Abstract: The present invention concerns human antibodies recognising the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based on the role of C5a and its receptor in stimulation of inflammation the invention further relates to therapeutic use of said human anti-C5aR antibodies and in particular in relation to treatment of immunological disorders.

Abstract: Provided herein, in one aspect, are antibodies that immunospecifically bind to a human KIT antigen comprising the fourth and/or fifth extracellular Ig-like domains (that is, D4 and/or D5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit KIT activity, such as ligand-induced receptor phosphorylation. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to a KIT antigen, as well as methods of treating or managing a KIT-mediated disorder or disease and methods of diagnosing a KIT-mediated disorder or disease using the antibodies described herein.

Abstract: The present invention relates to a method to engineer immune cell for immunotherapy. In particular said immune cells are engineered with chimeric antigen receptors, which be activated by the combination of hypoxia and ligand extracellular binding as input signals. The invention also relates to new designed chimeric antigen receptors which are able to redirect immune cell specificity and reactivity toward a selected target exploiting the ligand-binding domain properties and the hypoxia condition. The present invention also relates to cells obtained by the present method, in particular T-cells, comprising said chimeric antigen receptors for use in cancer treatments.

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

Abstract: This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and have the ability in the alternative to become internalized by cells expressing folate receptor alpha (FRA) and to induce an immune effector activity such as antibody-dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to FRA-expressing cells as well as in eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to nucleotides encoding the antibodies of the invention, cells expressing the antibodies; methods of detecting cancer cells; and methods of treating cancer using the antibodies.

Abstract: A method is provided for determining the efficacy of GPC3-targeting drug therapy for cancer in a patient before the start of GPC3-targeting drug therapy or for determining the continuation of GPC3-targeting drug therapy for a patient treated with GPC3-targeting therapy. The method includes determining the number of an immunocyte or an expression level of a molecule expressed on the immunocyte in a biological sample isolated from the patient before the start of GPC3-targeting drug therapy and/or the patient treated with the GPC3-targeting drug therapy, wherein when the number of the immunocyte or the expression level of the molecule expressed on the immunocyte is a predetermined value, the efficacy of the GPC3-targeting drug therapy is determined or the continuation of the GPC3-targeting drug therapy is determined. GPC3-targeting drugs and drug preparations for use according to the disclosed methods are also provided.

Abstract: The present invention provides a novel class of antibodies and antigen binding fragments thereof that bind the extracellular domain of ErbB3 receptor and inhibit various ErbB3 functions. For example, the antibodies and antigen binding fragments described herein are capable of binding to the receptor designated ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor. Such antibodies and antigen binding fragments thereof have the useful characteristic of inhibiting the proliferation of cancer cells expressing ErbB3.

Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.

Abstract: It has been established that cancer cells with oncogenic mutants in the small GTPase K-Ras are susceptible to antibodies that bind intracellular guanosine, but delivery of antibodies into cells can be challenging. A subset of lupus autoantibodies is associated with anti-guanosine activity, and is capable of cellular penetration. These antibodies have potential as therapeutic agents targeted towards K-Ras associated malignancies.

Abstract: The invention discloses novel anti-RNF43 antibodies and derivatives thereof, including antibody drug conjugates, and methods of using such anti-RNF43 antibodies and antibody drug conjugates to diagnose and treat cancer.

Abstract: The present invention comprises a humanized monoclonal antibody that binds to the human immunoglobulin heavy chain variable region germline gene VH1-69. This antibody is derived from Mab G6 and recognizes the same epitope. Moreover, the antibody is used in combination with vaccines to augment an immune response to the antigen.

Abstract: The present disclosure relates to therapies for the treatment of tumor, autoimmune diseases, or other diseases. In some embodiments, the present disclosure can relate to subject-specific selection of humanized antibodies targeting clonal lineage specific marker proteins.

Abstract: Described herein are processes to produce polygalacturonic acids from pectin containing products, said process involving (a) optionally washing pectin containing products, (b) optionally injecting dry steam into pectin containing products [and maintaining a temperature of about 140° to about 160° C. under pressure at about 40 to about 60 psi for a time period of between about 0.5 to about 3 minutes, (c) optionally heating pectin containing products to above about 70° C. to about 95° C. or optionally cooling to less than about 10° C.

Abstract: A method for grafting a carboxylic acid ester function onto an unsaturated polymer, which comprises the reaction of a 1,3-dipolar compound with at least one unsaturation of the unsaturated polymer is provided. The 1,3-dipolar compound comprises a group Q and a group B connected to one another by a group A in which: Q comprises a dipole containing at least and preferably one nitrogen atom, B represents a carboxylic acid ester function, A, which is preferably divalent, is an atom or a group of atoms connecting Q to B.

