Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

Abstract: It becomes possible to stably deliver an inhaled particulate medicine to a targeted part for administration while reducing burdens on a patient. When supplying the particulate medicine into a body by an airflow, a multi-layer flow composed of a core airflow (A) and a clad airflow (B) outside the core airflow is used as the airflow. The medicine is dispersed in the core airflow (A) and velocity of the clad airflow (B) is set higher than that of the core airflow (A). The medicine dispersed in the core airflow (A) reaches the targeted part for administration while the medicine is protected by the clad airflow (B) without contacting a larynx and the like. A cross-sectional area of the airflow is set smaller than that of the larynx. The airflow is supplied to an upper side of the larynx.

Abstract: A supplemental oxygen delivery system is described in which Aerosol is delivered into a housing 10, 20, which sits in the circuit from the supplemental oxygen supply and optional humidifier. The supplemental oxygen passes through this chamber 10, 20 in which the aerosol is located, and collects the aerosol transporting it to a patient via a nasal cannula 3 or a face mask 4. An aerosol generator 9 is mounted to the housing 10, 20 and delivers aerosol into an oxygen stream 13 flowing between an inlet 14 and an outlet 15 of the housing 10. The housing 10 also has a removable plug 16 in the base 17 thereof for draining any liquid that accumulates in the housing 10. There is no disruption of oxygen delivery to patients using nasal cannulas who currently have to use a separate face-mask when receiving nebulized medication.

Abstract: A device, system and method is provided for dispersing an aerosol formulation comprising a medicament. The device may be useful in administering inhaleable vaccines and the like. The device designed for low cost and applicability to a multitude of patient populations. The device has a spacer (10) is suitable for use with a wide range of aerosolized formulations, particularly powders. The spacer (10) may be an expandable volume spacer (10). The spacer (10) may also be used with other inhalation aids (80). The spacer (10) may include a multi-purpose outlet (40) for use with different groups within the target patient population.

Abstract: An open-circuit liquid ventilation system includes a reservoir containing a breathable liquid, a patient interface receiving breathable liquid from the reservoir, a pump directing breathable liquid from the reservoir to the patient, a controller for the pump, and a tank for storing used breathable liquid. The system may be passive regarding expired liquid. Alternatively, the system may be active and include a bypass line connected to the pump such that used breathable liquid is drawn from the patient. The patient interface may be adapted to interface a gas ventilation system to facilitate a rapid conversion from gas to liquid ventilation. The system may include sensors monitoring pressure and volume parameters and may include an output displaying information including schematics and real time tracings regarding a ventilation procedure.

Abstract: The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at a low inspiratory flow rate for an initial period of time to increase bioavailability of the active agent.

Abstract: The invention relates to a dispenser (1) for powdery compositions (M) contained in a separate pack, in particular compositions (M) contained in a blister pack (18), wherein the pack has a container part (14) with tear-off container cover (16), wherein furthermore an aspirated stream of air is sucked for the most part through the container part (14), after the container cover (16) has been removed from the container part (14), in such a way that two air streams (a, b) entering through slits (29) of a lid (19) empty the container part (15) from the direction of its two ends and, after coming together, pass into a swirl chamber (7) arranged upstream of a mouthpiece (3). In order to further optimize a dispenser in terms of flow technology, it is proposed that the air stream channel (27) designed as an arc-shaped path leads to the more distant end of the container part (14) and encompasses the container part (14) with an at least 180° curve area (52).

Abstract: Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals, or to reduce the symptoms of allergy or other pulmonary disease. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be isotonic saline and, optionally, a carrier. The formulation may be administered as a liquid solution, suspension, aerosol, or powder where the particles consist basically of an osmotically active solute. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.

