Abstract: Liquid container with a predetermined break point (4), which is covered by an elastomer septum (3). The container forms a hollow body (10) made of a single material that is compatible with critical liquids such as medicines. The elastomer septum (3) and the predetermined break point (4) can be pierced by a hollow needle (51) in order to withdraw liquid from the container.

Abstract: A container is provided for the storage and sampling of aqueous samples, such as deionized water samples. The container comprises an enclosure with an open mouth portion that is sealed via a needle penetratable septa. The septa overlies the mouth and seals the enclosure from the outside atmosphere. The septa comprises a foil layer adjacent the mouth that provides a border between the enclosure and the outside atmosphere and a Teflon layer adjacent the sample. A silicone containing layer of the septa is provided intermediate the foil layer and Teflon layer. A cap member may be provided that is detachably and sealingly engaged to the container covering the mouth. A CO2 adsorbent material may be provided in the space existing between the mouth of the enclosure and a cap member.

Abstract: A system includes a cap having an opening, and a septum configured to engage with the cap. The septum includes a first portion having a first width, and a second portion having a second width smaller than the first width. The second portion is sized and shaped to be received by the opening of the cap.

Abstract: At a medicament manufacturer B, a mouth of a vial body 11 or syringe cartridge 51, in which a medicament 16 is sealed with a plug, is enclosed using a cap 15 or 50 under an environment of a predetermined cleanliness (for example, class M6.5 (the JIS method) or higher). In advance of this enclosure, the cap 15 or 51 has been manufactured at a container manufacturer A by molding with a molding material, which is free of any powdery material, under an environment having cleanliness not lower than the predetermined cleanliness. A cap for enclosing a mouth of a vial body or syringe cartridge sealed with a plug and a manufacturing method of the cap can be provided accordingly.

Abstract: A closure cap for medicine containers and the like, having a bowl-shaped outer part made of PE or PP having at least one exposable penetration opening and a sealing element made of a soft plastic covering said opening. In order to obtain a reliable tight connection between the outer part and the sealing element, the sealing element is tightly connected all around to a socket encompassing the circumference thereof by injection into the same, and .the socket is tightly welded around the entire circumference thereof to the outer part or otherwise tightly connected thereto.

Abstract: The invention relates to a device for stopping a container (1) having a neck (12). The device includes a stopper (51) and a plastic cap (52) configured to surround both the stopper (51) and the neck (12). The cap (52) includes a ring (53) that can surround the stopper and the neck when mounted and is provided with a locking tab (537) for locking onto the neck, and a body (54) for handling the ring, provided with an external rib (535) for transmitting a thrust force to the ring and an edge (541) for activating the tab for locking the ring. The ring (53) is provided with a continuous outer peripheral collar (5311), and the handling body (54) is provided with at least one raised element (5431) designed to abut (E4) against the continuous outer peripheral collar (5311) when the edge (541) activates the locking tab (537).

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.

Abstract: The invention relates to a closure cap (1) for receptacles for receiving medical liquids, in particular receptacles filled with infusion solutions, transfusion solutions or liquids for enteral nutrition. The invention further relates to a receptacle (40) for receiving medical liquids, in particular a bottle, comprising such a closure cap. The closure cap (1) according to the invention is characterized by two injection parts (6 and 7) arranged separately from one another, each for injecting an additive. One injection part (6) serves to inject an additive with an injection syringe that has a needle (cannula), while the other injection part (7) serves to inject an additive with a needle-less injection syringe.

Abstract: An over-torque resistant vial and closure assembly includes a vial having an outwardly projecting rib that cooperates with a stop surface provided on a closure. When the closure is threadably coupled to the vial, the stop surface of the closure engages the outwardly projecting rib of the vial so as to prevent over-torquing of the closure onto the vial.

Abstract: A vial and closure assembly including a vial and a closure configured to be threadably coupled to the vial. The vial has an opening end that is defined by a vial rim and at least one thread located proximate to the open end of the vial. The closure includes a top wall with a skirt wall depending from the top wall. A septum pocket is provided in the top wall and is configured to receive a septum positioned therein. A protrusion depends from the top wall, extends into the septum pocket, and is configured to engage the septum so that the septum creates an essentially vapor-tight seal with the vial rim when the closure is threadably coupled to the vial.

