Particulate Treating Agent Carried By Breathed Gas Patents (Class 128/203.15)
-
Publication number: 20130306069Abstract: The invention relates to a method of delivering an agent to the pulmonary system of a compromised patient, in a single breath-activated step, comprising administering a particle mass comprising an agent from an inhaler containing less than 5 milligrams of the mass, wherein at least about 50% of the mass in the receptacle is delivered to the pulmonary system of a patient. The invention also relates to receptacles containing the particle mass and the inhaler for use therein.Type: ApplicationFiled: May 2, 2013Publication date: November 21, 2013Applicant: Civitas Therapeutics, Inc.Inventor: Jeffrey S. Hrkach
-
DEVICE FOR DISPENSING A PLURALITY OF UNITARY DOSES OF DRY POWDER, AND INHALER COMPRISING SUCH DEVICE
Publication number: 20130306071Abstract: Various embodiments relate to a device for dispensing a plurality of unitary doses of dry powder. The device includes: a casing; first and second supports respectively for two carriers each having a plurality of housings for respective unitary doses adapted to be connected to the mouthpiece for inhalation of the dose, the first and second supports being moveably mounted within the casing for sequentially connecting the housings to the mouthpiece; an indexing mechanism adapted to engage and move the first and second supports; and a changeover mechanism adapted to cause the device to pass from a first dispensing state to a second dispensing state and lock the second support in its stationary position while the device is in the first dispensing state, and to lock the first support in its stationary position while the device is in the second dispensing state.Type: ApplicationFiled: July 26, 2013Publication date: November 21, 2013Applicant: Pfizer LimitedInventors: Louise Annabel BUNCH, Paul George Harris -
Patent number: 8578932Abstract: A Breath Actuated Inhaler having a canister with a medication dispensed when compressing the canister. Compression of the canister is prevented by a mechanism only allowing compression when an air flow is sufficient to ensure dispensing of the medication in the lungs/throat of the person. No latch or blocking mechanism is provided so that any force exerted by the person is, at all times, directed to the canister or preventing mechanism so that when no force is exerted by the user, no force is exerted in the inhaler. Prolonged exertion of such force could otherwise cause dimension changes and subsequent uncertainty of the dose size.Type: GrantFiled: June 30, 2009Date of Patent: November 12, 2013Assignee: Bang & Olufsen Medicom A/SInventors: Bjørn Knud Andersen, Søren Christrup, Jørgen Rasmussen
-
Patent number: 8578933Abstract: A device for inhalation of at least one air stream carrying a dose of medicament powder. The device comprises a powder-containing cavity which opens into a flow passage. The flow passage is arranged to direct an inhalation air flow across the cavity opening. A circulating flow is thereby induced in the cavity by the phenomenon of shear driven cavity flow. Powder is entrained in the circulating flow and deaggregated before exiting the cavity and becoming entrained in the flow of air along the flow passage.Type: GrantFiled: July 1, 2009Date of Patent: November 12, 2013Assignee: AstraZeneca ABInventors: Johan Remmelgas, Per Arne Kjellgren, Orest Lastow, Mårten Svensson
-
Publication number: 20130291867Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation.Type: ApplicationFiled: July 2, 2013Publication date: November 7, 2013Inventors: Chad C. Smutney, Benoit Adamo, John M. Polidoro, P. Spencer Kinsey, Dennis Overfield, Carl R. Sahi, Christine Billings, Mark T. Marino
-
Publication number: 20130291866Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin, oxyntomodulin and glucagon-like peptide.Type: ApplicationFiled: July 2, 2013Publication date: November 7, 2013Inventors: Chad C. Smutney, P. Spencer Kinsey, Carl R. Sahi, Benoit Adamo, John M. Polidoro, Scott McLean, Dennis Overfiled, Anthony Bryant
-
