Abstract: An implantable marker, instruments for implanting the marker and method for implanting the marker are described. The implanta+e marker comprises a housing with an outer surface providing a bone anchor and having a cavity within which a marker detectable by a tracking system is secured. The kit includes a guide instrument having a guide channel for receiving an implanta+e marker, an insertion tool receivable within the channel and having a distal end for releasably engaging an implanta+e marker, and an implanta+e marker receiva+e within the channel. The insertion tool is operable to drive the implanta+e marker into the bone. The method includes puncturing the skin with an instrument, driving the implanta+e marker into the bone and withdrawing the instrument, leaving the marker implanted within the bone.

Abstract: A method of communicating with an ingestible capsule includes detecting the location of the ingestible capsule, focusing a multi-sensor acoustic array on the ingestible capsule, and communicating an acoustic information exchange with the ingestible capsule via the multi-sensor acoustic array. The ingestible capsule includes a sensor that receives a stimulus inside the gastrointestinal tract of an animal, a bidirectional acoustic information communications module that transmits an acoustic information signal containing information from the sensor, and an acoustically transmissive encapsulation that substantially encloses the sensor and communications module, wherein the acoustically transmissive encapsulation is of ingestible size. The multi-sensor array includes a plurality of acoustic transducers that receive an acoustic signal from a movable device, and a plurality of delays, wherein each delay is coupled to a corresponding acoustic transducer.

Abstract: The present invention provides a micro-robot for use inside the body during minimally-invasive surgery. The micro-robot includes an imaging devices, a manipulator, and in some embodiments a sensor.

Abstract: The invention relates to a method and an arrangement for influencing magnetic particles in a region of action. Methods and arrangements of this kind can be used to determine the spatial distribution of magnetic particles in the region of action or to heat up the magnetic particles locally. If, in addition to the magnetic particles, there is also interfering material in the region of action then this material may heat up in an unwanted way. To avoid unwanted heating-up of this kind, any interfering material that may be present is detected beforehand. If there is interfering material present, then an examination or investigation, or treatment, can be carried out with changed system parameters.

Abstract: An apparatus and methods for treating sleep apnea and/or snoring are provided. The apparatus includes an appliance sized and structured to be placed in the pharyngeal region of a human or animal. The appliance, when so placed is effective in treating sleep apnea and/or snoring, for example in maintaining openness of an oropharyngeal region of a human or animal during natural sleep. Preferably, the appliance is non-circumferential in form and includes rounded, spaced apart end portions.

Abstract: A system for monitoring temperature in a body, the system comprising at least one implantable device, wherein the implantable device(s) is operable to sense temperature in the body and to generate status signals based on the sensed temperature in the body. The system further comprising a system control unit for wirelessly communicating with the implantable device(s), and the system control unit comprising a signal receiver for receiving the status signals, and also a programmable controller for producing notification signals based on the received status signals. A notification unit can alternatively communicate with the system control unit or the implantable device(s) for disclosing the sensed body temperature based on the notification signals.

Abstract: An electrophysiology catheter includes a tube having a proximal end, a distal end, and a lumen therebetween. The tube is preferably comprised of multiple sections of different flexibility, arranged so that the flexibility of the catheter increases from the proximal end to the distal end. There is a first generally hollow electrode member at the distal end. At least one magnetically responsive element is disposed at least partially in the hollow electrode, for orienting the distal end of the catheter with an externally applied magnetic field. Multiple magnets can be distributed over the distal portion of the device. The end electrode can have openings for delivering irrigating fluid, and/or a sleeve can be provided around the tube to create an annular space for the delivering of irrigating fluid. A temperature sensor can be provided to control the operation of the catheter. A localization coil can also be included to sense the position and orientation of the catheter.

Abstract: The invention provides tissue markings (such as tattoos) comprising magnetic particles, e.g., magnetite, and methods for making and altering, e.g., removing them.

Abstract: A method of navigating a medical device having a changeable magnetic moment within an operating region within a patient, the method includes applying a navigating magnetic field to the operating region with an external source magnet, and changing the direction of the magnetic moment in the medical device to change the orientation of the medical device in a selected direction within the operating region. The magnet moment of the medical device can be created by one or more electromagnet coils, in which case the magnetic moment can be changed by changing the current to the coil. Alternatively, the magnetic moment of the medical device can be created by one or more permanent magnets, in which case the magnetic moment can be changed by mechanically or magnetically manipulating the permanent magnet.

