Abstract: A data collection device for attachment to an injection device, such as an injector pen, includes a sensor arrangement to detect movement of a movable component of the injection device relative to the data collection device during delivery of a medicament by the injection device, and a processor arrangement configured to, based on said detected movement, determine a medicament dosage administered by the injection device. The processor arrangement may monitor the time that has elapsed since the medicament dosage was administered, and control a display to show the mediacament dosage and elapsed time to provide a memory aid to the user. In an example embodiment, the sensor arrangement includes an optical encoder and the movable component includes a plurality of light barrier formations. The movable component may be a number sleeve that provides a visual indication of a dose programmed into the injection device.

Abstract: A drive mechanism of a drug delivery device for dispensing of a dose of a medicament, includes an elongated housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge to displace the piston in axial distal direction, a drive sleeve rotatably supported in the housing at least in a dose incrementing direction against the action of a spring element, and a ratchet mechanism to rotatably fix the drive sleeve relative to the housing. A first ratchet body has a first and a second ratchet element to alternately engage with a toothed profile of a second ratchet body. One of the first and second ratchet bodies is operably engaged with the housing and wherein the other one of the first and second ratchet bodies is operably engaged with the drive sleeve.

Abstract: A supplemental device for attachment to an injection device, the supplemental device having a housing containing at least two electromechanical switches each having an open state and a closed state and a protrusion associated with each switch configured to protrude from the housing so as to contact a rotatable surface of the injection device while the supplemental device is attached to the injection device; and a processor arrangement configured to detect a change in the state of each of the switches; and to determine a direction of rotation of the rotatable surface of the injection device from the detected state changes.

Abstract: The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.

Abstract: An assembly for a drug delivery device (200) is provided, the assembly comprising a needle mounting feature (1), a needle detector (2), a housing (3) and a movable feature (4) which is movably connected to the housing (3) and movable with respect thereto between a first position and a second position different from the first position. The needle detector (2) is configured to detect whether a needle (101) is mounted to the needle mounting feature (1). The assembly is further configured such that when a needle (101) is mounted to the needle mounting feature (1), the movable feature (4) is in the second position and when the needle (101) is not mounted to the needle mounting feature (1), the movable feature (4) is in the first position.

Abstract: The present invention relates to a protection device (1) intended to at least partially cover the needle (2) of an injection device, comprising: a support (3) of the protection device (1), a sleeve (4) movable axially in translation with respect to the support (3), an arrangement (14) for returning the sleeve (4) from an injection position to a protection position, an axial guidance arrangement (29, 30) for preventing the sleeve (4) from pivoting with respect to the support (3), one peg (6) directly and at least elastically, coupled longitudinally to the support (3) or the sleeve (4) and housed in a passageway (10) defining a first section (11) and a second section (12) followed by the peg (6) from a storage position to the injection position and then to the protection position, and a safety arrangement (21; 36, 34, 35) part of which being elastically deformable, arranged in a way as to prevent the peg from returning from the second section to the first section.

Abstract: An apparatus and method for delivery of fluids, particularly biological, reactive fluids. The apparatus provides an opening when force is acted on the apparatus, and closure when no force is acted thereon. The apparatus provides a cleaning mechanism to remove fluids and other materials from a mixing space after use.

Abstract: A fluid injection system and a fluid verification system for confirming that a syringe, containing a fluid for injection, is fully filled with fluid and neither has free space (i.e., air) near the distal end thereof when the syringe is provided in an upright position nor contains air bubbles. Imaging processing techniques and systems are also provided to determine various injection parameters and to verify the type and certain properties of fluid that is present within a syringe.

Abstract: An aerosol generating apparatus with interchangeable parts is disclosed. The aerosol generating apparatus includes a holder for accommodating a structure plate and an oscillation generator. The structure plate includes an inlet surface, an outlet surface, a projection extending from the face of the inlet surface, and a through hole. The through hole penetrates the structure plate. The oscillation generator is coupled with and vibrates the structure plate. A reservoir for providing a liquid medicament is also disclosed. The reservoir is detachably engaged with the holder and includes a membrane with a plurality of orifices. During aerosolization, the liquid medicament passes through the plurality of orifices. When the reservoir is engaged with the holder, the membrane of the reservoir is in contact with the projection extending from the face of the inlet surface. In addition, the oscillation generator vibrates the membrane through the projection on the inlet surface.

