Abstract: Methods and reagents are disclosed for minimizing a false result in an assay measurement for determining a concentration of an analyte in a sample suspected of containing the analyte. The method comprises pretreating both an antibody and a sample to be subjected to a non-agglutination immunoassay. In the method the antibody and the sample are combined with a pretreatment agent selected from the group consisting of hydroxyphenyl-substituted C1-C5 carboxylic acids and metallic salts thereof and halogen-substituted C1-C5 carboxylic acids and metallic salts thereof in an amount effective to enhance the accuracy of the non-agglutination immunoassay.

Abstract: A field apparatus (also referred to as a “biosampler”) is configured to automatically capture multiple samples of an aqueous medium (for example, water from a lake) and process same to preserve unstable analytes in the field. In this way, a set of samples from the aqueous medium can, for example, be captured at multiple points in time, processed with a biopreservative to preserve unstable analytes (for example, RNA) and then later collected for further analysis. Alternatively, multiple samples of the aqueous medium can be collected and preserved at one moment.

Abstract: The present invention is a kit for the determination of a neurodegenerative disease wherein separately from each other the content of kynurenine and kynurenic acid in a body fluid is determined and the quotient of the content of kynurenine to the content of kynurenic acid is calculated.

Abstract: Provided is a substrate for a chromatography medium that is included in an immunochromatographic strip, in which the substrate is formed of a hydrophilic polyolefin microporous membrane; the substrate has a contact angle one second after dropwise addition of water of from 0 degrees to 60 degrees on at least one surface of the substrate; and the substrate has a capillary flow time of from 5 seconds/4 cm to 300 seconds/4 cm.

Abstract: The present invention relates to labelled silica-based nanoparticles with enhanced properties, to process for preparing them and to uses thereof.

Abstract: The present disclosure provides methods and compositions that find use in identifying presence of an advanced stage autoimmune liver disease (ALD) is a subject diagnosed as having ALD. Also provided here are methods and compositions that find use in monitoring effectiveness of treatment of an ALD patient receiving a treatment for the ALD. Also provided here are methods and compositions that find use in identifying subjects suffering from a relapse of ALD. The methods and compositions of the present disclosure also find use in facilitating treatment decisions for a subject having ALD.

Abstract: The application provides heat-treated Limulus amebocyte lysates useful for detecting ?-glucans.

Abstract: A novel serological target marker GP73 used for diagnosing and identifying a simple fatty liver and steatohepatitis in populations with fatty liver and a detection application method thereof. The serological target marker GP73 and the application thereof can replace golden standard liver puncture to identify and diagnose the simple fatty liver and steatohepatitis in populations with fatty liver, reduce the detection pain of a patient, and have an extremely high clinical application value in clinically identifying and diagnosing the simple fatty liver and steatohepatitis in the populations with fatty liver and assisting the treatment of the simple fatty liver and steatohepatitis.

Abstract: The present invention provides a method for identifying biomarkers and generating an output indicative of lung cancer. The method for identifying biomarkers comprises the steps of collecting a breath sample from subjects known to have nodules on a LDCT and subjects known to be free of nodules on the LDCT; analyzing the collected breath samples to determine all mass ions in each of the collected breath samples using at least one time-resolved separation technique and at least one mass-resolved separation technique; identifying a subset of the determined mass ions in a processor as the biomarkers for detecting lung cancer.

Abstract: [Problem] To provide a method for acquisition of data able to serve as an index for determining the likelihood that an ovarian endometriosis cyst is cancerous. [Solution] This data acquisition method for determining the likelihood that an ovarian endometriosis cyst is cancerous includes an iron concentration measurement step for measuring the iron concentration in the cystic fluid of the ovarian endometriosis cyst. This diagnostic device for diagnosing the likelihood that an ovarian endometriosis cyst is cancerous is provided, at a minimum, with an iron concentration measurement unit for measuring the iron concentration in the cystic fluid of the ovarian endometriosis cyst.

Abstract: The present invention provides a method of capturing circulating tumor cells (CTCs) from a subject without using a cancer biomarker. The method comprises contacting a test sample with a carbon nanotube (CNT) sponge. The test sample comprises cells from a small amount of peripheral blood from a subject after removal of plasma and lysis of erythrocytes. The cells in the test sample comprise CTCs from the subject. The CNT sponge is free of an agent specific for a cancer biomarker.

