Abstract: The present disclosure provides heteroarene-based drug derivatives having a “clickable” ketone group, as well as conjugates of said drug derivatives with targeting moieties capable of binding to extracellular antigens; and pharmaceutical compositions comprising them.

Abstract: A bifunctional polypeptide comprising a specific binding partner for a peptide-MHC epitope, such as an antibody or T cell receptor, and an immune effector, such as an antibody or a cytokine, the immune effector part being linked to the N-terminus of the peptide-MHC binding part.

Abstract: A system and method for evaluating wound healing dressings, treatments, and other variables. The present invention includes in vitro systems and methods for testing wound dressing materials for bacterial control, moisture control, and surface contact properties. The present invention further includes in vivo systems and methods for testing wound dressings, treatments, and other variables utilizing arrays of wound wells on an experimental subject animal. Wound arrays allow for different wound healing variables to be tested with numerous experimental trials within the same subject animal, giving reliable results and reducing the number of subject animals required for testing.

Abstract: This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (DNIRA).

Abstract: Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGaylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described.

Abstract: The present disclosure relates to a method for imaging cancer by administering to a patient a labeled chelating compound and an unlabeled chelating compound.

Abstract: Compositions and methods are described for stabilizing a radio-iodinated monoclonal IgG antibody for up to 17 days against radiolytic decomposition. The stabilized radiolabeled murine antibody binding the CD45 antigen expressed on various forms of lymphomas is useful as a radiotherapeutic and diagnostic agent in the treatment of human malignancies of hematopoietic origin, including lymphomas.

Abstract: The invention relates to a method (S) for generating a plurality of cold-plasma jets at atmospheric pressure in order to treat a target (2), wherein said method includes the following steps: producing (S1) a primary cold-plasma jet (3) at atmospheric pressure using a plasma source (10); placing (S2) a substrate (20, 21, 30, 32, 34) near the target (2) to be treated, said substrate (20, 21, 30, 32, 34) including at least two through-holes; and passing (S3) the plasma through the through-holes (22) of the substrate (20) such as to generate at least two secondary cold-plasma jets (4) at atmospheric pressure.

Abstract: Dispensers for fragrance and chemical compounds include paperboard materials and unique shapes to allow for simplified production and use of the dispensers in various environments.

Abstract: A diaper and a method of manufacturing thereof that include a composition located on, in, or near an area of the diaper that will contact skin of an individual when the individual is wearing the diaper. The composition is formulated to reduce the risk of formation of a rash or pressure ulcer on the skin of the individual.

Abstract: A surgical sealant comprising a first agent containing a hydrophobically-modified gelatin derived from a cold-water fish, and a second agent containing a water-soluble molecule for crosslinking, wherein the water-soluble molecule for crosslinking is at least one kind selected from the group consisting of poly acids and acid anhydrides having two or more active ester groups, and aldehyde compounds having two or more aldehyde groups, the hydrophobically-modified gelatin derived from a cold-water fish is a gelatin in which at least a part of amino groups of side chains of a gelatin derived from a cold-water fish has been substituted by hydrophobic groups, and the hydrophobic groups are linear chain aliphatic groups each having 8 to 18 carbon atoms, with a substitution rate (number of moles of hydrophobic groups/(total number of moles of hydrophobic groups and reactive amino groups in gelatin)×100) of 3 to 20 mol %.

Abstract: Provided is an electroactive structure and method for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.

Abstract: This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.

Abstract: Provided are a cell carrier for skin tissue regeneration using chitooligosaccharide and a method for producing the same. The cell carrier according to the present invention includes fish-derived collagen (FC), alginate (A), and chitooligosaccharide (COS1) of 1 to 3 kDa, and thus has excellent biocompatibility with dermal fibroblasts and has an excellent effect of being utilized as a cell carrier for skin tissue regeneration.

Abstract: A flushable catheter assembly that includes at least one shrinkable portion that shrinks from a first configuration to a second compact configuration to reduce the size of the catheter assembly for passage through the sewer system. The flushable catheter may also be made from a water disintegratable polymer that dissolves, degrades or hydrolyzes while within the sewer system.

