Abstract: A method for influencing and/or detecting magnetic particles in a region of action includes generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action. The method further includes changing the position in space of the two sub-zones in the region of action by means of a magnetic drive field so that the magnetization of the magnetic particles change locally, and acquiring signals that depend on the magnetization in the region of action. The magnetization is influenced by the change in the position in space of the first and second sub-zone. The magnetic drive vector of the magnetic drive field is rotated in at least one rotation plane.

Abstract: A system and method enables data to be communicated from a position within a human body to an external data device. The system includes a wireless communication module that is electrically coupled to an implant component having a metal surface so that the implant component operates as an antenna in response to the application of a modulated carrier wave being applied to the implant component. The wireless communication module may be coupled to the implant component so that the implant component operates as a monopole or dipole antenna. When the monopole configuration is used, the system further includes a ground plane so that the electromagnetic field emitted by the implant component is reflected and the emitted and reflected fields resemble the emitted field of a dipole antenna for the carrier frequency.

Abstract: Devices, systems, and methods provide accurate and consistent identification of the center of a magnetic infusion port.

Abstract: A navigation system or combination of navigation systems can be used to provide two or more types of navigation or modalities of navigation to navigate a single instrument. The single instrument can be positioned within the patient and tracked. For example, both an Electromagnetic (EM) and Electropotential (EP) navigation system can be used to navigate an instrument within a patient.

Abstract: A magnetic navigation control apparatus includes a sensing unit, a control unit and a magnetic field generating unit. The sensing unit generates a sensing signal according to the position of a magnetic element. The control unit is electrically connected with the sensing unit and generates a first control signal and a second control signal according to the sensing signal. The magnetic field generating unit is electrically connected with the control unit and has a housing, a plurality of interpoles, and a plurality of short poles. The interpoles are disposed in the housing. The short poles are disposed between the interpoles evenly. The magnetic field generating unit generates a navigation signal according to the first control signal, thereby controlling the magnetic element to move in at least one direction within a target region. The magnetic navigation control apparatus has greater magnetic navigation effects, and can thus reduce the cost.

Abstract: Improved assemblies, systems, and methods provide an implantable pulse generator for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination thereof. The implantable pulse generator is sized and configured to be implanted subcutaneously in a tissue region. The implantable pulse generator includes an electrically conductive case of a laser welded titanium material. Control circuitry is located within the case. The control circuitry includes a rechargeable power source, a receive coil for receiving an RF magnetic field to recharge the power source, and a microcontroller for control of the implantable pulse generator. The improved assemblies, systems, and methods also provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination thereof.

Abstract: An object of the present invention is to actively control at least one of the position and direction of the imaging field in a subject and to observe a desired observed region in the subject certainly in a short period of time. A body-insertable device system according to the present invention includes a capsule endoscope 1 introduced into a subject and a permanent magnet 3. An imaging unit of the capsule endoscope 1 for taking an image inside the subject is fixed in a casing. The capsule endoscope 1 includes a drive unit for changing at least one of the position and posture of the casing in the liquid 2a which is also introduced in the subject 100. The permanent magnet 3 controls the operation of the drive unit for changing at least one of the position and posture of the casing in the liquid 2a.

Abstract: Systems, methods, and devices providing for improved safety for an Intravascular Implantable Device (IID) are described herein. The IID includes a dislodgement detector that may include at least one accelerometer device and/or one or more microphones. In various embodiments, the accelerometer device is adapted to sense various forces or motions such that a dislodgement event may be detected. In one embodiment, the detector is adapted to sense movement of the IID through the vascular system as a result of dislodgement. In another embodiment, the detector is adapted to detect and compare accelerations caused by the force of gravity to determine a dislodgement event. In various embodiments, the detector includes a multi-axis accelerometer. In one such embodiment, the detector is adapted to detect an orientation of the IID in order to determine a dislodgement event.

