Patents Issued in April 18, 2019
  • PROCESS FOR PRODUCING A FUEL FROM LIGNOCELLULOSIC FEEDSTOCK
    Publication number: 20190112238
    Abstract: The present invention relates to a method for producing a composition for use in land application. The method comprises: (a) obtaining a fermentation product by a production process comprising the steps of: (i) treating lignocellulosic feedstock to produce sugar; (ii) fermenting the sugar to produce a fermented mixture comprising the fermentation product; and (iii) recovering the fermentation product from the fermented mixture in one or more stages to produce a concentrated fermentation product and still bottoms; and (b) recovering the still bottoms, the still bottoms comprising organic and inorganic components; and (c) providing the still bottoms for use in a land application. Also provided is a soil conditioning composition for use in land application. The soil conditioning composition contains still bottoms and optionally other components.
    Type: Application
    Filed: December 21, 2018
    Publication date: April 18, 2019
    Inventors: Patrick J. Foody, Robert Glenns
  • MICRONUTRIENT COMPOSITIONS
    Publication number: 20190112239
    Abstract: An agrochemical micronutrient concentrate and or formulations with dispersants for said concentrates/formulations, in particular a dispersant for use in suspending solid micronutrients in suspension concentrate type formulations comprising one or more micronutrients. The dispersant is preferably a water dispersible styrene (meth)acrylic copolymer. The micronutrient is selected from zinc oxide, manganese carbonate, manganese oxide, or calcium carbonate, and present in the concentrate at 40 wt. %. or more. The present invention also includes methods of treating crops with such micronutrient formulations.
    Type: Application
    Filed: December 7, 2018
    Publication date: April 18, 2019
    Applicant: Croda International Plc
    Inventor: Márcia Fernanda Hergert Pereira Werner
  • REACTION PRODUCTS AND METHODS FOR MAKING AND USING THE SAME
    Publication number: 20190112240
    Abstract: Reaction products and methods for making and using the same are provided. The reaction products particularly may include adducts of two or more reactants. The adducts particularly can incorporate a nitrification inhibitor, such as DCD. In particular embodiments, reaction products may be formed from the reaction of formaldehyde, DCD, urea, and an ammonia source. The adducts may be included in agricultural products, including fertilizer compositions and nitrification inhibitor systems. Fertilizer compositions including the adducts can be beneficial for reducing leaching of nitrification inhibitors applied to soil.
    Type: Application
    Filed: November 12, 2018
    Publication date: April 18, 2019
    Applicant: KOCH AGRONOMIC SERVICES, LLC
    Inventors: KURT D. GABRIELSON, MARY L. EPLING
  • USE OF A CATION SOURCE TO PREVENT DECOMPOSITION OF (THIO)PHOSPHORIC ACID TRIAMIDE UREASE INHIBITORS WHEN A PHOSPHORUS-CONTAINING FERTILIZER IS PRESENT
    Publication number: 20190112241
    Abstract: A cation source to prevent decomposition of a (thio)phosphoric acid triamide is disclosed. A method for preventing decomposition of a (thio)phosphoric acid triamide by adding a cation source is disclosed. A mixture comprising a cation source and a (thio)phosphoric acid triamide is disclosed. A granule coated with a cation source and comprising a fertilizer is disclosed. A composition obtainable by specific processes and comprising a (thio)phosphoric acid triamide, a fertilizer mixture, and a cation source is disclosed.
