Ion Or Electron Beam Irradiation Patents (Class 250/492.3)
  • Patent number: 11309163
    Abstract: A method of method of operating a multibeamlet charged particle device is disclosed. In the method, a target attached to a stage is translated, and each step of selecting beamlets, initializing beamlets, and exposing the target is repeated. The step of selecting beamlets includes passing a reconfigurable plurality of selected beamlets through the blanking circuit. The step of initializing beamlets includes pointing each of the selected beamlets in an initial direction. The step of exposing the target includes scanning each of the selected beamlets from the initial direction to a final direction, and irradiating a plurality of regions of the target on the stage with the selected beamlets.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: April 19, 2022
    Assignee: Applied Materials, Inc.
    Inventors: Mehdi Vaez-Iravani, Christopher Dennis Bencher, Krishna Sreerambhatla, Hussein Fawaz, Lior Engel, Robert Perlmutter
  • Patent number: 11275044
    Abstract: An anomaly determination method of the present embodiment includes: measuring a first resistance value of a processing target via a first grounding member when the first grounding member is attached to the processing target in a first chamber; bringing the first grounding member into contact with a grounded second grounding member to measure a second resistance value of the processing target via the first and second grounding members in a second chamber; and determining an anomaly of the second grounding member with an arithmetic processing unit based on a trend of a resistance difference between the first resistance value and the second resistance value for a plurality of processing targets.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: March 15, 2022
    Assignee: NUFLARE TECHNOLOGY, INC.
    Inventor: Shun Kanezawa
  • Patent number: 11170907
    Abstract: A radioisotope production apparatus (RI) comprising an electron source arranged to provide an electron beam (E). The electron source comprises an electron injector (10) and an electron accelerator (20). The radioisotope production apparatus (RI) further comprises a target support structure configured to hold a target (30) and a beam splitter (40) arranged to direct the a first portion of the electron beam along a first path towards a first side of the target (30) and to direct a second portion of the electron beam along a second path towards a second side of the target (30).
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: November 9, 2021
    Assignee: ASML Netherlands B.V.
    Inventors: Pieter Willem Herman De Jager, Sipke Jacob Bijlsma, Olav Waldemar Vladimir Frijns, Andrey Alexandrovich Nikipelov, Nicolaas Ten Kate, Antonius Theodorus Anna Maria Derksen, Jacobus Johannus Leonardus Hendricus Verspay, Robert Gabriël Maria Lansbergen, Aukje Arianne Annette Kastelijn
  • Patent number: 11154729
    Abstract: An apparatus for applying an electron beam to a subdermal tumor generates a pulsed electron beam that is collimated to a diameter of less than 1 mm and less than 10 millimeter-milliradiant transverse emittance. A biopsy needle having an interior diameter less than 2 mm and length between 1 cm and 100 cm is inserted through the skin to the tumor, and the electron beam is electromagnetically directed through the needle, so as to reach the tumor without irradiating intervening normal tissue and with minimal irradiation of surrounding normal tissue. The electron pulsing rate can be in the S-band or Q-band, the beam energy can be between 1 Mev and 6 MeV, and/or the beam brightness can be less than 10 mm·mrad. A distal end of the biopsy needle can include an electron-permeable vacuum barrier, and the apparatus can be evacuated to less than 10?8 Torr.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: October 26, 2021
    Assignee: Shenzhen Ming-Jie Medical Science and Technologies Co. Ltd.
    Inventors: Wei Gai, Huijun Xu, Huaibi Chen
  • Patent number: 11145430
    Abstract: Disclosed is a gas targeting system including a body, which has a frustoconical cavity; a cooling circuit including at least one channel which surrounds at least one portion of the cavity; a window, positioned facing an inlet of the cavity in order to close the cavity, including a fine sheet that is permeable to at least a portion of a beam of particles emitted by a particle accelerator and a support grid configured to support pressure differences between and inside of the cavity and an outside of the targeting system, with the fine sheet positioned between the support grid and the cavity; and a support flange which holds the window and is hermetically secured on the body, and which includes a mechanical attachment interface at the outlet of a particle accelerator.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: October 12, 2021
    Assignee: P M B
    Inventors: Thomas Campanella, Alain Perez Delaume
  • Patent number: 11132798
    Abstract: Provided is a tumor tracking method including: acquiring a detection image when a first ray source is located at a first detection point; determining, from a first reference image sequence in a preset image library, a first reference image corresponding to the detection image; acquiring, from a second reference image sequence corresponding to the first reference image sequence in the preset image library, a second reference image determined at the same time point as the first reference image; and determining a position of a tumor relative to a second ray source according to the second reference image.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: September 28, 2021
    Assignees: OUR UNITED CORPORATION, SHENZHEN OUR NEW MEDICAL TECHNOLOGIES DEVELOPMENT CO., LTD.