Abstract: A disposable medical grade tank and mod assembly for dose controlled smokeless administration of a plurality of vaporized chemicals, and method of use thereof.

Abstract: A CPR template for use by a rescuer in performing CPR includes a pliable mask portion, a pliable body portion and a connecting link that joins the mask portion to the body portion. The mask portion is adapted to be placed over the face of a person, and includes a mouthpiece extending therethrough for use in administering rescue breaths. The body portion has a sternal diagram displayed thereon, and an instructional area in which CPR instructions are displayed.

Abstract: An airway management device is provided that may adjust the inflation level of a cuff associated with an endotracheal tube. The cuff inflation may be adjusted in response to an increase in carbon dioxide levels above the cuff, which may indicate a poor seal of the cuff against the tracheal walls, as well in response to a measured intracuff pressure. By using information about the seal quality of the cuff together with information about the cuff pressure, the inflation of the cuff can be adjusted to minimize cuff inflation pressure while maintaining a high quality tracheal seal.

Abstract: A patient interface system for delivery of a supply of air at positive pressure to the entrance of a patient's airways for treatment of sleep disordered breathing includes an air delivery tube connected to a flexible portion of a plenum; a vent structure having sufficient rigidity to support its own weight under gravity and/or not to block or fold under tube movement or tube drag; and a patient interface structure. The patient interface structure includes a seal forming structure arranged on a top portion of the plenum; and a seal positioning and stabilizing structure connected to a flexible portion of the plenum. The seal-forming structure is substantially decoupled from a tube drag force.

Abstract: A coupling assembly for a respiratory interface device support assembly and a respiratory interface device mask is provided. The respiratory interface device support assembly has at least one strap structured to be coupled to each lateral side of the respiratory interface device mask. The coupling assembly includes a first rotatable coupling component structured to be coupled to the support assembly and having a first rotation limiting structure, and, a second rotatable coupling component structured to be coupled to the mask and having a second rotation limiting structure. When coupled, the first rotatable coupling component first rotation limiting structure and the second rotatable coupling component first rotation limiting structure limit the rotation of the first rotatable coupling component relative to the second rotatable coupling component.

Abstract: A mask assembly for delivering pressurized gas to a patient comprising a mask having an inspiratory port and an expiratory port located on generally opposite sides, wherein said ports are sized, oriented, positioned, and/or spaced apart a sufficient distance to allow a cross-flow of pressurized gas to flow through the mask assembly; an outlet limb connected to the expiratory port and having an aperture in pneumatic communication with the breathing chamber; the aperture size being variable between a first, open configuration and at least one second configuration that is different from the first. A ventilation system for delivering pressurized gas to a patient comprising a seal formed with the patient's airways and in pneumatic communication with a plenum chamber; an exchanger positioned at least partially within the plenum chamber, and in pneumatic communication with inspiratory and expiratory flow paths, to recover heat and/or moisture from gas exhaled by the patient.

Abstract: A breathing mask has a mask body surrounding a cavity that is open towards one side and is intended for coming into contact with a human face around the mouth and/or nose. A valve arrangement is provided in the mask body with an inspiration valve, for controlling the flow of gas from a port for a breathing gas feed device for providing a breathing gas into the cavity, and an exhalation valve for controlling the flow of gas from the cavity into the surrounding atmosphere. An emergency breathing valve, controlling gas flow from the atmosphere surrounding the breathing mask into the cavity, has a pressure threshold, to allow gas flow, that is lower than an inhalation valve pressure threshold. The pressure thresholds at which the respective inhalation valve and the emergency breathing valve open are coordinated by the closing element being designed as a separate component of the valve arrangement.

