Abstract: A method for treating cardiac arrest includes defibrillating the patient and/or ventilating the patient and/or administering a cardiac arrest drug such as epinephrine to resuscitate the patient, and then cooling the patient using one or more cooling catheter positioned in the central venous system of the patient.

Abstract: Apparati and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparati include microchip devices which have reservoirs containing the molecules for release. The apparati and methods provide for active or passive controlled release of the molecules. Preferred embodiments include systems for intravenous administration of drugs, wherein drug molecules are released from the microchip devices into a carrier fluid ex vivo, such as a saline solution, forming a drug/saline solution mixture which is then delivered to a patient intravenously.

Abstract: A system for and method of determining and compensating for the effect of a field influencing object on a field sensor, preferably a coil, that is within a navigational domain. The navigational domain contains navigational magnetic energy and disturbing magnetic energy, and the field influencing object produces the disturbing magnetic energy in response to the navigational magnetic energy. The correction system includes a first transmitter for projecting into the navigational domain field energy in a first waveform sufficient to induce a first signal value in the sensing coil. The system also includes a second transmitter for projecting into the navigational domain field energy in a second waveform sufficient to induce a second signal value in the sensing coil. The system further includes a signal processor for receiving the first signal value and for receiving the second signal value to determine the effect of the electrically conductive object on the field senior.

Abstract: The present invention provides a detectable heavy duty needle cannula (12) for use in hypodermic syringes and the like. Needle cannula (12) comprises a magnetizable or magnetized stainless steel alloy, which enables needle cannula (12) to be detectable in metal detectors that are commonly used in the meat processing industry to detect broken needle cannulas in the flesh of slaughtered animals. Needle cannula (12) further comprises a sidewall (17) that is thicker than the sidewalls of prior art needle cannulas. The thicker sidewall imparts to needle cannula (12) greater resistance to breakage during the process of injecting animal health products into an animal and greater detectability in a metal detector.

Abstract: A magnetic body scanning method and apparatus for scanning the entire body for a magnetic signature of a cluster of ferromagnetic nanoparticles in relation to the diamagnetic signature of the body.

Abstract: A microcoil configuration, preferably on a medical device to be inserted into a patient, has an opposed pair of microcoils. At least one or each microcoil of the opposed pair of microcoils has at least a region where a diameter circumscribed by a first winding is greater than the diameter circumscribed by at least one complete second winding, especially an adjacent winding displaced from the first winding along an axis or core of the medical device or an axis of the microcoil. The second winding is nearer to or farther from an intermediate region between the microcoils that define the pair of microcoils. For example, it is common to have a connecting (usually straight or non-wound) lead between the two microcoils, and this lead may be used to define an intermediate region.

Abstract: A system and method for localizing an in vivo signal source using a wearable antenna array having at least two antenna elements. The signal is received and a signal strength is measured at two or more antenna elements. An estimated coordinate set is derived from the signal strength measurements.

Abstract: The SENSE ORGANS SYNTHESIZER, for BLIND, DEAF, and BALANCE ORGANS IMPAIRED, synthesizes three types of sense organs (EYES, EARS, or BALANCE ORGANS). The senses are ‘perceived’, as if synthetic organs are real. My invention does NOT perform this; it is a feat of the SUBCONSCIOUSNESS. What is new about my invention is simple; I presume upon the following AUTONOMIC FUNCTIONS of subconsciousness: 1) (It) MUST analyze any and all organized/patterned subliminal signals for the meanings, 2) then it presents the meanings (not the original signals) to the consciousness. 3) The subconscious “has no choice” in these matters, is totally unprejudiced, and cannot even refuse these functions. A camera, microphone, or balance sensors, are input to a programmed microprocessor, that digitizes video, audio, or balance signals, such that they can be comprehended by the subconscious. Delivery is through linear arrayed electrodes' signals, to a few hundred TOUCH NERVE ZONES.

Abstract: An apparatus for determining the position of a wireless catheter probe being used during a surgical procedure. Magnetic fields are projected into an anatomical body to induce voltage signals in a sensing coil that are sufficient to describe the position of a wireless sensor/transmitter. The voltage signals are wirelessly re-transmitted by the sensor/transmitter as positional signals indicative of a current location of the sensor/transmitter in the anatomical body. In a preferred embodiment, the wireless catheter probe is self-powered using the induced voltage signals on a sensing coil. In another embodiment, induced voltage signals of a separate coil are used to power the device.

