Abstract: A nebulizer for a fluid, particularly for medical aerosol treatment is proposed. To allow easier operation and confer improved operational reliability a sealed container holding the fluid is already arranged in the nebulizer when it is supplied and the nebulizer is constructed so that the container is opened inside the nebulizer before or during the first use of the nebulizer. For this purpose, a transportation lock is provided for the sealed container which, in the delivery state, is in engagement with the sealed container in a manner preventing the sealed container from moving axially in the nebulizer.

Abstract: The invention relates to an inhalation therapy device with a nozzle nebuliser, in particular with a nozzle nebuliser having a nozzle element which is easy to clean and is thereby simple and reliable to handle so that the nozzle is not damaged and the geometry of the nozzle is not affected during cleaning. The aerosol generator comprises a nozzle element, said nozzle consisting of at least a first part and a second part, said first part of the nozzle element being made of a more resilient material than said second part of the nozzle element, and said first part of the nozzle element being attached to said second part of the nozzle element. Owing to the resilient material, the nozzle can deform during cleaning and can return to the original shape without altering its initial geometry.

Abstract: A nebulizer includes a body, an air channel section and medication reservoir. An air line extends through the air channel section. A venturi nozzle is configured to form at its end a low pressure mixing chamber. A primary suction line extends from the medication reservoir to the low pressure mixing chamber through which medication is drawn upward into the low pressure mixing chamber and mixed with air from the venturi nozzle and nebulized for discharge through a nebulizer outlet. The venturi nozzle, low pressure mixing chamber and air channel section are configured such that at standard temperature and pressure (STP) a differential pressure results in no medication that is drawn upward through the primary suction line for nebulization and discharged the through the nebulizer outlet until a negative inspiratory pressure is created from inhalation by a user.

Abstract: An atomizer and a method of dispensing and atomizing fluid into individual containers through a nozzle are proposed, where in order to improve the dosing accuracy, a preliminary amount of fluid, flushing the nozzle, is dispensed before each dose is dispensed.

Abstract: Particular aspects provide novel atomizers for generating particles over a broad range of MMAD size distributions, the eliminating the requirement for an impaction baffle in generating the desired particle sizes. In particular aspects, the atomization means communicates with a remote particle filter member configured and positioned to provide for particle size filtering. In additional aspects, the atomization means communicates with a particle dispersion chamber suitable to impart a desired particle flow pattern to particles within and exiting the dispersion chamber. In further aspects, the atomization means communicates with a nasal, ocular, oral or ‘vicinity’ adapter. The novel devices provide for targeted (e.g., nasal, ocular, oral, local vicinity), systemic, and/or topical delivery of an atomized liquid (e.g., via the nasal cavity, olfactory region, and mouth). Further exemplary aspects relate to aerosolization and delivery of perfume, fragrance, essential oil or cosmeceutical agents and the like.

Abstract: A device which facilitates the absorption of nicotine in order to reduce the incidence of tobacco smoking is disclosed. The device includes a tube defining an interior space. The tube has a first end with an opening and a second end. An inhalable, flowable liquid or gel composition is disposed in the interior space of the tube. The composition may include water, at least one vitamin, a flavoring agent, and nicotine. The flavoring agent may include an intense sweetener such as sucralose, and a natural or artificial fruit flavor. A user inhales on the first end of the tube of the device as a substitute oral activity to tobacco smoking and thereby ingests a source of nicotine that reduces the withdrawal symptoms experienced when smoking is stopped.

Abstract: A nebulizer includes a housing having a chamber for holding an aerosol, an air outlet communicating with the chamber for permitting the aerosol to be withdrawn from the chamber, and a reservoir for holding a liquid to be aerosolized. The nebulizer also includes a liquid orifice located in the chamber, one or more liquid channels defined between the reservoir and the liquid orifice, the one or more liquid channels having a liquid volume, and a pressurized gas outlet located in the chamber adjacent to the liquid orifice. A baffle is located in the chamber and positioned relative to the pressurized gas outlet and the liquid outlet so as to divert pressurized gas from the pressurized gas outlet and over the liquid orifice. The baffle has a diverter surface area. The liquid volume is at least 80 mm3. The diverter surface area is less than 5.0 mm2.

