Abstract: A test device for a detector for detecting gas or a gas/particle mixture, includes a joining means for joining the test device to the detector; a container configured so as to receive a gas or a test gas/particle mixture; a diffusion means associated with the container and designed to diffuse the gas or the test gas/particle mixture in the detector; an energy source; and a radio apparatus able to manage local radio communication in order to remotely trigger the diffusion of the gas or of the test gas/particle mixture in the diffusion means from a control means. A test system comprising at least one test device, at least one radio gateway, a control network comprising a control unit able to remotely control the test device and at least one communication link between the control unit and the radio gateway, said gateway being able to connect the radio apparatus and the control network.

Abstract: A technique for monitoring and collecting environmental data is provided that supports acquisition and analysis of quality measurements of pollutants by sensors based on different technologies in an integrated manner. The system includes a primary substrate having a plurality of sensor modules, each sensor module configured to couple to a sensor, and a manifold having a plurality of flow hoods, each flow hood disposed on a top surface of a sensor and connected to another flow hood or component in the manifold. In some cases, the sensor modules are gas sensor modules, and the sensor is a gas sensor. The manifold thus provides a closed system through which a fluid sample can flow across a series of gas sensors in an actively controlled manner that enables independent flow control over each individual gas sensor while limiting exposure of the fluid sample to potential sources of contamination.

Abstract: A mobile sensory platform includes a propulsion system configured to move the platform within a growing area, a vertically-extending support, and sensors in or on the support. Different sensors are positioned at different heights along the support. The sensors are configured to capture data associated with plants in the growing area. The platform also includes a communication interface configured to support two-way wireless communication, a power supply, and a control system configured to control movement of the platform and operation of the sensors. The sensors include microclimate sensors configured to sense microclimates around individual ones of the plants and stereo imaging sensors configured to capture images of the plants. The sensors are configured to non-invasively capture multi-dimensional data points for the individual ones of the plants. At least some of the multi-dimensional data points are associated with a 3D structure of a canopy of the individual ones of the plants.

Abstract: A TOC analyzer for determining a carbon content of a sample includes: a processing unit for removing carbon dioxide gas from the carrier gas before the oxidation of the sample, wherein the processing unit has a binder for binding the carbon dioxide gas from the carrier gas, wherein a defined water content is provided within the binder, wherein the processing unit is configured for moistening the binder by means of water vapor contained in the carrier gas; a condensation unit for condensing the water vapor resulting from the vaporization and/or oxidation of the sample to form a condensate, wherein the condensation unit has an outlet for the condensate toward a moistening unit; and the moistening unit for moistening the carrier gas by means of the condensate. A method for moistening a binder using such a TOC analyzer is further disclosed.

Abstract: A method for determining a hydrocarbon concentration from drilling fluid includes pumping the drilling fluid into a wellbore and circulating a sample of the drilling fluid uphole from the wellbore so that ?13C isotopic signatures can be determined for one or more hydrocarbon components and for methane in the sample where the methane includes natural methane originating from the earth formation and artificially-produced methane caused by drill bit metamorphism (DBM). A processor is adapted to determine the concentration of the natural methane in the sample based in part on the ?13C isotopic signatures which may be performed during the drilling of the wellbore.

Abstract: A method of analyzing dissolved gas in an oil-filled transformer includes determining a centroid of a polygon that represents a plurality of dissolved gas concentrations. A fault region in which the centroid of the polygon is located is determined, where the plurality of fault regions are defined in a composite fault region map that is a composite of a Duval Pentagons 1 and 2. The method classifies a fault experienced by the transformer based on the determined fault region within the composite fault region map. The classification is done by a machine learning classification technique. Further embodiments classify faults based on dissolved gas levels without determining a centroid of a polygon representing the dissolved gas levels. Related systems are also disclosed.

Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.

Abstract: The invention relates to the identification of OR5A2 as an Olfactory Receptor that binds natural musk and synthetic musks. The invention encompasses the use of the interaction of OR5A2 polypeptides and nitromusk, polycyclic musk, macrocyclic musk and alicyclic musks as the basis of screening assays for agents that specifically modulate the activity of the OR of the invention.

