Abstract: The present invention provides a method and apparatus for controlling a patient's body temperature and in particular for inducing therapeutic hypothermia. Various embodiments of the system are described. The system includes: a source of breathing gas, which may be in the form of a compressed breathing gas mixture; a heat exchanger or other heating and/or cooling device; and a breathing interface, such as a breathing mask or tracheal tube. Optionally, the system may include additional features, such as a mechanical respirator, a nebulizer for introducing medication into the breathing gas, a body temperature probe and a feedback controller. The system can use air or a specialized breathing gas mixture, such as He/O2 or SF/O2 to increase the heat transfer rate. In addition, the system may include an ice particle generator for introducing fine ice particles into the flow of breathing gas to further increase the heat transfer rate.

Abstract: Devices for delivery of dry powder formulations are also provided. Devices can be single-use devices. Formulations and methods of manufacture are provided for dry powder compositions suitable for intranasal administration. Also provided are methods of use for preventing or controlling emesis and other diseases and disorders and devices, compositions, and methods for nasal delivery of therapeutic formulations.

Abstract: The bi-functional inhaling device has an elliptic shape in the frontal, lateral and transversal plane and includes a lower part and an upper part, a lower cap being located at the lower part to accommodate inside a cartridge made up of a lower cap, a strip of absorbent material, a body and an upper cap of the cartridge. An adapter for oral inhaling is mounted over the upper cap of the cartridge, the adapter being covered with a protection cap. An adapter for nasal inhaling is mounted over the upper cap of the cartridge. A membrane is secured on the base surface of the upper cap of the cartridge, the membrane having the role of a one-way valve. Natural salt crystals are introduced inside the cartridge, in the space created between the lower cap, the upper cap and the body of the cartridge.

Abstract: The present invention relates to capsules for housing pharmaceutical preparations for powder inhalers with increased medicinal product safety and capsules for pharmaceutical preparations for powder inhalers with improved adaption to use in powder inhalers. The capsules consist of non-water-soluble, hydrophobic plastics, which themselves do not substantially influence the pharmaceutical quality of the contents, but improve the usability of the filled capsules in respect of their operation, the period of use and/or the geographical location of their use and are advantageous in various steps from manufacture to use.

Abstract: A transition adapter component of a ventilator aerosol delivery system for delivering an aerosol to a patient, includes a housing having a proximal end and a distal end, the proximal end having an aerosol passage for receiving an aerosol produced by a heated capillary and a gas connection port for receiving carrier gas from a ventilator, which is in communication with a plurality of gas entry ports within the transition adapter. An inner cavity of the transition adapter receives the aerosol from the heated capillary and the streams of carrier gas from the plurality of gas exit ports within the transition adapter and directs the streams of carrier gas at least partially encircling and in parallel with the aerosol. An exit port on the distal end of the transition adapter housing delivers an entrained aerosol to an aerosol delivery connector.

Abstract: Dose counter assemblies are provided herein which allow for the counting of used doses of a medical inhaler. In one aspect, one dose counter ring is utilized. This provides for dose counting but with inherent limitations in the number of doses which may be counted. In a second, and preferred, aspect of the subject invention, two cooperating does counter rings are utilized which allow for adjacent digits to be displayed, thereby allowing an increased number of doses to be counted. Advantageously, with the subject invention, due to mechanical interactions, reliable dose counting can be achieved with the subject invention.

Abstract: There is provided an actuation counter comprising a driver feature having one or more driver elements, which driver feature is arranged for drivable movement in response to an actuation; and a count member including one or more drive receipt elements arranged thereon for receipt of drive from said one or more driver elements of the driver feature for drivable movement of the count member. The driver feature includes one or more brake elements arranged to selectively interact with the count member to prevent overrun thereof when registering a count of an actuation. The actuation is suitably arranged for use with a drug dispenser device.