    Inventors: Hao Yan, Jinsheng Li, Jiuliang Li, Haifeng Liu
  • Patent number: 11110188
    Abstract: An electron beam irradiation device includes an electron gun, a housing, and an electron beam emission window. A rod portion of the housing includes a first tubular member, a second tubular member, a cooling gas flow space, and a wall member. The window is provided at an end portion on a distal end side of the first tubular member. The second tubular member surrounds the first tubular member. The cooling gas flow space includes at least a cooling gas flow path provided between an outer wall surface of the first tubular member and an inner wall surface of the second tubular member. The wall member is provided so as to perform partition between an electron beam emission space and the cooling gas flow space. The wall member is provided with a cooling gas ejection hole. The hole has a flow path sectional area smaller than a flow path sectional area of the cooling gas flow path.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: September 7, 2021
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Tatsuya Matsumura, Takeaki Hattori, Keigo Uchiyama
  • Patent number: 11097310
    Abstract: A paint hardening device is a device for hardening paint applied to a workpiece and includes an electron beam emission portion configured to emit an electron beam to harden the paint, and a storage chamber in which the electron beam emission portion is accommodated. The paint hardening device is configured to move the workpiece and the electron beam emission portion relative to each other while the electron beam is being applied to the paint from the electron beam emission portion in a state where an inert gas atmosphere is formed at least in an electron-beam passing region where the electron beam passes in the storage chamber, the electron beam being applied to the paint from the electron beam emission portion.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: August 24, 2021
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventor: Atsuo Nabeshima
  • Patent number: 11057982
    Abstract: A rotary module for a measuring device of an accelerator facility includes a first radial bearing including a first bearing side configured to be paired with an accelerator-side flange connection and further including a second bearing side configured to receive the measuring device on the first radial bearing in a bearing manner such that the measuring device is connected to the accelerator facility by the first radial bearing; and a drive configured to control a rotational movement of the measuring device about an axis of rotation.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: July 6, 2021
    Assignee: GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH
    Inventors: Chen Xiao, Michael Maier
  • Patent number: 11026647
    Abstract: The invention comprises a method and apparatus for imaging a tumor with X-rays while, simultaneously or alternatingly, treating or imaging the tumor with positively charged particles. An X-ray imaging system, such as one or two sets of a cone beam X-ray source coupled to an X-ray detector, is rotatable about a first axis and a patient. The X-ray imaging system is positioned off axis a path of charged particles delivered through an exit port of a nozzle system from a synchrotron and does not block a path of the positively charged particles from the exit nozzle to the patient or an imaging path from the patient to a scintillation detector. Fiducial indicators are used to confirm an unobstructed path of the positively charged particles in a treatment room comprising many movable elements, such as the X-ray imaging system and a patient positioning system/couch.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: June 8, 2021
    Inventors: James P. Bennett, W. Davis Lee
  • Patent number: 11020616
    Abstract: According to a first aspect, it is presented a method for determining a treatment plan comprising a distribution of spots for use with ion beam therapy for providing the spots in a target volume. The method comprises the steps of: selecting energy layers to be used in the treatment plan; determining a number of spot sizes to use; generating, for each energy layer, one copy of the energy layer for each spot size to use and populating each copy with spots of the spot size for that copy; optimizing spots of all copies of all energy layers, by repeatedly varying a weight of at least a subset of the spots and calculating an effect on a performance measurement, wherein the performance measurement is calculated by combining a plurality of evaluation criteria, comprising a first criterion related to total treatment time and a second criterion related to a desired dose distribution.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: June 1, 2021
    Assignee: RaySearch Laboratories AB
    Inventors: Erik Engwall, Lars Glimelius, Martin Janson
  • Patent number: 10984983
    Abstract: A particle beam system includes first and second particle beam columns. In a first operating mode, an end cap having an opening therein is outside a beam path of a first particle beam. In a second operating mode, the beam path of the first particle beam can extend through the opening of the end cap so that secondary particles coming from a work region can pass through the opening of the end cap to a detector in the interior of the first particle beam column. While the particle beam system is in the first operating mode, an image of an object arranged in the work region is recorded using the first particle beam column. While the particle beam system is in the second operating mode, the object is processed using a second particle beam.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: April 20, 2021
