Abstract: Provided are a composition for diagnosing vascular disease including an agent measuring a level of interleukin 12 receptor ?2 protein in the blood, and a kit for diagnosing vascular disease including the same. Further, provided is a method for diagnosing vascular disease, the method including the step of measuring a level of interleukin 12 receptor ?2 protein in a blood sample separated from an individual suspected of having vascular disease. Furthermore, provided are a composition for preventing or treating vascular disease including an interleukin 12 receptor ?2 activity inhibitor, and a method of screening a therapeutic agent for vascular disease, the method including the step of treating smooth muscle cells with a test agent for vascular disease treatment and measuring an expression level of interleukin 12 receptor ?2.

Abstract: The present invention relates to, in part, methods of improved healthcare in female subjects that, for example, relay on menstrual fluid sampling for long tem biomarker monitoring.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Chitinase-3-like protein 1 as diagnostic and prognostic biomarker assays in renal injuries.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy. Also provided are kits for detecting the amount of SMN protein in a sample of cerebrospinal fluid.

Abstract: Provided are compositions and methods useful in the diagnosis of Alzheimer's Disease (AD). The methods involve immunologically testing A B biological samples for an amount of high molecular weight kininogen (HK) and cleaved high molecular weight kininogen (HKc), wherein determining less HK relative to a normal control, or determining more HKc relative to a normal control, or a combination thereof, aids in diagnosis of AD. Hybridomas and monoclonal antibodies bind with specificity to either HK alone, or to both HK and HKc. Kits for use in immunological AD testing using the mAbs are also provided.

Abstract: The invention relates to a highly sensitive method for the detection of pGlu-Abeta (pGlu-A?) peptides and the use of this method in the diagnosis of neurodegenerative diseases, such as Alzheimer's disease and Mild Cognitive Impairment. The invention further concerns a novel method for monitoring the effectiveness of a treatment of neurode-generative diseases by monitoring changes in the level of pGlu-A? peptides.

Abstract: Disclosed is a method for identifying inhibitors of the interaction of CD36 receptor and amyloid-beta protein (A?), which consists in: immobilizing CD36 on a polystyrene plate; and detecting by colorimetric, the interaction thereof with fibrillar A? (fA?), using a polyclonal anti-A? antibody and a secondary antibody conjugated to horseradish peroxidase (HRP). The inhibitors identified are potential agents for the treatment of Alzheimer's disease.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in stroke patients and in patients at risk for stroke. In particular, the invention relates to using assays that detect one or more biomarkers as diagnostic and prognostic biomarker assays in such patients.

Abstract: Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.

Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.

Abstract: The present invention relates to clinical decision support systems. In detail, the present invention relates to a method for determining the initial fibrinogen concentration in a biological sample, to the use of fibrinogen added to a biological sample in at least one predetermined concentration, to a device for determining the initial fibrinogen concentration in a biological sample, to a computer program comprising program code means for causing a computer to carry out at least several steps of the method according to the invention, to a computer readable non-transitory storage medium containing instructions for carrying out at least some steps of the method according to the invention, and to a kit for determining the initial fibrinogen concentration in a biological sample.

Abstract: A method to make it possible to obtain a value related to the amount of DD by FDP measurement.

Abstract: Method and apparatus for electronic detection and determination includes detecting a signal T0 in a detection zone and a signal R0 in a reference zone before a sample is added; adding a sample and detecting the signals in each of the detection zone and the reference zone at an interval of a second preset period; calculating a judgement value based on 2k immediately previous signals in each of the detection zone and the reference zone, the signal T0 in the detection zone before the sample is added, and the signal R0 in the reference zone before the sample is added, each time when k successive signals are detected in each of the detection zone and the reference zone; and determining a judgement result based on m successive judgement values and a preset result threshold corresponding to a current detection time.