Abstract: A method for optimal selection of cytotoxic agents for organ or region specific therapy that includes extracorporeal filtration of the cytotoxic agent from blood drained from the organ or region being treated and return of the filtered blood to a mammal is disclosed.

Abstract: The present invention provides methods of determining cell sensitivity to a therapeutic agent.

Abstract: The present invention relates provides methods of predicting cell sensitivity to a test agent. In some embodiments, the cells are cultured in a culture medium having serum.

Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.

Abstract: Embodiments herein described provide methods for determining phenotypic parameters of cell populations and expressing them in terms of tensors that can be compared with one another. Embodiments provide methods for determining phenotypic parameters of cell populations in response to an agent. Embodiments provide methods for comparing effects of an agent on phenotypic parameters to effects of reference standards whose in vivo effects are known. Embodiments provide methods for predicting the effect of an agent by the comparison with the known effects of reference standards. Embodiments provide methods for classifying agents by their effects on phenotypic parameters. Embodiments provide software and computer systems for calculating multiparametric tensors, compressing their complexity and comparing them after compression.

Abstract: An image processing device includes a determination unit configured to determine a type of autophagy induced in a cell, based on information indicative of autophagic activity in the cell present in a cell image in which the cell is image captured and based on information indicative of congestion of molecules in the cell present in the cell image.

Abstract: A colorimetric sensor for detecting bacteria and/or viruses includes one or more layers having a photonic crystal structure, a functional layer comprising a nanomaterial capable of generating bacteria- and/or viruses-bioresponsive surface plasmon overlapping the one or more layers having the photonic crystal structure. The bacteria- and/or viruses-bioresponsive nanomaterial of the functional layer is doped with proteinic substances or antibodies acting as virus receptors, or the colorimetric sensor comprises a receptor layer comprising proteinic substances or antibodies acting as virus receptors. The functional layer and receptor layer overlap each other. Alternatively, or in addition to, the colorimetric sensor comprises a plasmonic nanostructured layer comprising nanostructures such to generate plasmonic colors, overlapping the one or more layers having the photonic crystal structure.

Abstract: Devices and methods are provided for the detection of CSF in a biological sample.

Abstract: The present invention relates to latex particles for measurement reagents, said latex particles having a coefficient of variation in particle diameters of 10% or less and an average particle diameter of 250 to 1000 nm. Each of the latex particles contains 20% by weight or more of a compound having a refractive index of 1.60 or more. The depth of a supernatant is 5 mm or less when a liquid dispersion having a solid matter concentration of 1% by weight, which is prepared by dispersing the latex particles in ultrapure water, is placed in a tubular 10-ml measuring cylinder having a body inner diameter of 10.8 mm and is then allowed to leave for 10 days. According to the particles, a measurement of a measurement sample can be performed at a high sensitivity even when the concentration of a substance to be tested in the measurement sample is low.

Abstract: The invention relates generally to compositions and methods for detecting protease activity in a subject or a biological sample using activatable antibodies, and the use of these compositions and methods in a variety of diagnostic indications.

Abstract: The present disclosure provides high-performance immunoreagents for use in a variety of immunologic assays and other related techniques. The immunoreagents comprise a primary antibody and a bridging antigen, wherein the bridging antigen is recognized by a detectable secondary antibody with high affinity. Also provided are compositions comprising panels of immunoreagents specific for multiple different target antigens and compositions comprising pairs of primary immunoreagents and their complementary detectable secondary antibodies. The paired primary immunoreagents and secondary antibodies are useful in a variety of immunologic assays, particularly in highly multiplexed assays, where the structure of the bridging antigen is varied in tandem with variation in the detectable secondary antibody, such that a multiplicity of immunoreagents are provided that are capable of simultaneously detecting a multiplicity of target antigens in a single assay.