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Björn Gamm, Marko Matijevic
  • Patent number: 10857389
    Abstract: A proton therapy system based on a compact superconducting cyclotron, including: a superconducting cyclotron system, an energy selection system, a beam transport system, a fixed therapy room subsystem and a rotating frame therapy subsystem; a fixed-energy proton beam extracted from a superconducting cyclotron of the superconducting cyclotron system is adjusted into a continuous and adjustable proton beam of 70 MeV to 200 MeV by the energy selection system, thus realizing a longitudinal adjustment for a proton range during treating a tumor, and the continuous and adjustable proton beam is respectively transmitted to the fixed therapy room subsystem and the rotating frame therapy subsystem by the beam transport system. The cooperative control of the superconducting cyclotron system, the energy selection system, the beam transport system and the therapy head realizes the transverse expansion of proton beams, thus realizing intensity modulated radiation therapy for the tumor.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: December 8, 2020
    Assignee: HEFEI CAS ION MEDICAL AND TECHNICAL DEVICES CO., LTD
    Inventors: Yuntao Song, Jinxing Zheng, Qingxi Yang, Yonghua Chen, Hansheng Feng, Lu Liu, Junjun Li, Kaizhong Ding, Gen Chen, Pengyu Wang, Junsong Shen, Mingzhun Lei, Jianghua Wei
  • Patent number: 10850119
    Abstract: When constructing compensators for radiation therapy using ion or proton radiation beams, a computer-aided compensator editing method includes overlaying an initial 3D compensator model on an anatomical image of a target mass (e.g., a tumor) in a patient, along with radiation dose distribution information. A user manipulates pixels or voxels in the compensator model on a display, and a processor automatically adjusts the dose distribution according to the user edits. The user iteratively adjusts the compensator model until the dose distribution is optimized, at which time the optimized compensator model is stored to memory and/or output to a machining device that constructs a compensator from the optimized model.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: December 1, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Michael A. Meltsner, Ying Xiong, Michael Kaus
  • Patent number: 10811652
    Abstract: To carry out accurate defect inspection over a wide area, a defect inspection device (1) includes: a radiation source section (2) configured to emit an electromagnetic wave (4) to a separator roll (10); and a sensor section (3) configured to detect the electromagnetic wave (4) that the radiation source section (2) has emitted to the separator roll (10), the sensor section (3) being configured to detect the electromagnetic wave (4) before and after the separator roll is moved relative to the radiation source section (2).
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: October 20, 2020
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Yoshitaka Shinomiya, Koji Kashu, Yasuyuki Kondo
  • Patent number: 10792517
    Abstract: The invention comprises a method and apparatus for determining state of a positively charged particle, such as a proton, for use in imaging a tumor of a patient prior to and/or concurrent with cancer therapy. The imaging system comprises: (1) a beam transport path of the positively charged particle sequentially passing through a patient, through a first time of flight detector, and, after traversing a pathlength, at least into a second time of flight detector and (2) a beam state determination system using elapsed time between detection at the first and second time of flight detectors and the pathlength to determine a residual beam energy, which, when compared to a known incident beam energy, is used in generation of an image of the tumor. An optional beam energy degrading element increases time differences between the time of flight detectors.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: October 6, 2020
    Inventors: W. Davis Lee, Scott Penfold, Mark R. Amato, Louis P. Wainwright
  • Patent number: 10722735
    Abstract: A system includes a patient support and an outer gantry on which an accelerator is mounted to enable the accelerator to move through a range of positions around a patient on the patient support. The accelerator is configured to produce a proton or ion beam having an energy level sufficient to reach a target in the patient. An inner gantry includes an aperture for directing the proton or ion beam towards the target.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: July 28, 2020
    Assignee: Mevion Medical Systems, Inc.
    Inventors: Kenneth P. Gall, Stanley J. Rosenthal, Gordon D. Row, Michael J. Ahearn
  • Patent number: 10722736
    Abstract: A proton beam therapy system with a cantilever gantry. The cantilever gantry has one end portion (the fixed end portion) affixed to an external structure that supports the weight of the gantry. The remainder of the gantry is suspended and the free end portion is coupled to a beam nozzle. A main bearing is coupled to the fixed end portion and enables the gantry to rotate in a full range of 360° around the iso-center. A large counterweight can be disposed in the fixed end portion to keep the system center of mass close to the bearing. The gantry may have a monocoque housing, including a cantilever section enclosing the magnets and other components of the gantry beamline and a drum section on which the bearing is placed.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: July 28, 2020
    Assignees: Varian Medical Systems Particle Therapy GMBH, Varian Medical Systems, Inc.