Abstract: The present invention provides a capping system for biological thermal reaction, which comprises at least one reaction tube, at least one suction unit, and at least one pushing rod. Each of the at least one reaction tube comprises an opening end. The at least one suction unit is used to suck at least one cap and move the at least one cap to the opening end of the at least one reaction tube. The at least one pushing rob is used to push the at least one cap into the opening end of the at least one reaction tube.

Abstract: An acceleration detection device includes a piezoelectric element including a top surface and a bottom surface, a sheet-shaped adhesive provided on the bottom surface of the piezoelectric element, and a first package member to which the piezoelectric element is bonded by the sheet-shaped adhesive.

Abstract: An inertia measurement module and three-axis accelerometer, comprising a first pole piece (4) located on a substrate and a mass block (1) suspendingly connected above the substrate via elastic beams (11, 12); the elastic beams (11, 12) includes a first elastic beam (12) and a second elastic beam (11), two ends of the second elastic beams (11) being connected to an anchor point (6) of the substrate, two ends of the first elastic beam (11) being connected to the mass block (1); a center of the first elastic beam (12) and/or the second elastic beam (11) deviates from a center of gravity of the mass block (1); the mass block (1) is further provided with a first movable electrode (9) and a second movable electrode (10) in a Y-axis and an X-axis direction; the movement of one axis in a plane of the inertia measurement module cannot be affected by an eccentric structure feature, such that both X-axis movement and Y-axis movement are linear movements, thus not intensifying an inter-axis coupling, and also not reducin

Abstract: A Z-axis structure in an accelerometer comprises a mass block (1) moving relative to a substrate (4) in a Z-axis direction in a reciprocating manner. A first movable electrode plate (10) and a second movable electrode plate (11) are disposed on a sidewall of the mass block (1). A first fixed electrode plate (20) and a second fixed electrode plate (30) extending toward a plane consisting of an X axis and a Y axis are also disposed on the sidewall of the mass block (1).

Abstract: A detection device having an attached probe, the detection device including a base body (100) and a probe (200). The base body (100) is provided with a stage (140), the probe (200) is provided with a probe base body (210) and a tip (220) extending from a side surface of one end of the probe base body (210), another end of the probe base body (210) is adhered to the base body (100) via an adhesion piece (230), the probe base body (210) can be removed from the base body (100), and the tip (220) is close to the stage (140) and deployed in the direction thereof. The probe base body (210) is directly attached to the base body (100) and easily removed therefrom. It is therefore easy to replace the probe (200).

Abstract: A probe head and methods of testing a device using a probe head are provided. The probe head includes a first end connected to a first substrate. The first substrate is configured to be connected to a test head. The probe head also includes second end having a first inner recess surrounded by a first protrusion and a first plurality of probe needles connected to the first protrusion.

Abstract: A probe head that contains a coining surface and a plurality of probe tips integrated on a same side of the probe head is provided. The probe head has a first portion and a laterally adjacent second portion, wherein the first portion of the probe head contains the coining surface, and the second portion of the probe head contains the plurality of the probe tips. Each probe tip may, in some embodiments, extend outwards from a probe pedestal that is in contact with the second portion of the probe head. The probe head is traversed across the surface of a semiconductor wafer containing a plurality of solder bump arrays such that the coining surface contacts a specific array of solder bumps prior to contacting of the same specific array of solder bumps with the probe tips.

Abstract: Electrode foil (6) comprising a) an electrode layer (60) comprising—a sensing electrode portion (100), operable as an electrode of a sensing capacitor for sensing a voltage of an inner conductor (20) of a medium or high voltage power cable (10),—a first auxiliary electrode portion (200), electrically isolated from the sensing electrode portion. The electrode foil further comprises b) a non-conductive carrier film (71) carrying both the sensing electrode portion and the first auxiliary electrode portion, and c) an adhering surface portion (90) for attaching the electrode foil to an exposed insulation layer (30) of the power cable.