Abstract: Coatings, materials, and devices with biohealing properties are described. A biohealing coating may include a base material and biohealing particles. The base material may include a polymer. The biohealing particles may include one or more of metal particles, alloy particles, metal oxide particles, carbon particles, carbide particles, and nitride particles. The biohealing coating may be applied to an implantable device. A biohealing material may include a base material in bulk form and biohealing particles. The biohealing material may be used to manufacture an implantable device. An implantable device may include one or both of a biohealing coating and a biohealing material.

Abstract: Disclosed are a nanofiber mat, a manufacturing method thereof, and applications thereof as a mat for cell culturing or as a barrier membrane for guided bone regeneration (GBR). The nanofiber layer includes a nanofiber layer and a reinforcement pattern that is disposed on the nanofiber layer and adhesively connected with the nanofiber layer. The nanofiber layer and the reinforcement pattern are combined with each other by at least one of the melting-solidification of at least a part of the nanofiber layer together with the reinforcement pattern, the dissolution-solidification of the same, and the penetration of a part of the reinforcement pattern into the nanofiber layer, followed by solidification.

Abstract: Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms are disclosed. The systems include an insertable medical device and an in-situ forming foam that is formed from a polymer that reacts in an aqueous environment. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.

Abstract: A crystallized bioabsorbable polymer scaffold comprises a polymer composition of poly (L-lactide-co-tri-methylene-carbonate) or poly (D-lactide-co-tri-methylene-carbonate) or poly (L-lactide-co-?-caprolactone) or poly (D-lactide-co-?-caprolactone) in the form of block copolymers of blocky copolymers, wherein the scaffold is cold-bendable.

Abstract: An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a first component having a first substrate and a second component having a second substrate. The second component is positioned within the first component. One of the first and second substrates includes a hemostatic agent and the other of the first and second substrates includes an active pharmaceutical ingredient. Kits, systems and methods are disclosed.

Abstract: A waste collection unit (40) with a primary display (106) on which information about the operation of the unit is presented. In addition to the primary display there is a light assembly (662) adjacent the fitting (614) to which a suction line is attached. The light assembly emits light of selectively colors or in a selected pattern based on an operation state of the waste collection unit.

Abstract: A manually-actuated, constant reduced-pressure apparatus for use with a reduced-pressure system for treating tissue at a tissue site includes a flexible, collapsible member that is operable to move between a compressed position and an extended position. The collapsible member may be disposed between a carrier member and a slider member that move between a compressed position and an extended position. The carrier member and slider member are urged away from each other by a constant-force biasing member, e.g., a constant force coil spring. As the apparatus moves from the compressed position to the extended position, a constant reduced-pressure is generated and delivered to a reduced-pressure port. Methods of manufacturing a manually-actuated, constant reduced-pressure apparatus and methods of treating a tissue site are also provided.

Abstract: A system for separating a flow of matter is shown and described. The system includes one or more flow separation devices, one or more surgical instruments, and one or more suction sources. In some embodiments, the flow of matter comprises biological material. In some embodiments, the flow of matter comprises surgical waste.

Abstract: Systems, devices, and methods for treating a tissue site on a patient with reduced pressure are presented. In one instance, a reduced-pressure interface includes a conduit housing having a cavity divided by a dividing wall into a reduced-pressure-application region and a pressure-detection region. The reduced-pressure interface further includes a reduced-pressure port disposed within the reduced-pressure-application region, a pressure-detection port disposed within the pressure-detection region, and a base connected to the conduit housing, the base having a manifold-contacting surface. The dividing wall includes a surface substantially coplanar with the manifold-contacting surface.

Abstract: A left ventricular cardiac assist pump includes an inlet opening and a discharge opening aligned in an axial direction. The pump includes a casing spaced from a stator and impeller, with at least one connecting spacer connecting the casing and the stator. The impeller is configured to direct the blood towards the casing and the discharge opening, so that blood flows through the pump principally between the casing and the rotor-stator assembly.

Abstract: The present disclosure provides for methods and systems for determining heart rate of a patient. Based on motor current signals of a ventricular assist device (VAD), each of first, second and third events in the measured current signal may be detected, the first event being indicative of a rise or fall in the current signal, the second event being indicative of a rise or fall in the current signal in the opposite direction as the first event, and the third event being indicative of a rise or fall in the current signal in the same direction as the first event. A timer counter may be initiated upon detection of the first event, and an elapsed time may be measured upon detection of the third event. Heart rate may be determined based on the elapsed time of the timer counter.