    Type: Application
    Filed: March 23, 2017
    Publication date: April 18, 2019
    Inventors: Maarten Staal, Johannes G Reuvers, Wolfram Zerulla, Markus Schmid, Uwe Thiel
  • USE OF TYPE OF COMPOUNDS AS ENERGY-CONTAINING MATERIAL
    Publication number: 20190112242
    Abstract: The present application belongs to the field of energetic compounds, and particularly relates to the use of a perovskite-type compound ABX3 as an energetic material. As a finding of the present application, the structural characteristics of the perovskite type enables the type of compound to be highly stable, thus overcoming the unsafety of an explosive having poor stability in the prior art. Meanwhile, the structural characteristics of the compound, such as rich energetic ligands, as well as the alternately arranged oxidizing energetic anions and reducing organic cations in the space, endow the compound with excellent performance on instantaneously releasing energy at detonation. The resulting three-dimensional structure allows the compound to not only have an energetic material effect but also overcome shortcomings of some existing energetic materials.
    Type: Application
    Filed: August 11, 2017
    Publication date: April 18, 2019
    Applicant: YICHANG ENERGY MATERIALS TECHNOLOGY CORPORATION LIMITED
    Inventors: Weixiong ZHANG, Shaoli CHEN, Xiaoming CHEN
  • METHOD FOR FLUORINATING PERCHLORINATED COMPOUNDS
    Publication number: 20190112243
    Abstract: The present invention relates to a method for preparing a polyinsaturated perfluorinated compound B from a polyinsaturated perhalogenated compound D having the formula CnX2(n?m+1), in which X is independently selected from one of the halogens, F, Cl, Br or I, provided at least one X is not fluorine; n is the number of carbon atoms and is at least higher than or equal to 4, m is the number of double carbon-carbon bonds and is higher than or equal to 2, wherein the method comprises a step in which compound D is fluorinated in the presence of a fluorinating agent of general formula AFp, in which A is hydrogen, an alkali metal or an alkaline earth metal, and p is 1 or 2, and in the presence of an aprotic organic polar solvent; the method being carried out with a molar ratio of AFp to compound D of less than 1.45*2(n?m+1).
    Type: Application
    Filed: March 20, 2017
    Publication date: April 18, 2019
    Applicant: Arkema France
    Inventors: Grégory Schmidt, Rémy Teissier
  • METHOD FOR PREPARING HEXAFLUOROBUTADIENE
    Publication number: 20190112244
    Abstract: The present invention relates to a method for preparing hexafluorobutadiene comprising the following steps: (a) hydrodechlorinating hexachlorobutadiene to form a first stream comprising 1,2,3,4-tetrachlorobutadiene and optionally unreacted hexachlorobutadiene; (b) fluorinating the first stream comprising 1,2,3,4-tetrachlorobutadiene obtained in step (a) to form a second stream comprising 1,1,2,3,4,4-hexafluorobutane, (c) dehydrogenating the second stream comprising 1,1,2,3,4,4-hexafluorobutane to form a third stream comprising hexafluorobutadiene.
    Type: Application
    Filed: March 20, 2017
    Publication date: April 18, 2019
    Applicant: Arkema France
    Inventors: Grégory Schmidt, Rémy Teissier
  • METHOD FOR HYDROGENATING CARBOXYLIC ACIDS IN ORDER TO FORM ALCOHOLS
    Publication number: 20190112245
    Abstract: Process for the continuous hydrogenation of a carboxylic acid (I) to an alcohol (II) by means of hydrogen at a temperature of from 100 to 300° C. and a pressure of 10 to 33 MPa abs in a reactor tube through which axial flow occurs and which has a fixed-bed catalyst which is fixed therein and comprises at least one element from the group consisting of Re, Co and Cu, and in which the carboxylic acid (I) to be hydrogenated is present in a liquid mixture (Ill) comprising the carboxylic acid (I), water and alcohol (II), where the mixture (Ill) has an acid number of from 0.2 to 25 mg KOH/g and comprises at least 15% by weight of water and at least 20% by weight of alcohol (II) and the flow velocity of the flowing liquid calculated on the basis of the geometric cross-sectional area of the empty, catalyst-free reactor tube is from 10 to 50 m/h.
