH2C(R1)CO—M—OCOR2(OH)m(COOH)n wherein M is Zn or Cu, R1 is selected from the group comprising hydrogen and methyl, R2 is substituted C1-C5 alkyl, m=0-5, n=0-2, m+n=1-5.
    Type: Application
    Filed: November 28, 2016
    Publication date: March 16, 2017
    Inventors: Igor I. ZOTKIN, Nadezhda V. KUZNETSOVA, Larisa V. KABANOVA
  • Publication number: 20170073297
    Abstract: Disclosed is a method for production of a methyl ester based formulation. The method involves: providing a feedstock containing about 1% to about 100% canola oil; removing water from the feedstock; heating the feedstock to at least about 60° C.; mixing a solution of about 90% to about 100% (v/v) methanol and a strong base with the heated feedstock to produce a mixture containing methyl ester; and allowing the mixture containing methyl ester to rest for at least one hour. The composition of the methanol and strong base solution being calculated based on the free fatty acid content of the feedstock. The methyl ester based formulations produced by the method can be used as ecofriendly penetrating oils, lubricating oils, machining fluid or releasing agents.
    Type: Application
    Filed: September 16, 2016
    Publication date: March 16, 2017
    Inventors: BILL BETOURNEY, VIKTORIA MCLEA
  • Publication number: 20170073298
    Abstract: The present application discloses novel amino-sulfide metal catalysts for organic chemical syntheses including hydrogenation (reduction) of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, oils and fats, resulting in alcohols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for a variety of chemicals.
    Type: Application
    Filed: October 6, 2016
    Publication date: March 16, 2017
    Inventors: Dmitri Goussev, Denis Spasyuk, Samantha Smith
  • Publication number: 20170073299
    Abstract: The invention concerns a method for producing diaryl carbonates from monophenols and phosgene or chloroformic acid aryl esters in the presence of an optionally substituted pyridine or the hydrochloride salt thereof as catalyst, and the recovery and reinjection thereof back into the method. The method is carried out at least partially in a liquid phase without the use of an additional solvent, the catalyst being separated by means of crystallization and recovered.
    Type: Application
    Filed: May 5, 2015
    Publication date: March 16, 2017
    Inventors: Karl-Heinz Köhler, Ricarda Leiberich, Kaspar Hallenberger, Korbinian Krämer, Florian Lipski, Henning Kahnis, Gabriel Denecker, Johan Vanden Eynde, Weerachanan Somhom
  • Publication number: 20170073300
    Abstract: The invention concerns a method for producing diaryl carbonates from monophenols and phosgene or chloroformic acid aryl esters in the presence of at least one optionally substituted pyridine or the hydrochloride salt thereof as catalyst, and the recovery and reinjection thereof back into the method. The method is carried out at least partially in a liquid phase without the use of an additional solvent, the catalyst being separated by means of distillation and recovered.
    Type: Application
    Filed: May 4, 2015
    Publication date: March 16, 2017
    Inventors: Karl-Heinz Köhler, Ricarda Leiberich, Kaspar Hallenberger, Korbinian Krämer, Florian Lipski, Henning Kahnis, Gabriel Denecker, Johan Vanden Eynde, Weerachanan Somhom
  • Publication number: 20170073301
    Abstract: Methacrylated cardanol glycidyl ethers, diglycidyl ethers, intermediates and derivatives thereof are described herein. Compositions and polymers made with such compounds as well as methods of preparation thereof are also described. For example, compounds of Formulas: wherein n, R1, R2, R3, R4, R5, and R6 can each represent various different entities are described in the present disclosure.
    Type: Application
    Filed: May 1, 2015
    Publication date: March 16, 2017
    Inventors: Dominic THIBEAULT, François ROUILLARD, Steve CARRIER, Pascal VUILLAUME
  • Publication number: 20170073302
    Abstract: The present invention provides a one-pot method for synthesizing clomiphene (a mixture of the isomers cis-clomiphene and trans-clomiphene) utilizing a single solvent. In a preferred embodiment, the single solvent is dichloromethane (DCM, also known as methylene chloride). The present invention provides an improved method for synthesizing clomiphene and purifying clomiphene isomers.
    Type: Application
    Filed: March 9, 2015
    Publication date: March 16, 2017
    Applicant: REPROS THERAPEUTICS INC.
    Inventors: Joseph S. PODOLSKI, Kuang HSU
  • Publication number: 20170073303
    Abstract: A solvent medium for diazotization reaction includes a mixed solution of polyethylene glycol and water. The molecular weight of polyethylene glycol is 200-600, and the volume ratio of polyethylene glycol and water is 1:0.4-1.5. The mixed solution also includes hydrochloric acid or sulfuric acid, and the concentration of H+ in the mixed solution is 0.32-1.72 mol L?1.