Abstract: Disclosed herein are methods of detecting at least one target biomolecule in at least one single cell comprising lysing the single cell or cells and performing a cell identification assay and target identification assay. Also disclosed herein are methods for preparing a sample for undergoing single cell analysis, wherein the single cell analysis comprises performing a cell identification assay and a target identification assay.

Abstract: Herein is reported a method for selecting an antibody with a systematic clearance in cynomolgus monkeys of less than 8 mL/kg/day comprising the steps of measuring the retention time of the antibody on performing an FcRn affinity chromatography with a positive linear pH gradient and on a heparin affinity chromatography with a positive linear conductivity/salt gradient, and selecting an antibody that has a relative retention time on the FcRn affinity chromatography column is less than 1.78 times the retention time difference between peaks 2 and 3 the retention time of preparation of an oxidized anti-Her3 antibody of SEQ ID NO: 03 and 04, and a relative retention time on the heparin affinity chromatography column is less than 0.87 times the retention time of an anti-pTau antibody of SEQ ID NO: 01 and 02.

Abstract: The present invention includes a method of detecting free and total NAC, NACA, or both in a biological sample and/or the effectiveness of a treatment with NAC, NACA, or diNACA comprising: adding 2-chloro-1-methylpyridinium iodide (CMPI) to a biological sample suspected of having NAC or NACA to convert free thiols into stable thioethers; precipitating the protein in the sample; extracting the stable thioethers and separating into a first and a second extract; detecting the thioether derivatives from the first extract with LC-MS/MS; reducing from the second extract free thiols by adding tris(2-carboxyethyl)phosphine (TCEP) followed by converting to stable thioethers with CMPI; detecting the disulfides reduced to free thioether derivatives from the second extract with LC-MS/MS; and calculating from the LC-MS/MS and TCEP of the first and second extracts a free and a total sample NAC or NACA.

Abstract: The present description provides methods, assays and reagents useful for sequencing proteins. Sequencing proteins in a broad sense involves observing the plausible identity and order of amino acids, which is useful for sequencing single polypeptide molecules or multiple molecules of a single polypeptide. In one aspect, the methods are useful for sequencing multiple polypeptides. The methods and reagents described herein can be useful for high resolution interrogation of the proteome and enabling ultrasensitive diagnostics critical for early detection of diseases.

Abstract: Provided herein are methods, kits, and assays for identifying and quantifying a mitochondrial protein in a sample using mass spectrometry. Also provided herein are methods, kits, and assays for determining a mitochondrial protein biomarker signature for a subject using mass spectrometry.

Abstract: The present disclosure relates to a method for using chemical tags which have two or more sites for ionization to improve quantification and identification of components of interest from a complex mixture. This method relies on first selectively reacting one or more component in a sample with a chemical tag having two or more sites for ionization, followed by separation of components based on charge status, and finally characterization of each component to identify the same. Additionally disclosed are compounds useful as chemical tags in the disclosed methods.

Abstract: Methods of using biomarkers in determining the efficacy of a treatment for an organic acidemia in a subject are disclosed herein. Methods of using biomarkers in determining the efficacy of a liver-directed treatment for an organic acidemia in a subject are likewise disclosed herein.

Abstract: Use of prostacyclin or an analogue thereof for treatment of a new medical indication in acute critically ill patients, in particular acute critically ill patients with systemic endothelial damage, a biomarker for identifying individuals that have a new medical indication, and a method for identifying a new medical indication.

Abstract: The present invention relates to the use of a derivative of melatonin in an assay, wherein said derivative is a conjugate at position 3 of melatonin's indole ring and wherein said conjugate comprises a linker of at least 2 carbon atoms, with the proviso that the conjugate does not comprise a polypeptide or protein antigen. The derivative preferably comprises 3-(2-ethylamidoglutaric acid)-5-methoxyindole (GUS) and is coupled to a carrier such as dextran. The invention further relates to a method for detecting and/or quantifying melatonin in a sample using a compound comprising said derivative of melatonin, a corresponding immunobiological assay and a kit of parts for detecting and/or quantifying melatonin based on the melatonin derivative.

Abstract: Methods are described for determining the amount of metabolites of leflunomide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying teriflunomide in a sample.

Abstract: Some embodiments of the disclosure provide a time-resolved fluorescent immunochromato-graphic test strip for detecting vancomycin as well as a preparation method and application thereof. In some embodiments, the test strip includes a bottom plate and a sample absorption pad. A fluorescent microsphere pad, a nitrocellulose membrane coated with a vancomycin-carrier protein conjugate, and an absorbent pad are sequentially overlapped and pasted on the bottom plate. The fluorescent microsphere pad is sprayed with a fluorescent microsphere-labeled vancomycin monoclonal antibody, and the vancomycin monoclonal antibody is prepared by using a vancomycin-bovine serum albumin conjugate as an immunogen.