Abstract: A fluid preparation system has a sealed sterilized fluid circuit with a sealed sterilized container with a conductivity sensor in communication with an interior of said container. Further, at least one sealed connector is adapted for adding fluid to said container, and at least one sealed connector is adapted for removing fluid from said container. The conductivity sensor is contained in a test line in communication with said interior and is adapted to be connected to a source of suction thereby to draw a sample of contents of said container. Furthermore, the test line may have a check valve to prevent ingress of contaminants into said container, and the sealed connector is adapted for adding fluid to said container and may have an inline sterile filter. Furthermore, the system may have a controller that controls pumping actuators.

Abstract: The degassing system can include a degassing vessel and can utilize a vacuum pump and a fluid pump located downstream of the degassing vessel to control the pressure within the degassing vessel in order to control the concentration of gases in fluid exiting the degassing system. The degassing system can further comprise sensors in communication with the pumps to control the rate of flow and pressure through the degassing system. The degassing system may be placed in a dialysate flow path to remove dissolved gases including carbon dioxide from the dialysate.

Abstract: A device for forming a fistula between blood vessels includes a tubular body having a central lumen, a flange attached to the tubular body and projecting outwardly from an outer body surface, and one or more vanes projecting inwardly into the lumen so as to induce helical flow in blood passed through the lumen between first and second vessels joined via the fistula.

Abstract: An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is configured to connect to an artery of the subject and the second end portion is configured to connect to a vein of the subject such that blood flows through the at least one conduit; and at least one cannulation chamber positioned between the first end portion and the second end portion of the at least one conduit. The chamber includes: an elongated housing having an inlet and an outlet, a posterior wall, a pair of sidewalls, and an open anterior portion defining a cannulation port; and a self-sealing material extending across the cannulation port. The posterior wall and the sidewalls of the housing are formed of a substantially rigid material.

Abstract: The present invention relates to a method for querying a specification feature arranged in, at or on a medical technical functional means, the method comprising the step of: querying the specification feature by means of a medical device functionally coupled to or to be coupled to the medical technical functional means or by means of a device or means connected to or being arranged in signal transmission with the medical technical treatment apparatus. The invention further relates to a medical technical functional means, a medical device and a control unit. Furthermore, the present invention relates to a digital storage medium, a computer program product and a computer program.

Abstract: A storage portion forming a storage space 10, includes an inclined inner wall portion 20 that is connected to a base portion so that the diameter of the inclined inner wall portion gradually decreases; a concave portion 22 is formed at a part of the inclined inner wall portion; and the concave portion 22 includes a concave portion side surface 22b that is connected to a concave portion bottom surface 22a. The concave portion 22 is formed at a position, where the concave portion crosses an interface S between the specimen centrifuged during rotation and air, in a radial direction with respect to the central axis; and the maximum width of the concave portion 22 in a circumferential direction around the central axis is included in a range of 2 mm to a length of 20% of the whole circumference.

Abstract: A system and method to irrigate a user's auditory canal. A fluid can be dispensed from a reservoir through a fluid path and out through openings of a delivery element into the auditory canal. A pump may be used to facilitate the process of dispensing the fluid. The fluid can be delivered to the user's auditory canal for a predetermined period of time. Such a time period may be user selectable. The discharge from the irrigation is removed from the user's auditory canal via a discharge port located on the delivery element. The discharge exits the delivery element and proceeds to a discharge reservoir via a discharge path. A vacuum may be used to generate a negative pressure to facilitate the removal of the discharge from the auditory canal.

Abstract: A syringe assembly includes a plunger assembly, a syringe body, and a needle. The plunger assembly includes a plunger rod, a spring, a plunger base, and a plunger plug. The plunger rod includes a first end member having a first stepped part positioned in an inner wall thereof, a second end member, and a first accommodating room. The plunger base includes a plunger body, a projection, a second stepped part, a plunger member, and a locating member. The plunger body is received in the first accommodating room, and the projection abuts against the first end member. The spring is arranged around the plunger body and positioned between the first stepped part and the second stepped part. The plunger plug is mounted to the second end member, and defines a fixing groove. The syringe body includes a needle cannula, a needle base, a fixing pole, and a fixing valve. The plunger assembly is received in the needle cannula. The needle base is mounted to the needle cannula. The fixing valve is received in the needle base.