    Type: Application
    Filed: June 25, 2014
    Publication date: March 16, 2017
    Inventors: Jiajie LONG, Xiaochen WEI, Ming SHEN
  • Publication number: 20170073304
    Abstract: The present invention relates to a method for preparation of Teriflunomide, comprising steps of: (a) adding Leflunomide to an alcoholic solvent to give solution (I); (b) adding an aqueous sodium hydroxide solution slowly into the solution (I) to give solution (II); (c) acidifying the solution (II) with inorganic acid for precipitation to give solution (III); and (d) filtering the solution (III) to give Teriflunomide.
    Type: Application
    Filed: September 10, 2015
    Publication date: March 16, 2017
    Applicant: FORMOSA LABORATORIES INC.
    Inventors: CHING-PENG WEI, PEI-CHEN HUANG
  • Publication number: 20170073305
    Abstract: The invention relates to fatty acid amides; compositions comprising an effective amount of a fatty acid amide; and methods for treating or preventing cancer, a metabolic disease or a neurodegenerative disease comprising the administration of an effective amount of a fatty acid amide.
    Type: Application
    Filed: August 22, 2016
    Publication date: March 16, 2017
    Inventors: Jill C. Milne, Michael R. Jirousek, Jean E. Bemis, Chi B. Vu, Amal Ting
  • Publication number: 20170073306
    Abstract: Inhibitors of carbonic anhydrase-II derived from sulfanilamide are reported.
    Type: Application
    Filed: September 15, 2015
    Publication date: March 16, 2017
    Inventors: Muhammad Iqbal Choudhary, Muhammad Saleem, Aamer Saeed Bhatti, Atia-tul Wahab, Ajmal Khan, Atta-ur- Rahman
  • Publication number: 20170073307
    Abstract: (S)-4-hydroxy-2-oxo-1-pyrrolidine crystal form III (called crystal form III of (S)-oxiracetam for short) has diffraction peaks at diffraction angles 2?, wherein the diffraction angles 2? are equal to 10.54, 13.70, 14.44, 15.60, 17.12, 18.88, 19.24, 20.66, 20.84, 21.18, 21.82, 22.94, 23.24, 24.88, 27.20, 27.48, 28.24, 30.46, 30.80, 31.52, 32.00, 32.34, 32.90, 33.20, 34.40, 34.62, 37.30, 37.50, 38.28, 38.96, and 40.02°. The (S)-oxiracetam crystal form III of the present invention has an obvious effect on memory dysfunction, is dissolved in water fast, has high bioavailability, and can be used to prepare various pharmaceutical compositions. The (S)-oxiracetam crystal form III obtained by using the preparation method of the present invention is high in purity. The preparation method of the present invention is performed in a mild condition, is easy in operation, introduces less impurities, has desirable reproducibility, is easily controlled during production, and is applicable to industrial production.
    Type: Application
    Filed: October 27, 2014
    Publication date: March 16, 2017
    Inventor: Lei YE
  • Publication number: 20170073308
    Abstract: Provided herein are methods and compositions for controlling auxin responses in plants.
    Type: Application
    Filed: September 13, 2016
    Publication date: March 16, 2017
    Inventor: Paul Brian Larsen
  • Publication number: 20170073309
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: November 22, 2016
    Publication date: March 16, 2017
    Inventors: Philip Stewart TURNBULL, Rodolfo CADILLA
  • Publication number: 20170073310
    Abstract: A photopolymerizable material contains, as a main polymerization component, a bicarbazole compound represented by structural formula (1). In structural formula (1), X1 and X2 are each independently a photopolymerizable functional group, a structural site having a photopolymerizable functional group, or a hydrogen atom, at least one of X1 and X2 is a photopolymerizable functional group or a structural site having a photopolymerizable functional group, R1 and R2 are each independently a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a bromine atom, or a chlorine atom, and at least one of R1 and R2 is a hydrogen atom.
    Type: Application
    Filed: April 30, 2014
    Publication date: March 16, 2017
    Inventors: Changjun Deng, Masanori Miyamoto, Nobuo Kobayashi, Xia Yang
  • Publication number: 20170073311
    Abstract: The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., Pd(II)-, Ni(II)-, or Fe(II)-ligand of Formula (A)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers Y. The provided supramolecular complexes are able to form gels (e.g., hydrogels). The gels are suprametallogels and exhibited excellent mechanical properties without sacrificing self-healing and showed high robustness and storage modulus. The present disclosure further provides compositions (e.g., gels) that include the nanostructures or supramolecular complexes and optionally an agent (e.g., small molecule), where the nanostructures and the nanostructure moieties of the supramolecular complexes may encapsulate and slowly release the agent.
