Patents Issued in June 21, 2018
  • Publication number: 20180171242
    Abstract: Methods and systems are disclosed for upgrading a paraffinic feed to gasoline. The system includes a fluidized cracker receiving a paraffin-containing feedstream and producing an olefin product therefrom, the olefin product comprising C4 olefins; a separation system receiving the olefinic product and separating an olefin-containing feed therefrom, the olefin-containing feed having an olefin content of at least about 10 wt %; and an oligomerization reaction system receiving the olefin-containing feed and exposing the olefin-containing feed to a conversion catalyst under first effective conversion conditions to form an oligomerized olefin effluent comprising C5+ olefinic compounds.
    Type: Application
    Filed: November 29, 2017
    Publication date: June 21, 2018
    Inventor: Mohsen N. Harandi
  • Publication number: 20180171243
    Abstract: The invention relates to a method for optimizing layered catalytic processes. This is accomplished by testing various catalysts with a compound found in a feedstock to be tested, to determine the facility of the catalyst in hydrogenating, hydrosulfurizing, or hydrodenitrogenating the molecule, and hence the feedstock. In a preferred embodiment, the Double Bond Equivalence of the feedstock and molecule are determined, and catalysts are pre-selected based upon their known ability to work with materials of this DBE value. In preferred embodiments, the layered catalysts include a demetallization catalyst, used before hydrocracking. In additional preferred embodiments, the test feedstock contains 500 ppmw or less asphaltenes, preferably C5-asphaltenes.
    Type: Application
    Filed: November 10, 2017
    Publication date: June 21, 2018
    Inventors: Omer Refa KOSEOGLU, Adnan Al-Hajji, Hendrik Muller, Masaru Ushio, Koji Nakano
  • Publication number: 20180171244
    Abstract: A method is provided for producing gasoline that includes separating a cracked naphtha feed into a light catalytic naphtha fraction and a heavy naphtha fraction; and exposing the light catalytic naphtha fraction to a catalyst under effective conversion conditions to reduce sulfur content of the light catalytic naphtha fraction while also reducing a Reid vapor pressure and an olefin content of the light catalytic naphtha fraction, wherein the effective conversion conditions comprise a pressure of less than about 500 psig and a temperature of at least about 550° F. (288° C.).
    Type: Application
    Filed: November 29, 2017
    Publication date: June 21, 2018
    Inventor: Mohsen N. Harandi
  • Publication number: 20180171245
    Abstract: Apparatuses and processes for producing at least one lubricant base oil and at least one hydrocarbon fuel range product. A deasphalted oil and a VGO stream and passed to a first hydroprocessing zone. After the first hydroprocessing zone, the hydrocarbon fuel range product may be recovered. After recovering the hydrocarbon fuel range product, the unconverted material may be separated into one or more lubricant base oil streams, and a recycle stream. The lubricant base oil streams may be upgraded, while the recycle stream may be hydroprocessed in a second hydroprocessing zone. The effluents can be combined to allow for efficient separation and recovery of the desired products.
    Type: Application
    Filed: August 24, 2017
    Publication date: June 21, 2018
    Inventor: Richard J.W. Smith
  • Publication number: 20180171246
    Abstract: An installation for the hydrotreatment and hydroconversion of hydrocarbon-containing feedstocks, with a common fractionation section, for the production of at least one of the following products: naphtha (light and/or heavy), diesel, kerosene, distillate and residue: comprising at least: at least one hydroconversion reactor, a hot high-pressure separator drum B-1, a cold high-pressure separator drum B-2, at least one hydrotreatment reactor, a cold high-pressure separator drum B-20, a common fractionation section separating a top fraction, an intermediate fraction and a heavy fraction, An integrated hydroconversion and hydrotreatment process implementing said installation.
    Type: Application
    Filed: December 20, 2017
    Publication date: June 21, 2018
    Applicant: AXENS
    Inventors: Nicolas PUPAT, Odile LAJEUNESSE, Jerome BONNARDOT, Christelle POURCELLY, Benoit DESPRES
  • Publication number: 20180171247
    Abstract: Methods are provided for dewaxing a distillate fuel boiling range feed to improve one or more cold flow properties of the distillate fuel feed, such as cloud point. The dewaxing can be performed in the presence of an olefin co-feed that allows for an increase in the average temperature for exposure of the feed to the dewaxing catalyst. If the dewaxing catalyst is included in a reactor that also includes other hydroprocessing catalyst(s), the olefin co-feed can optionally be introduced into the reactor at a location after the hydroprocessing catalyst bed(s) and prior to the dewaxing catalyst bed(s). Due to the relative ease of performing olefin saturation in the presence of a catalyst with a hydrogenation metal, a substantial portion of the olefins in an olefin co-feed (such as substantially all) can be converted to alkanes. Olefin saturation is exothermic, so the conversion of olefins to alkanes can provide a temperature increase for a feed as it is being exposed to catalyst in a catalyst bed.