Abstract: An aerosol preparation assembly includes an entrainment chamber defining an entrainment volume. The entrainment chamber includes a gas inlet port, an aerosol inlet port and an outlet port. The entrainment chamber is configured such that a velocity of a flow of a gas within the entrainment volume is less than a velocity of the flow of the gas within the gas inlet port. The entrainment chamber is configured such that at least a portion of inlet aerosol is entrained into the flow of the gas within the entrainment volume to produce an entrained aerosol flow at the outlet port. The particle selection chamber is configured to receive the entrained aerosol flow and produce an outlet aerosol flow. The particle selection chamber and nozzle are collectively configured such that a volumetric median diameter of the outlet aerosol flow is less than a volumetric median diameter of the inlet aerosol.

Abstract: A nebulizer capable of supplying oxygen gas of high concentration by increasing the flow rate of the oxygen gas and capable of forming minute aerosol irrespective of a change in the flow rate of the oxygen gas. A nebulizer (A) has a nozzle member (11) for discharging oxygen gas from an orifice (11b), an aerosol forming member (12) mounted at a position corresponding to the orifice, sucking water by suction created by flow of the oxygen gas discharged from the orifice, and forming the sucked water into minute aerosol, and a window (9) and a slit (10) which suck air as the oxygen gas is discharged from the orifice of the nozzle member. The nozzle member (11) has, in addition to the orifice (11b), an oxygen gas outflow section formed in a direction different from that of the orifice and causing supplied oxygen gas to flow thereout according to the pressure of the oxygen gas.

Abstract: A nebulizer kit includes a case body, a flow channel formation member that covers an opening of the case body, an outside air introduction tube erected vertically from a base surface of the flow channel formation member and including a long groove formed in an inner circumferential surface thereof, a compressed air introduction tube below the outside air introduction tube within the case body and extending toward the interior of the outside air introduction tube, and an atomizing area formation member. The atomizing area formation member includes a liquid suction tube formation portion, a baffle, and a baffle support portion that connects the liquid suction tube formation portion and the baffle and that extends toward a side area of the baffle from an outer surface of the liquid suction tube formation portion. The baffle support portion is contained within the long groove of the outside air introduction tube.

Abstract: A system for delivering moisturizing liquid to the lips of a subject includes an applicator for applying the moisturizing liquid to the lips supported by a support structure so that at least a part of applicator is deployed so as to engage a recess between the lips of subject without obstructing contact between the subject's upper and lower lips. The proximity of the applicator to the lips allows the use of simple contact-based implementations of the applicator. At the same time, disruption of speech and other normal oral movement is minimized by avoiding any obstruction to contact between the lips.

Abstract: A nebulizer includes a body, an air channel section and medication reservoir. An air line extends through the air channel section. A venturi nozzle is configured to form at its end a low pressure mixing chamber. A primary suction line extends from the medication reservoir to the low pressure mixing chamber through which medication is drawn upward into the low pressure mixing chamber and mixed with air from the venturi nozzle and nebulized for discharge through a nebulizer outlet. The venturi nozzle, low pressure mixing chamber and air channel section are configured such that at standard temperature and pressure (STP) a differential pressure results in no medication that is drawn upward through the primary suction line for nebulization and discharged the through the nebulizer outlet until a negative inspiratory pressure is created from inhalation by a user.

Abstract: To increase the efficacy of atomizer nozzles operating with compressed gas, an atomizer device for inhalation therapy appliances includes means for delivering a compressed gas, in particular compressed air; means for supplying a fluid that is to be atomized, in particular a therapeutic liquid; several compressed gas outlet openings from which a delivered compressed gas emerges; and several fluid outlet openings from which the fluid to be atomized emerges on account of the emerging compressed gas. The atomizer device includes at least three compressed gas outlet openings arranged in a row, and one of the compressed gas outlet openings is in each case assigned at least two fluid outlet openings which, together with the associated compressed gas outlet opening, form an atomizer nozzle.

Abstract: A fluid sample dispenser includes a microdosing device for outputting, during an activation state, a fluid sample at a fluid sample outlet to the environment, wherein the microdosing device is placeable adjacent to a person's nose so that a distance between the outlet of the microdosing device and a nostril of the person's nose is within a predefined range, and a microdosing driver unit for adjusting a dosing rate of the scent sample output at the scent sample outlet by selectively activating the microdosing device.

