Abstract: Methods and devices for diagnosing, monitoring, and/or treating tissue through an opening or port through an airway wall are provided herein.

Abstract: A flexible marker system for use with a computer-assisted surgical (CAS) tracking system is disclosed. The system includes a rigid frame or instrument having a plurality of coupling locations each configured to position a navigation marker in a predetermined position and a flexible array configured to be coupled with the rigid frame or instrument. The flexible array can include an elastically deformable body and a plurality of navigation markers, where the flexible array is configured to be coupled to the rigid frame or instrument by stretching the elastically deformable body over the rigid frame or instrument such that each of the plurality of navigation markers is positioned at one of the plurality of coupling locations of the rigid frame or instrument.

Abstract: Tracking constellations for use with surgical instruments, and associated systems and methods, are disclosed herein. In some embodiments, a tracking constellation includes (i) a support, (ii) a plurality of first standoffs extending from the support to a first height, and (iii) a plurality of second standoffs extending from the support to a second height different than the first height. The tracking constellation can further include a plurality of markers mounted to corresponding ones of the first standoffs or the second standoffs. The markers can lay in a common plane. The support can extend at a generally orthogonal angle to an instrument when the tracking constellation is coupled to the instrument such that the common plane is angled relative to the instrument.

Abstract: A patient tracking device for insertion into an oral cavity includes a sensor housing comprising a first surface shaped to correspond to a pallet within the oral cavity. At least a portion of the first surface affixes the sensor housing to the oral cavity. An electromagnetic sensor is coupled to the sensor housing.

Abstract: This invention is a system and method for utilizing artificial intelligence to operate a surgical robot (e.g., to perform a laminectomy), including a surgical robot, an artificial intelligence guidance system, an image recognition system, an image recognition database, and a database of past procedures with sensor data, electronic medical records, and imaging data. The image recognition system may identify the tissue type present in the patient and if it is the desired tissue type, the AI guidance system may remove a layer of that tissue with the end effector on the surgical robot, and have the surgeon define the tissue type if the image recognition system identified the tissue as anything other than the desired tissue type.

Abstract: Devices, Systems, and Methods for detecting a 3-dimensional position of an object, and surgical automation involving the same. The surgical robot system may include a robot having a robot base, a robot arm coupled to the robot base, and an end-effector coupled to the robot arm. The end-effector, surgical instruments, the patient, and/or other objects to be tracked include active and/or passive tracking markers. Cameras, such as stereophotogrammetric infrared cameras, are able to detect the tracking markers, and the robot determines a 3-dimensional position of the object from the tracking markers.

Abstract: A computer-assisted surgical system includes a function selection system configured to detect an actuation and a de-actuation of a user input mechanism associated with a user control mechanism for controlling a surgical instrument coupled to a manipulator arm of a computer-assisted surgical system, the user input mechanism configured to facilitate activation and deactivation of a clutch mode of operation in which the user control mechanism is decoupled from controlling the surgical instrument. Based on the detecting of the actuation and the de-actuation of the user input mechanism, the function selection system determines information associated with the user input mechanism and the user control mechanism, compares the information to a set of defined criteria, and performs, when the information satisfies the set of defined criteria, a function associated with a different mode of operation of the computer assisted surgical system.

Abstract: A surgical drape for a patient side cart of a teleoperated surgical system may comprise a body sized and shaped to cover at least a portion of an arm or main column of the patient side cart, and an attachment device feature connected to the body, the attachment device feature being configured to install the surgical drape to the arm or main column so as to cover at least a portion of the arm or main column with the surgical drape. In an installed position of the surgical drape on the arm or the main column, the attachment device feature is positioned at a location in sensing proximity of a sensor of the patient side cart.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: A system includes a biometric device, a biometric data collection device, and a spatial categorization system. The biometric device includes a biometric sensor to measure a biometric trait of a user. The biometric data collection device includes a positioning system and a biometric data storage system, and a third wireless transceiver. The positioning system is configured to provide spatial location values specifying a geographic location of the biometric data collection device. The biometric data storage system is configured to assign time stamp values to each of the spatial location values and biometric trait measurements. The spatial categorization system is configured to identify a biometric trait measurement indicating that a condition of the user has a value that exceeds a threshold, and to assign, based on the identified biometric trait measurement, a category identification value to a spatial region corresponding to the spatial location value.