Abstract: A process is provided for the polymerization of fluoromonomer to an dispersion of fluoropolymer particles in an aqueous medium in a polymerization reactor, by (a) providing the aqueous medium in the reactor, (b) adding the fluoromonomer to the reactor, (c) adding initiator to the aqueous medium, the combination of steps (b) and (c) being carried out essentially free of hydrocarbon-containing surfactant and resulting in the kickoff of the polymerization of the fluoromonomer, and (d) metering hydrocarbon-containing surfactant into the aqueous medium after the kickoff of polymerization, e.g. after the concentration of the fluoropolymer in the aqueous medium is at least 0.6 wt %, the metering being at a rate reducing the telogenic activity of said surfactant while maintaining surface activity.

Abstract: The present invention relates to a new method of light induced photopolymerization under mild irradiation conditions, copper initiator complexes to be used in such method and a polymers obtained by such method.

Abstract: A flame retardant with which fire retardancy is improved and the fire retardancy is able to be secured stably for a long time is provided. An internal layer 11 containing a polymer and a flame retardant factor layer 12 that is formed outside of the internal layer 11 and that contains a polymer to which at least one of a sulfonate group and a sulfonate base is bonded are included. Thereby, compared to a case that the flame retardant factor layer 12 is not included, moisture is hardly absorbed, and respective particles of the flame retardant are inhibited from being adhered to each other. Accordingly, blocking is inhibited.

Abstract: The present invention provides methylene beta-ketoester monomers, methods for producing the same, and compositions and products formed therefrom. In the method for producing the methylene beta-ketoesters of the invention, a beta-ketoester is reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to further processing, which may be vaporization by contact with an energy transfer means in order to isolate the beta-ketoester monomer. The present invention further compositions and products formed from methylene beta-ketoester monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).

Abstract: An ethylene-based polymer, e.g., LDPE, with a low dissipation factor is made by a process comprising the step of contacting at polymerization conditions ethylene and, optionally, one or more comonomers, e.g., an alpha-olefin, with at least one carbon-carbon (C—C) hydrocarbyl, free-radical initiator of Structure 1: wherein R1, R2, R3, R4, R5 and R6, are each, independently, hydrogen or a hydrocarbyl group and wherein, optionally, two or more R groups (R1, R2, R3, R4, R5 and R6) form a ring structure, with the provisos that at least one of R2 and R5, and at least one of R3 and R6 is a hydrocarbyl group of at least two carbon atoms, e.g., an alkaryl of at least seven carbon atoms.

Abstract: A slurry polymerization process comprising polymerizing monomers in a reactor comprising baffles, a first slurry feed line for returning cooled slurry from a cooler and optionally a second slurry feed line for transferring reactor slurry from a previous reactor of a cascade of polymerization reactors, wherein the baffle top, the first slurry feed line discharge end and the second slurry feed line end are located below the reactor liquid level.

Abstract: The present invention provides a catalyst component for olefin polymerization, obtained by a reaction of magnesium, titanium, halogen and an internal electron donor, the internal electron donor comprising an imine compound as shown in Formula Z. The present invention also provides a preparation method of the catalyst component, and a catalyst for olefin polymerization containing the same. When the catalyst of the present invention is used for olefin polymerization reaction, the catalyst has a high activity, and a slow rate of activity decay, and the obtained polymer has a high isotacticity index, and a wide molecular weight distribution.

Abstract: Novel antiviral means is disclosed. The antiviral agent of the present invention comprises as an effective ingredient particles having a particle diameter of not more than 5 ?m, wherein said particles are polymer particles whose repeat unit comprises a structure represented by a particular general formula, and wherein said particles do not contain an antiviral active component. The polymer particles are preferably cyanoacrylate polymer particles. The antiviral agent of the present invention shows adhesiveness to the surface (especially envelope) of virus particles, and destroys a normal virus particle structure to reduce or eliminate infectivity of the virus particles. Sanitary articles such as masks comprising the antiviral agent of the present invention can exert an excellent effect on prevention of infection with viruses such as influenza virus that occurs through droplet infection or airborne infection.

Abstract: A method for producing a polydiene, the method comprising the steps of (i) forming an active catalyst by combining a lanthanide-containing compound, an alkylating agent, and a halogen source; and (ii) polymerizing conjugated diene monomer in the presence of the active catalyst and a catechol compound.