Abstract: A pancreatic cancer detection method is provided, including: (a) bringing extracellular vesicles, which are in a body fluid sample derived from a subject into contact with one or more kinds of lectins; (b) measuring an amount of the extracellular vesicles bound to the one or more kinds of lectins after (a); and (c) evaluating the presence of pancreatic cancer in the subject based on the amount of the extracellular vesicles measured in (b). In addition, a pancreatic cancer detection kit is provided, including: a solid-phase carrier on which one or more kinds of lectins are immobilized; and an antibody specifically binding to a pan-extracellular vesicle membrane protein or an antigen-binding fragment thereof.

Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.

Abstract: This invention provides a method for detecting an analyte in a sample, including a step of contacting said analyte with a nanoparticle to facilitate binding thereto, wherein the nanoparticle comprises: (i) a core; (ii) pores extending radially from said core and being defined by spaces between an array of dendritic spikes radiating outwardly from a surface of the core, wherein the pores have an average pore size of between about 10 nm and about 20 nm; (iii) a binding agent for binding the analyte; and (iv) a detection agent immobilized within said pores; to thereby detect said analyte. This invention also provides kits, compositions and products comprising said nanoparticle.

Abstract: The present disclosure relates to methods of identifying components present in intact lipoprotein particles. Methods provided include single particle mass spectrometry, such as charge detection mass spectrometry (CDMS). Distinct subtypes and subpopulations that exist within lipoprotein density classes are determined based on simultaneously measured m/z and charge of ionized lipoprotein particles.

Abstract: The present disclosure provides methods for classifying a cell as abnormal based on HD5 protein detection as well as methods for predicting prognosis of a subject with Crohn's disease based on HD5 protein detection.

Abstract: The present invention provides novel methods of identifying, monitoring or determining the risk of developing a protein misfolding neurodegenerative disorder in a subject, particularly an alpha synucleinopathy (including Parkinson's disease and dementia with Lewy bodies) using extracellular vesicle samples. Corresponding methods for selecting a treatment and assaying for the presence of a pathological prion-like protein (or one or more ceramide species) in an extracellular vesicle sample are also provided.

Abstract: Disclosed is a method of producing a test strip for detecting a calcium level in a body fluid test sample obtained from a biological subject such as a human or animal. Also disclosed is a test strip that is useful for determining the concentration of calcium in a human or animal body fluid test sample based on a colorimetric change, and thus provides early detection of osteoporosis by monitoring the calcium excretion rate in an easy and inexpensive manner.

Abstract: A method for determining a narcotic in a mixture comprising at least one interferant. The method comprises: (a) determining a voltage at which, in absence of the interferant, a voltammetric signal of the narcotic can be detected; (b) contacting an electrode with the mixture comprising the at least one interferant and potentially comprising the narcotic; (c) applying a pretreatment potential to the electrode for a duration of at least 5 seconds, the pretreatment potential measuring between ?0.4 V and ?2 V versus Ag/AgCl; (d) measuring a voltammetric response of the mixture, the measurement comprising at least the determined voltage; and (e) determining whether the narcotic is present in the mixture by analyzing whether the voltammetric signal of the narcotic, resolved from a voltammetric signal of the interferant, can be detected in the measured voltammetric response.

Abstract: Compounds and methods for use in detecting gabapentin in a sample suspected of containing gabapentin are disclosed. Gabapentin derivatives are used to produce gabapentin conjugates. A gabapentin-immunogenic carrier conjugate may be used as an immunogen for the preparation of an anti-gabapentin antibody. A gabapentin-detectable label may be used in a signal producing system in gabapentin assays.

Abstract: The methods and systems may include LC-MS/MS. For example the method may include obtaining MS/MS data for a predetermined MS/MS transition for THC and/or at least one THC metabolite and CBD and/or at least one CBD metabolite, and determining a ratio of the amount of the CBD and/or at least one CBD metabolite to the amount of the THC and/or at least one THC metabolite for the biological sample. In certain embodiments, the methods and/or systems are used to distinguish CBD from THC use in a subject.