Abstract: The present invention is a miniature camera robot which can be placed entirely within an open space such as an abdominal cavity. The instant camera robot has pan and tilt capabilities, an adjustable focus camera, and a support component for supporting the robot body. In particular embodiments, the camera robot further contains a light source for illumination and a handle to position the camera robot. A system and method for using the instant camera robot are also provided.

Abstract: The invention is directed toward a magnetic valve reader used as an indicator tool. The magnetic valve reader determines a location and an orientation for a magnetic indicator device to indicate a device setting of an implantable medical device. The implantable medical device includes the magnetic indicator device coupled to a valve on the implantable medical device. External magnetic fields, specifically the Earth's magnetic field, may interfere with the compass and create an incorrect device setting indication. The electronic reader estimates the external magnetic fields to subtract the estimate from received data to minimize any influence that external magnetic field has on the accuracy of the device setting measurement.

Abstract: An oscillating shaft is scanned to provide images including the oscillating shaft in vivo in real-time with a real-time three-dimensional (3D) ultrasound scanner. An interventional device can be guided in vivo using an ultrasound scanner and includes a sheath having a bore therethrough from a proximal portion to a spaced-apart distal portion. A shaft has a proximal portion and a spaced-apart distal portion and is configured for insertion into the bore of the sheath. A vibrator is coupled to the proximal portion of the shaft and is configured to cause the distal portion of the shaft to oscillate at a shaft frequency. An isolator is coupled to the proximal portion of the sheath and to the vibrator, wherein the isolator is configured to reduce damping of an oscillation of the shaft by the sheath.

Abstract: This invention is an improved tissue localizing device for fixedly yet removably marking a volume of tissue containing a suspect region for excision. This invention also encompasses methods for deployment of the localizing device and its excision along with the marked tissue volume. At least one locator element is deployed into tissue and assumes a predetermined curvilinear shape to define a tissue border containing a suspect tissue region along a path. The locator element path preferably encompasses the distalmost portion of the tissue volume without penetrating that volume. Multiple locator elements may be deployed to further define the tissue volume along additional paths defining the tissue volume border that do not penetrate the volume. Other localization wire embodiments of the invention are disclosed in which the tissue volume may be penetrated by a portion of the device.

Abstract: A system for controlling the location of a therapeutic agent administered to a mammal is provided. The system employs a device that is capable of generating a magnetic field and a therapeutic agent labeled with a magnetically responsive moiety. Methods which employ the device and the therapeutic agent are also provided.

Abstract: A catheter for diagnosis or treatment of a vessel or organ is provided in which a flexible elongated body includes a tri-axial force sensor formed of a housing and a plurality of optical fibers associated with the housing that measure changes in the intensity of light reflected from the lateral surfaces of the housing resulting from deformation caused by forces applied to a distal extremity of the housing. A controller receives an output of the optical fibers and computes a multi-dimensional force vector corresponding to the contact force.

Abstract: An improved medical imaging device assembly includes an imaging transducer coupled to the distal end of a drive shaft, and a conductive wire is wrapped around a distal portion of the drive shaft, wherein the conductive wire reinforces the imaging device assembly. In one embodiment, the conductive wire is part of a sensor adapted to communicate with a medical positioning system. In another embodiment, the conductive wire is configured to be a matching circuit for the imaging transducer. The conductive wire may be configured to be in parallel with the imaging transducer or configured to be in series with the imaging transducer.

Abstract: A device for mobilizing, rotating and maneuvering an in vivo vehicle introduced into a subject by extracorporeal devices which control the position and motion of such a vehicle by detection and modulation of the strength and direction of the electromagnetic field vector of the vehicle. This invention employs a series of pulses, with specific characteristics over time, to induce magnetic field changes. The changes that result from the vehicle movement are measured and used to calculate the location and movement of the vehicle. A system and method for controlling the movement of the vehicle are also provided.