Abstract: The present invention provides method and system for data communication in the human body and a sensor therefor. The method and system transmit information through the human body to a receiver located outside the human body using low current and voltage polarity, so that they cause no damage to the human body and achieve low power consumption and better receiving sensitivity. In addition, the sensor contains a CMOS image sensor on which all circuits are integrated without radio transmitter and antenna, so that it achieves a low-priced and small-sized capsule type endoscope.

Abstract: A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.

Abstract: A position detecting system includes a magnetic field generator, a detecting body, a magnetic field detector, a position/direction calculating unit, and a control unit. The magnetic field generator generates a magnetic field in a three-dimensional space. The detecting body is put into the three-dimensional space, and includes a resonance circuit for generating a resonance magnetic field. The position/direction calculating unit calculates a position/direction of the detecting body. If the resonance circuit is in the non-resonant state, the magnetic field detector detects an environmental magnetic field, and the control unit updates detection data of the environmental magnetic field. If the resonance circuit is in the resonant state, the magnetic field detector detects the spatial magnetic field in the three-dimensional space. The position/direction calculating unit executes processing using the detection data of the spatial magnetic field and updated detection data of the environmental magnetic field.

Abstract: Systems and methods for magnetically charging and discharging a member are disclosed. In certain embodiments, an external apparatus or internal device may comprise the member.

Abstract: An implantable medical device system includes an implantable device and an external locator device for percutaneously locating detecting port opening of the implantable device. The implantable device includes a port chamber forming the port opening, a septum sealing the port chamber relative to an exterior of the device, and a coil positioned at a known location relative to the port opening. The locator device includes a controller, at least one X-loop electrically coupled to the controller and oriented along a first major axis, and at least one Y-loop electrically coupled to the controller and oriented along a second major axis differing from the first major axis. The system is configured such that when the locator is spatially proximate the coil, an induced voltage in at least the Y-loop(s) is read by the controller to indicate a location of the coil relative to the locator device.

Abstract: A portable device for data communication using a body as a conductor to transmit data to a receiver, the portable device includes a data receiving unit to receive data, a controller unit to control processing of data to be transmitted, a current limiting circuit to limit a current of a signal corresponding to the data to be transmitted to a predetermined value, and transmitting electrodes connected to the current limiting circuit and to contact the body to transmit the signal having the current of predetermined value to the receiver.

Abstract: A method for position tracking includes receiving signals from a main position transducer at a distal end of a medical probe via wiring traversing the probe to a connector at a proximal end of the probe, for connection to a processor, which processes the signals to find a first position of the distal end. Calibration data with respect to an interference introduced into the signals at the connector is collected as a function of a position of the proximal end. A second position of an auxiliary position transducer at the proximal end of the probe is measured. The interference in the signals is canceled responsively to the measured second position and the calibration data. The first position is calculated based on the signals, after canceling the interference.

Abstract: Lung conditions are treated by implanting a flow restrictor in a passageway upstream from a diseased lung segment. The restrictor will create an orifice at the implantation site which inhibits air exchange with the segment to induce controlled atelectasis and/or hypoxia. Controlled atelectasis can induce collapse of the diseased segment with a reduced risk of pneumothorax. Hypoxia can promote gas exchange with non-isolated, healthy regions of the lung even in the absence of lung collapse.

Abstract: Surgical coils are disclosed for marking, anchoring, stapling and suturing. Such surgical coils may be implanted in the body by deforming them to a small cross section profile, sliding it them through a low profile delivery device then deploying them from an embodiment of a delivery device at a targeted site. Embodiments of surgical coils when deployed revert back to a coiled configuration and circle tissue at the target site. Such surgical coils may be deployed about attachment members, such as suture lines, marker lines and the like for anchoring same.

Abstract: A medical tube has one or more permanent passive integrated transponders associated therewith that are capable of being located by a detection apparatus which senses the electromagnetic field strength gradient generated by each passive integrated transponder associated with the medical tube and indicates the value of the gradient to the user. In one embodiment, the passive integrated transponder is associated with the distal end of an endotracheal medical tube in a fixed orientation with an electromagnetic field pointing at a preferred angle of no more than 15 degrees to the longitudinal axis of the medical tube. The passive integrated transponder's static electromagnetic field is sensed by the detection apparatus and indicates the location of the distal end of the medical tube within a body.