Abstract: The present invention comprises an apparatus for ascertaining a personal tinnitus frequency consisting of an audio signal generator unit and an associated audio signal earphone, which apparatus provides a first audio signal whose frequency is continuously adjustable. The invention is characterized in that compensating means are provided in order to eliminate ambient noise through active noise reduction.

Abstract: A system for influencing the senses of a person in a room for measuring and/or influencing physiological parameters of the person is provided. The person is substantially stationary and lying in the room during the measurement and/or influencing. The system includes a sound insulating apparatus for screening off acoustically active devices with respect to the person. The acoustically active devices serve for measuring and/or influencing the physiological parameters in the room, and an optical display apparatus for offering optical stimuli and/or signals for the person in the field of view of the person.

Abstract: Embodiments include methods, systems, and computer program products for detection and remediation of anxiety. Aspects include receiving an anxiety indicator. Aspects also include analyzing the anxiety indicator to determine whether an anxiety level exceeds an anxiety threshold. Aspects also include, based upon a determination that the anxiety level exceeds the anxiety threshold, selecting a first sound. Aspects also include outputting the first sound. Aspects also include receiving an anxiety feedback. Aspects also include determining, based upon the anxiety feedback, whether the anxiety level is decreasing.

Abstract: An exterior bowl has a closed bottom, an open top, and a side wall there between. An exterior annular flange extends radially outwardly from the open top of the exterior bowl. An interior bowl has an open bottom, an open top, and a side wall there between. An interior annular flange extends radially outwardly from the open top of the interior bowl. The open bottom of the interior bowl is coupled to the closed bottom of the exterior bowl to create an annular chamber between the side wall of the exterior bowl and the side wall of the interior bowl. Tubing within the chamber in a spiral configuration removably receives a plurality of surgical wires. Each of the surgical wires has an upper extent extending upwardly and out of the chamber for being grasped and extracted from the tubing.

Abstract: Apparatuses of the type broadly applicable to numerous medical applications in which it is desirable to insert one or more steerable or non-steerable catheters or similar devices into a working channel of an associated device, such as an endoscope, catheter, etc., or passageway of a patient, are disclosed. The apparatuses may include catheters having a dedicated guide wire channel and one or more of the following: viewing capabilities, a working channel, and auxiliary channels, such as insufflation/irrigation channels. The catheters may include a guide wire channel that is configured to provide the catheter or other device with rapid exchange capabilities.

Abstract: A probe for traversing a tubular passage includes an introducer to be supported at an entrance to the tubular passage. The probe also includes a probe tip to traverse the tubular passage, and a tube with an inflatable tube segment. In some embodiments, the inflatable tube segment is storable in the probe tip. The inflatable tube segment is configured to be inflated to push the probe tip away from the introducer toward an end of the tubular passage. In some embodiments, the probe includes a sealing mechanism, where the sealing mechanism can be positioned between the inflatable tube segment of the tube and the introducer to maintain the inflatable tube segment in a deflated configuration until inflation of the inflatable tube segment.

Abstract: Some embodiments of a medical device anchor system include an anchor device that secures a medical instrument (such as a catheter or the like) in place relative to a skin penetration point using subcutaneous anchors. In some implementations, the medical instrument can be coupled to the anchor device using a snap-lock cap mechanism.

Abstract: The invention provides compositions and methods for the treatment and/or reversal of an edema, e.g., including a central nervous system (CNS) edema, e.g., a brain or a spinal edema, edema in a burned or an injured tissue such as skin, or any tissue edema. In alternative embodiments, the invention provides compositions and methods for a direct treatment and reversal of an edema, e.g., CNS, brain or spinal edema, including a membrane transport device, in vitro and in vivo characterization of edema, and the sensitive early optical detection of the edema, e.g., tissue, CNS or cerebral edema.

Abstract: Medical devices and methods of using medical devices are described herein. More particularly, the disclosure relates to introducers suitable for providing access to a body vessel and methods of using introducers. An example introducer comprises a sheath and a dilator moveably disposed within the sheath. The distal end of the dilator has a closed configuration and an open configuration and movement between the open and closed configurations can be accomplished by applying a proximally-directed force on the sheath such that the sheath moves in a proximal direction relative to the dilator.