Abstract: A system for magnetically navigating a medical device in an operating region within the body of a patient. The system includes a magnet having a front field projecting from the front of the magnet sufficient to project a magnetic field into the operating region in the patient. The magnet is mounted for movement between a navigation position in which the magnet is located adjacent to the patient with the front of the magnetic generally facing the operating region, and an imaging position in which the magnet is spaced from the patient and the front generally faces away from the operating region.

Abstract: The invention relates to an instrument able to be introduced into a body as well as an imaging position fixing system and position fixing method for the instrument. A magnet able to be rotated with a rotation drive is provided in an end section of the instrument. The position of the magnet in the body can be determined on the basis of the strength of a magnetic alternating field created by a rotation of the magnet.

Abstract: Electrical cardiac therapy devices including electrode lead assemblies having first and second insertion tool receivers. The insertion tool receivers may be attached to an electrode and/or an electrode cover assembly. A lead assembly having first and second insertion tool receivers may be used in conjunction with an insertion tool having means, such as tines, for coupling with the insertion tool receivers. A lead assembly system may include both an insertion tool and a lead assembly. A treatment system further includes an implantable housing along with the lead assembly and insertion tool.

Abstract: A cardiac event microrecorder comprising a hermetically sealed housing is shaped and dimensioned to facilitate the subcutaneous implantation of the microrecorder in a human patient by injection through the lumen of a hypodermic needle. The housing comprises a tubular central section of an electrically insulating material, the central section having spaced apart extremities. An electrically conductive sense electrode is secured to and seals each extremity. The housing may have an interior enclosing (1) electrical circuitry for processing, storing and telemetering data representing physiologic information detected by the sense electrodes; (2) a primary cell or rechargeable battery for electrically powering the electrical circuitry; and (3) an inductively couplable charger where a rechargeable battery is used.

Abstract: A leadless marker for localizing the position of a target within a patient. In one embodiment, the marker includes a casing, a resonating circuit, and a ferromagnetic element. The casing is configured to be positioned at a selected location relative to a target site in the patient; the casing, for example, can be configured to be permanently or semi-permanently implanted into the patient. The resonating circuit has an inductor within the casing comprising a plurality of windings of a conductor, but it does not have external electrical lead lines extending through the casing. The ferromagnetic element is at least partially within the inductor. The ferromagnetic element has a volume such that when the marker is in an imaging magnetic field having a field strength of 1.5 T and a gradient of 3 T/m, then the force exerted on the marker by the imaging magnetic field is not greater than gravitational force exerted on the marker.

Abstract: A wireless communication system is provided that includes an antenna structure adapted for coupling to a medical device antenna when the medical device is not implanted in a patient's body. The antenna structure effectively extends the medical device antenna length, thereby improving the efficiency and reliability of a communication link between the medical device and a programmer or monitor outside the implanted environment. The antenna structure is fabricated from any conductive material, which may be in the form of conductive wire, tape, ink, foil, film, adhesive or the like, and is attached to a portion of a medical device packaging assembly or another accessory device or substrate such as a pouch or overlay. The antenna structure may be a monopole, dipole, slot antenna, microstrip patch, or loop antenna, and may be fixed or movable relative to the substrate on which it is implemented.

Abstract: A medical monitor is disclosed for implantation in a human body for monitoring biological activity and states as detected by implanted sensors. The medical monitor includes a primary disk drive and a secondary disk drive, where the secondary disk drive mirrors the primary disk drive. An enclosure surrounds at least one of the primary and secondary drives. A transmitter and receiver for produces and transmits signals. The medical monitor is in communication with the sensors, by which information on biological activity and states is stored on the primary disk drive, and the secondary disk drive.

Abstract: The present invention provides systems and methods for determining the coordinates of a location element mounted on a medical probe. First and second signals are transmitted between the location element and a first and second reference transducers, which may be arranged in a reference array that can be attached to a patient's skin. A transit time difference between the first and second signals is determined, e.g., using a thresholding or correlation technique. A distance difference between a first distance extending from the location element to the first reference element and a second distance extending from the location element to the second reference element is then determined based on the transit time difference. An angle between the reference array and the location element can then be determined based on the determined distance difference and a known distance between the first and second reference transducers.