Abstract: Compounds having formulas (I) to (VIII), salts thereof, or combinations thereof and pharmaceutical compositions comprising one or more these compounds are described herein for the treatment of HIV and neurodegenerative effects caused by HIV. Also provided herein are methods and a kit for inhibiting HIV-1, treating latent HIV in the brain, and preventing HIV-mediated cognitive decline and HIV dementia comprising administering the compounds having the formulas (I) to (VIII) and pharmaceutical compositions comprising the compounds having these formulas. The compounds having formulas I through VIII are curcumin analogs which are advantageously characterized as having anti-retroviral, neuroprotective, anti-glucosidase, and anti-HIV integrase properties. In one aspect, the pharmaceutical composition is delivered intranasally.

Abstract: A basic air flow device includes a flow passage having opposite ends. The flow passage is divided into a plurality of sequential portions between the ends including an inlet portion extending into the flow passage from an inlet end, an outlet portion disposed at the opposite end of the flow passage from the inlet portion, and at least one intermediate passage portion between the inlet passage portion and the outlet passage portion. Each of a plurality of divider sets are positioned in a different sequential portion of the passage to divide that passage portion into a predetermined number of sub passages, whereby the flow passage is sequentially divided into an increasing number of sub flow passages progressing from the inlet portion to the outlet portion. A larger device can be assembled using a parallel plurality of the basic devices.

Abstract: A dry powder inhaler includes a chamber holding a bead-like actuator to which a powdered medicament is adhered. Air is drawn into the chamber through an inlet flow channel and exits through an outlet flow channel. The bead-like actuator oscillates in response to the air flow, dislodging powdered medicament to be entrained in the air flow and delivered to the patient.

Abstract: The invention relates to dry powder inhalation apparatus usually operable by breath of a user which provides for controlled and smooth transfer of medicament during multiple actuations by a user. A mechanism of the apparatus for achieving this controlled and smooth transfer includes a device (4) normally held adjacent a reservoir for receiving medicament in a cup or receptacle (15) and which is generally movable transversely of a longitudinal axis of the apparatus to delivery channels of the apparatus. This bodily shifting of the device (4) is achieved by a yoke acting on an abutment (16) thereof. Spillage of medicament in the apparatus is avoided.

Abstract: The present disclosure provides a method and device for delivering a pharmaceutical to the airway of a human or animal patient. In one aspect, the device includes a dose drum formed into a cylinder and including a plurality of dose compartments for containing individual doses. In another aspect, the device may include a reservoir containing a pharmaceutical material in bulk form and a metering recess for metering the pharmaceutical material to form a pharmaceutical dose. Another aspect provides an inhaler with a combined reservoir and dosing chamber configured to contain multiple doses of a pharmaceutical material.

Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.

Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a p

Abstract: Methods and apparatuses for the pulmonary delivery of a composition, such as methods and apparatuses for dispersing dry powder medicaments for inhalation by a patient. Elements or aspects of the apparatuses, including receptacle puncturing, mechanisms, deoccluding devices, receptacle impacting devices, and receptacle lock devices or systems.

Abstract: A fluid dispenser device including a body provided with a dispenser orifice; at least one reservoir containing a dose of fluid, such as pharmaceutical powder; a movable support mechanism that receives at least one reservoir, and that is displaceable between a non-dispensing position and a dispensing position. A reservoir-opening mechanism opens a reservoir when actuated and a stressing mechanism that includes an elastically-deformable stressing element, urges the movable support mechanism towards a dispensing position. An inhalation trigger releases a blocking element and which enables the movable support mechanism, together with a reservoir, to be displaced towards the dispensing position at the time a user inhales.

Abstract: A fluid dispenser device comprising: a body (10); at least one individual reservoir (21); movable support means (50) that receive at least one reservoir (21), and that are displaceable between a non-dispensing position and a dispensing position; reservoir-opening means (80) for opening a reservoir when said opening means are actuated; loading means (800) for urging said movable support means towards said dispensing position; blocking means (100) for retaining said movable support means in the non-dispensing position; and inhalation trigger means (60); said blocking means (100) comprising a blocking element (110) that is movable between a blocking position and an unblocking position, said blocking element (110) co-operating with a projection (501) that is secured to movable support means (50).

