Abstract: This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.

Abstract: A method of manufacturing a conical-projections-sheet packaging body includes forming a plurality of conical-recess parts on a conical-projections forming sheet; forming, by supplying a conical-projections material to the conical-projections forming sheet, a conical-projections sheet including a base sheet and a plurality of conical projections formed on a surface of the base sheet and disposed inside the plurality of conical-recess parts; forming a plurality of sets of the conical-projections forming sheets and the conical-projections sheets by punching out the conical-projections forming sheets and the conical-projections sheets; and using a package member to package a set of the conical-projections sheets and the conical-projections forming sheets tightly adhered to one another. Thus, the plurality of conical projections of the conical-projections sheet are protected.

Abstract: A transdermal patch and a microneedle sheet can efficiently introduce a target substance to the stratum corneum and prevent a reduction in the protection capability of the stratum corneum. A microneedle sheet comprises a sheet-shaped base material and a plurality of microneedles on the sheet-shaped base material making contact with a stratum corneum of a skin. Each of the plurality of microneedles includes a skin-stretching part projecting from the sheet-shaped base material, the skin-stretching part having a tip surface configured to stretch the stratum corneum by pressing against the surface of the stratum corneum of the skin without sticking into the surface of the stratum corneum. A needlelike-projection part is formed on the tip surface of the skin-stretching part having a shape such that the needlelike-projection part sticks into the surface of the stratum corneum and a peak part of the needlelike-projection part stays inside the stratum corneum.

Abstract: A Luer medical connector having a male Luer body for connection with a female Luer assembly which includes a female Luer body, a fluid channel insert within the female Luer body, an elastomeric seal between the female Luer body and the male Luer body, and an elastomeric stopper at a proximal end of the female Luer body.

Abstract: A medical valve which is able to more reliably support an outer peripheral part of an elastic valve body with respect to a housing, and prevent a problem of the elastic valve body becoming dislodged inward. A medical valve includes an elastic valve body with annular grooves formed thereon and a tubular support part formed at an outer peripheral side of an annular joining part positioned between the annular grooves. Inside and outside holding parts engage the annular grooves provided to the valve inside and outside surfaces of the annular joining part. The outside holding part and inside holding part are provided to an opening member, and with the tubular support part, a part projecting inward in an axial direction is sandwiched and supported between the inside holding part and outside holding part.

Abstract: A system for facilitating resuscitation includes: a first electrode assembly having a therapy side and a first motion sensor; a second electrode assembly having a therapy side and a second motion sensor; processing circuitry operatively connected to and programmed to receive and process signals from the first and second motion sensors to estimate at least one of a chest compression depth and rate during administration of chest compressions and to compare the chest compression depth or rate to a desired range; and an output device for providing instructions to a user to administer chest compressions based on the comparison of the estimated chest compression depth or rate to the desired range. One or both of the electrode assemblies may be constructed so that the conductive therapeutic portion is able to maintain substantial conformance to the anatomy of the patient when coupled thereto.

Abstract: A peelable lid system includes a peelable lid, a seal configured to seal the peelable lid to a container, a handle coupled to the peelable lid, and a lifting mechanism coupled to handle. The lifting mechanism can be coupled to the peelable lid at a plurality of attachment points, including at least one attachment point coupled to the peelable lid away from the handle. The lifting mechanism can be configured to lift at least one portion of the peelable lid near each of the plurality of attachment points.

Abstract: A leadless pulse generator is disclosed herein. The leadless pulse generator has a body, a helical anchor, an electrode, and a sleeve. The body includes a distal end and a proximal end opposite the distal end. The helical anchor distally extends from the distal end. The electrode is at the distal end. The sleeve distally extends from the distal end and has a proximal face and a distal face opposite the proximal face. The proximal face is adjacent the body. The sleeve coaxially extends about the helical anchor and further has a biased state wherein the distal face is near a distal tip of the helical anchor. The sleeve is configured to compress such that the distal face displaces proximally towards the proximal face upon the distal face being forced against the cardiac tissue in the course of the helical anchor screwing into the cardiac tissue.