    Type: Application
    Filed: December 4, 2017
    Publication date: June 21, 2018
    Inventors: Kathryn L. PERETTI, Mohsen N. Harandi
  • Publication number: 20180171248
    Abstract: A process for obtaining a wax fraction from a feed wax, the process comprising: (a) providing a molten feed wax in a container; (b) solidifying the feed wax by cooling; (c) increasing the temperature of the feed wax to a temperature at which a first fraction of the feed wax melts, said first fraction having a congealing point which is lower than the congealing point of the feed wax; (d) recovering the first fraction of the feed wax; (e) increasing the temperature of the remaining feed wax to a temperature at which a further fraction of the feed wax melts; and (f) recovering the further fraction of the feed wax. The feed wax comprises at least 75 wt.-% of linear alkanes and each recovered fraction comprises at least 19 wt.-% of the feed wax.
    Type: Application
    Filed: June 23, 2016
    Publication date: June 21, 2018
    Inventors: Gernot Meyer, Ingo Behrmann
  • Publication number: 20180171249
    Abstract: The present invention provides a method of incorporating a gaseous hydrocarbon into a liquid hydrocarbon. The method comprises steps of exposing a gaseous hydrocarbon to non-thermal plasma generated using a reduced electric field with an E/N ratio in a range of from about 10 to about 30 Td to activate the gaseous hydrocarbon, and contacting the activated gaseous hydrocarbon with the liquid hydrocarbon to incorporate the gaseous hydrocarbon into the liquid hydrocarbon. The method provides the advantages of low energy consumption and relatively low capital expenditure.
    Type: Application
    Filed: December 2, 2015
    Publication date: June 21, 2018
    Applicant: Drexel University
    Inventors: Alexander Fridman, Alexander Rabinovich, Danil Dobrynin, Ivan Chernets, Chong Liu
  • Publication number: 20180171250
    Abstract: A process for producing a substitute natural gas, the process comprising the steps of: (1) providing a synthesis gas comprising hydrogen and carbon monoxide; (2) forming a hydrogen-enriched synthesis gas; (3) subjecting the hydrogen-enriched synthesis gas to a methanation reaction to convert at least a portion of the gas into methane thereby forming a methane-enriched gas; and (4) recovering from the methane-enriched gas a methane-containing gas, wherein step (2) comprises providing a hydrogen gas and combining the hydrogen gas with the synthesis gas.
    Type: Application
    Filed: June 3, 2016
    Publication date: June 21, 2018
    Applicant: ADVANCED PLASMA POWER LIMITED
    Inventors: Chris Chapman, Massimiliano Materazzi
  • Publication number: 20180171251
    Abstract: A system and method for forming at least one of graphene and graphene oxide on a substrate and an opposed wear member. The system includes graphene and graphene oxide formed by an exfoliation process or solution processing method to dispose graphene and/or graphene oxide onto a substrate. The system further includes an opposing wear member disposed on another substrate and a gas atmosphere of an inert gas like N2, ambient, a humid atmosphere and a water solution.
    Type: Application
    Filed: January 10, 2018
    Publication date: June 21, 2018
    Applicant: UChicago Argonne, LLC
    Inventors: Anirudha V. Sumant, Ali Erdemir, Junho Choi, Diana Berman
  • Publication number: 20180171252
    Abstract: The present invention relates to the biosynthesis of ?-olefins. In particular, the invention provides methods for the production of medium-chain ?-olefins, more particularly C11 ?-olefins, using a polypeptide with decarboxylase activity on free fatty acids with 8 to 14 carbons, in particular on C8-C12 free fatty acids, more particularly on C12 free fatty acids, or a genetically engineered host cell expressing or overexpressing said polypeptide.
