Abstract: The present invention provides a micro-robot for use inside the body during minimally-invasive surgery. The micro-robot includes an imaging devices, a manipulator, and in some embodiments a sensor.

Abstract: A device configured for implanting beneath a patient's skin for the purpose of tissue, e.g., nerve or muscle, stimulation and/or parameter monitoring and/or data communication. Devices in accordance with the invention are comprised of a sealed housing, typically having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mm, having a non-circular, e.g., an oval or polygon shaped, cross-section containing a power source for powering electronic circuitry within including a controller, an address storage means, a data signal receiver and an input/output transducer. When used as a stimulator, such a device is useful in a wide variety of applications to stimulate nerves and associated neural pathways. Alternatively, devices of the present invention are configurable to monitor a biological parameter. Furthermore, a placement structure is shown for facilitating placement of the implantable device proximate to neural/muscular tissue.

Abstract: A system for treating sleep-related breathing disorders. In one embodiment, the system includes a first magnetically susceptible material attached to a left lateral pharyngeal wall and a second magnetically susceptible material attached to a right lateral pharyngeal wall. The second magnetically susceptible material is positioned opposite the first magnetically susceptible material across an upper airway. The system further includes a first magnet disposed outside the body and lateral to the first magnetically susceptible material, and a second magnet disposed outside the body and lateral to the second magnetically susceptible material.

Abstract: An improved catheter is provided that is particularly useful for mapping the Purkinje fibers for potential diagnosis of ventricular fibrillation. The catheter comprises an elongated catheter body having proximal and distal ends and at least one lumen extending longitudinally therethrough. Mounted at the distal end of the catheter body is a mapping assembly having at least two spines, each having a proximal end attached at the distal end of the catheter body and a free distal end. Each spine comprises at least one electrode, preferably a tip electrode and at least one ring electrode. An irrigation tube extends through the catheter body and has an open distal end that is in communication with the outside of the distal end of the catheter body. The spines may be arranged in an expanded arrangement wherein each spine extends radially outwardly from the catheter body or in a collapsed arrangement wherein each spine is disposed generally along the longitudinal axis of the catheter body.

Abstract: The present invention is generally directed towards an imaging transducer assembly. Generally, the imaging transducer assembly is combined with a sensor of a medical positioning system. In one aspect, the transducer assembly and the sensor share the same voltage source. In another aspect of the invention, the sensor surrounds a portion of the imaging transducer assembly, forming a housing that reinforces the assembly.

Abstract: A system and method of controlling movement of magnetic material with at least first and second high temperature superconductors at spaced locations. A plurality of solenoids are associated with the superconductors to induce a persistent currents in preselected high temperature superconductors establishing a plurality of magnetic fields in response to pulsed currents introduced to one or more of the solenoids. Control mechanism in communication with said solenoids and/or said high temperature superconductors are used to demagnetize selected ones of the high temperature superconductors to reduce the magnetic fields substantially to zero. Magnetic material is moved between magnetic fields by establishing the presence thereof and thereafter reducing magnetic fields substantially to zero and establishing magnetic fields in other superconductors arranged in a predetermined configuration.

Abstract: A device for configuring a body insert, such as an electrode lead for a stimulation device, has a wire arrangement adapted to be inserted into the interior of the body insert for stiffening and bending the body insert. The wire arrangement has a tip section which, when the wire arrangement is inserted in the body insert, resides at the distal end thereof. The tip section has a bendable insulating polymer element which contains a number of bending actuators connected in series. The bending actuators are formed by successive silicon sections interconnected by polyimide-filled V-groove joints in thermal communication with a heating element. The operation of the heating element from a regulation unit adapted for access at a proximal end of the body insert controls expansion of the polyimide filling the joints, thereby producing a selected amount of bending at the tip section and the distal end section of the body insert.

Abstract: The present invention provides a micro-robot for use inside the body during minimally-invasive surgery. The micro-robot may include various sensors, imaging devices or manipulators.