Abstract: The bolus is intended to be received in the reticulum of a ruminant. It comprises a body (10) having a housing (12) for containing a data interchange device (14). According to the invention, the body (10) is made of a material based on alumina, Al2O3, and/or on silica, SiO2.

Abstract: A heartburn and reflux disease treatment apparatus includes an adjustable restriction device implanted in a patient and engaging the stomach close to the cardia or engaging the esophagus to form a restricted cross-sectional area of the food passageway in the stomach or esophagus, and a post-operation non-invasive adjustment device for mechanically adjusting the restriction device to change the cross-sectional area of the passageway. By using a wireless remote control the patient can control the adjustment device, whereby the restriction device works like an artificial sphincter.

Abstract: Devices and methods which sense a biopotential are disclosed. The sensed biopotential is used to modulate an output signal. The power of the output signal is limited so that the signal will attenuate within a predetermined distance. In one embodiment, a wireless ECG electrode has a transmitter in communication with the electrode. The transmitter outputs a signal which is modulated by the output of the electrode. The power of the signal is limited so that the signal will attenuate within a predetermined distance from a transmission point.

Abstract: A method of navigating a medical device having a changeable magnetic moment within an operating region within a patient, the method includes applying a navigating magnetic field to the operating region with an external source magnet, and changing the direction of the magnetic moment in the medical device to change the orientation of the medical device in a selected direction within the operating region. The magnet moment of the medical device can be created by one or more electromagnet coils, in which case the magnetic moment can be changed by changing the current to the coil. Alternatively, the magnetic moment of the medical device can be created by one or more permanent magnets, in which case the magnetic moment can be changed by mechanically or magnetically manipulating the permanent magnet.

Abstract: A heartburn and reflux disease treatment apparatus and method include and utilize: an operable restriction device implanted in a patient and engaging the stomach close to the cardia or engaging the esophagus to form a restricted passageway in the stomach or esophagus, a source of energy for energizing the restriction device, and a control device for releasing energy from the source of energy from outside the patient's body. The released energy is used in connection with the operation of the restriction device including to enlarge or contract the restricted passageway.

Abstract: A system that remotely measures displacement between two objects. A passive sensor is affixed between the objects. The internal sensor uses magnetic coupling between two sensor elements to measure their relative displacement. The sensors are either a) a permeable rod and a complimentary coil in parallel with a tuning capacitor; or b) two permeable rods, each having its own surrounding coil and a tuning capacitor. One of the sensor elements is affixed to each object which is to be monitored. When an interrogating device is placed near the sensors, a resonance can be measured whose frequency characteristics change in a reproducible manner with the relative displacement of the sensors. The resulting resonance characteristics can be calibrated in such a way as to enable the displacement of the objects to be determined.

Abstract: A food intake restriction apparatus and method includes and uses an operable restriction device implanted in a patient and engaging the stomach or esophagus to form a restricted stoma opening in the stomach or esophagus. A source of energy for energizing the restriction device, and a control device for releasing energy from the source of energy from outside the patient's body are provided. The released energy is used in connection with the operation of the restriction device to vary the size of the stoma opening to allow or substantially prevent the passage of food therethrough.

Abstract: An articulated magnet assembly optionally includes one or two additional fixed magnets to guide or move such as by pulling or pushing a magnetic structure in the body. The magnetic structure may be a magnetic tip of a catheter or a magnetic seed, or other such magnetic assembly, implant or device. The device is arranged to facilitate biplanar, real-time, X-ray imaging of the patient. The moved magnet can be a large, strong permanent magnet or a cored solenoid. The added, fixed electromagnets may have either normally conducting or superconducting coils. The magnet on the articulated magnet assembly can move radially, along a polar direction, and at an azimuthal angle, and may also pivot in place to direct an opposite pole of the magnet in the direction of the patient.

