Abstract: A device defining a chamber for receiving a substance and a thermoplastic portion in fluid communication with the chamber is provided along with a method of filling and sealing the substance within the chamber. The thermoplastic portion defines a penetrable region that is penetrable by a filling member and is heat resealable to hermetically seal an aperture therein by applying laser radiation at a predetermined wavelength and power. The thermoplastic portion comprises a thermoplastic body defining a predetermined wall thickness and includes a styrene block copolymer, an olefin and a predetermined amount of pigment allowing the body to absorb laser radiation at the predetermined wavelength, substantially prevent the passage of radiation through the predetermined wall thickness, and hermetically seal the aperture in the penetrable region in a predetermined time period.

Abstract: A method for obtaining the contents of a fluid-holding vessel having a cap secured to an open end thereof. The method includes penetrating a surface of the cap with a fluid transfer device and forming one or more air passageways between the penetrated surface of the cap and the fluid transfer device to allow air to be vented from the vessel. At least a portion of the contents of the vessel is then drawn into the fluid transfer device before the fluid transfer device is removed from the vessel.

Abstract: A vascular access device for communicating with the vascular system of a patient may include a status indicator. The status indicator may detect and signal that a period of time has elapsed in relation to the use of the vascular access device.

Abstract: The disclosed invention relates to a reaction bottle comprising a container with a container opening and a container interior, a septum associated with the container and configured to releasably seal the container opening, a needle holder associated with the container, the needle holder defining a holder cavity, a needle associated with the needle holder, the needle disposed at least partially within the holder cavity, wherein the septum is deformable between a sealing rest state and a punctured state, and the septum is deformable into puncturable impingement with an end of the needle when the septum is in the punctured state.

Abstract: A closure (2) for closing an opening of a container (1) for storing and removing sterile or moisture-sensitive media has a closure cap (3), which can be connected to the container in a fluid-tight manner, and a piercable, self-closing septum (20), which closes at least one removal opening (7) in the closure cap (3) in a fluid-tight manner, wherein the closure (2) has a rotatably mounted protective cap (4) with a cutout (5). The cutout (5) is arranged off-centre in the protective cap (4) and the closure cap (3) has off centre a closure region (9) which is not impinged by the at least one removal opening (7) and is larger than the cutout (5) in the protective cap (4). The closure (2) has a latching mechanism, which is suitable for arranging the protective cap (4) in relation to the closure cap (3) in such a way that the cutout (5) in the protective cap (4) is aligned either in line with the or a removal opening (7) in the closure cap (3) or at a distance from the removal opening or openings (7).

Abstract: A seal for a valve for use in a pharmaceutical dispensing device, which seal is formed from an elastomeric composition comprising: (a) an isobutylene polymer or co-polymer thereof; (b) a cross-linking agent for the isobutylene polymer or co-polymer thereof; and (c)) an accelerator for the cross-linking agent, wherein the accelerator includes a polysulphide compound derived from a substituted dithiocarbonic acid or derivative thereof.

Abstract: Disclosed is a uniquely configured medicament vial assembly which includes a storage vial, a stopper member and a securing ring. The vial assembly is configured to improve healthcare worker safety by providing a shielded gripping location to aid in the reduction of accidental needle sticks. The storage vial has a body portion which defines an interior chamber for storing a predetermined medicament and a neck portion through which medicament is received into and withdrawn from the interior chamber. The stopper member is inserted into the mouth of the vial and establishes a first seal. The securing ring is engaged with the mouth of the vial and adapted and configured for retaining the stopper member within the vial mouth and effectuating a second seal. The securing ring is formed from a thermoplastic and/or elastic material. Preferably, the securing ring is formed by molding the thermoplastic and/or elastic material over a portion of the storage vial and stopper member when engaged within the vial mouth.

Abstract: It is the object of the present invention to provide a sealed container which comprises a container comprising a thermoplastic resin and a stopper which is hardly slackening even when used in combination with the container, and a vacuum specimen-sampling container comprising the sealed container.

