Abstract: A device for securing and monitoring movement of a catheter includes a film having an adhesive disposed on a body-facing surface for securing the film to a body. The device also includes a base mounted on the film, the base comprising a first portion of a guide channel for receiving the catheter. A cover is coupled to the base via a hinge, the cover comprising a second portion of the guide channel, the cover further comprising a rounded portion extending from a distal end of the cover, wherein in the closed configuration, the catheter is completely enclosed by the rounded portion and the first and second portions of the guide channel. The device also includes a positional shift indicator fixedly attached to the catheter and configured to indicate positional shifts by the catheter within the guide channel.

Abstract: This document discusses, among other things, examples of a low profile instrument immobilizer and means for positioning the same. In one example, the low profile instrument immobilizer grasps, secures, and immobilizes an electrode or other instrument that extends through a burr hole in a skull to a target location in a patient's brain.

Abstract: An access sleeve can be attached to a medical device having first and second ends, the first end being positioned inside of a patient and the second end being positioned external to a patient. The access sleeve can include a tubular sleeve body having first and second open ends that define a first lumen extending along a longitudinal axis of the sleeve body. An opening in the sleeve body can connect the first lumen to an outer surface of the sleeve body. The access sleeve can be selectively attached to the medical device (e.g. catheter of a heart pump) and inserted into the access site when the medical device is positioned in the patient. The access sleeve can maintain vascular access to a patient's access site such as an arteriotomy and can be removed without disturbing the position of the medical device.

Abstract: A method for improving function of a cardiac valve in a patient, the cardiac valve having at least one leaflet that is attached to a papillary muscle: Inserting a balloon, that is in a first uninflated condition and having a first diameter, within tissue that is part of to the papillary muscle, and thereby separating tissue that was previously connected together, by a maximum amount equal to the first diameter; inflating the balloon to a second inflated condition having a second diameter greater than the first diameter, thereby permanently stretching tissue in the papillary muscle and separating the tissue from the first diameter to a maximum amount equal to the second diameter; deflating the balloon to the first uninflated condition, and thereby returning the tissue to a separation of a maximum amount substantially equal to the first diameter; and then removing the balloon from the patient.

Abstract: Active Energy Facilitated Drug Delivery platform for delivering therapeutics to biological tissue through electrical conductivity. This delivery method is comprised of an elastic alloy to encase a balloon or drug deposition, where the alloy acts to emit an electric field in aiding and actively allowing the pharmaceutical agent to have enhanced permeation, binding and internalization to cells and the biological matrix. A therapeutic agent is deposited onto a balloon to embody the drug deposition, reservoir whereby the electrical field facilitates the active transfer of a pharmaceutical agent to the target tissue is described.

Abstract: A therapeutic delivery device comprises a layer of biodegradable material wound into a plurality of windings, the plurality of windings comprising an outermost winding defining an internal volume and winding pairs including a first winding pair and a second winding pair. A first therapeutic mass is incorporated in or on the layer the first winding pair and a second therapeutic mass is incorporated in or on the layer along the second winding pair. Perforations extend through at least selected windings.

Abstract: A wound oxygen supply system includes a chassis that defines an oxygen outlet. an oxygen production subsystem is included in the chassis and coupled to the oxygen outlet. A control subsystem is coupled to the oxygen production subsystem and configured to receive humidity information that is indicative of a humidity experienced by the oxygen production subsystem. The control system then uses the humidity information to control power provided to the oxygen production subsystem in order to control an oxygen flow that is created by the oxygen production subsystem and provided through the oxygen outlet to a restricted airflow enclosure adjacent a wound site.

Abstract: An object of the present invention is to provide a microneedle and a method for producing the same that are specialized for individual treatment purposes and can efficiently achieve a treatment effect. The microneedle according to the present invention relates to a microneedle including a drug containing layer, an intermediate layer, and a base layer in order from a tip side, wherein a boundary between the drug containing layer and the intermediate layer has a shape protruding toward the intermediate layer, and a thickness of a central portion of the intermediate layer is smaller than a thickness of a peripheral edge portion. The microneedle according to the present invention can be more easily broken in the intermediate layer than the conventional microneedle, thereby allowing the drug containing layer to be placed to properly target a particular area in epidermis or dermis.

