Disposable Apparatus Or Apparatus Having Removable Section (e.g., Removable Cartridge, Etc.) Patents (Class 204/403.02)
  • Publication number: 20130270113
    Abstract: An electrochemical strip is disclosed. The electrochemical strip includes a substrate and an electrode deposited on the substrate. The electrode includes a conductive paste layer, a first metal layer, a second metal layer, a third metal layer, and a fourth metal layer. The conductive paste is made of a material selected from the group consisting of copper paste, nickel paste, silver paste, and silver-carbon paste. The first metal layer is made of a group VIII metal. The second metal layer is made of nickel. The third metal layer is made of a group VIII metal. The fourth metal layer is made of a material selected from the group consisting of palladium, gold, and platinum.
    Type: Application
    Filed: April 11, 2012
    Publication date: October 17, 2013
    Inventor: Chuan-Hsing HUANG
  • Publication number: 20130256132
    Abstract: A test strip structure is provided, and more particularly to a blood glucose test strip, which facilitates permeating blood, comprises a plurality of conductive strips disposed over a top of a base layer, and a first insulation glue layer covering with the conductive strip. A roof plate layer is disposed over a top of the first insulation glue layer. One end of the conductive strip is capable of receiving a detection of a blood glucose machine while another end is disposed with a reaction layer. The first insulation glue layer is formed with a notch portion relative to the reaction layer. The notch portion is formed with a notch port, which is at one end of the base layer, capable of providing blood to permeate into the reaction layer. The first insulation glue layer has a ventilation gutter communicating with the notch portion.
    Type: Application
    Filed: March 30, 2012
    Publication date: October 3, 2013
    Inventor: Erik Chen
  • Patent number: 8540935
    Abstract: The present invention provides a test strip for measuring a concentration of an analyte of interest in a biological fluid, wherein the test strip may be encoded with information that can be read by a test meter into which the test strip is inserted. In one embodiment, a first test strip comprises: a first measurement electrode connectable to a test meter; a first trace loop with a first associated resistance, where the first trace loop is connectable to the test meter; and a second trace loop with a second associated resistance, where the second trace loop is connectable to the test meter. The test meter is adapted to: receive the first test strip; connect to the first measurement electrode, the first trace loop, and the second trace loop; and obtain a first resistance ratio by comparing the first and second associated resistances.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: September 24, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Terry A. Beaty, David W. Burke, Michael J. Celentano
  • Publication number: 20130228474
    Abstract: An analytical test strip (“ATT”) for use with a test meter includes a first insulating layer, with a first insulating layer upper surface, and a first electrically conductive layer (“ECL”) disposed thereon. The first ECL includes a first electrode portion (“EP”) and an electrical contact pad in electrical communication with the first EP. The ATT also includes a patterned spacer layer disposed above the first ECL that includes (i) a distal portion defining a bodily fluid sample-receiving chamber therein that overlies the first EP and (ii) an insulating proximal portion with an upper surface having a second ECL disposed thereon. The second ECL includes an interlayer contact portion and an electrical contact pad. A third ECL of the ATT includes a second EP and a proximal portion that overlies the interlayer contact portion. The second EP is disposed overlying and exposed to the sample-receiving chamber in an opposing relationship to the first EP.
    Type: Application
    Filed: March 2, 2012
    Publication date: September 5, 2013
    Inventors: Scott SLOSS, Russell BAIN, Graeme WEBSTER
  • Publication number: 20130228475
    Abstract: An analytical test strip with inert carrier substrate for use with a test meter includes an analytical test strip module and an electrochemically and electrically inert carrier substrate. The analytical test strip module has a first electrode portion, a second electrode portion in an opposing relationship to the first electrode portion, and first and second electrical contact pads configured in a stacked unidirectional configuration. The electrochemically and electrically inert carrier substrate has an upper surface and an outer edge. Moreover, the analytical test strip module is attached to the upper surface of the electrochemically and electrically inert carrier substrate such that the first and second electrical contact pads extend beyond the outer edge of the electrochemically and electrically inert carrier substrate and such that the electrochemically and electrically inert carrier substrate extends beyond the analytical test strip module.
