Abstract: Design and use of an administered drug in the form of a nanoparticle or molecule is described. In certain examples, the nanoparticle has a core and a shell surrounding the core. The core may be configured or designed to provide useful X-ray attenuating properties, gamma ray emission properties, magnetic properties, or therapeutic effects. In certain aspects, the nanoparticle or molecule is sized so as to either distribute from or remain in the blood pool, while still being eliminated by the kidneys.

Abstract: Design and use of an administered drug in the form of a nanoparticle or molecule is described. In certain examples, the nanoparticle has a core and a shell surrounding the core. The core may be configured or designed to provide useful X-ray attenuating properties, gamma ray emission properties, magnetic properties, or therapeutic effects. In certain aspects, the nanoparticle or molecule is sized so as to either distribute from or remain in the blood pool, while still being eliminated by the kidneys.

Abstract: Provided herein are examples of metal chelating ligands that have high affinity for manganese. The resultant metal complexes can be used as MRI contrast agents, and can be functionalized with moieties that bind to or cause relaxivity change in the presence of biochemical targets.

Abstract: The present invention encompasses compositions comprising two spectrally distinct radionuclides separated by a site susceptible to cleavage. Compositions of the invention may be used to detect enzyme activity and/or image diseases associated with said enzyme activity.

Abstract: The invention provides a method for the purification of 227 Th from a mixture comprising 227 Th and 223 Ra, said method comprising: i) preparing a first solution comprising a mixture of 227 Th and 223 Ra ions dissolved in a first aqueous buffer; ii) loading said first solution onto a separation material such as a strong cation exchange resin; iii) eluting 227 Th from the separation material, whereby to generate a second solution comprising 227 Th; iv) Optionally rinsing said separation material using a first aqueous washing medium; The invention additionally provides a method for forming a radio pharmaceutical comprising complexing the purified 227 Th, the pharmaceutical product and its use in treatment of disease such as cancer and a kit for generation of such a product.

Abstract: A fluid delivery system illustratively includes a spout, at least one valve in fluid communication with the spout, and a disinfectant device, illustratively an antibacterial device, fluidly coupled to the spout. The faucet is configured to selectively flow water through the disinfectant device in response to a user input to the faucet. In another illustrative embodiment, the fluid delivery system includes an outer housing, a plurality of fluid devices supported by the outer housing, and an ozone generator fluidly coupled to the fluid devices.

Abstract: UV hard-surface disinfection system that is able to disinfect the hard surfaces in a room, while minimizing missed areas due to shadows by providing multiple UV light towers that can be placed in several areas of a room such that shadowed areas are eliminated and that can be transported by a cart that is low to the ground such that the towers may be loaded and unloaded easily by a single operator. The system is able to be controlled remotely, such that during activation of the system, no operator is present, and to automatically cut power to all towers in the event that a person enters the room.

Abstract: A sterilization method may include loading a vacuum wrapper containing and sealing a target object in a vacuum container, evacuating the vacuum container and the vacuum wrapper, injecting a sterilant into the vacuum wrapper, which is disposed in the vacuum container and is maintained at a vacuum state, and venting the vacuum container to allow it to have an atmospheric pressure.

Abstract: An apparatus for sanitizing hands comprising a base, wherein the base is configured to dispense towels; at least one dispensing chamber configured to store a viscous material comprising a conduit; at least one sensor activated pump mechanism comprising a sensor device connected to a circuit system, an actuator, and an energy source; and wherein when the sensor device is triggered, the sensor activated pump mechanism is configured to draw a predetermined volume of viscous material through the conduit and out the discharge nozzle.

Abstract: The invention provides to a powdered composition of additives and a method of use thereof for increasing the visibility, potency and coverage of disinfectant solutions, such as bleach.

Abstract: A process for the preparation of a sterilized ceramic body including or essentially consisting of stabilized zirconia of a defined colour, including the steps of: providing a ceramic primary body including or essentially consisting of stabilized zirconia of a first colour A, and sterilizing the primary body using radiation sterilization whereby the primary body undergoes a colour change to a colour B. The process includes the further step of irradiating the sterilized primary body with electromagnetic radiation of at least one wavelength lying in the wavelength band ranging from 150 nm to 700 nm to induce an at least partial reversal of the colour change to obtain a colour C of the sterilized ceramic body, the colour C complying with the following requirements in the CIELAB colour space: L* being from 54 to 95, a* being from ?15 to 15 and b* being from ?15 to 15.