Abstract: Light from a small laser diode is inserted in a distal end of a catheter and passed through an optical fiber that is either included in the lumen or incorporated into the wall of an invasive catheter tube during manufacture. The light is selected to be of a wavelength that is minimally absorbed by tissue, preferably in the range from about 620 nm to 1100 nm. 780 nm is preferably used as this is where the tissue absorption is near a minimum. The light passes out the end of the fiber (at the proximal end of the catheter) and through the tissue to the outside of the patient's skin where it is measured. The light pattern is observed by night vision goggles that filter out other frequencies of light. The detected light permits location of the end of the fiber, the positional accuracy depending on the thickness of tissue between the fiber tip and the exterior of the body. The method is highly accurate for small children and for catheters within a few centimeters of the skin surface of adults.

Abstract: A mapping and ablation catheter is described. In one embodiment, the catheter includes a MOSFET sensor array that provides better fidelity of the signal measurements as well as data collection and reduces the error generated by spatial distribution of the isotropic and anisotropic wavefronts. In one embodiment, the system maps the change in potential in the vicinity of an activation wavefront. In one embodiment, the mapping system tracks the spread of excitation in the heart, with properties such as propagation velocity changes. In one embodiment, during measurement, the manifold carrying the sensor array expands from a closed position state to a deployable open state. Spatial variation of the electrical potential is captured by the system's ability to occupy the same three-dimensional coordinate set for repeated measurements of the desired site. In one embodiment, an interpolation algorithm tracks the electrogram data points to produce a map relative to the electrocardiogram data.

Abstract: A catheter is provided that has a basket-shaped electrode assembly with an improved mechanism for expanding and contracting the electrode array. The expansion mechanism is designed to permit reproducible reintroduction of the catheter into the heart. The catheter comprises an elongated catheter body having at least one lumen therethrough. A basket-shaped electrode assembly is mounted at the distal end of the catheter body. The basket assembly comprises a plurality of spines connected at their proximal and distal ends, each of which comprises at least one electrode. The basket assembly has an expanded arrangement wherein the spines bow radially outwardly and a collapsed arrangement wherein the spines are arranged generally along the axis of the catheter body. An expander is attached at or near its distal end to the distal ends of the spines and extends through the catheter body. The expander has a proximal end that extends out the proximal end of the catheter body a lumen extending therethrough.

Abstract: The present invention discloses a method for the occlusion of blood vessels or fluid vessels to stop the flow of blood or fluid during elective or emergency surgical procedures or following traumatic injury. This invention also encompasses a medical device or tool for occluding, reducing, or controlling blood flow or fluid flow. In this invention, a plug or blockade is formed to occlude, reduce, or control blood flow or fluid flow when magnetic microparticles, nanoparticles, or colloids are administered into a blood vessel or fluid vessel, and an external magnetic field source is placed at the desired site near or above the path of the blood stream or fluid flow. Removal of said external magnetic field source would result in the redispersion of the microparticle blockade and resumption of the flow.

Abstract: A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing material and a resealable insertion site coupled to one end of the site housing material. Preferably, the site housing material is formed to have an interior cavity with an opening. The site housing material is selected to promote tissue ingrowth and vascularization, and yet be free of tissue ingress. Also, the site housing material permits the analyte to pass through the site housing material to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site provides a for inserting the replaceable analyte sensor into the interior cavity of the site housing material.

Abstract: A method of navigating the distal end of a medical device through an operating region in a subject's body includes displaying an x-ray image of the operating region, including the distal end of the medical device; determining the location of the distal end of the medical device in a reference frame translatable to the displayed x-ray image; and displaying an enhanced indication of the distal end of the medical device on the x-ray image to facilitate the navigation of the distal end of the device in the operating region.

Abstract: A method of applying an electrode on the end of a flexible medical device to the surface of a body structure, the method including navigating the distal end of the device to the surface by orienting the distal end and advancing the device until the tip of the device contacts the surface and the portion of the device proximal to the end prolapses. Alternatively the pressure can be monitored with a pressure sensor, and used as an input in a feed back control to maintain contact pressure within a pre-determined range.

Abstract: Electrical cardiac therapy devices including lead electrode assemblies for implantation into a patient comprising an electrode having a first face and a second face, and an appendage extending opposite the second face of the electrode, the appendage including an eyelet for securing an insertion device thereto. The assembly may further include an electrode frame assembly to which the appendage may be attached. Alternatively, the appendage may be formed as part of a molded electrode frame assembly. A backing piece may be provided between the electrode frame assembly and the electrode. The frame assembly may cover a portion of a front side of the electrode. Further embodiments include an electrode lead assembly including an appendage with an eyelet and an electrode insertion tool adapted to engage the eyelet.