Abstract: A lotion application machine for allowing automatic application of a lotion to the body of a user is provided. The lotion application machine has a rotatable platform, on which the user can stand and be rotated while the lotion is being applied. The lotion can be applied evenly to the entire body of the user.

Abstract: The present invention provides, inter-alia, applicators comprising an array of microneedles for administration of a composition comprising a biocompatible ceramic material effective in augmentation of skin. In particular, the applicators and methods of the present invention are aimed at filling the undesired lines, wrinkles, depressed scars and folds of a subject's skin and restoring youthful fullness to the skin.

Abstract: This disclosure relates to swellable needles that include a proximal end portion and a swellable distal end portion. Upon exposure to a liquid, the needles are configured to undergo a shape change from a first configuration in which the width of the needle is tapered from the proximal end portion to the distal end portion to a second configuration in which the distal end portion is more swollen than the proximal end portion. The swellable needles can be double layer swellable needles or single material swellable needles.

Abstract: A device for providing an implanted injection site capable of delivering a therapeutic substance or medication into the subarachnoid space. The receiving compartment is implanted under the skin adjacent the spine. Injections may be made repeatedly into the membrane for delivering the therapeutic substance without the need for repeated spinal taps. Medications such as immunoglobulin may be administered intrathecally directly into the central nervous system bypassing the blood brain barrier providing more concentrated, effective and less costly treatment of diseases such as Alzheimer's disease. Another embodiment is a method of administering an immunoglobulin composition having a four to six percent concentration incrementally over time by alternately removing cerebrospinal fluid and injecting the immunoglobulin composition.

Abstract: A connector device for a fluid system for medical purposes is disclosed that includes a main housing having a fluid flow chamber forming two channel portions leading in different directions towards two open attachments, wherein the attachments are provided for connection to a fluid line or a fluid reservoir, and with an attachment port which opens into the fluid flow chamber and which has a closure arrangement and which includes a Luer connecting portion. The fluid flow chamber has a dimensionally stable flow-guiding wall which is arranged between the two channel portions in the fluid flow chamber and protrudes freely with a front edge towards the attachment port in such a way that the closure arrangement, upon opening of the closure arrangement, interacts with the front edge of the flow-guiding wall in order to effect flow of fluid out of the attachment port into only one channel portion.

Abstract: An adapter configured to allow interconnection of a device input connector (DIC) having a first connector configuration and an consumable end connector (CEC) having a second connector configuration, the adapter including a first end having a first connector mateable with the DIC, a second end configured to receive at least part of the CEC, a locking mechanism configured to lock the CEC to the adapter, and a release mechanism configured to release the CEC from the adapter.

Abstract: A injection site information cap includes a housing, a cover portion, an engagement portion configured to couple to and cover an injection port of an injection site, and at least one information element on the cover portion that is positioned to be automatically sensed by at least one sensor of the injection site when the engagement portion is coupled to or is being coupled to the medication injection port. Related apparatus, systems, and techniques are also described.

Abstract: An example of a method of enabling medical fluid transfer between a source container and a destination container can comprise the steps of providing a closed-system fluid transfer module comprising a first closeable, resealable medical connector and a second closeable, resealable medical connector, a multidirectional fluid control valve with a driving interface configured to interface with an electromechanical driver of an electronic medical fluid transfer device, and an intermediate container or an intermediate pumping region; and instructing a user to couple the closed-system fluid transfer module to the electronic medical fluid transfer device.

Abstract: The disclosure describes a scheme for managing the operations of a flash memory. The scheme enables the flash memory to be used in a write-once mode to allow non-volatile storage of small amounts of data that must be written repeatedly. Among other things, the scheme eliminates the need to erase sectors of the flash memory, thus eliminating the high current consumption associated with erasures, while enabling preservation of relevant data in those sectors. In the context of an implantable medical device, this scheme is used to store data that is needed after a reset of the device, such as MRI-related data that is/are dynamically adjusted by firmware, or program code updates.

