Abstract: A pharmaceutical formulation includes (1) a first dosage component comprising: a core comprising a non-ionic polymer matrix, a first amount of ondansetron or an equivalent amount of an ondansetron salt thereof dispersed within the matrix, and an electrolyte dispersed within the matrix; a first seal coat surrounding the core, the first seal coat comprising a non-ionic polymer matrix; and an immediate release drug layer surrounding the first seal coat, wherein the immediate release drug layer comprises a non-ionic polymer and a second amount of ondansetron or an equivalent amount of an ondansetron salt thereof dispersed therein; and (2) a second dosage component comprising: a core comprising a third amount of ondansetron or an equivalent amount of an ondansetron salt thereof, at least one filler, and a lubricant; and a coating surrounding the core, the coating comprising water and a mixture of methacrylic acid-alkyl acrylate copolymers with alkaline groups.

Abstract: Compositions that include antimicrobial agents and biodegradable delivery vehicles adapted to enter a cell and release the antimicrobial agents in the cell as they biodegrades. Also provided are compositions that include first and second delivery vehicles including first and second antimicrobial agents, wherein the first delivery vehicles are adapted to release the first antimicrobial agents at a rate that differs from that at which the second delivery vehicles release the second antimicrobial agents, articles of manufacture that include one or more biodegradable delivery vehicles, and methods of making and using the compositions to treat intracellular and/or extracellular infections are disclosed.

Abstract: A surgical apparatus for use by a surgeon can include a tray and a plurality of surgical instruments. The tray can have a plurality of structures located on an upper side of the tray for receiving the plurality of surgical instruments. The tray can receive a separate control unit. The tray can also have a fluid reservoir receiver for receiving a bottle or container of fluid, such as balanced salt solution. The fluid reservoir receiver can include one or more features, including, a spike, an air vent, and a light. A separate container can be used to place the bottle or container of fluid into the fluid reservoir receiver on the tray. This separate container can include a collapsible section.

Abstract: A system comprising at least: a first container containing at least a first surgical instrument of a first type that is size specific and a second surgical instrument of a second type that is size specific, wherein both the first and second instruments are of a first size; a second container containing at least a third surgical instrument of the first type and a fourth surgical instrument of the second type, wherein both the third and fourth instruments are of a second size which is different from the first size; and a third container containing at least a fifth surgical instrument of a third type which is size independent. The system allows instrumentation to be grouped and stored so that the number of instruments opened but not used in complex surgical procedures is reduced.

Abstract: Embodiments described herein generally relate to improved devices, systems, kits, products and methods related to topical medicament application of measured dosages. The kits and devices can single use and/or disposable for example.

Abstract: Methods and systems for improving the shelf life of a medical graft generally comprising a medical implant container having at least one graft cavity configured to hold at least one graft under a first vacuum and a needle entry port in fluid communication with the at least one graft cavity, the needle entry port being configured to receive and communicate a material to the at least one graft cavity and an outer chamber configured to hold the medical implant container under a second vacuum.

Abstract: The invention provides a housing adapted to provide for the juxtaposition of an oral hygiene device, such as a toothbrush, with an inhaler medication device, such as a metered dose inhaler (MDI) or dry powder inhaler (DPI). Also provided is an assembly including a housing, an oral hygiene device and an inhaler medication device wherein, in use, the housing and inhaler medication device together secure the oral hygiene device in the housing such that the oral hygiene device cannot be removed for use without first removing the inhaler medication device.

Abstract: A heating device includes a housing, a thermally conductive receptacle, a cover, a heating element, a temperature sensor, a user interface and a power source. The thermally conductive receptacle is disposed within the housing and is accessible through an opening. The thermally conductive receptacle is sized to receive, completely contain and heat a container containing a product used in sexual activities. The cover is attached to the housing and is disposed over the opening to provide access to the thermally conductive receptacle and enclose the container containing the product. The heating element is disposed within the housing, and is connected to the thermally conductive receptacle. The temperature sensor is disposed within the housing and is connected to the heating element or the thermally conductive receptacle. The controller is disposed within the housing and is electrically connected to the heating element, the temperature sensor, and the user interface.

Abstract: The invention relates to a contraception kit that includes at least one regular contraception for the female cycle as well as an emergency contraception. The invention is characterized in that both types of contraception are included in a common packaging.