Abstract: Embodiments of the present disclosure generally pertain to systems and methods for performing amplicon rescue multiplex polymerase chain reaction (arm-PCR). In one embodiment, the system comprises a processor and a reader coupled to a control element. The control element is configured to control the operation of the processor and the reader based on a variety of settings. The processor is configured to receive a self-contained cassette for performing PCR amplification of DNA and/or RNA obtained from an organic specimen. The processor engages with the cassette and manipulates reagents within the cassette in order to amplify and detect the DNA from the specimen. The processor also causes the cassette to deposit the DNA on a microarray within the cassette. The reader is configured to receive the cassette after it has been processed by the processor and to capture an image of the microarray for transmission to the control element as test data.

Abstract: Systems and methods for calibrating laboratory instruments. In an example, a laboratory instrument for testing patient specimens includes a testing apparatus configured to receive a cassette that includes a patient specimen or a quality control specimen. In response to determining that a quality control specimen is present, the instrument obtains a first measurement of a parameter. If the first parameter is outside an expected tolerance, the instrument ceases performing tests on all specimens, the instrument re-tests the quality control specimen to obtain a second measurement of the parameter. If the second measurement is within the expected tolerance, instrument resumes processing of the cassette. If the second measurement is outside the expected tolerance, the instrument indicates that recalibration or service is required.

Abstract: The conveying system includes a support guide element defining a guide track, the support guide element being configured to receive a containers support and guide said containers support in translation along the guide track; and a self-propelled conveying carriage displaceable along a conveying track extending along the support guide element, the self-propelled conveying carriage comprising a drive element movably mounted between at least one drive position in which the drive element is configured to transmit a drive movement to the containers support so received on the support guide element, and a release position in which the drive element is configured to release the containers support, the self-propelled conveying carriage being configured to displace the containers support in translation along the guide track when the drive element is in the drive position and the self-propelled conveying carriage is displaced along the conveying track.

Abstract: Aspects of the present disclosure relate to a method and/or a device for carrying out chemical, biochemical and/or immunochemical analyses of liquid samples, which are present in a sample store of an automatic analyzer, with the aid of liquid reagents which are present in at least one reagent store of the analyzer, with cuvettes for receiving the liquid samples and reagents, wherein a plurality of cuvettes is arranged as at least one stationary, linear cuvette array in the analyzer. The analyzer has movable and stationary automated components, wherein at least two automated components are designed so as to be movable in the x-direction independently of one another along or parallel to the line of movement defined by the linear cuvette array and each have access to different cuvettes or groups of cuvettes in a freely selectable sequence.

Abstract: A method and apparatus for measurement of density of a photosensitive printing plate (130) having a mask (132) embodying image information corresponding to an image to be printed. A density measurement system includes a first radiation source (112) spaced apart from and adjacent the plate and configured to emit radiation having a first wavelength or range of wavelengths toward the plate. A densitometer (110) spaced apart from and adjacent the plate in a fixed relationship relative to the first radiation source receives and measures an amount of the first radiation transmitted through or reflected by the plate and the mask during relative movement between the plate and the density measurement system. The densitometer readings are processed to provide an output correlating to quality of the mask. The density measurement system may be coupled to an exposure system (120,122,124) for curing the plate.

Abstract: A gas densimeter for monitoring a pressure or density of a gas in a gas chamber with a housing having a first housing chamber and a measuring chamber, a first coupling, via which the measuring chamber can be connected to the gas chamber, at least one reference bellows, which is connected directly or indirectly in particular to a transmission element, and at least one transmitting and/or monitoring unit, which is or can be operatively connected directly or indirectly to the transmission element. In this regard, the measuring chamber has a gas-permeable connection to the gas chamber via the first coupling and the reference bellows forms a reference chamber filled with a constant amount of a reference gas. A surface section covering the reference chamber is provided or reachable at least partially within the first housing chamber or measuring chamber as a measuring surface for the gas from the gas chamber.