Abstract: The invention provides for method of operating a medical instrument (100, 200, 400, 500, 600, 700) comprising a battery powered medical appliance (104) and a control unit (102). Both have Bluetooth communication modules. A first memory of the medical appliance contains a onetime password (210) and of a password-authenticated key agreement algorithm (212). The control unit has a second memory (223) with an implementation of the password-authenticated key agreement algorithm (212?). The method comprises entering (300) the onetime password into the data entry interface (140, 221, 504, 604) of the control unit. The method further comprises generating (302) a Bluetooth encryption key (218) by the medical appliance and the control unit with the onetime password by exchanging data across the wireless communication channel by executing the password-authenticated key agreement algorithm. The method further comprises storing (304) the Bluetooth encryption key in the first memory.

Abstract: A method of securing an assembly of a drug delivery system, comprising: configuring at least a first component and a second component of the assembly in a closed configuration ready for placement into the drug delivery system; installing an assembly key including a locking element on the assembly to secure the assembly in said configuration; and, transporting the assembly with the assembly key installed.

Abstract: A drug delivery device (100), including a body (104, 116) having a reservoir (164, 176) disposed therein for containing a medicament and an injection needle (152) for penetrating the skin of a patient, the needle (152) providing a path for the medicament between the reservoir (164, 176) and the patient. The device (100) also includes a needle cover (114) for selectively covering the injection needle (152), an adhesive (264) for selectively adhering the device to the patient, a release liner (500) for selectively covering a patient side of the adhesive (264), and a connecting means (112, 520, 512, 508, 524) for connecting the needle cover (114) and the release liner (500) such that removal of one of the needle cover (114) and the release liner (500) from the device (100) removes the other one of the needle cover (114) and the release liner (500).

Abstract: Method and system for controllably administering and/or withdrawing fluid from a patient. In one embodiment, the system may include a needle assembly, an ultrasound imager, a fluid supply storage unit, a waste storage unit, a fluid pump, and a foot pedal assembly. A syringe may serve as the fluid supply storage unit and the waste storage unit. The pump may include a bi-directional motor and a gear coupled to the motor. The gear may be engageable with a rack on the syringe plunger to drive the plunger either for fluid aspiration or infusion. Depression of one portion of the foot pedal assembly causes the motor to drive the gear in one direction, and depression of another portion of the foot pedal assembly causes the motor to drive the gear the other direction. The system may include a control device to keep pressure in the fluid path from exceeding a limit.

Abstract: A fluid delivery device comprising a fluid reservoir; a transcutaneous access tool fluidly coupled to the fluid reservoir; and a drive mechanism for driving fluid from the reservoir, the drive mechanism comprising a plunger received in the reservoir; a leadscrew extending from the plunger; a nut threadably engaged with the leadscrew; a drive wheel; and a clutch mechanism coupled to the drive wheel, wherein the clutch mechanism is configured to allow the nut to pass through when disengaged and is configured to grip the nut when engaged such that the drive wheel rotates the nut to advance the drive rod and the plunger into the reservoir.

Abstract: An insertion device to assist in accessing an access port that has been subcutaneously implanted in the body of a patient is disclosed. The implanted access port is accessed by a needle of a needle assembly, such as a needle-based infusion set. In one embodiment, the insertion device comprises a body that includes a stabilizing portion and a guide portion. The stabilizing portion stabilizes a position of the implanted access port when the body is placed on the skin of the patient atop the implanted access port. The guide portion guides a needle of the needle assembly along a predetermined path such that the needle transcutaneously pierces a septum of the implanted access port.

Abstract: MicroElectroMechanical System (MEMS) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., PEGDA), which are photopolymerizable in the presence of crosslinkers and photoinitiators. By using PEGDA monomers of different molecular weights and at different percentages, the mechanical properties of the polymerized gels and their respective permeabilities can be tuned. This spatial variation in properties and permeabilities can lead to different functionalities between different portions of the hydrogel MEMS device. Portions of the hydrogel device may be remotely actuated by applying wave energy, for example, a magnetic field, high intensity focused ultrasound, and/or infrared radiation. The remote actuation can allow the device to be actuated in vivo, for example, to allow the device to deliver a drug or other substance at a desired time and/or desired location within a patient.