Abstract: The present invention provides a patty manager having a dispensing tray including one or more dispensing regions for receiving surgical patties, and a recovery tray having a plurality of recovery regions for receiving surgical patties. Each dispensing region may include a dispensing indicia located, and each recovery region can include a recovery indicia, which may correspond to a substantially similar dispensing indicia of the dispensing tray. A string guide may be disposed about at least a portion of the dispensing regions for the organization and management of the patty strings. A gripping tool may further be coupled to one of the dispensing or recovery trays.

Abstract: A kit including a packaging material and a solid pharmaceutical or nutraceutical product, and in particular for a solid, opioid-based pharmaceutical product. The packaging material has an inner surface and an outer surface that avoids contamination of the product. At least that part of the inner surface, which is exposed to the pharmaceutical or nutraceutical product, is made of or covered with an inert material selected from the group made of polyamide, polyethylene terephthalate and epoxy resin-coated aluminium.

Abstract: To provide a medical tray which can be made more compact upon discarding, the medical tray has a bottom portion, a side wall provided along an outer periphery of the bottom portion, and a pair of side wall deformation guiding portions provided at opposing positions of the side wall for guiding the side wall when the side wall is deformed into a convex state toward the bottom portion.

Abstract: A brachytherapy packaging system is disclosed including an inner tray containing a plurality of recesses, each recess for holding a strand of linked radiological seeds separated by spacers. An inner tray cover may also contain a plurality of recesses that coincide with the recesses of the inner tray when placed over the inner tray. The inner tray and inner tray cover may be supported by and enclosed in a container made out of a metal such as pewter. A retainer may also be supportable on the top of the container, shaped for holding a forceps or tweezers. An outer tray may be used for supporting and enclosing the container and optional retainer. The outer tray may be sealed with a removable sheet adhesively attached to a rim of the outer tray. Different configurations of the inner tray and inner tray cover may be used for different packaging configurations.

Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.

Abstract: The present invention relates to novel smart packaging, designed using a novel material comprising a partially polar adsorbent solid base impregnated with a solution of vanillin, which allows the growth of microorganisms in different types of products to be detected visually without having to be in direct contact with the microorganism or with the medium containing same.

Abstract: A multiple medicament container and method for retaining a plurality of medicaments for students on excursions from school is disclosed. The container is configured to securely hold medicaments of a variety of configurations including epinephrine pens and asthma inhalers as well as other forms. The container also holds cards identifying medical conditions relating to each student for which medicaments are provided as well as cards denoting administration protocols for each medicament loaded into the container. A single medicament embodiment of the container is also disclosed wherein the container is already paired to the subject student.

Abstract: A kit for the storage and transportation of medical equipment (31) following processing or use thereof contains, as its principal component, a tray (10) defined by a base (12) and surrounding walls (13, 14). The tray (10) has at least one fold line (19) formed in the base and/or walls (13, 14), thereby to facilitate compaction of said tray (10) for disposal. Optional further components of the kit include: a tray line (28); a protective cover (34) adapted to be detachably secured to the tray (10); a lid (23) adapted to engage with the walls (13, 14) of the tray (10); and an oxygen-impermeable container (37) adapted to receive said tray (10) therewithin.

Abstract: The invention provides an oral composition comprising a pharmaceutically acceptable carrier, at least one antacid, an inorganic matrix comprising at least silicon dioxide and titanium dioxide, and an anaesthetic, wherein the composition is substantially evenly dispersed in the carrier and is palatable.

Abstract: A sampling system and method may use a kit that has a package enclosing a swab and a receptacle. The swab may have a shaft and a tip. The tip may be substantially made of calcium alginate. The receptacle may contain a diluent, such as sodium citrate, and glass beads. The swab may be used in an environment to sample microorganisms present on surfaces or in equipment. The kit may be used in a method of sampling and the resulting sample may be used in a method of quantitative testing.

Abstract: A hand-held applicator is defined for applying a viscous product, such as a pharmaceutical product to the skin. The applicator includes a substrate with a flat face defining multiple dosing areas of the product. The product can be dispensed from a tube in a first area for a first recommended dosage and in combination in a first area and a second area for a second recommended dosage. Once the desired dosage is dispensed, the applicator is used to apply to product to an affected area of the skin.

Abstract: A system includes a first container having a wall defining a receptacle, a neck defining an opening, and a flip cap disposed over the opening, and a second container having a wall defining a receptacle, a neck defining an opening, and a flip cap disposed over the opening. The system also includes a carrier having first and second carrier pieces disposed about the first and second containers and attached together with the first and second containers secured therebetween. The system further includes a top cap attached to the flip caps to secure the first and second containers together and to simultaneously remove the flip caps from the containers.