Abstract: The present invention provides a method and apparatus for controlling a patient's body temperature and in particular for inducing therapeutic hypothermia. Various embodiments of the system are described. The system includes: a source of breathing gas, which may be in the form of a compressed breathing gas mixture; a heat exchanger or other heating and/or cooling device; and a breathing interface, such as a breathing mask or tracheal tube. Optionally, the system may include additional features, such as a mechanical respirator, a nebulizer for introducing medication into the breathing gas, a body temperature probe and a feedback controller. The system can use air or a specialized breathing gas mixture, such as He/O.sub.2 or SF/O.sub.2 to increase the heat transfer rate. In addition, the system may include an ice particle generator for introducing fine ice particles into the flow of breathing gas to further increase the heat transfer rate.

Abstract: A pressure support system (10) comprises a humidifier (20) adapted to increase the amount of water vapor entrained in a supply of breathing gas, and a positive air pressure device (30) fluidly coupled downstream of the humidifier. The positive air pressure device is structured to generate a positive pressure flow of breathing gas from the supply of breathing gas received from the outlet of the humidifier.

Abstract: An inhaler which comprises a base having at least one sealed cavity containing medicament and a foil portion comprising two sides, one side being attached to the base for sealing the medicament within the cavity. A separating element is attached to the other side of the foil portion for separating the foil portion from the cavity, the separating element having a first end and an opposite second end, wherein the separating element is movable to an intermediate tilted position in which said first end is moved-away from the cavity. The separating element is further movable from the intermediate tilted position to a removed position in which also said second end is moved-away from the cavity so that the foil portion is removed from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow.

Abstract: The present invention relates to an inhaler with a novel mouthpiece having a microbiological protective function. The inhalers are used for administration of a pharmaceutical substance, substance formulation or substance mixture.

Abstract: A nebulizer for efficiently and reliably delivering aerosolized fluid to an inhaling patient is disclosed. The nebulizer includes a fluid channel air inlet and fluid channel air inlet valve responsive to either a manual force external of the nebulizer, or a patient's breathing, to begin the nebulization process. Also provided is a method of providing nebulization including the steps of moving a fluid channel air inlet valve against a fluid channel air inlet so that a negative pressure may build up over the fluid in the fluid channel to draw fluid from the fluid reservoir and begin nebulization during inhalation.

Abstract: A dose delivery device with a mouthpiece having an inlet, an outlet, and an air path extending between the inlet and the outlet. A dose chamber having an opening may hold a dose, e.g., for inhalation by a user. A disc element may be arranged to move between a closed position in which the disc element closes the opening of the dose chamber, and an open position in which the disc opens the dose chamber to permit introduction of the dose into the air path of the device. Movement of the disc element from the closed position to the open position may be in a direction away from the dose chamber (e.g., a puller may engage the disc element and pull the element away from the chamber) and may leave a substantial portion of the dose in the dose chamber.

Abstract: The disclosure relates to methods for delivery of serum amyloid P to the respiratory system. Pharmaceutical compositions comprising SAP suitable for respiratory delivery are also provided.

Abstract: An inhaler which comprises a base having a plurality of consecutive sealed cavities containing medicament. Foil portions are on one side attached to the base for sealing the medicament within respective associated cavities. A plurality of separating elements are attached to the other side of the foil portions, each separating element being associated with a respective cavity for separating a foil portion from that cavity. Each separating element can be moved-away from its associated cavity so that the sealing foil portion is separated from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow, and then returned with the attached foil portion to cover its associated cavity. A method of operating an inhaler is also disclosed.

Abstract: The present disclosure provides dry powder inhalers, containers for carrying a dose of dry powder medicament particles for dry powder inhalers, and a hinge that, while enjoying broader applicability, may be used in such inhalers.

Abstract: In order to improve the administration of powdered pharmaceuticals, the invention proposes a storage system for powdered pharmaceuticals, in particular for use or integration in a powder inhaler, for receiving a multiplicity of doses of at least one medically active substance, with at least two storage spaces (4) which are separate from each other and are each intended to hold a multiplicity of doses of a medically active substance, and the invention also proposes an inhaler for powdered pharmaceuticals, the inhaler comprising such a pharmaceutical powder cartridge system (1) as an integral part or as an exchangeable part.