    Inventors: Rizwan Hassan, Juergen Schultheiss, Lorenzo Miguelino Marte, Jean-Paul Etienne Sier, Michael Poier
  • Patent number: 10727055
    Abstract: A patterning method that includes providing an amorphous semiconductor surface to be patterned, and terminating the amorphous semiconductor surface by forming silicon-hydrogen (Si—H) on the surface to be patterned. A photoresist is formed on the surface to be patterned. The photoresist is then lithographically patterned using an extreme ultra violet (EUV) method. A photoresist is then developed on the surface to be patterned using negative tone development (NTD).
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: July 28, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Nelson M. Felix, Martin Glodde, Dario L. Goldfarb
  • Patent number: 10720256
    Abstract: Provided is an electron beam irradiating device capable of emitting an electron beam from an electron beam generation source surrounded by a vacuum chamber to outside of the vacuum chamber through an electron beam exit window. The electron beam exit window includes: a grid; a window foil allowing the electron beam to pass therethrough; and a frame-shaped pressing member pressing the window foil against the grid. The surface of the grid has a groove section having an annular shape. A metal gasket is pressed between the groove section and the window foil.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: July 21, 2020
    Assignee: HITACHI ZOSEN CORPORATION
    Inventors: Hiroyuki Daiku, Ichiro Sakai, Norihiro Inoue, Yohei Terasaka
  • Patent number: 10689196
    Abstract: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as energy, fuels, foods or materials. For example, systems and methods are described that can be used to treat feedstock materials, such as cellulosic and/or lignocellulosic materials, while cooling equipment and the biomass to prevent overheating and possible distortion and/or degradation. The biomass is conveyed by a conveyor, which conveys the biomass under an electron beam from an electron beam accelerator. The conveyor can be cooled with cooling fluid. The conveyor can also vibrate to facilitate exposure to the electron beam. The conveyor can be configured as a trough that can be optionally cooled.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: June 23, 2020
    Assignee: XYLECO, INC.
    Inventors: Marshall Medoff, Thomas Craig Masterman, Robert Paradis
  • Patent number: 10675483
    Abstract: A radiation planning system includes a predictor-corrector optimizer unit which computes a predicted dose based on a collection of control points with a current approximate dose, each control point with a corresponding set of leaf positions, and determines an additional control point with a corresponding set of leaf positions based on a difference of the predicted fluence and the current approximate fluence through a least cost or shortest path in a layered graph structure of realizable leaf positions. Tools are described to help a planner to evaluate the effect of parameter changes to the current plan based on an identified zone of influence. The planner interactively views the current plan based on a visualization of the plan objectives and correlations between the objectives.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: June 9, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Torbjoern Vik, Harald Sepp Heese, Daniel Bystrov, Juergen Weese, Christoph Neukirchen, Alfonso Agatino Isola, Matthieu Frederic Bal
  • Patent number: 10651064
    Abstract: A substrate treatment device includes: a substrate rotation part that horizontally holds and rotates a substrate; a nozzle that supplies a treatment liquid to a surface to be treated of the substrate rotated by the substrate rotation part; an imaging part that captures an image of an imaging area including a plurality of target areas in which a liquid film is formed when the treatment liquid is supplied to the substrate; and a detection part that refers to an imaging result of the imaging part and detects a treatment ending time point of each of the target areas based on a change in luminance value for each of the target areas. Further, the imaging area includes at least an area on a center side of the surface to be treated and an area on an outer circumferential side of the surface to be treated as the target areas.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: May 12, 2020
    Assignee: SCREEN Holdings Co., Ltd.
    Inventors: Hideji Naohara, Hiroaki Kakuma, Yuji Okita, Tatsuya Masui
  • Patent number: 10610175
    Abstract: Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. For one preferred embodiment, an IGRT apparatus is provided comprising a ring gantry having a central opening and a radiation treatment head coupled to the ring gantry that is rotatable around the central opening in at least a 180 degree arc. For one preferred embodiment, the apparatus further comprises a gantry translation mechanism configured to translate the ring gantry in a direction of a longitudinal axis extending through the central opening. Noncoplanar radiation treatment delivery can thereby be achieved without requiring movement of the patient. For another preferred embodiment, an independently translatable 3D imaging device distinct from the ring gantry is provided for further achieving at least one of pre-treatment imaging and setup imaging of the target tissue volume without requiring movement of the patient.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: April 7, 2020
    Assignee: ACCURAY INCORPORATED
    Inventor: Calvin R. Maurer, Jr.