Publication number: 20130291865Abstract: A dose delivery device includes a mouthpiece having an inlet and an outlet, a dose to be delivered to a subject via the mouthpiece and a housing surrounding the mouthpiece and the dose. The mouthpiece or other portion of the device may be moveable to form an opening in the housing, open a dose chamber and/or to extend the mouthpiece from the housing for delivery of the dose. The mouthpiece and housing may be arranged so that the mouthpiece remains attached to the housing after the opening is formed and the mouthpiece is extended from the housing. The housing may include a layer of barrier material that interacts with the mouthpiece to form the opening, e.g., the mouthpiece and barrier material may be moved relative to each other so that the barrier material is pierced. A dose chamber may be formed by a portion of the housing, a portion of the mouthpiece, and/or by any other suitable component of the delivery device.Type: ApplicationFiled: May 3, 2013Publication date: November 7, 2013Inventors: Andrew Jones, Richard L. Miller
-
Patent number: 8573197Abstract: Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.Type: GrantFiled: October 25, 2007Date of Patent: November 5, 2013Assignee: Novartis AGInventors: George S Axford, Mark Glusker, William W Alston, John Palmer-Felgate, Jonathan Wilkins, Willard R Foss, Nagaraja Rao, Mark Postich, Neeraj R Pakala, David S Maltz, Keith Ung
-
Patent number: 8573202Abstract: A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.Type: GrantFiled: August 17, 2010Date of Patent: November 5, 2013Assignee: Microdose Therapeutx, Inc.Inventor: Anand V. Gumaste
-
Patent number: 8573204Abstract: A dosing device can be activated by a vacuum air stream of a user for the inhalation of a powder substance, particularly medicine, which is arranged in a supply chamber and which can be brought out of the same into an open emptying-ready position by a dosing chamber of a dosing rod when the mouthpiece-closure cap is removed. In particular, in order to improve dispensing, the provision of two air paths, of which one serves to open and empty the dosing chamber, and/or the second air path penetrates directly into a ring chamber in order to mix with the air flow containing the substance.Type: GrantFiled: October 29, 2008Date of Patent: November 5, 2013Assignee: Siegfried Generics InternationalInventors: Alfred Von Schuckmann, Yorick Kamlag, Stefan Mayer, Dennis Sandell
-
Patent number: 8567394Abstract: To provide an inhalation device which has improved use properties, particularly advanced moisture protection while in use, an inhalation device (1) for powder drugs is proposed comprising at least one storage chamber (13) for accommodating a plurality of drug powder doses and a dosing device which includes at least one dosing slider (15) which is movable approximately with a translatory movement in a dosing slider passage (16) at least from a filling position into an emptying position, wherein the inhalation device (1) further includes a device for inhalation-triggered automatic movement of the dosing slider (15) from its filling position into the emptying position and a return device for automatic movement of the dosing slider (15) back into the filling position.Type: GrantFiled: December 21, 2007Date of Patent: October 29, 2013Assignee: Almirall, S.A.Inventors: Martin Herder, Gerhard Ludanek, Ingo Mett
-
Publication number: 20130276783Abstract: A filtering powdered medicament inhaler comprising a base (1) and an upper base (2). The upper base (2) has arranged therein a separator (62), which is connected at the bottom to a pressure groove (63). The upper base (2) has arranged thereon a hollow tube exterior connector (10) matching a suction tube (131). The hollow tube (19a) and a cavity (9) on one side of the separator (62) are interconnected via conduit (18), or, the hollow tube (19a) is extended for about 8 centimeters to form a mouthpiece. The upper base (2) has arranged in the cavity (9) thereof a filter (121). The base (1) is provided with an external base cover (72) which covers a press-button (5a) so as to reduce air flow into the cavity (9). The medicament inhaling conduit of the inhaler is relatively sealed and allows for rapid entrainment of a sufficient dosage of powdered medicament.Type: ApplicationFiled: December 15, 2011Publication date: October 24, 2013Inventors: Qingtang Chen, Xin Chen
-
Patent number: 8561609Abstract: A dry powder inhaler includes a chamber holding an actuator to which a powdered medicament is adhered. Air is drawn into the chamber through an inlet flow channel and exits through an outlet flow channel. The actuator oscillates in response to the air flow, dislodging powdered medicament to be entrained in the air flow and delivered to the patient. A retaining member prevents the actuator from exiting the chamber. Thus, the medicament may be delivered to the patient without the use of carrier particles.Type: GrantFiled: December 7, 2011Date of Patent: October 22, 2013Assignee: Respira Therapeutics, Inc.Inventors: Martin Donovan, Jacques Pappo, Hugh Smyth
