Self-sealing, Piercable-type Closure Patents (Class 215/247)
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Patent number: 5088996Abstract: The present invention comprehends the provision of a fluid tight holding chamber which accumulates solution from the vial that aspirates during mixing or drawing fluid from the vial or is pressured out of the syringe upon extraction of the cannula from the vial. The holding chamber is defined in conjunction with the vial septum by a shield cap that surrounds and seals to the neck of the vial. The shield cap defines a guide for the cannula of the syringe and directs the cannula through a sealing member, the holding chamber, the septum and into the vial. One aspect of the invention provides a sleeve portion on the shield cap that receives and retains the syringe barrel. An arm is provided on the sleeve portion and has a notch that holds the syringe barrel in a predetermined position during shipment and storage of the assembly.Type: GrantFiled: May 18, 1987Date of Patent: February 18, 1992Inventors: Rudolph J. Kopfer, Robert E. Smith
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Patent number: 5088612Abstract: A vial cap of plastic having a skirt portion press fit onto the neck of a vial. A transversely extending wall having a central opening is integral with the upper end portion of the skirt, and a sealing disc is positioned between the open end of the vial and the transverse wall. A plastic lid having a plastic hinge integrally connected between the lid and the skirt is provided for closing the central opening of the cap during storage. By the construction and arrangement of the plastic vial cap, the fear of aluminum toxicity is overcome and the lid prevents the accumulation of dust and other debris on the sealing disc while the vial is in storage.Type: GrantFiled: June 10, 1991Date of Patent: February 18, 1992Assignee: Comar, Inc.Inventors: James R. Storar, David A. Manera
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Patent number: 5086813Abstract: Apparatus for aseptically transferring material between enclosures. Apparatus for transferring the material includes a fluid receiver assembly (12) comprising an adapter (24), and a fitting (93) mounted in the adapter (24). The fitting has a plurality of needle guide channels (86) leading from the outside of the fluid receiver assembly (12) toward the interior of the enclosure (10), and a seal (26) at the ends of the channels (86). A pierceable, self-closing seal (26) is between ends of each of the channels (86) and the interior of the enclosure. Projected extensions of the channels pass through corresponding holes (40) in the adapter, so that needles (101) inserted into the channels (86) can penetrate the seal (26) and enter the interior of the enclosure (10). A plurality of needles (101) in a novel needle bundle (95) may be used in making the transfer. An assembly for transferring material between two stationary enclosures comprises a pair of novel needle bundles (295) and connecting tubing (266).Type: GrantFiled: June 7, 1990Date of Patent: February 11, 1992Inventor: Edwin J. Galloway
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Patent number: 5071404Abstract: An injection site for the infusion of a medicament into a flow path for a parenteral fluid and, more particularly, an injection site which is essentially self-priming and air-occluding and which is of extremely simple construction and easily assembled. Furthermore, the invention is also directed to an injection site of the type described herein which is especially adapted for use as an injection port of a Y-connector utilized for an intravenous administration set. The device incorporates a self-sealing puncturable member of resilient material, such as rubber, which member is of a substantially spheroid configuration, the tubular segment so as to be in close proximity to the and which is swage-molded into a receiving housing in the tubular segment so as to be in close proximity to the inlet tubing for the flow path of the parenteral fluid.Type: GrantFiled: August 1, 1989Date of Patent: December 10, 1991Assignee: Abbott LaboratoriesInventors: Mark E. Larkin, Richard W. Grabenkort
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Patent number: 5071017Abstract: A valving-type closure having a resilient diaphragm provided with a portion having a through slit for the passage of fluids, the slit portion being adapted to bulge and open the slit in response to fluid pressure applied to one side thereof. The slit portion has abuttable, cooperable structures on one side, which come into forcible abutment and act to physically open the slit as the portion bulges. Preferably the abuttable structures are in the form of rings molded on the underside of the diaphragm. The slit through the diaphragm also extends through the ring, thereby forming two semi-circular ring segments. The ring segments in turn form abutment shoulders that pivot the walls of the slit away from one another when the diaphragm is bulged, thereby resulting in a more pronounced spreading force being applied to the walls, and increasing the size of the opening formed by the slit.Type: GrantFiled: February 15, 1991Date of Patent: December 10, 1991Inventor: Gene Stull