Abstract: A dependency-based startup method in a multi-modality medical processing system that includes receiving initialization information about a plurality of executable components to be started, the plurality of executable components including an executable modality component configured to communicate with a medical device communicatively coupled to the multi-modality medical processing system. The method also includes receiving dependency information about the executable modality component, the dependency information identifying one or more of the executable components upon which the executable modality component depends and transforming the initialization information and the dependency information into a dependency map that represents the dependencies between the plurality of executable components.

Abstract: The present invention discloses indicator fluids, reference indicator fluid, and usage thereof, and systems and methods for assessing movement of molecular substances within, to or from a cerebrospinal fluid, brain or spinal cord compartment of a human cranio-spinal cavity. Indicator fluid moving from the cerebrospinal fluid compartment enables measurements of levels of indicator fluid in blood or urine and assessment of the cranio-spinal cavity's ability to remove molecular substances. The indicator fluids may be contrast agents used for imaging, such as by computed tomography imaging, and magnetic resonance imaging, or imaging utilizing radioactive substances by positron emission tomography, single-photon emission computed tomography or scintigraphy.

Abstract: An instrument for internal mapping includes a flexible elongated portion (702) and an expandable portion (710) coupled distally to the elongated portion, the expandable portion having one or more expandable loops. An array of sensors (706) and electrodes (708) is distributed on the expandable portion and is configured to concurrently register the instrument to real-time images of an anatomy using the sensors and measure electrical characteristics of the anatomy with the electrodes to generate an electro-physiology (EP) map having the anatomy and intensities of the electrical characteristics mapped together in the real-time images.

Abstract: An optical coherence tomography scanning system traverses its respective scan pattern quickly, typically completing an entire two-dimensional frame faster than a conventional raster scanner completes one raster line segment. To traverse the scan pattern quickly, the system takes fewer A-scans per length of scan pattern than a conventional OCT scanner. To compensate for the sparsity of the sample points along the respective scan line segments, and for gaps between respective line segments of the trajectory, the system acquires and combines several partially overlapping frames for each study.

Abstract: An optical sensor and a method of operating the optical sensor are provided. The optical sensor includes a light source configured to emit a light, and a path adjuster configured to adjust a traveling path of the light to reflect the light at a first time, and allow the light to pass through the path adjuster at a second time. The optical sensor further includes a light receiver configured to receive a reference light among the reflected light, and receive, among the light passing through the path adjuster, a measurement light related to a target material.

Abstract: The present disclosure relates to the field of medical monitoring, and, in particular, to non-contact detecting and monitoring of patient breathing. Systems, methods, and computer readable media are described for calculating a change in depth of regions in one or more regions of interest (ROI's) on a patient and assigning one or more visual indicators to the regions based on the calculated changes in depth of the regions over time. In some embodiments, one or more breathing parameter signals corresponding to the regions can be generated and/or analyzed. In these and other embodiments, the one or more visual indicators can be displayed overlaid onto the regions in real-time. In these and still other embodiments, the systems, methods, and/or computer readable media (i) can display one or more generated breathing parameter signals in real-time and/or (ii) can trigger an alert and/or an alarm when a breathing abnormality is detected.

Abstract: Described herein are improved systems and methods for cellular ionic activity visualization. Specifically, for example, the systems and methods can observe and characterize biological ionic channel activity and subsequently detect, measure or manipulate a biological sample in the field of biological or medical sciences on the cellular level. Such a capability can be implemented across any type of biological cell which possesses ionic channels on the surface or contained within.

Abstract: Devices and methods for photoacoustic tomography are disclosed herein. One exemplary photoacoustic tomography device uses a laser to produce acoustic waves in a sample. A transducer receives the acoustic waves through a slit formed by one or more blades positioned substantially parallel to the receiving aperture of the transducer. An acoustic absorber is affixed to each of the one or more blades along a surface proximal to the transducer. A processor acquires acoustic data and reconstructs photoacoustic tomographic images based on the acquired data. Reconstructing the image involves setting reconstruction parameters, defining a reconstruction area, reconstruction position, and pixel size, and calculating an acoustic travelling path for the sample to each transducer element. The acoustic travelling paths are saved into a three-dimensional array.