-
Patent number: 8561608Abstract: An inhaler device having an opening device for opening an individual reservoir containing a single dose of fluid, such as powder, the reservoir including a closure wall, the opening device having hollow perforator mechanism that is adapted to perforate the closure wall of the reservoir, the hollow perforator mechanism being connected to an expulsion channel so as to transport the powder towards a dispenser orifice of the inhaler. The opening device includes at least one air channel connected to the expulsion channel, such that during inhalation, an air flow passing through the at least one air channel mixes, in the expulsion channel, with the air and powder flow leaving the reservoir through the hollow perforator mechanism. The air channel is formed by a through hole made in a wall of the perforator mechanism, the through hole being oriented substantially parallel to the expulsion channel.Type: GrantFiled: July 1, 2008Date of Patent: October 22, 2013Assignee: Aptar France SASInventor: David Chopard
-
Patent number: 8561610Abstract: A medicament dispensing device, a medicament magazine thereof, and a method of removing a medicament from the medicament magazine. The inhaler has a mouthpiece (9) and an air channel (4) connected thereto, as well as a medicament magazine with at least one medicament chamber containing a powdered medicament. A drive current is produced in the air channel, while a vacuum flow (5?) can be produced by the drive current and a constriction formed in the air channel. This narrowest part of the air channel that produces the vacuum flow is connected to a removal opening (2) which communicates with a control opening (3), in order to form an emptying current through the control opening via the removal opening. In a preferred embodiment the at least one medicament chamber including the control opening, the removal opening and a fill opening are housing in the one-piece medicament magazine.Type: GrantFiled: May 29, 2012Date of Patent: October 22, 2013Assignee: Boehringer Ingelheim International GmbHInventors: Herbert Wachtel, Johannes Geser, Burkhard Metzger, Michael Spallek, Michael Krueger, Hubert Kunze, Achim Moser, Elmar Mock, Antonino Lanci, Andre Klopfenstein
-
Patent number: 8561606Abstract: A heat and moisture exchange unit for use with a patient breathing circuit. The unit includes a housing, an MDI port assembly and a heat and moisturizing medium. The housing forms a patient-side port, a ventilator-side port, and a containment region between the patient-side port and the ventilator-side port. The MDI port assembly includes a frame projecting into the containment region and configured to receive a portion of a metered dose dispenser. The frame terminates at an outlet end, forming a flow passage. The heat and moisturizing medium is maintained within the containment region so as to define a medium face most proximate the outlet end of the MDI port assembly. The unit is characterized by the absence of a body between the outlet end and the medium face.Type: GrantFiled: June 5, 2008Date of Patent: October 22, 2013Assignee: CareFusion 2200, Inc.Inventor: Neil Alex Korneff
-
Publication number: 20130269695Abstract: A dry-powder inhaler (100; 200) comprising: a body (110; 210) forming a dispersion chamber (111; 211); a dispenser orifice (131; 231) through which the user inhales; a loading opening (121; 220) that receives a capsule (10) containing a dose of dry powder for inhaling; and capsule opening means (140; 265) for opening a capsule inserted into said loading opening and emptying said dose of powder into said dispersion chamber; said body (110; 210), at least at one wall of said dispersion chamber, being made of a tinted transparent material that is adapted to filter UV rays, at least in part, and to make it possible to see the inside of the dispersion chamber while masking, at least in part, residues of powder that are stuck to said at least one wall of tinted transparent material.Type: ApplicationFiled: December 12, 2011Publication date: October 17, 2013Applicant: APTAR FRANCE SASInventors: Guillaume Brouet, Zakaria Sallak
-
Patent number: 8555878Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.Type: GrantFiled: June 2, 2006Date of Patent: October 15, 2013Assignee: OptiNose ASInventor: Per Gisle Djupesland
-