Abstract: A closure assembly for mounting on a container includes a base configured for mounting on the container and defining an aperture through which the interior of the container is accessible. The base comprises a perimeter, a separator mounted on and extending across the perimeter with the aperture being formed in the separator, and a valve positioned on the separator. The valve extends across the aperture in the separator, and is openable by the application of pressure on the valve and self-closable upon removal of the pressure from the valve. The assembly also includes a cover for selectively covering the aperture. The cover is mounted on the base and is movable with respect to the base between a closed position and an open position. The closed position is characterized by the aperture not being accessible and the open position is characterized by the aperture being accessible.

Abstract: A closure for a container, e.g., a tube, for a sample, e.g., a biological sample. The closure comprises a cap having a first opening and a second opening, the first opening capable of communicating with the mouth of a container, the second opening sealed by an exterior seal, and intermediate the first opening and the exterior seal, an interior seal. The invention also provides an assembly comprising the closure of this invention and a container. The invention also provides a method for preparing the closure.

Abstract: A collection device and a method for collecting a biological sample, particularly whole blood, includes a separating member to separate the whole blood into its components, and at least reagent positioned to selectively interact with a component of the separated sample. The reagent is able to selectively interact with the plasma/serum, and is prevented from contacting or interacting with the whole blood.

Abstract: The disclosure is directed to a sealing assembly. The sealing assembly includes a cap having a top surface and a bottom surface, an adhesive layer adjacent the bottom surface of the cap, and a septum adjacent to the adhesive layer. The adhesive layer includes a self-bonding silicone composition and the septum includes at least one fluoropolymer layer. The disclosure is further directed to methods for making the aforementioned sealing assembly.

Abstract: A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.

Abstract: A drug solution transferring device that can suppress dispersion of a toxic drug solution to a surrounding environment is provided. The drug solution transferring device includes a barrel provided with an opening, and a connection tool for connection to the barrel. The barrel includes an elastic member for closing the opening. The elastic member is formed of a plurality of membranes overlaid together. The membrane has a projection projecting into the barrel. The connection tool includes a first needle having a sharp tip end. The first needle has a liquid hole extending in an extending direction of the first needle. When the needle penetrates through the projection of the membrane, an inside and an outside of the barrel are in communication with each other through the liquid hole to allow transference of the drug solution between the barrel and the connection tool.

Abstract: The invention comprises a novel apparatus for delivering a nutritive substance comprising a container body having a base at one end, an upper portion adapted for removable receipt of a closure, the upper portion defining an opening therein, and a chamber defined by the container body, the chamber being in fluid communication with the opening. A laminate seal having at least two layers is bonded across the opening and is adapted to provide an airtight seal across the opening and prevent contact between said nutritive substance and the contents of said container until said seal is altered. The laminate seal comprises a first layer permanently bonded to a rim defining the opening in the upper portion and a second layer that is releasably coupled to the first layer. A nutritive substance is bonded to the first layer. The container additionally comprises a closure removably coupled to the upper portion.

Abstract: A lotion bottle in which different lotions are received for separate use or mixed use is provided. The lotion bottle includes an outer bottle and an inner bottle. Different lotions are received in the outer bottle and the inner bottle respectively. By pushing out a rotating assembly, a lotion received in the inner bottle moves towards a feeding head so as to be mixed with the other lotion received in the outer bottle.

Abstract: Disclosed in this specification is a medicine container with a flexible flap covering the opening of the container. The opening is closed by the flexible flap when the flexible flap is in a resting position and the opening is opened when the flexible flap is in a flexed position. A hand-operated plunger is equipped with an end configured to mate with the opening such that a seal is established between the plunger and the opening. The plunger is shaped to apply a force to the flexible flap, thereby operating the flexible flap.

Abstract: A cap assembly comprising a body, a sealing membrane and a retaining ring. An opening is provided through the body and includes a recessed circumferential channel and a membrane engaging flange positioned proximate the recessed circumferential channel. The sealing membrane covers the opening and includes a body engaging flange and a pierceable surface. The retaining ring is positioned with the sealing membrane engagement surface in overlying engagement with the sealing membrane. Extension of the tab into the recessed circumferential channel of the body releasably maintains the overlying engagement and biases the retaining ring against the membrane. The inner wall structure of the retaining ring extends radially inward beyond the membrane engaging flange of the sealing membrane, to in turn, protect the membrane.

Abstract: A device for limiting sample evaporation. The device has a vessel body having a body exterior surface and at least one body interior surface. The at least one body interior surface has one or more walls defining a first chamber, a second chamber and a conduit means. The first chamber has a first chamber opening for receiving at least one of the groups selected from a sample and a sample dispensing device. The first chamber opening defines the border of the body exterior surface and the body interior surface. The conduit means is in communication with the first chamber and the second chamber for receiving at least one of the group consisting of sample from said first chamber, a sample from a sample dispensing device and a sample dispensing device passing through or into the conduit means for placing the sample in the conduit means or into the second chamber.