Abstract: Methods, devices and compositions for treatment of severe and uncontrolled asthma are provided by which high amounts of an inhaled corticosteroid are directed to the small airways of the lower lungs. The invention provides for a substantial decrease in the dose of concurrently administered oral corticosteroids. A particular advantage of the invention is the significant reduction in corticosteroid-related adverse effects.

Abstract: A medical atomizer includes a liquid storage container, a nozzle and an adjustable valve. The liquid storage container includes an air inlet, a fixed cover plate installed at the periphery of the air inlet, and a high pressure jet installed at the bottom of the liquid storage container. The nozzle is installed in the liquid storage container and covered onto the high pressure jet. The adjustable valve is interconnected to the air inlet and has a port selectively adjusted and moved to be covered by fixed cover plate. With the fixed cover plate of the air inlet, the air inlet can be selectively adjusted and moved to change the size of the port to be covered by the fixed cover plate, so as to adjust the flow of air entering into the air inlet.

Abstract: The present invention is to provide a gas mist inhaler making use of physiological actions of carbon dioxide or oxygen, which is simple in a structure and excellent in effects.

Abstract: A device which facilitates the absorption of nicotine in order to reduce the incidence of tobacco smoking is disclosed. The device includes a tube defining an interior space. The tube has a first end with an opening and a second end. An inhalable, flowable liquid or gel composition is disposed in the interior space of the tube. The composition may include water, at least one vitamin, a flavoring agent, and nicotine. The flavoring agent may include an intense sweetener such as sucralose, and a natural or artificial fruit flavor. A user inhales on the first end of the tube of the device as a substitute oral activity to tobacco smoking and thereby ingests a source of nicotine that reduces the withdrawal symptoms experienced when smoking is stopped.

Abstract: A nebulizer for a fluid, particularly for medical aerosol treatment is proposed. To allow easier operation and confer improved operational reliability a sealed container holding the fluid is already arranged in the nebulizer when it is supplied and the nebulizer is constructed so that the container is opened inside the nebulizer before or during the first use of the nebulizer. Alternatively, or in addition, the nebulizer is constructed so that the container cannot be replaced, and in particular, cannot be removed.

Abstract: The invention relates to a small-volume nebulizer with a valve system to provide lung physiotherapy during airway therapy with small-volume nebulizers. The valve system may be incorporated into a small-volume nebulizer. The small-volume nebulizer may be pre-filled with at least one unit-dose of medicine and hermetically sealed until use. The nebulizer may be sealed at the top with a removable cap that may be detached at the time of use and replaced with a patient connector. Likewise, the nebulizer may be sealed at the bottom with a bottom cap that is replaced with a gas source at the beginning of a therapeutic aerosol treatment.

Abstract: A nebulizer kit includes a case body, a flow channel formation member that covers an opening in an upper area of the case body, and a cylindrical aerosol discharge port that passes through a portion of the top surface of the flow channel formation member located toward the outer edge thereof. The case body and/or the flow channel formation member includes a rotation mechanism that, when the case body has overturned and the aerosol discharge port has become positioned on the lower side in the vertical direction of the top surface of the flow channel formation member, causes the case body to rotate in a circumferential direction to cause the aerosol discharge port to move away from a lower side in the vertical direction. Even if the nebulizer kit has overturned, a liquid within the nebulizer kit is prevented from spilling.

Abstract: A nebulizer system includes a bottle that has a bottle mouth on top thereof and stores liquid therein, a heater device that is connectable to the bottle mouth, and a nebulizer adapter that is connectable to the heater device. The bottle includes a dip tube that is dipped into the liquid stored therein. An upper end portion of the dip tube is disposed inside a circumferential wall of the bottle mouth with a clearance communicating between an interior and an exterior of the bottle via the bottle mouth. The nebulizer adapter includes a nozzle member that has an orifice for injecting gas, and an aerosol-forming member in a corresponding position with the orifice, the aerosol-forming member sucking up the liquid in the bottle via the dip tube and heater device by a stream of gas injected from the orifice, and generating fine aerosol from the sucked liquid.

