Self-sealing, Piercable-type Closure Patents (Class 215/247)
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Patent number: 4444330Abstract: A stopper for hermetically sealing the opening of a medical container is made of an injection-moldable polymeric material containing a blend of 30 to 90% by weight of a butyl-based rubber and 70 to 10% by weight of a thermoplastic elastomer.Type: GrantFiled: July 27, 1982Date of Patent: April 24, 1984Assignee: Terumo Kabushiki KaishaInventors: Masaaki Kasai, Toshiji Ichikawa
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Patent number: 4441621Abstract: A pierceable closure member for use on a vacuum-filled vial, including a rubber plug having an annular leg and an annular protrusion, and a lamina having an annular recess and secured to the rubber plug with the annular recess receiving therein the annular leg. For the purpose of retaining the vacuum inside the vial, the annular protrusion on the rubber plug has a specific dimensional relationship to the other parameter of the closure member.Type: GrantFiled: August 16, 1982Date of Patent: April 10, 1984Assignees: Takeda Chemical Industries, Ltd., Daikyo Gomu Seiko, Ltd.Inventors: Yoshiharu Matukura, Denpei Sudo
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Patent number: 4441538Abstract: A container for liquids, preferably sterile liquids comprises a hollow body constructed of plastic material having a plurality of tubular ports integrally formed and extending therefrom. Each port has a quantity of plastic material integrally formed as a diaphragm within the port so as to seal the container. In a preferred embodiment, at least one of the ports has a resealable septum sealed within it. The diaphragm is positioned between the septum and the liquid within the container so as to prevent deterioration of the resealable septum caused by exposure to the liquid. Both the resealable septum and the diaphragm are constructed of a material which is penetrable by a hypodermic needle for use in administering sterile solutions.Type: GrantFiled: September 3, 1981Date of Patent: April 10, 1984Assignee: Abbott LaboratoriesInventors: Mark E. Larkin, Leonard J. Meyer
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Patent number: 4437574Abstract: A plastic closure or cap of the tamper indicating type for sealing a container has collar means that frictionally grasp the rim of the container and an outer collar part which has a latch cooperating with a catch on the rim. The cap has a pull tab which facilitates tearing the collar part from the rim to separate the latch from the catch. The cap also has a material receiving opening having an irremovable closure plug. The plug may be carried by a tongue attached to the cap or it may be independent of the cap. The material receiving opening may have a lower end portion closed by a wall that may be penetrated by a hollow needle to fill the container.Type: GrantFiled: October 14, 1981Date of Patent: March 20, 1984Inventor: William Ruklic
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Patent number: 4429803Abstract: It is difficult to detect whether the rubber seal on a vial or on a hypodermic syringe cartridge has been penetrated, because the rubber seal over the mouth of the container is purposely soft and self-sealing to prevent contamination of the fluid within the container. As a result pilfering of narcotics from such containers has gone largely undetected. To remedy this situation, a blister-like sac of a plastic film and containing a harmless dye is mounted within the mouth of the container between the rubber seal and the contents of the container. It is impossible for a hypodermic needle to be inserted through the seal and into the fluid within the container without puncturing the blister-like sac and thereby releasing the harmless dye into the fluid within the container. Thus, if the seal has been broken, the fluid in the container will be tinted with the color of the harmless dye.Type: GrantFiled: March 31, 1982Date of Patent: February 7, 1984Assignee: Butterfield GroupInventor: Ida M. Butterfield
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Patent number: 4418827Abstract: A visually conspicuous object shaped like a disc or plug is mounted at the mouth of a container or in the neck of the container where it is held only by friction or some other easily-overcome force. The object is impenetrable by a hypodermic needle. When such a needle is thrust through the diaphragm-like seal of the container, the needle strikes the object, and overcomes the friction by which the object was retained in the mouth of the container, thereby releasing the object which then falls or migrates into the body of the container to serve as a visual indicator that the seal has been punctured.Type: GrantFiled: March 31, 1982Date of Patent: December 6, 1983Assignee: Butterfield GroupInventor: Ida M. Butterfield
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Patent number: 4416661Abstract: Injection site device comprising an elastomeric plug closing a fluid entry port and held in a compression fit by means of an open overcap bonded to the outer surfaces of the entry port.Type: GrantFiled: December 24, 1981Date of Patent: November 22, 1983Assignee: Cutter Laboratories, Inc.Inventors: Melvin H. Norman, Reinhold R. Manske, Neil J. Sheehan