Abstract: A holder for a current sensor having separable portions with inner surfaces forming an opening and opposing outer surfaces having a groove to accommodate a current sensing coil. The holder includes flexible members on the portions and extending toward the opening such that the flexible members can hold a power cable substantially centered within the opening and concentric with the current sensing coil. The portions are joined together with a hinge pivotally mounted between them at one end and a releasable clasp joining them together at another end, providing for ease of installation around the power cable by hand and without requiring tools or additional fasteners.

Abstract: Transistor arrays are disclosed herein. An example transistor array includes a first node for coupling the transistor array to a circuit. A first transistor and a second transistor are coupled to the first node. A gate controller is coupled to the gate of the first transistor and the gate of the second transistor and is for selectively turning on the first transistor and the second transistor. A current source is coupled to the first node and is active when the second transistor is off. Calibration circuitry measures the voltage of the first node when the current source is active.

Abstract: The present disclosure generally describes a system that includes a heater, a power converter including a power switch, and a controller. The power converter is in communication with the heater and is operable to apply an adjustable voltage to the heater. The controller is in communication with the power switch to control the voltage output of the power converter based on at least one of a load current and a detected voltage at the heater. The controller operates the power switch to adjust the voltage output of the power converter.

Abstract: An apparatus is provided that can estimate a transfer function, for example of current measurement systems, voltage measurement systems and power measurement systems, and also provide an estimate of certainty about the transfer function. This enables customers to have confidence that they are not being overcharged for electricity.

Abstract: A system includes a first circuit and a second circuit. The first circuit includes a first MOS transistor having a gate and a drain. The first circuit is configured to receive a radio frequency (RF) signal at the gate of the first MOS transistor. The drain of the first MOS transistor is configured to output a first current that is proportional to the square of the input voltage of the RF signal while receiving the RF signal. The second circuit includes a second MOS transistor having a source configured to receive a first current from the first circuit. The second MOS transistor is biased in a triode region and has a channel resistance between the source and a drain. The second circuit is configured to output a voltage proportional to the value of the power of the RF signal received by the first circuit.

Abstract: A method and apparatus for visualizing energy flows. In one embodiment, the method comprises (I) obtaining a plurality of measured energy flow values for a plurality of energy flows between a plurality of energy sources and a plurality of energy sinks, wherein at least one of measured energy flow value is a measurement of energy flow from an energy source to two or more energy sinks; (II) computing a plurality of energy flow values based on the measured energy flow values and a set of energy priority allocation rules, wherein each computed energy flow value of the plurality of energy flow values represents energy flow between an energy source of the plurality of energy sources and an energy sink of the plurality of energy sinks; and (III) generating a display image representing at least one computed energy flow value of the plurality of energy flow values.

Abstract: A wideband digital phase meter and phase detection method are disclosed. The device measures a phase difference between 2 signals and is suitable for integration into a single MMIC. The input signals are compared digitally by using two EXOR gates and integrated over a phase comparison period. The resultant analogue signals are digitised using an Analogue to Digital convertor. Additionally, 2×D-Type registers are used to resolve the (0° to 180°) or (180° to 360°) ambiguity of the EXOR phase detector.

Abstract: A sensor for sensing a parameter includes a control circuit that outputs a clock signal, a converter that receives the clock signal, generates a parameter-dependent voltage, and outputs an output voltage based on a comparison of the parameter-dependent voltage to a reference voltage. The sensor also includes a filter that receives the output voltage and counts a number of pulses of the clock signal based on a level of the output voltage.

Abstract: An electromagnetic field quality assurance system employing an electromagnetic field generator (10) for emitting an electromagnetic field (12), and one or more quality assurance electromagnetic sensors (11, 21, 31, 41, 50) for sensing the emission of the electromagnetic field (12). The system further employs a quality assurance controller (74) for assessing a tracking quality of the electromagnetic field (12) derived from a monitoring of a sensed position of each quality assurance electromagnetic sensor (11, 21, 31, 41, 50) within a field-of-view of the electromagnetic field (12). The electromagnetic field generator (10), an ultrasound probe (20), an ultrasound stepper (30) and/or a patient table (40) may be equipped with the quality assurance electromagnetic sensor(s) (11, 21, 31, 41, 50).