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Patent number: 5064083Abstract: A device for use with containers, including an elastomeric member sized to engage the container. The member has a first portion for contact with the container to form a seal and a second portion having a polyparaxylylene coating to form a barrier between the member and the contents of the container.Type: GrantFiled: March 8, 1990Date of Patent: November 12, 1991Assignee: The West Company, IncorporatedInventors: Barbara Alexander, Patty H. Kiang, Richard Lusch, Val Romberg
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Patent number: 5061263Abstract: A liquid collection tube for collecting blood or like liquid with a liquid collection needle, comprises a tube member with a bottom and a cap member removably fitted on an open end of the tube, with thread structures. A sealing member is interposed between the cap member and open end of the tube member to enhance the close contact between the two. The sealing member is not bonded to the open end of the tube member, and it can be removed together with the cap member to open the open end of the tube member when the cap member is removed from the tube member. The cap member has a through hole permitting a re-sealing member of the sealing member to be pierced from the outside.Type: GrantFiled: February 12, 1990Date of Patent: October 29, 1991Assignee: Terumo Kabushiki KaishaInventors: Sakae Yamazaki, Takato Murashita
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Patent number: 5060812Abstract: A medication container stopper includes an elastomeric plug which makes a friction fit in an opening of the container. A first cavity in an exterior surface of the plug opens and diverges away from an interior surface of the plug. A second cavity opens qnd diverges away from the exterior surface of the plug. The bottoms of the cavities are spaced apart to define opposite faces of a thin diaphragm formed integrally with the plug. One of the cavities has an elongated groove with a bottom which defines one face of the diaphragm, which is of a thickness that permits the diaphragm to be ruptured by inserting a conventional hypodermic syringe nozzle into the cavity in the exterior surface of the plug.Type: GrantFiled: September 6, 1990Date of Patent: October 29, 1991Assignee: International Medication Systems, LimitedInventor: George B. Ogle, II
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Patent number: 5036992Abstract: According to the present invention, a vial cap is provided which has two openings, one for receiving the neck of a syringe and allowing medicine to flow into the syringe, and another for allowing air to flow into the vial as medicine is extracted. A safety lid to the vial cap is preferably provided for assuring sterility. A membrane may also be provided to cover the interior surface of the vial cap so that no medicine leaks into the region between the vial cap and its safety lid while the medicine is being transported and stored.The shape and size of the two openings may be varied according to the application, in particular according to the material used for the cap and the medicine being stored in the vial.Type: GrantFiled: March 27, 1990Date of Patent: August 6, 1991Inventors: Marvin L. Mouchawar, Alan E. Mouchawar
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Patent number: 5016771Abstract: A cap closure having a top member with a center opening, a dependent skirt and a liner. The liner has a central raised portion, which may be concave, which mates with the center opening in the top member by an interference fit, thus retaining the liner in the center opening and under the top member.Type: GrantFiled: September 4, 1990Date of Patent: May 21, 1991Assignee: J. G. Finneran AssociatesInventor: James G. Finneran
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Patent number: 4995521Abstract: A closure stopper particularly for bottles or the like containing infusion solutions, having an elastic stopper part which is to be inserted in sealing fashion into the bottle neck and rests with a resting shoulder on the bottle neck and a cover part connected therewith. To obtain a solution of particularly optimal utility, cover part 15 coordinated with the stopper part by means of a clamping plug connection in the manner that the stopper part has a recess for the spreading insertion of a flange which protrudes from the cover part and is clamped between the stopper part and the cover part of a flanged cap.Type: GrantFiled: February 21, 1989Date of Patent: February 26, 1991Assignee: Pohl GmbH & Co. KGInventor: Alfred von Schuckmann