Patent number: 8555877Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.Type: GrantFiled: June 2, 2006Date of Patent: October 15, 2013Assignee: OptiNose ASInventor: Per Gisle Djupesland
-
Patent number: 8555873Abstract: A system and a method for studying or predicting the interaction between a lung and an aerosolized agent. The system comprises an aerosol generator (10) sealingly connected to an exposure arrangement adapted to provide a transport aerosol flow from an aerosol holding chamber of the aerosol generator (10) to a flow junction; and an exposure aerosol flow from the flow junction for distribution to an exposure organ with breathing capacity thereby a providing a residual aerosol flow transported away from the flow junction. The exposure arrangement further comprises a flow rate monitoring device located upstream the flow junction for monitoring the transport aerosol flow, a device for measuring the aerosol particle concentration located downstream the flow rate monitoring device, and optionally a flow control function for controlling the transport aerosol flow. Using the system for predicting the interaction between a lung and an aerosolized agent minimizes the loss of the agent.Type: GrantFiled: June 27, 2008Date of Patent: October 15, 2013Assignee: Inhalation Sciences Sweden ABInventor: Per Gerde
-
Patent number: 8555876Abstract: The invention provides a fail-safe module (FSM) integral with a sedation and analgesia system that meets the high-reliability needs of sedation and/or analgesia delivered by non-anesthetist practitioners. The FSM may operate in “real-time” in order to ensure optimal patient safety. The FSM may deactivate specific patient interfaces, user interfaces, and/or sedation and analgesia delivery in order to ensure patient safety and has redundant safety systems in order to provide the fail-safe module with an accurate assessment of controller functionality.Type: GrantFiled: April 17, 2009Date of Patent: October 15, 2013Assignee: Scott Laboratories, Inc.Inventors: Randall S. Hickle, Jason Derouen
-
Patent number: 8550071Abstract: Dry powder inhalers include radially-extending discrete, typically dose-specific, airway channels serially forming a portion of the inhalation pathway to deliver dry powder to a user using the inhalers.Type: GrantFiled: September 25, 2009Date of Patent: October 8, 2013Assignee: Oriel Therapeutics, Inc.Inventors: Rachel Striebig, Matthew Allen, Thomas W. Ruckdeschel, Charles A. Buckner, III, David Harris, Scott Alexander Lewis, Andrew Murray Gow, Jonathan David Tuckwell
-
Patent number: 8550070Abstract: An inhaler device includes an air conduit including a mouthpiece and a dosing means adapted to provide a dose of powder to the air conduit for entrainment in the stream of air. In the area downstream from the dosing means the wall of the air conduit is provided with a secondary air inlet extending to the direction of the mouthpiece such that the entry of secondary air occurs over an extended length of the air conduit downstream from the dosing means.Type: GrantFiled: June 20, 2002Date of Patent: October 8, 2013Assignee: Orion CorporationInventors: Kari Seppälä, Terhi Mattila, Kalle Purma, Markku Härkönen
-
Patent number: 8550069Abstract: An apparatus including a first cartridge, a sensor, and a controller. The first cartridge can include a first release device configured to release a first substance into a housing. The controller can be configured to receive data from the sensor. The controller can determine an amount of first substance released by the first cartridge based on the data. The first release device can be controlled based on the determined amount of first substance.Type: GrantFiled: August 23, 2011Date of Patent: October 8, 2013Inventor: Eli Alelov
-
Patent number: 8550076Abstract: An ambient or room air vacuum attachment or nozzle is provided proximal to the connection between a breathing circuit and the protruding inlet port of a respiratory face mask, and a tubular passageway is sealingly connected between the vacuum attachment or nozzle and a source of vacuum. By virtue of such structure, any gas escaping from the periphery of the respiratory face mask through accident or otherwise is immediately and automatically “vacuumed-up” by the proximally located vacuum attachment or nozzle and evacuated from the surrounding room environment through the vacuum source to which the ambient air vacuum nozzle and tubular passageway are connected.Type: GrantFiled: May 19, 2010Date of Patent: October 8, 2013Inventor: Ramses Nashed
-