Abstract: A system for measuring the position of an in vivo radio device is disclosed. The system comprises the in vivo radio device administered into a living organism, a plurality of ex vivo radio devices disposed outside of the living organism, and a position measuring device. The in vivo radio device includes a transmitter for transmitting a vital information signal or a position measuring signal. Each of the ex vivo radio devices includes a receiver for receiving the vital information signal or the position measuring signal. The position measuring device includes a position measuring unit for measuring the position of the in vivo radio device based on receiving characteristics of the vital information signal or the position measuring signal received by the ex vivo radio devices.

Abstract: A method and apparatus for alleviating or curing human afflictions, ailments and diseases holistically by application of magnetism. A north pole surface of a magnet is applied to a portion of the extremities, about 990 square inches' of the upper extremities and 1800 square inches of the lower extremities, of a person being treated, and is maintained in contact for a time period or periods in accordance with total flux applied for the afflictions or ailments being treated. The magnet is maintained in contact for a time period or periods sufficient to elicit holistic effect of alleviation or cure and to detect ailments and cure in progress or a balanced treatment point. Magnet is being configurated to accommodate the area being treated and having appropriate total flux.

Abstract: The present invention 10 provides a system and method of monitoring and tracking a plurality of physical variables from a remote location. The invention 10 utilizes a plurality of radio frequency identification transponders 20 each coupled with a sensor for measuring physical data. The transponders 20 are powered by a radio frequency reader/interrogator 60 that provides radio frequency excitation to the transponders 20 and receives and demodulates back-scattered signals therefrom. The invention 10 is particularly advantageous in monitoring temperature in cattle herds as an aid to early diagnosis of bovine respiratory disease.

Abstract: A receiver for determining the location of a marker that is excited with an exciting waveform. A sensing array having coils is used to sense magnetic flux from the resonating marker. The coils provide inputs to the receiver. The receiver includes a correlation processor for analyzing the inputs in a coherent manner. Further, the exciting waveform is repeated with random dithering in order to eliminate system noise.

Abstract: A food intake restriction apparatus and method includes and uses an operable restriction device implanted in a patient and engaging the stomach or esophagus to form an upper pouch and a restricted stoma opening in the stomach or esophagus. A source of energy external to the patient's body and a control device for releasing wireless energy from the source of energy from outside the patient's body are provided. The released wireless energy is used in connection with the operation of the restriction device, to enlarge it to allow food passage, or to contract it to substantially prevent food passage.

Abstract: A system for magnetically navigating a medical device in an operating region within the body of a patient. The system includes a magnet having a front field projecting from the front of the magnet sufficient to project a magnetic field into the operating region in the patient. The magnet is mounted for movement between a navigation position in which the magnet is located adjacent to the patient with the front of the magnetic generally facing the operating region, and an imaging position in which the magnet is spaced from the patient and the front generally faces away from the operating region.

Abstract: A method of navigating a medical device having a changeable magnetic moment within an operating region within a patient, the method includes applying a navigating magnetic field to the operating region with an external source magnet, and changing the direction of the magnetic moment in the medical device to change the orientation of the medical device in a selected direction within the operating region. The magnet moment of the medical device can be created by one or more electromagnet coils, in which case the magnetic moment can be changed by changing the current to the coil. Alternatively, the magnetic moment of the medical device can be created by one or more permanent magnets, in which case the magnetic moment can be changed by mechanically or magnetically manipulating the permanent magnet.

Abstract: An apparatus and method for locating a magnetic implant in a surgical application using the field of a source magnet for the implant guiding field. The source magnet is an electromagnet having a separate calibrated magnetic field component in addition to the guiding field, so that both the magnitude and orientation of the magnetic field as a function of position around the magnet are known. A magnetic implant is provided with a sensor, such as a three-axis Hall effect sensor, to provide an indication of the magnitude and orientation of an applied magnetic field when the implant is surgically implanted in a patient. After implantation, the source magnet is energized with a current having a modulated component. The modulated component is received and filtered from the signal received from the Hall effect sensor in the implant, and provided to a processor that computes the location of the implant.

Abstract: A system and method for image guided instrument targeting including a robot unit coupled with an instrument, an imaging unit, and a first control unit, which is coupled with the robot unit and coupled with the imaging unit. The control unit receives the imaging data about a target and about the instrument from the imaging unit and controls the robot unit to properly orienting the instrument for insertion, based upon the imaging data.