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Patent number: 4412623Abstract: A teat feeding bottle comprises a container (1) having a neck portion (11) which includes external threads (12) and a pierceable wall (13). A screw cap (5) is provided with internal threads (53) and a flange (52) which sealingly clamps a flange (42) of the teat. A spike (3) accommodated completely within said teat and having a pointed tip (31) on its one end and a pushbutton-like enlargement (32) on its other end, is guided within an opening (22) of a longitudinal guiding portion (2). The longitudinal guiding portion (2) extends partially into the interior of the teat (4) and has a flange (21) thereof fixed by the screw cap (5). The spike (3) has a longitudinally (axially) extending groove (33) which, in combination with the wall of opening (22) opposing this groove, defines a passage for liquid dispensed from the container (1) when the spike has penetrated the pierceable wall (13). Upon penetration of this wall, the spike remains within the interior of the teat or of the container (1), respectively.Type: GrantFiled: December 28, 1981Date of Patent: November 1, 1983Inventor: Manfred Schmidt
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Patent number: 4412573Abstract: An improved injection site (18) for a medical fluid container (10) is provided, along with a procedure facilitating the automated assembly of the injection site (18). An oversized, compressible situs (22) is retained in compressive relation to a generally tubular port (20) in a manner which makes inadvertent removal of the situs (22) virtually impossible.Type: GrantFiled: December 28, 1981Date of Patent: November 1, 1983Assignee: Baxter Travenol Laboratories, Inc.Inventor: Brian D. Zdeb
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Patent number: 4366912Abstract: A rubber closure device for closing the mouth of a vial or like vessel comprises an inner closure member having a leg portion adapted to tightly protrude into the mouth, and an overlay closure member overlaying the inner closure member. The inner closure member is made of fluorinated rubber and has a thickness sufficient to exhibit a resistance to chemicals.Type: GrantFiled: February 25, 1981Date of Patent: January 4, 1983Assignee: Takeda Chemical Industries, Ltd.Inventors: Yoshiharu Matukura, Tokio Kataoka, Hiroshi Fujisawa
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Patent number: 4364903Abstract: An arrangement of separation device is provided such that after centrifugation, for example, the heavy materials at the bottom of the separation container may be directly removed from the bottom without first having to decant or otherwise remove the lighter fraction at the upper end of the container. The arrangement may include, for example, a conventional tube-type container modified to have an opening in the bottom. A specially configured plug or stopper is utilized in combination with the container bottom opening to seal the opening closed, which plug is configured to complete the bottom end of the container and to provide an access septum for needle penetration in the bottom of the container. The arrangement of the plug prevents displacement thereof, once it is properly positioned, and includes specifically, a locking detent to prevent the plug from being displaced inwardly upon insertion of a needle into the plug.Type: GrantFiled: April 2, 1981Date of Patent: December 21, 1982Assignee: Becton, Dickinson and CompanyInventor: Gilbert S. Bittings
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Patent number: 4364485Abstract: A pilfer-proof container for injectable fluid. An inner seal having an opening is fixedly secured to the neck of a bottle to hold a stopper. An outer seal covers the opening and is removably attached to the inner seal with non-flaking, non-rebondable adhesive.The sealing system allows inspection of the stopper after the inner seal has been attached.Type: GrantFiled: May 15, 1981Date of Patent: December 21, 1982Assignee: Schering CorporationInventor: Julius Z. Knapp
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Patent number: 4362698Abstract: Closures for fluid sample cups, preferably for blood, according to the teachings of the present invention are preferably formed in a multilayered sheet including a matrix of closures and remaining area located around and between the closures. Specifically, the multilayered sheet includes two sided adhesive tape sandwiched between a layer of adhesive covering paper and a rigidifying layer. An elastic layer is adhesively secured to the rigidifying layer. A matrix of first apertures extend through the tape, the paper layer, and the rigidifying layer, with the material located inside of the first apertures being discarded. A matrix of second apertures extend through the tape and the elastic and rigidifying layers concentric with and of greater radius than the first apertures and which define the matrix of the closures. A matrix of slits are also formed in the elastic layer within the first apertures.Type: GrantFiled: March 7, 1980Date of Patent: December 7, 1982Assignee: Sherman-Boosalis CorporationInventors: Nicholas T. Boosalis, George E. Sherman