Patent number: 8550067Abstract: A delivery system includes a holding chamber with first, second and third openings, and independently moveable first, second and third flow control members. A delivery system includes a holding chamber and a flow control member including a flap pivotable from an at rest position in a direction toward an outlet of a user interface and away from an output end of the holding chamber in response to a pressure being applied thereto.Type: GrantFiled: December 7, 2011Date of Patent: October 8, 2013Assignee: Trudell Medical InternationalInventors: Sarah Bruce, James N. Schmidt
-
Publication number: 20130255678Abstract: An inhaler for dispensing a pharmaceutical to infants and respiratory compromised patients is disclosed.Type: ApplicationFiled: March 14, 2013Publication date: October 3, 2013Inventors: Anand Gumaste, Scott Fleming, Philip Chan
-
Publication number: 20130255679Abstract: An inhalator for the inhalation of powdered drug preparations from capsules which contain the powdered preparations. The inhalator has a mouthpiece or nosepiece and an assembly including: a capsule holder including a capsule chamber, the capsule chamber having an air inlet opening and an air outlet opening; a capsule opening device for opening a capsule; a finger-operable actuator. The inhalator further includes a rigid outer shell including a lower shell part hinged to an upper shell part so that the shell is openable and closable, the shell serving to cover and protect the assembly and the mouthpiece or nosepiece.Type: ApplicationFiled: December 5, 2011Publication date: October 3, 2013Applicant: LABORATORIOS LICONSA, S.A.Inventors: Laura Andrade, Jose Ramon Ruiz, Celestino Ronchi, Alessandro Castellucci
-
Patent number: 8539946Abstract: The invention relates to a dry powder inhaler, having a base housing, having a capsule receptacle for a capsule containing dry powder, having at least one needle- or blade-like opening means, movably arranged in relation to the base housing, for opening the capsule, and having a mouthpiece, through which the dry powder from an opened capsule can be inhaled. The invention is distinguished in that the opening means are fastened on the mouthpiece, and that the mouthpiece can be moved in respect to the base housing out of a normal position into an opening position which opens the capsule.Type: GrantFiled: February 19, 2007Date of Patent: September 24, 2013Inventors: Victor Esteve, Achim Kreim
-
Patent number: 8539947Abstract: An inhaler for inhaling powdered medicaments from capsules, having: a lower part which is cup-shaped, a plate latched to the lower part to close off the lower part, a capsule holder arranged on the underside of the plate, a mouthpiece that can be latched to the top of plate, and an actuating member for interacting with at least one pin for piercing a capsule in the capsule holder, where the actuating member includes a larger outer actuating member and a smaller inner actuating member, the outer actuating member forms a user-operated push-button, the inner actuating member contacts and holds the pin below a suspension element of the outer actuating member from the plate, and the point of application of force by the user onto push-button is lower than the inner actuating member.Type: GrantFiled: July 17, 2008Date of Patent: September 24, 2013Assignee: Boehringer Ingelheim International GmbHInventors: Rolf Kuhn, Burkhard Peter Metzger, Torsten Kuehn, Heinrich Kladders, Joern-Eric Schulz
-
Patent number: 8539945Abstract: A dose counter for a metered dose inhaler includes a force sensor, an electronic controller, a memory for storing data indicative of a remaining number of doses and an electronic display device coupled to the controller for displaying the remaining number of doses. The dose counter is attached or integrated into a base of a canister containing medicament such that force applied to the base of the canister is registered by the force sensor, the controller being configured to measure force applied to the dose counter when depressing the canister and being responsive to measured force to decrement the remaining number of doses stored in the memory and shown on the display device.Type: GrantFiled: August 12, 2010Date of Patent: September 24, 2013Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Ian Solomon, Moti Goldhirsh
-