Abstract: The present invention is directed generally to a nebulizer for the formation of micro-droplets from liquid medicaments for respiratory patient treatment, and more specifically, to a baffled nebulizer wherein a static baffle used to form an atomized medicament is proximal to a shied which responds to patient respiration force to oscillate from an aerosol flow occluding position to an aerosol flow open position. During inhalation, the shield moves into a first registration format to allow passage of the atomized medicament (nebula) to the patient. During exhalation/non-use, a biasing pressure maintains said shield in a second registration format such that the nebula is retarded from passing to the patient and is coalesced into macro-droplets which return to a supply reservoir for re-atomization.

Abstract: The inhalation nebulizer according to the invention has a liquid reservoir, whose surface facing the liquid to be nebulized has a surface structure comprising protrusions and indentations, of which at least the protrusions consist of hydrophobic materials or permanently hydrophobized materials.

Abstract: The invention provides compositions and methods for the prophylaxis or treatment of diseases or disorders in a subject (e.g., a mammal, such as a human) including, e.g., diseases or disorders caused by biological agents, autoimmune diseases, and cancer. The compositions include a delivery vector (e.g., a viral vector, such as an Ad5 vector) encoding an interferon (e.g., IFN-?), and are provided to the subject by, e.g., intranasal or pulmonary administration.

Abstract: The present invention includes a method for delivering medications deeper into the lungs and to the medications' pulmonary targets, which include bronchioles and alveoli. A first particularly preferred embodiment of the invention describes the use of two steps for delivery of a medication. In a first step, an aerosolized therapeutic composition or medication is administered into a patient's respiratory tract, wherein the patient may be any animal or human subject. Following the first step, an aerosolized surfactant is administered into the patient's respiratory tract that facilitates delivery of the aerosolized medication of the first step to the medication's pulmonary target. Another embodiment of the present invention contemplates an apparatus for the delivery of an aerosolized surfactant used that facilitates delivery of previously inhaled aerosolized medication.

Abstract: A dosing device can be activated by a vacuum air stream of a user for the inhalation of a powder substance, particularly medicine, which is arranged in a supply chamber and which can be brought out of the same into an open emptying-ready position by a dosing chamber of a dosing rod when the mouthpiece-closure cap is removed. In particular, in order to improve dispensing, the provision of two air paths, of which one serves to open and empty the dosing chamber, and/or the second air path penetrates directly into a ring chamber in order to mix with the air flow containing the substance.

Abstract: Discharge device for nasal application of medicaments. The invention relates to a discharge device (10) for nasal application of medicaments, with a main body (A) having a contact surface (10b) which, during use, is vertically oriented and is directed toward the face of the user, and with a nosepiece (70) which is arranged in a fixed position with respect to the main body (A) and is designed to be inserted into a nostril of the user, which nosepiece (70) is provided on an upper edge area of the contact surface (10b), protrudes from the contact surface (10b) and has a discharge opening (72). Use as a discharge device that counteracts incorrect use.

Abstract: An anesthesia system is provided including an anesthesia apparatus, an anesthetic dispenser with an anesthetic reservoir, at least one dispensing parameter detection means, a contactless interface between the anesthesia apparatus and the anesthetic dispenser for transmitting data, especially the dispensing parameters, and for supplying the at least one dispensing parameter detection means with energy. The data and energy transmission takes place by means of electromagnetic field forces.

Abstract: An inhaler is proposed having an insertable container and a monitoring device for counting uses of the inhaler. The monitoring device is arranged in a detachable housing part or fitted onto a mouthpiece of the inhaler. A supply air current is detected by means of a pressure sensor. A position sensor may further be provided.

Abstract: Disclosed is a nebuliser (1) and a housing part (18) removably connected thereto, each having a coding (25, 26. To increase the flexibility in the coding while using carry-over parts at least one of the coding means (25, 26) can be mounted in different defined positions on the nebuliser (1) or the housing part (18) removably connected thereto so that in each position a different coding is obtained in which the coding means (25, 26) match one another.