Abstract: A freshening composition is provided. The composition includes at least one particle, and an aqueous carrier. The composition includes a polysaccharide system having a first polysaccharide and a second polysaccharide. The first polysaccharide is xanthan gum and the second polysaccharide is selected from the group consisting of konjac gum, locust bean gum, and combinations thereof. The composition may include an unencapsulated perfume.

Abstract: A freshening composition is provided. The freshening composition includes a plurality of particles, a structurant system, and an aqueous carrier. The composition has a spray shear viscosity, as measured according to the SPRAY SHEAR VISCOSITY TEST METHOD described herein, of less than about 0.025 Pa·s. The composition has a creep recovery ratio of at least about 0.1, as measured according to the CREEP RECOVERY RATIO TEST METHOD described herein, or a yield stress of greater than 0 Pa and less than 1.0 Pa, as measured by the YIELD STRESS TEST METHOD described herein.

Abstract: To provide a porous silica which is capable of effectively eliminating odors of methyl mercaptan, hydrogen sulfide, nonenal and the like, said odors being difficult to be eliminated by a silica porous material that contains no metal. A porous silica containing particles that are provided with primary pores, wherein the particles contain a metal containing substance complex having a particle size of 1-100 nm. This porous silica has a specific surface area of 500 m2/g or more.

Abstract: An air purification unit has a housing which has at least one inlet opening for delivering an air stream and at least one outlet opening for discharging the air stream delivered via the inlet opening. At least one air purification unit and at least one lighting unit are arranged in the housing, wherein the at least one air purification unit and the at least one lighting unit are arranged opposite one another in the housing. The at least one air purification unit has at least one photocatalytically active surface region. The air stream is guided in the housing at least partially along the at least one photocatalytically active surface region of the at least one air purification unit, wherein the surface region is at least partially coated with titanium dioxide or doped with titanium dioxide ions ions.

Abstract: The invention relates to a bandage comprising a flat web material as a substrate, wherein a self-adhesive cohesive adhesive compound is at least partially applied to both flat sides of the substrate, and the substrate is impregnated with a liquid preparation, characterised in that said adhesive compound comprises an anhydrous cohesive pressure sensitive adhesive which contains natural and/or synthetic rubber, this natural and/or synthetic rubber being dissolved in an organic solvent for application, or the pressure sensitive adhesive being molten for application.

Abstract: Method of applying a skin beneficial agent to an absorbent article including a topsheet layer having a body facing surface and a garment facing surface, the article having a longitudinal front portion, a longitudinal back portion and a crotch portion located between the front and the back portion. The method includes at least the step of printing, by means of an in-line synchronized print technique, a water based ink composition including a binder and a microencapsulated skin beneficial agent on the article, the skin beneficial agent being at least a partly hydrophobic or lipophilic substance or additive, and the microcapsule material being water-insoluble at 20° C.

Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.

Abstract: The present invention relates to a silicone foam that is produced in-situ at a wound site, e.g. in a wound cavity, through a multi-component system, based on a physical foaming process, wherein the gas required to form the foam structure is provided through the blowing agent independently of the curing reaction of the polyorganosiloxane components of the multi-component system. Therefore, in accordance with the present invention, the blowing agent is provided as a distinct entity of the multi-component system that is, in particular, not the result of any chemical reaction taking place in the multi-component system. The present invention also relates to a device for producing the foam and the corresponding negative pressure wound therapy kit.

Abstract: Certain configurations of adhesive materials are described which comprise a crosslinked derivatized atelocollagen. In some configurations, the crosslinked, derivatized atelocollagen is cured to provide a burst strength of at least 55 kPa or 60 kPa (or more) as tested by ASTM F2392-04. In some instances, the crosslinked derivatized atelocollagen comprises a methylated atelocollagen that is crosslinked using one or more functionalized crosslinking agents.

Abstract: Methods of treating a complex wound by administering to a complex wound in the individual a therapeutically effective amount of a fetal support tissue product to treat the complex wound. Methods of treating a complex lower extremity ulcer by administering to a complex lower extremity ulcer in the individual a therapeutically effective amount of a fetal support tissue product to treat the complex lower extremity ulcer. Methods of reducing or preventing scar formation from granulation tissue by administering a fetal support tissue product to granulation tissue. Methods of repairing a spina bifida defect by administering to the defect in the individual a therapeutically effective amount of an umbilical cord product.

Abstract: The invention provides methodologies and apparatus for producing acellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and nonimmunogenic. The inventive method allows for the production of multiple decellularized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes. In clinical use, the decellularized grafts produced exhibit significantly improved in long-term durability and function.