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Patent number: 4991104Abstract: A stopper or closure is provided as a closure for containers in which the stopper profile is computer generated to take into consideration radial stress at the stopper/container interface, and to eliminate tensile stress therealong which tensile stress is an indication that a portion of the stopper wall is not engaging the opposed container surface. The stopper of the invention is particularly appropriate for use in evacuated blood sample collection tubes for eliminating "gray bands" or regions where the stopper and tube do not contact, and "red spots" formed in small cavities generated on the internal surface of the stopper at the withdrawal position of a blood collection needle having been inserted in the stopper.Type: GrantFiled: March 19, 1990Date of Patent: February 5, 1991Assignee: Becton, Dickinson and CompanyInventor: Henry F. Miller
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Patent number: 4979642Abstract: The invention provides a spray for sterile products, more particularly aseptic solutions used in medical and surgical treatments. The spray, comprising a flask whose main orifice is closed by a precompression pump (2), and has another orifice (9) located in its lower part and closed sealingly by a stopper (10) made from a flexible and perforable material which remains sealing after perforation, said stopper and said flask having a special configuration promoting spraying of the last drops contained in the container.Type: GrantFiled: June 21, 1988Date of Patent: December 25, 1990Assignee: Centre Regional de Transfusion Sanguine de LilleInventor: Jean-Marc Thiebaut
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Patent number: 4976894Abstract: In a system in which a CO.sub.2 injection nozzle penetrates into an inverted sealed vessel from which a beverage will be served, such as a soda bottle, the preferably needle-like nozzle projects vertically through an aperture in a cap and through a normally closed hole in a septum comprising a portion of an elastomeric gasket providing a seal between the cap and the vessel. The nozzle provides a path for communication of liquid in the vessel with a source of CO.sub.2. The nozzle is formed out of a mixture of polycarbonate resin and polytetrafluoroethylene to provide for ease of insertion through the hole in the septum and into liquid in the vessel. A low friction washer between the cap and the gasket decreases torque applied to the gasket as the cap is tightened to provide compressive force.Type: GrantFiled: September 22, 1989Date of Patent: December 11, 1990Assignee: NSA Acquisition, Inc.Inventor: Bruce R. Robinson
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Patent number: 4967919Abstract: A blood collection assembly is provided for blood collection tubes, and more particularly for evacuated blood collection tubes, whereby the potential exposure of laboratory technicians or hospital personnel to potentially infectious blood specimens is reduced. The device consists of a cap which is configured to be placed over and fitted onto the rubber stopper of an evacuated collection tube. The top surface of the cap includes a centrally located bore section which is surrounded by a downwardly directed retaining ring to prevent accidental exposure of the user to the upper flange portion of the stopper wherein the user is protected from exposure to the contaminated bottom surface of the stopper as the cap and stopper are removed from the collection tube.Type: GrantFiled: July 5, 1989Date of Patent: November 6, 1990Assignee: Sherwood Medical CompanyInventor: Stephen B. Earhart
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Patent number: 4954149Abstract: A septum for an injection port of a gas chromatograph includes interlocked syringe and duckbill seals. The syringe seal prevents fluid leakage during injection by syringe. The duckbill seal prevents fluid leakage after the syringe needle is withdrawn from the septum. A spring clip is used to urge the duckbill closed as the needle is withdrawn. An advantage of this two component septum is that the duckbill slit can be precisely formed in the duckbill seal before the seals are engaged.Type: GrantFiled: October 25, 1989Date of Patent: September 4, 1990Assignee: Merlin Instrument CompanyInventor: James S. Fullemann
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Patent number: 4941517Abstract: Apparatus for aseptically transferring material between enclosures. Apparatus for transferring the material includes a fluid receiver assembly (12) comprising an adapter (24), and a fitting (93) mounted in the adapter (24). The fitting has a plurality of needle guide channels (86) leading from the outside of the fluid receiver assembly (12) toward the interior of the enclosure (10), and a seal (26) at the ends of the channels (86). A pierceable, self-closing seal (26) is between ends of each of the channels (86) and the interior of the enclosure. Projected extensions of the channels pass through corresponding holes (40) in the adapter, so that needles (101) inserted into the channels (86) can penetrate the seal (26) and enter the interior of the enclosure (10). A plurality of needles (101) in a novel needle bundle (95) may be used in making the transfer. An assembly for transferring material between two stationary enclosures comprises a pair of novel needle bundles (295) and connecting tubing (266).Type: GrantFiled: October 20, 1988Date of Patent: July 17, 1990Assignee: Galloway TrustInventor: Edwin J. Galloway