Abstract: A system for electrostimulation therapy includes two or more electrodes of different metals or metal alloys. The electrodes can be optionally provided on a flexible non-conducting substrate with a binder, thereby acting as a bandage or patch. Alternatively, the electrodes can be in the form of a needle, such as acupuncture needle, bracelets, armbands, wristbands, necklaces, or jewelry pieces. A method for electrostimulation therapy includes the steps of attaching a first electrode to a user or soil of a plant at a first location and attaching at least one additional electrode to the user or the plant at other locations for a predetermined period. The electrodes are not connected to a voltage or current source. Because at least two electrodes are of different metals, they cause an electrical current to flow via at least a portion of the user or the soil of the plant.

Abstract: An implantable medical lead may include a lead body, a substrate, and an elastic deflection component. The lead body includes a proximal end configured to couple to an implantable pulse generator, a distal end opposite the proximal end, and an electrical conductor extending through the lead body. The substrate is at the distal end and supports an array of electrodes. The elastic deflection component physically and electrically connects the electrical conductor and an electrode of the array of electrodes. The elastic deflection component is configured to compensate for at least one of tension forces or compression forces transferred from the electrical conductor to the electrode of the array of electrodes.

Abstract: An implantable electrode paddle is adapted to receive an electrical signal from a medical device and generate an electrical field to stimulate selected body tissue. The paddle includes a housing including walls that define an interior space and a plurality of windows formed through at least a first one of the walls for transmitting the electrical field to the body tissue, an electrode array including a plurality of electrode groups, each electrode group including at least two electrodes individually secured in a respective window and spaced between about 0.1 mm and about 10 mm apart, and a plurality of wires, each of the wires being coupled to a respective electrode and routed within the interior space to receive the electrical signal. A lead assembly and an implantable medical device can include the paddle.

Abstract: An implantable leadless cardiac pacing device and associated retrieval features. The implantable device includes a docking member extending from the proximal end of the housing of the implantable device including a covering surrounding at least a portion of the docking member configured to facilitate retrieval of the implantable leadless cardiac pacing device.

Abstract: A cardiac pacing system that includes an implantable pulse generator and electrical leads that include a lead body portion having a distal end and a proximal end, a connector configured to electrically connect the proximal end of the lead body to the pulse generator, and at least one electrode disposed at the distal end of the lead body for delivering electrical stimulation to a patient's heart, wherein the distal end of the lead body is configured to terminate within the mediastinum of the thoracic cavity of the patient, proximate to the heart.

Abstract: Systems and methods for treating gastroesophageal reflux disease (GERD) includes minimally invasively implanting a stimulating device in a patient's esophagus in the region proximate the lower esophageal sphincter (LES). The patient is provided with a questionnaire related to his disease via an online service. The questionnaire is accessed on a mobile device, such as a cell phone, or on a computer with network access. The data from the sensors and the answers from the questionnaire are analyzed together by a health care provider using the online service. The data and answers are used to program the stimulating device, via the mobile device or computer, to optimize treatment.

Abstract: Disclosed is a voltage monitoring circuit for use in detecting if a voltage supplied to current-generating circuit is sufficient to allow the current-generating circuit to produce a desired current. In one embodiment the circuit is designed for use in an implantable device that is configured to deliver therapeutic pulses to a patient. The voltage monitoring circuit is configured to produce a signal if a supplied voltage is insufficient to allow a current-generating circuit to deliver a requested current to a set of electrodes. In one embodiment, the voltage monitoring circuit detects a change in a difference between the voltage at a node in the current-generating circuit and the supplied voltage.

Abstract: The present disclosure relates to an electrical stimulation system, comprising, in accordance with one exemplary embodiment of the present invention, an analysis portion recognizing a brain activation pattern of a first user by analyzing a brainwave signal of the first user measured by a first electrical stimulation apparatus; and a stimulating portion applying an electrical stimulation to the brain of a second user on the basis of the information on the recognized brain activation pattern of the first user, wherein the first electrical stimulation apparatus includes a detecting portion detecting the second user's approach.