Abstract: An integrated surgical anchor/localization sensor is disclosed. The anchor is adapted to be secured to an anatomical structure and contains a sensor housing. A receiver is located within the sensor housing and is adapted to sense reference signals generated by a surgical guidance system. A transmitter, connected to the receiver, conveys to a processor signals received by the receiver, so that the signals transmitted by the receiver are indicative of a current position of the anchor. Various other structures and methods are also disclosed.

Abstract: A clip and a bioabsorbable marker are employed to mark a biopsy site. The former provides a permanent marker that is clamped onto tissue and that cannot migrate from the site over time. The latter is gradually bioabsorbed over time but the time may vary widely from weeks to months. In most embodiments, the clip and marker are integrally formed with one another at the time of manufacture. In one embodiment, the clip and marker are independently made but are joined to one another during the site-marking process. The markers are deployed by core biopsy needles of the type employing a vacuum, of the type that does not employ a vacuum, and by coaxial biopsy needles.

Abstract: A method for performing a procedure at the fossa ovalis in the septal wall of the heart includes the steps of providing a sheath having a body wherein the body has a lumen extending therethrough and an open end at the distal end of the body. The body also has at least one electrode and a position sensor at the distal end of the body. The position sensor generates signals indicative of the location of the distal end of the body. The sheath is navigated to the septal wall using the position sensor and the fossa ovalis in the septal wall is identified using the at least one electrode of the sheath.

Abstract: An electrophysiology catheter includes a tube having a proximal end, a distal end, and a lumen therebetween. The tube is preferably comprised of multiple sections of different flexibility, arranged so that the flexibility of the catheter increases from the proximal end to the distal end. There is a first generally hollow electrode member at the distal end. At least one magnetically responsive element is disposed at least partially in the hollow electrode, for orienting the distal end of the catheter with an externally applied magnetic field. Multiple magnets can be distributed over the distal portion of the device. The end electrode can have openings for delivering irrigating fluid, and/or a sleeve can be provided around the tube to create an annular space for the delivering of irrigating fluid. A temperature sensor can be provided to control the operation of the catheter. A localization coil can also be included to sense the position and orientation of the catheter.

Abstract: Two minimally invasive therapeutic procedures, particularly for patients with congestive heart failure, may be performed separately or together. One procedure involves providing a valved passageway through the patient's left ventricular wall at the apex of the patient's heart and advancing instruments through the valved passageway to connect the valve leaflets of the patient's heart valve, e.g. the mitral valve. The second procedure involves advancing a pacing lead and a pacing lead implanting device through a trocar in the patient's chest and implanting the pacing lead on an exposed epicardial region of the patient's heart wall. The pacing lead has a penetrating electrode which is secured within the heart wall. Improved devices for these procedures include a minimally invasive grasping device for heart leaflets, a leaflet connector with artificial cordae tendenae and a pacing lead implant instrument.

Abstract: A catheter is provided that has a basket-shaped electrode assembly with an improved mechanism for expanding and contracting the electrode array. The expansion mechanism is designed to permit reproducible reintroduction of the catheter into the heart. The catheter comprises an elongated catheter body having at least one lumen therethrough. A basket-shaped electrode assembly is mounted at the distal end of the catheter body. The basket assembly comprises a plurality of spines connected at their proximal and distal ends, each of which comprises at least one electrode. The basket assembly has an expanded arrangement wherein the spines bow radially outwardly and a collapsed arrangement wherein the spines are arranged generally along the axis of the catheter body. An expander is attached at or near its distal end to the distal ends of the spines and extends through the catheter body. The expander has a proximal end that extends out the proximal end of the catheter body a lumen extending therethrough.

Abstract: A method is provided for electrical mapping of a pulmonary vein of a heart, including introducing into the heart a catheter having a curved section and a base section, the base section having a distal end attached to a proximal end of the curved section. At a location on the curved section, a first position signal is generated having fewer than six dimensions of position and orientation information. At a vicinity of the distal end of the base section, a second position signal is generated having six dimensions of position and orientation information. The method also includes measuring, at one or more locations on the curved section, an electrical property of the pulmonary vein.