Abstract: A removable navigation system for a medical device configured for insertion within a lumen in a body is provided. The removable navigation system includes a sheath operatively configured to cover at least a portion of the medical device, a positioning sensor affixed to the sheath and a deformable fixation element disposed between the sheath and the medical device. The deformable fixation element is operatively deformed to temporarily fix a position of the medical device relative to the sheath and positioning sensor.

Abstract: A method for position tracking includes receiving signals from a main position transducer at a distal end of a medical probe via wiring traversing the probe to a connector at a proximal end of the probe, for connection to a processor, which processes the signals to find a first position of the distal end. Calibration data with respect to an interference introduced into the signals at the connector is collected as a function of a position of the proximal end. A second position of an auxiliary position transducer at the proximal end of the probe is measured. The interference in the signals is canceled responsively to the measured second position and the calibration data. The first position is calculated based on the signals, after canceling the interference.

Abstract: Apparatus and methods for implanting electronic implants within the body are described herein. Such electronic implants can include, for example, elongated stimulating devices, sensors and/or electronic leads. In some embodiments, an apparatus includes a first member and a second member operatively coupled to the first member. The first member has a proximal end portion and a distal end portion. The distal end portion of the first member includes a target probe. The second member has a proximal end portion and a distal end portion. The distal end portion of the second member is configured to be selectively coupled to an electronic implant.

Abstract: An anchor for a medical implant, methods of manufacturing the anchor, and procedures for placing a medical implant, such as for diagnosing, monitoring and/or treating cardiovascular diseases. The anchor has a base portion with first and second longitudinal ends and a cage therebetween. The anchor further has flexible arms, flexible legs, features for securing the medical implant within the cage of the base portion, and a coupler portion connected to and spaced apart from the second longitudinal end of the base portion. The anchor is adapted to have a deployed configuration in which the arms and legs radially project away from the base portion, the arms axially project toward the second longitudinal end of the base portion, and the legs axially project toward the first longitudinal end of the base portion. Convex surfaces of the arms and legs are adapted to clamp the anchor to a wall.

Abstract: A system operable to assist in a surgical procedure. The system can include a surgical navigation system that can be used to assist in determining a position of the surgical instrument, an information of an anatomical body, information regarding an anatomical structure, or combinations thereof. The system can further display the positional information or the anatomical or physiological information on a display.

Abstract: Medical devices and methods for magnetically positioning a device within a body cavity of a patient, including a removable magnet unit that can be reused across procedures.

Abstract: A position detecting apparatus includes receiving antennas to receive a radio signal, transmitting antennas to transmit a radio signal for power supply to a capsule endoscope, a first and second linear magnetic field generators that generate first and second linear magnetic fields, a diffuse magnetic field generator that generates a diffuse magnetic field, a processing device that performs a predetermined process on the radio signal, and a magnetic field sensor that functions as a body-size information detector. The magnetic field sensor detects magnetic field strength at an arranged position as body-size information, and the processing device controls the first linear magnetic field generator based on the magnetic field strength detected by the magnetic field sensor. Thus, the position detecting apparatus is capable of generating a magnetic field for position detection having an optimal strength according to a difference in body sizes of subjects.

Abstract: A system and method that facilitates multiple systems of communicating devices, i.e., a master device and one or more implantable slave devices, to coexist on a common, e.g., RF, communication channel having a limited temporal bandwidth while maintaining the required update rate between each master device and its associated slave devices. In embodiments of the present invention, master devices periodically transmit one or more beacon messages that are suitable for identification by other such master devices at a communication range greater than the communication range that may cause interference between systems and thus enabling one or more systems to cause the position of its frame periods to be interleaved with the frame periods of other such systems in anticipation of systems moving in closer proximity and actually interfering with each other.