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Patent number: 4362250Abstract: A container having a dual-neck configuration providing inner and outer seals for reactive or volatile materials stored therein. An inner cylindrical neck provides the inner seal, and is surrounded by an outer neck providing the outer seal. Inner and outer caps are threaded onto the respective inner and outer necks, and each cap is provided with an elastomeric liner. The inner cap is further provided with an axial bore to allow a hollow needle to pass therethrough, thereby enabling material within the container to be withdrawn through the needle, and the inner elastomeric seal reseals itself after withdrawal of the needle.Type: GrantFiled: March 26, 1981Date of Patent: December 7, 1982Assignee: National Distillers & Chemical Corp.Inventor: Auburn B. Cottingham
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Patent number: 4358425Abstract: A transparent tube for use in the cavity of the rotor of a high speed centrifuge. The tube is penetrable at its bottom end by a needle of a hypodermic syringe. The tube is open at the top and has a rounded bottom with an opening forming a passageway therein. A recess forming a shoulder co-axial with the passageway is provided both on the inner side and the outer side of the tube. A resilient plug having flanges at each end provides a tight fitting closure for the passageway and recesses.Type: GrantFiled: February 17, 1981Date of Patent: November 9, 1982Assignee: Beckman Instruments, Inc.Inventors: Jack P. Finney, Kenzo Ishimaru
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Patent number: 4340148Abstract: A luer cap for use on ports of medical devices such as cardiotomy reservoirs and blood sets. The cap comprises an outer wall (10) having a generally circular cross-sectional shape. An inner wall (12) and end wall (20) define an internal port receiving cavity (13). The inner wall (12) is threaded to mate with threads or a flange on a female luer port. The mating surfaces of the luer cap and the luer port can be sterilized through a hollow tubular portion (18), end wall (20), and outer wall (10) of the luer cap.Type: GrantFiled: October 14, 1980Date of Patent: July 20, 1982Assignee: Baxter Travenol Laboratories, Inc.Inventor: David S. Beckham
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Patent number: 4331254Abstract: A seal for an opening through which an object (e.g. hose pipe) extends which comprises a stack of flexible sheets (1, 2, 3 and 4) one on top of each other, each of at least two adjoining sheets (1, 2) having an aperture therein of dimensions smaller than those of the cross-section of that part of the object contacting the seal and a series of slits radiating from said aperture towards the perimeter of the sheet and each of at least two other adjoining sheets (3, 4) having a series of slits radiating towards the perimeter of the sheet from the center of the sheet, the series of slits in at least two adjacent sheets being offset with respect to each other.Type: GrantFiled: September 8, 1980Date of Patent: May 25, 1982Assignee: Butterworth Systems Inc.Inventor: John Haggerty
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Patent number: 4325368Abstract: An infusion device for medical purposes is described, comprising a container (10) with at least two chambers (14, 16), with their openings (20, 22) closable by means of sealing stoppers, in particular by a common stopper (12). The sealing stopper has a cavity (34) in the area of the opening (20) of the first chamber (14) which communicates with the second chamber (16). A cannula (42) may be pierced through the stopper (12) in the area of the opening (20) of the first chamber (14) and can simultaneously receive infusional solutions from the two chambers through two orifices (44, 46) spaced longitudinally from one another. The connection between the cavity (34, 40) in the stopper (12) may be established in one embodiment by means of a connecting cannula (56) with orifices (58, 60).Type: GrantFiled: December 14, 1979Date of Patent: April 20, 1982Assignee: Ingrid BernardInventor: Erich Kaemmerer
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Patent number: 4307766Abstract: A plastic container for medical liquid has an improved mouth portion for the admission or withdrawal of a medical liquid. The mouth portion is characterized by comprising (i) a rigid plastic cylindrical body, one end of which communicates with the inside of the container and the other end of which is enlarged in diameter; (ii) a rubber stopper body inserted in the enlarged end of the mouth portion; (iii) an annular rigid plastic stopper holding member which is attached to the upper edge of the enlarged end of the mouth portion and whose inner peripheral portion presses the upper surface of the peripheral portion of the rubber stopper body; and (iv) a water-impermeable soft sealing member interposed between the bottom of the rubber stopper body and the bottom of the enlarged end of the mouth portion.Type: GrantFiled: May 14, 1980Date of Patent: December 29, 1981Assignee: Terumo CorporationInventor: Nobukazu Tanokura