    Type: Application
    Filed: June 30, 2016
    Publication date: June 21, 2018
    Applicants: TOTAL RAFFINAGE CHIMIE, QINGDAO INSTITUTE OF BIOENERGY AND BIOPROCESS TECHNOLOGY (QIBEBT)
    Inventors: Laurent FOURAGE, Frédéric LAEUFFER, Henri STRUB, Yun WANG, Jian XU, Huifang HU, Shengying LI
  • Publication number: 20180171253
    Abstract: A method for preventing or reducing engine knock or pre-ignition in a high compression spark ignition engine with relatively high oil consumption, lubricated with a lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition that contains a lubricating oil base stock comprising at least one ester including at least one group selected from the group consisting of Formula (1), Formula (2), Formula (3) and Formula (4) below or at least one ester having at least 25% of its carbons in the form of methyl groups: The lubricating oils of this disclosure are useful as passenger vehicle engine oil (PVEO) products.
    Type: Application
    Filed: December 11, 2017
    Publication date: June 21, 2018
    Inventors: Zhisheng Gao, Eugine Choi, Luca Salvi, Matthew W. Boland
  • Publication number: 20180171254
    Abstract: Provided herein are estolide compositions having high oxidative stability, said compositions comprising at least one compound of formula: in which n is an integer equal to or greater than 0; m is an integer equal to or greater than 1; R1, independently for each occurrence, is selected from optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched; R2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched; and R3 and R4, independently for each occurrence, are selected from optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched. Also provided herein are uses for the compositions and methods of preparing the same.
    Type: Application
    Filed: July 20, 2017
    Publication date: June 21, 2018
    Inventors: Jakob BREDSGUARD, Travis THOMPSON, Jeremy FOREST
  • Publication number: 20180171255
    Abstract: A water-soluble metalworking fluid of the invention contains a component (A) that is a dicarboxylic acid including a sulfide structure and a component (B) that is a monocarboxylic acid, in which the fluid contains no polyalkylene glycol. A metalworking coolant of the invention is provided by diluting the above-described water-soluble metalworking fluid with water.
    Type: Application
    Filed: March 23, 2015
    Publication date: June 21, 2018
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Yosuke JIBIKI, Fumiaki TAKAGI, Tomohiko KITAMURA
  • Publication number: 20180171256
    Abstract: A grease composition comprising a thickener and a lubricating base oil, wherein the lubricating base oil has a viscosity in the range of from 5-1000 cSt (at 40° C.). The thickener is present in an amount of 5-40 wt. %, based on total weight of the grease composition. The thickener comprises an ester terminated oligomer which has the general formula: “R1-O—[CO—R2-CO—NH—R3-NH—CO—R2-CO]n-O—R1”. “R1” represents a hydrocarbon group containing 4-22 carbon atoms. “R2” represents a hydrocarbon group containing 4-42 carbon atoms. “R3” represents a hydrocarbon group containing 2-9 carbon atoms. “n” represents an integer in the range of 1-20. The weight ratio between the lubricating base oil and the ester terminated oligomer (oil/oligomer) is larger than 1. The grease composition can be used for lubricating a mechanical component having a metal surface and/or for protecting a mechanical component having a metal surface against corrosion, wear and/or fretting.
    Type: Application
    Filed: December 11, 2017
    Publication date: June 21, 2018
    Inventors: Dick Meijer, Sathwik Chatra Kalsanka Ramakrishna, Dries Muller
  • Publication number: 20180171257
    Abstract: A lubricant composition includes a base oil, an alkoxylated amide, an ester, and an anti-wear agent including phosphorus. The alkoxylated amide and ester have general formulas (I) and (II), respectively. The lubricant composition may be further defined as a racing oil composition. Also disclosed is a method for maximizing the effectiveness of a friction modifier in a racing oil composition thus increasing the fuel economy of a racing vehicle. The method includes providing the racing oil composition and lubricating an internal combustion engine of a racing vehicle to increase the fuel economy of the racing vehicle.
    Type: Application
    Filed: February 5, 2018
    Publication date: June 21, 2018
    Inventors: Eugene Scanlon, Thomas Hayden, Alfred Jung, Michael Hoey, Shaun Robert Seibel
  • Publication number: 20180171258
    Abstract: A functionalized polymer for use in a lubricant composition. The functionalized polymer includes a reaction product of a hydrocarbon polymer grafted with an acylating agent that is reacted with both: i) a hydrocarbyl substituted poly(oxyalkylene) amine and/or a poly(oxyalkylene) alcohol and ii) a polyamine. Also disclosed are a lubricating composition containing the functionalized polymer and a method of lubricating and operating an engine employing the lubricating composition that contains the functionalized polymer. The functionalized polymers may be used as viscosity modifiers and/or to provide lubricating oils have a set of properties that lead to a higher predicted fuel economy.
