Abstract: An atomizer includes an e-liquid tank. The e-liquid tank includes an e-liquid chamber and an air vent communicating with the e-liquid chamber.

Abstract: An arrangement for an inhaler comprises at least one electric evaporator for evaporating liquid supplied from the evaporator, and for adding the evaporated liquid to an air flow flowing through the inhaler to form an aerosol, and a flow rate measuring arrangement for measuring the volume and/or mass flow of the air flow flowing through the inhaler. The flow rate measuring arrangement comprises a heating device, a downstream temperature sensor arranged downstream of the heating device for measuring an air outlet temperature and an electronic control device, wherein the electronic control device is adapted to determine the volume and/or mass flow of the air flow flowing through the inhaler on the basis of a temperature difference between the air outlet temperature and an air inlet temperature of the air flow upstream of the heating device.

Abstract: A cartridge of an electronic vaping device includes a housing extending in a longitudinal direction. The housing includes a sidewall, a transverse wall at the first end of the sidewall, and an inner tube integrally formed with the housing. The sidewall is generally cylindrical and a first end and a second end. The transverse wall includes at least one outlet therein. The inner tube extends in the longitudinal direction. The inner tube is concentrically positioned with respect to the sidewall. The inner tube communicates with the at least one outlet. The cartridge also includes a reservoir between the sidewall and the inner tube. The reservoir is configured to contain a pre-vapor formulation.

Abstract: A breathing assistance device with improved pressure characteristics is capable of providing a high level of CPAP per unit of supplementary respirable gas consumed while maintaining low CPAP fluctuations throughout the breath cycle. The invention also includes a manometer for monitoring pressure and a safety pressure relief valve as additional safety measures against overpressure delivered to a patient. In some embodiments, the device is disposable for one-time or single patient use.

Abstract: The invention provides a compound, namely acetylsalicylic acid (ASA) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising ASA or a pharmaceutically acceptable salt thereof, for use in the treatment of a patient, e.g. a human being, suffering from a severe influenza virus infection and/or a symptom or condition associated therewith (namely, nasal congestion, sore throat, cough, fever, fatigue, headache and myalgias), wherein said use comprises the administration of a composition comprising ASA or a pharmaceutically acceptable salt thereof to the patient by inhalation.

Abstract: A manifold that allows for increased flow performance, at a reduced pressure, and a flow path that is easily maintained, and fluid dispensing systems that allow for the precise, controlled spacing of beads of multiple component adhesives, and other liquids, and allow for multiple beads to be dispensed onto a substrate simultaneously are disclosed. A control portion for a manifold that solves the disadvantages relating to sealing an open channel and a carrier that provides a mechanism for applying an adhesive and/or a two-part adhesive easier are disclosed.

Abstract: An inhaler comprising an elongate housing containing a reservoir of inhalable composition. An outlet for the composition and suction port are provided at one end of the housing. A diaphragm is mounted in the housing defining a suction chamber such that suction on the suction port reduces the size of the suction chamber. An elongate leaf spring is mounted at one end to the housing at the end of the suction chamber opposite to the suction port, and is pivotally mounted at an intermediate portion about a pivot point. A valve element is at the end of the leaf spring opposite to the one end and is biased closed. Suction on the suction port deflects the diaphragm and hence the leaf spring between the one end and the pivot point causing the opposite end of the leaf spring to pivot about the pivot point thereby causing the valve element to open.

Abstract: Headgear for use with a respiratory mask is described. The headgear comprises a continuous and substantially curved elongate member extending in use below a user's nose and at least two headgear straps capable of attachment to the ends of the elongate member. A mask attachment on the elongate member is disposed to sit below or on one of said user's nose, mouth, upper lip and an inlet to the mask. The attachment is capable of receiving the mask.

Abstract: A spirometer comprises a housing defining a fluid flow pathway extending between a first end and a second end, a first opening along the pathway and a second opening longitudinally spaced along the pathway from the first opening. A flow chamber defining a fluid flow pathway is disposed within the housing between the first opening and the second opening, the flow chamber including an elongated resistive element along the central longitudinal axis of the flow chamber for defining a flow passage through the flow chamber between the resistive element and the inner surface of the flow chamber. The flow chamber conditions fluid flow for accurate sensing of the fluid flow over a range. A pressure sensor is disposed within the housing in fluid communication with the first opening and the second opening for sensing a pressure differential between the first opening and the second opening and producing an electric signal that corresponds with the rate of fluid flow through the housing.