Abstract: A pierceable cap maybe used for containing sample specimens during storage and transport. The pierceable cap may prevent unwanted escape of sample specimen before transfer with a transfer device. The pierceable cap may fit over a vessel. An access port in the pierceable cap may allow passage of a tip of a transfer device though the pierceable cap. Multiple frangible layers maybe disposed across the access port. One or more extensions proximate to a lower frangible layer may rotate around one or more coupling regions during insertion of the transfer device. The movement of the one or more extensions may pierce the lower frangible layer to create airways and allow air to escape from a vessel at a reduced velocity. Upper frangible layers may prevent escape of materials from spaces intermediate between the lower frangible layer and the upper frangible layers.

Abstract: A person having diabetes will often be required to take both slow acting and fast acting forms of insulin. It is important to be able to distinguish readily between medicament cartridges containing different medicaments. The present invention enables more ready distinction as between medicament cartridges containing different medicaments.

Abstract: A pierceable cap may be used for containing sample specimens during storage and transport. The pierceable cap may prevent unwanted escape of sample specimen before transfer with a transfer device. The pierceable cap may fit over a vessel. An access port in the pierceable cap may allow passage of a tip of a transfer device though the pierceable cap. A frangible layer may be disposed across the access port. One or more extensions proximate to the frangible layer may be coupled to the pierceable cap by coupling regions or other similar devices. The one or more extension may rotate around the one or more coupling regions during insertion of the transfer device. The movement of the one or more extensions may pierce the frangible layer to create airways and allow air to escape from a vessel at a reduced velocity.

Abstract: The invention relates to a closure cap for a receptacle for receiving medical liquids and to a receptacle for medical liquids which has such a closure cap. The closure cap (1) according to the invention comprises a first connector (2) for the needle-free injection of a medical liquid and a second connector (3) for the needle-free withdrawal of a medical liquid, wherein the first connector (2) has an outwardly directed first connector part (4) with a conical recess (8) for sealingly receiving a cone stem (26) of a first device (28, 29) to be connected, and the second connector (3) has an outwardly directed second connector part (5) with a conical recess (9) for sealingly receiving a cone stem of a second device to be connected.

Abstract: A pierceable, induction sealable seal for a container opening, the seal comprising a plurality of layers at least one of which is metallic and at least one of which is non-metallic, at least one of the non-metallic layers is complete and in use extends across a container opening to seal it. The area over which the at least one of the metallic layers extends is restricted to the region of the periphery of the seal whereby to facilitate induction sealing to the opening but to remain isolated from product in a container upon piercing of the seal.

Abstract: A cap having a plurality of spaced-apart grooves in a downwardly tapered inner wall of the cap to facilitate the formation of air passageways as the cap is penetrated by a pipette tip. The air passageways aid in venting air from a fluid-holding vessel closed with the cap.

Abstract: A female piercing member protection device for connection with a male connection part, and a method for connecting the device to a male connection part. The device includes an outer casing and a connection member at least partly enclosed in the outer casing. The outer casing is moveable between first and second positions. In the first position, the connection member is substantially locked from movement along the longitudinal axis A, and in the second position the connection member is able to move along the longitudinal axis A. The device also has an activated position and an inactivated position. When the outer casing is in the second position, a deformable locking device is prevented from deformation by the outer casing to prevent disengagement of the male connection part. A secure piercing member protection device significantly minimizes the risk for a user to be exposed to contaminants and the piercing member itself.

Abstract: A semi-automated system suitable for use in a hospital setting for filling patient-specific liquid prescriptions to be administered by oral syringes on a just-in-time basis. The system enables hospital pharmacists to simplify and streamline their task, increasing the number of prescriptions that can be filled in a day, improving patient safety and care by minimizing medication errors and the consequences that ensue.

Abstract: A perforable closure for a container, is provided with at least a annular portion (2) fit to joint the container and connected to an end portion (3), perforable by means of a perforator (P) of an outflow or the like. At least the annular (2) and end (3) portions of said closure (1) are integral.

Abstract: Systems include one or more storage containers. A container may include one or more segments of a first ultra efficient insulation material shaped to define at least one substantially temperature-stabilized storage region, and an access region, including at least one region of the one or more segments of ultra efficient insulation material configured for at least one perforation by a perforation device, wherein one or more of the at least one perforation is configured to provide for a controlled egress of a discrete quantity of material from the at least one storage region.