    Type: Application
    Filed: March 29, 2017
    Publication date: April 18, 2019
    Inventors: Rolf PINKOS, Stefan RITTINGER, Christoph NUEBLING, Olivier ABILLARD
  • INTEGRATED TECHNIQUES FOR PRODUCING BIO-METHANOL
    Publication number: 20190112246
    Abstract: Methods and systems for producing bio-methanol can include anaerobic digestion of a biomass feedstock to produce biogas including methane and carbon dioxide, partial oxidation of the biogas with oxygen from water electrolysis to produce syngas, synthesizing bio-methanol from the syngas and hydrogen from the water electrolysis, storing the bio-methanol during off-peak electricity demand, intermittently generating electricity from the bio-methanol during peak electricity demand and using such electricity for the water electrolysis. The techniques provide a route for the production of bio-methanol without the engagement of fossil fuels as feedstocks and mitigating fossil fuel derived greenhouse gas emissions from processing and utilization of transportation fuels and commercial or industrial alcohols.
    Type: Application
    Filed: February 15, 2017
    Publication date: April 18, 2019
    Inventor: Norman J. MacGregor
  • PROCESS OF SEPARATING COMPONENTS OF A FERMENTATION BROTH
    Publication number: 20190112247
    Abstract: A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in a fermentor for a sufficient period of time to produce 1,4-BDO. The 1,4-BDO-producing microorganism includes a microorganism having a 1,4-BDO pathway having one or more exogenous genes encoding a 1,4-BDO pathway enzyme and/or one or more gene disruptions. The process for producing 1,4-BDO further includes isolating 1,4-BDO.
    Type: Application
    Filed: May 9, 2018
    Publication date: April 18, 2019
    Inventors: Warren Clark, Michael Japs, Mark J. Burk
  • Method for Increasing UV Transmittance of Ethylene Glycol
    Publication number: 20190112248
    Abstract: The present invention provides a method for increasing the UV transmittance of ethylene glycol. The method uses an ethylene glycol solution and hydrogen as raw materials, and uses an alloy catalyst comprising nickel, one or more rare-earth elements, tin, and aluminum, the contents thereof in parts by weight being 10-90, 1-5, 1-60, and 5-9, respectively. The method of the present invention uses an inexpensive, stable-in-aqueous-phase, carrier-free alloy as a catalyst, and continuously adds hydrogen to reduce unsaturated impurities in ethylene glycol. In application of the method of the present invention in continuous industrial-scale production, the use of this type of alloy catalyst could be especially significant for the achievement of long-term system stability and control of production costs.
    Type: Application
    Filed: March 30, 2017
    Publication date: April 18, 2019
    Inventors: Yi Yuan, Haiyu Ren
  • MULTITUBULAR REACTOR FOR LIQUID PHASE ALCOHOL DEHYDROGENATION AND METHOD FOR LIQUID PHASE ALCOHOL DEHYDROGENATION
    Publication number: 20190112249
    Abstract: The invention relates to a multitubular reactor for dehydrogenation of liquid phase alcohol dehydrogenation and a method of liquid phase alcohol dehydrogenation. Most of the alcohol dehydrogenation reaction is endothermic reaction, the reaction temperature is high and the equilibrium conversion rate is low.