Abstract: An inhaler for delivery of a powder-form inhalation formulation from a blister strip has a plurality of blister pockets and uses a pivotable mouthpiece cover to move the blister strip onward. The mouthpiece cover is drivingly coupled with a conveyor wheel to drive the conveying wheel and to move the blister strip onward, and the axis of the actuator and of the conveying wheel is identical to the cover axis of the mouthpiece cover.

Abstract: A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.

Abstract: The present invention provides a dry-powder inhaler device comprising: a casing; an air inlet located at a first terminus of the casing; a powder delivery port located at a second terminus of the casing, which is positioned distal to the air inlet; and an elongated assembly located within an interior of the casing. A first terminus is located proximally to the air inlet, a second terminus is located proximally to the powder delivery port, and the assembly is fitted within the casing such that said assembly partially rotates therein about a single axis. The assembly has at least one compartment containing dry-powder, which is located proximally to the second terminus. The compartment with a dry-powder comprises a porous structure encasing the dry-powder; whereby airflow through the device causes the assembly to partially rotate within the casing about a single axis and release the dry-powder in the airflow.

Abstract: The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering a biological agent in a breathable liquid to a lung of a patient. The steps of both the transient delivery method and the steady state delivery method can be controlled by a servo-control unit. A supplementary biological agent delivery step can be performed in both the transient method of delivering a biological agent and the steady state method of delivering a biological agent.

Abstract: Dry powder inhalers include: (a) a first generally planar spiral travel path in an inhaler body, wherein the first spiral travel path has a plurality of adjacent curvilinear channels forming lanes with upstanding sidewalls, including an inner lane and an outer lane; and (b) a plurality of discrete sealed microcartridges with substantially rigid bodies disposed in the first travel path, each comprising a pre-metered (typically dose) amount of dry powder, the microcartridges being configured to slidably advance along the first travel path toward an inhalation chamber that merges into an inhalation output port. In operation, at least one microcartridge is held in the inhalation chamber to release the dry powder therein during inhalation.

Abstract: In order to improve the administration of powdered pharmaceuticals, the invention proposes a storage system for powdered pharmaceuticals, in particular for use or integration in a powder inhaler, for receiving a multiplicity of doses of at least one medically active substance, with at least two storage spaces (4) which are separate from each other and are each intended to hold a multiplicity of doses of a medically active substance, and the invention also proposes an inhaler for powdered pharmaceuticals, the inhaler comprising such a pharmaceutical powder cartridge system (1) as an integral part or as an exchangeable part.

Abstract: An actuator (2) for an inhaler (1) comprising a longitudinally extending body (3), a delivery passage at (or near to) a first end of the body (3) and a retained cover (7) for the delivery passage, the actuator (2) having at least one profile (9) arranged to guide the cover (7) from a closed position occluding at least a user-opening (6) of the delivery passage to a remote location in which the user-opening (6) of the delivery passage is unoccluded wherein the cover (7) and the at least one profile (9) are configured and arranged such that, in use of the actuator (2), in the guided movement of the cover (7) from the closed position to the remote location, the cover (7) is glided by the user towards the second end of the body (3).

Abstract: A dry-powder inhaler device comprising an air inlet (40), an air outlet (4), an assembly comprising a mesh-based package (10) containing a dry-powder drug (16), the assembly being positioned to undergo agitation, the device having an airflow therethrough from the air inlet to the outlet, which airflow at least indirectly causes the agitation and wherein the agitation of the assembly in conjunction with the airflow causes the particles of the dry-powder drug to exit from the mesh-based package and become entrained in the airflow.