Abstract: A method for analyzing noise spectrum of an electronic device includes storing a waveform data including a plurality of data points, the waveform data is obtained by measuring a target signal from the electronic device, removing data points corresponding to a background noise fluctuation based on a smooth curve of the waveform data, data points considered candidates for peaks are extracted from the waveform data, classifying the extracted data points based on a distance between adjacent data points in order to discriminate a cluster of distant data points from data points closely positioned to dominant peaks, determining the dominant peaks based on the cluster of distant data points such that the data points closely positioned to the dominant peaks are ignored, each dominant peak corresponds to the characteristic of the electronic device, and outputting the dominant peaks as an analysis result for the electronic device.

Abstract: A method for analyzing noise spectrum of an electronic device includes storing a waveform data including a plurality of data points, the waveform data is obtained by measuring a target signal from the electronic device, removing data points corresponding to a background noise fluctuation based on a smooth curve of the waveform data, data points considered candidates for peaks are extracted from the waveform data, classifying the extracted data points based on a distance between adjacent data points in order to discriminate a cluster of distant data points from data points closely positioned to dominant peaks, determining the dominant peaks based on the cluster of distant data points such that the data points closely positioned to the dominant peaks are ignored, each dominant peak corresponds to the characteristic of the electronic device, and outputting the dominant peaks as an analysis result for the electronic device.

Abstract: An electronic device according to various exemplary embodiments of the present invention may include one or more switches, one of more sub-systems, and an interface control unit electrically coupled with the one or more sub-systems and the one or more switches. The interface control unit is configured to: detect a coupling of an external device to the electronic device, identify a type of the coupled external device, when the external device is identified as a current detecting device, generate a first control signal for turning off power to the one or more sub-systems, and a second control signal for setting a first path to supply the one or more sub-systems with power from the current detecting device, and transmit the first control signal to the one or more sub-systems and the second control signal to the one or more switches.

Abstract: An electronic device including a continuity sensor and electrical circuitry configured to detect and report the continuity state of an article, container or product packaging is disclosed. The continuity sensor includes a first substrate with first and second coils thereon, and a second substrate with a third coil thereon. The first coil has an integrated circuit electrically connected thereto. The first substrate is part of, or is attached or secured to a part of the article, container or packaging. The second substrate is another part of, or is attached or secured to another part of the article, container or packaging. One of the article, container or packaging parts is (re)movable with respect to the other part. The first and second coils have one coupling when the article, container or packaging is closed or sealed, and a different coupling when the article, container or packaging is open or unsealed.

Abstract: Systems and methods for detecting thermal-mechanical strain fatigue in an electrical fuse fatigue include a controller configured to monitor at least one fuse fatigue parameter over a period of time while the fuse is connected to an energized electrical power system, and based on the monitored at least one fuse fatigue parameter, the controller is further configured to determine at least one of a consumed service life of the fuse element or a service life remaining of the fuse element.

Abstract: A partial discharge determination method and apparatus, and a partial discharge determination system capable of indicating how much margin is left before dielectric breakdown, in a lighting impulse withstand voltage test, and a power device for which whether partial discharge is caused is determined by them, and a method for manufacturing a power device including the partial discharge determination method. A low-pass filter receives an acoustic signal resulting from application of an impulse voltage and acquired by an acoustic emission sensor, and removes an electromagnetic noise superimposed on the acoustic signal. A mechanical oscillation removal unit removes a mechanical oscillation component of a device under test, from the acoustic signal resulting from application of the impulse voltage which is a high voltage, based on the mechanical oscillation component acquired in advance and included in the acoustic signal resulting from application of the impulse voltage which is a low voltage.

Abstract: A stack of series coupled transistors comprising, at least two sub-portions of the stack of series coupled transistors, and at least one logic decoder coupled to the at least two sub-portions to turn ON at least one sub-portion.