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Patent number: 4932543Abstract: A cork for a wine bottle is chambered to receive sediment when the bottle is inverted. A valve operable from the exterior of the cork can then be closed to trap the sediment within the cork. A resilient easily attached valve member ensures full closure, yet also enables introduction of additives to the wine.Type: GrantFiled: January 3, 1989Date of Patent: June 12, 1990Inventor: Don Martus
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Patent number: 4928126Abstract: In an ink container having a container for storing ink therein, and an outlet pipe for directing the ink in the container outwardly thereof, the outer end portion of the outlet pipe is mounted on a sealing elastic member formed by a dual structure comprising an elastic member of low gas permeability and an elastic member of small permanent set to thereby seal the container.Type: GrantFiled: April 3, 1989Date of Patent: May 22, 1990Inventor: Naohito Asai
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Patent number: 4923072Abstract: An evacuated blood collection tube has a stopper made of deformable synthetic rubber, incorporating a skirt fitting over the outer wall of the tube neck, and integral with the skirt a plug that penetrates the neck of the tube. The sealing function is performed by two embodiments, the upper cylindrical sealing portion of the skirt and the plug. An annular recess surrounds the plug. A compression ring made of a more rigid material is set around the upper peripheral wall of the skirt that overlaps the cylindrical sealing portion. The compression ring cooperates with the rubber stopper and the tube to provide a clenching mechanism ensuring automated guidance of the tube in full sealing engagement over the plug. Furthermore it maintains a constant sealing pressure of the skirt over the tube optimizing vacuum preservation.Type: GrantFiled: March 17, 1989Date of Patent: May 8, 1990Assignee: Dematex Development & Investment EstablishmentInventor: Francois Rilliet
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Patent number: 4920976Abstract: In a single-use device for collecting and holding blood samples, provision is made for an evacuated tube with a closure (stopper) that can be pierced by the tip of a needle, the other tip of which is intended to be inserted into a vein of a patient. Disposed below the said pierceable stopper, and in the tube, is a diaphragm intended to passed through by the needle-tip that pierces the stopper, so as to form a supplementar barrier between the interior of the tube and the environment when the pierceable stopper is removed.Type: GrantFiled: December 12, 1988Date of Patent: May 1, 1990Assignee: Instrumentation Laboratory, S.p.A.Inventors: Claudio Calzi, Gianfranco Zaccai
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Patent number: 4915243Abstract: A resin-laminated rubber closure for a medical vial is provided herein. This closure comprises an annular leg part to be inserted into the mouth of the vial, which leg part is notched or cut at least at one position and a flange part to be contacted with the front surface of the vial mouth, wherein the outer and inner surfaces of the annular leg part is provided with a chemical-resistant resin film laminated thereon except for the upper end of the leg part so that the rubber surface is exposed at the upper end of said leg portion, and wherein the leg part has at least one protrusion on the outer surface of the laminated portion. The present invention also relates to a molding process for economically producing said closure.Type: GrantFiled: April 19, 1988Date of Patent: April 10, 1990Assignees: Daikyo Gomu Seiko, Ltd., Yamanouchi Pharmaceutical Co., Ltd.Inventors: Yutaka Tatsumi, Hideo Yoshitaka, Tatsuya Matsunaga, Denpei Sudo, Tamotsu Okuda
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Patent number: 4910147Abstract: A cell culture media container is provided. The container comprises a body constructed from flexible film and defining a containment area for containing the cell culture media, the body including a front face and a back face, the front and back face being sealed to each other along at least three sides thereof. The container includes a fill port for filling the containment area with cell culture media, the port being sealed to a face of the body and being so constructed and arranged that it extends from the face normal thereto. The container is constructed from a high barrier, optically clear, radiation sterilizable film.Type: GrantFiled: September 21, 1988Date of Patent: March 20, 1990Assignee: Baxter International Inc.Inventors: David V. Bacehowski, Arnold C. Bilstad, David Fisher, Robert Gliniecki, Michael R. Keilman, Sidney T. Smith