Abstract: An apparatus such as a fluid mixer, suitable for use with a respirator, including a venturi nozzle for flow of a pressure-controlled fluid; an ambient fluid aperture in fluid communication with the venturi nozzle; a fluid port; a pressure force multiplier in fluid communication with the fluid port; and a valve moveable relative to the venturi nozzle between a start flow position and a stop flow position; where the pressure force multiplier is configured such that fluid forced into the fluid port actuates the valve relative to the venturi nozzle; and where the pressure force multiplier is configured such that fluid withdrawn from the fluid port actuates the valve relative to the venturi nozzle. A method of using an apparatus suitable for a ventilator is also disclosed.

Abstract: A method of molecular self-assembly is disclosed using two interacting streams that are allowed to interact and are subsequently forced through an orifice. A first stream of a dope solution of polymer molecules is extruded out of a capillary. The dope stream is surrounded by a focusing fluid which is miscible with the dope solution. The interaction between the jet of dope solution and surrounding focusing fluid creates hydrodynamic stretching and allows for extracting solvent from the dope solution. Concentrated polymers within the solution at stretched regions of the jet interact, and finally self-assembly takes place after the fluids are forced through the outlet of a converging nozzle. The formation of the structure can be optionally completed in a coagulating space. The structures thus obtained such as fibers or threads can be wound onto a mandrel.

Abstract: A gas washout vent, and a patient interface with the gas washout vent, configured to allow patient-exhaled CO2 to flow to an exterior of the plenum chamber to minimise rebreathing of exhaled CO2 by the patient, the gas washout vent including at least one outlet orifice; a diffusing member at least partly covering the outlet orifice; and a blocking member having an air-impermeable material, the blocking member preventing gas exiting from the outlet orifice from flowing straight through the diffusing member.

Abstract: An accessory for a nasal mucus aspirator includes an accessory body suitable to be gripped and a terminal nozzle placed at a distal end of said accessory body and suitable to be at least partially inserted into a nostril of a user. In the accessory body, there are formed a compressed air inlet passage suitable to be fluidically connected to a compressed air source for receiving a flow of air at a positive pressure, said compressed air inlet passage defining a constriction so as to generate a Venturi effect, and an aspiration duct flowing into said constriction and fluidically connected to the terminal nozzle so as to generate a negative pressure due to the Venturi effect suitable to aspirate the mucus.

Abstract: An inductive heating assembly for generating an aerosol from an aerosol precursor material in an aerosol provision system, the inductive heating assembly including: a susceptor; and a drive coil arranged to induce current flow in the susceptor to heat the susceptor and vaporize aerosol precursor material in proximity with a surface of the susceptor, and wherein the susceptor includes regions of different susceptibility to induced current flow from the drive coil, such that when in use the surface of the susceptor in the regions of different susceptibility are heated to different temperatures by the current flow induced by the drive coil.

Abstract: A medical face mask is provided which includes a mask body having a mask interior and contoured to fit against the face of a patient. A permanently-open nasal aperture is provided in the mask body to facilitate insertion of an equipment, instrument or device into the mask interior and into the nose of the patient. A permanently-open oral aperture is provided in the mask body to facilitate insertion of an equipment, instrument or device into the mask interior and into the mouth of the patient. A one-way oxygen port is provided in the mask body to facilitate introduction of oxygen and/or medical gases into the mask interior of the mask body. A one-way valve port is provided in the mask body to facilitate discharge of carbon dioxide from the mask interior. A capnography or gas sampling port may be provided in the mask body to capture gases for analysis.

Abstract: A vapour producing device has a power supply, a heater powered by the power supply, a heating chamber heated by the heater, and a vapour outlet, in which a removable container is disposed in the heating chamber. The removable container has a vapour permeable membrane enclosing a herbal vapour producing material to be heated.

Abstract: Method and apparatus for providing percussive ventilation therapy to a patient airway preferably includes at least one driver unit configured to provide pressurized, non-pulsate gas. At least one patient interface device preferably has structure configured to (i) receive the pressurized, non-pulsate gas from the at least one driver unit and transform it into a pulsed and pressurized gas, and (ii) supply at least one sub tidal volume of pulsed and pressurized gas to a patient through a patient connection orifice. At least one flexible tube is preferably configured to provide pressurized, non-pulsate gas from the at least one driver unit to the at least one patient interface device. Preferably, at least one portion of the patient interface device is disposable, and another portion may be reusable. Preferably, the invention uses Adaptive Dynamic Subtidal Ventilation technology.