Abstract: A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retaining structure. The retaining structure is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retaining structure may be penetrable by a fluid transfer device.

Abstract: A perforable closure for a container, is provided with at least a annular portion (2) fit to joint the container and connected to an end portion (3), perforable by means of a perforator (P) of an outflow or the like. At least the annular (2) and end (3) portions of said closure (1) are integral.

Abstract: A cap assembly for a container that holds a perishable product. The cap assembly defines an opening through which the perishable product inside the container can be accessed. At least one obstruction plate is present within the cap assembly. Each obstruction plate is positionable between an open position, where the obstruction plate is clear of the opening, and a closed position where the obstruction plate obstructs the opening. A mechanism is provided within the cap assembly that automatically moves each obstruction plate from its open position to its closed position when the shelf life of the perishable product has expired. Optionally, the cap assembly may also include at least one condition sensor for detecting a condition harmful to the perishable product in the container. The mechanism also closes each obstruction plate if such a harmful condition is detected by the condition sensor.

Abstract: A hydraulic or other type of high-pressure hose fitting can be temporarily sealed using a special type of plug. The plug is made of a rubber like material and can be used both as a male plug or a female plug. The plug contains a plug body with a tapered end portion that can be pushed into and seal against the tapered seat of a female hydraulic fitting. The plug also contains an internal open ended bore that can be pushed over a male fitting with the threads of the male fitting tightly pressing into the rubber material to form a seal and minimize the plug being blown off the fitting.

Abstract: The disclosure is directed to a sealing assembly. The sealing assembly includes a cap having a top surface and a bottom surface, an adhesive layer adjacent the bottom surface of the cap, and a septum adjacent to the adhesive layer. The adhesive layer includes a self-bonding silicone composition and the septum includes at least one fluoropolymer layer. The disclosure is further directed to methods for making the aforementioned sealing assembly.

Abstract: According to the inventive method, a first element (22) of the assembly which is formed by the base (8) and the cap (22) of the device, is produced from a harder material than the second element (8) of said assembly (8, 22), the first element (22) is provided with at least one peripheral edge (30) for tightly penetrating an area facing the second element and the/each edge (30) of the first element (8) is/are covered with a lubricating agent which is suitable for forming a lubricating film (26) once the covering process is complete. Said film remains in place on the sealed edge(s), during the relative displacement of the cap (22) and the base (8), as well as when the cap (22) and base (8) are immobile in relation to each other. This film ensures that the cap can be fairly easily disassembled from the base.

Abstract: A connector for use in connecting a container of liquid nutrients to an enteral feeding tube to supply the liquid nutrients to a patient includes an integrally formed spike projecting into a cavity defined by an interior surface of a body of the connector. An air passage in communication with the cavity extends through the spike to outside the connector. A filter is secured to the end of the passage outside the connector. The body of the connector is free of structure that both defines any portion of the liquid passage and is formed for penetrating the puncturable seal of the container.

Abstract: A closure device (10) for a container (12) includes a filling device (14) that can be attached to an opening (16) of the container (12) A closure structure such as a membrane (18), a system (34), or a duckbill closure (54, 84) is attached to the filling device (14) in such a way that the opening (16) of the container (12) is sealed when the filling device (14) is attached to the opening (16). The closure structure is coated at least partially with polytetrafluoroethylene (22, 38, 60, 94) on one side (20, 40, 58, 90) that is accessible from outside the container (12) in the assembled state of the filling device (14) on the container (12).

Abstract: The present disclosure relates to a septum, e.g., for a sample container. A septum may comprise a first layer comprising a sheet of rubberized silicone compound and a second layer comprising a sheet of polytetrafluoroethylene. A second layer may be bonded to a first layer. The present disclosure also relates, in some embodiments, to a septum assembly. A septum assembly may comprise, for example, a septum and a cap. A cap may have an aperture (e.g., to permit insertion and/removal of a sampling device) A septum may be fitted into a cap such that the second layer is adjacent to the aperture. In some embodiments, the present disclosure further relates to a storage assembly. A storage assembly may comprise, for example, a septum assembly and vessel configured and arranged to contain a sample therein. A vessel may be capped by the septum assembly.