Abstract: An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.

Abstract: A method of localizing a device, medical or otherwise, within a three dimensional environment, the method comprising: (a) transmitting time varying magnetic fields from at least three transmitters, (b) receiving the transmitted electromagnetic radiation as induced voltage signals from at least one receiver mounted on or within said device, and (c) a processing scheme for processing said received voltage signals in order to extract position and orientation localization information for said device, said processing scheme including correction for conducting materials in the vicinity by the use of information gathered from at least three distinct transmission frequencies for each of said transmitters.

Abstract: An improved basket catheter is provided that is particularly useful for mapping the heart. The catheter comprises an elongated catheter body having proximal and distal ends and at least one lumen therethrough. A basket-shaped electrode assembly is mounted at the distal end of the catheter body. The basket assembly has proximal and distal ends and comprises a plurality of spines connected at their proximal and distal ends. Each spine comprises at least one electrode. The basket assembly has an expanded arrangement wherein the spines bow radially outwardly and a collapsed arrangement wherein the spines are arranged generally along the axis of the catheter body. The catheter further comprises a distal location sensor mounted at or near the distal end of the basket-shaped electrode assembly and a proximal location sensor mounted at or near the proximal end of the basket-shaped electrode assembly.

Abstract: An implantable medical device, perhaps a pacemaker lead, has a medical unit and a casing at least partially enclosing the medical unit. The casing is formed of a base polymer having surface modifying pendant groups formed of an acrylamide polymer or an acrylamide copolymer, perhaps polyisopropyl acrylamide. The base polymer may be a polyurethane, polyimide, fluoropolymer or polyolefin, for example.

Abstract: A magnetic resonance imaging system for interventional MR imaging involves operations to insert a device such as a catheter into an object. According to the system, a tip position of the catheter is detected, data indicative of moved loci of the catheter are produced from data indicative of the detected tip position, and the produced movement locus data are displayed. In addition, even when an operator changes the progress direction of the device such as a puncture needle, an imaging cross-section automatically tracks movements of the device. Appropriate preoperative planning is also provided.

Abstract: A system and method for displaying implantable medical device data that includes translating means for translating data written in a first predetermined format that is not compatible with SVG-formatted data into SVG-formatted data, and formatting means for receiving the SVG-formatted data and for providing a user-comprehensible representation of the SVG-formatted data. In this way, session data is converted from a first format to a second format, and the converted session data is rendered to enable multiple display and control of the converted session data so that the rendered data is displayed using the multiple display and layout control to provide a user with multiple display of a single set of session data.

Abstract: Atherectomy devices are guided by and manipulated by externally applied magnetic fields to treat total or partial occlusions of a patient's vasculature.

Abstract: A permanent magnet housed in a porous metal container is implanted in the pelvis of a subject and a second permanent magnet is attached to a supporting structure, such as the seat of a wheelchair. The opposing force produced by the two magnets when the subject rests on the supporting structure reduces the compressive force acting on the tissues therebetween.

Abstract: The invention concerns a method for determining the filling of a lung, wherein the movement of an anatomical structure which moves with breathing, or one or more points on the moving anatomical structure whose movement trajectory is highly correlated with lung filling, is detected with respect to the location of at least one anatomical structure which is not spatially affected by breathing, and wherein each distance between the structures is assigned a particular lung filling value.

Abstract: The invention is directed toward a magnetic shield included in a compass-based indicator tool. The indicator tool utilizes a compass to indicate a device setting of an implantable medical device. The implantable medical device may include a target that creates an internal magnetic field for the compass to interact with. External magnetic fields, specifically earth's magnetic field, may interfere with the compass and create an incorrect device setting indication. The magnetic shield blocks the external magnetic fields from influencing the accuracy of the device setting measurement.