Abstract: An electronic smoking article includes an aerosol generator and a mouth end insert. The mouth end insert includes a mechanical aerosol converter surface having the capacity to improve characteristics of aerosol produced by the aerosol generator, including sensory attributes.

Abstract: Gas flow reversing element (1) for the use of a gas supply (14) under excess pressure, in particular inspiratory gases, for selectively generating a gas flow (8) from or to a line connector (6) which can in particular be connected to an airway of a patient, said gas flow reversing element (1) being designed as a main piece (2), the main piece (2) at least comprising an inflow region (9), a nozzle region (15) and a mixing region (16), and further a branching piece (3), the inflow region (9) connecting a pressure connector (4), for connection to the gas supply (14), to at least one closable outlet opening (5) arranged in the mixing region (16), and the branching piece (3) connecting the nozzle region (15) of the main piece (2) to the line connector (6), wherein a nozzle (7), particularly an injector nozzle, is configured and arranged in the nozzle region (15) in such a way that, a gas flow (8) flowing along a first flow path (20) through the main piece (2) from the pressure connector (4) subsequently through th

Abstract: An apparatus for aerosolized powder delivery includes first and second chambers containing gas at first and second pressures, respectively, above atmospheric pressure. A powder is contained within the first or second chamber. The first chamber has a first external wall and a separating wall shared with the second chamber. The first external wall or the separating wall is configured to rupture if the pressure difference across it becomes equal to or greater than a threshold pressure difference. Specifically, the apparatus is configured so that the difference between the second pressure and atmospheric pressure is greater than the threshold pressure difference. Initially, the difference between the second and first pressures is less than the pressure difference required to rupture the separating wall, and the difference between the first pressure and atmospheric pressure is less than the pressure difference required to rupture the first external wall.

Abstract: The invention provides stable liquid formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention further provides methods for treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering the liquid formulations of the present invention both intranasally and sublingually to a patient in need thereof. Further, the invention provides a method of treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering intranasally and sublingually the naloxone formulations of the present invention.

Abstract: A gas washout vent, and a patient interface with the gas washout vent, configured to allow patient-exhaled CO2 to flow to an exterior of the plenum chamber to minimise rebreathing of exhaled CO2 by the patient, the gas washout vent including at least one outlet orifice; a diffusing member at least partly covering the outlet orifice; and a blocking member having an air-impermeable material, the blocking member preventing gas exiting from the outlet orifice from flowing straight through the diffusing member.

Abstract: The present invention provides a substrate analysis nozzle that reliably prevents a leakage (release) of analysis solution from the nozzle even in the case of a highly hydrophilic substrate and that collects the analysis solution with a high collection ratio after scanning. The present invention is directed to a substrate analysis nozzle configured to discharge an analysis solution from a tip of the substrate analysis nozzle onto a substrate, configured to scan a surface of the substrate using the discharged analysis solution, and configured to suck the analysis solution. The substrate analysis nozzle has a triple-tube structure made up of: a pipe through which the analysis solution is discharged and sucked; a first outer tube surrounding the pipe and surrounding the analysis solution used for scanning; and a second outer tube surrounding the first outer tube.

Abstract: A nebulizer includes a housing having a chamber for holding an aerosol, an air outlet communicating with the chamber for permitting the aerosol to be withdrawn from the chamber, and a reservoir for holding a liquid to be aerosolized. The nebulizer also includes a liquid orifice located in the chamber, one or more liquid channels defined between the reservoir and the liquid orifice, the one or more liquid channels having a liquid volume, and a pressurized gas outlet located in the chamber adjacent to the liquid orifice. A baffle is located in the chamber and positioned relative to the pressurized gas outlet and the liquid outlet so as to divert pressurized gas from the pressurized gas outlet and over the liquid orifice. The baffle has a diverter surface area. The liquid volume is at least 80 mm3. The diverter surface area is less than 5.0 mm2.

Abstract: A method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described.