Abstract: Described is a system for inducing a desired behavioral effect using an electrical current stimulation. A brain monitoring subsystem includes monitoring electrodes for sensing brain activity, and a brain stimulation subsystem includes stimulating electrodes for applying an electrical current stimulation. Multi-scale distributed data is registered into a graphical representation. The system identifies a sub-graph in the graphical representation and maps the sub-graph onto concept features, generating a concept lattice which relates the concept features to a behavioral effect. Finally, an electrical current stimulation to be applied to produce the behavioral effect is determined.

Abstract: A method of operating an implantable neuromodulator coupled to an electrode array implanted adjacent tissue of a patient having a medical condition comprises conveying electrical modulation energy to tissue of the patient in accordance with a modulation parameter set, wherein conveying the electrical modulation energy to tissue of the patient in accordance with the modulation parameter set stimulates dorsal horn neuronal elements more than dorsal column neuronal elements.

Abstract: Temporary or sub-threshold electrical stimulation to promote recovery of a damaged or injured nerve. Methods include promoting neuroregeneration of a nerve iatrogenically injured during a medical procedure performed on a target site of a patient's body. Methods include placing an electrical lead in electrical communication with the injured or damaged nerve. Methods further include temporarily stimulating the nerve and/or applying sub-threshold stimulation to the nerve to promote neuroregeneration of the nerve. The nerve can be a peripheral nerve.

Abstract: A tissue stimulation system and computer software and method of monitoring a neurostimulation lead having a plurality of electrodes implanted within a patient (e.g., adjacent the spinal cord) is provided. Neurostimulation lead models are provided, each of which includes estimated electrical parameter data (e.g., electrical field potential data) corresponding to a predetermined position of the neurostimulation lead. Electrical energy is transmitted to or from the electrodes, and electrical parameter data (e.g., electrical field potential data) is measured in response to the transmitted electrical energy. The measured electrical parameter data is compared with the estimated electrical parameter data of each of the neurostimulation lead models, and a position of the neurostimulation lead is determined based on the comparison.

Abstract: An implantable device includes a lead, for example for neurostimulation of the vagus nerve. The lead includes a series of stimulation electrodes and a series of external electrodes for bioimpedance measurements on blood flow located in the same region, for example on the carotid artery. The device further includes means for separating into frequency bands the measured bioimpedance signal, the bands selected to reflect different respective activities such as vasomotor activity, hemodynamic activity, respiration, and cardiac rhythm activity.

Abstract: A patient-initiated automatic neural tissue control system and methods of providing patient-initiated automatic control of neural tissues are disclosed. The patient-initiated automatic neural tissue control system and methods allow for patient-defined internal initiation of motor control, by initiation of the controlling signals in the contralateral motor area the patient controls (e.g., previously damaged motor areas). The patient-initiated automatic neural tissue control system and methods involve brain signals that initiate from patient-defined motor actions from the contralateral motor area of the patient's brain which stimulates brain areas near the damaged brain areas. The brain areas stimulated near the damaged brain area include brain areas adjacent to the damaged brain area and brain areas below the damaged brain area.

Abstract: A system and method are provided to deliver interleaved stimulation to nerve tissue of interest. The system and method comprises an array of stimulation electrodes. The array is configured to be implanted proximate to nerve tissue of interest. An implantable medical device (IMD) is coupled to the array. The IMD includes memory storing a composite resultant pulse (CRP) sequence comprising first and second component sequences of first and second resultant pulse trains, respectively. One or more pulses from at least one of the first or second component sequences are temporally shifted relative to a corresponding target component sequence. The IMD further comprises a pulse generating circuit and switching circuit coupled to an output of the pulse generating circuit and the array. The switching circuit is configured to connect the pulse generating circuit to different combinations of the electrodes.

Abstract: A device is provided for stimulating neurons that includes an implantable stimulation unit that generates stimuli in multiple stimulation elements. The stimulation unit generates the stimuli to stimulate a neuron population in the brain and/or spinal cord of a patient using the stimulation elements. Moreover, the device includes a control unit that controls the stimulation unit to repeatedly generates sequences of the stimuli with the order of the stimulation elements in which stimuli are generated within a sequence being constant for 20 or more successively generated sequences before it is varied.