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

Abstract: There is provided a drug dispenser device comprising a housing; extending from the housing, an outlet for insertion into a body cavity of a patient; provided to the housing and moveable with respect thereto, a drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet; connecting to the drug discharge device, a container collar; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element, the transfer element including an actuating portion; provided to the housing, at least one finger operable member moveable to apply a force to the actuating portion of the transfer element to move the transfer element along the longitudinal axis in a first direction; linking the container collar with the transfer element, a biasing mechanism to store biasing ene

Abstract: A dry powder inhaler is provided herein having a powder housing defined on an exterior by a generally cylindrical wall. Within the interior volume of the wall, a central passageway is provided through which certain components of the dry powder inhaler may pass. In addition, a powder reservoir is defined within the interior volume having a generally crescent-shaped profile formed along a substantial length of the wall. The powder reservoir terminates at end points between which is defined an isolated inhalation channel. With the configuration provided herein, the powder reservoir has a substantial working length exposed at its bottom to permit removal of medication therefrom. Advantageously, with this configuration, a relatively large amount of medication may be maintained, and obtained access to, in the powder reservoir.

Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity.

Abstract: A sealed self-piercing capsule for storing and delivering a substance, such as a medicine, comprises one or more barrier layers forming a sealed chamber for containing the substance. An internal puncturing mechanism is disposed within the capsule chamber for puncturing a barrier layer to release the substance from the chamber. The internal puncturing mechanism may comprise a sharpened edge located on a movable tube, which moves relative to a barrier layer forming the sealed chamber to puncture the barrier layer.

Abstract: The invention refers to an inhalation device provided with a dose ring intended for storage and release of substances in powder form such as a drug, comprising a plurality of substantially circular recesses or powder chambers for storing a respective dose of a preloaded powdery substance, and an air channel or uncovering device for dispensing one dose at a time, wherein an advancing mechanism is arranged to feed the dose ring in its direction of rotation one powder chamber at a time.

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

Abstract: A pharmaceutical composition, method, and article manufacture for the treatment of asthma by inhalation from a pressurized metered dose inhaler (pM DI), a dry powder inhaler (DPI) or nebulizer, the composition and method being based on a combination of a short acting beta agonist (SABA) and an inhaled mometasone in a form adapted to be delivered for inhalation from the MDI, DPI or nebulizer.

Abstract: An improved inhalation device is provided for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device includes a staple assembly comprising a plunger and staple that are securely and robustly coupled to one another. Embodiments of the inhalation device have a cap that prevents or reduces the amount of dust and grime entering into the device. The cap is additionally configured to prevent or reduce inadvertent and unintentional operation of the device. The body portion and first casing portion of certain embodiments of the inhalation device are sealably coupled, restricting or reducing undesirable flow pathways that have an adverse effect on the operation of the device.

Abstract: To provide an inhalation device which has improved use properties, particularly advanced moisture protection while in use, an inhalation device (1) for powder drugs is proposed comprising at least one storage chamber (13) for accommodating a plurality of drug powder doses and a dosing device which includes at least one dosing slider (15) which is movable approximately with a translatory movement in a dosing slider passage (16) at least from a filling position into an emptying position, wherein the inhalation device (1) further includes a device for inhalation-triggered automatic movement of the dosing slider (15) from its filling position into the emptying position and a return device for automatic movement of the dosing slider (15) back into the filling position.