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Patent number: 4303067Abstract: A flexible bag for dispensing medical liquid, such as intravenous solutions, to a patient. The bag has an improved additive port for periodically injecting medication or other liquid into the bag through a puncturable, resealable plug. The additive port includes a flexible support tube segment sealed between opposed walls of the bag and a substantially stiffer puncture tube sealed to an outer end of a port tube segment, which substantially stiffer puncture tube is in turn sealed to a tear-off closure. A puncturable, resealable plug is held against an integral puncturable (nonresealable) diaphragm of the puncture tube by the retaining member sealed within the puncture tube. This construction provides more reliable, leak proof sealing between components of an additive port of a medical liquid bag.Type: GrantFiled: January 21, 1980Date of Patent: December 1, 1981Assignee: American Hospital Supply CorporationInventors: Terry Connolly, Milton L. Patrick, Thomas E. Rudolph, Alan Stanley
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Patent number: 4301590Abstract: A unitary molded injection site comprising a central, needle-receiving portion and a skirt portion may be assembled onto a support tube by temporarily convoluting the skirt portion about the central portion to expose its inner surface; bringing the end of the support tube adjacent to the inner surface; and bringing the skirt portion back toward its original, unstressed configuration, to surround the end portion of the tube in telescoping relation. An advantage of this is that the injection site is positioned on the support tube in relatively unstressed condition. Furthermore, the skirt portion may define on its inner surface a plurality of sealing rings adapted to sealingly bear against the support tube.Type: GrantFiled: November 15, 1979Date of Patent: November 24, 1981Assignee: Baxter Travenol Laboratories, Inc.Inventor: Gary A. Ward
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Patent number: 4301936Abstract: The disclosure is of a novel closure for air evacuated tubular container and comprises a tubular body having flexible, elastic sidewalls, an open end, a closed end formed by a cannula-pierceable, flexible, elastic end wall having a concavo-convex configuration in cross-section and a flange disposed radially about the periphery of the open end. The novel closure structure takes advantage of the vacuum force in the container to maintain a gas-proof, hermetic seal, reduces the thickness required of the closure to maintain the hermetic seal and is easier to assemble in an air evacuated container. The disclosure is also of a novel method of assembling the closure of the invention in an air evacuated tubular container.Type: GrantFiled: May 8, 1980Date of Patent: November 24, 1981Assignee: Becton, Dickinson and CompanyInventor: Edward P. Percarpio
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Patent number: 4295572Abstract: The disclosure is of a novel closure for air evacuated tubular containers and comprises a tubular body having flexible, elastic sidewalls, an open end, a closed end formed by a cannula-pierceable, flexible, elastic end wall having a concave-convex configuration in cross-section and a flange disposed radially about the periphery of the open end. The novel closure structure takes advantage of the vacuum force in the container to maintain a gas-proof, hermetic seal, reduces the thickness required of the closure to maintain the hermetic seal and is easier to assemble in an air evacuated container. The disclosure is also of a novel method of assembling the closure of the invention in an air evacuated tubular container.Type: GrantFiled: May 8, 1980Date of Patent: October 20, 1981Assignee: Becton, Dickinson and CompanyInventor: Edward P. Percarpio
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Patent number: 4294249Abstract: An injection site is disclosed comprising a self-sealing, puncturable member of resilient material and a housing wherein the puncturable member is compressibly confined by a swage-molded edge on the top of the housing. The injection site may be attached to an injection-receiving receptacle such as a medicament injection device as used in an assembly for intravenous administration.Type: GrantFiled: October 18, 1979Date of Patent: October 13, 1981Assignee: Cutter Laboratories, Inc.Inventors: Neil J. Sheehan, Melvin H. Norman
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Patent number: 4293078Abstract: A readily penetrable vacuum indicator closure for sealing an open end of an air evacuated blood collection tube. The closure comprises a flexible tubular body with an open first end and a closed second end formed by a penetrable, flexible end wall, with the end wall having an inner surface and an outer surface. When pressure on the inner and outer surfaces is substantially equal, the outer surface is convexly curved and the inner surface is concavely curved. This end wall is sufficiently flexible to deflect under the influence of a pressure differential on the end wall, such as may be perceived when the closure seals an evacuated blood collection tube. The outer surface of the flexible end wall is readily visible, thus serving as an indicator of relative pressures on opposite sides thereof. A flange is annularly disposed about the periphery of the tubular body adjacent to the second end.Type: GrantFiled: November 1, 1979Date of Patent: October 6, 1981Assignee: Becton, Dickinson and CompanyInventors: Edward P. Percarpio, William J. Holderith