Abstract: An improved catheter is provided that is particularly useful for mapping the Purkinje fibers for potential diagnosis of ventricular fibrillation. The catheter comprises an elongated catheter body having proximal and distal ends and at least one lumen extending longitudinally therethrough. Mounted at the distal end of the catheter body is a mapping assembly having at least two spines, each having a proximal end attached at the distal end of the catheter body and a free distal end. Each spine comprises at least one electrode, preferably a tip electrode and at least one ring electrode. An irrigation tube extends through the catheter body and has an open distal end that is in communication with the outside of the distal end of the catheter body. The spines may be arranged in an expanded arrangement wherein each spine extends radially outwardly from the catheter body or in a collapsed arrangement wherein each spine is disposed generally along the longitudinal axis of the catheter body.

Abstract: Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate said release or exposure of the reservoir contents. In another embodiment, the system comprises (1) a microchip device comprising a substrate a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a telemetry system for the wireless transfer of data between the microchip device and a remote controller.

Abstract: The invention relates to a folder module for folding a flexible intraocular implant for injection into the eye of a patient. The module comprises two jaws that are movable relative to each other, each jaw having a folder wall constituted by a portion of a cylindrical surface, and a plane wall secured to the folder wall, the two plane walls lying in parallel planes; a pivot axis orthogonal to the plane walls to control relative pivoting movement of one jaw relative to the other; one of the jaws being capable of occupying relative to the other a first position in which said plane walls are offset relative to each other; a second position in which the plane walls face each other so as to define an implant confinement volume; and a third position in which the folder walls meet each other to define a folder chamber enabling the implant to be finally folded.

Abstract: A lead is connected to an integrated circuit in an implantable medical device in a lead bonding region that includes a lead-receiving recessed region. At least a portion of a lead conductor is bonded in the lead-receiving recessed region, making an electrical and mechanical connection to the integrated circuit that is strong and potentially biostable. In some embodiments, a filler material is provided around the recessed portion of the integrated circuit that receives the lead conductor, and a metal coating is provided around an outer surface of the filler material for additional mechanical stability.

Abstract: A medical monitor is disclosed for implantation in a human body for monitoring biological activity and states as detected by implanted sensors. The medical monitor includes at least one hard disk drive. A transmitter and receiver for produces and transmits signals. The medical monitor is in communication with the sensors, by which information on biological activity and states is stored on the at least one disk drive. An enclosure surrounds the at least one hard disk drive, where the enclosure includes sound-proofing materials.

Abstract: The present invention provides a robot for use inside an open abdominal cavity during minimally-invasive surgery. The robot may include various sensors, imaging devices or manipulators.

Abstract: A self powered monitoring device for monitoring an animal's temperature and other vital signs. The device may be mounted in the animal's ear, under the animals skin, or in any location which can be used to generate a reliable indication of the animals temperature and other vital signs. The temperature probe for the device is inserted subcutaneously and thermally and/or electrically connected to the housing of the device. Power for the device is provided by a miniature array of solar cells, the power from the solar cells being used to drive digital circuitry which processes signals from the various probes used to gather data concerning the animal's vital signs. The size of the array is chosen to be commensurate with the number of vital signs monitored, with the amount of sunlight, density of herd, and other factors being considered to ensure sufficient power for the device.

Abstract: A magnetically navigable device has a magnet element with a greater extent in one direction than at right angles thereto. The magnet element is arranged asymmetrically with respect to a central axis of the device which points in the direction in which the magnet element extends. The device may be, for example, a video capsule from medical technology, such as for endoscopy.

Abstract: A lead stimulation/recording system is provided, which is a combination of a permanent DBS stimulating lead and a recording microelectrode. The DBS lead has a lumen extending from the proximal to the distal end of the lead, the lumen having an opening on each end of the lead. The microelectrode is configured and dimensioned to be insertable into the DBS lead from either the distal or proximal opening of the DBS lead, thereby permitting the microelectrode to be placed before, concurrently with, or after placement of the DBS lead. In addition, the system may be used with known microelectrode recording systems and methods of inserting the electrodes, such as the five-at-a-time method, the dual-microdrive method, or the single microdrive method.