    Type: Application
    Filed: December 16, 2016
    Publication date: June 21, 2018
    Applicant: Afton Chemical Corporation
    Inventors: Solmaz Pirouz, Sheng Jiang
  • Publication number: 20180171259
    Abstract: The lubricating oil composition for gas engine of the present invention contains (A) a base oil, (B1) an overbased calcium salicylate, (B2) an overbased sodium sulfonate, (C1) an amine-based antioxidant, and (C2) a phenol-based antioxidant, a total content of the amine-based antioxidant (C1) and the phenol-based antioxidant (C2) being 4 mass % or more on a basis of the whole amount of the composition.
    Type: Application
    Filed: March 13, 2015
    Publication date: June 21, 2018
    Applicant: IDEMITSU KOSAN CO., LTD
    Inventor: Hirotaka YAMASAKI
  • Publication number: 20180171260
    Abstract: A grease composition comprising a lubricating base oil and a thickener, which thickener comprises an ester-terminated oligomer and a polymer. The polymer is a polyolefin. The ester-terminated oligomer has the general formula: “R1—O—[CO—R2—CO—NH—R3—NH—CO—R2—CO]n—O—R1”. “R1” each independently represent a hydrocarbon group containing 4-22 carbon atoms. “R2” represents a hydrocarbon group containing 4-42 carbon atoms. “R3” represents a hydrocarbon group containing 2-9 carbon atoms. “n” represents an integer in the range of 1-20. A method for preparing the present grease composition. The present grease composition can be used for (a) lubricating a mechanical component having a metal surface and (b) protecting a mechanical component having a metal surface against corrosion, wear and/or fretting.
    Type: Application
    Filed: December 11, 2017
    Publication date: June 21, 2018
    Inventors: Sathwik Chatra Kalsanka Ramakrishna, Dries Muller
  • Publication number: 20180171261
    Abstract: The invention concerns a threaded tubular connection for drilling or operating hydrocarbon wells, comprising a portion of a tubular element with a male end having an axis of revolution and provided with a first threading extending about the axis of revolution, said male end portion being complementary with a portion of a tubular element with a female end having an axis of revolution and provided with a second threading extending about the axis of revolution, said male and female end portions being capable of being connected by makeup, each of the male and female end portions further comprising a sealing surface with a metal-metal interference, wherein the threading and the sealing surface of one of the two, male or female, end portions are coated with a first metallic anti-corrosion and anti-galling layer wherein zinc (Zn) is the major element by weight, said first metallic anti-corrosion and anti-galling layer being coated with a first passivation layer, and the complementary threading and sealing surface of
    Type: Application
    Filed: April 21, 2016
    Publication date: June 21, 2018
    Applicants: VALLOUREC OIL AND GAS FRANCE, NIPPON STEEL & SUMITOMO METAL CORPORATION
    Inventors: Arnaud VERLEENE, Nicolas BAUDIN, Cedric VOGT, AdIL JAAFAR
  • Publication number: 20180171262
    Abstract: The present invention relates to novel compounds of general formulae (la), (lb) and (Ic) and to the stereoisomers thereof. The compounds are useful as a fragrance or as flavor as they have a sandalwood like scent. The invention also relates to a method for imparting or modifying a scent or a flavor to a composition by including said compounds into such composition, to a fragrance containing composition and/or a fragrance material containing said compound and to a process for preparing these compounds. X is C(R4)—OH or C?O; R1 is selected from the group consisting of hydrogen, C1-C4-alkyl, C2-C4-alkenyl and C3-C4-cycloalkyl, R2 is selected from the group consisting of hydrogen, C1-C4-alkyl, C2-C4-alkenyl and C3-C4-cycloalkyl, R3 is C1-C4-alkyl, R3a is selected from the group consisting of hydrogen and C1-C4-alkyl, R3b is hydrogen or together with R3a is CH2; R4 is selected from the group consisting of hydrogen and C1-C4-alkyl.