    Type: Application
    Filed: August 14, 2012
    Publication date: September 5, 2013
    Inventors: Steven John Setford, Scott John Sloss, Lawrence Julian Ritchie
  • Patent number: 8518662
    Abstract: A disposable cassette for blood analysis includes a housing having an upper panel and a sampling section having a filling inlet; at least one pair of chambers in a form of depression of the upper panel of the housing and sealed by a diaphragm; portions of the diaphragm over the chambers being flexible; and one or more channels adapted to interconnect the pair of chambers; one of the chambers containing a predetermined amount of a reagent for blood analysis; and a sample outlet disposed next to and connected to the chamber containing the reagent, the sample outlet including an outlet cavity recessed from the upper panel, a divider disposed therein, and a cover covering the outlet cavity; the sample outlet sealing the reagent to the chamber containing the reagent. Further disclosed is the method of using the disposable cassette for measurements of hematology parameters on a blood analyzer.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: August 27, 2013
    Assignee: Boule Medical AB
    Inventors: Kalle Ritzen, Ingemar Berndtsson, Björn Roos, Gunnar Magnusson
  • Patent number: 8518342
    Abstract: The present invention relates generally to the field of analysis, for example biological analysis.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: August 27, 2013
    Assignee: Biomerieux
    Inventors: David Mosticone, Pascal Montes, Jean-Claude Raymond, Bruno Colin, Cecile Paris
  • Patent number: 8506908
    Abstract: An electrochemical detection system having a disposable cartridge capable of performing a plurality of assay protocols is disclosed. The cartridge includes a blister pack for the long-term storage and controlled release of multiple reagents. The blister pack is bonded to and operatively associated with a fluidic backbone for providing the fluid pathways, storage capacity, and fluid control functions for performing multiple assay protocols. The cartridge further includes a plurality of sensors having a multiple electrode arrangement in operative association with a respective flow cell defined by the fluidic backbone. After the user has transferred a sample into the cartridge and engaged the cartridge to the reader, the reader operatively interfaces with the cartridge such that different assay protocols may be simultaneously performed in isolation from one another inside the cartridge. The reader may be one of many readers that operatively communicate data to a remote server for processing.
    Type: Grant
    Filed: March 10, 2008
    Date of Patent: August 13, 2013
    Assignee: Vantix Holdings Limited
    Inventors: Jim Benn, Bruce Carvalho, Andy Gover, Roger Morris
  • Patent number: 8496794
    Abstract: A biosensor includes a working electrode 101, a counter electrode 102 opposing the working electrode 101, a working electrode terminal 103 and a working electrode reference terminal 10 connected to the working electrode 101 by wires, and a counter electrode terminal 104 connected to the counter electrode 102 by a wire. By employing a structure with at least three electrodes, it is possible to assay a target substance without being influenced by the line resistance on the working electrode side.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: July 30, 2013
    Assignee: Panasonic Corporation
    Inventors: Hiroya Ueno, Junji Nakatsuka
  • Publication number: 20130189794
    Abstract: This invention relates generally to devices and methods for performing optical and electrochemical assays and, more particularly, to test devices, e.g., cartridges, methods and systems, wherein the test devices have an entry port configured to receive a test sample into a holding chamber; a first conduit having at least one lateral flow test strip; and a displacement device, such as a pneumatic pump, configured to move a portion of said test sample from said holding chamber into said first conduit. The present invention is particularly useful for performing immunoassays and/or electrochemical assays at the point-of-care.
    Type: Application
    Filed: December 21, 2012
    Publication date: July 25, 2013
    Applicant: ABBOTT POINT OF CARE INC.
    Inventor: Abbott Point of Care Inc.
  • Publication number: 20130180869
    Abstract: An electrochemical test strip is provided, including a substrate, an electrode structure and an insulative film. The electrode structure is formed on the substrate, including a first electrode and a second electrode. The second electrode includes a first end, a second end, an extension portion, and a bent portion. The extension portion connects the first end with the bent portion, and the bent portion is connected to the second end. The extension portion and the first electrode define a space therebetween for receiving the bent portion. The insulative film covers at least a part of the electrode structure and forms an opening. A sample fluid enters the electrochemical test strip through the opening, and the sample fluid sequentially contacts the first electrode and the second electrode.