Abstract: A core body thermometer includes a substrate, a heat receiving terminal with which heat from a subject is received and which divides the heat into first heat flow and second heat flow and causes the first heat flow and the second heat flow to flow out, a first heat flow measurement system that measures the first heat flow using a first input-side temperature sensor and a first output-side temperature sensor, a second heat flow measurement system that measures the second heat flow using a second input-side temperature sensor and a second output-side temperature sensor, a first thermal resistance body provided between the heat receiving terminal and the first input-side temperature sensor, and a second thermal resistance body provided between the heat receiving terminal and the second input-side temperature sensor.

Abstract: The present invention cures patients of viral infection completely, within hours. Through a systematic procedure, the patient will raise and maintain the ambient temperature of a room, subsequently raising their individual body temperature. The patient must remain in this heated space for a designated period of time, following the procedural steps of staying hydrated, consuming the necessary nutrients and electrolytes, showering periodically, wrapping the body in a double-layered sweat suit of some kind, and monitoring their body's temperature and response throughout. The body's reaction to viral infection is to raise its internal temperature; the present invention utilizes this natural immune system response by enhancing and intensifying it, with the goal of eliminating the virus completely.

Abstract: A Percutaneous Coronary Intervention (PCI) guidewire and method of use includes at least two pairs of small surface area, closely spaced electrodes spaced axially along the length of the guidewire to allow one electrode pair to be positioned on each side of a coronary stenosis. The electrodes can sense electrical signals from the myocardium immediately adjacent to the electrodes, enabling the guidewire to record and analyze an Intra-Coronary Electrogram (ICEG) and heart pacing, and, therefore, facilitate more accurately diagnosis of an individual patient's stenosis and provide a more patient specific diagnosis of clinical need.

Abstract: A non-invasive electronic patient monitor tracks one or more physiological parameters of a patient, such as intravascular volume index (IVI), extravascular volume index (EVI), total hemoglobin (SpHb), impedance, and/or weight. The patient monitor determines if one or more of the physiological parameters are within a predetermined range. The patient monitor activates an alarm if one or more of the physiological parameters are outside the predetermined range and indicates a patient can be experiencing edema and/or heart failure, or sepsis.

Abstract: An earphone includes a loudspeaker, a microphone, a housing supporting the loudspeaker and microphone, and an ear tip surrounding the housing and configured to acoustically couple both the loudspeaker and the microphone to an ear canal of a user, and to acoustically close the entrance to the user's ear canal. A processor receives input audio signals from the microphone, detects peaks having a frequency of around 1 Hz in the input audio signals, based on the detected peaks, computes an instantaneous heart rate, measures a frequency of an oscillation within the instantaneous heart rate, and based on the frequency of the oscillation, computes a rate of respiration.

Abstract: A pulse diagnosis apparatus includes a base, a bearing and a plurality of sensing module. The base has a motion module. The motion module is disposed on the base and moves back and forward in a first direction. The bearing is disposed on the motion module and includes a first face and a second face. Each sensing module includes a driving element, a flexible element and a sensing unit. The driving element moves in the first direction and passes through the bearing. The driving element includes a first terminal and a second terminal. The first terminal is adjacent to the second face. The second terminal is adjacent to the first face. The flexible element is hitched up the driving element. Two terminals of the flexible element are against the second terminal and the bearing. The sensing unit is disposed on the second terminal.

Abstract: A non-invasive blood pressure monitoring device includes an inflatable blood pressure cuff, a pump device for pressurizing the cuff, a pressure sensor to monitor blood pressure as physiological parameter, and an electrically actuated, normally-open solenoid valve configured to maintain a cuff pressure. A control unit configured to regulate a valve hold value for holding the normally-open solenoid valve at a desired closed position, wherein the valve hold value is at least one of a voltage value and a current value for controlling actuation of the normally-open solenoid valve. At least one inertial sensor configured to detect and transmit motion signals representative of external motions applied to the portable medical device, wherein the control unit is configured to regulate the valve hold value as a function of the motion signals of the at least one inertial sensor to maintain the normally-open solenoid valve in the closed position.