Abstract: A food intake restriction apparatus and method for an obese patient includes and uses an energy transmission device for wireless transmission of energy of a first form from outside the patient's body. An operable restriction device is implanted in the patient and engages the stomach or the esophagus to form an upper small pouch of the stomach, and a restricted stoma opening is formed in the stomach or esophagus. The restriction device is operable in response to a second energy form different than the first form to vary the restricted stoma. An energy transfer device is implanted in the patient for transferring energy of the first form transmitted by the energy transmission device into energy of the second form.

Abstract: A field transducer (30) for determining position or orientation in a medical instrument locating system is placed at an arbitrary position or orientation with respect to a feature (62) of the instrument (46). The transducer (30) may be attached at a arbitrary location on the instrument (46), or the instrument (400, 404) may be bent as desired by the user. A transform relating position or orientation of feature of the instrument to position or orientation of the tranducer is obtained in a caliration cycle. A field transducer may be part of a disposable unit which is irrevocably altered when used with an instrument so that the unit cannot be reused.

Abstract: Methods and apparatus for communication of implantable medical device (IMD) information, including interrogation of programmed parameter values, operating modes and conditions of operation, confirmation of programmed changes thereof, interrogation of data stored in the IMD, and patient warnings or other messages by RF transmission of audible sounds generated by the IMD are disclosed. The IMD includes an RF transmitter that broadcasts or transmits audible sounds including voiced statements or musical tones stored in analog memory correlated to a programming or interrogation operating algorithm or to a warning trigger event. The broadcast radio signal is received, and the audible sounds are demodulated and reproduced by a radio receiver as voiced statements or musical tones that convey human understandable messages comprising IMD information generated during programming and interrogation sessions and warnings or status messages to the patient at other times.

Abstract: A heartburn and reflux disease treatment apparatus and method includes and uses an operable restriction device implanted in a patient and engaging the stomach close to the cardia or engaging the esophagus to form a restricted passageway in the stomach or esophagus. A source of energy external to the patient's body and a control device for releasing wireless energy from the source of energy from outside the patient's body are provided, so that the released wireless energy is used in connection with the operation of the restriction device to enlarge or contract the passageway.

Abstract: Determining the locations of therapeutic seeds implanted in a body part by distinguishing the therapeutic seeds from the body part by imposing physical changes on the therapeutic seeds and sensing these physical changes in the therapeutic seeds. In one form of the invention, the therapeutic seeds are partially ferromagnetic and are caused to vibrate by a magnetic field and the vibrating therapeutic seeds are identified by reflections of ultrasonic signals transmitted to the therapeutic seeds.

Abstract: A substantially spherical semiconductor ball implanted in orthopedic structures for sensing and/or stimulation. In one embodiment, a vertebral column (800) having a number of intervertebral discs (802) interspersed among respective vertebral bodies (804), material placed in intervertebral discs (802) allows for a semi-synthetic vertebral disc (806) to be constructed. The artificial intervertebral disk (806) contains one or more ball sensors (808) located within the body of the disk (806) in order to monitor the compression forces. Conventionally, the semi-synthetic disc (806) is monitored only retrospectively, and visualized on x-ray.

Abstract: A system for testing for the existence of a biomedical condition of an animal test subject having first and second devices for projecting radiant energy. The first device for projecting radiant energy projects a beam of radiant energy into and through the tissue of a portion of the animal test subject. The second device for projecting radiant energy is implanted in the body of the animal test subject and projects a second beam of radiant energy out of the body in response to the projected radiation of the first radiant energy source. The second device for projecting radiant energy can be a mirror that reflects the first beam of radiant energy or it can be a source of radiant energy, such as a vertical-cavity surface-emitting laser, that emits a specific wavelength of light when activated by the first device for projecting radiant energy. A detector positioned outside the body and relative to the second device for projecting radiant energy detects the second beam of radiant energy.

Abstract: A sensing probe assembly and method for locating a magnetic field emitted by an implanted medical device. The assembly has a housing containing a magnetic field sensor circuit having an indicator light and a magnetic switch. The assembly further has a structure for marking the location of the magnetic field. The method utilizes a marking system whereby at least four points forming at least two perpendicularly intersecting line segments are located and marked above the magnetic field. The intersection is then used as a reference point for performing a medical procedure on the implanted medical device.