Abstract: The present disclosure relates to propylene-ethylene copolymers comprising an ethylene content of 0.1-10% by weight, a molecular weight distribution (MWD), expressed in terms of Mw/Mn, of greater than 3.0 and a xylene soluble (XS) fraction content defined by values that fall below the line given by the equation XS=1.0296·e0.435C2. The propylene-ethylene copolymers advantageously exhibit high transparency and low melting temperatures.

Abstract: A photopolymerizable composition, which contains: a monofunctional monomer having a viscosity of 5 mPa·s or less at 25° C.; one or more polyfunctional monomers including glycerol dimethacrylate; and a polymer free from a hydrophilic functional group, wherein a mass ratio (A/B) of an amount (A) of the polymer free from a hydrophilic functional group to an amount (B) of the polyfunctional monomer is greater than 0.80 but 3 or less.

Abstract: The present invention relates to a copolymer obtainable by copolymerization of at least three ethylenically unsaturated monomers each different from one another, the copolymer having at least three structural units (S1) and (S2) and (S3) different from one another, to the use of this copolymer as an adhesion-promoting additive in an aqueous coating composition, to an aqueous coating composition comprising at least one polymeric resin (A1), at least one pigment (B), and at least one copolymer of the invention, used as adhesion-promoting additive, as component (C), and also to methods for at least partly coating a substrate with a basecoat and for at least partly coating a substrate with a multicoat paint system.

Abstract: The present invention provides polymers containing an acetoacetate moiety. The polymers may be readily functionalized and the functionalized polymers may be further derivatized to provide a wide variety of useful polymers having desirable chemical and physical properties. The polymers of the present invention may be employed in a wide variety of compositions, wherein R1-R6, w, y, and z are described herein.

Abstract: An atactic polypropylene comb-block polyolefin comprising two blocks including a polyolefin backbone and atactic polypropylene combs pendant to the backbone having a weight average molecular weight of at least 8000 g/mole and a crystallinity of less than 20%, where the atactic polypropylene comb-block polyolefin has comb number of at least 2. The atactic polypropylene comb-block polyolefin is made by contacting at a temperature within a range from 20 to 70° C. propylene with a first metallocene precursor to form vinyl-terminated atactic polypropylene to form vinyl-terminated atactic polypropylene, then contacting at a temperature within a range from 40 to 150° C. the vinyl-terminated atactic polypropylene with ethylene, propylene, or both and a second metallocene precursor to form the backbone.

Abstract: A block copolymer, in particular for use as a dispersant for mineral binder compositions, including at least one first block A and at least one second block B, wherein the first block A has a monomer unit M1 and the second block B has a monomer unit M2. To this end a proportion of monomer units M2 which is in any case present in the first block A is less than 25 mol %, in particular less than or equal to 10 mol %, based on all the monomer units M1 in the first block A and a proportion of monomer units M1 which is in any case present in the second block B is less than 25 mol %, in particular less than or equal to 10 mol %, based on all the monomer units M2 in the second block B.

Abstract: A multiblock copolymer, obtainable by copolymerization of a conjugated diene compound and a non-conjugated olefin, is characterized in that: a structure of the multiblock copolymer includes A-(B-A)x and/or B-(A-B)x, wherein “A” represents a block portion constituted of monomer units of a non-conjugated olefin, “B” represents a block portion constituted of monomer units of a conjugated diene compound, and “x” represents an integer ?1; content of the non-conjugated olefin portion is 50 mol %; 0 mol % <crystal content of the non-conjugated olefin portion 20 mol %; and 0% <degree of crystallinity of the non-conjugated olefin portion 40%. Vulcanized rubber having high fracture resistance and high crack resistance (thus a rubber composition and a tire each using the vulcanized rubber and having such excellent physical properties) can be manufactured from the multiblock polymer.

Abstract: A process for producing a polyacetal copolymer, the process making catalyst deactivation easy and efficient. Trioxane as a major monomer is copolymerized with one or more comonomers that are a cyclic ether and/or cyclic formal having at least one carbon-carbon bond, using a nonvolatile protonic acid as a polymerization catalyst at 100° C. or lower until the conversion reaches 50% and thereafter at a polymerization environment temperature of 115° C. to 140° C. This process includes: a crushing step in which a dry-process crusher is used to obtain a crude polyacetal copolymer crushed to such a degree that when the crude copolymer is screened with a sieve having an opening size of 11.2 mm, 90 parts by weight or more thereof passes therethrough; and a deactivation step in which a basic compound (e) is added to the crude copolymer and the mixture is melt-kneaded to thereby deactivate the polymerization catalyst.