Abstract: A method for obtaining the contents of a fluid-holding vessel having a cap secured to an open end thereof. The method includes penetrating a surface of the cap with a fluid transfer device and forming one or more air passageways between the penetrated surface of the cap and the fluid transfer device to allow air to be vented from the vessel. At least a portion of the contents of the vessel is then drawn into the fluid transfer device before the fluid transfer device is removed from the vessel.

Abstract: A cap including a penetrable material adapted to be pierced by a fluid transfer device and an absorbent material positioned above the penetrable material. The absorbent material permits passage of the fluid transfer device and absorbs fluid material present on an outer surface of the fluid transfer device as it is being removed from the cap. The cap is useful for accessing the contents of an associated fluid-holding vessel multiple times.

Abstract: A pressure-responsive container assembly and elastically-deformable penetrable cap is provided. Embodiments of the penetrable cap of the present invention include, but are not limited to: an annular sealing portion for engaging an inner surface of a container, a substantially rigid portion extending radially inward from the annular sealing portion; a flexible transition portion extending radially inward from the substantially rigid portion; and a penetrable portion extending radially inward from the transition portion for closing the opening defined by the container. Thus, embodiments of the present invention may thus allow the penetrable portion to elastically deform about the transition portion to a generally convex shape so as to exert a radially outward force that may be transmitted by the substantially rigid portion to the annular sealing portion so as to reinforce a fluid-tight seal between the annular sealing portion and the inner surface of the container.

Abstract: A bottle container in which sealing of the opening of a container body filled with a chemical liquid etc. and installation of a shoulder part, an unsealing member, and a cap can be made at the same time and that has a shoulder part fall-off prevention mechanism. A bottle container (1) has a container body (2) having a hollow cylindrical neck (21) whose upper part is open and having a step formed on a container body shoulder; a shoulder part (3) screwed on the outer peripheral surface of the neck (21) and having on its upper surface a hollow cylindrical body (32) that has a spout at its head; a cap (4) screwed on the outer peripheral surface of the hollow cylindrical body (32) and having a spout sealing means; and an unsealing prevention member (5) installed between the shoulder par (3) and the cap (4).

Abstract: A closure (12) for a container (14) adapted to store fluid (16) to be dispensed, said closure comprising a body (17) having an outer surface (23) communicating with the exterior of said container and an inner surface (27) embedded within said body wherein said outer surface includes a cavity (26) adapted to sealably receive a dispensing device (32).

Abstract: A multi-material, cryogenic, elastomeric closure is provided for sealing a container for samples of cryophilic biological materials, pharmaceuticals or the like. The closure includes at least one cryophilic elastomer having a glass transition temperature (Tg) below the cryogenic temperature to which the sample is to be subjected and at least one non-cryophilic elastomer having a Tg above the cryogenic temperature. The cryophilic and non-cryophilic elastomers are present in such a manner as to maintain a complete seal of the container opening at the cryogenic temperature.

Abstract: Septa or seals, sealing arrangements and methods of sealing containers are disclosed. The septa may be used for sealing containers containing medications or pharmaceuticals. The septa include a sheet of elastomeric material having a perimeter comprising at least one linear edge. Typically, the septa have a plurality of linear edges, for example, six, that provide a polygonal shaped seal, for example, a hexagonally shaped seal. The septa may be used in conjunction with plates having at least one linear edge, for example, hexagonally shaped plates. When mounted to a container with an appropriate cap, the linear edges of the septa and plates interact to minimize movement of the septa and enhance the sealing of the container.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.

Abstract: A device defining a chamber for receiving a substance and a thermoplastic portion in fluid communication with the chamber is provided along with a method of filling and sealing the substance within the chamber. The thermoplastic portion defines a penetrable region that is penetrable by a filling member and is heat resealable to hermetically seal an aperture therein by applying laser radiation at a predetermined wavelength and power. The thermoplastic portion comprises a thermoplastic body defining a predetermined wall thickness and includes a styrene block copolymer, an olefin and a predetermined amount of pigment allowing the body to absorb laser radiation at the predetermined wavelength, substantially prevent the passage of radiation through the predetermined wall thickness, and hermetically seal the aperture in the penetrable region in a predetermined time period.