Abstract: A medical device includes a pulse generator and a filter. The pulse generator is configured to generate a stimulation signal and to provide the stimulation signal to tissue of a patient via an implantable lead assembly. The filter is configured to couple to the implantable lead assembly. A combined impedance of the implantable lead assembly and the filter with respect to a current induced by an external electro-magnetic field satisfies an impedance threshold when the external electro-magnetic field has a first frequency and when the external electro-magnetic field has a second frequency. The combined impedance has a peak impedance value when the external electro-magnetic field has a third frequency that is between the first frequency and the second frequency.

Abstract: Overvoltage protection circuitry configured to protect internal integrated circuits within an implantable device in the presence of a high voltage event such as defibrillation or electrocautery. The circuitry allows for an internal node to rise above the voltage level of the high voltage event to insure that an overvoltage protection element is triggered, even if the voltage level of the high voltage event is below the voltage trigger level of the overvoltage protection element.

Abstract: An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.

Abstract: A functional electrical stimulation system (1) for correction of drop-foot, comprising: a device (3) to be placed on a paretic leg, provided with a plurality of multi-pad electrodes (315) on one side (31), at least one of said electrodes (315) being configured to provide a stimulating electric signal on the point of the leg on which it is positioned, wherein said corresponding stimulating electric signals form a stimulation pattern; and at least one sensor (8) to be positioned on either said leg or corresponding foot, the sensor (8) being configured to, measure information during movement and emit sensor signals indicative thereof.

Abstract: One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

Abstract: An implantable medical device is provided that comprises a pulse generator circuit that times delivery of ventricular pacing pulses based on a base intracardiac interval (ICI). A processor is provided that has memory storing program instructions and storing atrial and ventricular events over multiple cardiac cycles and that is responsive to execution of the program instructions. The processor adjusts the base ICI by an ICI adjustment, during one or more of the multiple cardiac cycles, to promote intrinsic heart activity. The processor further counts a number of the cardiac cycles in which the ICI adjustments occurred in conjunction with arrhythmias to identify an excessive adjustment count and modifies the ICI adjustment to utilize a new ICI adjustment based on the excessive adjustment count.

Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level. Between titration sessions one or more parameters, such as, for example, an acclimation interval, may be adjusted based on the patient's response to the stimulation. This personalized titration process can minimize the amount of time required to complete titration so as to begin delivery of the stimulation at therapeutically desirable levels.

Abstract: A neurostimulation system comprising stimulation output circuitry configured for delivering stimulation pulses to target tissue in accordance with a set of stimulation parameters.

Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level. This titration process can minimize the amount of time required to complete titration so as to begin delivery of the stimulation at therapeutically desirable levels.

Abstract: A system and method for programming a neurostimulation device coupled to a plurality of electrodes implanted adjacent tissue of a patient are provided. A first electrode configuration corresponding to a first mode of programming the neurostimulation device is defined. A second programming mode of programming the neurostimulation device different from the first programming mode is selected. A second electrode configuration is defined based on the first electrode configuration in response to the selection of the second programming mode. The neurostimulation device is programmed using the second programming mode.

Abstract: Systems and methods are disclosed in which an external device such as a consumer mobile device (e.g., smart phone) is used as an external controller to bi-directionally communicate with an Implantable Medical Device (IMD) using a dedicated patient remote control (RC) as an intermediary device to translate communications between the two. The dedicated RC contains a graphical user interface allowing for control and monitoring of the IMD even if the mobile device is not present in the system, which is useful as a back-up should the mobile device experience problems. Use of the dedicated RC as an intermediary device broadens the utility of other computing devices to operate as an external controller for an IMD even if the computing device and IMD do not have compliant communication means.