Abstract: A spark detector indicates the presence of a spark by analyzing sound waves generated when an electrical spark is produced from an electrical spark generator located on an igniter rod. The spark detector includes an acoustic sensor that is in communication with the igniter rod to determine the time for the spark sound wave to travel through the igniter rod to the acoustic sensor. If a spark is not detected, the spark detector may output a signal indicating at least one of (i) the spark was not detected, (ii) to replace the electrical spark generator immediately, or (iii) replace the electrical spark generator soon such as at the next scheduled maintenance. Furthermore, the spark detector may be calibrated based on current temperature of the igniter rod based upon time of propagation of a pulse sound wave, generated by a pulse-echo generator, to reflect off an end of the igniter rod.

Abstract: A personal laboratory includes a self-contained, miniaturized, portable kit that provides for design, testing, and automated assembling, dissembling, and reassembling of a physical system (rather than a simulation) with flexibility as to the variety of configurations of components that may be designed and assembled, and easy integration of complex components. The personal laboratory includes a reconfigurable system, the reconfigurable system includes a plurality of functional components, and a plurality of connectors configured for operatively connect respective functional components to other functional components; a stimulus generator configured to apply a stimulus to the reconfigurable system; and a measurement system configured to measure a response to the applied stimulus generated by the reconfigurable system. In the context of electronic circuits, the reconfigurable system is a reconfigurable circuit, the functional components are circuit elements and the connectors are electrical connectors.

Abstract: Systems and methods for semiconductor design evaluation. IC layout information of a circuit design is received, and the circuit design is decomposed into smaller circuit pieces. Each circuit piece has IC layout information and a netlist. For each circuit piece, a set of strike models is selected based on the layout information and the net-list of the circuit piece and received radiation environment information. Each strike model has circuit components with voltage values corresponding to a respective particle strike. For each selected strike model of a circuit piece: a radiation susceptibility metric is determined by comparing functional results of simulation of the of the strike model with functional results of simulation of the circuit piece. For each circuit piece, a radiation susceptibility metric is determined based on the radiation susceptibility metrics generated for each selected strike model of the circuit piece.

Abstract: A probe card having uniform temperature distribution under control to a desired temperature is provided, so as to provide an inspection apparatus and an inspection method. The probe card includes a supporting substrate, a wiring layer arranged including a wiring on a main surface of the supporting substrate, a probe arranged on a surface serving as an opposite side to a side of the supporting substrate of the wiring layer so as to be connected to the wiring, and a plurality of heaters. Further, the probe card is virtually divided into heater regions according to a plurality of heater regions arrayed in vertical and horizontal directions in plan view, and at least one of a plurality of heaters is arranged in each of the plurality of heater regions. An inspection apparatus is configured including the probe card, and an object to be inspected is inspected by use of the inspection apparatus.

Abstract: Probe head assemblies and probe systems for testing integrated circuit devices are disclosed herein. In one embodiment, the probe head assemblies include a contacting structure and a space transformer assembly. In another embodiment, the probe head assemblies include a contacting structure, a suspension system, a flex cable interface, and a space transformer including a space transformer body and a flex cable assembly. In another embodiment, the probe head assemblies include a contacting structure, a space transformer, and a planarization layer. In another embodiment, the probe head assemblies include a contacting structure, a space transformer, a suspension system, a platen, a printed circuit board, a first plurality of signal conductors configured to convey a first plurality of signals external to the space transformer, and a second plurality of signal conductors configured to convey a second plurality of signals via the space transformer. The probe systems include the probe head assemblies.

Abstract: A testing system includes a subtractor and a divider. The subtractor is configured to receive a first voltage of a circuit being tested and a second voltage of the circuit, and to derive a difference between the first voltage and the second voltage. The divider is configured to receive the difference between the first voltage and the second voltage, and to derive a resistance of the circuit by dividing (i) the difference between the first voltage and the second voltage by (ii) a difference between a first current applied to the circuit and a second current applied to the circuit. The first voltage is corresponding to the first current, and the second voltage is corresponding to the second current.