    Type: Application
    Filed: June 13, 2017
    Publication date: April 18, 2019
    Applicant: FuZhou University
    Inventors: Huidong Zheng, Suying Zhao, Jingjing Chen, Naixin Wu, Dan Wu
  • PROCESS FOR THE PREPARATION OF LIGHTLY-BRANCHED HYDROPHOBES AND THE CORRESPONDING SURFACTANTS AND APPLICATIONS THEREOF
    Publication number: 20190112250
    Abstract: Processes to prepare lightly branched surfactant products comprise combining at least one olefin and a coordination-insertion catalyst under conditions such that at least one oligomer product is formed. The surfactant products comprise a main carbon chain containing an average of between 0.5 and 2.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 18, 2019
    Applicant: Dow Global Technologies LLC
    Inventors: Paul R. Elowe, Wanglin Yu, Brad C. Bailey, Michael L. Tulchinsky, Andre B. Argenton, Daniel J. Arriola, Jerzy J. Klosin
  • PROCESS FOR PREPARING AN UNSATURATED CARBOXYLIC ACID SALT
    Publication number: 20190112251
    Abstract: The present invention relates to a catalytic process for preparing an ?,?-ethylenically unsaturated carboxylic acid salt, comprising contacting an alkene and carbon dioxide with a carboxylation catalyst being a transition metal complex, an alkoxide, and an organic solvent, to obtain an ?,?-ethylenically unsaturated carboxylic acid salt, the organic solvent being incompletely miscible with water at a pressure of 1 bar at at least one temperature T and selected from amides and ureas, T being a temperature in the range from 10° C. to 90° C.
    Type: Application
    Filed: April 4, 2017
    Publication date: April 18, 2019
    Applicant: BASF SE
    Inventors: Thomas SCHAUB, Rocco PACIELLO, Nuria HUGUET SUBIELA, Oliver TRAPP, Simone MANZINI
  • METHODS FOR USING MACROPOROUS INERT MATERIALS IN MONOMER PRODUCTION
    Publication number: 20190112252
    Abstract: The present invention provides methods for monomer production, for example, acrylic acid, wherein the methods comprise oxidizing one or more reactant gases, for example, propylene, in a fixed bed reactor, preferably, two fixed bed reactors, in the presence of oxygen and a mixed metal oxide catalyst to form an oxidized gaseous mixture and, at any point in the oxidizing, feeding or flowing the one or more reactant gases or the oxidized gaseous mixture through an inert macroporous material that has a pore volume of from 0.2 cm3/g to 2.0 cm3/g, a surface area of from 0.01 to 0.6 m2/g, and wherein from 30 to 98 wt. % of the total pore volume in the inert macroporous material has a pore diameter of at least 100 ?m.
    Type: Application
    Filed: April 17, 2017
    Publication date: April 18, 2019
    Applicant: Rohm and Haas Company
    Inventor: Jinsuo Xu
  • Catalytic Performance in Processes for Preparing Acetic Acid
    Publication number: 20190112253
    Abstract: In processes for the hydrolysis of a methyl acetate with at least one of water and methanol in the presence of at least one Brønsted acid catalyst to produce acetic acid the performance of the catalyst is improved by using a methyl acetate feed in which the total amount of acetaldehyde and 1,1 dimethoxyethane impurities is maintained at 100 ppm wt or less calculated as mass equivalents of acetaldehyde.
    Type: Application
    Filed: December 11, 2018
    Publication date: April 18, 2019
    Inventors: Berian John Daniel, John Glenn Sunley, Russell Alan Taylor, Gareth Gerald Armitage
  • METHOD OF PRODUCING HYDROXYCINNAMIC ACIDS
    Publication number: 20190112254
    Abstract: A method efficiently produces hydroxycinnamic acids having a high quality, from a cellulose-containing biomass. More specifically, the method includes the steps of: obtaining an alkaline filtrate by allowing an alkaline aqueous medium to pass through a cellulose-containing biomass; obtaining a hydroxycinnamic acid extraction liquid by allowing the alkaline filtrate to repeatedly pass through the cellulose-containing biomass; and separating the hydroxycinnamic acid from the hydroxycinnamic acid extraction liquid.
    Type: Application
    Filed: March 28, 2017
    Publication date: April 18, 2019
    Inventors: Atsushi Minamino, Shigeyuki Funada, Hiroyuki Kurihara, Yuka Asahi, Takuya Kasahara, Katsushige Yamada
  • METHOD FOR PRODUCING METHYLMETHACRYLATE
    Publication number: 20190112255
    Abstract: The present invention relates to a process for producing methyl methacrylate, comprising the following steps: A) producing methacrolein and B) reacting the methacrolein obtained in step A) in an oxidative esterification reaction to give methyl methacrylate, characterized in that the two steps A) and B) take place in a liquid phase at a pressure of from 2 to 100 bar, and step B) is carried out in the presence of a heterogeneous noble-metal-containing catalyst comprising metals and/or comprising metal oxides.