    Type: Application
    Filed: January 11, 2013
    Publication date: July 18, 2013
    Applicant: DELBIO, INC
    Inventor: DELBio, INC
  • Publication number: 20130175184
    Abstract: A test meter for receiving a test strip comprises: (a) a housing; (b) electronic circuitry disposed within the housing and (c) a strip port connector connected to the electronic circuitry and extending to an opening in the housing, said strip port connector connecting the electronic circuitry with a received test strip. The strip port connector contains a pair of top and bottom contacts, said top and bottom contacts having a proximal end and a distal end and a central contact portion, the top and bottom contacts of the pair are transversely aligned with one another; and the distal ends of the top and bottom contacts are separated or separable from one another by insertion of a test strip between the opposed contacts. The contacts and the meter are adapted to permit detection of faulty contacts and/or coding associated with an inserted test strip.
    Type: Application
    Filed: September 16, 2011
    Publication date: July 11, 2013
    Applicant: AGAMATRIX, INC.
    Inventors: Sridhar Iyengar, Charles Boiteau, Martin Forest, Colin Butters
  • Patent number: 8480867
    Abstract: Apparatus are disclosed for measuring substrate content present in a specimen that is applied to a biosensor, where the apparatus include an input for receiving an electrical signal from the biosensor; and a circuit coupled to the input to detect the electrical signal to determine whether an amount of the specimen needed for specimen detection has been supplied to the biosensor; where the apparatus measures the substrate content included in the specimen when the circuit determines that an amount of the specimen needed for specimen detection has been supplied to the biosensor, and the apparatus is prevented from measuring the substrate content included in the specimen when the circuit determines that the specimen has not been sufficiently supplied to the biosensor.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: July 9, 2013
    Assignee: Panasonic Corporation
    Inventors: Shoji Miyazaki, Masaki Fujiwara, Yoshinobu Tokuno
  • Patent number: 8480866
    Abstract: A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: July 9, 2013
    Assignee: Panasonic Corporation
    Inventors: Shoji Miyazaki, Eriko Yamanishi
  • Publication number: 20130168266
    Abstract: The present invention describes a biosensing device and method. Specifically, binding of target analyte to a sensor strip provides for reduction of metal ions in solution. The reduced metal can perform catalytic reactions leading to the production of easily identifiable products such as gas bubbles or colored molecules.
    Type: Application
    Filed: January 1, 2012
    Publication date: July 4, 2013
    Inventor: ALAN JOSEPH BAUER
  • Patent number: 8460523
    Abstract: The present invention relates to an analytical tool (X1) to be mounted to an analytical apparatus (1) which includes a plurality of terminals (11, 12) and an analysis circuit (13). The analytical tool includes a plurality of electrodes (21, 22) coming into contact with the plurality of terminals (11, 12) when mounted to the analytical apparatus (1). In the analytical tool (X1), at least one (12) of the electrodes (21, 22) serves as a disturbing-noise countermeasure electrode to which disturbing noise is more likely to come in comparison with the other electrodes (11) than the above-mentioned electrode (12).
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: June 11, 2013
    Assignee: Arkray, Inc.
    Inventors: Yasunori Shiraki, Yasuhide Kusaka, Taizo Kobayashi
  • Publication number: 20130140177
    Abstract: The present disclosure relates to a removable assay cartridge containing a polymer body with channels for fluid movement for an in vitro medical diagnostic device. The device also includes a removable calibration fluid cartridge.
    Type: Application
    Filed: December 6, 2012
    Publication date: June 6, 2013
    Applicant: Edan Diagnostics
    Inventor: Edan Diagnostics
  • Publication number: 20130140178
    Abstract: The measurement device comprises a sensor holder to which is removable to a biosensor. The sensor holder has measurement-use connection terminals that are in contact with the electrode system in the biosensor and are used to take off signals required for measuring the specific component, and thermocouple-use connection terminals that are in contact with the thermocouple in the biosensor and are used to take off the thermoelectromotive force signals.