Abstract: An example of a system for programming a neurostimulator may include a storage device and a user interface. The storage device may be configured to store waveform building blocks. The user interface may include a display screen, a user input device, and an interface control circuit. The interface control circuit may include a waveform composer configured to allow for composition of one of more building blocks and composition of a pattern of neurostimulation pulses using selected one or more waveform building blocks. The waveform composer may include a library controller and waveform building block editors. The library controller may be configured to display a library management area on the screen. The displayed library management area allows a user to manage the stored waveform building blocks. The waveform building block editors may each be configured to allow the user to compose a type of the waveform building blocks.

Abstract: In embodiments, a wearable cardiac defibrillator system includes an energy storage module configured to store a charge. Two electrodes can be configured to be applied to respective locations of a patient. One or more reservoirs can store one or more conductive fluids. Respective fluid deploying mechanisms can be configured to cause the fluids to be released from one or more of the reservoirs, which decreases the impedance at the patient location, and decreases discomfort for the patient. In some embodiments an impedance is sensed between the two electrodes, and the stored charge is delivered when the sensed impedance meets a discharge condition. In some embodiments, different fluids are released for different patient treatments. In some embodiments, fluid release is controlled to be in at least two doses, with an intervening pause.

Abstract: A pump and pump controller which uses an algorithm to quickly achieve and maintain a stable plasma field in a surgical site are provided. The algorithm calculates an electrical characteristic value to determine if the suction rate by the pump should be increased or decreased to achieve a stable plasma field. A method of using such a pump and pump controller is also provided.

Abstract: A system including a wearable cold plasma system, including a wearable cold plasma applicator configured to couple to and deliver a cold plasma to a surface of a user wearing the wearable cold plasma device.

Abstract: Apparatus and methods for treatment of a biological structure using a combination of magnetic and optical treatment. The apparatus and method for treatment may be used for aesthetic applications such as cellulite treatment, body shaping or enhancing skin appearance. The combination of these methods provides faster and enhanced effects of the treatment.

Abstract: In some cases, a frequency stimulator that can control a dosage of impulses of various low frequencies of electromagnetic waves, uses a cell phone, a tablet, a laptop, and/or any other suitable devices that produce frequencies and can supply an inductive coil that is installed in a headband of the frequency stimulator in a way to produce a low frequency electromagnetic field with the basic purpose of achieving a positive response to the frequency of the human brain that responds to a programed frequency and adjusts to it, thus creating various states of consciousness in the human head. In some cases, the power source is connected to the headband in which there is the induction coil. In some cases, the height, shape and temporal lasting of the frequency impulses is controlled by software installed in a GSM or another source of power.

Abstract: Brain stimulation methods and devices in which at least two separate magnetic pulse sources with interposed space between them are placed over two distinct brain regions. The coils are pulsed at between 1 and 100 milliseconds apart (e.g., between 5 ms and 40 ms), thereby producing neuroplastic effects upon a third brain region that is network-connected to said first and second regions.

Abstract: A neural probe for light stimulation of a tissue is provided. The probe includes a base that has light supplying circuitry, and one or more elongated microsized shanks extending from the base. Each shank has a longitudinal axis and includes one or more waveguides extending along the shank's length, with the waveguides being optically connected to the light supplying circuitry. In addition, each of the waveguides is optically connected to a diffraction grating coupler that emits a light beam from the shank when light passes from the base through the waveguide and to the diffraction grating coupler. The emitted light beam has a propagation direction at a set angle relative to an axis that is substantially normal to the longitudinal axis of the shank. A method for stimulating a tissue using the neural probe is also provided.

Abstract: An adjustable illuminator for photodynamically diagnosing or treating a surface includes a plurality of first panels and at least one second panel. The plurality of first panels have wider widths and the at least one second panel has a narrower width. The narrower width is less than the wider widths. The illuminator further includes a plurality of light sources, each mounted to one of the plurality of first panels or the at least one second panel and configured to irradiate the surface with substantially uniform intensity visible light. The plurality of first panels and the at least one second panel are rotatably connected. The at least one second panel is connected on each side to one of the plurality of first panels. The second panel acts as a “lighted hinge” to reduce or eliminate optical dead spaces between adjacent panels when the illuminator is bent into a certain configuration.