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Patent number: 4893636Abstract: A stopper for medical containers such as blood collection tubes having integral flange and plug portions, the flange portion being substantially larger in diameter than the plug portion, which plug portion is sized to sealably close the container. The stopper has opposed wells formed in the flange and plug portions, the well in the flange portion having a relatively flat bottom surface at least as large in diameter as the diameter of the opposed well in the plug portion. The flange portion is constructed to be guided into a tube holder into which it is inserted such that one end of a needle projecting into the interior of the tube holder will penetrate the stopper in the area of the opposed wells so as to avoid otherwise contacting the stopper. The enlarged flange portion also serves to facilitate removal of the stopper from the container without contaminating a handler.Type: GrantFiled: March 9, 1988Date of Patent: January 16, 1990Assignee: Sherwood Medical CompanyInventors: Boyce W. Cook, William R. Fiehler
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Patent number: 4892222Abstract: A port assembly for a container is provided. The port assembly includes an elongated tube extending from an end of a base, the tube defining a tubular bore for receiving a member for accessing the container. The tubular bore includes a membrane for separating the tubular bore into a first portion and second portion, the first portion being closer to the container than the second portion. A resealing injection site is mechanically locked within the second portion of the channel. A method for making the port assembly is also provided.Type: GrantFiled: November 25, 1988Date of Patent: January 9, 1990Assignee: Baxter International Inc.Inventors: Josef Schmidt, James Ducay, Hugh Forman
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Patent number: 4886178Abstract: A bubbler container for containing and transporting ultra-pure corrosive and poisonous liquid reagents which must be protected from exposure to air and from transmission of gas or vapor through containment walls, means for using the same in connection with unique valving and multiple layer seals for conduits is disclosed.Type: GrantFiled: October 19, 1988Date of Patent: December 12, 1989Assignee: Air Products and Chemicals, Inc.Inventor: Hans-Juergen Graf
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Patent number: 4886177Abstract: A cap for sealing evacuated tubes has a plurality of sealing surfaces to seal tubes of various sizes and a septum of self-closing material to permit a needle to pass for the withdrawal or injection of fluids. The sealing surfaces are defined by a plurality of annular bands extending in series from a top wall, as well as a skirt which depends from the top wall and surrounds the annular bands.Type: GrantFiled: October 31, 1988Date of Patent: December 12, 1989Assignee: Porex Technologies Corp. of GeorgiaInventor: Kevin D. Foster
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Patent number: 4872572Abstract: A lyophilization stopper made of a rubber elastic material is composed of a shank (1) and a circular disc shaped flange (2) made in one piece with the shank. The shank includes a cavity (4) which surrounds the longitudinal axis (A) of the shank and is open toward the free end face (3) of the shank, while extending toward a central closed wall portion (2b) of the flange. A first section (Z.sub.1) of the shank disposed between a first transverse plane (Q.sub.1) and a second transverse plane (Q.sub.2) has a closed outer circumferential face which has a maximum diameter (D). A subsequent second section (Z.sub.2) includes a passage which communicates with the cavity as well as a plurality of projecting blocking elements (14a-14c). The inner wall surface (19) which laterally delimits the cavity (4) and has an increasing diameter with increasing approach to the free shank end face lies completely outside a cone (K) whose axis is the longitudinal axis (A) of the shank, whose tip (K.sub.Type: GrantFiled: December 23, 1988Date of Patent: October 10, 1989Assignee: Helvoet Pharma N.V.Inventor: Rik Schrooten
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Patent number: 4869384Abstract: A medicament package comprising a rigid container having an end wall, side walls and an open end.A resilient closure which seals said open end of said rigid container, said resilient closure having an upper and lower portion, the lower portion being received in the open end of said rigid container and sealing same, the upper portion of said resilient closure projecting beyond the outer extremity of the open end of said container.A fluid pathway extending longitudinally through both portions of said resilient closure, said fluid pathway being bridged by an imperforate diaphragm within said upper portion of said resilient closure.Type: GrantFiled: January 12, 1988Date of Patent: September 26, 1989Assignee: International Medication Systems LimitedInventor: George B. Ogle, II