Patent number: 8534280Abstract: A device for use in an aerosol inhalation system for delivering aerosolized medication includes a housing that is operatively connected to a source of aerosolized medication such that the aerosolized medication is delivered to the housing. The device also includes a patient interface member removably connected to the housing and being separate therefrom. The patient interface member is in the form of a face mask for placement about a face of the patient and in communication with a mouth of the patient for delivering the aerosolized medication. The patient interface member incorporates an integral inhalation valve and safety feature for protecting against displacement of the inhaltation valve.Type: GrantFiled: November 19, 2007Date of Patent: September 17, 2013Assignee: Aeon Research and Technolgy Inc.Inventors: Sunil Kumar Dhuper, Herbert Fred D'Alo
-
Patent number: 8534281Abstract: A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack comprises a body, the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from said chimney inlet to the chimney exit; the body further defining a chamber having a chamber inlet and a chamber exit, wherein the chimney exit and the chamber inlet lie side-by-side each other such that when the open blister pocket of the blister pack is positioned adjacent thereto the airflow is directed from the chimney exit to the chamber inlet via the open blister pocket to entrain the medicament powder and enable transport thereof in the airflow from the chamber inlet to the chamber exit, and wherein one or more bleed holes are provided between the chimney and the chamber such that bleed airflow is able to be directed into the chamber to disruptively impact the airflow that transports the entrained medicament powder.Type: GrantFiled: December 11, 2006Date of Patent: September 17, 2013Assignee: Glaxo Group LimitedInventors: Michael Birsha Davies, Mark Andrew Hailey, Mark Gregory Palmer, Richard Ian Walker
-
Publication number: 20130233313Abstract: A medicated module containing a second medicament is configured for removable attachment to the mouthpiece of an inhaler containing a first medicament such that a single inhalation by a user will deliver both medicaments to the user.Type: ApplicationFiled: November 28, 2011Publication date: September 12, 2013Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Alasdair George Young, Daniel Thomas De Sausmarez Lintell, David Richard Mercer
-
Device for dispensing a plurality of unitary doses of dry powder, and inhaler comprising such device
Patent number: 8528549Abstract: A device for dispensing a plurality of unitary doses of dry powder includes: first and second supports, an indexing mechanism adapted to move the first and second supports, the indexing mechanism and the supports being configured so that in a first dispensing state of the device, the first and second supports are respectively in engagement with and disengaged from the indexing mechanism, in a second dispensing state of the device, the second and first supports are respectively in engagement with and disengaged from the indexing mechanism, and a changeover mechanism for causing the device to pass from the first dispensing state to the second dispensing state, to lock the second support while the device is in the first dispensing state, and to lock the first support while the device is in the second dispensing state.Type: GrantFiled: January 20, 2011Date of Patent: September 10, 2013Assignee: Pfizer LimitedInventors: Louise Annabel Bunch, Petra Jane Harris -
Patent number: 8528548Abstract: An inhaler (1) is proposed for inhaling a preparation (2) from a carrier (3) and/or through a delivery channel (16) as depicted in exemplary FIG. 1. The carrier or delivery channel is preferably flexible, flat, band-shaped, strip-shaped, thread-like, blister-like and/or film-like and can be set in vibration by a stream of air (5). The carrier or delivery channel is preferably set in vibration by a separate element (6), which for its part is set in motion or vibration by the stream of air. Alternatively, or in addition, the inhaler has a pump (10) with a telescopic pump chamber (20) for generating a stream of air for expelling and/or dispersing a preparation.Type: GrantFiled: August 17, 2007Date of Patent: September 10, 2013Assignee: Boehringer Ingelheim International GmbHInventor: Heinrich Kladders
-