    Type: Application
    Filed: December 7, 2012
    Publication date: June 6, 2013
    Applicant: PANASONIC CORPORATION
    Inventor: Panasonic Corporation
  • Publication number: 20130118899
    Abstract: Electrochemical blood test strips and diagnosis systems are presented. An electrochemical blood test strip for measuring HCT % and prothrombin time includes an electrode plate having electrode circuit patterns on an insulator substrate; a separation plate disposed on the electrode plate defining a blood sample region, a channel and three reaction regions; and a cover plate disposed on the separation plate having a blood sample inlet and vents. In measuring, one of the three reaction regions is used for detecting hemoglobin and hematocrit and the other two reaction regions are biochemical reaction regions and used for detecting prothrombin time.
    Type: Application
    Filed: June 22, 2012
    Publication date: May 16, 2013
    Applicant: APEX BIOTECHNOLOGY CORP.
    Inventors: Sz-Hau CHEN, Yi-Chen LU, Chun-Yi YEN
  • Publication number: 20130105313
    Abstract: There is provided a biosensor which includes: a substrate formed of an insulator; a set of electrodes provided on the substrate; a reaction part provided on the set of electrodes; a supply port for introducing blood (a specimen) to the reaction part; an attachment part for connecting the set of electrodes to a terminal of a measurement display; and a picking plate having a picking part to be picked up, the picking plate extending to a side opposite from the attachment part with respect to the reaction part and being bent in a cross-sectional direction perpendicular to the extending direction.
    Type: Application
    Filed: July 8, 2011
    Publication date: May 2, 2013
    Applicant: GUNZE LIMITED
    Inventors: Takafumi Tanaka, Hideki Tanaka, Hideki Sato
  • Patent number: 8430999
    Abstract: The present invention relates to an analytical tool 1 which includes a flow path for moving a sample, and a working electrode 15 and a counter electrode 16 including active portions 15c, 16c, 16d for coming into contact with the sample supplied to the flow path and which is mounted in use to an analytical apparatus. The active portions 16c, 16d of the counter electrode 16 include a first active portion 16c and a second active portion 16d divided within the flow path. The working electrode 15 and the counter electrode 16 include contact ends 15a, 16a for coming into contact with terminals of an analytical apparatus when the analytical tool 1 is mounted to the analytical apparatus. At least one of the working electrode 15 and the counter electrode 16 includes a first electrode portion 16B which includes the contact end 16a and the first active portion 16c and a second electrode portion 16C which includes the second active portion 16d.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: April 30, 2013
    Assignee: Arkray, Inc.
    Inventors: Kazuteru Onoda, Yoshiharu Sato
  • Patent number: 8425743
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: April 23, 2013
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Patent number: 8425757
    Abstract: A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated amperometric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed gated amperometric pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, under-fill, temperature changes in the sample, and a single set of calibration constants.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: April 23, 2013
    Assignee: Bayer HealthCare LLC
    Inventors: Huan-Ping Wu, Christine D. Nelson, Greg P. Beer
  • Publication number: 20130087455
    Abstract: This invention discloses a biosensor test strip that comprises a substrate, on which lies a conductive layer that contains a plurality of contact pads, check pads and reaction zones, which contains a plurality of working and reference electrodes, and on which the reaction reagent is deposited. The first contact pad is connected to the working electrode, while the second contact pad is connected to the reference electrode. Furthermore, this invention discloses a biosensor test strip for multiple tests on a single strip. The biosensor test strip includes a substrate with a plurality of incisions to divide the substrate into a plurality of individual test sections.
    Type: Application
    Filed: October 4, 2012
    Publication date: April 11, 2013
    Applicant: JOINSOON MEDICAL TECHNOLOGY CO., LTD.
    Inventor: Joinsoon Medical Technology Co., Ltd.