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Patent number: 4796624Abstract: An apparatus is disclosed for introducing a liquid within a material. The apparatus comprises a body member having an internal cavity for receiving a battery. An end member is secured to the body member for supporting a needle guide extending through the end member for slidably receiving a needle. A reciprocal coupling means interconnects the motor and the needle for reciprocating the needle relative to the end member upon rotation of the motor. A reservoir is in fluid communication with the needle for retaining the liquid therein and for enabling the liquid to flow along the needle. The reciprocating needle creates a plurality of perforations in the material enabling the liquid to flow along the needle to enter the perforations. The apparatus is suitable for introducing a liquid pigment into a skin tissue such as introducing a permanent eyeliner into an eyelid.Type: GrantFiled: November 19, 1986Date of Patent: January 10, 1989Assignee: Concept, Inc.Inventors: Arthur F. Trott, Sam R. Marchand
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Patent number: 4773552Abstract: A closure and method of assembly for sample vials comprising a cap and a septum with the septum having a plurality of radially extending protrusions for retentive engagement with the cap to retain the septum and annular disk within the cap during positioning of the closure on the sample vial.Type: GrantFiled: May 4, 1987Date of Patent: September 27, 1988Assignee: Bodenseewerk Perkin-Elmer & Co., GmbHInventors: Dietrich H. Boege, Wolfgang Riegger
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Patent number: 4772558Abstract: A culture bottle assembly for the detection of micro-organisms in a fluid sample is provided. The culture bottle assembly is a container having a dividing wall which divides the culture into two compartments. A cap is provided for the container and means are provided for moving the cap axially with respect to the container. A resilient material is provided which is compressed by the cap moving means to provide a liquid tight seal between the two compartments.Type: GrantFiled: June 1, 1987Date of Patent: September 20, 1988Inventor: Ranier Hammann
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Patent number: 4741446Abstract: A stopper or closure is provided as a closure for containers in which the stopper profile is computer generated to take into consideration radial stress at the stopper/container interface, and to eliminate tensile stress therealong which tensile stress is an indication that a portion of the stopper wall is not engaging the opposed container surface. The stopper of the invention is particularly appropriate for use in evacuated blood sample collection tubes for eliminating "gray bands" or regions where the stopper and tube do not contact, and "red spots" formed in small cavities generated on the internal surface of the stopper at the withdrawal position of a blood collection needle having been inserted in the stopper.Type: GrantFiled: December 29, 1986Date of Patent: May 3, 1988Assignee: Becton, Dickinson and CompanyInventor: Henry F. Miller
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Patent number: 4735832Abstract: A container made of synthetic resin and provided at one portion thereof with at least one tightly closable opening, which container has on a surface thereof a continuous coating having a gas barrier characteristic comprising low permeability to oxygen and carbon dioxide by the plasma treatment reaction of a mixture of a silicon compound having the general formula I with a silicon compound having the general formula II: ##STR1## wherein m=1-5, n=1-5, R.sup.1 and R.sup.2 are C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy or phenyl or OH.Type: GrantFiled: February 24, 1987Date of Patent: April 5, 1988Assignee: Terumo Kabushiki KaishaInventors: Toshiji Ichikawa, Yoshimitsu Asada, Ken Tatebe, Tooru Takahashi, Juuro Aoyagi, Takeshi Shimomura
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Patent number: 4682703Abstract: A stopper for a medical container which can tightly close an opening in said medical container and can be pierced with a syringe, which stopper is characterized by the fact that at least part of the portion thereof which possibly comes into contact with a piercing needle during the removal of said piercing needle therefrom is formed of a material containing a highly water absorbable macromolecular compound.Type: GrantFiled: April 24, 1986Date of Patent: July 28, 1987Assignee: Terumo Kabushiki KaishaInventors: Masaaki Kasai, Kenji Ishikawa
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Patent number: 4664275Abstract: A stopper for hermetically sealing an opening of a medical container. The stopper is made of a composition comprising 30 to 80% by weight of a partially cross-linked butyl rubber, 10 to 40% by weight of a thermoplastic resin, and 5 to 50% by weight of an inorganic powder.Type: GrantFiled: September 5, 1985Date of Patent: May 12, 1987Assignee: Terumo Kabushiki KaishaInventors: Masaaki Kasai, Kenji Ishikawa
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Patent number: 4664274Abstract: A blood-sampling tube assembly comprises a cap fitted onto the open end of a blood-sampling tube and having inner and outer walls between which the walls of the tube is snugly received. According to the invention, the cap is formed with an outwardly open and upwardly open compartment containing a self sealing membrane pierceable by a needle and held in place by a laminate, e.g. aluminum foil and a heat sealing layer, bonded to an end wall of the cap bridging the inner and outer walls and closing the membrane within the compartment.Type: GrantFiled: January 24, 1986Date of Patent: May 12, 1987Assignee: C. A. Greiner & Sohne Gesellschaft mbHInventor: Franz Konrad