Abstract: Embodiments include methods, and processing system, and computer program products providing portion isolation design to a chip design to facilitate partial-good portion isolation test of the chip. Aspects include: retrieving a chip design file of a chip, the chip design file having pin related information from a chip design database, generating, via a pin group utility module, a pin group file according to the pin related information retrieved, combining, via a portion wrapper insertion utility module, the pin group file with one or more portion netlists to form one or more localized portion wrapper segments, stitching, via the portion wrapper insertion utility module, the one or more localized portion wrapper segments to form a portion boundary wrapper chain, and inserting, via the portion wrapper insertion utility module, the portion boundary wrapper chain into the chip design file to facilitate partial-good portion isolation test.

Abstract: According to an embodiment of the present invention, a computer-implemented method for testing a microelectronic chip is described. The method may include dividing, via a processor running a scanning engine, a plurality of sections of the microelectronic chip. Each of the plurality of sections includes at least two latch sets in at least one scan chain. The method may further include determining, via the processor, based on the dividing, whether each of the plurality of sections fail a data test. The determining comprises interleaving the plurality of sections by scanning, via the processor, an alternating latch set from each scan chain in a first section, and scanning an alternating latch set from each scan chain in a second section.

Abstract: A method and circuits are provided for implementing enhanced scan data testing using an XOR network to prioritize faults to be simulated during diagnostic isolation, and reducing the number of faults requiring re-simulation. A test is run, scan data are applied to scan channels using the XOR network and the output scan data are unloaded. A list of possible faults is identified based on pin flips, and the possible faults to be simulated during diagnostic isolation are prioritized by a number of occurrences in the list, and possible faults are further graded to reduce the number of possible faults requiring re-simulation.

Abstract: A method comprises a system comprising a host device coupled to a first remote device actively operating according to a state diagram that the host device and all remote devices follow during operation of the system. The method further comprises powering up a second remote device while the host device and first remote device are actively operating according to the state diagram. The second remote device waits for a synchronization point sequence. Upon detecting the synchronization point sequence, the second remote device implements a predetermined feature set and synchronizes itself to the state diagram at a common point as the host device and first remote device.

Abstract: A ZSI testing apparatus includes a fault generation circuit, a plurality of cable assemblies coupled to the fault generation circuit, wherein the cable assemblies are structured to be selectively coupled to selected circuit interrupters, a human machine interface, and a controller coupled. The controller is configured to: (i) selectively cause a fault current to be provided to a number of the cable assemblies, (ii) receive an input from each circuit interrupter that is coupled to one of the cable assemblies, each input being indicative of a trip signal output of the circuit interrupter, (iii) determine based on the received inputs (a) that an error has occurred with respect to operation of the circuit interrupters and (b) a recommendation for fixing the error, and (iv) cause an output indicative of the error and the recommendation to be provided on the human machine interface.

Abstract: Eddy current inspection of the step iron region of a generator stator core lamina insulation is performed while the rotor is in situ, with inspection system (81). The system (81) excites the stator core (26) and then measures any eddy currents indicative of a damaged region. The inspection system carriage (42) and its pivoting extension arm (52) are inserted within the rotor gap (34) while the rotor (22) remains in situ within the generator (20). The EL CID system's eddy current sensing coil assembly (54) includes a Chattock coil (70), which is mounted in a coil housing (56, 58) that is in turn pivotally mounted on a distal end of the extension arm (52). A sensing surface (60) of the coil housing (56, 58) remains in abutting contact with the generator core circumference in the step iron region (32), despite the step-like profile of the core circumference in that region.

Abstract: Accelerated testing protocols that can be utilized for determining and projecting the durability of SOFC cathodes are described. The accelerated testing protocols can be carried out under simulated operation conditions so as to provide in a matter of a few hundred hours data that can correlate to the condition of the cathode following operation of the cell over the course of a typical operation life span of several thousand hours. A testing protocol can include cycling a SOFC from OCV to operating potential at a predetermined current density. Each cycle can be relatively short, for instance less than one minute.