    Type: Application
    Filed: May 27, 2016
    Publication date: June 21, 2018
    Inventors: Stefan RÜDENAUER, Ralf PELZER, Vijay Narayanan SWAMINATHAN, Shrirang HINDALEKAR, Sadanand ARDEKAR
  • Publication number: 20180171263
    Abstract: The present invention relates to the novel use of a carboxylate compound as a fragrance material.
    Type: Application
    Filed: October 12, 2017
    Publication date: June 21, 2018
    Inventors: Paul D. JONES, Edward Mark ARRUDA
  • Publication number: 20180171264
    Abstract: The present invention relates to the novel use of (oxybis)dicyclohexane compounds as fragrance materials.
    Type: Application
    Filed: September 25, 2017
    Publication date: June 21, 2018
    Inventors: Paul D. JONES, Robert P. BELKO
  • Publication number: 20180171265
    Abstract: The present invention relates to novel compounds and their use as fragrance materials.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 21, 2018
    Inventors: Benjamin AMORELLI, Iyare Amegor, Michael G. MONTELEONE, Vincent COLANDREA
  • Publication number: 20180171266
    Abstract: Compositions include a water-soluble polymer, silica nanoparticles, and a combination of a nonionic and anionic dispersed in an aqueous liquid phase. The polymer is a water-soluble copolymer of acrylic acid and an acrylamide, or a salt of the same. Methods of using the compositions to clean and coat a substrate are also disclosed.
    Type: Application
    Filed: February 19, 2018
    Publication date: June 21, 2018
    Inventors: Yifan Zhang, Naiyong Jing
  • Publication number: 20180171267
    Abstract: The present invention concerns a method for laundering a textile, the use of an enzyme having DNase activity and a detergent composition comprising an enzyme having deoxyribonuclease (DNase) activity.
    Type: Application
    Filed: October 10, 2016
    Publication date: June 21, 2018
    Applicant: Novozymes A/S
    Inventor: Klaus Gori
  • Publication number: 20180171268
    Abstract: This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness. Such cold water proteases may be derived from parent enzymes, including BPN? subtilisin and subtilisin derived from Bacillus lentus, by substitution, insertion and/or deletion of one or more of the parent enzymes' amino acids.
    Type: Application
    Filed: December 13, 2017
    Publication date: June 21, 2018
    Inventors: Philip Frank Souter, Glenn Steven Ward, Viktor Yuryevich Alekseyev, Joshua Roy Basler, Luis Gustavo Cascao-Pereira, David A Estell, Ayrookaran J Poulose, James T Kellis, JR., Alexander Pisarchik, Daniel Torres-Pazmino
  • Publication number: 20180171269
    Abstract: The present invention concerns the use of a cutinase for preventing built up and/or removal of fuzz and pills, a method for laundering a textile and a detergent composition.
    Type: Application
    Filed: August 31, 2016
    Publication date: June 21, 2018
    Applicant: NOVOZYMES A/S
    Inventors: Christian Ausig Christensen, Henriette Draborg, Keith Gibson, Mette Louise Dissing Overgaard
  • Publication number: 20180171270
    Abstract: The present invention concerns a method for laundering a textile, the use of a polypeptide having DNase activity and a detergent composition comprising a polypeptide having deoxyribonuclease (DNase) activity.
    Type: Application
    Filed: June 29, 2016
    Publication date: June 21, 2018
    Applicant: NOVOZYMES A/S
    Inventor: Klaus Gori
  • Publication number: 20180171271
    Abstract: The patent application discloses the use of enzymes capable of degrading cellulosic material for removing and preventing build up of fuzz and pills and for improving the whiteness of the enzyme. Further a method for washing is disclosed.
    Type: Application
    Filed: June 23, 2016
    Publication date: June 21, 2018
    Applicant: NOVOZYMES A/S
    Inventors: Jan Peter Skagerlind, Paulo Cesar Barjona
  • Publication number: 20180171272
    Abstract: The present invention relates to co-granules comprising an enzyme and a bleach catalyst and to their use in bleach-containing granular automatic dishwash (ADW) detergents.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 21, 2018
    Applicant: Novozymes A/S
    Inventors: Lei Shang, Peter Skagerlind, Pavle Andric, Niels-Viktor Nielsen, Kaare Joergensen Engsted
  • Publication number: 20180171273
    Abstract: A fermentation monitoring system may measure the weight of a fermenting product to determine the progress of fermentation. The weight of a fermenting batch may decrease as carbon dioxide is given off, and a continuous or periodic weight measurement may be used as a control input to a fermentation system, which may adjust temperature to control fermentation or detect that fermentation is not progressing as expected. Such a system may be to use a weight scale attached to a fermentation vessel and have a control system capable of adjusting the temperature of the fermenting contents. One implementation may have a scale mounted inside a temperature controlled fermentation cabinet.