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Patent number: 4635807Abstract: A stopper for holding fluid in a container comprising a body of vulcanized elastomer having a convex surface, and, laminated to the convex surface without adhesive, a thin layer of thermoplastic, which forms a surface intended to contact the fluid and a side of an opening in the container.Type: GrantFiled: September 3, 1985Date of Patent: January 13, 1987Assignee: Schering CorporationInventor: Julius Z. Knapp
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Patent number: 4582207Abstract: An overcap for an antineoplastic drug container includes a cylindrical airlock with a depth to diameter ratio preferably less than 1:1, elasticity and inner surface construction to provide pressure against the container closure to seal against leakage, a beveled continuous annular locking flange, and an upstanding annular bead defining a target area for hypodermic needle insertion.Type: GrantFiled: April 2, 1985Date of Patent: April 15, 1986Assignee: Bristol-Myers CompanyInventors: David S. Howard, Don C. Stark
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Patent number: 4574965Abstract: A container with a centrally located, integrally formed non-coring and non-leaking piercing site for use with sterile instruments. A double dome construction is employed to permit needle penetration without coring by the needle and provide sealing between the container and the needle. Provision is also made to insure sealing when a larger diameter plastic needle is employed. In another embodiment there is provided a container with a non-coring piercing site and a separate sealing cover.Type: GrantFiled: April 12, 1985Date of Patent: March 11, 1986Assignee: Health Care Concepts, Inc.Inventor: Eugene J. Meierhoefer
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Patent number: 4554125Abstract: A molding process for manufacturing laminated stoppers having an elastomer core and thin thermoplastic liner where a sheet of thermoplastic liner material having an elongation of at least 450% and the vulcanizable elastomer core material are placed in a mold and molded at a temperature above the vulcanization temperature of the elastomer core but below the crystalline molding point of the thermoplastic liner.Type: GrantFiled: March 17, 1983Date of Patent: November 19, 1985Assignee: Schering CorporationInventor: Julius Z. Knapp
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Patent number: 4552277Abstract: A shield device particularly useful in conjunction with a medicine containing vial or ampule to prevent medicine from spraying out of the vial as a hypodermic needle is extracted from the vial seal. The shield device includes a enclosure having a collapsable wall structure. One end of the shield device is formed with an opening for receiving the neck of the vial and sealing around the vial neck. The other end of the shield device from the vial neck receiving opening is formed with an aperture which is covered by a puncturable seal similar to the seal covering the opening into the vial neck. In use, the vial neck is inserted through the opening into the shield. Maintaining the shield device in the collapsed position with the shield seal in overlaying alignment with the vial seal, the needle of a hypodermic syringe is inserted through the shield seal and the vial seal, and into the vial for filling the vial with medicament or extracting medicament from the vial.Type: GrantFiled: June 4, 1984Date of Patent: November 12, 1985Inventors: Robert D. Richardson, Thomas B. Leanhart
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Patent number: 4519513Abstract: A thermoplastic container is shown having an insert sealing the container. The insert includes a membrane which can be pierced to provide access to the inside of the container to draw off a substance such as a sterile liquid. The insert is held by a retaining structure which receives and seals with the insert.Type: GrantFiled: August 30, 1982Date of Patent: May 28, 1985Assignee: Automatic Liquid Packaging, Inc.Inventors: Gerhard H. Weiler, Louis T. Pagels
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Patent number: 4516977Abstract: The invention relates to a storage bag, in particular for medical purposes for storing blood or infusion solutions, comprising a thermoplastic polymer material and having at least one outlet comprising a tube member.Type: GrantFiled: February 16, 1984Date of Patent: May 14, 1985Assignee: Fresenius, AGInventor: Reinhold Herbert
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Patent number: 4513871Abstract: A container with integrally formed non-coring and non-leaking piercing site for use with sterile instruments. A double dome construction is employed to permit needle penetration without coring of the needle and provide sealing between the container and the needle. Provision is also made to insure sealing when a larger diameter plastic needle is employed.Type: GrantFiled: May 30, 1984Date of Patent: April 30, 1985Assignee: Health Care Concepts, Inc.Inventor: Eugene J. Meierhoefer