Publication number: 20130228175Abstract: A dry inhaler system includes a vibrating mechanism. A supply of a dry powder is operatively coupled to the vibrating mechanism. A power source communicates with the vibrating mechanism. A sensor communicates with the vibrating mechanism. A feedback control communicates with the sensor and the power source. The feedback control controls power delivered to the vibrating mechanism relative to information provided by the sensor about the performance of the vibrating mechanism.Type: ApplicationFiled: April 9, 2013Publication date: September 5, 2013Applicant: MICRODOSE THERAPEUTX, INC.Inventors: Anand Gumaste, Henri Akouka
-
Patent number: 8522776Abstract: An inhalation device comprising a base having a slot for insertion of a single blister containing a dose of medicament to be inhaled into the base is disclosed. The inhaler has a mouthpiece pivotally mounted to the base which carries a blister piercing element operable to pierce a blister received in said slot when the mouthpiece is pivoted relative to the base. When a user inhales on the mouthpiece, the dose is entrained in an airflow and flows out of the blister through the mouthpiece and into the user's airway.Type: GrantFiled: June 12, 2009Date of Patent: September 3, 2013Assignee: Vectura Delivery Devices LimitedInventors: Matthew Paul Wright, Mike Sheldon, Matthew Sarkar, Ivan Milivojevic, Roger Clarke, Emma Lesley Williamson
-
Patent number: 8522778Abstract: A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device including: a nosepiece for fitting to a nostril of a subject; a substance supply unit for supplying a substance for delivery through the nosepiece; and a delivery prevention mechanism for preventing delivery of a substance through the nosepiece until the nosepiece is properly fitted to the nostril of the subject.Type: GrantFiled: April 9, 2010Date of Patent: September 3, 2013Assignee: OptiNose ASInventor: Per Gisle Djupesland
-
Patent number: 8522775Abstract: An inhaler (1) device for inhalation of a medicament from a pierceable capsule (10) comprises a housing (2) for receiving a medicament, capsule, closure means (3) for closing the housing, said closure means being moveable relative to the housing; piercing means (7) suitable for piercing a medicament capsule; wherein movement of the closure means relative to the housing causes movement of the piercing means, and wherein the device comprises an air inlet (71) and an air outlet (72) defining an inhalation passage therebetween, the passage comprising one or more vents (70).Type: GrantFiled: June 15, 2007Date of Patent: September 3, 2013Assignee: CIPLA LimitedInventors: Geena Malhotra, Amar Lulla
-
Patent number: 8522777Abstract: An inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets. The used part of the blister strip with empty blister pockets is wound onto a drum which is driven via a gear mechanism which is coupled to the drum via a spring. The spring allows for the different peripheral speeds of the wound-up part to be compensated.Type: GrantFiled: July 4, 2008Date of Patent: September 3, 2013Assignee: Boehringer Ingelheim International GmbHInventor: Timo Von Brunn
-
Publication number: 20130224259Abstract: The present disclosure provides DDAH modulators. Thus, the present disclosure provides a method of treating a patient suffering from a disorder characterized by excessive NO production and/or elevated DDAH activity, the method comprising administering to said patient an effective amount of a compound of one of formulae I-X. The present disclosure also provides a pharmaceutical composition comprising a compound of one of formulae I-X.Type: ApplicationFiled: February 13, 2013Publication date: August 29, 2013Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventor: The Board of Trustees of the Leland Stanford Junior University
-
Patent number: 8517009Abstract: A pulmonary drug delivery device having one or more vortexing elements which impart beneficial flow characteristics to an inspiratory air flow carrying a medicament into the patient's lungs.Type: GrantFiled: July 13, 2009Date of Patent: August 27, 2013Assignee: MAP Pharmaceuticals, Inc.Inventor: Prashant Kakade
-
Publication number: 20130213397Abstract: A dry powder inhaler may include a powder storage region, an inlet channel, a dispersion chamber, and an outlet channel. A geometry of the inhaler may be such that a flow profile is generated within the dispersion chamber that causes an actuator to oscillate, enabling the actuator when oscillating to deaggregate powdered medicament within the dispersion chamber to be aerosolized and entrained by the air and delivered to a patient through the outlet channel.Type: ApplicationFiled: February 21, 2013Publication date: August 22, 2013Applicant: RESPIRA THERAPEUTICS, INC.Inventor: RESPIRA THERAPEUTICS, INC.