Abstract: A system, method, and apparatus for modified air delivery. A formable mask having an oxygen supply port and exhaled air removal components for the delivery of modified air to a user. An oxygen delivery system uses the formable mask and oxygen supply components. Oxygen supply components include a flow rate throttling valve and an O2 reservoir to conserve O2 use and insure O2 availability to a patient. The system modifies the air for delivery using an air modification module to condition the air for delivery of aerosolized particles to the user.

Abstract: The disclosure describes methods and inhalers that deagglomerate dry powder using inspiratory effort of a user of an inhaler. Inhaler fin and mesh configurations are described that facilitate deagglomeration. At least in steady state conditions, a dry powder and airflow pattern can be generated having turbulence with flow vortices, some of which may have a vortex having an axis of rotation that extends in an inspiratory flow direction while others may have a vortex that is substantially orthogonal to the inspiratory flow direction in an inspiratory airflow path, as an amount of dry powder travels through the inhaler to thereby deagglomerate the dry powder without trapping undue amounts of the dry powder during inhalation.

Abstract: It has a complex shaped hollow body with front mouthpiece (2) covered by dust cap. Drug strip (1) is held in channel (7) with a drug hole (6). Handle (4) with a sharp piercing rod (5) moves on a pivot (10) at the body back. The pierced powder falls through drug hole (6) into drug chamber (23) with a bottom sliding drug release plate (11) having a knob (8), a spring (14) enclosed in sleeves (15,17) and having a drug hole (12). The hollow body has the back air hole (3) with a dust filter (22), then narrows to a jet hole (19) & continues as hollow mouthpiece. A baffle mesh (16) breaks falling powder into a spray. To use, drug strip (1) is pierced by handle (4), inhaler kept in mouth, and knob (8) pressed and inhaled. Plate (11) slides drug hole (12), drug falls on baffle (16), air jet breaks and forms drug spray for more lung deposit. For drugs in capsule, the inhaler is modified with middle placed capsule (26) with a back piercing rod (25).

Abstract: A body section 2 is formed with a capsule insertion hole 6. A movable section 3 includes a capsule puncture needle 9 arranged to be moved into or out of the capsule insertion hole 6. The body section 2 and the movable section 3 are connected to be relatively pivoted at least between a posture in which the capsule insertion hole 6 is exposed, and a posture in which the capsule insertion hole 6 is hid by the body section 2. The body section 2 (a side wall 6e of a protrusion 6a) is arranged to restrict the advancing movement of the capsule puncture needle 9 in the state in which the body section 2 and the movable section 3 are in the posture in which the capsule insertion hole 6 is exposed.

Abstract: An inhaler comprising: at least one cover element (11, 12) that is movable between a closed position and an open position; individual reservoirs formed on a reservoir substrate; movable support means (50) that are displaceable between a non-dispensing position and a dispensing position; reservoir opening means (80) for opening a respective reservoir in the dispensing position; loading means (800) for urging said movable support means towards said dispensing position; blocking means (100) for retaining said movable support means in the non-dispensing position; and trigger means (60) for releasing said blocking means; said loading means including an elastically-deformable loading element (51) that co-operates with a cam surface (910) that is connected to said at least one movable cover element; and said cam surface comprising a first portion that is adapted to load said loading means, and a second portion that co-operates with said loaded loading means.

Abstract: A medication inhaler for concurrently delivering multiple doses of medications including an inhaler body having a medication container chamber for receiving a plurality of medication containers and at least one air passage connecting the medication container chamber with external air, a mouthpiece axially engageable with the inhaler body and having a mouthpiece chamber for communication with a patient's respiratory system, and a hollow medication delivery needle communicating with the mouthpiece chamber. A medication delivery needle penetrates the medication containers when the inhaler is actuated and has at least one opening for passing exterior air and medication from interior spaces of the medication containers and through the needle to mouthpiece.