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Patent number: 4290534Abstract: The disclosure is of a novel closure for air evacuated tubular containers and comprises a tubular body having flexible, elastic sidewalls, an open end, a closed end formed by a cannula-pierceable, flexible, elastic end wall having a concavo-convex configuration in cross-section and a flange disposed radially about the periphery of the open end. The novel closure structure takes advantage of the vacuum force in the container to maintain a gas-proof, hermetic seal, reduces the thickness required of the closure to maintain the hermetic seal and is easier to assemble in an air evacuated container. The disclosure is also of a novel method of assembling the closure of the invention in an air evacuated tubular container.Type: GrantFiled: May 8, 1980Date of Patent: September 22, 1981Assignee: Becton, Dickinson and CompanyInventor: Edward P. Percarpio
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Patent number: 4279352Abstract: A unitary molded injection site comprising a central, needle-receiving portion and a skirt portion may be assembled onto a support tube by temporarily convoluting the skirt portion about the central portion to expose its inner surface; bringing the end of the support tube adjacent to the inner surface; and bringing the skirt portion back toward its original, unstressed configuration, to surround the end portion of the tube in telescoping relation. An advantage of this is that the injection site is positioned on the support tube in relatively unstressed condition. Furthermore, the skirt portion may define on its inner surface a plurality of sealing rings adapted to sealingly bear against the support tube.Type: GrantFiled: March 13, 1980Date of Patent: July 21, 1981Assignee: Baxter Travenol Laboratories, Inc.Inventor: Gary A. Ward
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Patent number: 4266687Abstract: A laminated self-destructing sealing cover (10) has a container cover area (14) and pull tab (16). Protrusions (18) extend from the outer edge of the cover area (14) to promote proper use of the cover (10). A slit (20) may be into the protrusion (18) or the outer edge of the cover area (14) to promote tearing of the cover upon removal of a container. The bottom side of the cover (10) engaging the container top is a central disk (24) surrounded by an annular ring of adhesive material (28). Adhesive material (28) is self destructed upon removal of the cover (10) from the container to leave a telltale ring (28A) on the container top. In an alternate embodiment, an area of perforations (60) may be made in the area of the cover (10) for engaging the container top to leave a telltale trace of the cover on a container top upon removal of the cover (10).Type: GrantFiled: February 29, 1980Date of Patent: May 12, 1981Assignee: U.S. Clinical Products, Inc.Inventor: Robert Cummings
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Patent number: 4265242Abstract: A filter device for injectable fluids which includes a container in the open end of the device subdivided into a pair of sealed compartments with self sealing members in each compartment communicating the compartments with the interior of the vial, with the self sealing members being responsive to pressure differential between the interior of the vial and the particulate compartments, and filter members in each compartment through which fluid flows during passage between the vial and the compartment.Type: GrantFiled: July 23, 1979Date of Patent: May 5, 1981Inventor: Milton J. Cohen
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Patent number: 4261474Abstract: A filter device for injectable fluids which includes a tubular member secured in sealing relation in the open end of a vial partially filled with the injectable fluid and a rupturable sealing disc sealing the tubular member and which includes a filter means within the tubular member for filtration of fluid during passage through said tubular member.Type: GrantFiled: November 1, 1979Date of Patent: April 14, 1981Inventor: Milton J. Cohen
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Patent number: 4254884Abstract: A plug body for a plastic container for blood or the like wherein a rubber plug has upper and lower surfaces covered to be positioned by thermoplastic films, the surface of the thermoplastic film is partly exposed to serve as an inserting opening for an injection needle or the like, and an injection molded portion is surrounded with thermoplastic material of the same quality as the thermoplastic film.Type: GrantFiled: October 15, 1979Date of Patent: March 10, 1981Assignee: Toppan Printing Co., Ltd.Inventor: Takashi Maruyama