Abstract: The present invention relates to a microstructure including a biocompatible polymer or an adhesive and to a method for manufacturing the same. The present inventors optimized the aspect ratio according to the type of each microstructure, thereby ensuring the optimal tip angle and the diameter range for skin penetration. Especially, the B-type to D-type microstructures of the present invention minimize the penetration resistance due to skin elasticity at the time of skin attachment, thereby increasing the penetration rate of the structures (60% or higher) and the absorption rate of useful ingredients into the skin. In addition, the D-type microstructure of the present invention maximizes the mechanical strength of the structure by applying a triple structure, and thus can easily penetrate the skin. When the plurality of microstructures are arranged in a hexagonal arrangement type, a uniform pressure can be transmitted to the whole microstructures on the skin.

Abstract: The invention pertains to a kit for assembling a disposable applicator for inserting an implant, in particular a rod-like implant containing an active substance, under the skin of a human or animal, the kit comprising a first component, in turn comprising a main housing part providing a handle for grasping and maneuvering the applicator, a cannula, and a cannula holder mounted in the main housing part, the main housing part having an opening which allows introduction of an implant into the proximal end of the cannula or the cannula holder, and, a second component for closing said opening, in turn comprising a second housing part and a rod attached to or forming an integral whole with the second housing part and mountable inside the cannula or the cannula holder.

Abstract: The invention pertains to a kit for assembling a disposable applicator for inserting an implant, in particular a rod-like implant containing an active substance, under the skin of a human or animal, the kit comprising a first component, in turn comprising a main housing part providing a handle for grasping and maneuvering the applicator, a cannula, and a cannula holder mounted in the main housing part, the main housing part having an opening which allows introduction of an implant into the proximal end of the cannula or the cannula holder, and, a second component for closing said opening, in turn comprising a second housing part and a rod attached to or forming an integral whole with the second housing part and mountable inside the cannula or the cannula holder.

Abstract: An adapter (100) has a through hole (103). A first end portion (101) of the adapter includes a tubular portion (110) on which a first projection (111) and a second projection (112) are provided. The adapter can be connected to a male connector at a first position where a claw (32) of the male connector is engaged with the first projection (111) and at a second position where the claw (32) is engaged with the second projection (112). When the adapter is connected at the first position, a flow channel (11) of a male member (10) is sealed with a cover (4). When the adapter is connected at the second position, the adapter compressively deforms an outer circumferential wall (45) of the cover so that the flow channel of the male member is in communication with the through hole (103) of the adapter.

Abstract: A frangible connector has a first side that forms a female luer when a second side is fractured at a predefined break line. The second side may be connected to a fluid circuit, for example, a source of medical treatment fluid such as dialysate.

Abstract: Some embodiments disclosed herein relate to a medical connector with an internal cavity with an internal closure system having a dome valve configured to resist retrograde fluid flow caused by various sources, including patient activity and fluid administration activity. A proximal closure system with a seal member and a moveable plug are also located within the internal cavity.

Abstract: A cap is configured to provide antimicrobial protection to a female luer port of an intravenous device. The cap distributes an antimicrobial solution within the intraluminal surfaces of the port when the cap is connected to the port. A cap may also be designed to distribute an antimicrobial solution around the exterior surfaces of the port. Once connected to a port, the cap can form a seal that minimizes the evaporation of the antimicrobial solution from within the lumen of a port. The cap can therefore provide antimicrobial protection against another device that is connected to the port once the cap is removed.

Abstract: A flow set comprises one-way valves and enables the sequential administration of two fluids from a pair of containers to a patient. The predetermined cracking (threshold) pressure of the one-way valves, namely an inlet pressure at which the first indication of flow occurs,can be individually set at predetermined values to minimize and/or prevent free-flow of the two fluids. A connecting tube segment is part of both the flow path of the first fluid and the flow path of the second fluid, and a pump can be connected to the connecting tubing segment. By reversing the pumping direction of the pump, the two fluids may be sequentially drawn from the pair of containers and thus sequentially administered to a patient.