Abstract: A dry powder suitable for inhalation n a dry powder inhaler, the powder comprising a carrier, an active agent and at least 0.5% by weight of magnesium stearate, the powder being further characterized in that the less than 10% of the surface of the carrier material is covered with particles of magnesium stearate. The invention is also directed to a method of making dry powders by blending together the ingredients mentioned in a diffusion blender for a period of time that is less than 60 minutes.

Abstract: A dose delivery device with a mouthpiece having an inlet, an outlet, and an air path extending between the inlet and the outlet. A dose chamber having an opening may hold a dose, e.g., for inhalation by a user. One or more bypass inlets, two or more dispersion chambers, and/or flow arrangements in which incoming and outgoing flow in a dispersion chamber are transverse may be used to disperse a dose for delivery to a user.

Abstract: The method and system ventilates a patient's airway during the inspiratory phase and expiratory phase from a source of pressurized gas, typically from a compressor. The system and method supplies, to the patient airway during the inspiratory phase, a plurality of pulses of small volumes of gas from the gas source, and adds, in succession, pulses of small volumes of gas to provide successively greater volumes of gas successively increasing in pulsatile form the pressure of the gas in the patient's airway. This addition of successively greater volumes of gas serves to provide diffusive ventilation to the patient during the inspiratory phase, and, permits the patient to exhale during the expiratory phase.

Abstract: The invention relates to a spray drying system and a method for its operation that provides a composition of dry. or essentially solvent free, particles from a solution of an agent. The system comprises a generally vertical tube reactor arranged for counter-current removal of solvent from a process flow fed with aerosol droplets of solution descending from the top said reactor with an ascending gas flow. The reactor includes a perforated process tube for transportation of the process flow from the outlet of an aerosol generating device to a dry particle collecting device. A membrane sleeve essentially surrounds the peripheral area of said process tube and separates the descending process stream from the ascending gas stream. Vaporized solvent is transported from the process stream to the ascending gas stream. A reactor housing is sealingly covering said process tube and membrane sleeve and is provided with means for introducing and/or removing the process fluids.

Abstract: Aerosol therapy device comprising a nebuliser (10) for generating an aerosol and forming an aerosol flow, a first nosepiece (11) for introducing the aerosol flow into one of the two nostrils (12) of a user, a pressure fluctuation source for generating a pressure fluctuation (DS), a second nosepiece (14) for introducing the pressure fluctuation into the other of the two nostrils (15) of the user in order to superimpose the pressure fluctuation and the aerosol flow, and a sensor system comprising a first pressure sensor (19) for detecting the signal of the pressure fluctuation that arrives at the first nosepiece (11), and an evaluation means (18) that concludes the degree of closure of the velum of the user based on the signal.

Abstract: This invention relates to dry powder inhalers and drug products and, more particularly to polyflux colliders useful for de-agglomerating dry powder in dry powder dispensers. Various embodiments provide drug products, dry powder inhalers and polyflux collider arrangement. With various embodiments of the present invention, a polyflux collider is provided which utilizes colliding streams of dry powder to provide desirable de-agglomerating capability for dry powder dispensers.

Abstract: The present invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, the present invention provides general and specific compositions and methods that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses.

Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

Abstract: An inhaler for powdery, in particular medicinal, substances includes a suction air channel, which leads to a mouthpiece. The inhaler also has a storage chamber for storing the substance and a linearly moving dosing chamber for apportioning and distributing a specified amount of substance from the storage chamber to a transfer point to the suction air flow. The novel inhaler represents a structurally simple solution that makes it possible to eliminate adding an external air flow. To this end, a component of the suction air flow, which is located in the direction of extension of the dosing chamber, empties said dosing chamber.

Abstract: A sealed self-piercing capsule for storing and delivering a substance, such as a medicine, comprises one or more barrier layers forming a sealed chamber for containing the substance. An internal puncturing mechanism is disposed within the capsule chamber for puncturing a barrier layer to release the substance from the chamber. The internal puncturing mechanism may comprise a sharpened edge located on a movable tube, which moves relative to a barrier layer forming the sealed chamber to puncture the barrier layer.