Abstract: A method for non-surgical rejuvenation of facial skin to correct both Type 1 aging changes in the epidermis layer of the skin causing visual changes in the skin and Type 2 aging changes in the dermis layer of the skin causing damage to supportive elements of the skin. The method includes the steps of exfoliation of the facial skin, stimulation of new dermal collagen deposition, removal of at least one of pigment and superficial blood vessels, relaxation of facial expression muscles, filling of soft tissue defects including at least one of deep facial lines and contour deformities, and tightening of the facial skin, and the steps of the method are applied according to a selected one of a plurality of age determined regimens.

Abstract: A brachytherapy ring applicator, kit, and method of use is provided. The brachytherapy ring applicatory includes a tandem, ring colpostat, and a bracket assembly. The tandem has a connector on a proximal end of the tandem and a treatment end on a distal end. The ring colpostat includes a ring member on a distal end of the ring colpostat. The bracket assembly is configured to be locked to both a shaft of the tandem and to a shaft of the ring colpostat such that the distal end of the tandem is firmly maintained in a fixed position relative to the distal end of the ring colpostat, and each of the tandem and the colpostat are entirely self-supporting from the bracket assembly to their distal ends.

Abstract: A computer-implemented method, a system or a non-transitory computer-readable medium of doing the same, for monitoring movement of anatomical features throughout a radiation treatment session. The method may include monitoring the movement of the anatomical features with a first modality. The method may further include obtaining positional information of the anatomical features with a second modality over a finite acquisition time. The method may also include providing an indication of a clinically relevant movement associated with the anatomical features during the finite acquisition time based on the monitored movement from the first modality.

Abstract: Provided are a respiratory guiding device (100) and method used in respiratory gated ion beam irradiation, the respiratory guiding device (100) comprising: a respiratory signal detecting unit (101), for measuring a respiratory motion trajectory curve during free breathing and deep breathing, and a real-time respiratory motion position signal in the case of guided respiration; a respiratory signal processing unit (102), for modeling free breathing and deep breathing according to an average respiratory cycle and an average respiratory amplitude calculated on the basis of the respiratory motion trajectory curve and setting a preset breath-hold time at the tail end of a function curve of a free breathing model and a deep breathing model to establish a respiratory guiding curve; a control unit (103), for adjusting the magnetic excitation cycle of a synchrotron according to the respiratory cycle represented by the respiratory guiding curve during free breathing or deep breathing, thus synchronizing the magnetic exc

Abstract: In a method and magnetic resonance apparatus for planning radiotherapy for a patient, quantitative magnetic resonance measurement data of a planning volume in the patient are acquired using a quantitative magnetic resonance method, a three-dimensional distribution of values of an electron density parameter in the planning volume are determined in a processor based on the acquired quantitative magnetic resonance measurement data, and a radiotherapy plan is calculated using the three-dimensional distribution of the values of the electron density parameter.

Abstract: A collimator for a radiotherapy apparatus comprising a block of radiation-attenuating material having a front face forming the leading edge of the block and at least one main rear face defining the trailing edge of the block, in which the least one main rear face has a material disposed thereon and is non-parallel to the front face. The collimator may form part of a radiotherapy apparatus, and methods of operation of such apparatus are described.

Abstract: Systems, methods, and apparatuses are provided for radiation treatment with multiple imaging elements. One system includes a first imaging element configured to generate a first observation of a first object, the first observation of the first object being generated at a first time, wherein the first object is associated with a volume of interest (VOI), wherein the VOI is a volume within a body of a patient. The system further includes a second imaging element configured to generate a first observation of a second object, wherein the first observation of the second object is generated at a second time, and the second object is associated with the VOI.