Abstract: Disclosed herein are methods, devices, and systems for loading and retrieval of particles. In some embodiments, a loading station comprise a tray configured to receive a microwell array, a first magnet, a second magnet, and an actuation mechanism configured to cause movement of at least one of the first magnet and the second magnet.

Abstract: A power off delay system and method is configured to delay termination of electrical power to a digital pathology device in a power off condition. If the apparatus includes a UPS, the power off delay system and method delays termination of electrical power when a power switch is turned off and when a catastrophic power failure occurs. During the delay of the termination of electrical power, the digital pathology device is configured to control the scanning stage system and the glass slide conveyor system and the slide rack conveyor system to place each of these systems into a known state and position all glass slides into a known position prior to the termination of electrical power to the digital pathology device. This allows the digital pathology device to resume normal operation upon power up.

Abstract: There is provided an automatic analysis device that can appropriately sort and discard expendable items. The automatic analysis device includes a common transport mechanism that transports a plurality of types of expendable items by common mechanism, a plurality of transport paths that is provided separately from the common transport mechanism, a type determination portion that determines the type of expendable item being transported by the common transport mechanism. The automatic analysis device controls to select one of a plurality of transport paths according to a determination result of the type determination portion and to transport the expendable items transported from the common transport mechanism via the selected transport path.

Abstract: The dispensing unit includes a disc, a cartridge, and a dispensing holder. The disc has a disc shape and includes a track region provided with recesses and projections alternately arranged in a radial direction. The cartridge includes a penetration hole, and a well is formed by the penetration hole and the track region in a state in which the cartridge is attached to the disc. The dispensing holder includes a holding part to be inserted into the penetration hole, and a guide hole penetrating the holding part. The guide hole has a truncated cone shape in which a first opening diameter on the holding part side is smaller than a second opening diameter on a side opposite to the holding part, and a center line of the guide hole is located on a line passing through the center of the disc and the center of the well.

Abstract: An automatic analysis apparatus and an operating method therefor. A temporary storage portion is introduced, a multi-component test project may be divided into new one-step test processes, or a multi-step test process may be divided into new one-step test processes, and test sequences and processes may be re-entered, so that each mechanism, unit and control time sequence may be designed according to one-step test processes in a standard and orderly manner, so as to solve the problem that multi-component test projects and multi-step test processes disturb normal processes, thereby effectively increasing the test speed and the test throughput of the whole machine.

Abstract: Provided is a connection module with a high degree of freedom for an automatic analyzer which does not depend on a device as a discharge destination. For this purpose, a module to be connected to an automatic analyzer with a rack rotor mechanism includes: a rack discharge mechanism for moving a rack from the rack rotor mechanism to a rotation holder; a rack rotating mechanism for rotating the rack moved to the rotation holder; a conveyor mechanism for transporting the rack from the rack rotating mechanism to a discharge port; and a feeder mechanism for pushing the rack out of the rotation holder to the conveyor mechanism, in which the rack rotating mechanism rotates the rotation holder from a direction parallel to the rack discharge mechanism to a direction parallel to the feeder mechanism and the conveyor mechanism in the selected rotation direction.

Abstract: A feature amount extraction unit outputs, as a data series, a feature amount of time-series data of an oscillation frequency of an AC signal of an oscillation circuit until a certain time elapses from when a dispensing probe starts to be lowered. Then, a bubble contact determination processing unit determines whether a liquid level has been normally detected based on a correlation between a waveform of the data series of the feature amount and an abnormal waveform model. Further, based on a determination result, a second controller determines a deviation between a tip portion of the dispensing probe and the liquid level in a container and a factor of the deviation.

Abstract: An open fluid droplet ejection cartridge containing one or more fluids to be dispensed by digital fluid dispense system and a method for digitally dispensing fluids. The open fluid droplet ejection cartridge includes a cover having one or more openings therein, fluid funnels pending from each of the one or more openings in the cover, a chamber separator attached to the fluid funnels for directing fluid to one or more fluid chambers, a fluid overflow chamber for fluid overflow from the one or more fluid chambers, fluid vias associated with each of the one or more fluid chambers, and a plurality of fluid ejection devices adjacent to the fluid vias on a single semiconductor substrate in fluid flow communication with the fluid vias.