Abstract: A neuromodulation system for treatment of physiological disorders. The system includes one or more stimulators for stimulating one or more cranial nerves; one or more detectors configured for detecting a predetermined physiological state; and a control unit that controls nerve stimulation by the one or more stimulators so that it is synchronized with the at least one predetermined physiological state detected by the one or more detectors. A method of neuromodulating a patient for treatment of physiological disorder. The method includes the steps of detecting a predetermined physiological state and applying stimulation to one of the cranial nerves during the predetermined physiological state by one or more stimulators of a neuromodulation system.

Abstract: A method of manufacturing a detection/stimulation lead for implantation into a venous, arterial, or lymphatic network is shown and described. The method includes providing a microcable comprising a sheath of insulating material covering an electrically conductive core. The method further includes surrounding a portion of the microcable with an electrically conductive metal ring. The method also includes crimping the ring such that the thickness of the sheath is penetrated by a portion of the metal ring and such that an electrical connection is formed between the metal ring and the electrically conductive core.

Abstract: An implantable leadless cardiac pacing device including a housing having a proximal end and a distal end, an electrode positioned proximate the distal end of the housing configured to be positioned adjacent cardiac tissue, and a tissue anchoring member extending from the distal end of the housing configured to secure the housing to cardiac tissue. The device further includes a tissue engagement verification feature configured to provide feedback upon engagement of the tissue anchoring member in cardiac tissue.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include an implantable medical device. The implantable medical device may include an implantable pacing member having a housing and a lead input. A lead may be coupled to the lead input. The lead may be designed to extend along a pericardial space, epicardium, or both and engage a heart chamber. A passageway may be defined along a portion of the length of the lead.

Abstract: Devices, systems, and methods herein relate to processing biosignal data. These systems and methods may obtain sensor data from a plurality of electrodes and may also be used to augment cortical function, treat neurological disease, and provide insight and analysis of biological processes and/or clinical therapeutic outcomes. An implantable biosignal processing system may comprise a lead having at least one biosignal sensor configured to transmit biosignal data based on electrophysiological activity of a subject. A first processing system may be coupled to the biosignal sensor and comprise a plurality of analog signal processing circuits configured to be selectively powered based on a selectable treatment mode. A second processing system in communication with the first processing system and may comprise a plurality of digital signal processing circuits configured to be selectively powered based on the treatment mode. A neurostimulator may stimulate tissue according to the set of biosignal characteristics.

Abstract: The present disclosure relates to a lead for neuromodulation and/or neurosensing, more in particular for neurostimulation and/or neurorecording, comprising at least one lead cable, at least one electrode section and at least one electrode placed in the electrode section, wherein the lead comprises an anchor, which are pre-attached to the lead (and configured to engage with tissue fixation instrument and/or hold a tissue fixation.

Abstract: A hermetically sealed filtered feedthrough assembly includes an electrically conductive ferrule sealed by a first gold braze to an insulator disposed at least partially within a ferrule opening. A conductive wire is disposed within a via hole disposed through the insulator extending from a body fluid side to a device side. A second gold braze hermetically seals the conductive leadwire to the via hole. A capacitor is disposed on the device side having a capacitor dielectric body with a dielectric constant k that is greater than 0 and less than 1000. The capacitor is the first filter capacitor electrically connected to the conductive leadwire coming from the body fluid side into the device side. An active electrical connection electrically connects the conductive leadwire to the capacitor active metallization. A ground electrical connection electrically connects the capacitor ground metallization to the ferrule and housing of the active implantable medical device.

Abstract: Apparatus (20) for treating an intervertebral disc (30) of a subject is provided. The apparatus (20) includes at least three intra-pulposus exposed electrode surfaces (40), which are configured to be implanted within a nucleus pulposus (42) of the disc (30), at different respective locations; and one or more extra-pulposus exposed electrode surfaces (44), which are configured to be implanted outside the nucleus pulposus (42), in electrical communication with the disc (30). Control circuitry (50) is configured to (a) configure the intra-pulposus exposed electrode surfaces (40) to be cathodes, and the one or more extra-pulposus exposed electrode surfaces (44) to be one or more anodes, and (b) drive the intra-pulposus exposed electrode surfaces (40) and the one or more extra-pulposus exposed electrode surfaces (44) to electroosmotically drive fluid into the nucleus pulposus (40) to increase pressure in the disc (30).