  • Patent number: 8409382
    Abstract: A method for producing an analytical consumable is proposed. The analytical consumable comprises at least one carrier and at least one analytical aid connected to the carrier. At least one optically sensitive material is applied to the carrier, said material being designed to carry out at least one optically detectable alteration in the event of action of an electromagnetic radiation. In at least one coding step, at least one function information item about the analytical consumable is introduced into the optically sensitive material by means of electromagnetic radiation. The function information item is designed to enable at least one analytical instrument to use the analytical consumable correctly.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: April 2, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Wolfgang Schwoebel, Joerg Dreibholz
  • Patent number: 8409424
    Abstract: An electrochemical test strip, an electrochemical test system, and a measurement method using the same are provided. The electrochemical test strip includes an insulating substrate, an electrode system formed on the insulating substrate, and an insulating layer formed on the electrode system. The electrode system includes a set of measurement electrodes, a set of identifying electrodes, and a resistive path having a predetermined resistance value. The set of identifying electrodes is made of metal material, and the resistive path is made of non-metal material. The set of measurement electrodes includes a reference electrode and a working electrode insulated from each other, and the set of identifying electrodes includes a first identifying electrode and a second identifying electrode connected with each other through the resistive path.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: April 2, 2013
    Assignee: Apex Biotechnology Corp.
    Inventors: Guan-Ting Chen, Yueh-Hui Lin, Kai-Tsung Teng, Sz-Hau Chen, Thomas Y. S. Shen
  • Publication number: 20130075278
    Abstract: Apparatus and methods are described for preparing, maintaining, and stabilizing sensors. The apparatus and methods for preparing sensors for use are utilized in advance of the sensor being removed from a sealed, sterilized package. The apparatus include packaging materials having electrical circuits capable of stabilizing a sensor to prepare the sensor for use. The methods for preparing a sensor for use includes methods of providing a solution to a sterilized packaging that contains a sensor connected to a sensor activating circuit, activating the circuit, and allowing the sensor to stabilize. These methods can be performed without compromising the packaging. The apparatus for stabilizing a sensor that is in use include a circuit connectable to the sensor that provides a signal to the sensor that prevents the sensor from becoming destabilized when disconnected from a monitoring device.
    Type: Application
    Filed: March 26, 2012
    Publication date: March 28, 2013
    Applicant: Edwards Lifesciences Corporation
    Inventors: Michael Higgins, Mark Konno, Todd Fjield
  • Publication number: 20130062221
    Abstract: A disposable biosensor for determining the content of hemoglobin and hematocrit in a sample of whole blood that includes a laminated strip with a first and second end, at least a reference, a working electrode and a blank electrode embedded in the laminated strip. The working electrode contains a reagent sensitive to hemoglobin or hemotocrit. The blank electrode is used to measure oxidizable species in the fluid sample and to correct the current signal of the working electrode. The construction of the biosensor allows accurate measurement of the impedance of a small fluid sample, which is used to further correct the current signal of the working electrode.
    Type: Application
    Filed: September 12, 2011
    Publication date: March 14, 2013
    Inventors: Xiaohua CAI, Chung Chang Young, Jessica Joy MOKFIENSKI
  • Patent number: 8394246
    Abstract: A remote measurement system measures the concentrations of analytes in fluid samples. The system includes a metering device that can receive signals from a test strip or alternatively interrogate the test strip to obtain information. The test strip includes an area for receiving a fluid sample and electrochemically producing a current response that is sensed within the fluid sample. The test strip also includes an antenna and a radio frequency signal circuit for transmitting a signal indicative of the current response of a fluid sample to be analyzed. The metering device receives the signal and can convert it into a readable display in some embodiments. Remote electrochemical analysis of a fluid sample is thereby obtained.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: March 12, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Michael J. Celentano, P. Douglas Walling
  • Patent number: 8388821
    Abstract: Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator.
    Type: Grant
    Filed: October 5, 2007
    Date of Patent: March 5, 2013
    Assignee: LifeScan Scotland Limited
    Inventors: Stephen Patrick Blythe, Marco F. Cardosi, Andrew Gill, Leanne Mills, Christopher Philip Leach
  • Publication number: 20130043142
    Abstract: Methods and systems for measuring the oxidation-reduction potential of a fluid sample are provided. The system includes a test strip with a sample chamber adapted to receive a fluid sample. The sample chamber can be associated with a filter membrane. The test strip also includes a reference cell. The oxidation-reduction potential of a fluid sample placed in the sample chamber can be read by a readout device interconnected to a test lead that is in electrical contact with the sample chamber, and a reference lead that is in electrical contact with the reference cell. Electrical contact between a fluid sample placed in the sample chamber and the reference cell can be established by a bridge. The oxidation-reduction potential may be read as an electrical potential between the test lead and the reference lead of the test strip.