Abstract: An example electronic device may include a detection circuit and a processor operatively connected to the detection circuit. The processor may be configured to obtain a first signal associated with an external object through the detection circuit; obtain a first HR, using a first filter having an attribute of a first frequency band; obtain a second HR, using a second filter having an attribute of a second frequency band, based at least on the first signal; change at least some attributes associated with the second filter, based at least on the first HR and the second HR; obtain a second signal associated with the external object through the detection circuit; and generate heart rate variability (HRV) information, using the second filter, in which the at least some attributes are changed, based on the second signal.

Abstract: A cardiovascular monitoring system includes a first monitoring device configured to couple to a first body part of a subject and a second monitoring device configured to couple to a second body part of the subject. The first monitoring device is configured to measure a first cardiovascular signal and a first motion signal at the first body part, and the second monitoring device is configured to measure a second cardiovascular signal and a second motion signal at the second body part. A controller of the system receives the first and second cardiovascular signals and the first and second motion signals and filters the first and second cardiovascular signals by removing spectral components that correspond to spectral components of the first and second motion signals. Based on a correlated spectral component that is present in both the filtered first and second cardiovascular signals, the system determines cardiovascular information of the subject.

Abstract: An apparatus for obtaining bio-information may include a pulse wave sensor including a light source and a detector. The light source is configured to emit multi-wavelength light to an object of interest and the detector is configured to detect light reflected from the object. In addition, the apparatus may include a processor configured to obtain a change in volume of a blood vessel based on one or more of quantity of detected multi-wavelength light and absorbance coefficients of respective wavelengths of the multi-wavelength light and obtain bio-information based on the measured change in volume of the blood vessel.

Abstract: A magnetic induction molecular imaging method and a magnetic induction molecular imaging system for biological tissue detection, comprises a detection bed, a magnetic nanoparticle device, a magnetic field generating device, a signal receiving and transmitting device, a magnetic field signal acquisition device and computer equipment, wherein the magnetic nanoparticle device is used for sending magnetic nanoparticles to a to-be-detected area of the detection bed; the magnetic field generating device is used for generating and transmitting electromagnetic waves to the signal receiving and transmitting device; the signal receiving and transmitting device is used for receiving the electromagnetic waves transmitted by the magnetic field generating device; the magnetic field signal acquisition device is used for acquiring scattered electric field information and scattered magnetic field information, based on the magnetic nanoparticles, of the to-be-detected area detected by each sensor on sensor arrays.

Abstract: A system and method of tracking a flexible elongate instrument within a patient is disclosed herein. The system is configured to obtain remote localization measurement data of the flexible elongate instrument and obtain elongation measurement data of the flexible elongate instrument. This data is combined and transformed to a coordinate reference frame to produce a localization of the flexible elongate instrument that is more accurate than the remote localization measurements or elongation measurement data alone. The combined localization is then provided to a localization consumer.

Abstract: In accordance with embodiments, methods and systems for utilizing multiple threshold checkers are provided. A range sensor collects measurement data. The range sensor examines the measurement data based on multiple threshold checkers to determine satisfaction of a trigger condition. In response to the satisfaction of the trigger condition, the range sensor provides the measurement data to a host computing device of the range sensor.

Abstract: A method for measuring levels of specific biomarkers in exhaled breath. Specific compounds such as nitric oxide and isoprene can be monitored from a subject's breath. The resultant measurements can provide indications of the subject's medical condition, or response to an applied stress.

Abstract: There is provided a computer-implemented device comprising a processor, a machine readable medium storing instructions, the instructions when executed by the processor for configuring the device for: receiving an airflow and volume signal from at least one airflow and volume sensor for a plurality of patients; digitizing the signal to a digital signal and segmenting the signal using a sliding window to extract a plurality of features from the digital signal comprising: peak-to-peak amplitude, root mean square, integral of the absolute values, zero-crossing rate, standard deviation of a first derivative, mean value; normalizing the plurality of extracted features; and, using the normalized plurality of extracted features and an input indicating sleep apnea severity to train a machine learning algorithm and generate a mathematical model for subsequent use in classifying airflow and volume sensed signals received for a particular patient during wakefulness as normal or sleep apnea.