    Type: Application
    Filed: February 13, 2018
    Publication date: June 21, 2018
    Inventors: William H. Mitchell, James B. Mitchell
  • Publication number: 20180171274
    Abstract: A method for dry hopping a beverage such as young beer includes the steps of removing a portion of the beverage from the fermentation tank, mixing it with hops in a mixing vessel having a rotating paddle, and returning the young beer to the fermentation tank. A system and a mixing device are disclosed that are suitable for use with the method.
    Type: Application
    Filed: December 15, 2017
    Publication date: June 21, 2018
    Inventor: Wesley Deal
  • Publication number: 20180171275
    Abstract: An algal growth system including a first flexible sheet material mounted in a first mounted geometry such that the height is greater than the width of the first mounted geometry, and a second flexible sheet material mounted in a second mounted geometry such that the height is greater than the width of the second mounted geometry, the first flexible sheet and the second flexible sheet material being noncontiguous, a motor, the motor being coupled with an actuator system, where the motor actuates the actuator system, and a reservoir.
    Type: Application
    Filed: February 20, 2018
    Publication date: June 21, 2018
    Inventors: Zhiyou Wen, Martin Anthony Gross
  • Publication number: 20180171276
    Abstract: The present invention provides an integrated microphysiological device and fabrication methods thereof, as well as methods of use to perform biological assays.
    Type: Application
    Filed: July 1, 2016
    Publication date: June 21, 2018
    Inventors: Onur Kilic, Steven An, Andre Levchenko
  • Publication number: 20180171277
    Abstract: A method of testing an analyte can include using a cell culture device that includes: at least three distinct chambers between the top wall and bottom wall. The chambers can include: an internal chamber defined by at least one porous internal wall; one or more boundary layer chambers having at least an inner boundary layer chamber defined by the at least one porous internal wall and at least one porous inner boundary layer wall, the at least one porous internal wall having a plurality of pores fluidically coupling the central internal chamber to the one or more boundary layer chamber; and an outer chamber. The method can include: introducing a test analyte into one of the outer chamber, boundary layer chamber, or internal chamber; incubating the test analyte with one of a first cell culture, second cell culture, or third cell culture; and determining whether or not the test analyte had an effect on the first cell culture, second cell culture, or third cell culture.
    Type: Application
    Filed: February 15, 2018
    Publication date: June 21, 2018
    Inventors: Balabhaskar Prabhakarpandian, Kapil Pant
  • Publication number: 20180171278
    Abstract: The present invention is directed to provide cell concentration devices and cell concentration systems having a novel liquid flow-circulation chamber. It is a cell concentration device including a liquid flow-circulation chamber, the liquid flow-circulation chamber having a first tube and a second tube, the first tube and the second tube being connected with each other via a liquid delivery tube outside the liquid flow-circulation chamber, the liquid delivery tube including a liquid delivery pump and a cell concentration module, the liquid delivery pump being capable of feeding a liquid through the liquid delivery pump in both directions, the first tube and the second tube each having an open end in a liquid in the liquid flow-circulation chamber, the first tube having an opening in a gas in the liquid flow-circulation chamber, and the liquid being a suspension of cells.
    Type: Application
    Filed: May 9, 2016
    Publication date: June 21, 2018
    Inventors: Masaharu KIYAMA, Midori KATO, Shuhei HASHIBA, Yumiko IGARASHI
  • Publication number: 20180171279
    Abstract: Methods of protein production in continuous perfusion mammalian cell culture bioreactors are provided. Methods for continuous perfusion culture by allowing cells to self-regulate the rate of addition of perfusion medium to the bioreactor via a pH change are presented. Compositions comprising the perfusion medium as well as the process advantages of using hi-end pH control of perfusion or HIPCOP are also presented.