Abstract: A dry powder inhaler (2) comprises a housing (6, 8) including a mouthpiece (10) and a cover (11, 12) movably mounted to the housing (6, 8). The cover (11, 12) is movable between an open configuration of the inhaler (2) in which the mouthpiece (10) is exposed for use and a closed configuration of the inhaler (2) in which the mouthpiece (10) is enclosed. In the open position, the cover (11, 12) at least partly defines an inlet aperture (71) to an inhalation air flow path leading through the inhaler (2) and communicating with the mouthpiece (10). The inlet aperture (71) is positioned in such a way that makes it difficult for a user to obstruct it when using the inhaler (2). Preferably, in the closed position, the mouthpiece (10) is received into the inlet aperture (71) to protect the mouthpiece (10) when the inhaler (2) is stored.

Abstract: A nebulizer to deliver a medicament that includes a housing having a reservoir for the medicament, an aerosol generator that can be supplied the medicament from the reservoir, where the generator aerosolizes at least a portion of the medicament into an aerosol, a gas venting inlet to permit a gas to enter the nebulizer and form a mixture with the aerosol, and a passage through which the mixture of the aerosol and the gas is delivered to an outlet port of the nebulizer.

Abstract: A medicinal inhalation device having applied to a surface thereof a composition comprising a multifunctional polyfluoropolyether silane.

Abstract: A dry powder inhaler may include a powder storage, an inlet channel, a dispersion chamber, and an outlet channel. A geometry of the inhaler may be such that a flow profile is generated within the dispersion chamber that causes an actuator to oscillate, enabling the actuator when oscillating to deaggregate powdered medicament within the dispersion chamber to be aerosolized and entrained by the air and delivered to a patient through the outlet channel.

Abstract: A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

Abstract: A powder medicament mouthpiece comprising at least one section of through suction tube (1) and a filter (2). One end of the suction tube is a medicament inlet, and the other end (16a) is a suction outlet. The filter (2) is arranged within the suction tube (1). The powder medicament mouthpiece can be connected to multiple models of dry powder inhalers to separate powder medicament from dry powder, and allows for significantly improved efficacy.

Abstract: An apparatus, a closed-loop system and method for measuring the resistance of inhalation systems and/or devices are disclosed.

Abstract: Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose.

Abstract: A drug delivery apparatus of the type which releases a drug in aerosolized form into the inhaled airstream of a person, programmed to release the drug in a pulse which ends a pre-set time before the person is expected to stop inhaling. In doing so, a minimum residence time within the lungs is created, and drug treatment time can be reduced. A corresponding method of controlling a drug delivery apparatus comprises the step of controlling the apparatus to release the drug in aerosolized form into the inhaled airstream of a person in a pulse which ends a pre-set time before the person is expected to stop inhaling.

Abstract: The invention relates to a medicament magazine with a plurality of doses of medicament, wherein the magazine is formed from a single foil strip in which pouches (2) for holding a medicament are formed as depicted in exemplary FIG. 1. The foil strip comprises for transporting the strip openings (4) on at least one side for the engagement of transporting pins. The foil strip has a certain width in the region of the pouches, which is less than the width of the foil in other regions, and the openings are arranged in this broader part of the foil strip. The invention also relates to a method and a device for opening a medicament magazine of this kind, the device preferably being constructed as a segmented wheel.

Abstract: The invention provides improved devices for treating tracheobronchitis, bronchiectasis and pneumonia in intubated patients, with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment, the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The devices eliminate the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment also concentrates the therapeutic agent at affected sites in the lung such that therapeutic levels of administrated drug are achieved without systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this regimen.

Abstract: Provided are a medicine ejection device capable of realizing appropriate ejection by surely setting an inner pressure of a medicine tank at a negative pressure in an initial period of every ejection time, and a control method for the medicine ejection device. A medicine container section that contains medicine is coupled to a medicine ejection section including nozzles from which the medicine is ejected, and elements which generate energy for ejecting the medicine from the nozzles. A plug as a movable wall positionally shifts so that a capacity of the medicine container section can increase or decrease in accordance with a predetermined pressure difference between an inside and outside of the medicine container section. Prior to opening a head cap, the capacity is increased so as to generate pressure variations in a negative pressure direction, which have a larger value than a value equivalent to the predetermined pressure difference.