-
Publication number: 20130213392Abstract: The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein individual blister packs are positioned within the housing to be simultaneously engaged with the flow channel and the vibration element. The flow channel includes a blister pack clamping surface that engages the blister pack near the top of the crown and allows the blister three rotational degrees of freedom. The advantages of this arrangement include improved consistency and higher airspeed of the synthetic jet, as well as other advantages.Type: ApplicationFiled: March 15, 2013Publication date: August 22, 2013Applicant: MICRODOSE THERAPEUTX, INC.Inventor: MICRODOSE THERAPEUTX, INC.
-
Publication number: 20130213395Abstract: A medicinal inhalation device having a non-metal coating applied by plasma deposition under ion bombardment conditions.Type: ApplicationFiled: April 2, 2013Publication date: August 22, 2013Applicant: 3M Innovative Properties CompanyInventor: 3M Innovative Properties Company
-
Publication number: 20130213398Abstract: The present invention is directed toward respirable dry particles for delivery of divalent metal cation salts and/or monovalent cation salts to the respiratory tract and methods for treating a subject having a respiratory disease and/or infection.Type: ApplicationFiled: August 26, 2011Publication date: August 22, 2013Inventors: Michael M. Lipp, Jean C. Sung, Robert W. Clarke, David L. Hava
-
Patent number: 8511304Abstract: There is provided a medicament dispenser for use with plural elongate form medicament carriers, each having multiple distinct medicament dose portions carried thereby, the dispenser having a dispensing mechanism for dispensing the distinct medicament dose portions carried by each of the plural medicament carriers. The mechanism comprises a receiving station for receiving each of the plural medicament carriers; a release for releasing a distinct medicament dose portion from each of the plural medicament carriers on receipt thereof by the receiving station; an outlet, positioned to be in communication with the distinct medicament dose portions releasable by said a release; and an indexer for individually indexing the distinct medicament dose portions of each of the plural medicament carriers.Type: GrantFiled: January 22, 2003Date of Patent: August 20, 2013Assignee: Glaxo Group LimitedInventors: Gregor John McLennan Anderson, Stanley George Bonney, Michael Birsha Davies, Daniel Thomas De Sansmarez Lintell, Alan Anthony Wilson
-
Patent number: 8511302Abstract: A dose counter mechanism is suitable for use with a medicament delivery device. The dose counter mechanism comprises a rollable tape (20) provided with indicia (22), a tape housing (10) and a tape collector spool (40). The tape housing comprises a tape dispenser housing (14) within which, in use, a roll (24) of the tape is inserted and a tape collector spool housing (16) within which, in use, the tape collector spool is mounted. The tape dispenser housing and the tape collector spool housing are connected by a tape display area (15).Type: GrantFiled: April 22, 2005Date of Patent: August 20, 2013Assignee: Innovata Biomed LimitedInventor: Philip Carl Parkes
-
Publication number: 20130206142Abstract: An inhaler, the inhaler including a body (104) and a cartridge (106), the cartridge comprising a dose storage portion (122) and an airway (124), 102 the dose storage portion being suitable for containing a plurality of doses of an inhalable medicament, the airway including a mouthpiece (128) at an end thereof, the inhaler device configured and arranged such that a dose of inhalable medicament from the dose storage portion can be accessed and arranged in a delivery configuration for delivery to a user through the airway upon inhalation through the mouthpiece by the user, the inhaler characterised in that the cartridge is replaceably removable from the body.Type: ApplicationFiled: September 28, 2011Publication date: August 15, 2013Applicant: NOVARTIS AGInventors: Steven Dudley, John Palmer-Felgate, Sean Reynolds, Iain Breakwell, Jon Jamin, Steve Augustyn, Grant Smetham, Laura Kaye, John McGarva