    Type: Application
    Filed: May 27, 2016
    Publication date: June 21, 2018
    Inventors: Gregory Walter HILLER, Matthew Paul GAGNON, Ana Maria OVALLE
  • Publication number: 20180171280
    Abstract: An vitro air-liquid interface (ALI) exposure of cultured cells makes it possible to examine the toxicological properties of the tested air. A method for evaluating effect of a polluting air stream comprises the steps of exposing cells to a membrane until adhesion of the cells has occurred, feeding cells periodically until there is a confluent monolayer of cells on said membranes, aspirating off non-adherent cells, applying fresh media, exposing the cells to over-head stream containing pollutants, removing the cells from the membranes that have been exposed to the over-head stream, then measuring the cells' response to toxins in the over-head stream.
    Type: Application
    Filed: November 22, 2017
    Publication date: June 21, 2018
    Applicant: GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE ADMINISTRATOR OF THE U.S. ENVIRONMENTAL PROTEC
    Inventors: Mark HIGUCHI, Jose ZAVALA-MENDEZ, Earl Puckett
  • Publication number: 20180171281
    Abstract: A Coriolis flow meter for measuring one or more properties of a fluid is described herein which involves a modular configuration, and includes a fluid flow sub-system and a mechanical oscillator sub-system, both functionally separate, and are coupled in a closed loop arrangement, such that the flow conduit is not directly vibrated, and instead receives induced oscillations from the mechanical oscillator sub-system. The Coriolis flow meter is useful for high purity applications, as well as for the bioprocessing applications. Bioprocessing systems incorporating the Coriolis flow meter are also described herein. Method for measuring one or more properties of a fluid using the disclosed Coriolis flow meter are also described herein.
    Type: Application
    Filed: December 20, 2016
    Publication date: June 21, 2018
    Inventors: Jens Ruetten, Philipp Lang, Charles Erklin Seeley
  • Publication number: 20180171282
    Abstract: A method of preparing Cordyceps cicadae mycelium active substances for preventing and/or treating xerophthalmia is provided. The method comprises: (a) culturing a Cordyceps cicadae mycelium in a plate media at 15 to 35° C. for 5 to 14 days; (b) inoculating the mycelium of step (a) to a flask containing liquid media and culturing it at 15 to 35° C. with a pH of 2 to 8 for 3 days; (c) inoculating the mycelium of step (b) to a fermenter tank and culturing it at 15 to 35° C. with a pH of 2 to 8 for 3 days, so as to obtain a Cordyceps cicadae mycelium fermentation liquid; (d) freeze-drying and grating the fermentation liquid, so as to obtain a Cordyceps cicadae mycelium powder; (e) extracting the powder with solvent, so as to obtain a Cordyceps cicadae mycelium extract; and (f) drying the extract, so as to obtained the Cordyceps cicadae mycelium active substances.
    Type: Application
    Filed: February 14, 2018
    Publication date: June 21, 2018
    Applicant: GRAPE KING BIO LTD.
    Inventors: Pei-Cheng LIN, Han-Hsin CHANG, Chin-Chu CHEN, Shu-Hsing YEH, Li-Ya LEE, Jui-Hsia HSU
  • Publication number: 20180171283
    Abstract: Provided are a Streptomyces (Streptomyces hygroscopicus) HS7523 and a method for preparing milbemycin A3 by culturing the Streptomyces. The Streptomyces (Streptomyces hygroscopicus) HS7523 is deposited in “China General Microbiological Culture Collection Center” with an accession number of CGMCC No. 9672 on Sep. 16, 2014.
    Type: Application
    Filed: March 25, 2016
    Publication date: June 21, 2018
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Yun Teng, Meidong Xu, Meiyi Mo, Zhihui He, Zhengjie Chen, Lianiqing Jiang, Hua Bai
  • Publication number: 20180171284
    Abstract: One embodiment provides a commensal gut production platform for ex vivo production of human gut commensal microbiota. Another embodiment provides devices, systems and methods for ex vivo culturing of gut microflora in a system that mimics the human gut environment. The culturing of the commensal microbiota in the disclosed systems produces gut microbiota having defined characteristics and properties that can be exploited to treat various conditions in a subject.
    Type: Application
    Filed: February 9, 2018
    Publication date: June 21, 2018
    Inventor: Bobban Subhadra
  • Publication number: 20180171285
    Abstract: Disclosed are methods and systems for propagating microorganisms such as yeast using a carbon source that includes glycerol and a nutrient source that includes a stillage component.