    Type: Application
    Filed: October 16, 2018
    Publication date: April 18, 2019
    Applicant: Evonik Roehm GmbH
    Inventors: Steffen KRILL, Torsten BALDUF, Martin KOESTNER, Matthias GROEMPING, Alexander LYGIN, Rudolf BURGHARDT
  • POLYETHERAMINES BASED ON 1,3-DIALCOHOLS
    Publication number: 20190112256
    Abstract: Described herein is an etheramine mixture including at least 90% by weight, based on the total weight of the etheramine mixture, of an amine of Formula (I) and/or (II), wherein R1-R12 are independently selected from H, alkyl, cycloalkyl, aryl, alkylaryl, or arylalkyl, wherein at least one of R1-R6 and at least one of R7-R12 is different from H, wherein A1-A9 are independently selected from linear or branched alkanediyl groups having 2 to 18 carbon atoms, wherein Z1-Z4 are independently selected from —OH and linear —OCH2CH2CH2NH2, wherein the degree of amination of each of the etheramines of Formula (I) and Formula (II) is at least 50%, and wherein the sum of x+y is in the range of from 2 to 200, wherein x?1 and y?1; and x1+y1 is in the range of from 2 to 200, wherein x1?1 and y1?1.
    Type: Application
    Filed: March 14, 2017
    Publication date: April 18, 2019
    Inventors: Bjoern Ludolph, Sophia Ebert, Christian Eidamshaus, Stefano Scialla, Brian Joseph Loughnane, Karie Marie Henke, Gayle Marie Frankenbach, Jay Frank Nash, Michael Patrick Hayes, Manuel G. Venegas
  • Etheramine Compounds
    Publication number: 20190112257
    Abstract: Embodiments described herein provide a compound that may be used in a variety of applications such as corrosion inhibition, additives for metalworking, mining reagents, epoxy curatives, emulsifiers, fuel or lubricant additives, surfactant manufacture, acid scavengers and asphalt additives. The compound has the following structure: where R1 is a methoxy group, R2, R3, R4 and R5 are independently a hydrogen atom or an alkyl group, and R6 is an aminomethyl group.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 18, 2019
    Inventor: Donald H Champion
  • COMPOSITIONS AND METHODS FOR TREATING LIVER CANCER
    Publication number: 20190112258
    Abstract: Provided herein are compositions and methods of treating liver cancer by novel anticancer agents.
    Type: Application
    Filed: February 16, 2017
    Publication date: April 18, 2019
    Inventors: Sheng-Yung Liu, Chih-Ming Chen
  • METHOD FOR PRODUCING 1,5-PENTANEDIISOCYANATE IN THE GAS PHASE
    Publication number: 20190112259
    Abstract: The invention relates to a method for producing 1,5-pentanediisocyanate (PDI) by reacting 1,5-pentanediamine (PDA) with phosgene in the gas phase.
    Type: Application
    Filed: December 7, 2018
    Publication date: April 18, 2019
    Inventors: Josef Sanders, Martin Ehrig, Reinhard Halpaap, Manfred Keller-Killewald, Armin Schymura, Dietmar Wastian
  • CYCLIC PROCESS FOR PRODUCING ALKALI TAURINATE
    Publication number: 20190112260
    Abstract: There is disclosed a cyclic process for producing alkali taurinate from a solution comprising alkali tritaurinate by the ammonolysis in the presence of one or more catalysts. The ammonolysis reaction is catalyzed by alkali salts of hydroxide, sulfate, sulfite, phosphate, or carbonate. Taurine or alkali taurinate is prepared in a yield from 90% to quantitative.