Abstract: A position detecting apparatus includes a linear magnetic-field generator that generates a linear magnetic field in an area inside the subject; a diffuse magnetic-field generator that generates a diffuse magnetic field having position dependency on magnetic field direction in the area; a magnetic-field line orientation database in which a correspondence between magnetic field direction and position of the diffuse magnetic field in a reference coordinate axis is recorded; an orientation calculator that calculates orientation information of a body-insertable device introduced into a subject in the reference coordinate axis based on linear magnetic-field information and the earth magnetism direction; and a position calculator that calculates a magnetic field direction of the diffuse magnetic field at the position of the body-insertable device based on the linear magnetic-field information, orientation information, and diffuse magnetic-field information, and calculates the position of the body-insertable device b

Abstract: The invention provides methods and systems for determining the position of a remote object such as an in vivo medical device such as capsule or probe within a medical patient. The systems and methods of the invention may also be used in other enclosed environments such as fluid handling or mechanical systems. The systems and methods of the invention use one or more external magnetic sensor arrays for sensing the magnetic field of a remote object within a target area. The position of the object is determined by applying magnetic field spatial geometry characterization point analysis to evaluate the sensed magnetic field.

Abstract: An implantable microstimulator configured for implantation beneath a patient's skin for tissue stimulation to prevent and/or treat various disorders, uses a self-contained power source. Periodic or occasional replenishment of the power source is accomplished, for example, by inductive coupling with an external device. A bidirectional telemetry link allows the microstimulator to provide information regarding the system's status, including the power source's charge level, and stimulation parameter states. Processing circuitry automatically controls the applied stimulation pulses to match a set of programmed stimulation parameters established for a particular patient. The microstimulator preferably has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3 mm. A reference electrode is located on one end of the case and an active electrode is located on the other end.

Abstract: In general, the invention is directed to techniques for locating an implanted object using an external antenna. The implanted object may be, for example, an internal antenna that facilitates recharging of and/or communication with an implantable medical device. An external device coupled to the external antenna drives the antenna with a plurality of waveforms. Asymmetry in the loading profile of the external antenna when it is driven by the plurality of waveforms allows the external device or another device to determine the location of the implanted object relative to the external antenna. The external device or other device may provide information to a user based on the determined location of the implanted object relative to the external antenna, such as information to help a user position the external antenna with respect to an internal antenna in embodiments in which the implanted object is an internal antenna.

Abstract: The invention is directed toward a magnetic indicator tool used to determine the setting of an implantable medical device. The implantable medical device includes a magnetic indicator device coupled to a valve on the implantable medical device. External magnetic fields, specifically earth's magnetic field, may interfere with a conventional compass and create an incorrect device setting indication. The magnetic indicator tool estimates the external magnetic fields to subtract the estimate from received data to minimize any influence that external magnetic field has on the accuracy of the device setting measurement.

Abstract: A medical device communications network comprises a plurality of medical devices including either or both of a first number of surgical instruments and a second number of implants configured for subcutaneous implantation in a biological body. A corresponding plurality of wireless communication circuits are each mounted to a different one of the plurality of medical devices. Each of the plurality of wireless communication circuits is configured to broadcast medical device information relating to the medical device to which it is mounted and to receive information relating to any other of the plurality of medical devices. The network may or may not include a master wireless communications circuit configured to receive the medical device information broadcast by any of the plurality of slave wireless communication circuits and to broadcast the information relating to any other of the plurality of medical devices.

Abstract: In one embodiment, a pressure sensing system is described which transmits data to a patient management system external to a patient. The pressure sensing system can rigidly couple to an implantable port or flexibly couple to an implantable port. In some embodiments, the pressure sensing system communicates with a hydraulic actuating system. In some embodiments, the pressure sensing system is implantable and comprises a circuit capable of wireless transmission through the skin of a patient to an external receiver which is part of a patient management system. A patient management system is described which receives up to date as well as historical data from the pressure sensing system and manages the these data in the context of a patient database.

Abstract: The movement of magnetically responsive nanoparticles through a membrane is significantly enhanced by using a varying magnetic field gradient. The magnetic field varies in intensity and/or direction and can be achieved by mechanically varying the position of a magnet with respect to the membrane, or by oscillating the strength of one or more electromagnets.