    Type: Application
    Filed: September 20, 2016
    Publication date: March 16, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Jeremiah A. Johnson, Niels Holten-Andersen, Scott Charles Grindy, Ken Kawamoto, Aleksandr V. Zhukhovitskiy
  • Publication number: 20170073312
    Abstract: A method for producing a compound represented by formula (I) comprises the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of trifluoroacetic acid as an acylating agent to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B), as follows
    Type: Application
    Filed: March 4, 2015
    Publication date: March 16, 2017
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Nozomu NAKANISHI, Shigeki KITSUDA, Yoshimasa FUKUDA
  • Publication number: 20170073313
    Abstract: The invention provides compounds as represented by Formula I or I? and pharmaceutically acceptable salts, solvates, and diastereomers thereof: Wherein R1, R2, R2a, R3, and R4 are defined in the disclosure. The invention also provides compounds of Formulae II, III, and A-H, and pharmaceutically acceptable salts, solvates, and diastereomers thereof. In certain embodiments, Compounds of the Invention are useful for treating pain, constipation, and other conditions as delineated in the disclosure. Without wishing to be bound by any theory, it is believed that Compounds of the Invention are effective in treating conditions that are modulated by activity of opioid and/or ORL-1 receptors.
    Type: Application
    Filed: May 5, 2015
    Publication date: March 16, 2017
    Inventors: Laykea Tafesse, Jiangchao Yao, Jianming Yu, R. Richard Goehring
  • Publication number: 20170073314
    Abstract: Disclosed are compounds of formula I as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also disclosed are pharmaceutical compositions comprising at least one such compound, and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.
    Type: Application
    Filed: March 9, 2015
    Publication date: March 16, 2017
    Inventors: Pravin L. Kotian, Yarlagadda S. Badu, Minwan Wu, Venkat R. Chintareddy, V. Satish Kumar, Weihe Zhang
  • Publication number: 20170073315
    Abstract: The present invention relates to the novel regioselective syntheses of 2,4-disubstituted pyrimidines through sequential nucleophilic aromatic substitutions.
    Type: Application
    Filed: November 22, 2016
    Publication date: March 16, 2017
    Inventors: Jean-Damien Charrier, Michael Edward O'Donnell
  • Publication number: 20170073316
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Application
    Filed: August 25, 2016
    Publication date: March 16, 2017
    Applicant: Dow AgroSciences LLC
    Inventors: Gary D. Crouse, Lindsey G. Horty, Erich W. Baum, Thomas C. Sparks
  • Publication number: 20170073317
    Abstract: The isocyanate composition consists essentially of an isocyanurate derivative of 1,3-xylylenediisocyanate, the isocyanurate derivative is modified with aliphatic alcohol, and the modification amount of the aliphatic alcohol is 0.5 mass % or more and 15 mass % or less.
    Type: Application
    Filed: March 3, 2015
    Publication date: March 16, 2017
    Inventors: Kazuyuki FUKUDA, Hideaki OTSUKA, Tsutomu YOSHIDA, Tatsuya NAKASHIMA, Toshiaki MORIYA, Shirou HONMA
  • Publication number: 20170073318
    Abstract: The present application relates to novel heterocyclic compounds, to the use thereof for controlling animal pests including arthropods, insects and nematodes, and to processes and intermediates for preparation of the novel compounds.
    Type: Application
    Filed: March 4, 2015
    Publication date: March 16, 2017
    Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Eike Kevin HEILMANN, Heinz-Juergen WROBLOWSKY, Axel TRAUTWEIN, Joerg GREUL, Hardwin DEMBSKI, Kerstin ILG, Daniela PORTZ, Ulrich GOERGENS
  • Publication number: 20170073319
    Abstract: The present invention relates to a compound of formula (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein R1, R2, R3, L1, L2, L3, L4, L5 and n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, and/or protein misfolding disorders.
    Type: Application
    Filed: March 17, 2015
    Publication date: March 16, 2017
    Applicant: REMYND NV
    Inventors: Gerard GRIFFIOEN, Bart DE TAEYE, Katrien PRINCEN, Koen DE WITTE, Emilie BLANCHE, Hasane RATNI, Matthias NETTEKOVEN, Mark ROGERS-EVANS
  • Publication number: 20170073320
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
    Type: Application
    Filed: September 21, 2016
    Publication date: March 16, 2017
    Inventors: Justin S. CISAR, Cheryl A. GRICE, Todd K. JONES, Micah J. NIPHAKIS, Jae Won CHANG, Kenneth M. LUM, Benjamin F. CRAVATT