    Type: Application
    Filed: December 4, 2018
    Publication date: April 18, 2019
    Inventor: Songzhou HU
  • CYCLIC PROCESS FOR PRODUCING ALKALI TAURINATE
    Publication number: 20190112261
    Abstract: There is disclosed a cyclic process for producing alkali taurinate from a solution comprising alkali tritaurinate and isethionate by the ammonolysis in the presence of one or more catalysts. The ammonolysis reaction is catalyzed by alkali salts of hydroxide, sulfate, sulfite, phosphate, or carbonate. Taurine or alkali taurinate is prepared in a yield from 90% to quantitative from alkali isethionate.
    Type: Application
    Filed: December 4, 2018
    Publication date: April 18, 2019
    Inventor: Songzhou HU
  • CYCLIC PROCESS FOR PRODUCING ALKALI TAURINATE
    Publication number: 20190112262
    Abstract: There is disclosed a cyclic process for producing alkali taurinate from a solution comprising alkali ditaurinate and alkali tritaurinate by the ammonolysis in the presence of one or more catalysts. The ammonolysis reaction is catalyzed by alkali salts of hydroxide, sulfate, sulfite, phosphate, or carbonate. Taurine or alkali taurinate is prepared in a yield from 90% to quantitative by successive ammonolysis.
    Type: Application
    Filed: December 4, 2018
    Publication date: April 18, 2019
    Inventor: Songzhou HU
  • USE OF ISOTHIOCYANATE FUNCTIONAL SURFACTANTS AS NRF2 INDUCERS TO TREAT EPIDERMOLYSIS BULLOSA SIMPLEX AND RELATED DISEASES
    Publication number: 20190112263
    Abstract: The present invention relates to methods and compositions for the prevention and treatment of keratin-based skin diseases. In particular, the application describes compositions and methods of treating a patient suffering from skin blistering comprising the use of phase II enzyme inducers and/or activity modifiers.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 18, 2019
    Inventor: Michael E. Silver
  • SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF
    Publication number: 20190112264
    Abstract: The invention provides compounds having the general formula I: (i) and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, ring B, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
    Type: Application
    Filed: March 28, 2017
    Publication date: April 18, 2019
    Applicants: GENENTECH, INC., XENON PHARMACEUTICALS INC.
    Inventors: Sultan CHOWDHURY, Christoph Martin DEHNHARDT, Thilo FOCKEN, Michael Edward GRIMWOOD, Ivan William HEMEON, Steven MCKERRALL, Daniel SUTHERLIN
  • SALT AND PHOTORESIST COMPOSITION CONTAINING THE SAME
    Publication number: 20190112265
    Abstract: A salt comprising a group represented by the formula (aa): wherein Xa and Xb independently each represent an oxygen atom or a sulfur atom, and X1 represents a C1-C12 saturated hydrocarbon group which has a moiety represented by formula (1a) or (2a):
    Type: Application
    Filed: October 10, 2018
    Publication date: April 18, 2019
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Tatsuro MASUYAMA, Satoshi YAMAMOTO, Koji ICHIKAWA
  • Substituted indoline derivatives as dengue viral replication inhibitors
    Publication number: 20190112266
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: March 31, 2017
    Publication date: April 18, 2019
    Inventors: Bart Rudolf, Romanie KESTELEYN, Pierre Jean-Marie, Bernard RABOISSON, Jean-François BONFANTI, Dorothée Alice, Marie-Eve BARDIOT, Arnaud Didier, M MARCHAND
  • SMALL MOLECULE N-(ALPHA-PEROXY) INDOLE COMPOUNDS AND METHODS OF USE
    Publication number: 20190112267
    Abstract: The invention relates to novel N-(?-peroxy)indole compounds of Formula I and methods for use. (I) The N-(?-peroxy)indole compounds described herein are useful for treating or preventing parastic infections, bacterial infections, and cancer in subjects. The methods include administering an N-(?-peroxy)indole compound as described herein to a subject. Also described herein are methods for synthesizing N-(?-peroxy)indole compounds.