Abstract: A versatile subject bed for use with one or more test subjects that is configured to keep the subjects sedated throughout either a surgical procedure or imaging process. In embodiments, the subject bed can include interchangeable manifolds allowing the platform to hold up to four subjects at the same time. The interchangeable manifolds can include configurations designed to provide for a single subject, two subjects or four subjects. The four-subject manifold can include an elevated platform that holds two subject side by side and allows the subjects to be stacked during imaging or other procedures. The subject bed can also incorporate an integrated anesthesia channel. Various embodiments include a docking mechanism for easy connection of anesthesia to the platform, as well as an adapter for fitting smaller or multiple subjects simultaneously within the subject bed.

Abstract: An exemplary electronic cigarette includes a power supply and an atomizer. The atomizer is connected with the power supply via a detachable connecting structure. The power supply has a connecting end connecting with the atomizer. The power supply includes an electromagnetic induction coil at the connecting end. The atomizer includes a housing, a liquid chamber arranged in the housing, and a metallic element. The metallic element is capable of generating heat in an alternating magnetic field. The liquid chamber defines an opening facing the power supply. The atomizer further includes a liquid storing element arranged in the opening. The liquid storing element is capable of storing tobacco liquid, and preventing tobacco liquid in the liquid chamber from flowing out. The metallic element abuts against the liquid storing element. The metallic element is configured for heating the tobacco liquid absorbed in the liquid storing element to form aerosol.

Abstract: The present invention provides a two-step mechanism for delivering a flowable substance to the nasal passages, comprising: a. a nosepiece adapted to be in fluid connection with said nasal passages; b. at least one air-tight enclosure, comprising predetermined amount of compressed gas in the same; said compressed gas is pressurized to predetermined amount of pressure; c. a charging mechanism, fluidly connected with said air-tight enclosure, characterized by at least two configurations: a retracted position and an extended position; where, when said charging mechanism is transformed from said extended position to said retracted position, said charging mechanism is adapted to enable delivery of said pressurized and predetermined amount of compressed gas from at least one first predetermined position in said air-tight enclosure to at least one second predetermined position; d. an activation mechanism, adapted to entrain said flowable substance within said pressurized and predetermined amount of compressed gas.

Abstract: An inhaler according to an embodiment has a breath operated valve with a valve element biased closed by a spring and a diaphragm arranged to deform when suction is applied to an outlet end generating low pressure above the diaphragm to lift the valve element against the biasing force of the spring allowing composition to flow out of the inhaler. The spring is a strip of resilient material forming a u-shape with a first arm extending from a position adjacent to the valve element along the diaphragm in a direction away from the outlet end so as to support the diaphragm to an apex where it extends away from the diaphragm into a second arm extending back towards the outlet end, the second arm engaging with the housing to generate a biasing force to urge the valve element closed.

Abstract: The present invention is an oral hygiene system for providing pressurized water to a person's teeth or gums for oral hygiene. The oral hygiene system includes a main valve assembly, a filter assembly, a pressure tank assembly, a syphon assembly and a waterpik assembly. The main valve assembly is connectable to a water line, and includes a valve unit for controlling water flow. The filter assembly includes a filter cartridge, and is in fluid communication with the main valve assembly. The pressure tank assembly is in fluid communication with the filter assembly. The syphon assembly is capable of storing a liquid, and can include a syphon tube capable of dispensing the liquid into the water received from the pressure tank assembly. The waterpik assembly is in fluid communication with the syphon assembly, and is capable of allowing a user to provide pressurized water to a person's teeth or gums.

Abstract: The invention at hand relates to a tracheal applicator for enabling administering high flow therapy to tracheotomy patients, as is known from transnasal insufflation by means of TNI devices and has proven successful. This is attained by an optimized physical simulation of the conditions as available when performing transnasal high flow therapy at the nostril with an inserted prong. The flow of inspiration and expiration flowing through the tracheal applicator is conducted nearly free of turbulences and vortexes owing to further constructive measures while simultaneously preserving an open ventilation system.

Abstract: An aerosol-generating system for oral or nasal delivery of a generated aerosol to a user is provided, including a heater element configured to heat an aerosol-forming substrate to generate an aerosol; a power source; a controller configured to control operation of the heater element, the controller being configured to detect a change in air flow past the heater element: a first data storage recording detected changes in airflow past the heater element and data relating to the operation of the heater element; a second data storage including a database relating changes in airflow and data relating to the operation of the heater element to the properties of the aerosol delivered to the user; and an indicator coupled to the second data storage configured to indicate to the user a property of the aerosol delivered to the user.