Abstract: A magnetic anchor remote guidance system includes an engagement member which engages with a body portion in a patient's body; a magnetic anchor made of a magnetic material, connected to the engagement member; and a magnetic anchor guide device which is disposed out of the patient's body and which produces a magnetic field to power the magnetic anchor. The body portion engaged by the engagement member is raised by supplying power to the magnetic anchor via the magnetic field produced by the magnetic anchor guide device.

Abstract: A device for interacting with biota either on a pre-specified schedule or via actuation by remote signal. Preferably, the biota are fauna and more particularly fish. In selected embodiments, it comprises frangible packaging enclosing means for timing interaction, at least part of the means for programming the device and means for opening the packaging. In select embodiments of the present invention, the apparatus is inserted in fish. Specific examples of the present invention are implanted in triploid grass carp (Ctenopharyngodon idella) to facilitate control of aquatic weeds in bodies of water. When the carp have been in the water for a pre-specified period or, alternatively, long enough to effectively control the target aquatic plants, toxins in the device are dispensed to kill them. Otherwise, the carp may destroy all vegetation and harm the aquatic environment for other aquatic life.

Abstract: An apparatus for determining the position of a wireless catheter probe being used during a surgical procedure. Magnetic fields are projected into an anatomical body to induce voltage signals in a sensing coil that are sufficient to describe the position of a wireless sensor/transmitter. The voltage signals are wirelessly re-transmitted by the sensor/transmitter as positional signals indicative of a current location of the sensor/transmitter in the anatomical body. In a preferred embodiment, the wireless catheter probe is self-powered using the induced voltage signals on a sensing coil. In another embodiment, induced voltage signals of a separate coil are used to power the device.

Abstract: A graft grasping device includes a graft grasping member including a soft tubular grasping portion having a substantially C-shaped cross section and a suction tube which communicates with a lumen of the grasping portion and is connected to a side wall of the grasping portion. A recessed portion including at least a communication port which communicates with a lumen of the suction tube and the lumen of the grasping portion is formed on an inner wall of the grasping portion. The recessed portion is covered with a porous sheet and a mesh sheet is interposed between the recessed portion and the porous sheet.

Abstract: An improved basket catheter is provided that is particularly useful for mapping the heart. The catheter comprises an elongated catheter body having proximal and distal ends and at least one lumen therethrough. A basket-shaped electrode assembly is mounted at the distal end of the catheter body. The basket assembly has proximal and distal ends and comprises a plurality of spines connected at their proximal and distal ends. Each spine comprises at least one electrode. The basket assembly has an expanded arrangement wherein the spines bow radially outwardly and a collapsed arrangement wherein the spines are arranged generally along the axis of the catheter body. The catheter further comprises a distal location sensor mounted at or near the distal end of the basket-shaped electrode assembly and a proximal location sensor mounted at or near the proximal end of the basket-shaped electrode assembly.

Abstract: A surgical tool for safely introducing a gastric band into a patient's abdomen is provided. The instrument includes an inner rod slidably and coaxially disposed within a support tube. The inner rod includes a gastric band releasably secured thereon. Distal movement of the inner rod into the support tube exposes said gastric band.

Abstract: The present invention provides a micro-robot for use inside the body during minimally-invasive surgery. The micro-robot includes an imaging devices, a manipulator, and in some embodiments a sensor.

Abstract: The A fertilization process comprises includes the following steps: a) a container (15) which can be introduced into, and lodged in, the uterine cavity of the mammal is provided; b) the container (15) is filled with a culture medium, at least one ovocyte of the mammal, and spermatozoa; c) the filled container (15) is inserted into the uterine cavity; d) the container (15) is left for a given length of time to allow fertilization of the ovocyte(s) to take place; e) the contents of the container (15) are released into the uterine cavity. The container may be made from a tube of biodegradable or non-biodegradable material. In the latter case, it is associated with a stiffening device. A biodegradable container (15) filled with gametes and a culture medium is placed in the uterine cavity using an implantation device (20) which is then withdrawn from the mammal's genital tract.