Abstract: An ionically conductive polymeric composition is disclosed. The composition is especially useful for coating an implantable hot can defibrillator electrode. The polymeric composition, for example, polyethylene oxide containing NaCl or a similar ionic medium, can be used to coat and fill the pores of a high surface area electrode to provide a continuous ionic network from the can to the adjacent body tissue. The conductive polymeric composition is biocompatible, chemically and mechanically stable and does not dissolve or leach out over the useful lifetime of the defibrillator. A hot can defibrillator employing the polymeric coating avoids development of high polarization at the can/tissue interface and maintains a more uniform defibrillation threshold than conventional implantable defibrillators, thus increasing the feasibility of pectoral implantation, particularly in a “dry pocket” environment.

Abstract: An electrophysiology catheter includes a tube having a proximal end, a distal end, and a lumen therebetween. The tube is preferably comprised of multiple sections of different flexibility, arranged so that the flexibility of the catheter increases from the proximal end to the distal end. There is a first generally hollow electrode member at the distal end. A magnetically responsive element is disposed at least partially in the hollow electrode, for aligning the distal end of the catheter with an externally applied magnetic field. The end electrode can have openings for delivering irrigating fluid, and/or a sleeve can be provided around the tube to create an annular space for the delivering of irrigating fluid. A temperature sensor can be provided to control the operation of the catheter. A localization coil can also be to sense the position and orientation of the catheter.

Abstract: A detachable support arm structure couples a computer-assisted navigation system reference array to an instrument, for example, a surgical instrument, such that the geometry between the reference array and the surgical instrument is predetermined and registration of the instrument in the navigation system does not require calibration each time the reference array and support arm structure is coupled to the instrument. The support arm structure includes a mounting interface engageable with a mounting interface on the instrument. Engagement of the mounting interfaces releasably secures and repeatably and accurately locates and fixes the support structure to the instrument in a predefined geometry in each of six degrees of freedom.

Abstract: A metal detection apparatus for detecting a metal object (13) beneath a surface (12a) of a human or animal body (12) comprises transmitter means (10) for generating a magnetic field in the vicinity of the metal object (13), thereby inducing currents within the metal object (13) to generate a secondary magnetic field, and detection means (14) for detecting the secondary magnetic field.

Abstract: A device for generating an artificial constriction in the gastrointestinal tract comprises a band (1), which can be placed annularly about a particular portion of the gastrointestinal tract, and a closure device (2) for connecting the end regions of the band (1) placed annularly about a portion of the gastrointestinal tract, the band in the closed state of the closure device (2) encompassing a throughlet opening (6), the band (1) including a hollow chamber (13) fillable with a filling medium and extending at least over a large portion of the length of the band (1) and delimited on its side, facing the throughlet opening (6), by a diaphragm (11), by means of which the size of the throughlet opening (6) can be decreased by filling the hollow chamber (13).

Abstract: A switch such as a normally closed MEMS switch may be used in an in-vivo device to alter a mode or operation; for example, to disconnect the power unit from electrical circuitry during storage of the in-vivo device by introducing a magnetic field in the proximity of the in-vivo device. The in-vivo de vice may be powered by removing the magnetic field upon use. Other switches, such as normally open switches, or switches including multiple sets of leads, having multiple functionality, may be used. A packaging generating a magnetic field may operate the switch when the device is in the packaging.

Abstract: An apparatus is disclosed for detecting a wireless energy receiving device subcutaneously implanted in a patient's body to enable accurate positioning of a wireless energy transmission device outside the patient's body relative to the energy receiving device. Also disclosed is a method for detecting the wireless energy receiving device whereby an energy transmission device can be positioned to efficiently transmit wireless energy to the implanted energy receiving device. The apparatus includes a magnetic device that is subcutaneously implanted in the patient adjacent to the energy receiving device to emit a local magnetic field through the patient's skin adjacent to the energy receiving device. A magnetic detector movable externally along the patient's body is capable of detecting the local magnetic field emitted by the magnetic device. This allows the energy transmission device to be located for the efficient transmission of wireless energy to the implanted energy receiving device.