    Type: Application
    Filed: October 24, 2012
    Publication date: February 21, 2013
    Applicant: INSTITUTE FOR MOLECULAR MEDICINE, INC.
    Inventor: INSTITUTE FOR MOLECULAR MEDICINE, INC.
  • Publication number: 20130035573
    Abstract: There are provided a biosensor, and a measurement device in which the biosensor is used, with which accurate puncture is enabled and reliability of measurement results are improved. The biosensor (4) comprises an element substrate (9), a detector (10), a connection terminal (11), a continuity path (12), and a cutout (13). The detector (10) is provided over the element substrate (9), and receives a specimen and detects a specific component contained in the specimen. The connection terminal (11) is provided over the element substrate (9) and acquires current corresponding to the specific component. The continuity path (12) connects the connection terminal (11) and the detector (10). The cutout (13) is formed along the outer periphery of the detector (10) so as to surround two or more directions of the detector (10).
    Type: Application
    Filed: June 20, 2011
    Publication date: February 7, 2013
    Inventor: Masaki Fujiwara
  • Publication number: 20130032494
    Abstract: Portable device (1) for analysing pH or another variable by electrochemical measurement comprising a sensor (2), a microprocessor (3) and display means (4) for the results of the analysis. The portable device makes it possible to carry out pre-diagnoses quickly and easily without the need for specialist staff.
    Type: Application
    Filed: December 14, 2010
    Publication date: February 7, 2013
    Inventors: Isabel Gomila Muñoz, Feliciano Grases Freixedas, Antonia Costa-Bauza, Rafael M. Prieto Almirall, Eva Martín Becerra, Bernat Isern Amengual, Ruben Henríquez Peláez, Joan Perelló Berstard
  • Patent number: 8361291
    Abstract: The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: January 29, 2013
    Assignees: Roche Diagnostics Operations, Inc., Roche Operations Ltd.
    Inventors: Michael J. Celentano, Henning Groll, James L. Pauley, Steven K. Moore
  • Patent number: 8357273
    Abstract: The present invention relates to an analyzer (1) to be used with an analytical tool (2) mounted thereto and used for analyzing a particular component contained in a sample supplied to the analytical tool (2). The analyzer (1) includes at least one detection terminal pair (11, 12) including a first and a second detection terminals (11A, 11B, 12A, 12B) which are capable of selecting a mutually contacting state and a non-contacting state, a detector (15) for detecting the state of contact of the first and the second detection terminals (11A, 11B, 12A, 12B), and an abnormality detector (16) for detecting an abnormality of the at least one detection terminal pair (11, 12) based on the detection result by the detector (15).
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: January 22, 2013
    Assignee: Arkray, Inc.
    Inventor: Takuji Kawai
  • Patent number: 8349157
    Abstract: A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: January 8, 2013
    Assignee: Panasonic Corporation
    Inventors: Shoji Miyazaki, Hiroyuki Tokunaga, Masaki Fujiwara, Eriko Yamanishi, Yoshinobu Tokuno
  • Publication number: 20130001103
    Abstract: Methods for distinguishing between an aqueous non-blood sample (e.g., a control solution) and a blood sample. In one aspect, the methods include using a test strip in which multiple current transients are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or an aqueous non-blood sample based on at least two characteristics (e.g., amount of interferent present and reaction kinetics). The method can also include calculating a discrimination criteria based upon at least two characteristics. Various aspects of a system for distinguishing between blood samples and an aqueous non-blood sample are also provided herein.
    Type: Application
    Filed: September 12, 2012
    Publication date: January 3, 2013
    Applicant: LifeScan, Inc.