Abstract: A modular instrument kit configured to receive a plurality of instrument trays therein. At least one of the trays includes a planar base, a rear wall orientated at an angle relative to the base, a flange, and an instrument support configured to support a plurality of surgical instruments. The at least one tray is configured to be seated on a generally planar surface in a free-standing position to support the plurality of surgical instruments such that tips of the instruments extend upward so as to be readily viewable in an operating room. The at least one tray is configured to be hung from a generally vertical surface with the rear wall generally flush against a first surface of the generally vertical surface and the flange in contact with a second surface of the generally vertical surface that is opposite to the first surface.

Abstract: A surgical screw cartridge system apparatus and method is provided wherein the cartridge has a body for storing a plurality of surgical screws. A spring-biased plunger is positioned within the body for presenting the surgical screws head first to a driver. A tab within the body prevents removal of the surgical screws from the body in absence of a screwdriver.

Abstract: The present invention is a first aid emergency supply kit capable of providing audio and/or video instructions to the user as to how to use the medical supplies contained in the kit. The case is organized so that the medical supplies for different traumas are packaged into individual bags. The user can activate the audio and/or video instructions by pushing a button on the unit's console that corresponds to the particular trauma. Alternatively, the instructions can be activated by removing a bag from the case which automatically begins the instructions. If a victim has sustained multiple injuries, and the user has depressed multiple buttons or removed multiple bags, then the device automatically prioritizes the traumas and provides instructions on the multiple traumas in the proper order.

Abstract: A compartmentalized protective case houses a portable electronic device and personal care items that are organized and held securely therewithin. The compartmentalized protective case has a major compartment for receiving and housing an electronic device such as a smart phone, cellular phone, music player, or other digital media device. At least one cell compartment constructed within the case receives and houses personal care items removably integrated therein. Personal care items include a plurality of interchangeable replacement cells containing beauty items, cosmetics, hygienic items, oral care products such as floss or breath strips, medications, vitamins, breathe fresheners and/or health care products. A second cell compartment is preferably provided as a removable pouch or restraining system for holding identification cards, currency, visa or bank cards, and/or keys.

Abstract: A process for the treatment or processing of containers is provided. The process includes automatically conveying the containers past a processing station for the treatment or processing by or through a conveying device and then inserting the containers into a transport or packaging container having a bottom, a circumferential side wall and an insertion opening opposite to the bottom. In some embodiments, a plurality of containers are placed on a flat supporting base so that the bottoms of the containers directly rest on the flat supporting base; the containers, while resting on the flat supporting base, are conveyed to a processing station by the conveying device to be treated or processed; and after the treatment or processing of the containers, the transport or packaging container is placed on the flat supporting base so that all the containers of the plurality of containers are accommodated in the transport or packaging container.

Abstract: A custom procedure kit is provided, which comprises a plurality of medical-procedure tools and a cover that is wrapped around the plurality of medical-procedure tools to form wrapped tools. An outer container is fully disposed about the wrapped tools, and at least one sheet is disposed between the outer container and the wrapped tools. The sheet includes a listing of the plurality of medical-procedure tools and, for at least some of the medical-procedure tools, an unselected end-user selectable field.

Abstract: A package in the form of a bag containing a medical product, in particular for use in the regenerative treatment of cartilage damage in humans or animals, the package having a component preferably in the form of a port, to fill the package with a liquid, preferably a cell-containing liquid.

Abstract: A tray (100) for accommodating a coiled medical device, such as a catheter assembly (700), includes a first compartment (101), a second compartment (102), and a third compartment (103). The catheter assembly (700) and devices associated with a catheterization procedure, such as syringes (701,702) containing sterile water and lubricating jelly and a specimen container (703) can be disposed within the tray. A first barrier (105) and second barrier (106) separate the compartments. The barriers can have openings (121,122) therein to accommodate large syringes or to enable the first compartment (101) to be used as a lubricant applicator for the catheter. The first compartment (101) can include a stair-stepped contour (115) such that the syringes are held at different depths to facilitate ease of use. The various devices can be disposed within the tray (100) in accordance with their order of use in the catheterization procedure.

Abstract: An orthopedic fixation system includes a sterile packaged implant kit and a sterile packaged instrument kit. The sterile packaged implant kit includes at least one surgical implant, an insertion device, and an implant package adapted to receive the at least one surgical implant and the insertion device therein. The implant package maintains the at least one surgical implant and the insertion device sterile after sterilization of the sterile packaged implant kit. The sterile packaged instrument kit includes one or more instruments necessary to use the sterile packaged implant kit and an instrument package adapted to receive the one or more instruments therein. The instrument package maintains the one or more instruments sterile after sterilization of the sterile packaged instrument kit.