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Patent number: 4243150Abstract: A bottle seal for ink bottles used in automatic ink dispensing systems. The seal includes a stopper insertable in the neck of the bottle terminating in a lip seal with a central slot for receipt of an ink withdrawal needle. A plastic or metal foil seal overlies the stopper sealing the slit area. A resilient disk overlies the foil and has a central slit area aligned with the stopper slit area. A rigid cap receives the stopper, foil and disk and attaches the same to the bottle neck, the cap having an opening aligned with the slit areas.Type: GrantFiled: January 23, 1978Date of Patent: January 6, 1981Assignee: Siemens AktiengesellschaftInventors: Ingemar Gunne, Bertil Almgren
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Patent number: 4236647Abstract: A device for containing sterile liquids in such a manner so that said liquid may be incrementally dispensed from the device without contamination to the remaining liquid. More particularly, a bottle having an opening and having within it a flexible plastic bag connected to the bottle only at its opening. Said bottle opening being sealed by a rubber stopper which has a vent in it which allows air to flow from outside the container to the area between the bottle and the flexible bag. Thus when liquid is sucked out of the bag via a hollow needle inserted through the stopper, no vacuum is created for the bag collapses as air flows into the area between the bag and bottle.Type: GrantFiled: January 15, 1979Date of Patent: December 2, 1980Inventor: Paulson A. Kotturan
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Patent number: 4226333Abstract: The disclosure is of a novel closure for air evacuated tubular containers and comprises a tubular body having flexible, elastic sidewalls, an open end, a closed end formed by a cannula-pierceable, flexible, elastic end wall having a concavo-convex configuration in cross-section and a flange disposed radially about the periphery of the open end. The novel closure structure takes advantage of the vacuum force in the container to maintain a gas-proof, hermetic seal, reduces the thickness required of the closure to maintain the hermetic seal and is easier to assembly in an air evacuated container. The disclosure is also of a novel method of assembling the closure of the invention in an air evacuated tubular container.Type: GrantFiled: September 13, 1978Date of Patent: October 7, 1980Assignee: Becton, Dickinson and CompanyInventor: Edward P. Percarpio
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Patent number: 4226334Abstract: A stopper is provided which is adapted to be held in place in an opening in a molded thermoplastic container that is molded about the stopper in place. The stopper has a substantially cylindrical body portion with a planar end surface at one end thereof and a unitary skirt portion depending from the other end of the body portion. An annular flange, unitary with the body portion, extends laterally away from the body portion in one end thereof to define first and second peripheral flange surfaces and a lateral flange surface. The first peripheral flange surface is contiguous with the planar end surface and with the lateral flange surface. The first peripheral flange surface further is disposed at an angle with respect to the planar end surface and converges towards the second peripheral flange surface in a direction away from the body portion. The second peripheral flange surface is contiguous with the lateral flange surface and the skirt portion.Type: GrantFiled: December 14, 1978Date of Patent: October 7, 1980Assignee: Automatic Liquid Packaging, Inc.Inventors: Gerhard H. Weiler, Dieter H. Nagel
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Patent number: 4219912Abstract: Injection sites are provided for injecting substances such as medicaments into systems that are feeding parenteral fluid to a patient, which injection sites have injection ports that are thermoplastically sealed into the injection site in a manner that is simpler, faster, less expensive, and more readily automated than other assemblies. The assembly includes a vibratory energy seal of the non-thermoplastic port within a countersunk thermoplastic seat.Type: GrantFiled: October 10, 1978Date of Patent: September 2, 1980Assignee: Baxter Travenol Laboratories, Inc.Inventor: Elvis E. Adams
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Patent number: 4202334Abstract: A combination cap and stopper for sealing a substance within a syringe whether the needle remains on the syringe or is removed, consisting of a rubber or plastic device having a generally cylindrical portion and a portion having a generally frustoconical shape. The cylindrical portion has a frustoconical axial bore therein with an axially extending groove formed in the frustoconical wall and at the bottom end of the bore a plug-like cylindrical protrusion. The portion of generally frustoconical shape being solid and having a raised target on its base so as to aid in proper insertion of a cannula.Type: GrantFiled: February 28, 1978Date of Patent: May 13, 1980Assignee: C. R. Bard, Inc.Inventor: Edward E. Elson