Abstract: A method for assessing functionality of a valve in a heart includes providing a position sensor that is a wireless transponder for transmitting or receiving an ultrasound wave for determination of position coordinates of the position sensor at the point; implanting the wireless transponder at a point on the valve; and using a position determining system for determining whether the valve is functioning properly based on position coordinates of the wireless transponder.

Abstract: A system is provided comprising an optically-guided catheter having a proximal end, a distal end, and at least one lumen. A light-emitting means is coupled to the catheter, the catheter is inserted into place in the patient, and light is emitted as a point or points from a selected location, usually the distal tip, of the catheter to which it is coupled. The system further comprises an external detection device that detects the transdermally projected light, emitted by the light-emitting point from within the patient, thereby indicating precise placement of the catheter within the patient.

Abstract: Methods for cleaning and limiting the extent of adhesives are disclosed. For example, a method for cleaning adhesive near a surgical site in a patient's body comprises the acts of dispensing a magnetic adhesive at a desired location at the surgical site, and applying an external magnetic field that removes a portion of the magnetic adhesive from the body of the patient outside of the desired location.

Abstract: A vaginal probe includes a metal detection sensor for detecting the presence of ferrous-laden endometriotic tissues. The probe is electrically connected to external electronic circuitry for interpreting the readings taken by the sensor and for providing a qualitative or quantitative measurement of the amount of endometriotic tissues present. The probe is inserted in either the vagina or peritoneal cavity of a patient to detect the location and the relative amounts of iron or ferrous-laden tissues in the pelvic area of the patient. Using the probe and monitoring the readings over time as part of pelvic exams assists in determining the early onset or progression of endometriosis and/or the response to one or more therapies being provided to the patient to treat the disease.

Abstract: In the present invention, because no examples are known of binding of magnetic particle to mesenchymal cell or chondrocyte which might be used in regenerative medicine, whether or not a cell having the magnetic particle bound thereto is retained in local by external magnetism after administration and whether or not the cell can exhibit intrinsic activity is studied. According to the present invention, a magnetic cell comprising mesenchymal cell or cultured chondrocyte having magnetic particle bound to the surface thereof is provided, and when the cell is administered in vivo and an external magnetic field is applied, the cell can be retained for a long time at a disease site. Moreover, a drug delivery system can be constructed by causing the magnetic cells to contain a drug.

Abstract: A system for magnetically navigating a medical device in an operating region within the body of a patient. The system includes a magnet having a front field projecting from the front of the magnet sufficient to project a magnetic field into the operating region in the patient. The magnet is mounted for movement between a navigation position in which the magnet is located adjacent to the patient with the front of the magnetic generally facing the operating region, and an imaging position in which the magnet is spaced from the patient and the front generally faces away from the operating region.

Abstract: A method includes inserting a target probe along a first path within a body such that a portion of the target probe is disposed adjacent a target location within the body. The target location can be, for example, a portion of a nerve, a muscle or the like. An electronic implant is inserted along a second path within the body such that a portion of the electronic implant is disposed adjacent the target location within the body. The second path is different from the first path. The electronic implant is inserted when the target probe is disposed adjacent the target location within the body.

Abstract: In one embodiment, an external programming device is operable to determine and graphically display power consumption of an implantable medical device (“IMD”). In accordance with this particular embodiment, the external programming device includes a graphical user interface display and a communication interface operable to receive information from an IMD. In this embodiment, the external programming device is operable to receive IMD parameter settings and/or battery parameter values from the IMD, calculate a power consumption rate for the IMD, and then display the power consumption on the graphical user interface display using a graphical visual indicator.

Abstract: A marker delivery device is described which has an obturator with an elongated shaft, an inner lumen, a proximal end, and a substantially sealed distal end. One or more tissue markers are deployed within the inner lumen of the elongated shaft of the obturator. Preferably, the tissue marker(s) is disposed within an inner lumen of a marker delivery tube which is disposed within the inner lumen of the elongated shaft of the obturator. The marker delivery tube has an opening for discharging the tissue markers into a body (e.g. biopsy) cavity. The distal tip of the marker delivery tube is configured to penetrate the substantially sealed distal end of the obturator so that tissue markers can be delivered while the obturator is in place within the body. Preferably, the obturator includes a detectable element capable of producing a relatively significant image signature during MRI.