Abstract: Methods of preparing calcification-resistant bioprosthetic tissue include providing fresh biological tissue, cross-linking the tissue, treating the cross-linked tissue with an alcohol for a time sufficient to allow the alcohol to be diffused into the tissue, and treating the alcohol-treated fixed tissue with a polyol for a time sufficient to allow fluid in the tissue to be replaced by the polyol. The methods may include sterilizing the cross-linked tissue in a solution including propylene oxide or peracetic acid either before or after the alcohol treatment step; or drying the alcohol/polyol-treated, cross-linked tissue, sterilizing the dried tissue by exposure to ethylene oxide or peracetic acid, and storing the sterilized tissue in a dry, ambient environment. The treated tissue may be a tissue component for a bioprosthetic valve, a valve assembly for a bioprosthetic valve or a fully assembled bioprosthetic valve incorporating the tissue.

Abstract: This disclosure relates compositions comprising upconverting core-shell nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable intraocular lenses.

Abstract: In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects.

Abstract: A fluid flow circuit assembly for a biological fluid processing device, comprising a PVC tubing comprising a polymeric plasticizer and/or a high molecular weight plasticizer having a molecular weight of 540 g/mol or more. The fluid flow circuit assembly also comprises a medical device component comprising a bond surface to which the PVC tubing is bonded by a solvent, wherein the bond surface comprises a polyester elastomer, plasticized PVC, and/or a polycarbonate.

Abstract: A Quaternary Mg—Zn—Ca-based alloy and a heat treatment process for producing bioresorbable bone fixation implants are described thereof. The mechanical and biocorrosion properties of the fabricated Mg-based alloy were improved by combining careful selection of the alloy's chemical composition and subsequent post-shaping process (heat treatments). Heat treatment process is more privileged especially after fabricating the part into its final shape such as in additive manufacturing (3D-printing) and powder metallurgy. In this way, it is possible to produce biocompatible, strong and less corrosive patient-specific bone fixation hardware. Also, such heat-treated Mg—Zn—Ca-based parts can be further coated with various types of biocompatible ceramic coatings for slower and more tailored biocorrosion rates.

Abstract: This document provides devices, system, and methods for treating an abscess cavity. For example, procedures that involve supplementing a biocompatible filler material with a therapeutic agent to promote tissue regeneration and healing are provided. The biocompatible filler materials that are treated with a therapeutic agent are implanted into the abscess cavity. The biocompatible filler material provides a tissue growth scaffold, and the therapeutic agent enhances tissue growth and healing.

Abstract: A waste collection unit is provided that comprises a vacuum pump and smoke evacuation system including a blower and blower motor. The vacuum pump, the blower, and the blower motor, create noise. This noise is attenuated in first and second sound attenuating enclosures for the vacuum pump and the blower and blower motor. A cleaning system is also provided 100 with rotating liquid delivery devices. An actuator is operatively coupled to the liquid delivery devices to rotate the liquid delivery devices.

Abstract: A portable negative pressure wound therapy system includes a dressing assembly for positioning over a wound to apply a negative pressure to the wound and a canister assembly. The canister assembly includes a control unit having a vacuum source and a controller and a collection canister in communication with the dressing assembly operable to receive fluid from the wound. The collection canister has a filter assembly having a filter and a passageway between the filter and a wall of the collection canister. The collection canister also includes a canister interface having a suction port, an inlet port, and a channel. The vacuum source draws air through the suction port from the channel which draws air from the passageway connected to the channel, the air in the passageway is drawn from the collection canister through the filter, and the air in the collection canister is drawn through the inlet port.

Abstract: A single step body insertion device comprises a cannula and a Veress needle which penetrates the skin surface and relevant tissue layers to reach fluid and/or gases that need to be removed from the body. The cannula shaft and tapered tip are of a polymeric material which is flexible and kink resistant. The Veress needle has an engagement feature for engagement with the tapered tip of the cannula for delivery of the cannula into the body as the Veress needle is inserted into the body. The device is used for the management of conditions such as pneumothoraxes and pleural effusions as well as other conditions that require release of fluid and/or gas from the body.

Abstract: Disclosed herein are systems and methods for providing reduced or negative pressure, and more particularly cyclical reduced pressure, to treat a wound. The system can include a wound dressing, a fluid collection container, a suction source, filters, and conduits. In addition, the system can include a control device and sensors. The sensors may be configured to monitor certain physiological conditions of a patient such as temperature, pressure, blood flow, blood oxygen saturation, pulse, cardiac cycle, and the like. Application of cyclical reduced pressure between two or more values below atmospheric pressure may be synchronized with the physiological conditions monitored by the sensors. Certain embodiments of the system utilize an air reservoir and one or more valves and pressure sensors or gauges to allow for rapid cycling of the level of reduced pressure within the wound dressing between two or more reduced pressure values.