Abstract: A nebulizer (10) includes a housing (12) having an inlet (18), a compressor (28), a reservoir (58) and a nozzle assembly (56) disposed therein. The compressor includes a number of rotor members (30), each rotor member being rotatable about a respective axis (32) with each respective axis being parallel with every other respective axis and spaced an equal distance (r) from a central axis (34) of the compressor. The compressor further includes a compression chamber (36) and a motor(38). The compression chamber has a variable volume defined by the relative positioning of the number of rotor members. The compression chamber is in selective fluid communication with the inlet. The motor has an output shaft (40) operatively coupled to the number of rotor members in a manner such that rotation of the output shaft causes rotation of each rotor member of the number of rotor members. The motor is adapted to be coupled to a power source. The reservoir is adapted to receive a quantity of medication (60).

Abstract: Various aspects described herein are directed to nebulizer assemblies for improving the effectiveness of the nebulizers. In some embodiments, instead of placing a nebulizer directly in-line with a first passageway connecting between a patient connector and a ventilator, nebulizer assemblies, in which the nebulizer is connected to a second passageway that extends upward from a top portion of the first passageway, are provided herein. Such configuration of the nebulizer assemblies can prevent a patient's secretion from clogging the nebulizer and thus improve the output of a drug delivered to the patient.

Abstract: In a method of producing trench-like depressions (24) in the surface of a wafer (27), particularly a silicon wafer, by plasma etching, in which the depressions (24) are produced by alternate passivation and etching, each depression (24) in its final geometry is provided with a protective layer (30) of the polytetrafluoroethylene type.

Abstract: A nebulizer for efficiently and reliably delivering aerosolized fluid to an inhaling patient is disclosed. The nebulizer includes a fluid channel air inlet and fluid channel air inlet valve responsive to either a manual force external of the nebulizer, or a patient's breathing, to begin the nebulization process. Also provided is a method of providing nebulization including the steps of moving a fluid channel air inlet valve against a fluid channel air inlet so that a negative pressure may build up over the fluid in the fluid channel to draw fluid from the fluid reservoir and begin nebulization during inhalation.

Abstract: Nasal formulations of metoclopramide, which remain stable and/or colorless upon storage over a period of time, are provided. Also provided are methods of treating disorders treatable with metoclopramide, comprising administering the nasal solutions to patients in need thereof.

Abstract: A passive inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. The inhaler has a flow resistance of at least 75000 Pa1/2s/m3.

Abstract: A nebulizer (1), in particular inhaler, having a pre-installed container (3) is proposed. The nebulizer comprises a securing member (30) preventing fluidic connection or opening of the container in a delivery state. The securing member can be manually opened, removed, released or destroyed by torsioning, by opening along a pre-determined breaking line and/or by means of an actuator (50). This facilitates handling.

Abstract: Proposed are a medical spray head (300) for spraying one or more fluid substances with the use of a compressed gas, a spray device equipped therewith, and a method for using the same. In order to avoid too high a gas pressure, the spray head comprises a pressure relief valve (310) which guides the compressed gas out of the spray head if the gas pressure exceeds a threshold pressure. As a result, the risk of gas embolisms occurring during the use of such a spray head for medical purposes is reduced.

Abstract: A nebulizer includes an air channel section and medication reservoir. An air line extends through the air channel section. A venturi nozzle is at its end and configured to form a low pressure mixing chamber. A vent is formed in the body and communicates with the air channel section and medication reservoir to vent the air channel section and medication reservoir to outside ambient air. A primary suction line extends from the medication reservoir to the low pressure mixing chamber through which medication is drawn upward and mixed with air passing through the venturi nozzle and nebulized for discharge. The vent is configured to vent the air channel section and medication reservoir to atmospheric pressure such that at standard temperature and pressure (STP), a differential pressure results between the venturi nozzle and medication reservoir such that no medication is drawn upward through the primary suction line.

Abstract: Disclosed herein are vials and devices containing a ketorolac solution for intranasal administration and a head space comprising no more than about 10% v/v oxygen and which vials and devices are stored in an oxygen-impermeable pouch. Also disclosed are processes for preparing the vials and devices.

Abstract: A hot air extraction vaporizer that is provided with a heat exchanger, a filling chamber for accommodating a substance generating an aerosol when subjected to heat, and a vaporizer outlet for inhaling the aerosol/air mixture. The heat exchanger is in a thermally conductive connection with the filling chamber that when heated up subjects the substance to radiant heat. The heat exchanger is provided with at least one airflow channel generating a hot airflow. The filling chamber comprises at least one of airflow passages and a mesh allowing the hot airflow to pass through the filling chamber and the substance provided therein.