  • Patent number: 10603518
    Abstract: A proton beam therapy system with a cantilever gantry. The cantilever gantry has one end portion (the fixed end portion) affixed to an external structure that supports the weight of the gantry. The remainder of the gantry is suspended and the free end portion is coupled to a beam nozzle. A main bearing is coupled to the fixed end portion and enables the gantry to rotate in a full range of 360° around the iso-center. A large counterweight can be disposed in the fixed end portion to keep the system center of mass close to the bearing. The gantry may have a monocoque housing, including a cantilever section enclosing the magnets and other components of the gantry beamline and a drum section on which the bearing is placed.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: March 31, 2020
    Assignees: Varian Medical Systems, Inc., Varian Medical Systems Particle Therapy GmbH
    Inventors: Rizwan Hassan, Juergen Schultheiss, Lorenzo Miguelino Marte, Jean-Paul Etienne Sier, Michael Poier
  • Patent number: 10555709
    Abstract: In one aspect, a charged particle tomography and radiation therapy system includes a charged particle tomography scanner (CPTS) unit to detect at least some of the charged particles of an emitted charged particle beam delivered to a region of interest of a subject. A processing unit can determine energy loss of the charged particle beam based on the detected trajectory information. An incoming detector is positioned to detect trajectory information of the at least some of the charged particles entering the subject. An outgoing detector is positioned to detect trajectory information of the at least some of the charged particles passing through and exiting the subject. A motion control unit can control movement of the incoming and outgoing detectors. The incoming and outgoing detectors are sized to cover at least an area substantially equivalent to the beam's cross-section. The processing unit can map radiation dose of the region of interest.
    Type: Grant
    Filed: February 28, 2015
    Date of Patent: February 11, 2020
    Assignee: Decision Sciences International Corporation
    Inventors: Michael James Sossong, Weidong Luo
  • Patent number: 10551165
    Abstract: This present disclosure generally relates to devices, methods, and systems for producing large numbers of SiO2 coated silicon chips with uniform film thickness controlled to angstrom and sub angstrom levels. The disclosure further relates to etching plates configured for receiving a plurality of chips mounted thereon.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: February 4, 2020
    Assignee: ADARZA BIOSYSTEMS, INC.
    Inventors: Christopher C. Striemer, Jared A. Carter, Wade Campney
  • Patent number: 10548212
    Abstract: Ion beams are efficiently extracted with an accelerator that includes a circular vacuum container including a pair of circular return yokes facing each other. Six magnetic poles are radially disposed from the injection electrode at the periphery thereof in the return yoke. Six recessions are disposed alternately with the respective magnetic poles in the circumferential direction of the return yoke. In the vacuum container, a concentric trajectory region, in which multiple beam turning trajectories centered around the injection electrode are present, is formed, and an eccentric trajectory region, in which multiple beam turning trajectories eccentric from the injection electrode are present, is formed around the region. In the eccentric trajectory region, the beam turning trajectories are dense between the injection electrode and the inlet of the beam extraction path. Gaps between the beam turning trajectories are wide in a direction 180° opposite to the inlet of the beam extraction path.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: January 28, 2020
    Assignee: Hitachi, Ltd.