Abstract: A device and method are provided for needle penetrating and filling a chamber with a predetermined substance, and laser resealing a resulting needle hole in the device. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation at a predetermined wavelength and power thereto. The needle penetrable and laser resealable portion defines a predetermined wall thickness in an axial direction thereof, and includes a thermoplastic that substantially prevents the formation of particles released into the chamber from the needle penetrable and laser resealable portion during penetration by and withdrawal of the needle.

Abstract: A pharmaceutical closure is made from rubber or thermoplastic elastomer and has an amount of TiO2 present in the closure. The closure has a marking made by laser thereon. A method for manufacturing the closure consists of producing a rubber sheet, forming a plurality of closures on the rubber sheet, with the closures remaining integrally connected with each other through remaining sheet parts, marking each of the closures with a laser marking, and separating the closures from each other by punching.

Abstract: A container comprising a container body defining a storage chamber for receiving a substance and a container closure removably attached to the container body for sealing the storage chamber. The container closure includes a base defining an aperture in fluid communication with the storage chamber, and a needle penetrable and thermally resealable stopper overlying the aperture for aseptically filling the storage chamber with the substance and sealing the substance within the storage chamber with respect to the ambient atmosphere. A sealing portion engages the container body prior to filling and forms a substantially dry hermetic seal between the container closure and container body. The container further comprises an over closure engageable with the container closure such that removal or movement of the over closure from a first position to a second position results in substantially simultaneous removal of the container closure and stopper to allow dispensing of the substance.

Abstract: A closure system for a vial comprising: an elastic closure part to engage the mouth opening, a clamp part to hold the closure part in a closing relationship with the mouth opening, the clamp part defining an upper aperture through which a region of the upper surface of the closure part is exposed when the clamp part is engaged with the vial, a cover part to engage the clamp part to cover the exposed region, the cover part engaging with the closure part to provide two or more concentric ring-shaped seals, at least part of the cover part being removable from the vial to allow access to the closure.

Abstract: A cap and bottle device is provided that includes a cap, a septum, and a container that individually and collectively improves the capacity of the assembly to securely contain substances. The cap includes internal threads that mate external threads of the container containing the substance. The cap further includes flexible teeth for engaging rigid lugs that are molded into the finish on the neck of the container. The septum sealably fits between the cap and within an opening of the container to provide barrier between the contained substance and the surrounding environment.

Abstract: A reaction bottle comprising: a container, with a container top and a container interior; a bottle cap removeably attachable to the container top, the bottle cap having a cap top and a cap cavity; a septa attached to the bottle cap and configured to releasably seal the container when the bottle cap is attached to the container top; a needle holder attached to the cap top; a hollow needle attached to the needle holder and located in the cap cavity; a needle conduit in fluid communication with the hollow needle; wherein the septa is configured to deform from an at rest state into a punctured state when pressure within the container interior reaches a first threshold value and the septa deforms into the cavity and is punctured by the hollow needle, and the septa is further configured to return to the at rest state when the pressure within the container reaches a second threshold value and the septa reseals upon being no longer punctured by the hollow needle.

Abstract: Device (24) for transferring a fluid (22) to and/or from a fluid container (12) having a sealing member (14). The device (24) comprises a piercing member (16) for penetrating the sealing member (14) and an elongated body defining a longitudinal flow channel (18) through which a fluid (22) may flow into and/or out of the fluid container (12) and at least one opening (20) that communicates with the flow channel (18). Said at least one opening (20) is arranged to extend along at least 1% of the length (l) of the piercing member (16) to ensure that at least part of said at least one opening (20) is located substantially adjacent to the innermost side (14b) of a sealing member (14) when the device is in use.

Abstract: A system includes a cap having an opening, and a septum configured to engage with the cap. The septum includes a first portion having a first width, and a second portion having a second width smaller than the first width. The second portion is sized and shaped to be received by the opening of the cap.