Abstract: A device for treating human keratin materials, in particular with the aid of an electric current. The device includes a reservoir containing an in particular cosmetic or dermatological composition to be applied to the keratin materials, a unit for dispensing the composition contained in the reservoir, in particular a pump, and an end fitting for applying the composition contained in the reservoir, comprising at least one applying member and in particular a plurality of applying members. The applying member is supplied with the composition from the reservoir by the dispensing unit, the composition passing through an intermediate chamber for storing the composition located in the end fitting, the intermediate chamber being at least partially defined by an elastically deformable wall.

Abstract: This disclosure describes methods and systems for preventing, moderating, and/or treating brain injury. The methods herein may include obtaining a test result reflecting a condition of a brain in the subject, determining a stimulation parameter based on the test result, and stimulating a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject. The systems herein may include a processor configured to: receive a test result reflecting a condition of a brain in a subject, and determine a stimulation parameter based on the test result; and a stimulator configured to stimulate a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject.

Abstract: This disclosure describes methods and systems for preventing, moderating, and/or treating brain injury. The methods herein may include obtaining a test result reflecting a condition of a brain in the subject, determining a stimulation parameter based on the test result, and stimulating a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject. The systems herein may include a processor configured to: receive a test result reflecting a condition of a brain in a subject, and determine a stimulation parameter based on the test result; and a stimulator configured to stimulate a nerve based on the stimulation parameter, wherein stimulation of the nerve assists or causes contraction of a respiratory muscle in the subject.

Abstract: Systems and related methods for controlling an ear stimulation device with a personal computing device, in response to determination of electrical contact of an electrode in a stimulator earpiece with an ear of a user of the personal computing device, are described. If the electrode is not in good electrical contact with the ear of the user, delivery of the stimulus is prevented and the user is notified of the status of the electrode. In various aspects, the user is instructed to reposition the earpiece or replace, clean, moisten, or apply gel to at least a portion of the electrode.

Abstract: A peripheral nerve stimulator to stimulate a peripheral nerve to treat essential tremor and other movement disorders, as well as overactive bladder, cardiac dysfunction and neurotransmitter dysfunction is provided. The peripheral nerve stimulator can be a noninvasive surface stimulator to provide multi-modal optimized therapy. Stimulation can be vibrational, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, light, mechanical, chemical, thermal, ultrasonic, radiofrequency (RF), acoustic, infrared, ultraviolet, x-ray, and/or microwave. Stimulation can be delivered using an open loop system and/or a closed loop system with feedback. Stimulation can be to one site or multiple sites.

Abstract: Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising: stimulation means for electrically stimulating at least one nerve with at least one stimulation pulse; control means connected to the stimulation means for controlling at least one characteristic of the at least one stimulation pulse; and modulating means connected to the control means for modulating the at least one characteristic of the at least one stimulation pulse according to the time of day.

Abstract: Disclosed herein are portable and integrated modules and devices for non-intrusive neuromodulation and monitoring of heart function, and methods of operation thereof. The modules and devices include a monitoring unit, an electrical stimulation inducing unit, and three electrodes, such that one of the electrodes is dual-function, being controllably utilized for neuromodulation or for monitoring of heart function.

Abstract: A method for identifying at least one cortical stimulation site in a subject for the application as a target that can be used for treatment of a psychiatric/neurological disorder related to a deep brain region of the ventromedial prefrontal cortex including the subgenual and rostral anterior cingulate by using a first focal-neuromodulation technique, said method comprising: applying pulses of a second a focal-neuromodulation technique to different cortical areas of said subject; simultaneously with the application of said pulses at a cortical area measuring a psychophysiological signal representative of a heart rate of the subject for said cortical area, and when observing a systematic change in psychophysiological signal, identifying a corresponding cortical area as at least one cortical stimulation site that is functionally connected to said deep brain region of the ventromedial prefrontal cortex including the subgenual and rostral anterior cingulate for presenting said target for the treatment.

Abstract: The present invention relates to an electrotherapy stimulation device having at least three fully programmable multipurpose electrodes in fixed positions and the use of such device for achieving various cognitive effects such as those involved in creative problem solving. The electrodes of the present invention are multipurpose electrodes designed so each electrode can selectively serve multiple functions such as, but not limited to, as anode, cathode or ground of a stimulation circuit.