Abstract: Measurement of airway resistance and/or lung compliance during non forced exhalation is performed using initial occlusion of exhalation followed by removal of the occlusion or opening of a shutter. The measurement device can use a single sensor to measure both pressure and flow. A pressure monitor can detect that exhalation is improperly forced to signal an error or to reject a pressure and flow measurement from a forced exhalation trial.

Abstract: The present invention relates to the field of medical monitoring, and in particular non-contact, video-based monitoring of pulse rate, respiration rate, motion, and oxygen saturation. Systems and methods are described for capturing images of a patient, producing intensity signals from the images, filtering those signals to focus on a physiologic component, and measuring a vital sign from the filtered signals. Examples include flood fill methods and skin tone filtering methods.

Abstract: Systems, devices, and methods for providing procedure-specific workflow guidance are provided. The workflow guidance may include providing selectable options on a display device to a user including a selectable option to select a target vessel and a prompt to move an intravascular imaging device within the selected target vessel. Imaging data is received from the intravascular imaging device within the selected target vessel. The workflow guidance may be used to identify an area of interest within the selected target vessel and automatically display vessel measurements corresponding with the area of interest on the display device.

Abstract: A management device is used in an assistive device configured to assist an erecting action and a seating action of a care receiver and records, as a log data, an action history including erecting actions and seating actions. The management device for the assistive device includes a detecting section for detecting, in the log data, a cycle action executed in the order of the erecting action and then the seating action, and a determination section for determining, based on the log data, whether the cycle action detected is a transfer action in which the care receiver is transferred.

Abstract: A caregiver assistance system is disclosed for helping caregivers manage the care of existing bed sores and/or reduce the risk of a patient developing bed sores. The system may also help the caregiver to perform rounding tasks and/or to reduce the likelihood of patient falls. The system comprises a server application in communication with the patient's bed and one or more mobile electronic devices (e.g. smart phones). The mobile devices receive individual assessments of a plurality of bed sore risk factors and forward them to the server. The server generates bed sore risk scores from the answers and forward them to an EMR server. The server may also determine one or more risk reduction steps, display them on the mobile electronic device, and/or forward them to the patients' beds for implementation thereon. Additional bed sore information may be captured and sent to the EMR.

Abstract: The present invention provides a method for the production of a metal halide adduct of S4N4, in particular a specific copper adduct of S4N4, for the visualisation of a print on an object, in particular a fingerprint on a metal object. The present invention also provides a method and apparatus for visualising a print on an object, using S2N2 obtained from a metal halide adduct of S4N4.

Abstract: The present invention is both a device and a method for verifying a subject's identity while using a medical device or undergoing a medical diagnostic or therapeutic procedure, particularly at home or at a remote location. The method and device can be used for inpatient and remote sleep and signal analysis with biometric identification. The present invention is further related to the devices and sensors used in executing the method, and includes various embodiments of a method of inpatient and remote sleep analysis.

Abstract: Acoustic immittance and other characteristics of ears may be determined by measuring eardrum displacements resulting from application of pressure to the eardrum. For example, optical coherence tomography may be applied to monitor eardrum displacements responsive to a sound. The pressure corresponding to the sound is measured by a suitable instrument such as a microphone. The measured displacements and pressures may be processed to obtain a measure of immitance.

Abstract: A physiological signal monitoring device includes a biosensor, and a transmitter including a bottom casing, a processing unit and a battery. The bottom casing has a first stepped section, a second stepped section, and a riser section interconnecting the first stepped section and the second stepped section. The processing unit corresponds in position to the first stepped section. The battery corresponds in position to the first stepped section, and is configured not to overlap the processing unit in a direction of a first axis so as to reduce a thickness of the transmitter.

Abstract: The present disclosure provides devices, methods and systems for analyte detection and/or monitoring, e.g., the continuous and/or semi-continuous monitoring of in-vivo analyte concentrations in real time. Generally, the devices, methods and systems of the present disclosure make use of signaling probes; methods or devices for reducing interferent-based fouling of the signaling probes, non-specific binding to the signaling probes and/or occlusion of a sensor surface; and methods and/or devices for providing an adjusted signal based on a detected signal from the signaling probes. Compositions including conformation switching signaling probes are also provided.