Abstract: Systems and methods for neutralizing a solution comprising a compound of interest, comprising: aerosolizing a solution, wherein the solution is a low pH solution and comprises the compound of interest; contacting the aerosolized solution with ammonia vapor, wherein the ammonia vapor neutralizes at least a portion of said aerosolized solution; and removing at least some water from the neutralized aerosolized solution, wherein the neutralized aerosolized solution is at least partially dehydrated.

Abstract: A discharge head 10 (in illustrated embodiments) for discharging droplets from discharge ports can withstand high water pressure and is provided with a first orifice plate 3 having first discharge ports 3a and a second orifice plate 6 having second discharge ports. The first orifice plate 3 and the second orifice plate 6 are separated from each other in the liquid discharge direction of the discharge head 10 and disposed opposite to each other. The diameter of the discharge ports of the second orifice plate 6 is smaller than the diameter of the discharge ports 3a of the first orifice plate 3 so that very fine droplets 9 are discharged from the discharge head 10 as the liquid discharged from the discharge ports 3a of the first orifice plate 3 is split by the second discharge ports.

Abstract: A nebulizer is proposed which comprises a replaceable container containing fluid, a housing part detachable from the nebulizer for replacing the container, and an operation counter inseparable from the housing part as depicted in exemplary FIG. 10. The operation counter comprises a lead screw and an associated rider both supported by the housing part.

Abstract: A nebulizer is proposed as depicted in exemplary FIG. 7 which comprises a replaceable container, a counting device and a lock for locking the nebulizer against further use. The container is provided with an electronic storage which is electrically connected to the counting device. The nebulizer comprises an electric drive for actuating the lock. This allows secure operation and/or simple handling of the nebulizer.

Abstract: An improved tee type nebulizer unit for medicinal use that delivers a mist of properly sized aerosol particles of medicament to the patient. A uniquely configured air flow baffle assembly, which is strategically positioned within the tee of the nebulizer unit, markedly increases the rate of liquid-to-aerosol conversion compared to prior art tee type nebulizer units. More particularly, due to the positioning and sizing of the air channeling pathways within the air flow baffle assembly, an increase in rate of aerosol mist production by factors of 200%-300% is realized.

Abstract: Dispensing apparatus for delivering metered doses of product from a pressurized dispensing container, having a housing for receiving, in use, the pressurized dispensing container, and an outlet through which, in use, metered doses of product from the pressurized dispensing container can be dispensed. The housing has an aperture via which the pressurized dispensing container can be inserted into the housing. The dispensing apparatus is at least partially enclosed by a shrink wrapped film, the shrink wrapped film including an opening which is: (a) at least partly aligned with the aperture of the housing; and (b) dimensioned so as to allow, in use, said pressurized dispensing container to pass through the opening in order to be inserted into the housing via the aperture.

Abstract: A flow generator for delivering breathable gas to a patient includes a processor coupled with operation sensors and a user interface. The processor is programmed to generate at least one of time-based or event-based messages relating to at least one of flow generator operation, flow generator service, flow generator use, patient health, peripheral devices and services, patient treatment, and reminders. Time-based messages are generated at predetermined time intervals based on either time of use or elapsed time. The event-based messages are generated based on signals from the operation sensors. The user interface is configured to deliver the messages to at least one of a display, a flow generator service provider, the patient and a physician. By this system, operation of the flow generator is facilitated and enhanced.

Abstract: A supplemental oxygen delivery system is described in which Aerosol is delivered into a housing 10, 20, which sits in the circuit from the supplemental oxygen supply and optional humidifier. The supplemental oxygen passes through this chamber 10, 20 in which the aerosol is located, and collects the aerosol transporting it to a patient via a nasal cannula 3 or a face mask 4. An aerosol generator 9 is mounted to the housing 10, 20 and delivers aerosol into an oxygen stream 13 flowing between an inlet 14 and an outlet 15 of the housing 10. The housing 10 also has a removable plug 16 in the base 17 thereof for draining any liquid that accumulates in the housing 10. There is no disruption of oxygen delivery to patients using nasal cannulas who currently have to use a separate face-mask when receiving nebulized medication.