Abstract: Inhalation devices, systems, and methods for the administration of powdered medicaments to mechanically ventilated subjects are provided. In one embodiment, an inhalation device adaptively connected at one end to an air source and at the other end is operatively disposed to a ventilator circuit is provided. The inhalation devices are capable of causing a powdered medicament within a container held by the device to be dispensed from the container into the lungs of a mechanically ventilated subject.

Abstract: Dry powder formulations for inhalation comprising spray-dried particles and their use in the treatment of an obstructive or inflammatory airways disease. Each particle has a core of a first active ingredient in substantially crystalline form that is coated with a layer of a second active ingredient in substantially amorphous form that is dispersed in a pharmaceutically acceptable hydrophobic excipient. A process for preparing such formulations is also described.

Abstract: A liquid discharge head includes an energy generating element which generates energy to be used to discharge a liquid; and a plurality of discharge ports which is formed for each energy generating element and allows the liquid to be discharged therethrough. The plurality of discharge ports have regions where the angles of contact with the liquid are different around the discharge ports, and the regions in the discharge ports where the contact angles are relatively small are formed at different positions in the plurality of discharge ports, and the liquids discharged from the plurality of discharge ports are discharged in directions away from each other.

Abstract: An inhaler (1) for delivery of a powder-form inhalation formulation from a blister strip (2) with a plurality of blister pockets (3) is proposed. A tape is used for numbering.

Abstract: An inhaler comprising a housing defining a chamber to receive a strip having a plurality of blisters each containing a dose of medicament for inhalation by a user is disclosed. It comprises an actuating lever and a blister strip drive member rotatably mounted in the chamber to sequentially move each blister into a blister opening position. The blister strip drive member and the actuating lever comprise a drive gear and a drive gear element, respectively, that cooperate to effect rotation of the blister strip drive member in response to rotation of the actuating lever. The drive gear and drive gear element are disposed on the outside of the housing remote from the chamber.

Abstract: An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway.

Abstract: The invention provides compositions and methods for the prophylaxis or treatment of diseases or disorders in a subject (e.g., a mammal, such as a human) including, e.g., diseases or disorders caused by biological agents, autoimmune diseases, and cancer. The compositions include a delivery vector (e.g., a viral vector, such as an Ad5 vector) encoding an interferon (e.g., IFN-?), and are provided to the subject by, e.g., intranasal or pulmonary administration.

Abstract: A manifold for a medicament dispenser, where a manifold body defines a chimney with an inlet and an exit for directing airflow from the inlet to the exit, and a chamber with a chamber inlet and chamber exit. The chimney exit and the chamber inlet lie side-by-side each other such that when the open blister pocket of the blister pack is positioned adjacent thereto, the airflow may be directed from the chimney exit to the chamber inlet via the open blister pocket to entrain the medicament powder, enabling transport of powder in the airflow from chamber inlet to chamber outlet. The chimney creates turbulence in the airflow at the open blister pocket. The manifold comprises plural chimney exits, located at an angle relative to each other of from 150° to 30° such that, in use, plural airflow jets are directed at different and conflicting angles towards the open blister pocket.

Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container.

Abstract: An airflow adaptor for a breath-actuated dry powder inhaler. The airflow adaptor includes a conduit having a proximal end and a distal end, wherein the proximal end allows fluid communication from a deagglomerator outlet port to the distal end of the conduit, and wherein the airflow adaptor further includes provisions for allowing air to flow from a proximal end of the adaptor to a distal end of the adaptor independently of the airflow in the conduit when a breath induced low pressure is applied to the distal end of the airflow adaptor.

Abstract: The invention relates to a method of delivering an agent to the pulmonary system of a compromised patient, in a single breath-activated step, comprising administering a particle mass comprising an agent from an inhaler containing less than 5 milligrams of the mass, wherein at least about 50% of the mass in the receptacle is delivered to the pulmonary system of a patient. The invention also relates to receptacles containing the particle mass and the inhaler for use therein.