    Inventors: Takamichi Aoki, Fuutarou Ebina, Masumi Umezawa, Shigemitsu Hara, Hideaki Nishiuchi, Takayoshi Seki
  • Patent number: 10532225
    Abstract: Disclosed is a tumor surface dose enhancing radiotherapy apparatus using a magnetic field, including a radiation beam generating unit that irradiates a radiation beam towards a tumor of a patient, a magnetic field generating unit that forms a magnetic field that is parallel to the radiation beam between the radiation beam generating unit and the tumor of the patient, and a control unit that controls a surface dose of the tumor by adjusting an intensity and an effective area of the magnetic field of the magnetic field generating unit.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: January 14, 2020
    Assignee: THE ASAN FOUNDATION
    Inventors: Jung Won Kwak, Nurihyun Jung, Byung Chul Cho, Seung Do Ahn, Sang Wook Lee, Jae Beom Bae
  • Patent number: 10518109
    Abstract: The invention comprises a method and apparatus for determining a radiation beam treatment path to a tumor, comprising the steps of: (1) delivering charged particles from an accelerator, along a first beam transport path, through an output nozzle, and along a treatment path to the tumor relative to a calibrated reference beam path from the output nozzle toward a patient position and (2) prior to the step of delivering, a main controller verifying an unobstructed linear path of the treatment path using a set of fiducial indicators positioned at least: on a first element physically affixed and co-movable with the output nozzle and on a moveable object in the treatment room. Optionally, voxels of the treatment beam path and potentially obstructing objects are defined in the treatment room using an axis system relative to the calibrated reference beam path and a reference beam point.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: December 31, 2019
    Inventors: Jillian Reno, Susan L. Michaud, Nick Ruebel, Mark R. Amato, W. Davis Lee, James P. Bennett
  • Patent number: 10507338
    Abstract: A gantry applies particle beams to a subject. An ultrasonic diagnostic apparatus scans the subject with ultrasonic waves via an ultrasonic probe, and acquires an ultrasonic image concerning a radiotherapy target region of the subject. A processing circuitry specifies a first planned point of a Bragg peak in the ultrasonic image, which anatomically coincides approximately with a second planned point of the Bragg peak decided in radiotherapy planning. The processing circuitry estimates a sighting point of the Bragg peak of a particle beam based on a body surface position of the subject and an actual range of the particle beam. The display displays the ultrasonic image to indicate the first planned point and the sighting point.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: December 17, 2019
    Assignee: Canon Medical Systems Corporation
    Inventors: Takayuki Kuwahara, Satoru Ohishi
  • Patent number: 10503860
    Abstract: In one embodiment, a method is for creating writing data used in a multi charged particle beam writing apparatus. The method includes partitioning a polygonal figure included in design data into a plurality of trapezoids that each include at least one pair of opposite sides parallel along a first direction and that join so as to be continuous in a second direction orthogonal to the first direction while a side parallel to the first direction serves as a common side, and creating the writing data by, when a first trapezoid, a second trapezoid, and a third trapezoid join along the second direction, representing a position of a common vertex shared by the second trapezoid and the third trapezoid using displacements in the first direction and the second direction from a position of a common vertex shared by the first trapezoid and the second trapezoid. In at least one of the plurality of trapezoids, different dose amounts are defined in the first direction.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: December 10, 2019
    Assignee: NuFlare Technology, Inc.
    Inventors: Shigehiro Hara, Kenichi Yasui, Yasuo Kato
  • Patent number: 10506701
    Abstract: Provided herein are high energy ion beam generator systems and methods that provide low cost, high performance, robust, consistent, uniform, low gas consumption and high current/high-moderate voltage generation of neutrons and protons. Such systems and methods find use for the commercial-scale generation of neutrons and protons for a wide variety of research, medical, security, and industrial processes.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: December 10, 2019
    Assignee: PHOENIX LLC
    Inventors: Arne Kobernik, Carl Sherven, Casey Lamers, Chris Seyfert, Evan Sengbusch, Gabriel Becerra, Jin Lee, Logan Campbell, Mark Thomas, Michael Taylor, Preston Barrows, Ross Radel, Tye Gribb
  • Patent number: 10460919
    Abstract: The present disclosure establishes new dissociation parameters that may be used to determine the collision energy (CE) needed to achieve a desired extent of dissociation for a given analyte precursor ion using collision cell type collision-induced dissociation. This selection is based solely on the analyte precursor ion's molecular weight, MW, and charge state, z. Metrics are proposed that may be used as a parameter for the “extent of dissociation”, and then predictive models are developed of the CEs required to achieve a range of values for each metric. Each model is a simple smooth function of only MW and z of the precursor ion. Coupled with a real-time spectral deconvolution (m/z to mass) algorithm, methods in accordance with the invention enable control over the extent of dissociation through automated, real-time selection of collision energy in a precursor-dependent manner.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: October 29, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Ping F. Yip, Helene L. Cardasis, James L. Stephenson, Jr.
  • Patent number: 10434331
    Abstract: An example particle therapy system includes: a particle accelerator to output a beam of charged particles; and a scanning system to scan the beam across at least part of an irradiation target. An example scanning system includes: a scanning magnet to move the beam during scanning; and a control system (i) to control the scanning magnet to produce uninterrupted movement of the beam over at least part of a depth-wise layer of the irradiation target so as to deliver doses of charged particles to the irradiation target; and (ii) to determine, in synchronism with delivery of a dose, information identifying the dose actually delivered at different positions along the depth-wise layer.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: October 8, 2019
    Assignee: Mevion Medical Systems, Inc.