    Inventors: Ronald C. Chatelier, Alastair M. Hodges
  • Publication number: 20120325681
    Abstract: An electrochemical paper-immunosensor and method for detecting aminoglycoside antibiotics is developed in the present invention. Single-walled carbon nanotubes are coated on the common filtration paper by dip-dry cycles. With antibody against neomycin adding to the coating solution, a high sensitive biosensor for specific detection of neomycin is prepared, satisfying to the rigid authority regulations. The sensor is not only sensitive but also rapid, comparing with the classic ELISA method, with LOD of 0.04 ng mL?1 and the whole detection process lasting less than 30 min. Another notable advantage of this invention is the versatility of the sensor, similar method is engaged to prepare the versatile sensor for other aminoglycoside antibiotics, replacement with relevant antibodies.
    Type: Application
    Filed: November 25, 2011
    Publication date: December 27, 2012
    Inventors: Chuanlai Xu, Libing Wang, Xiaoling Wu, Hua Kuang, Wei Chen, Wei Ma
  • Publication number: 20120312699
    Abstract: An analytical test strip and test meter combination for use in the determination of an analyte in a bodily fluid sample includes an analytical test strip and a test meter, and a method for determination thereof. The analytical test strip has an electrode, a first electrical contact pad in electrical communication with the electrode and configured to communicate an electrical response of the electrode to the test meter; and a second electrical contact pad in electrical communication with the electrode and configured to communicate an electrical response of the electrode to the test meter should the test meter be in electrical communication with the second electrical contact pad. In addition, the second electrical contact pad has electrical continuity with the first electrical contact pad and the first and second electrical contact pads are disposed in either of first and second predetermined spatial relationships to one another.
    Type: Application
    Filed: June 7, 2011
    Publication date: December 13, 2012
    Applicant: Cilag GmbH International
    Inventors: Graeme WEBSTER, Peter TEMPLETON, David ELDER, Lawrence RITCHIE, James MOFFAT, Gavin MACFIE
  • Patent number: 8317988
    Abstract: The present invention relates to improved electrochemical biosensor strips and methods for determining the concentration of an analyte in a sample. By selectively measuring a measurable species residing in a diffusion barrier layer, to the substantial exclusion of the measurable species residing exterior to the diffusion barrier layer, measurement errors introduced by sample constituents, such as red blood cells, and manufacturing variances may be reduced.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: November 27, 2012
    Assignee: Bayer HealthCare LLC
    Inventor: Huan-Ping Wu
  • Patent number: 8314613
    Abstract: Disclosed are an electrochemical biosensor which comprises a production lot information identification portion, on which information is recorded in a magnetization mark, and a measuring device which can automatically identify the production lot information of the biosensor with the insertion of the electrochemical biosensor into the measuring device. The electrochemical biosensor and the measuring device thereof can record production lot information in the form of magnetization marks on an electrochemical biosensor strip and read the information as digital signals through a magnetoresistance sensor device, which can be mounted on the surface of a circuit board using Surface Mounted Technology (SMT). Without the need for a high-priced filter or a complicated calculation system, the magnetic detector system has a simple construction and realizes economic efficiency in the construction of the measuring device.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: November 20, 2012
    Assignee: i-SENS, Inc.
    Inventors: Gang Cui, Keun Ki Kim, Dong Hoon Han, Moon Hwan Kim, Hakhyun Nam, Geun Sig Cha
  • Patent number: 8308935
    Abstract: The present invention relates to a bio-sensing device capable of automatically detecting a sensing code and a sensing method thereof. The bio-sensing device has a bio-sensing strip and a process-and-display unit. The bio-sensing strip has a passive component, wherein a physical value of the passive component is able to present a sensing code. When the bio-sensing strip is inserted into the process-and-display unit, the process-and-display unit reads the sensing code to produce an appropriate compensation value of a sample. Moreover, by the sensing method, the process-and-display unit is able to detect the sensing code of the bio-sensing strip, and automatically, to access, calculate, compensate, and display the sensing code of the sample.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: November 13, 2012
    Assignee: R3dstar Biomedical Corp.