Abstract: Self-immolative polymers degrade by an end-to-end depolymerization mechanism in response to the cleavage of a stabilizing end-cap from the polymer terminus. Examples include homopolymers, mixed polymers including block copolymers, suitable for a variety of applications. A polyglyoxylate can be end-capped or capped with a linker as in a block copolymer.

Abstract: Polymeric reaction products of certain aromatic alcohols with certain aromatic aldehydes are useful as underlayers in semiconductor manufacturing processes.

Abstract: The present invention relates to a two-component polyurethane composition composed of at least one polyol, at least one polyisocyanate, and at least one emulsifier which is not homogeneously miscible with the at least one polyol. The present invention further relates to the use of this polyurethane composition as a binder for producing fiber composites, a method for producing these fiber composites, the fiber composites themselves, and use thereof.

Abstract: A polyurethane composite element has one or more gaps containing a polyurethane foam. The polyurethane foam has a density of 16-40 kg/m3 and a closed cell proportion of 50-90% determined according to ASTM D6226-2010 Standard Test Method. The polyurethane foam is formed by applying a polyurethane composition into the gaps in situ. A process for producing a polyurethane composite element is also described.

Abstract: The purpose of the present invention is to provide: a polishing pad having a high polishing rate and excellent planarizing properties; and a method for producing the polishing pad. A polishing pad which has a polishing layer comprising a polyurethane resin foam, said polishing pad being characterized in that a polyurethane resin, which is a material used for forming the polyurethane resin foam, has an alkoxysilyl group represented by general formula (1) in a side chain thereof. (In the formula, X represents OR1 or OH; and R1's independently represent an alkyl group having 1 to 4 carbon atoms.

Abstract: The purpose of the present invention is to provide a silicone-modified epoxy resin which produces a cured product having excellent low gas permeability and strength; a composition of the resin; and an epoxy resin cured product obtainable by curing the composition. Disclosed is an epoxy resin represented by the following Formula (1): wherein R1 independently represents a monovalent aromatic hydrocarbon group having 6 to 12 carbon atoms; R2 independently represents a monovalent aliphatic hydrocarbon group having 1 to 12 carbon atoms; R3 independently represents a monovalent aliphatic hydrocarbon group having 1 to 12 carbon atoms or a monovalent aromatic hydrocarbon group having 6 to 12 carbon atoms; R4 represents an oxygen atom or a divalent hydrocarbon group having an aliphatic cyclic structure; R5 represents silicone chain having a norbornane epoxy structure at either end; and X represents an organic group having a norbornane epoxy group.

Abstract: A novel byproduct compound having the following chemical formula B: wherein R is hydrogen or CH3; a composition including an admixture of: (A) a product having the following chemical formula A: wherein R is hydrogen or CH3; and (B) the above novel byproduct compound having the chemical formula B; and a composition including a reaction product of: (a) an aromatic epoxy resin; (b) hydrogen; (c) a catalyst; and (d) a solvent; wherein the reaction product produced is a cycloaliphatic epoxy resin admixture of the combination of (i) the above product having the chemical formula A and (ii) the novel byproduct compound having the chemical formula B; wherein the above product having the chemical formula A includes at least a cis-cis isomer, a cis-trans isomer, and a trans-trans isomer; and the novel byproduct compound having the chemical formula B includes at least a cis isomer and a trans isomer.

Abstract: A resin composition containing (A) an epoxy resin; (B) a compound represented by formula (1) below; (C) a curing accelerator; and (D) a silane coupling agent is provided. The compound of the (B) component has a content of 1:0.5 to 1:2.5, in terms of an equivalent ratio between epoxy groups in the epoxy resin of the (A) component and thiol groups in the compound of the (B) component, the silane coupling agent of the (D) component has a content of 0.2 parts by mass to 50 parts by mass with respect to 100 parts by mass in total of the (A) component, the (B) component, the (C) component, and the (D) component, and an equivalent ratio between thiol groups in the compound of the (B) component and Si in the silane coupling agent of the (D) is 1:0.002 to 1:1.

Abstract: Polyether ketone compounds obtained by reacting a compound represented by formula (1): wherein R1, XD, YDc, and nDc are defined herein, with a compound represented by formula (2): wherein Xe, Ye, Ze, and ne are defined herein, exhibit high thermal resistance.