Abstract: An apparatus and method for the detection of objects in the work area such as surgical sites, including a detection tag affixed to objects such as used during surgery. The apparatus and method feature an interrogation and detection device with a transmitter for emitting pulsed wideband signals each including a signal prompting the tag element to provide a return signal, and a receiver for reception and analysis of the return signal from the tag element. Multiple pulse signals (of constant or varied height) emitted from the transmitter causes the return signals to build up in intensity at a detectable frequency above the ambient noise levels to facilitate detection of the tag element and object attached thereto. The device features an antenna portion containing a single or a plural ring-shaped antenna. Also, the pulsed wideband interrogation signal may be pulsed-width modulated or voltage-modulated, as two examples thereof.

Abstract: An electrophysiology catheter includes a tube having a proximal end, a distal end, and a lumen therebetween. The tube is preferably comprised of multiple sections of different flexibility, arranged so that the flexibility of the catheter increases from the proximal end to the distal end. There is a first generally hollow electrode member at the distal end. At least one magnetically responsive element is disposed at least partially in the hollow electrode, for orienting the distal end of the catheter with an externally applied magnetic field. Multiple magnets can be distributed over the distal portion of the device. The end electrode can have openings for delivering irrigating fluid, and/or a sleeve can be provided around the tube to create an annular space for the delivering of irrigating fluid. A temperature sensor can be provided to control the operation of the catheter. A localization coil can also be included to sense the position and orientation of the catheter.

Abstract: A medical transponder, including an ultrasonic sensor that detects impinging ultrasonic waves and generates electrical signals in response thereto; an electrical connection which receives said signals; and an electromagnetic RF transmitter coupled to said electrical connection and which generates an RF signal in response to said detected waves.

Abstract: A method of placing a pacing lead in the heart includes introducing a distal end of a delivery catheter into the patient's vasculature; magnetically navigating the distal end of the delivery catheter to the patient's heart; deploying a pacing lead from the distal end of the delivery catheter; and magnetically navigating the pacing lead to the pacing application site.

Abstract: A method for performing a procedure at the fossa ovalis in the septal wall of the heart includes the steps of providing a sheath having a body wherein the body has a lumen extending therethrough and an open end at the distal end of the body. The body also has at least one electrode and a position sensor at the distal end of the body. The position sensor generates signals indicative of the location of the distal end of the body. The sheath is navigated to the septal wall using the position sensor and the fossa ovalis in the septal wall is identified using the at least one electrode of the sheath.

Abstract: A system for measuring the position of an in vivo radio device is disclosed. The system comprises the in vivo radio device administered into a living organism, a plurality of ex vivo radio devices disposed outside of the living organism, and a position measuring device. The in vivo radio device includes a transmitter for transmitting a vital information signal or a position measuring signal. Each of the ex vivo radio devices includes a receiver for receiving the vital information signal or the position measuring signal. The position measuring device includes a position measuring unit for measuring the position of the in vivo radio device based on receiving characteristics of the vital information signal or the position measuring signal received by the ex vivo radio devices.

Abstract: A distance measuring system comprises first and second transducers, and an ultrasound ranging subsystem coupled to the first and second transducers for performing a plurality of distance measurements between the first and second transducers. The distance measurement system can have various applications, including medical applications, in which case, the first and second transducers can be mounted on a catheter. The distance measuring system further comprises a filter coupled to the ultrasound ranging subsystem for filtering ultrasound interference from the plurality of distance measurements (such as, e.g., eight), and outputting a distance based on the filtered distance measurements. The filter filters the ultrasound interference by selecting one of the plurality distance measurements, in which case, the outputted distance is the selected distance measurement.

Abstract: A method of turning a medical device, having a magnetically responsive element associated with its distal end, at an operating point within an operating region inside a patient's body from an initial direction to a desired final direction, through the movement of at least one external source magnet. The at least one external source magnet is moved in such a way as to change the direction of the distal end of the magnetic medical device from the initial direction to the desired final direction without substantial deviation from the plane containing the initial direction and the desired final direction.

Abstract: The present invention is generally directed towards an imaging transducer assembly. Generally, the imaging transducer assembly is combined with a sensor of a medical positioning system. In one aspect, the transducer assembly and the sensor share the same voltage source. In another aspect of the invention, the sensor surrounds a portion of the imaging transducer assembly, forming a housing that reinforces the assembly.