Abstract: The invention comprises a fiducial marker-fiducial detector based treatment room position determination/positioning system apparatus and method of use thereof. Generally, a set of fiducial marker detectors detect photons emitted from and/or reflected off of a set of fiducial markers positioned on one or more objects in a treatment room and resultant determined distances and/or calculated angles are used to determine relative positions of multiple objects or elements in the treatment room. Position of the mapped objects is used in: (1) imaging, such as X-ray, positron emission tomogram, and/or proton beam imaging and/or (2) beam targeting and treatment, such as proton based cancer treatment. As relative positions of objects in the treatment room are dynamically determined using the fiducial marking system, engineering and/or mathematical constraints of a treatment beamline isocenter are removed.

Abstract: Disclosed is a tumor surface dose enhancing radiotherapy apparatus using a magnetic field, including a radiation beam generating unit that irradiates a radiation beam towards a tumor of a patient, a magnetic field generating unit that forms a magnetic field that is parallel to the radiation beam between the radiation beam generating unit and the tumor of the patient, and a control unit that controls a surface dose of the tumor by adjusting an intensity and an effective area of the magnetic field of the magnetic field generating unit.

Abstract: The invention relates to a method for estimating the dose administered by an external radiotherapy system. The portal image supplied by the EPID detector is converted into a dose at a depth of reference in water, by means of a simple conversion formula. Conversely, the corresponding portal image can be determined from a distribution of a nominal dose, under the same irradiation conditions. The invention can especially be applied to the verification of a treatment plan.

Abstract: The invention relates to an apparatus for suspending a load on a suspension rope, including a body (3) provided with a means (19, 20) for hanging the load, with a stationary member (6) and with a pivotable rocker arm member (7), between which the rope (2) passes, which are capable of immobilizing the body along the rope (2) when said body tilts in a direction determined by the load. Said body is also provided with a stationary abutment (22) and with a pivotal unlocking lever (14) capable of controlling the pivotal rocker arm member (7) such as to make the latter pivot until said abutment (22) and to cause said body (3) to tilt in the opposite direction when the rocker arm member (7) is bearing against said abutment (22).

Abstract: A mask for covering areas of a wearer's face includes a mask body constructed primarily of a material that includes a cidal metal or cidal metal alloy wherein the cidal metal or cidal metal alloy is the major structural component of the mask body. The mask body covers at least a portion of the wearer's nose or mouth and nose when worn on the wearer's face. A filtering portion of the mask comprises cidal metal mesh or cidal metal alloy mesh for providing cidal action, air purification, and self-disinfection.

Abstract: A portable electronic device with a smart air purifier is provided with an electronic device body having a display surface, a back surface and a side jointed with the surfaces. The smart air purifier is embedded in the electronic device body. The smart air purifier includes a container, a fan, an air cleaning device, an air quality receiver, a tracking device, an adjustable opening, and a control panel. The container includes an air inlet formed on the back surface, an air outlet formed on the display surface, and an opening formed on the side. The fan draws air from the inlet to provide an airflow. The air cleaning device filters the airflow. The air quality receiver detects quality of the airflow. The tracking device tracks the user. The adjustable opening is disposed at the air outlet of the container. The control panel controls the fan and the adjustable opening.

Abstract: A rappelling-ascending apparatus for rock-climbing and industrial alpinism comprises an all-metal body defined by a front, a rear, and two lateral sides, a clamping element, and a handle. The body is made with a widening in its lower portion and two cuts along the lateral sides, the first being lengthwise the widening, the second being lengthwise the side and forming flanges. The handle is spring-biased and rotatably mounted on an axis between the front and rear sides. It comprises a two-prong friction fork on one side thereof relative to the axis, the friction fork being located on the side of the first cut. There is a ring on the opposite side of the handle and on the side of the second cut. The clamping element is mounted on the handle facing depressions in the flanges and adapted to hold a rope passing along the flanges when pressed against the rope.

Abstract: A passive fire response system is configured to suppress a metallic fire. The system includes a reservoir containing an ionic liquid, at least one outlet in communication with the reservoir, a valve arranged between the reservoir and the outlet, a sensor configured to sense at least one of a hydrogen concentration and a temperature and/or heat, and a controller configured to open the valve and release the ionic liquid if an output from the sensor indicates that the at least one of the hydrogen concentration and the temperature equals or exceeds at least one of a threshold hydrogen concentration and a threshold temperature.