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Patent number: 4506807Abstract: Disclosed is a powder container for a flame spraying torch having an outlet normally closed by an elastomeric plug provided with inner and outer closely spaced diaphragms. The outer diaphragm has an aperture sized for a wiping fit with a powder dispensing tube as the latter approaches and opens a normally closed slit crosswise of the inner diaphragm thereby safeguarding against the loss of powder during both insertion and withdrawal of a powder dispensing tube through the two diaphragms. The powder dispensing tube has an inlet end upstanding axially within a well sized for telescopic assembly about the dispensing end of the powder container.Type: GrantFiled: April 13, 1983Date of Patent: March 26, 1985Inventor: James Y. Anderson
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Patent number: 4501372Abstract: A tear-open closure for a container comprises a thermoplastic cap having score lines on its top wall defining separated top parts, and a gasket. The gasket has at least two puncture points with at least one puncture point covered by each top part. The closure can be opened such that only one puncture point is exposed by removal of one top part, while the other puncture point remains covered by the other top part. The cap top wall rests on the gasket between the two score lines.Type: GrantFiled: March 8, 1984Date of Patent: February 26, 1985Inventor: Gerhard Hansen
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Patent number: 4492634Abstract: An improved pre-evacuated blood sampling collection tube having two oppositely positioned rubber stoppers sealing the corresponding oppositely positioned open ends of the said cylindrical tube, and interposed within the said tube is a slideable perpendicularly placed filtration disc that filters and separates the cellular elements of the whole blood from its fluid counterpart during the process of centrifugation. One embodiment of the tube having a special structural extension baffle at one of the two sealing rubber stoppers, said structural extension found proximal to the puncturable entrant area of the blood specimen into the tube, acts as the structural baffle that prevents or curtails hymolysis of the red blood cells during the sudden onrush of blood from the blood source through the bore of the collection needle, and into the vacuum of the said collection tube.Type: GrantFiled: September 28, 1982Date of Patent: January 8, 1985Assignee: EMDE Medical ResearchInventor: Antony-Euclid C. Villa-Real
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Patent number: 4467003Abstract: A method of preparation of valves for a flat, flexible, sterilizable container capable of sterilely containing a liquid to be removed under absolutely sterile conditions which comprises the steps of:forming a two-layer laminate including a first layer of a copolymer of ethylene with a minor proportion of butylene and a second layer of an amide polymer; forming a pocket in the two-layer laminate wherein the first layer forms the inner surface of the pocket; providing an elastomeric core element having spaced major faces; inserting the core element into the pocket in the two-layer laminate; providing a three-layer laminate including a first outer layer of a major portion of a propylene polymer, a second outer layer of a copolymer of ethylene with a minor proportion of butylene, and an intermediate layer of an amide polymer; orienting the three-layer laminate so that the second outer layer thereof is apposed to the first layer of the two-layer laminate; expelling air surrounding the core element in the pocket; wType: GrantFiled: December 18, 1981Date of Patent: August 21, 1984Assignees: Safta S.p.A., Bieffe S.P.A.Inventors: Francesco Pallaroni, Luciano Baldini, Alberto Siccardi
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Patent number: 4465200Abstract: A composite closure arrangement is provided for blood sample collection tubes, and particularly evacuated blood collection tubes for reducing exposure of a technician to any blood droplets or blood aerosol during removal of a sample of the blood from the container. The device also hides and contains any such aerosol or droplets. Moreover, the device provides enhanced ease of removal of the stopper, when desired. A cap is configured to be placed over and fitted onto the rubber stopper of the tube, with the top portion of the cap extending over and spaced from the top of the stopper to define a cavity between the overlying portion of the cap and the top of the stopper. The center of the overlapping portion of the cap includes a sample needle access bore providing access to the stopper diaphragm. Cooperating opposed abutments on the cap and the stopper maintain the cap on the stopper.Type: GrantFiled: June 6, 1983Date of Patent: August 14, 1984Assignee: Becton, Dickinson and CompanyInventor: Edward P. Percarpio