Abstract: A container and method are provided for storing fat containing liquid products. The container includes a body defining a storage chamber for receiving the product, and a container closure. A first material portion forms at least most of the surface area overlying the storage chamber that can contact any product therein. Neither the body nor the first material portion leach more than a predetermined amount of leachables into the product or undesirably alter a taste profile thereof. A needle penetrable and thermally resealable second material portion either (i) overlies the first material portion and cannot contact any product within the storage chamber, or (ii) forms a substantially lesser surface area overlying the storage chamber that can contact any product therein in comparison to the first material portion. A sealing portion is engageable with the body to form a substantially dry hermetic seal between the container closure and body.

Abstract: A container unit for a drug is composed of a container, which is formed of a cylindrical drug-solution-containing portion and a drug-solution-filling neck portion, and a rubber closure for sealing the drug-solution-filling neck portion. The rubber closure comprises a disk-shaped head portion and a substantially cylindrical leg portion arranged on a lower wall of the head portion. The container is provided with a flat surface formed on a side of its inner wall at a boundary between the drug-solution-containing portion and the drug-solution-filling neck portion such that a lower end wall of the leg portion of the rubber closure can be brought into close contact with the flat surface, and at least a side wall of the drug-solution-containing portion forms a cornerless, rounded surface on a side where a drug solution is to be contained.

Abstract: A method for accessing the contents of a closed collection device having a cap and a fluid-holding vessel in fixed association. The method includes penetrating one or more materials of the cap with an air displacement pipette, thereby forming one or more passageways for venting air displaced from within the collection device, where the pipette includes structure for forming the one or more passageways. A fluid present in the vessel is drawn into the pipette before the pipette is removed from the collection device.

Abstract: A container, in particular a plastic ampule produced using a blow-molding process and filled and closed in the mold has a neck part (12) adjoining a container body (10) and threadly receiving a first cap part (14). A second cap part (16) extends at least partly between the first cap part (14) and the neck part (12) and is provided with an opening device (20). The opening device has at least one opening (22) for opening the container body (10), and can be closed by the first cap part (14). The first cap part (14) carries the second cap part (16) by the screwing-on process of the first cap part in such a way that the opening device (20) causes the container body (10) to be opened. A closure part (closure pin 26) of the first cap part (14) unblocks the opening (22) in the opening device (20) after the first cap part is unscrewed, with the second cap part (16) remaining on the neck part (12).

Abstract: A kit for preparing a cancer cell detection sample which is highly safe, simple, and high in precision, and can detect a cancer cell quantitatively, and a kit for cancer cell detection using the same, as well as a method for diagnosing cancer using those kits, and a method for preparing a sample for cancer cell detection are provided. A kit for preparing a detection sample for detecting a cancer cell of the present invention, comprising a test container having an opening for receiving a biological sample collected from a subject, and a reagent inclusion part for accommodating a reagent containing a virus, a seal part for sealing the reagent inclusion part of the test container, a cap for closing the opening, and an opener for breaking the seal part.

Abstract: The present invention provides a communication member for a medical container capable of allowing communication between the inside and the outside of a container body containing a liquid in a state of being fixed to the container body. The communication member includes: a valve 2 having an insertion hole 2a; a tubular body 3 supporting the valve 2; and a closing film 4 for closing a bore of the tubular body 3 in the bore and in the vicinity of the valve 2. The tubular body 3 and the closing film 4 are molded integrally. A groove 4a that passes through the center of the closing film 4 is formed on either a surface of the closing film 4 on the valve 2 side or a surface opposite to the valve side.

Abstract: The invention relates to a closure for a liquid container, comprising a plug manufactured from at least partially flexible material with a recess which is arranged at least substantially in axial direction in the plug and which is accessible on at least one side, and an operating member protruding outside the plug and displaceable in the recess such that a force exerted by the operating member on the recess in the plug can be modified by displacing the operating member. The invention also relates to methods for placing such a closure into a liquid container and removing thereof from a liquid container.

Abstract: A urine sample is taken by providing to the person a container having a removable cap with an initially unbroken elastomeric septum puncturable by a blunt tipped pipette and self-resealing following withdrawal of the pipette from the septum. The urine specimen is deposited in the container and the cap replaced. The container with the specimen is conveyed to a laboratory location for analysis where the septum is punctured by manually pressing the blunt tip of a plastic pipette against the septum with sufficient force to puncture through the septum and into the container with the tip. A sample of the urine specimen is drawn into the pipette and the pipette tip withdrawn to allow the septum to self-reseal, such that the urine specimen is sampled for analysis without reopening the container cap following replacement of the cap at the specimen collection site.

Abstract: A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retaining structure. The retaining structure is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retaining structure may be penetrable by a fluid transfer device.