Abstract: An optomechanical inertial reference mirror combines an optomechanical resonator with a reflector that serves as an inertial reference for an atom interferometer. The optomechanical resonator is optically monitored to obtain a first inertial measurement of the reflector that features high bandwidth and high dynamic range. The atom interferometer generates a second inertial measurement of the reflector that features high accuracy and stability. The second inertial measurement corrects for drift of the first inertial measurement, thereby resulting in a single inertial measurement of the reflector having high bandwidth, high dynamic range, excellent long-term stability, and high accuracy. The reflector may be bonded to the resonator, or formed directly onto a test mass of the resonator. With a volume of less than one cubic centimeter, the optomechanical inertial reference mirror is particularly advantageous for portable atomic-based sensors and systems.

Abstract: An accelerometer for measuring acceleration in the direction of a z-axis which is perpendicular to an xy-plane, where a first proof mass is suspended from a first side anchor point with a first suspension structure which allows the first proof mass to undergo rotation about a first rotation axis. A second proof mass is suspended from a second side anchor point with a second suspension structure. The second suspension structure allows the second proof mass to undergo rotation about a second rotation axis. The torsion elements in the first and second suspension structure lie further away from the center of the accelerometer than the corresponding side anchor points from which the masses are suspended.

Abstract: According to one aspect of the present disclosure, a device and technique for impact detection includes a housing, switch circuitry having an omega-shaped switch element, and a mass member movable within the housing from a first position to a second position in response to receipt by the housing of an acceleration event. Movement of the mass member to the second position causes the mass member to move the switch element to change a state of a circuit condition of the switch circuitry, and the change of the state of the switch circuitry indicates receipt of the acceleration event.

Abstract: A MEMS device includes: a substrate as a base including a support portion and a detection electrode as a fixed electrode; a movable body supported to the support portion with a major surface of the movable body facing the fixed electrode; and an abutment portion facing at least a portion of an outer edge of the movable body and restricting rotational displacement in an in-plane direction of the major surface. The abutment portion includes an abutment surface including an abutment position at which the movable body abuts against the abutment portion due to the rotational displacement of the movable body, and a hollow portion provided opposing the abutment surface.

Abstract: An air gap of a rotation speed sensor is increased. A rotation speed sensor according to one embodiment includes: a sensor component having magnetic sensing elements; and a magnetic plate that is arranged between the sensor component and a magnet and that is made of a magnetic material. In a first direction that is a direction in which the sensor component, the magnetic plate and the magnet are arranged, the magnetic plate includes an opening that is formed at a position overlapping center of a line connecting respective centers of the magnetic sensing elements.

Abstract: The invention relates to a method and a device for identifying and locating cyclic momentary insulation faults in an ungrounded power supply system, the method comprising the steps: detecting a fault current caused by the momentary insulation fault as a differential current in the branch circuit to be monitored and displaying the temporal progression of the differential current via a differential current signal by means of a differential current sensor; providing a processing signal which temporally describes a process sequence of a process taking place in the consumer; correlating the differential current signal with the processing signal in a computing unit in order to yield a correlation signal as a measure for a temporal match between the differential current signal and the processing signal; signaling the momentary insulation fault via the computing unit by means of a signaling signal if the correlation signal shows the temporal match.

Abstract: A fuse monitoring device for monitoring a fuse supported by a fuse block, the fuse monitoring device including a housing. The housing includes a holder attachment mechanism configured to connect the fuse monitoring device to a fuse block. The housing also includes a mounting attachment mechanism configured to connect the fuse monitoring device to a mounting structure and at least one sensor configured to be operably connected to a fuse and configured to measure fuse data associated with the fuse. The monitoring device further includes at least one processor communicatively coupled to the at least one sensor.

Abstract: Presented embodiments facilitate efficient and effective flexible implementation of different types of testing procedures in a test system. In one embodiment, a test system configuration adapter includes a tester side socket, a break out pin, and a device under test (DUT) side slot. The tester side socket is configured to couple with a test equipment socket. The break out pin is configured to couple with the supplemental equipment. The DUT side slot is configured to couple with the tester side socket, the break out pin, and a DUT. The test system configuration adapter is configured to enable communication between test equipment coupled to the test equipment socket and supplemental equipment coupled to the breakout pin while the DUT remains coupled to the DUT side slot. The breakout pin and tester side socket can be selectively coupled to the DUT side slot.