Abstract: An arrangement for reducing intraocular pressure includes a pulse signal source, a probe coupling, and at least one electrode. The probe coupling is configured to be supported on a portion of a living eye. The electrodes are supported on the probe coupling. The electrodes are operably coupled to receive a pulse signal from the pulse signal source.

Abstract: Systems and methods provide notification to a user about pending neurostimulation or ongoing neurostimulation using a variety of notification signals and obtaining a user response to the notification using a variety of methods by which the user response is provided. Systems using implanted neurostimulation devices, external neurostimulators which provide transcutaneous electrical nerve stimulation, or both provide responsive and scheduled therapy regimens that include ecosystem support for augmenting user compliance when treating symptoms, conditions, or disorders. The system is also to assist the user through assessment protocols for improved customization of stimulus regimen attributes such as stimulation protocol parameter values, electrode montages, user surveying, and compliance contingent operations.

Abstract: An implantable stimulator device is disclosed preferably having a lead portion and an electronics module integrated and implantable as a single unit, which can enable trial stimulation to occur in a fully implanted solution for a lengthened or unlimited duration. The side of the housing of the electronic module includes a stylet channel which proceeds through the housing at an angle to the implantable stimulator's long axis and bends to proceed through the lead portion along the long axis. The stylet channel can receive a lead stylet to allow the lead portion and the electronics module to be properly positioned within the patient. Because the proximal end of the lead stylet exits the housing of the electronics module at an angle, it provides a handle to steer the lead portion for proper placement within the spinal column.

Abstract: Techniques for delivery of electrical neurostimulation therapy to a patient are disclosed. In one example, a processor controls delivery of electrical neurostimulation therapy to a patient by an electrical neurostimulation therapy device and via a plurality of combinations of a plurality of electrodes disposed along a lead inserted across an anatomical midline of a spinal cord of the patient and angled relative to the anatomical midline, the lead connected to the electrical neurostimulation therapy device. The processor determines, based on the electrical neurostimulation therapy, a location of a physiological midline of the spinal cord. The processor selects, based on the location of the physiological midline, at least one electrode of the plurality of electrodes for subsequent delivery of electrical neurostimulation therapy to the patient. Further, the processor displays a representation of the physiological midline and the anatomical midline relative to the spinal cord.

Abstract: The present disclosure relates to a system for neuromodulation and/or neurostimulation, for the treatment of a subject. The system comprises a stimulation controller, a stimulation pattern storage means including stimulation data connected to the stimulation controller, an electrical stimulation device and electrical interface between the electrical stimulation device and the subject, the electrical interface being connectable with a bio-interface of the nervous system of the subject. The stimulation data are pre-programmed patterns comprising spatial and temporal components, The stimulation controller sends configuration signals on the basis of the stimulation data to the electrical stimulation device such that via the electrical interface electrical stimulation is provided to the bio-interface, wherein the electrical stimulation provided is characterized by stimulation parameters that vary over time in a pre-programmed manner.

Abstract: A medical apparatus for a patient comprises an implantable system. The implantable system comprises a first implantable device comprising: at least one implantable functional element configured to deliver stimulation energy to tissue of the patient; and an implantable controller configured to provide a stimulation waveform to the at least one implantable functional element, the stimulation waveform comprising one or more stimulation parameters. The apparatus is configured to randomly vary at least one of the one or more stimulation parameters. Methods of providing stimulation energy with randomly varying stimulation parameters are also provided.

Abstract: A device is provide for stimulating neurons. The device includes a stimulation unit that is implantable into a patient's body and that includes multiple stimulation elements for stimulating neurons in a target area of the brain and/or spinal cord of the patient with stimuli. Moreover, the device includes a control unit that actuates the stimulation unit such that multiple groups of stimulation elements generate respective stimuli. In this aspect, each group includes multiple stimulation elements of the stimulation unit with two or more of the groups generating sequences of stimuli in a repetitive manner in a respective time pattern which includes successive cycles. Furthermore, the sequences of stimuli generated by the two or more groups differ in terms of the number of cycles in which the sequence in which the stimulation elements generate the stimuli within one sequence is constant and/or in terms of the duration of respective cycles.

Abstract: Methods and devices for reducing ventricle filling volume are disclosed. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated in a consistent way to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.