Abstract: A biodegradable film (4) characterized in that it is prepared from at least one co-product derived from a soya bean-processing process aimed at obtaining soya-based final products by ultrafiltration, said co-product being selected from the group comprising the okara and the permeate. Such a film can be used as a food or pharmaceutical film, in particular for preparing a product for topical administration (1) of a pharmaceutical active ingredient, such as oestrogens.

Abstract: A container holds at least one surgical implement, has a lock mechanism, and has a signature label that impedes access to the surgical implement until the correct surgical site is confirmed. A method of using the container includes the steps of confirming the correct surgical site, signing the label and removing it from the container, placing the label in the medical record, unlocking the container, removing the implement, and beginning the surgery, wherein the surgical team is forced to pause to confirm the correct surgical site before starting the surgery. Preferably, the container top may be removed and placed between the surgeon and surgical technician to define a no-hands “neutral zone” to avoid being stuck by the sharps. Also, the container preferably includes compartments for storing used sharps and/or a local anesthetic-loaded syringe, and the top may be replaced and secured for safely disposing of the sharps after the surgery.

Abstract: A life support algorithm display system for providing convenient access to basic life support or advanced life support algorithms for a user during an emergency features an I.V. (intravenous) pole located on a base. The system features a plurality of rectangular life support algorithm cards with a tab located on a card bottom edge. A life support algorithm is printed on each card. The system features a plurality of display modules each having a side arm attached to a clip. The clip is adapted to snugly, yet pivotally clip onto the I.V. pole allowing the display module to rotate around the I.V. pole. Each life support algorithm card is located in a display module with the tab passing through a module bottom aperture. Each display module is clipped onto the I.V. pole and adapted to be rotated for viewing.

Abstract: Disclosed are surgical kits and methods of making a surgical device for proximation of body parts. An exemplary method comprises receiving a ferrule defining a ferrule axis, the ferrule being received a room temperature; sterilizing the ferrule received in the previous step; receiving a sleeve defining a sleeve axis. The sleeve includes a projection configured to exert a force, parallel to the sleeve axis, against the ferrule, the sleeve being received at room temperature; and sterilizing the sleeve.

Abstract: The present invention provides pharmaceutical formulations comprising an antibody that specifically binds to human delta-like ligand 4 (Dll4). The formulations may contain, in addition to an anti-Dll4 antibody, a phosphate buffer, an organic cosolvent, a disaccharide, and a salt.

Abstract: A handling baggage, constituted from a trolley or a suitcase, equipped of a couple of sliding shoes in elastic material, able to slide on stairs, facilitating the crossing.

Abstract: Embodiments of the present invention include a sealable kit having a sterile removable covering sealed over a sterile first well and a non-sterile foldable flap cover over one or more medicament wells. The foldable flap cover may be opened and closed independently of the sterile removable cover permitting the packaging to be opened to allow the removal of expired medications without opening the sterile covering over the first well. In another embodiment, the foldable flap cover is at least partially transparent so medications within the medicament well may be viewed when the foldable flap is in the closed position.

Abstract: Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness.

Abstract: An orthopedic fixation system includes a sterile packaged implant kit and a sterile packaged instrument kit. The sterile packaged implant kit includes at least one surgical implant, an insertion device, and an implant package adapted to receive the at least one surgical implant and the insertion device therein. The implant package maintains the at least one surgical implant and the insertion device sterile after sterilization of the sterile packaged implant kit. The sterile packaged instrument kit includes one or more instruments necessary to use the sterile packaged implant kit and an instrument package adapted to receive the one or more instruments therein. The instrument package maintains the one or more instruments sterile after sterilization of the sterile packaged instrument kit.

Abstract: A germ/barrier travel kit sized, shaped and configured to carry articles necessary for germ prevention and sterilization. In one embodiment, the germ/barrier travel kit consists of a bag/container including but not limited to: toilet seat cover, face mask, gloves, head rest cover and hygiene/disinfecting wipes. However, the germ/barrier travel kit may also be configured to carry additional wipes or barriers. The germ/barrier travel kit is configured to permit ready and easy access to articles needed by travelers to defend against germs and preventing disease transmission.

Abstract: This invention provides a slim crash kit and methods of use. The kit includes a combination of resources to address requirements of passengers on the interior of a vehicle after a crash. The kit includes tools aiding in egress and first aid materials in a slim container storable in thin spaces reachable by the passenger from the seated position.