Abstract: Disclosed is a portable device for processing continuous monitoring data. The portable device includes a data interface that receives a stream of continuous monitoring data from a body-worn sensor. The data is indicative of an analyte in a bodily fluid. The portable device also includes a storage device that can store the continuous monitoring data. The control processes the continuous monitoring data and is switchable between first and second modes of operation during a sensor session of the body-worn sensor. In the first mode of operation, the control is configured to provide video data indicative of the continuous monitoring data for outputting by a display. In the second mode of operation the control is configured to store the continuous monitoring data in the storage device and to block the continuous monitoring data from being displayed on the display. A related method, system and computer program product are also disclosed.

Abstract: An analyte monitoring system may include an analyte sensor and a transceiver. The analyte sensor may include one or more sensors and a transceiver interface. The one or more sensors may be configured to generate sensor measurements indicative of an analyte level in a first medium. The sensors may include a temperature transducer configured to generate a sensor temperature measurement, and the sensor measurements may include the sensor temperature measurement. The transceiver interface may be configured to convey the sensor measurements. The transceiver may include a sensor interface and a processor. The sensor interface may be configured to receive the sensor measurements conveyed by the analyte sensor. The processor may be configured to adjust the sensor temperature measurement and calculate an analyte level in a second medium using at least the adjusted sensor temperature measurement and one or more of the sensor measurements.

Abstract: Various examples are directed to systems and methods for measuring a parameter related to patient health. An analyte sensor system may detect that the analyte sensor system has been applied to a host and may store analyte data describing the host. The analyte sensor system may determine that sensor use at the analyte sensor system has terminated and upload stored analyte data to an upload computing device.

Abstract: A fully implantable sensor for detecting an analyte in a body fluid sample is disclosed. The sensor includes a chamber plate that receives the body fluid sample. The chamber plate has a biocompatible polymer membrane having a molecular weight cutoff of at least 15 kDa. The sensor also includes a quantum cascade laser illumination source that generates an illumination light beam in a spectral range and transmits the light beam to the chamber plate. In response to the illumination light beam at least partially illuminating the chamber plate, the chamber plate generates a reflection light beam that at least partially illuminates the body fluid sample within the chamber plate. The sensor has an optical detector that detects at least one property of the reflection light beam and generates a sensor signal that correlates to the presence of the analyte. The sensor includes a controller to evaluate the sensor signal.

Abstract: Provided are implantable probes for analyzing biological fluids and related methods of using and making. The probe is formed with an integrated on-chip probe body that provides for collection and storage of analyte from biological fluid and facilitates subsequent analysis, including by a mass spectrometer (MS). The analysis has high spatial accuracy as the probe tip that collects biological fluid sample is small, including less than 100 ?m with an opening less than 10 ?m. Temporal information can be obtained by storing the analyte from the biological fluid as a train of droplets separated by an immiscible fluid. The probe body can be electrically energized to facilitate sample ionization and transfer to a MS analysis device. In this manner, the integrated on-chip probe body facilitates analyte collection, storage and subsequent analysis within a single probe body material, including a doped silicon material.

Abstract: Systems and methods of in vivo hydroxyl radical protein foot-printing are presented. These teachings may be used to, for example, study three-dimensional protein structure or bio-kinetics. Radical Dosimetry including an optional intrinsic standard is used on isolated intact cells. Real-time feedback based on an internal standard provides comparability between different experiments and in vivo analysis results in data that is representative of actual biological conditions.

Abstract: An oximeter probe is user configurable for being in an absolute reporting mode and a relativey reporting mode for measured values. The measured values for the absolute and relative modes include absolute oxygen saturation, relative oxygen saturation, absolute hemoglobin content, relative hemoglobin content, absolute blood volume, relative blood volume. The relative modes and absolute modes for determining and reporting relative or absolute hemoglobin content or relative or absolute blood volume for individual patients are beneficial when determining the efficacy of administered medications, such as epinephrine, that effect blood flow, but not oxygen saturation, in tissue, such as skin. The oximeter probe in these relative modes displays the efficacy of the administered medication as reported values for relative hemoglobin content or relative blood volume fall or rise.