Abstract: The invention provides a modular tubing system with a set of tubing segments that can be configured to provide a desired flow rate. In the modular systems described herein, multiple tubes with pre-set flow rates are attached either in-series or in parallel to allow the user to vary the flow rate of the therapy. The modular systems described herein may be used in connection with a constant pressure pump for subcutaneous administration of therapeutic agents.

Abstract: An apparatus comprises a body having an opening at a first end of the body. A plunger control grip is slidably coupled to a portion of the body circumference and configured to couple to a syringe plunger. The apparatus further comprises a cover pivotably coupled to the first end of the body, wherein in an open position the cover exposes a cavity configured to receive a syringe. A locking mechanism is pivotally secured to the cover, wherein the locking mechanism is configured to prevent forward movement of the plunger control grip when in a locked position and to enable forward movement of the plunger control grip when in an unlocked position. The unlocked position is activated by external contact with the locking mechanism and forward movement is in the direction toward the first end of the body.

Abstract: Described is a syringe housing at least one removable carpule containing at least two injectable solutions and having a mixing chamber for mixing two injectable solutions during administration of the solutions, and methods of using the syringe.

Abstract: The present invention is generally directed to an injection device for selecting and dispensing a number of user variable doses of a medicament.

Abstract: An assembly for a drug delivery device includes a first member and an attenuation member. The first member includes a main body and an elastically displaceable feature connected to the main body. The attenuation member mechanically cooperates with the elastically displaceable feature to influence the force which has to be exerted on the elastically displaceable feature to displace the elastically displaceable feature elastically with respect to the main body. An attenuation member can be used in a drug delivery device to tune the force required to elastically displace an elastically displaceable feature of a first member of the drug delivery device by bringing the attenuation member into mechanical cooperation with the elastically displaceable feature.

Abstract: An expanding plunger rod for a syringe is configured to transition from a packaged configuration to an expanded configuration for operation. The rod includes a substantially cylindrical outer sleeve having a closed-off bottom end and an open upper end, and an inner rod having a lower end and an upper end. The inner rod is slidably disposed coaxially within the outer sleeve. In the packaged configuration, the inner rod is nested within the outer sleeve. In the expanded configuration, the inner rod is disposed substantially axially above the outer sleeve, and the inner rod locks axially in place to prevent transition from the expanded to the packaged configuration.

Abstract: The present disclosure relates to a drive mechanism for a medicament delivery device according to the disclosure comprises a compression member comprising a first cavity containing a first volume of fluid, said compression member also comprising a second cavity containing a second volume of fluid; a passage for fluid communication between the first cavity and the second cavity; a first movable piston arranged to seal the first cavity; a second movable piston arranged to seal the second cavity; wherein movement of the first movable piston or of the second movable piston, by an applied force, causes a relative change of volume between the first volume of fluid and the second volume of fluid, via a fluid flow through said passage, such that the respective second movable piston or the first movable piston is also moved.

Abstract: A drug delivery device for dispensing of a dose of a medicament includes an elongated body extending in an axial direction, a cartridge holder to accommodate a cartridge at least partially filled with the medicament and having an axially displaceable piston, and a piston rod to operably engage with the piston of the cartridge to displace the piston in axial distal direction. The drug delivery device further includes a coupling member connected with the cartridge holder and being axially displaceably arranged in the body for retracting the cartridge holder into the body during setting of a dose.

Abstract: A syringe includes a barrel having an internal surface defining an internal bore therein; a plunger having a distal end disposed within the internal bore of the barrel, and a proximal end disposed outside the internal bore of the barrel, the proximal end of the plunger being opposite the distal end of the plunger along a longitudinal direction; and a dose divider. The dose divider includes a divider flange extending at least partly in a radial direction, the radial direction being perpendicular to the longitudinal direction, the divider flange having a distal surface that faces the barrel, the distal surface of the divider flange bearing on the proximal end of the plunger, and a concave shell extending away from the distal surface of the divider flange along the longitudinal direction.