    Inventors: Charles D. O'Neal, III, Adam C. Molzahn
  • Patent number: 10431412
    Abstract: Example compact ion beam sources are provided that can be used to generate ion beams using chemical species and field emitter elements or field emitter arrays. In some example, the compact ion beam source can be implemented as neutron sources based on ion beam bombardment of neutron-rich targets.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: October 1, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Akintunde I. Akinwande, Stephen Angelo Guerrera
  • Patent number: 10398794
    Abstract: An internal surface electron beam-irradiating device sterilizes the internal surface of a vial by irradiation with an electron beam. The internal surface electron beam-irradiating device includes an electron beam generator that generates the electron beam, a vacuum chamber containing the electron beam generator, an output window that emits the electron beam to the outside of the vacuum chamber, and an extension nozzle that guides an electron cloud formed by extending the electron beam emitted from the output window. The extension nozzle includes a leaking section that leaks the electron cloud. The leaking section includes empty portions that discharge part of the electron cloud to the outside, and a component portion that guides the electron cloud into the leaking section.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: September 3, 2019
    Assignee: HITACHI ZOSEN CORPORATION
    Inventors: Hiroyuki Daiku, Takeshi Noda, Ichiro Sakai
  • Patent number: 10384082
    Abstract: Disclosed is a method for determining a deviation of the position of an anatomical body part relative to a predetermined position defined by a radiation treatment plan. A monitoring image is taken of the anatomical body part at the instant that a predetermined control point defined in the treatment plan has been reached. The monitoring image is compared to a simulated image simulated from a planning image of the anatomical body from the perspective of a monitoring camera used to generate the monitoring image. The comparison allows for a determination of whether there is a positional deviation.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: August 20, 2019
    Assignee: Brainlab AG
    Inventors: Kajetan Berlinger, Stephan Fröhlich
  • Patent number: 10381195
    Abstract: A charged particle beam treatment apparatus includes an accelerator that emits a charged particle beam by accelerating a charged particle, an irradiation unit that irradiates an irradiation target body with the charged particle beam, a beam transport line that connects the accelerator and the irradiation unit to each other, and that transports the charged particle beam from the accelerator to the irradiation unit, and a control unit that controls the irradiation unit in irradiating the irradiation target body with the charged particle beam. The irradiation unit includes a scanning unit that scans each layer with the charged particle beam. After one layer is scanned with the charged particle beam by using a first current value, the control unit controls the irradiation unit so as to scan and irradiate the one layer with the charged particle beam by using a second current value which is different from the first current value.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: August 13, 2019
    Assignee: SUMITOMO HEAVY INDUSTRIES, LTD.
    Inventor: Nagaaki Kamiguchi
  • Patent number: 10361061
    Abstract: There is provided an electron microscope capable of recording images in a shorter time. The electron microscope (100) includes: an illumination system (4) for illuminating a sample (S) with an electron beam; an imaging system (6) for focusing electrons transmitted through the sample (S); an electron deflector (24) for deflecting the electrons transmitted through the sample (S); an imager (28) having a photosensitive surface (29) for detecting the electrons transmitted through the sample (S), the imager (28) being operative to record focused images formed by the electrons transmitted through the sample (S); and a controller (30) for controlling the electron deflector (24) such that an active electron incident region (2) of the photosensitive surface (29) currently hit by the beam is varied in response to variations in illumination conditions of the illumination system (4).
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: July 23, 2019
    Assignee: JEOL Ltd.