Abstract: Implantable medical device telemetry is provided between an implantable medical device and an external communication device. The implantable medical device includes a device transmitter and/or a device receiver. The external communication device includes a moveable communication head including an antenna therein connected to at least one of an external transmitter and/or an external receiver for communication with the device transmitter and/or the device receiver of the implantable medical device. A user moves the moveable head apparatus relative to the implantable medical device. Tactile feedback is provided to the user via the moveable head apparatus upon movement of the moveable head apparatus to a position where valid telemetry can be performed.

Abstract: Methods and devices are disclosed for manipulating the tongue, and more particularly for temporarily suspending the tongue. One embodiment of the device comprises an elongate member with a retractable distal tissue-engaging tip that is movable within the lumen of tubular member configured for insertion into the tongue, preferably from an inferior surface of the jaw. The device may be used diagnostically assess the effect of performing tongue suspension in a patient prior to permanent implantation of a glossopexy device. The retractable distal tissue-engaging tip may be removed after diagnostic assessment, or left in place and attached to a temporary external securing device.

Abstract: Embodiments of the invention are directed to an apparatus for use in a system that senses an excitable wireless target capable of being implanted in a body or tissue. The apparatus includes multiple electromagnetic field sensors arranged approximately in a common plane, and multiple sense signal output paths coupled to the sensors. Each one of the sensors and corresponding output paths is configured to provide an output signal representing at least a portion of an electromagnetic field provided by the marker, where the output signal is proportional to a component of the field at the sensor, where that component is substantially perpendicular to the plane. Various other configurations regarding this apparatus, as well as the overall system and methods of exciting and receiving signals from wireless markers, are also disclosed.

Abstract: The invention proposes a device for mechanically locating and reading the setting of an adjustable magnetic valve for controlling the flow of a fluid in a predetermined direction to locate the magnetic centre of the valve and to determine the setting of the valve. The device comprises a magnetic compass (10), an alignment mark for aligning the magnetic compass (10) with respect to the direction in which the fluid flows, a reference plane (Pr), and a magnetic indicator (12), which is mounted such that it can pivot in all three dimensions of space under the effect of the magnetic field of the valve. The magnetic indicator (12) includes at least one magnet capable of receiving a magnetic field and having a north-south direction, wherein the north-south direction is substantially perpendicular to the reference plane (Pr) when the magnetic indicator (12) is positioned substantially perpendicular to the reference plane (Pr).

Abstract: Medical systems and methods are provided for accessing a bodily cavity, such as the peritoneal cavity or the thoracic cavity, and for supporting diagnoses or procedures within or adjacent to such cavities. According to one embodiment, a method is provided for accessing an internal bodily cavity of patient, the bodily cavity defined by a cavity membrane, the patient having multiple tissue layers adjacent the bodily cavity including at least a skin layer and a fascia layer. An opening is formed through the skin layer and the fascia layer. An elongate medical device is inserted through the opening and between the fascia layer and the cavity membrane to form a tunnel communicating with the opening. Various medical instruments may then be used within the tunnel, and related medical kits and systems are described.

Abstract: An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed. The airway implant device includes a deformable element to control the opening of an air passageway and a tether. Preferably the deformable element is an electroactive polymer element. Energizing of the electroactive polymer element provides support for the walls of an air passageway, when the walls collapse, and thus, completely or partially opens the air passageway.

Abstract: A method for forming at least a part of a preferably endovascular interventional aid with the aid of self-organizing nanorobots consisting of catoms and an associated system are provided. A form of the required interventional aid is determined from at least one 3D image data record of a target region. The determined form is converted to a readable and executable program code for the respective catoms of the nanorobots and is transferred to a storage unit. The program code is executed which prompts self-organization of the previously unstructured catoms to form the required interventional aid according to the previously determined form.