Abstract: A system utilizes a flow cell for holding an analyte of interest for examination, such as a genetic material to be imaged for sequencing. Liquids, such as reagents and washing fluids are introduced into the flow cell during operations. A degasser removes gasses from at least some of the liquids before introduction into the flow cell. The liquids may be resident in the flow cell during detection operations, such as imaging. At least one fluid may be moved bidirectionally into and from the flow cell, such as for reuse. Another fluid may be moved unidirectionally through the flow cell to remove bubbles that may be present in the system.

Abstract: A method and apparatus for resistive short circuit immunity for wheel speed sensor interface on braking system. In one embodiment the apparatus includes a first circuit for transmitting a first current to a wheel speed sensor, and a second circuit for receiving a second current from the wheel speed sensor. Another circuit is coupled to the first and second circuits and configured to detect and respond to a near zero resistive short between the wheel speed sensor and ground. In this embodiment the circuit is configured to detect the near zero resistive short based on a direct or indirect comparison between magnitudes of the first and second currents to a first predetermined value, and based on a direct or indirect comparison between magnitudes of the first and second currents to a second predetermined value.

Abstract: The Coaxial Angular Velocity Sensor System is an electronic sensor, which processes and supplies the output signal of the inertial angular velocity with high accuracy and great reliability. The device consists of the main components: angular velocity sensor, analog-digital converter, microcontroller, temperature sensor, power source, mechanical anti-noise-proof chassis. The device's microprocessor comes with a signal processing algorithm that helps increase the accuracy of the device's output. Because of its compact size, high precision, and low cost, the device is used in high precision devices such as UAV cameras, or in life applications such as self-balancing vehicles.

Abstract: The invention generally relates to a wind indicating device used for determining wind detection. The device comprises two chambers which can contain two different materials for determining the direction the wind is traveling and/or swirling. This is beneficial to hunters in pursuit of game animals.

Abstract: Techniques provided herein are directed toward addressing these and other issues by providing robust means for initializing an accelerometer that can take place even while a vehicle is in motion. Specifically, linear acceleration and velocity data can be estimated from wheel speeds, and angular velocity can be estimated with a gyroscope. The vehicle's acceleration can then be computed from these estimates, and subtracted from a total acceleration measured by the accelerometer to determine gravitational acceleration, which can then be accounted for in subsequent measurements taken by the accelerometer. A vehicle velocity may also be determined based on the vehicle's estimated angular velocity and linear velocity. Embodiments may also employ techniques for translating measurements taken in one coordinate frame to another coordinate frame for estimate determination and/or outlier compensation.

Abstract: System and Methods may be provided for performing chemical spectroscopy on samples from the scale of nanometers with surface sensitivity even on very thick sample. In the method, a signal indicative of infrared absorption of the surface layer is constructed by illuminating the surface layer with a beam of infrared radiation and measuring a probe response comprising at least one of a resonance frequency shift and a phase shift of a resonance of a probe in response to infrared radiation absorbed by the surface layer.

Abstract: Methods, systems, and apparatus are presented for performing network probing. A user equipment device (UE) may store a record associating traditional service set identifiers (SSIDs) with corresponding Short SSIDs. According to some embodiments, the UE may receive a message including a Short SSID, and determine whether a corresponding full SSID is known to the UE. Based on the determination, a probe request may be generated, addressed to either the Short SSID or the full SSID. After transmitting the probe request, the UE may receive a probe response, which may include a full SSID corresponding to the Short SSID. The UE may store a record associating the full SSID with the Short SSID, if applicable. According to some embodiments, a UE may receive a plurality of messages including respective SSIDs, and may generate a single probe request addressed to the SSIDs. The UE may receive a plurality of probe responses.

Abstract: Devices, systems, and methods that can facilitate in situ probing of a discrete time circuit components are provided. According to an embodiment, a device can comprise a hold circuit that can generate a sampled signal at a holding stage. The device can further comprise an in situ probe device that can be coupled to the hold circuit that can measure one or more operating voltage values at the holding stage based on the sampled signal.

Abstract: A system includes a control circuit and a computer. The control circuit includes a control circuit configured to receive data from at least one solar panel, convert the received data according to a communication protocol, and forward the converted data via the communication protocol. The computer includes software that, when executed by the computer, causes the computer to receive, via the communication protocol, the converted data, detect, based on the received converted data, a problem in the at least one solar panel, and output, to a display and based on the detected problem, a status of the at least one solar panel corresponding to a time at which the data was collected.