Abstract: The invention provides stable liquid formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention further provides methods for treating opioid overdose, opioid dependence, and congenital insensitivity to pain with anhidrosis by administering the liquid formulations of the present invention intranasally to a patient in need thereof. Further, the invention provides a method of treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering intranasally the naloxone formulations of the present invention.

Abstract: A vibrator unit may be configured to vibrate a target material in a target channel and include a vibration element configured to vibrate in response to an external electrical signal having a predetermined frequency. A resonance frequency of the vibration element may be different from the predetermined frequency of the electrical signal. A vibrator unit may include a vibration transmission member in contact with the first member including the target channel in interior; and a vibration element that is in contact with the vibration transmission member. A mode-1 natural frequency of the vibration transmission member may be different from a resonance frequency of the vibration element.

Abstract: An aerosol generator for generating an inhalation aerosol from an inhalation liquid, includes an intake duct for guiding air to a mouth of a user, and a nozzle, arranged in the intake duct for injecting the inhalation liquid into the intake duct. The nozzle is arranged for generating a Rayleigh droplet train of the inhalation liquid propagating along a droplet train propagation path. The intake duct includes at least two first orifices having at least partly opposing discharging directions extending towards the droplet train propagation path. The at least two first orifices are configured for providing respective first air streams in at least partly opposing directions so as to interact in the droplet train propagation path.

Abstract: An actuator for an inhaler, in particular a nasal actuator, is disclosed, the actuator comprising a body, a stem post and fixing means for fixing the stem post in the body. The body comprises a delivery passage for delivery of a medicament and a canister opening for insertion of a canister having a metering valve with a valve stem. The stem post comprises a stem socket for receiving the valve stem of a canister and comprises an orifice for discharging a medicament to the delivery passage. The stem post and body are adapted so they cooperate to define a transition chamber when the stem post is fixed in the body. Also disclosed is a method of forming an component for an actuator for an inhaler, and a method of assembling an actuator for an inhaler by inserting the stem post through the canister opening and into the body thereby.

Abstract: A CPAP device for delivering pressurized, humidified breathable gas for a patient includes a flow generator configured to pressurize a flow of breathable gas. The flow generator includes an air outlet and a removable water container configured to humidify the pressurized breathable gas received from the flow generator. The water container includes an air inlet and an air outlet. The CPAP device further includes a first elastomeric face seal configured to sealingly abut against a substantially flat portion of the water container surrounding the water container air inlet, the first elastomeric face seal being located at an intermediate position between the flow generator air outlet and the water container air inlet when the water container is placed into position to pneumatically communicate with the flow generator.

Abstract: A system for delivering a therapeutic amount of nitric oxide can include a reservoir assembly, a gas supply, and a delivery conduit including a first cartridge, wherein the first cartridge can include a surface-activated material saturated with an aqueous solution of a reducing agent. In certain embodiments, the reservoir includes a restrictor.

Abstract: An apparatus for deagglomerating and aerosolizing particulate matter such as powders, the apparatus including a rotatable turntable having a plurality of circumferentially spaced wells adapted to contain a powder. A pair of conduits are fluidly connected to the turntable wells so that powder from the wells is inducted and drawn to two nozzles so that the powder is entrained in the gas flow exiting each nozzle. Furthermore, the nozzle outlets are aligned and spaced apart from each other, but positioned to direct their particle entrained gas flow in the opposite and facing direction to one another so that the flow from each nozzle impinges upon the flow from the other nozzle to further air mill and deagglomerate the individual powder particles.

Abstract: A fluid dispersion assembly comprises a diffusion unit disposed in fluid communication with a fluid container, the assembly being powered by a compressed air source. The diffusion unit at least partially defines a diffusion chamber, and includes a diffusion assembly containing an atomizer assembly which, in combination with the diffusion chamber, generates a fluid dispersion from a mixture of compressed air and an operative fluid, for example, fragrant oils, essential oils, odor neutralizers, disinfectants such as triethylene glycol, air sanitizers, etc.