Abstract: Embodiments are directed to probe structures, arrays, methods of using probes and arrays, and/or methods for making probes and/or arrays. In the various embodiments, probes include at least two springs separated by a movable stop while in other embodiments, three or more springs may be included with two or more movable stops. Movable stops interact with fixed stops that are either part of the probes themselves or part of separate elements that engage with the probes (such as array frame structures) that provide for the retention, longitudinal and/or lateral positioning of probes and possibly for orientation of the probes about a longitudinal axis. Fixed stops provide for controlled limits for movement of the movable stops which in turn allow for enhanced compliant or elastic performance of the probes upon increased probe compression in either one direction, in the order of tip compressions, or in both directions or tip compression orders (e.g.

Abstract: Disclosed is a detector 10 using a liquid spray 2000 for detecting electrical faults or shorts with the detector including a body 100 having an interior 120; a hose or pipe 130 fluidly connected to interior 120; a trigger valve 140 operatively connected to hose 130; a conductor 200 attached to detector 10; and/or a pump 110 fluidly connected to interior 120. In various embodiments the detector 10 can cause liquid spray 2000 to be sprayed on a subregion of an item such as a remotely operated vehicle to create a closed electrical circuit through the liquid spray and the conductor in the detector.

Abstract: A probe head for testing a device under test integrated on a semiconductor wafer includes a plurality of contact probes, each having a first end and a second end, and at least one first lower guide and one second lower guide at the first end. The guides are parallel to each other and have a respective plurality of first and second guide holes for slidingly housing the contact probes. At least one third lower guide is substantially parallel to the first lower guide and to the second lower guide and includes a plurality of third guide holes for slidingly housing the contact probes. The guide holes are disposed in a shifted arrangement to eliminate a scrub movement of the first ends of each contact probe of the probe head.

Abstract: A measuring system for measuring signals with multiple measurement probes includes a multi probe measurement device having at least two probe interfaces that each couple the multi probe measurement device with at least one of the measurement probes, a data interface that couples the multi probe measurement device to a measurement data receiver, and a processing unit coupled to the at least two probe interfaces that records measurement values via the at least two probe interfaces from the measurement probes. The processing unit is further coupled to the data interface and provides the recorded measurement values to the measurement data receiver that also includes a data interface. The data interface of the measurement data receiver is coupled to the data interface of the multi probe measurement device.

Abstract: The invention relates to a measurement instrument, such as an oscilloscope, comprising a measurement unit adapted to receive an input signal, and a processing unit adapted to classify the input signal, preferably based on signal parameters or characteristics of the input signal. wherein the processing unit is adapted to determine a signal analysis category for the input signal based on said classification of the input signal, and to match the determined signal analysis category to a control configuration, which defines settings and/or configurations of the measurement instrument, based on an adjustment function.

Abstract: A method of operating an oscilloscope is disclosed. The method comprises providing a bit stream comprising pseudo-random data to an oscilloscope across a data path characterized by sufficient signal degradation to prevent the oscilloscope from reliably triggering a sweep of an eye pattern based on receiving the pseudo-random data; inserting a predetermined sequence of bits into the bit stream at predetermined periodic intervals to open the eye pattern sufficiently during each of the periodic intervals to permit the oscilloscope to trigger the sweep of the eye pattern; and generating the eye pattern based at least in part on the pseudo-random data and excluding the predetermined sequence of bits from the sweep of the eye pattern. Oscilloscopes configured to trigger according to a predetermined system of bits at predetermined intervals are also disclosed.

Abstract: A device includes a plurality of resistive voltage dividers connected operationally between a supply line and an electric grounding terminal so as to form separate respective connection paths to the electrical grounding terminal, and a processing assembly connected to the outputs of the voltage dividers and designed to generate signals or data indicating the voltage of the supply line. The processing assembly includes a plurality of separate processing modules each one coupled to a respective one of the connection paths and designed to generate respective signals or data indicating the voltage of the supply line.