    Type: Application
    Filed: May 10, 2017
    Publication date: April 18, 2019
    Inventors: Xinbo WANG, Zhiping LAI, Yupeng PAN, Kuowei HUANG, Zhigang WANG
  • mTORC1 MODULATORS
    Publication number: 20190112268
    Abstract: Provided herein, inter alia, are methods and compounds for inhibiting mTORC1 and for treating diseases associated with mTORC1 activity.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 18, 2019
    Inventors: Daniel K. Nomura, Roberto Zoncu, Allison M. Rpberts, Kelvin F. Cho, Yik Sham Clive Chung, Hijai Shin, Benjamin Croze
  • HYDROBROMIDE SALT OF N-(4-CHLORO-2-HYDROXY-3-((3S)-3-PIPERIDINYLSULFONYL)PHENYL-N'-(3-FLUORO-2-METHYLPHENYL)UREA
    Publication number: 20190112269
    Abstract: A compound which is the hydrobromide salt of N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N?-(3-fluoro-2-methylphenyl)urea, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 18, 2019
    Inventors: Francis Dominic SANDERSON, Sarah Mary VALLANCE
  • POLYMORPHIC FORM OF N-{6-(2-HYDROXYPROPAN-2-YL)-2-[2-(METHYLSULPHONYL)ETHYL]-2H-INDAZOL-5-YL}-6-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXAMIDE
    Publication number: 20190112270
    Abstract: The present invention relates to crystalline forms of N-{6-(2-Hydroxypropan-2-yl)-2-[2-(methylsulphonyl)ethyl]-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide, to processes for their preparation, to pharmaceutical compositions comprising them and to their use in the control of disorders.
    Type: Application
    Filed: April 25, 2017
    Publication date: April 18, 2019
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Tobias THALER, Johannes PLATZEK, Nicolas GUIMOND
  • PROCESSES FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS
    Publication number: 20190112271
    Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction that are conducted as a single pot process. 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement.
    Type: Application
    Filed: January 23, 2017
    Publication date: April 18, 2019
    Inventors: Kenneth E. STOCKMAN, Gregory T. WHITEKER, Erich J. MOLITOR, Nakyen CHOY
  • SYNTHETIC RETINOIDS FOR USE IN RAR MEDIATED CONDITIONS
    Publication number: 20190112272
    Abstract: There are described novel compounds of formula I: in which R1, R2, R3, R4, R5, X1 and X2 are each as herein defined, for use in the treatment or alleviation of an RAR miated condition: and methods related thereto.
    Type: Application
    Filed: April 6, 2017
    Publication date: April 18, 2019
    Inventors: Andrew Whiting, Roy Valentine, David Chisholm, Peter McCaffery, Iain Greig, Thabat Khatib
  • AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE
    Publication number: 20190112273
    Abstract: The present invention relates to an improved process for the preparation of Butorphanol tartrate of formula (I),
    Type: Application
    Filed: March 27, 2017
    Publication date: April 18, 2019
    Applicant: Hikal Limited
    Inventors: Rahul BHALERAO, R. SRIDHARAN, Shivaji Sadashiv KANDRE, Ganesh Suryakant DEORE, Kishorkumar Shivajirao KADAM, Dharnidhar MUNDHE
  • MCT4 INHIBITORS FOR TREATING DISEASE
    Publication number: 20190112274
    Abstract: Provided herein is a method for treating a monocarboxylate transporter MCT4-mediated disorder in a subject in need thereof. The method comprises the step of administering to the subject a compound of structural Formula I and/or a salt thereof. The treatment of the monocarboxylate transporter MCT4-mediated disorder may inhibit activity of MCT4, or a mutant thereof, sometimes with at least a 100-fold selectivity for MCT4 over MCT1.