Abstract: The invention relates to a closing cap for containers that are filled with medical liquids. The closing cap includes removal and injection sites. The removal site has a first opening for removing the medical liquid and is obturated by a first pierceable self-sealing membrane. The injection site includes a second opening for injecting an additive and is obturated by a second pierceable self-sealing membrane. The first and second membranes are configured differently.

Abstract: A device defining a chamber for receiving a substance and a thermoplastic portion in fluid communication with the chamber is provided along with a method of filling and sealing the substance within the chamber. The thermoplastic portion defines a penetrable region that is penetrable by a filling member and is heat resealable to hermetically seal an aperture therein by applying laser radiation at a predetermined wavelength and power. The thermoplastic portion comprises a thermoplastic body defining a predetermined wall thickness and includes a styrene block copolymer, an olefin and a predetermined amount of pigment allowing the body to absorb laser radiation at the predetermined wavelength, substantially prevent the passage of radiation through the predetermined wall thickness, and hermetically seal the aperture in the penetrable region in a predetermined time period.

Abstract: A port closure system for use with a fluid container having fluid ports includes administrative and additive port closure assemblies. The administrative assembly receives a piercing pin and includes an administrative housing which seals closed one fluid port. A sleeve extends from an interior surface past a base surface in the administrative housing. The sleeve has an upper portion and a lower portion, of differing diameters. A cap assembly mates with the administrative housing, sealing the interior surface of the administrative housing. A removable cap provides access to the interior surface. The additive assembly receives a needle and includes a reseal housing which seals closed another fluid port. Another cap assembly mates with the reseal housing, sealing an interior face of the reseal housing. Another removable cap provides access to the interior face. A reseal element is mechanically retained between the reseal housing and cap assembly.

Abstract: A hermetically sealed thermoplastic container is equipped with a unitary closure that includes a draining spike access aperture occluded by a removable, twist-off cap and an internal draining spike stabilizer situated in the neck portion of the container.

Abstract: A seal member for a bulk liquid dispensing cartridge includes a flat circular seal disk, a frustoconical wall extending away and outwardly from an intermediate portion of the seal disk, and a ring positioned at an open end of the frustoconical wall. The seal member may be assembled with a cap. The cap has an end wall and a depending cylindrical skirt wall. The skirt wall has an internal diameter and the seal member ring has an outer diameter slightly less than the skirt wall internal diameter. The ring abuts an interior surface of the cap end wall. The cap has a central opening through the end wall with a diameter no larger than an inner diameter of the ring. The dispensing cartridge has a cylindrical mouth wall with inner and outer diameters. The cap skirt wall has an internal diameter sized to receive the mouth wall outer diameter and the diameter of the seal disk is larger than the mouth wall inner diameter.

Abstract: Storage containers for storing fluids are generally discussed herein with particular discussions on storage containers having a rubber septum for port access. Aspects of the present invention further include provisions for a gasket to displace an internal space between a cap and a nozzle of a storage container to minimize or eliminate seepage into the same space.

Abstract: A pierceable cap may be used for containing sample specimens during storage and transport. The pierceable cap may prevent unwanted escape of sample specimen before transfer with a transfer device. The pierceable cap may fit over a vessel. An access port in the pierceable cap may allow passage of a tip of a transfer device though the pierceable cap. A frangible layer may be disposed across the access port. One or more extensions proximate to the frangible layer may be coupled to the pierceable cap by coupling regions or other similar devices. The one or more extension may rotate around the one or more coupling regions during insertion of the transfer device. The movement of the one or more extensions may pierce the frangible layer to create airways and allow air to escape from a vessel at a reduced velocity.

Abstract: A molding die assembly includes an upper die and a lower die, wherein at least one of the upper and lower dies is provided with a cavity corresponding to the shape of a rubber member to be molded, wherein at least one of the upper and lower dies is provided with an annular projection around a cavity. The distance between the upper and lower dies at the annular projection is made smaller than the distance between the opposed surface portions, other than the cavity, of the upper and lower dies. A rubber member produced by the above mentioned molding die assembly is also provided.