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Patent number: 4193402Abstract: A bottle stopper comprising a cap and a skirt portion extending from the cap. The skirt member comprises: a flange arranged on the skirt member; a first slit extending from the lower end of the skirt, which is spaced from the cap, to a point on the skirt between the lower end and the cap; and a second slit extending from the lower end of the skirt to a point on the skirt between the flange and the lower end of the skirt. The second slit is bordered by first and second edges, each comprising a protuberance.A method of packaging a pharmaceutical substance comprising the steps of: filling a bottle with the pharmaceutical substance; inserting the inventive bottle stopper into the top of the bottle.Type: GrantFiled: February 2, 1979Date of Patent: March 18, 1980Inventor: Jean-Jacques Rumpler
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Patent number: 4187952Abstract: The disclosure is of a novel closure for air evacuated tubular containers and comprises a tubular body having flexible, elastic sidewalls, an open end, a closed end formed by a cannula-pierceable, flexible, elastic end wall having a concavo-convex configuration in cross-section and a flange disposed radially about the periphery of the open end. The novel closure structure takes advantage of the vacuum force in the container to maintain a gas-proof, hermetic seal, reduces the thickness required of the closure to maintain the hermetic seal and is easier to assemble in an air evacuated container. The disclosure is also of a novel method of assembling the closure of the invention in an air evacuated tubular container.Type: GrantFiled: September 13, 1978Date of Patent: February 12, 1980Assignee: Becton, Dickinson and CompanyInventor: Edward P. Percarpio
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Patent number: 4187719Abstract: Apparatus for the determination of the sedimentation rate of red blood cells comprising a sedimentation tube adapted to hold a blood column, and a closure valve on one end of the sedimentation tube with said closure valve having a self-sealing valve means.Type: GrantFiled: July 31, 1978Date of Patent: February 12, 1980Assignee: B. Braun Melsungen AktiengesellschaftInventor: Ulrich Brethauer
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Patent number: 4187893Abstract: A single port is provided for a container such as an I.V. bag which can serve both as an additive port and also as an administration port. The combined administration and additive port has an inner diaphragm portion which is in open communication with the solution in the container and an outer resealable stopper unit which when pierced by a needle of a hypodermic syringe is self-sealing. The outer resealable unit is removable from the port so that the port subsequently serves as the usual administration port when utilizing the standard I.V. administration equipment.Type: GrantFiled: July 19, 1978Date of Patent: February 12, 1980Assignee: Abbott LaboratoriesInventor: Albert F. Bujan
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Patent number: 4186840Abstract: The disclosure is of a novel closure for air evacuated tubular container and comprises a tubular body having flexible, elastic sidewalls, an open end, a closed end formed by a cannula-pierceable, flexible, elastic end wall having a concave-convex configuration in cross-section and a flange disposed radially about the periphery of the open end. The novel closure structure takes advantage of the vacuum force in the container to maintain a gas-proof, hermetic seal, reduces the thickness required of the closure to maintain the hermetic seal and is easier to assemble in an air evacuated container. The disclosure is also of a novel method of assembling the closure of the invention in an air evacuated tubular container.Type: GrantFiled: September 13, 1978Date of Patent: February 5, 1980Assignee: Becton, Dickinson and CompanyInventor: Edward P. Percarpio
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Patent number: 4187149Abstract: A cell culture sampling device is provided which comprises a double septum holder having an axial bore therethrough, upper and lower septa retaining members, said upper retaining member having lip means to retain immobilized an external septum and said lower retaining member having shoulder means to retain immobilized an internal septum, said lip and shoulder means being spaced apart to thereby define a fixed chamber between said immobilized septa.Type: GrantFiled: February 27, 1978Date of Patent: February 5, 1980Assignee: Monsanto CompanyInventors: William R. Tolbert, Joseph Feder
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Patent number: 4181233Abstract: A one-way valve located anywhere on a stopper used in vacuum blood collection tubes, which permits venting or displacing any positive air pressure in a filled vacuum tube so that, when the pressure of the filled tube is greater than the pressure of the vein, the valve is actuated in the open position and when the pressures equalize, the valve closes. Such device also provides other advantages hereinafter set forth.Type: GrantFiled: November 15, 1978Date of Patent: January 1, 1980Assignee: Becton, Dickinson and CompanyInventor: Philip H. Gouveia