Abstract: An implantable biosensor system for monitoring and optionally alleviating a physiological condition in a patient is provided and includes (a) at least one sensor for sensing at least one parameter of a physiological condition and for generating electrical sensor signals representative of the physiological condition; and (b) a first acoustic activatable transducer being directly or indirectly coupled with the at least one sensor, the first acoustic activatable transducer being for converting a received acoustic interrogation signal from outside the patient's body into an electrical power for energizing the processor, the first acoustic activatable transducer further being for converting the electrical sensor signals of the at least one sensor into acoustic signals receivable out of the patient's body, such that information pertaining to the at least one parameter of the physiological condition can be relayed outside the patient's body upon generation of an acoustic interrogation signal.

Abstract: A system for monitoring, directing and controlling the dose of radiation in a medical procedure for irradiating a specific region of a patient's body. In its generic form, the system includes at least one sensor being implantable within, or in proximity to, the specific region of the patient's body, the at least one sensor being for sensing at least one parameter associated with the radiation. The system further includes a relaying device which is in communication with the sensor(s). The relaying device serves for relaying the information outside of the patient's body.

Abstract: A magnetically navigable atherectomy device includes a cutting head, a flexible drive shaft having a proximal and a distal end, with the cutting device on the distal end, and a magnet associated with the cutting head, the magnet of sufficient size to allow the cutting head to be oriented by an externally applied magnetic field. The magnet may be a portion of the cutting head made from a magnetically permeable or permanent magnetic material, a portion of the drive shaft made from a magnetically permeable or permanent magnetic material; a separate magnet between the cutting head and the drive shaft, a portion a magnet on a sheath covering the drive shaft. Alternatively a guide wire can provided with a magnetic material on its distal end. Through the application of a magnetic field and/or a magnetic gradient, the artherectomy device can be guided to the location of the atheromatous material in the body.

Abstract: A system for magnetically assisted surgery includes a magnetic support structure, a patient support structure and a magnet having at least four poles attached to the magnetic support structure so that the magnet provides a near-field magnetic field in an operating region of a patient supported by the patient support structure. The magnet is moveable so that the direction of the magnetic field lines in the operating region is adjustable. The magnet may include a pair of essentially semicircular half-segments permanently magnetized and joined in an extremely stable disk configuration. The magnetic field and gradient field provided by the magnet is such that movement of the disk in one plane combined with rotation of the disk is sufficient to orient the magnetic field during surgical use, thereby reducing interference to medical imaging devices needed during surgery.

Abstract: A method for localization of surgical target sites in the region of soft body parts, including the following steps: applying a number of artificial landmarks to the body part permitting sensing by a referencing system; referencing the surgical target site location relative to a landmark arrangement in a first position of the body part; sensing a new landmark arrangement in a changed second position of the soft body part; and mapping the dislocation or new location of the surgical target site by means of the information as to the dislocation or new arrangement of the landmarks.

Abstract: An implantable identification marker comprises an electronic device (4) enclosed within a vial (1; 2) isolating the device (4) from body fluids of the animal after insertion of the marker into the body of an animal. The marker further comprises a fixation structure (8; 5) providing a significantly in-creased total surface of the marker and/or a reduced specific weight of the marker. This improves the integration of the marker into the surrounding tissue avoiding migration within the animal.

Abstract: A guide for controlling the orientation of a medical device includes a cannula having a lumen therein for the medical device, and a guide member having a passage therein for receiving and directing the medical device, the guide member being movably mounted in the cannula for movement. The guide member can be magnetically responsive to an externally applied magnetic field, or can be magnetically responsive to an externally applied magnetic field when a magnetic medical device is in the passage, and/or it can be mechanically responsive.

Abstract: This invention is an improved tissue localizing device for fixedly yet removably marking a volume of tissue containing a suspect region for excision without penetrating that volume. This invention also encompasses methods for deployment of the localizing device and its excision along with the marked tissue volume. At least one locator element is deployed into tissue and assumes a predetermined curvilinear shape to define a tissue border containing a suspect tissue region along a path. The locator element path preferably encompasses the distalmost portion of the tissue volume without penetrating that volume. Multiple locator elements may be deployed to further define the tissue volume along additional paths defining the tissue volume border that do not penetrate the volume. Polar and tangential deployment configurations as well as a locator element that may be cold-formed by a die in the distal portion of the deployment tube into a permanent arcuate shape is also disclosed.