Abstract: A method and device is described, which provides electrical stimulation to the brain of a person, where the device comprises an external portion and at least one implantable portion. The external portion provides the energy source for stimulation to the implantable portions. The implantable portions provide at least two conductive paths through the skull and use the skull's high impedance to generate a current loop with the focus of stimulation lying in the current path.

Abstract: An object is to provide a defibrillation catheter that is insertable along a guide wire into a target site in the inside of a cardiac cavity and that can assuredly prevent a short circuit between a first lead wire group and a second lead wire group. The defibrillation catheter of the present invention comprises a multi-lumen tube 10, a first DC electrode group 31G, a second DC electrode group 32G, a first lead wire group 41G made up of lead wires 41 connected to each of constituent electrodes 31 of the first DC electrode group 31G, and a second lead wire group 42G made up of lead wires 42 connected to each of constituent electrodes 32 of the second DC electrode group 32G; and applies voltages between the first DC electrode group 31G and the second DC electrode group 32G. The multi-lumen tube 10 has a center lumen 10L through which the guide wire is insertable, and a sub-lumen 11L and a sub-lumen 12L disposed so as to face each other with the center lumen 10L interposed therebetween.

Abstract: A defibrillator (AED) using an ECG analysis model or algorithm which can function in two different modes. The ECG analysis model is particularly suited for analysis during periods of CPR. Both modes of operation reach a shock decision in essentially the same way, where one or more ECG data segments indicate a shockable cardiac condition. In one mode of operation, the shock decision is irreversible once made. In another mode of operation, the shock decision is reversible if one or more subsequent ECG data segments indicate a no-shock decision. Improved specificity of the model is obtained without undue degradation of sensitivity to shockable ECG.

Abstract: A device for cooling the skin tissue of a patient during a procedure using energy includes a mat-like structure, the mat-like structure having a bottom wall, a top wall and upstanding walls connecting the top wall and the bottom wall, the walls defining an enclosed volume; it also includes one or more electrodes positioned to protrude from the bottom wall and extend through the volume for connection to a source of energy; further, the volume defines a space for holding a cooling substance for cooling the one or more electrodes and the skin tissue during an energy-based procedure.

Abstract: The present invention provides a focused radiotherapy apparatus comprising: at least one source part, provided with a plurality of radioactive sources arranged thereon; at least one collimation part enclosing the source part, and comprising a plurality of collimators aligned corresponding to the radioactive sources, the radiation rays emitted by the plurality of radioactive sources passing through the collimators and then converging to a focal point for treatment.

Abstract: Aspects for treating spinal cord injuries are disclosed. In a particular aspect, a method includes identifying a neurological level of a spinal cord injury, and activating neurons via laser therapy in which a laser beam is applied to an area proximate to the neurological level. In another aspect, a computer-readable storage medium includes computer-readable instructions for performing various acts. Such acts comprise ascertaining a neurological level of a spinal cord injury, and receiving data corresponding to a severity of the spinal cord injury. The acts further comprise outputting a laser calibration according to the neurological level and the severity. A medical device apparatus is also provided, which includes various computer executable components. The computer executable components include an assessment component configured to receive parameters corresponding to a spinal cord injury, and a calibration component configured to ascertain a laser calibration according to the at least one parameter.

Abstract: Methods and apparatuses for phototherapy to treat skin disorders. In particular, described herein are phototherapy dressings for use with phototherapy UV light applicators (sources) to treat skin disorders such as psoriasis. The dressings described herein may include a support body onto which a medicament formed of a hydrogel and coal tar and/or coal tar extract is held. The dressing may be configured so that at least half (50%) of the UV light within a therapeutic range of wavelengths is through the dressing including the medicament to the patient's skin. The dressings may be adapted for use in conjunction with a phototherapy UV light sources.

Abstract: The invention relates to an implantable device for optical stimulation of an organ of the human or animal body, having a probe comprising a tube made of a first transparent material, this tube being hermetically closed by at least one stopper; at least one light source arranged inside the tube; a plurality of electrical connection elements extending through the stopper and electrically connecting said at least one light source to the outside of the tube; and a linking cable arranged outside the tube and connected to said connection elements.

Abstract: Endoscopic delivery of Red/NIR light to the Substantia Nigra to treat Parkinson's Disease in order to raise the energy levels in the substantia nigra.