Abstract: A fire suppression system for an aircraft (cargo) compartment comprises a source of fire suppression agent and a supply line for conducting the fire suppression agent to the compartment. The supply line comprises a pressure regulating device arranged between the source and the compartment and a pressure relief valve arranged downstream of the pressure regulating device. The pressure relief valve has an outlet which distributes the agent externally of the cargo compartment.

Abstract: An apparatus includes a flywheel, a first pivotable caliper, a first magnet supported by the first caliper opposite the flywheel, a second pivotable caliper and a second magnet supported by the second caliper opposite the flywheel. In one implementation, the apparatus further includes a first cam follower coupled to the first caliper, a second cam follower coupled to the second caliper and at least one cam member including a first cam surface against which the first cam follower moves and a second cam surface against which the second cam follower moves, wherein movement of the at least one cam member pivots the first caliper and the second caliper to move the first magnet and the second magnet relative to the flywheel. In another implementation, the apparatus further includes a strain gauge carried by the first caliper to output signals indicating braking torque.

Abstract: A fitness training apparatus is described that can include at least one pole, at least one set of one or more adjustable members, and at least one elastic member. The at least one pole can be configured to extend from at least one vicinity of at least one shoulder of a user to another at least one vicinity of a waist of the user. The at least one set of one or more adjustable members can be adjustably coupled to the at least one pole. The at least one elastic member can be configured to be adjustably coupled to the at least one set of one or more adjustable members. Related methods, techniques, articles, systems, and apparatuses are also described.

Abstract: A biceps curl machine includes: a resistance element; a user support; a first movement element comprising: a first column; and a first connecting element comprising a first pivot point such that the user support is able to pivot about a first axis associated with the first connecting element, wherein the first connecting element is movably coupled to the first column such that the first connecting element is able to move along a first path defined by the first column; and a second movement element comprising: a second column; and a second connecting element comprising a second pivot point such that the user support is able to pivot about a second axis associated with the second connecting element, wherein the second connecting element is movably coupled to the second column such that the second connecting element is able to move along a second path defined by the second column.

Abstract: A fitness set for the practice of fitness, sport, rehabilitation or physiotherapy exercises may include at least one weight, at least one shoe support for fastening the weight to a shoe of a user, and at least one body support for fastening the weight to the body of a user, the weight having a first releasable binding element and the shoe support and the body support having at least one second releasable binding element matching the first releasable binding element of the weight, configured so that that the weight may be releasably attached to the shoe support or to the body support. Methods for fitness training are also provided.

Abstract: A deadlift bar includes a rectangular frame formed by front, rear, left, and right members. The frame includes a plurality of legs spaced about the frame to establish a gap between the frame and the ground, making it easier to grip the deadlift bar once the weights are loaded onto the device. Mounted to the left and right members and extending outwardly from the frame are first and second platforms, each of which may be formed by a pair of angled protruding arms joined at their respective ends by a connecting member. The platforms also include a pair of legs at the juncture of the arms with the connecting member to support the device and prevent bowing when weights are mounted thereon. Each platform further includes a support column extending upwardly from the connecting member, vertically at its base and then at an incline extending upwardly and away from the frame.

Abstract: A mountable exercise machine is a device that is utilized to perform exercises based on elastic resistance and bodyweight. The device includes a first mounting bracket and a second mounting bracket and may be mounted to a door, wall, or similar surface or structure. A first resistance assembly and a second resistance assembly provide elastic resistance when performing exercise. The user is able to grasp a first handle and a second handle when performing upper body exercises. The first resistance assembly and the second resistance assembly may additionally include an ankle strap for performing lower body exercises. At least one harness strap may be utilized to perform suspension and other bodyweight exercises using the device. An upper door bracket and a lower door bracket allow the device to be mounted to a door instead of a wall or similar surface.