Abstract: The invention is generally directed to sports bottles and other articles produced by blow molding from polymeric materials containing isosorbide having glass transition temperatures ranging from 90° C. to 130° C., as well as to processes for producing them. These articles can be exposed to water at high tempeatures and can be produced by using a suitable combination of a stretch ratio of less than 3× and a preform temperature at least 20° C. greater than the glass transition temperature (Tg) of the polymeric material.

Abstract: A polyester including poly(ethylene 2,5-furandicarboxylate is prepared by esterification of a starting mixture including 2,5-furandicarboxylic acid and ethylene glycol to form an ester composition, and by subjecting the ester composition thus obtained to polycondensation at reduced pressure in the presence of a polycondensation catalyst to obtain a polycondensate. The mixture is reacted under conditions such that the esterification potential as defined by Esterification Potential (EsPo)=(MR?1)2*PH2O(T), where MR represents the molar ratio of ethylene glycol over 2,5-furandicarboxylic acid, MR being greater than 1; PH2O(T) represents the pure component vapor pressure (in bar) of water at temperature T, which is the final reaction temperature in the esterification mixture before the pressure is reduced to effect the polycondensation, is less than 0.8.

Abstract: In one aspect, the present invention provides catalysts for the carbonylation of heterocycles. The inventive catalysts feature metal-ligand complexes having cationic functional groups tethered to the ligand, wherein the tethered cationic groups are associated with anionic metal carbonyl species. The invention also provides methods of using the inventive catalysts to affect the ring opening carbonylation of epoxides.

Abstract: Disclosed are a method for preparing a modified biodegradable polymer by using various additives and plasticizers in a biodegradable polymer which is non-toxic to human bodies, a biodegradable polymer prepared therefrom, and a biodegradable stent prepared by using the biodegradable polymer. Specifically, it is possible to reduce a decrease in molecular weight resulting from a thermal degradation occurring during the solid-phase molding processing of a biodegradable polymer by coating a solution in which various additives are dissolved during the modification of the biodegradable polymer to convert the hydroxyl end group into a functional group of a carboxylic group or a different kind of hydroxyl group.

Abstract: The present invention provides a sustained release composition having hyperbranched polymers that are polyesters that are biobased and biodegradable, and that have at least one active ingredient, which composition delivers the active ingredient over time. These active ingredients can be a wide variety of compounds so long as they can covalently bind to the polymer or be encapsulated in the polymer in a manner that is released at the point of delivery, usually by acid hydrolysis or enzymatic bond scission.

Abstract: The present invention relates to a method for producing a polycarbonate diol, comprising subjecting a compound represented by the following formula (A) containing from 0.01 to 1.0 wt % of an aldehyde derivative, a compound represented by the following formula (B), and a carbonate compound to polycondensation by a transesterification reaction in the presence of a catalyst to produce a polycarbonate diol having a number average molecular weight of 250 to 5,000: HO—(CH2)10—OH??(A) HO—R1—OH??(B) wherein in the formula (B), R1 represents a substituted or unsubstituted divalent alkylene group having a carbon number of 3 to 20, wherein the compound of the formula (A) is not included by the formula (B).

Abstract: Copolymer comprising polyarylene ether blocks and hydrophilic-hydrophobic blocks, wherein said hydrophilic-hydrophobic blocks comprise polyisobutene blocks.

Abstract: The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents.

Abstract: A method for producing a polyamide, comprising performing melt polycondensation of a diamine component comprising xylylenediamine in an amount of 70 mol % or more and a dicarboxylic acid component comprising a linear aliphatic dicarboxylic acid having 6 to 18 carbon atoms in an amount of 70 mol % or more in the presence of a phosphorus atom-containing compound (A), wherein the decomposition temperature of the phosphorus atom-containing compound (A) is not lower than the melting point of the polyamide, and an aqueous solution of the phosphorus atom-containing compound (A) and the diamine component are added to the dicarboxylic acid component being in a molten state to perform the melt polycondensation.

Abstract: The invention relates to a copolyamide comprising at least two units corresponding to the following general formula: A/10,T in which: A is chosen from a unit obtained from an amino acid, a unit obtained from a lactam and a unit corresponding to the formula (Ca diamine).(Cb (cyclo)aliphatic diacid), with a representing the number of carbon atoms of the diamine and b representing the number of carbon atoms of the diacid, a and b each being between 4 and 36; 10,T denotes a unit obtained from the polycondensation of 1,10-decanediamine and terephthalic acid, characterized in that it has a polydispersity index, denoted by Ip, of less than or equal to 3.5, measured by gel permeation chromatography. The invention also relates to the process for preparing said copolyamide, a composition comprising this polyamide and also the use of this polyamide and of such a composition.