Abstract: A one dose at a time, non-pressurized fluid dispensing canister from which the or each dose is dispensed as a result of two surfaces (21, 22) of the canister moving towards one another under the control of the user, wherein the canister incorporates a mechanism which, once a first dose has been dispensed, automatically prevents any further dispensing movement of the surfaces (21, 22) (in the case where the canister is a one-dosage only canister) or (where the canister is a multiple-dosage-dispensing canister) allows such movement only after the two surfaces (21, 22) have first been moved in a direction or directions other than that which alone caused the first dose to be dispensed.

Abstract: A breath-controlled inhalation therapy device includes an obturation mechanism, obturating a nozzle opening through which a pressurised gas, preferably pressurised air, is issued when the device is in operation. An actuation mechanism actuates the obturation mechanism only in the exhalation phases of the respiration cycle of a patient. The fluid to be atomised is therefore substantially atomised only in the inhalation phases.

Abstract: An inhaler for powdery, in particular medical, substances is formed with a suction air channel, which leads to a mouthpiece. The inhaler also has a storage chamber for storing the substance and a linearly moving dosing chamber for apportioning a specified amount of substance from the storage chamber to a transfer point to the suction air flow. The aim of the invention is to obtain a structurally simple solution that makes it possible to eliminate adding an external air flow. To this end, a component of the suction air flow, which is located in the direction of extension of the dosing chamber, empties said dosing chamber.

Abstract: A fault indicator for a strip advancement mechanism comprising a base that defines a fault sensing portion of a path for at least a component of a strip, an element for bearing against a strip, or a component of the strip, while it passes through the fault sensing portion of the path, wherein the element is adapted to move from that bearing or non-fault position, to a fault indicating position in the event of the strip or the component of the strip ceasing to pass through the fault sensing portion of the path.

Abstract: A device comprising an inhaler suitable for administration of a stable dry powder blend is described, which contains a blend comprising a thyroid hormone, in particular levothyroxine sodium, and other additives such as lactose particles, sodium starch glycolate, magnesium stearate, and talc silicified.

Abstract: A method and arrangement for detecting a leak in an anesthesia system. The method includes controlling respiratory movements by means of ventilator gas flows and measuring the ventilator gas flow added for an inspiration and removed for an expiration. The method also includes supplying a fresh gas flow for a respiration and measuring the fresh gas flow added for the respiration. The method further includes receiving information indicative of the measured gas flows, determining based on said received information both the gas volume added and the gas volume removed and comparing these determined gas volumes to each other. The method also includes determining based on comparing the anesthesia system leakage.

Abstract: A medicine ejection apparatus which ejects a medicine for medicating a user has a medicine ejecting unit, which has an element that generates energy for ejecting the medicine, a drive control unit which controls a drive start and a drive stop of the element, and an ejection amount determining unit, which determines a total amount of a medicine that is ejected from the medicine ejecting unit after the element performs a drive stop. The drive control unit enables the element to perform driving to eject an amount of medicine calculated from a difference between a set ejection amount and the total amount of medicine that has actually been ejected, when the total amount ejected, as determined by the ejection amount determining unit, is less than the set ejection amount.

Abstract: A liquid medicine reservoir that supplies liquid medicine to a liquid-medicine discharging portion via a communicating portion includes a cylindrical body configured to hold the liquid medicine therein, a first sealing portion to which the communicating portion is connected, the first sealing portion sealing the cylindrical body, and a second sealing portion configured to seal an end of the cylindrical body opposite the first sealing portion. At least one of the first sealing portion and the second sealing portion move relative to each other in accordance with the amount of liquid medicine. A substance configured to inhibit discharging of the liquid medicine is stored in a space in the cylindrical body that is on an inner side of the second sealing portion and that is separate from the liquid medicine.