Abstract: A method for the dynamic configuration of a test chamber for wireless communications is provided. The method includes identifying a current test project to be performed on a test device. The test device is disposed within a test chamber for evaluating one or more interactions of the test device with a wireless communication network. The method also includes determining a test configuration of a wireless connection interface of the test chamber based on the identified current test project and then sending a control signal to the wireless connection interface to set the wireless connection interface to the test configuration. In operation, the test configuration of the wireless connection interface controls which of a plurality of wireless signals of the wireless communication network are emitted within an interior the test chamber.

Abstract: A system for testing wireless communication equipment which includes a beamforming antenna, the system comprising: a probe for coupling an antenna element of the beamforming antenna of the wireless communication equipment to be tested to a test and measurement unit; and a lid configured to cover the beamforming antenna, wherein the lid is provided with a port for receiving the probe, such that the probe couples to the antenna element.

Abstract: Methods and systems are provided in which an electric field above a threshold strength may be detected at one or more wearable articles and in which at least a haptic actuator of the one or more wearable articles is energized in response so as to warn the wearer and thereby effectively prevent electrical injury even if other modes of notification are unavailable.

Abstract: A device including at least two transfomers, wherein: each winding of a transformer is electrically in series with a winding of another transformer, and the transformers have a transformation ratio different from one.

Abstract: An electronic device and method related to measurement of an electromagnetic (EM) signal emitted from an external electronic device. The electronic device including a processor, a memory, and an EM sensor.

Abstract: An earth leakage circuit breaker and a method of controlling the same are disclosed. An earth leakage circuit breaker according to the present disclosure can detect a type of leakage current and output the type of the leakage current in various forms such that a user can recognize the type of the leakage current. Therefore, the user can easily recognize whether or not the leakage current has occurred and the type of the leakage current. This may facilitate the user to recognize the cause of the leakage and take an effective measure for preventing an accident.

Abstract: The electromagnetic noise of a semiconductor device is conveniently evaluated, and the electromagnetic noise of an apparatus equipped with the semiconductor device is estimated. An evaluation method is provided which includes causing one of a first device and a second device of a semiconductor device to perform a switching operation, the semiconductor device comprising the first device and second device connected in series and a third device and a fourth device connected to each other in series and connected parallel to a series circuit of the first device and second device; measuring voltage variation occurring between the third device and the fourth device during the switching operation; and outputting an evaluation benchmark for electromagnetic noise of the semiconductor device, based on the voltage variation.

Abstract: A measurement system and method for over the air multiple antennas measurements are provided. The measurement system comprises, inside an anechoic chamber, a device under test, several measurement antennas, several mirrors and at least one shaped reflector. The measurement antennas are placed pointing at the shaped reflector. Each of the mirrors is placed along fields reflected by the shaped reflector. The mirrors reflect fields that form different angles of arrival at the device under test.

Abstract: The present disclosure relates to a circuit testing system, including a control circuit and an I/O interface circuit. The control circuit is electrically connected to a test machine, and is configured to receive a scan control signal. The I/O interface circuit is electrically connected to the control circuit, the test machine, the scan chain circuit and a circuit under test. When the scan control signal is at a first level, the control circuit is configured to control the I/O interface circuit to propagate a scan test signal sended from the test machine to the scan chain circuit. When the scan control signal is at a second level, the control circuit is configured to control the I/O interface circuit to propagate a response signal generated by the circuit under test to the test machine.

Abstract: The present disclosure relates to a circuit testing system, including a control circuit and an interface circuit. The control circuit is electrically connected to a test machine, and configured to receive a scan control signal. The I/O interface circuit is electrically connected to the control circuit, the test machine, the scan chain circuit and a circuit under test. When the scan control signal is at a first level, the control circuit is configured to control the I/O interface circuit to conduct the scan chain circuit to the test machine. When the scan control signal is at a second level, the control circuit is configured to control the I/O interface circuit to conduct the circuit under test to the test machine so as to propagate a response signal generated by the circuit under test to the test machine.

Abstract: The disclosure describes a novel method and apparatus for improving the operation of a TAP architecture in a device through the use of Command signal inputs to the TAP architecture. In response to a Command signal input, the TAP architecture can perform streamlined and uninterrupted Update, Capture and Shift operation cycles to a target circuit in the device or streamlined and uninterrupted capture and shift operation cycles to a target circuit in the device. The Command signals can be input to the TAP architecture via the devices dedicated TMS or TDI inputs or via a separate CMD input to the device.