Abstract: An air treatment system is provided which includes an appliance and a replaceable cartridge installable therein. The replaceable cartridge contains a liquid compound to be aerosolized and has a cartridge outlet through which the aerosolized compound is discharged during operation. A pump is provided to supply air to the replaceable cartridge to generate the aerosolized compound from the liquid compound contained in the replaceable cartridge, and a controller is provided for controlling the pump to supply the air to the replaceable cartridge to generate and discharge the aerosolized compound from the appliance. The appliance may further include a lift mechanism to assist in receiving the cartridge and moving the cartridge from a loading position to an operational position. The appliance may also communicate with a smartphone or other external device to provide additional functionality.

Abstract: A nebulizer is provided that includes an internal medication chamber and a pressurized gas diverter. The internal medication chamber is configured for holding a medication. The pressurized gas diverter includes a diverter orifice.

Abstract: A three-way air flow connector element is provided for operably introducing nebulized medication into an existing oxygen therapy line, which does not require the user to remove the oxygen line to administer the medication. The connector comprises a first and second female connector end and a third male connector end. The first female connector end is adapted to connect to an oxygen line while the third male connector end is adapted to connect to a patient mask, whereby oxygen can be delivered to the patient therethrough. The second female connector end is an operably opened conduit through which a nebulized medication can be introduced to the patient. This end is capped and removably opened by a medical professional, whereby the patient is not deprived of oxygen when connection is made with a nebulizer or similar oral medication delivery system.

Abstract: A nebulizer for efficiently and reliably delivering aerosolized fluid to an inhaling patient is disclosed. The nebulizer includes a fixed diverter and a movable fluid orifice or fluid pathway connected with an actuator for responding to an inhalation or a manual actuation and beginning the nebulization process. Also provided is a method of providing nebulization including the steps of moving a fluid orifice or fluid pathway connected to an actuator so that the fluid orifice or fluid pathway reaches a nebulizing position during inhalation.

Abstract: An electronic cigarette comprises a main rod body with one end thereof being provided with a suction nozzle and the other end being internally provided with a battery, a one-way valve is provided in the main rod body for providing a gas passage when inhaling gas and shutting off the gas passage The one-way valve comprises a valve seat with two penetrating ends, and a valve core and a valve flap mounted inside the valve seat; the valve seat or the valve core is provided with a gas guide hole; and the valve flap is affixed to an orifice at one end of the gas guide hole and generates elastic deformation corresponding to the operation of inhaling or exhaling gas so as to control the open or closed state of the gas guide hole.

Abstract: A vent valve apparatus (10) for use with a system for supplying breathable gas pressurised above atmospheric pressure to a human or animal. The apparatus (10) includes a gas washout vent (15), a vent valve (18) adapted to progressively restrict the flow area of the washout vent (15), and a pressure sensitive vent valve control means (20,22,23). The control means is adapted to progressively cause the vent valve (18) to restrict the flow area of the gas washout vent (15) in response to increases in the pressure of the gas supply, thereby substantially regulating the volumetric flow of gas and/or CO2 gas through the washout vent (15) over a range of gas supply pressures.

Abstract: Novel nebulizers and methods are provided for a nebulizer including a dialable negative pressure threshold valve that actuates in response to different negative pressures corresponding to different negative pressure threshold settings of actuation of the valve to influence inhalation effort, aerosol entrainment, and aerosol delivery.

Abstract: An inhalation simulation system is provided for use with inhalers in particular breath-powered dry powder inhalers. The simulation system can recreate a patient's inhalation profile obtained with an inhaler adapted with a sensing and monitoring device for the detection of characteristic signals generated from the inhaler in use, which signals are transmitted to a computer with an algorithm which is configured to analyze the signals and generate new signals via a transmitter to actuate the inhalation simulation system component parts so that a subject's inhalation profile is replicated simultaneously or in real-time, or stored for later use. Methods of measuring the performance of inhalers are also provided.

Abstract: A breathing assistance apparatus includes an inner volumetric member pressurizable from a first pressure to a second pressure and an outer volumetric member surrounding at least a portion of the inner expandable volumetric member. The inner volumetric member pressurizes the outer volumetric member as the inner volumetric member is pressurized from the first pressure to the second pressure. In another embodiment, a breathing assistance apparatus includes exhalation and inhalation chambers with respective biasing members providing for the exhalation chamber to apply a pressure to the inhalation chamber and thereby provide assisted inhalation. Methods for assisting breathing are also provided.

Abstract: The invention provides storage stable sublingual formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention further provides methods for treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering the sublingual formulations of the present invention to a patient in need thereof.