Abstract: A plug insertion device for inserting a plug into a container. The device includes sides defining an opening therebetween. The opening receives a plurality of containers having openings at the upper end thereof. A platen having a plurality of insertion pins is pivoted over the sides. A sheet of plugs is positioned over the openings in the containers. The insertion pins engage the plugs and insert them into the containers upon application of a force to the platen. A return spring returns the insertion pins to their retracted position allowing for the removal of the plugged containers.

Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic such as a halogenated ether compound in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered to the subject to anesthetize the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, xenon, and mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.

Abstract: A plastic cap having multiple wedge-shaped sections that are structurally interrelated to a closed side wall and adapted to be moveably engaged by a fluid transfer device penetrating the cap. A seal fixed to the cap covers the wedge-shaped sections.

Abstract: A stopper for flasks for pharmaceutical products, characterized in that it comprises, in combination: a plug with resilient means for adjustment to the inner face of the neck and of the mouth of the container and an upper stoppering wall; means for defining a position for pre-stoppering of the flask, before the stoppered position; a protector joined to the plug which comprises a lateral wall of synthetic material, said lateral wall having a projection for engagement with an annular protuberance located on the mouth of the container; the aforesaid protector having an extension which, when the stopper is in its pre-stoppered position, creates a labyrinth closure with respect to the particles which might be present in the surroundings in which the container is being handled.

Abstract: A collection device comprising an open-ended vessel for receiving and holding a fluid substance and a cap configured to position a specimen retrieval device along an inner surface of the vessel when the cap is fixedly associated the vessel.

Abstract: A two-piece seal vial assembly. The first piece is a vial defining an aperture adapted to contain a liquid. The vial has a base, a crown disposed opposite the base, and an upright side wall extending from the base to the crown and including a tapered inner diameter and a flange located proximate the crown. The second piece is a seal top defining an opening that runs through the length of the seal top. The seal top has a top portion providing a neck finish and, when the seal top and the vial are assembled, a snap groove releasably receiving the flange of the vial and a tapered portion that frictionally engages the tapered inner diameter of the vial. Although not one of the two main components of the assembly, a cap may be included to releasably engage the neck finish of the seal top to close the seal top.

Abstract: A method of fusing a component to a sterilized storage or delivery device formed of a cyclic olefin polymer which includes forming the storage or delivery device from a cyclic olefin polymer, forming a second member or component having at least a surface layer formed of the second polymer, wherein the Hansen relative energy distance Ra/Ro of the second polymer relative to the cyclic olefin polymer is equal to or less than 0.7, applying the second member to the storage or delivery device, and heating the assembly to the sterilization temperature, thereby causing the second polymer to chemically interact with the cyclic olefin polymer, fusing the second component to the storage or delivery device. The preferred embodiment of the invention is a medical container, such as a vial, wherein the vial is formed of a cyclic olefin polymer and the cap, closure or collar is formed of a second polymer heat fused to the vial or container.

Abstract: A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the cap has a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retainer. The retainer is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retainer may be penetrable by a fluid transfer device.

Abstract: A method for obtaining the contents of a fluid-holding vessel having a cap secured to an open end thereof. The method includes penetrating a surface of the cap with a fluid transfer device and forming one or more air passageways between the penetrated surface of the cap and the fluid transfer device to allow air to be vented from the vessel. At least a portion of the contents of the vessel is then drawn into the fluid transfer device before the fluid transfer device is removed from the vessel.

Abstract: A device and method are provided for needle penetrating and filling a chamber with a predetermined substance, and laser resealing a resulting needle hole in the device. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation at a predetermined wavelength and power thereto. The needle penetrable and laser resealable portion defines a predetermined wall thickness in an axial direction thereof, and includes a thermoplastic that substantially prevents the formation of particles released into the chamber from the needle penetrable and laser resealable portion during penetration by and withdrawal of the needle.