Abstract: Combination beverage containers and storage vessels. Various embodiments are configured to store a consumable beverage or otherwise consumable liquid as well as at least one second item which may comprise an edible foodstuff, toy, novelty, etc. all in one convenient container. In some embodiments, the second items may be stored directly in the vessel separated from the liquid or the second items may be stored in a second container that may be removably seated in a portion of the vessel or in a lid that, once installed on the body, is not removable by the end user. The vessels may or may not be hand-held.

Abstract: Disclosed is a combination medical case including multiple storage compartments, specifically for use by a diabetic patient. The medical case comprises a base compartment sized and shaped to contain a plurality of storage cubicles for the containment of prescription medicine bottles. The base compartment further contains a means for attachment of a planar-shaped equipment tray which may hold a glucose meter and a quantity of syringes or other supplies. A removable drawer, having a hinged top, rests on parallel supporting ledges integral to the inner walls of the base compartment. A shelf is sized and shaped to horizontally fit atop the removable drawer, within the confines of the base compartment. Receptacles within either the base compartment or the drawer may contain a pharmaceutical formulation comprising insulin. The medical case allows the patient to access needed medical and nutritional supplies and access equipment necessary to monitor and/or control his/her glucose level.

Abstract: We provide IDH1 gene-defective cell lines (e.g., IDH1R132H heterozygous and IDH1R132H homozygous) derived from dissociated human astrocytoma samples. The cells can be used alone or in combination with each other or other cell types as a tool for determining the impact of IDH1R132H on cellular biology, tumorigenesis, and metabolic profiles. The cell lines may be used to test and identify therapeutic targets and to screen for molecular therapeutic agents.

Abstract: A ready-for-use surgical kit and a facilitated protocol for the implantation of acetabular prosthesis in hip replacement surgery have been introduced. In particularly, a ready-for-use package includes both a set of the artificial acetabular prosthesis and a set of specific reamer(s) with a predefined spherical cutting profile. According to a protocol, surgeon could accurately select a package including both a size of acetabular prosthesis and a corresponding finishing reamer according to a pre-measurement and bone condition of a respective patient, and then patient-specifically remedy a defected acetabulum into a full hemispherical form having a personalized dimension by the reamer(s) within the package during operation.

Abstract: An element dispensing package suitable for dispensing adhesive strips or bandages. Each element is contained within an envelope formed by opposed upper and lower sheets. The lower sheet has a release liner secured thereto to protect the element while it is within the dispenser. The element is releasably secured to a pull cover and is separated from the lower sheet and release liner when the envelope is opened. The pull cover has one or more gripping means to facilitate dispensing of the element contained within the package. Additionally, the lower sheet and upper sheet have optional gripping means to facilitate dispensing of the element contained within the package.

Abstract: The present invention relates to pharmaceutical compositions comprising a combination of a therapeutically-effective amount of the antiviral compound famciclovir and a therapeutically-effective amount of the COX-2 inhibitor diclofenac. The invention is further related to methods of treating functional somatic syndromes by administering a therapeutically-effective combination of famciclovir and diclofenac.

Abstract: A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a disintegrant, a surfactant, a binder, and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Processes of preparing pharmaceutical compositions comprising Compound 1 are also disclosed.

Abstract: The invention concerns a kit for protecting dressings and/or traumatized skin regions of the body. The kit includes a case containing at least one non-dedicated flexible and water-impermeable base sheet or global sheet with dimensions enabling a plurality of single or individual adapted covering parts to be cut out. The base sheet is preferably made of a non-allergenic material and easily divisible into pieces or fractions of smaller dimensions, for example with a pair of scissors. The kit also includes a package containing a water-impermeable and non-allergenic pasty adhesive, having properties enabling adherence both to the skin and to the protective sheet.

Abstract: A container for housing an injectable fluid vial. The container includes a calculation aid formed specific to the injectable fluid vial. The container is formed from a bottom, a top, and an inset side wall therebetween with a resealable lid. The top includes an opening constructed and arranged to receive the fluid vial housing. Alternatively, the container is formed from two half sections that are hinged together for holding the fluid vial housing therebetween. An inner label is permanently attached to the sidewall having at least one row of dosing indicia coordinated with a base line indicia selected from the group of weight, age, fluid volume or area. An outer label is rotatably secured over said inner label with at least one transparent window allowing selective viewing of the dosing and base line indicia and predetermined dosing rate.