Abstract: An apparatus, system, method and computer program product for monitoring and controlling bio-enhancement implants is provided. With the apparatus, system, method and computer program product, a user may control the operation of implantable devices within the user's body by operation of a personal digital device. The personal digital device may obtain operational settings of the various implantable devices based on information stored within the personal digital device and/or information obtained from a network. The settings of the various implants are established in view of the possible interactions of the implants with one another. The personal digital device further monitors the operation of the implantable devices and the user's biological indicia. Based on the monitoring, the operation of the implantable devices are modified to obtain a desired result.

Abstract: A method of navigating a medical device having a changeable magnetic moment within an operating region within a patient, the method includes applying a navigating magnetic field to the operating region with an external source magnet, and changing the direction of the magnetic moment in the medical device to change the orientation of the medical device in a selected direction within the operating region. The magnet moment of the medical device can be created by one or more electromagnet coils, in which case the magnetic moment can be changed by changing the current to the coil. Alternatively, the magnetic moment of the medical device can be created by one or more permanent magnets, in which case the magnetic moment can be changed by mechanically or magnetically manipulating the permanent magnet.

Abstract: An apparatus and method are disclosed for accurately detecting the detachment of both electrically conductive and non-conductive implants which have been introduced to and are intended to remain at a desired therapeutic site. The detachment detection apparatus may include a conductive or an electrically-isolated implant, such as a vasoocclusive coil, connected to a wire by an electrolytically severable joint. The detachment assembly further includes a power supply having a direct current drive circuit for supplying a direct current to the joint, an alternating current drive circuit for independently supplying an alternating current to the joint, and an alternating current monitoring circuit for monitoring an alternating current level of the alternating current supplied to the joint. The detection assembly includes a central processing unit for selecting a first mode and a second mode for determining a detachment threshold level indicating detachment of the implant.

Abstract: This invention is an improved tissue localizing device for fixedly yet removably marking a volume of tissue containing a suspect region for excision. This invention also encompasses methods for deployment of the localizing device and its excision along with the marked tissue volume. At least one locator element is deployed into tissue and assumes a predetermined curvilinear shape to define a tissue border containing a suspect tissue region along a path. The locator element path preferably encompasses the distalmost portion of the tissue volume without penetrating that volume. Multiple locator elements may be deployed to further define the tissue volume along additional paths defining the tissue volume border that do not penetrate the volume. Other localization wire embodiments of the invention are disclosed in which the tissue volume may be penetrated by a portion of the device.

Abstract: A permanently implantable positioning and fixing system for positioning and fixing of an implantable device relative to a human body, including a plate member constructed to affix to the human body a ball-and-socket joint having a socket attached to the fixing member and a ball positionably mounted in the socket, a clamp mechanism cooperating with the ball-and-socket joint for selectively fixing the ball relative to the socket, a guide rail which is fixed to the ball of the ball-and-socket joint, the guide rail including outer guide surfaces, a threaded spindle having an outer thread, the threaded spindle being mounted to rotate relative to the guide rail and to prevent axial movement of the threaded spindle, a carriage with a feed nut having an inner thread that is engaged by the outer thread of the threaded spindle in a manner that the carriage is freely positionable along the guide rail by turning the threaded spindle, the carriage including inner guide surfaces that slidingly engage the outer guide surfac

Abstract: A vascular filter comprises an emboli-capturing portion having a set of helical filter-wires joined at a central region and extending in a given direction along the blood vessel in a diverging relationship to the axis of the filter, the wires terminating in free ends constructed to engage the walls of said vessel. A major mid-portion of the length of the free ended wires are of generally helical form, cooperatively related to form an effective emboli capturing array. Anchoring is accomplished by a separate assembly formed of struts and anchoring devices. A parallelogram supporting strut assembly and other means for providing linear engagement with the wall of the vena cava are shown. The parallelogram structure is shown to have filter capability by itself as well.

Abstract: Apparatus and methods for treatment of male incontinence and a method for female cystocele repair are disclosed in which a sling material is positioned between the descending rami of the pubic bone. In such an operation a “hammock-like” sling material is positioned below the urethra in males, or below the posterior bladder wall in the case of cystocele in females.