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Patent number: 4172534Abstract: Disclosed herein is a container of blow molded plastic material which may contain a hermetically sealed biological. Attached to its outer side is an elastomeric diaphragm, adapted for cooperative use with a hypodermic needle as a self-sealing puncture site for injection or aspiration. The diaphragm may be protected by a storage cover which can readily be snapped off when the container is to be used. Also disclosed is a method and an apparatus for making the just described container with diaphragm and storage cover, in the preferred embodiment, as an assembled device, in a blow mold operation in which the container body is blown to fit against and lock to the diaphragm and storage cover.Type: GrantFiled: March 16, 1978Date of Patent: October 30, 1979Assignee: Respiratory Care, Inc.Inventor: Orlando D. Cambio
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Patent number: 4163500Abstract: A bottle seal particularly adapted for ink bottles used in automatic ink feed systems wherein the bottle seal is to be pierced by an ink withdrawal needle, the seal having a stopper which has a portion extending into the bottle neck terminating in a lip seal. The stopper portion has an outer diameter groove adjacent the lip seal with at least one air channel communicating from the groove to the exterior to allow aeration of the bottle.Type: GrantFiled: January 23, 1978Date of Patent: August 7, 1979Assignee: Siemens AktiengesellschaftInventors: Ingemar Gunne, Bertil Almgren
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Patent number: 4153173Abstract: A cap closure is provided for bonding to the neck of a container. The cap closure includes a base portion enclosed by a side wall, a peripheral rim extending outwardly from the side wall with the rim being adapted for bonding to the neck of the container, an administration port connected to the base portion, a medication addition port connected to the base portion, a resealable injection site connected to the medication addition port, and port protectors covering and hermetically sealing the administration and medication addition ports. In the illustrative embodiment, the base portion, side wall, peripheral rim, administration port and medication addition ports are molded as an integral, unitary member, and a method is provided for fusing a membrane to the medication addition port and for fusing port protectors with the base member.Type: GrantFiled: March 13, 1978Date of Patent: May 8, 1979Assignee: Baxter Travenol Laboratories, Inc.Inventors: Gary A. Ward, David A. Winchell
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Patent number: 4152269Abstract: A blood collection assembly and closure therefor, for the collection, separation, isolation and storage of serum from blood. The closure is constructed of a cannula penetrable self-sealing elastomer and includes a thixotropic barrier material in a hollow central portion of the closure, so that the barrier material is sealed within the closure until blood has been collected in the collection container and centrifuged. Centrifugation forces the barrier material into a collecton container through the passageway created by the cannula.Type: GrantFiled: February 1, 1977Date of Patent: May 1, 1979Assignee: Warner-Lambert CompanyInventor: Arthur L. Babson
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Patent number: 4142940Abstract: To provide a disposable container which can be prefabricated under sterile conditions, a pair of concentric plastic rings are formed with interfitting, interlocking projection and recess means permitting the rings to be snapped together, the rings being additionally formed with matching fitting surfaces to interpose the edge portion of a gas permeable membrane therebetween so that, when the membrane is placed on the outer ring and the two rings are snapped together, the membrane is irremovably held. Preferably, the outer ring is made of a softer, yielding plastic, the inner ring of a more rigid plastic, with a projection snapping into a groove formed on the inner, more rigid ring, and the matching clamping surfaces for the membrane forming a sinuous, tortuous path with a flexible projecting lip on the outer ring fitting into a recess to clamp the membrane and seal the membrane in the structure.Type: GrantFiled: September 7, 1976Date of Patent: March 6, 1979Assignee: W. C. Heraeus GmbHInventors: Manuel Modolell, Paul G. Munder, Herbert Schaus
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Patent number: 4136794Abstract: The disclosure is of a novel closure for air evacuated tubular container and comprises a tubular body having flexible, elastic sidewalls, an open end, a closed end formed by a cannula-pierceable, flexible, elastic end wall having a concavo-convex configuration in cross-section and a flange disposed radially about the periphery of the open end. The novel closure structure takes advantage of the vacuum force in the container to maintain a gas-proof, hermetic seal, reduces the thickness required of the closure to maintain the hermetic seal and is easier to assemble in an air evacuated container. The disclosure is also of a novel method of assembling the closure of the invention in an air evacuated tubular container.Type: GrantFiled: February 23, 1978Date of Patent: January 30, 1979Assignee: Becton, Dickinson and CompanyInventor: Edward P. Percarpio