    Type: Application
    Filed: December 17, 2018
    Publication date: April 18, 2019
    Inventors: Kenneth Mark PARNELL, John MCCALL
  • HETEROCYCLIC INHIBITORS OF MCT4
    Publication number: 20190112275
    Abstract: Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.
    Type: Application
    Filed: December 17, 2018
    Publication date: April 18, 2019
    Inventors: Kenneth Mark PARNELL, John MCCALL, Donna ROMERO
  • PU.1 INHIBITORS
    Publication number: 20190112276
    Abstract: Disclosed herein are inhibitors of PU.1. The inhibitors are useful for treating disorders associated with abnormal PU.1 levels and function.
    Type: Application
    Filed: December 20, 2018
    Publication date: April 18, 2019
    Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC., GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: W. David Wilson, David W. Boykin, Gregory Poon, Ulrich Steidl, Iléana Anthony-Debré
  • PROCESS FOR THE PREPARATION OF DIPHENYLPYRAZINE DERIVATIVES
    Publication number: 20190112277
    Abstract: The present invention relates to a process for the preparation of amorphous Selexipag from Selexipag crystalline salts using a solvent.
    Type: Application
    Filed: April 1, 2017
    Publication date: April 18, 2019
    Applicant: HONOUR (R&D)
    Inventors: Bandi Parthasaradhi Reddy, Kura Rathnakar Reddy, Bandi Vamsi Krishna, Kesireddy Subhash Chander Reddy, Kancharla Rajendar Reddy
  • PROCESS FOR THE PREPARATION OF A DUAL-ACTING ANGIOTENSIN RECEPTOR-NEPRILYSIN INHIBITOR COMPOUND
    Publication number: 20190112278
    Abstract: The present invention relates to a process for preparing amorphous form of Sacubitril/Valsartan sodium salt of Formula-II and pharmaceutical composition comprising thereof.
    Type: Application
    Filed: December 4, 2018
    Publication date: April 18, 2019
    Inventors: Bandi PARTHASARADHI REDDY, Kura RATHNAKAR REDDY, Adullla VENKAT NARSIMHA REDDY, Bandi VAMSI KRISHNA
  • 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20190112279
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, JR., David S. Millan, Matthew W. Martin, Kenneth W. Bair
  • 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20190112280
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, JR., David S. Millan, Matthew W. Martin, Kenneth W. Bair
  • 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20190112281
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, JR., David S. Millan, Matthew W. Martin, Kenneth W. Bair
  • 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20190112282
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, JR., David S. Millan, Matthew W. Martin, Kenneth W. Bair
  • 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20190112283
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, JR., David S. Millan, Matthew W. Martin, Kenneth W. Bair
  • 3-ARYL-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
    Publication number: 20190112284
    Abstract: The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Application
    Filed: December 17, 2018
    Publication date: April 18, 2019
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, JR., David S. Millan, Matthew W. Martin
  • Aminothiazole Derivatives Useful As Antiviral Agents
    Publication number: 20190112285
    Abstract: The invention relates to novel compounds of the Formula (I), to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
    Type: Application
    Filed: April 5, 2017
    Publication date: April 18, 2019
    Inventors: Gerald Kleymann, Christian Gege
  • SALT AND PHOTORESIST COMPOSITION CONTAINING THE SAME
    Publication number: 20190112286
    Abstract: A salt comprising a group represented by the formula (aa):
    Type: Application
    Filed: October 8, 2018
    Publication date: April 18, 2019
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Tatsuro MASUYAMA, Natsuki OKADA, Koji ICHIKAWA
  • COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
    Publication number: 20190112287
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Application
    Filed: March 30, 2018
    Publication date: April 18, 2019
    Inventors: Brian W. Metcalf, Zhe Li, Qing Xu, Stephen L. Gwaltney, II, Jason R. Harris, Calvin W. Yee