Abstract: An apparatus is provided for lip conditioning, including a mouthpiece having an opening configured to press against a portion of tissue or lips of a user; and a chamber configured to receive the portion of the tissue or lips of the user through the opening, wherein when the apparatus is configured to generate suction within the chamber, and to apply a negative pressure to a portion of tissue or lips of a user.

Abstract: An implantable blood pump includes an impeller rotatable about a rotational axis, having a body with a bottom surface at a downstream end and a central opening centered about the axis extending at least partially through the body from the bottom surface. A projecting element, e.g., a shaft, extends from below the bottom surface into or through the opening to support the impeller. The body can be configured to drive a primary downstream blood flow along an exterior of the body to beyond a peripheral edge of the bottom surface, and to provide a secondary downstream blood flow through the opening and along the bottom surface to beyond the peripheral edge, the secondary flow improving washing of a bearing surface.

Abstract: Materials and methods related to blood pump systems are described. These can be used in patients to, for example, monitor arterial pressure, measure blood flow, maintain left ventricular pressure within a particular range, avoid left ventricular collapse, prevent fusion of the aortic valve in a subject having a blood pump, and provide a means to wean a patient from a blood pump.

Abstract: A flow rate of blood through an implantable blood pump is determined based on a parameter related to the flow, such as a parameter related to thrust on the rotor of the pump. An amount of current supplied to the pump is used to determine each of a first flow rate value and second flow rate values. Each of the first and second flow rate values, in combination with the parameter related to thrust on the rotor of the pump, are used to calculate a flow rate of blood through the pump.

Abstract: A heart failure recovery device includes a fluid pump having an inlet and an outlet in fluid communication with a pump reservoir, and a pumping element disposed within the pump reservoir, the pumping element including a protrusion that in an active state is configured to rotate and move fluid away from the inlet and towards the outlet. A receiver coil can be electrically coupled to the fluid pump and is configured to subcutaneously absorb electromagnetic energy for powering the fluid pump. In certain embodiments, an implantable port provides fluid access to the pump reservoir for cleaning and maintaining the fluid pump. In other embodiments, a valve closes fluid access to at least one of the inlet and the outlet during periods when the device is not being used for treatment.

Abstract: A circulatory assist system is disclosed, the system including an implantable electrical device having an electric motor, an implantable controller connected to the implantable electrical device, and an implantable power source connected to the controller for supplying power to the controller. The controller is attachable to a first side of a percutaneous connector. A second side of the percutaneous connector, opposite to the first side, allows external connectivity to said controller.

Abstract: The application refers to a medical treatment device a medical treatment system and a method for operating the medical treatment device and medical treatment system for treatment of a patient, comprising a sensor interface for receiving sensor data from a plurality of different external and internal peripheral sensors, a controller for processing the received sensor data in order to calculate control data and for providing the calculated control data for controlling medical treatment-related devices or for controlling a configuration of medical treatment-related apparatuses and an output interface for providing the control data.

Abstract: In an embodiment, a dialysis machine includes a dialyser, a fluid line in fluid communication with the dialyser, an inlet valve enabling fluid to flow into the fluid line towards the dialyser during a dialysis treatment, a disinfectant line connected to the fluid line via a disinfectant valve upstream of the dialyser, the disinfectant valve enabling a disinfectant fluid to be provided to at least part of the fluid line during a disinfection procedure, and a controller programmed to open the inlet valve, while the disinfectant line is connected to a source of disinfectant fluid, to create a positive pressure gradient across the disinfectant valve as fluid flows into the fluid line towards the dialyser, the positive pressure gradient ensuring that the disinfectant fluid from the source of disinfectant fluid does not leak into the fluid line during the dialysis treatment.

Abstract: A device for extracorporeal blood treatment, in particular a dialysis device, including an internal fluidic system for a treatment liquid, in particular for a dialysis liquid, the internal fluidic system having at least two liquid connectors for connecting a substantially cylindrical filter element, in particular a dialyzer, to the internal fluidic system for passing a treatment liquid through the filter element, and including a mounting for exchangeably holding the filter element in such a way that the filter element can be connected to the liquid connectors of the internal fluidic system and to an extracorporeal blood line in an intended manner, wherein the mounting for holding the filter element is designed in such a way that a cylinder longitudinal axis of the filter element is substantially horizontally aligned.