    Type: Application
    Filed: June 17, 2016
    Publication date: June 21, 2018
    Inventors: Neelakantam V. NARENDRANATH, Stephen M. LEWIS
  • Publication number: 20180171286
    Abstract: Compositions useful for propagation of pluripotent stem cells are provided. The compositions comprise a polysaccharide hydrogel linked to a peptide fragment of the extracellular domain of epithelial cadherin. Methods of making the composition, and culturing pluripotent stem cells also are provided.
    Type: Application
    Filed: December 14, 2017
    Publication date: June 21, 2018
    Inventors: Ipsita Banerjee, Prashant Kumta, Thomas Richardson
  • Publication number: 20180171287
    Abstract: This disclosure relates to methods of detecting and quantifying low concentrations of cells in a sample with targeted nanoparticles having Raman reporters using surface-enhanced Raman scattering for detection. In certain embodiments, the sample is a group of cells derived from stem cells that have been differentiated into specific cell types and one is detecting residual stem cells or other progeny in order to quantify the purity of the sample. In certain embodiments, the targeted nanoparticles contain two or more Raman reporters for the purpose of multiplexing. In certain embodiments, purity measurements are used to make quality control determinations.
    Type: Application
    Filed: June 17, 2016
    Publication date: June 21, 2018
    Inventors: Chunhui Xu, Shuming Nie, Jingjia Han
  • Publication number: 20180171288
    Abstract: Compositions and methods of treating a subject with cancer are described. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound with the dual characteristics or restoring function of the c-Cbl ubiquitin ligase in cancer cells and in also worsening sublethal lysosomal dysfunction, preferably in combination with an agent capable of making cancer cells more oxidized. The pharmaceutical composition can be administered with an additional therapeutic agent or agents such as an agent that represents an accepted standard of care for the treatment of a particular type being treated. The methods can be used for treating a wide variety of different kinds of cancers, such as brain tumors, breast cancers, melanomas, breast cancers and lymphomas.
    Type: Application
    Filed: November 21, 2017
    Publication date: June 21, 2018
    Inventors: Mark Noble, Brett Stevens, Hsing-Yu Chen, Jennifer Stripay, Christopher Folts, Nicole Scott
  • Publication number: 20180171289
    Abstract: A pick-and-place system for plant embryos includes a tray for receiving a suspension of plant embryos. The tray is movable to repeatedly reposition the plant embryos. An identification system is proximate the tray for identifying a target plant embryo amongst the plant embryos in the suspension. The identification system is configured to identify the target plant embryo while the tray is moving. A robotic arm is proximate the tray and is in communication with the identification system. The robotic arm is actuatable to pick the target plant embryo out of the suspension while the tray is moving, and deposit the target plant embryo at a target location.
    Type: Application
    Filed: December 19, 2017
    Publication date: June 21, 2018
    Inventors: Gregory W. Adams, Andrew W. McCartney, John F. Lawless, John Aikens, Chris Davenport
  • Publication number: 20180171290
    Abstract: The present invention provides a method of producing progenitor cells, such as cells capable of being differentiated into a plurality of different cell types, from differentiated cells. Methods of using progenitor cells in differentiation and/or tissue or organ repair and/or regeneration and/or building are also provided. Methods of using progenitor cells in treatment and prophylaxis of conditions alleviated by administering stem cells or tissue or organ derived from stem cells to a subject or by grafting stem cells or tissue or organ derived from stem cells into a subject or by transplanting stem cells or tissue or organ derived from stem cells into a subject are also provided. Also included are progenitor cells and differentiated cells and/or tissues and/or organs derived therefrom, and kits comprising same.
    Type: Application
    Filed: January 24, 2018
    Publication date: June 21, 2018
    Inventor: Vishal BHASIN
  • Publication number: 20180171291
    Abstract: This invention relates, e.g., to a method for differentiating mammalian (e.g., human) pluripotent stem cells (PSCs) into endothelial cells (ECs) in vitro, by plating a single-cell suspension of PSCs onto a suitable surface such as type IV collagen and culturing the cells with VEGF after which ECs can be harvested. A preferred embodiment of the method first cultures the cells without VEGF and then sequentially cultures the cells with VEGF. Differentiation can be enhanced by adding an inhibitor of transforming growth factor ? to the culturing with VEGF.
    Type: Application
    Filed: February 12, 2018
    Publication date: June 21, 2018
    Inventors: Sharon Gerecht, Sravanti Kusuma