    Inventors: Chun-Yu Chen, Chung-Chih Hsiao, Chung-Ping Tang
  • Patent number: 8298387
    Abstract: A reactive oxygen species measuring device according to the present invention comprises a reactive oxygen species sensor provided with an electrode assembly capable of detecting the presence of reactive oxygen species or the like in terms of an electric current, a power source means for applying a measuring voltage to the reactive oxygen species sensor, and a reactive oxygen species concentration measuring means for measuring a concentration of the reactive oxygen species or the like from the current detected by the reactive oxygen species sensor. According to the present invention, a concentration of reactive oxygen species or the like such as in vivo or in vitro superoxide anion radical (O2?.) can be measured reliably, and the entire device can be formed in a smaller size and always mounted to a living body.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: October 30, 2012
    Inventors: Makoto Yuasa, Fumio Mizoguchi, Hitoshi Takebayashi, Masahiko Abe, Masumi Koishi, Shigeru Kido, Masamitsu Nagahama, Masayuki Kawasaki, Masahiko Yokosuka, Takashi Ishihara, Rizwangul Ibrahim
  • Patent number: 8298400
    Abstract: A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: October 30, 2012
    Assignee: Panasonic Corporation
    Inventors: Shoji Miyazaki, Hiroyuki Tokunaga, Yoshinobu Tokuno
  • Patent number: 8293094
    Abstract: A method for monitoring a select analyte in a sample in an electrochemical system. The method includes applying to the electrochemical system a time-varying potential superimposed on a DC potential to generate a signal; and discerning from the signal a contribution from the select analyte by resolving an estimation equation based on a Faradaic signal component and a nonfaradaic signal component.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: October 23, 2012
    Assignee: AgaMatrix, Inc.
    Inventors: Sridhar G. Iyengar, Ian S. Harding
  • Patent number: 8293096
    Abstract: A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: October 23, 2012
    Assignee: LifeScan Scotland Limited
    Inventors: Marco F. Cardosi, Stephen Patrick Blythe, Matthew Finch, Arlene Thompson, Nina Antonia Naylor, Eric Jason Bailey, Michael Patrick Dolan, Gretchen Anderson, Lorraine Comstock, Mary McEvoy, Thomas Sutton, Richard Michael Day, Leanne Mills, Emma Vanessa Jayne Day, Christopher Philip Leach
  • Patent number: 8287703
    Abstract: An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: October 16, 2012
    Assignees: Roche Diagnostics Operations, Inc., Roche Operations Ltd.
    Inventors: Raghbir S. Bhullar, Eric R. Diebold, Brian S. Hill, Nigel Surridge, Paul Douglas Walling
  • Patent number: 8287704
    Abstract: A liquid sample measurement apparatus of the present invention is provided with a timer for measuring the time from when a biosensor is attached to a liquid sample measurement device which measures the concentration of a specific component in a liquid sample that is applied to the biosensor to when the liquid sample is applied to the biosensor, and correction based on the time measured by the timer is performed to the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor. Thereby, the measurement precision can be enhanced with utilizing the correction algorithm in which the ambient temperature and the temperature of the biosensor itself are considered.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: October 16, 2012
    Assignee: Panasonic Corporation
    Inventors: Teppei Shinno, Yoshifumi Takahara
  • Patent number: 8287718
    Abstract: A liquid sample measurement apparatus of the present invention is provided with a timer for measuring the time from when a biosensor is attached to a liquid sample measurement device which measures the concentration of a specific component in a liquid sample that is applied to the biosensor to when the liquid sample is applied to the biosensor, and correction based on the time measured by the timer is performed to the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor. Thereby, the measurement precision can be enhanced with utilizing the correction algorithm in which the ambient temperature and the temperature of the biosensor itself are considered.
    Type: Grant
    Filed: July 4, 2007
    Date of Patent: October 16, 2012
    Assignee: Panasonic Corporation
    Inventors: Teppei Shinno, Yoshifumi Takahara
  • Patent number: RE44330
    Abstract: This invention relates to a biosensor and more particularly to an electrochemical biosensor for determining the concentration of an analyte in a carrier. The invention is particularly useful for determining the concentration of glucose in blood and is described herein with reference to that use but it should be understood that the invention is applicable to other analytic determinations.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: July 2, 2013
    Assignee: LifeScan Inc.
    Inventors: Alastair M. Hodges, Thomas W. Beck, Oddvar Johansen