Abstract: A flexible instrument includes a flexible member having an intermediate portion and a distal tip. At least one intermediate sensor disposed at a predetermined point along the intermediate portion of the member provides an intermediate path signal indicative of the path of the intermediate portion of the flexible member. At least one distal sensor positioned proximate the distal tip of the flexible member provides a distal tip position signal indicative of the position of the distal tip of the flexible member.

Abstract: An improved system for monitoring the status of an IMD such as a medical electrical lead during an implant procedure is provided. The system includes a signal generator for supplying a first signal such as a constant current or voltage to the IMD. A resulting voltage or current signal is generated, respectively, and may be sensed as an indication of the impedance of a portion of the body that is proximal to one or more electrodes carried by the lead. This impedance indication is converted to an audible signal having a frequency that is proportional to the amplitude of the impedance indication. The pitch of the audible signal therefore rises when measured impedance increases, and drops as the impedance decreases. These pitch changes allow a user to determine positional information associated with the IMD, including the degree of lead tissue contact and extent of fixation of a device to tissue.

Abstract: A medical device incorporating magnetic material is introduced into the body of a patient. A time varying magnetic field is generated externally of the patient's body and which is of sufficient strength to magnetically induce motion in the device, thereby causing the medical device to vibrate within the patient's body. The frequency and the amplitude of the magnetic field oscillations can be continuously varied to control the vibrations induced in the medical device.

Abstract: A method of affixing a graft to bone using a the combination of a graft fixation device and an insertion member. The fixation device is useful for affixing a tissue graft to a bone or other body surface. The graft fixation device comprises two implantation members connected by a connecting member. The implantation members have longitudinal passageways therethrough. The insertion device member similarly has a longitudinal passage.

Abstract: A system and method for bracketing a tissue volume (22) and later locating the bracketed tissue volume. The system includes a plurality of markers (30) and a probe (32) and detector (34) for use in locating the markers by providing information usable by a surgeon that is representative of changes in proximity between the probe and the plurality of markers. The markers have various detection characteristics, e.g., they transmit gamma rays, that are detectable by an associated probe and detector. The tissue volume is removed by manipulating a cutting tool based on the proximity information provided by the detector which can be used by the surgeon to define the boundary of the tissue volume. A two-part cutting tool (200) is provided for removing the tissue volume, and a tissue anchor (300) is provided for stabilizing the tissue during removal. The system and method of the invention are particularly useful in bracketing and then removing a tissue volume from amorphous, pliable tissue such as breast tissue.

Abstract: Methods for delivering vibrational energy to subcutaneous tissue sites comprise externally generating acoustic energy and directing the external energy to an implanted structure which is capable of resonating at a pre-selected frequency. The vibration of the implanted structure, in turn, will reradiate heat and mechanical energy into tissue surrounding the structure. In one example, the implanted structure is a stent and the vibrational energy is intended to inhibit hyperplasia in a blood vessel in which the stent is implanted.

Abstract: The present invention provides devices, methods, and systems that monitor and track medical products, including surgical implements. The device can be a surgical implement including at least one integrated circuit that uniquely identifies the surgical implement by a unique identifier is provided. One method for monitoring and tracking surgical implements includes identifying at least one surgical implement including an integrated chip, where each surgical implement is uniquely identified. Systems for monitoring and tracking surgical implements are also provided. One system includes at least one surgical implement, each surgical implement including an integrated circuit that stores a unique identifier of the surgical instrument and a detector that detects the surgical implement by detecting the unique identifier from the integrated circuit. Labels for labeling medical products are also provided.

Abstract: An implantable device incorporating an acoustic transducer allows information and alerts to be communicated from the device to a patient. Sounds, including but not limited to buzzes, tones, sequences of tones, combinations of tones, complex sounds, and segments of reproduced or simulated human speech, are transmitted from an intracranially implanted portion of the device via bone conduction to the patient's ears, particularly the inner ears. In the disclosed embodiment, the acoustic transducer is used in cooperation with an implantable closed-loop system for the treatment of certain neurological disorders such as epilepsy, migraine headaches and Parkinson's disease, to warn the patient of an imminent seizure or other episode, to provide information to the patient on the state of the implantable apparatus, and to provide reminders and other information to the patient.

Abstract: These are subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.

Abstract: An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.