Abstract: The disclosure relates to a dialysis system comprising a dialysate side and a blood side. In particular, and for example, in some embodiments, a dialysis system is provided and comprises a dialyzer including and a blood filter configured to divide the dialyzer and dialysis system into a blood side and a dialysate side. The blood side includes a blood circuit comprising a blood pump, a blood removal line, a blood return line, and a blood return line valve (BRV). The blood removal line and blood return line converge to a single venous access line in blood communication with a patient. The dialysate side includes a dialysate fluid circuit comprising first and second pump chambers each having a plurality of respective valves configurable to enable or prevent fluid communication with both the dialyser side of the dialyser and a drain. Each of the first and second pump chambers are configurable, based on the configurations of the valves, to comprise a blood accumulation chamber.

Abstract: The present invention relates to a method for checking a dialyzer for the presence of a leak in the semipermeable membrane of the dialyzer, wherein the membrane divides the inner dialyzer space into a least one blood chamber and into at least one dialyzate chamber, wherein the blood chamber is flowed through by blood in the operation of the dialyzer and is in fluid communication with a blood-side line system and the vascular system of the patient, and wherein the dialyzate chamber is flowed through by dialysis fluid in the operation of the dialyzer and is in fluid communication with a dialyzate-side line system, wherein the method comprises the following steps: a) emptying the blood chamber or the dialyzate chamber of blood and of dialysis fluid respectively and keeping the fluid (blood or dialyzate) in the non-emptied dialyzate chamber or blood chamber; b) building up a test pressure by means of a gas, in particular by means of air, in the emptied blood chamber or in the emptied dialyzate chamber; and

Abstract: A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

Abstract: An extracorporeal blood circulation system monitors blood level in a reservoir which temporarily stores the blood. A memory storage unit stores blood pressure measurements from a pressure sensor monitoring a blood pressure within a tube unit conveying blood from the reservoir relative to atmosphere. A processing unit that detects a height of a top surface of the blood stored in the reservoir based on changes in the blood pressure measurements and a conservation of mechanical energy of a blood flow inside the tube unit. A notification is generated if an abnormality is detected in the height of the blood in the reservoir.

Abstract: The present specification discloses a portable dialysis system comprising a mechanism that allows the user to accurately position an air bubble in a venous line, so that it can be safely removed. When an air bubble is detected, the system automatically runs the blood pump in a direction such that the air bubble is placed close to the extraction point on the venous line, from where it can safely be removed using a needleless syringe.

Abstract: A flow control system of a clinical perfusion system comprises flow control devices 110, such as pumps, valves and/or clamps, capable of controlling a fluid flow rate according to flow rate parameters from the flow control system. The flow control system comprises an indicator arrangement including a device indicator 122a, 122b on each flow control device 110 capable of providing a plurality of indications. The device indicators 122a, 122b are controllable by the flow control system to indicate an active condition of the flow control device 110 independently of the flow rate parameters. This allows the indication provided by the device indicator 122a, 122b to be adjusted for different clinical environments, and to provide colour indications that match the colour range discernible by users affected by colour vision deficiency.

Abstract: A system for removing undesirable elements from blood. The system includes a centrifuge bowl to separate the blood into components according to relative densities of the components, a pump to provide wash solution that washes the blood in the centrifuge bowl, and a controller to wash the blood in the centrifuge bowl in a first wash and remove first undesirable elements and to wash the blood in the centrifuge bowl in a second wash and remove trapped undesirable elements. The controller to further mix the blood and the wash solution in the centrifuge bowl and provide diluted blood, separate the diluted blood into concentrated blood and the wash solution, fill the centrifuge bowl with previously concentrated blood to build a buffy coat, and empty the centrifuge bowl of the concentrated blood and the previously concentrated blood after the buffy coat is reached.

Abstract: A container for closing caps for syringes has a plurality of seats, each of which is suited to be engaged, in a sliding manner, by a respective closing cap, and has a movable portion configured to move between a locking position of the relevant closing cap in the seat and a release position.

Abstract: A medical instrument housing container includes a container body including a substantially rectangular base, a peripheral wall having a lower end that is contiguous to a perimeter of the base and that extends upward, and a peripheral edge member that comprises a plurality of peripheral edges, that is contiguous to an upper end of the peripheral wall, and that extends outwardly, wherein the substantially rectangular base, the peripheral wall, and the peripheral edge member are molded from resin, and the container body has an opening surrounded by the peripheral edge member; a plurality of medical instruments held in the container body; and a protection film that is adhered or heat-sealed to the peripheral edge member for covering and sealing the opening. At least a portion of the peripheral edge member is curved inwardly.