Abstract: A method of fusing a component to a sterilized storage or delivery device formed of a cyclic olefin polymer which includes forming the storage or delivery device from a cyclic olefin polymer, forming a second member or component having at least a surface layer formed of the second polymer, wherein the Hansen relative energy distance Ra/Ro of the second polymer relative to the cyclic olefin polymer is equal to or less than 0.7, applying the second member to the storage or delivery device, and heating the assembly to the sterilization temperature, thereby causing the second polymer to chemically interact with the cyclic olefin polymer, fusing the second component to the storage or delivery device. The preferred embodiment of the invention is a medical container, such as a vial, wherein the vial is formed of a cyclic olefin polymer and the cap, closure or collar is formed of a second polymer heat fused to the vial or container.

Abstract: Protected stopper for test-tubes, including a substantially cylindrically extending elastomer inner body arrangeable to close a test-tube including a sealing portion formed to be inserted inside the mouth of the test-tube and a collar piece connected above the sealing portion and projecting radially with respect to the latter to receive, in bearing contact therewith, the mouth of said test-tube. The stopper includes a substantially cylindrical cover, closed at the top and mounted to cover the inner body. An engaging mechanism for simultaneously securing the inner body to the cover and the stopper to the test-tube are included, consisting of a plurality of projections extending on the inside of the side wall of the cover, coming into contact with the outer wall of the test-tube and spaced from the closing wall of the cover to form a contact step capable of constraining the projecting collar piece of the inner body.

Abstract: A separating mechanism for inserting in a receptacle chamber of a container receptacle having a longitudinal axis comprises two adjacently disposed components and a sealing device which is directed towards an internal wall of the container receptacle. The components have two ends spaced apart from one another in the direction of the longitudinal axis, and a flow passage extends therebetween. The components can be applied against the internal wall by at least one pressing element and, in an initial position, the flow passage is established between the adjacently disposed components spaced apart from one another by the pressing element.

Abstract: A plug body for chemical container capable of preventing the contact thereof with chemical and preventing ruptured film from falling into the chemical, comprising a valve (1) having an insert hole (3) formed at the center thereof, a cover (2) for holding the valve (1) by covering at least the upper peripheral edge of the valve (1), and a locking means for locking an insert body to the cover (2) by using the edge part of the cover (2) having a fitting hole formed therein when the insert body is inserted into the insert hole (3), wherein the rear surface peripheral part of the valve (1) is held by a pedestal part (5), and a film (4) covering the rear surface of the valve is disposed on the upper surface of the pedestal part (5).

Abstract: A pressure-sealing, pressure-monitoring closure for non-invasively sealing a reaction vessel to a defined release pressure in microwave-assisted chemistry is disclosed. The closure includes a pressure-resistant, microwave-transparent reaction vessel, one portion of which defines a mouth, a flexible pressure-transmitting releasable cover assembly on the mouth of the vessel, a pressure transducer on the cover and external to the vessel for monitoring the pressure in the vessel as exerted against the flexible cover, and a clamp for urging the vessel, the cover and the transducer together under a defined force so that when the pressure in the vessel exceeds the defined force, the cover can flex and release the pressure from the vessel.

Abstract: A closure means adapted to fit into the neck or mouth of a container, said closure means comprising a plug of resilient material said plug incorporating a slit which extends through the body of the plug characterized that, in a resting configuration and prior to insertion of the closure means into a container, the breadth of the slit is non-uniform along the length of the slit.

Abstract: Disclosed is a uniquely configured medicament vial assembly which includes a storage vial, a stopper member and a securing ring. The vial assembly is configured to improve healthcare worker safety by providing a shielded gripping location to aid in the reduction of accidental needle sticks. The storage vial has a body portion which defines an interior chamber for storing a predetermined medicament and a neck portion through which medicament is received into and withdrawn from the interior chamber. The stopper member is inserted into the mouth of the vial and establishes a first seal. The securing ring is engaged with the mouth of the vial and adapted and configured for retaining the stopper member within the vial mouth and effectuating a second seal. The securing ring is formed from a thermoplastic and/or elastic material. Preferably, the securing ring is formed by molding the thermoplastic and/or elastic material over a portion of the storage vial and stopper member when engaged within the vial mouth.