    Inventors: Yukihito Kondo, Ryusuke Sagawa
  • Patent number: 10354454
    Abstract: A system and method for obtaining a composite image by combining multiple sub-images are provided. In some embodiments, the method may include retrieving overlapping images corresponding to sub-mages including 3D volume data, generating two-dimensional (2D) projection images and pixel maps based on the overlapping images, performing one or more registrations based on the 2D projection images and the pixel maps, calibrating the sub-images based on the results of the registration(s), and fusing the sub-images to produce a composite image. In some embodiments, the method may include setting a plurality of parameters relating to an X-radiation source or a radiation detector based on a preliminary number of exposures and a preliminary exposure region, controlling, based on at least one of the plurality of parameters, a motion of the X-radiation source or a motion of the radiation detector to capture a plurality of sub-images, and combining the plurality of sub-images.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: July 16, 2019
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Wenjun Yu, Xiangcui Jin, Yang Hu, Haifeng Xiao, Hongwei Chen, Wei Wang
  • Patent number: 10336520
    Abstract: A material for decorative wrap including a sheet of non-corrugated material having a first side, a second side, a first edge, and a second edge; a plurality of scores formed into the first side extending from the first edge to the second edge; and a plurality of scores formed into the second side extending from the first edge to the second edge. The plurality of scores formed into the first side and the plurality of scores formed into the second side may alternate such that every other score is formed into the first side and the remaining scores are formed into the second side. Each score formed into the first and second sides may extend substantially perpendicular to at least one of the first and second edges.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: July 2, 2019
    Assignee: THE IMAGINE GROUP, LLC
    Inventor: Mark Richard Popp
  • Patent number: 10324385
    Abstract: Support arrangement for supporting a radiation projection system in a substrate processing apparatus, the support arrangement comprising: a support body for supporting the radiation projection system; electrical wiring for supplying voltages to components within the radiation projection system and/or for supplying control data for modulation of radiation to be projected onto a target surface by the radiation projection system; optical fibers, for supplying control data for modulation of radiation to be projected onto a target surface by the radiation projection system, and a cooling arrangement comprising one or more fluid conduits for cooling the radiation projection system; the electrical wiring, the optical fibers, and the cooling arrangement being at least partly accommodated in and/or supported by the support body.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: June 18, 2019
    Assignee: MAPPER LITHOGRAPHY IP B.V.
    Inventors: Jerry Johannes Martinus Peijster, Diederik Geert Femme Verbeek
  • Patent number: 10315053
    Abstract: A portal imaging device is used to determine an amount of radiation that is delivered to at least one point while administering a radiation treatment therapy to a patient. Upon detecting that the amount of radiation that is delivered to that at least one point exceeds a predetermined amount of radiation (for example, a planned amount of radiation per the radiation treatment plan), administration of radiation treatment therapy to the patient can be automatically halted.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: June 11, 2019
    Assignee: Varian Medical Systems International AG
    Inventors: Risto Ahonen, Esa Kuusela, Tuomas E. Torsti
  • Patent number: 10319554
    Abstract: Example compact modular electron beam units are provided that can be used to generate electron beams using field emitter elements. A modular electron beam unit may comprise an electron beam source including a base portion, at least one field emitter element coupled to the base portion, the field emitter element including a field emitter tip, at least one gate electrode and a membrane window disposed over the at least one gate electrode.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: June 11, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Akintunde I. Akinwande, Stephen Angelo Guerrera
  • Patent number: 10307617
    Abstract: The invention comprises a system for controlling a charged particle beam shape and direction relative to a controlled and dynamically positioned patient and/or an imaging surface, such as a scintillation plate of a tomography system and/or a first two-dimensional imaging system coupled to a second two-dimensional imaging system. Multiple interlinked beam/patient/imaging control stations allow safe zone operation and clear interaction with the charged particle beam system and the patient. Both treatment and imaging are facilitated using automated sequences controlled with a work-flow control system.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: June 4, 2019
    Inventors: Susan L. Michaud, Stephen L. Spotts, James P. Bennett, W. Davis Lee
  • Patent number: 10300301
    Abstract: Provided are a respiratory guiding device (100) and method used in respiratory gated ion beam irradiation, the respiratory guiding device (100) comprising: a respiratory signal detecting unit (101), for measuring a respiratory motion trajectory curve during free breathing and deep breathing, and a real-time respiratory motion position signal in the case of guided respiration; a respiratory signal processing unit (102), for modeling free breathing and deep breathing according to an average respiratory cycle and an average respiratory amplitude calculated on the basis of the respiratory motion trajectory curve and setting a preset breath-hold time at the tail end of a function curve of a free breathing model and a deep breathing model to establish a respiratory guiding curve; a control unit (103), for adjusting the magnetic excitation cycle of a synchrotron according to the respiratory cycle represented by the respiratory guiding curve during free breathing or deep breathing, thus synchronizing the magnetic exc
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: May 28, 2019
    Assignee: INSTITUTE OF MODERN PHYSICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Pengbo He, Qiang Li, Zhongying Dai, Xinguo Liu, Ting Zhao, Tingyan Fu, Guosheng Shen, Yuanyuan Ma, Qiyan Huang, Yuanlin Yan
  • Patent number: 10306745
    Abstract: An accelerator 4 includes a circular vacuum container including circular return yokes 5A, 5B. An injection electrode 18 is disposed closer to an inlet of a beam extraction path 20 in the return yoke 5B than a central axis C of the vacuum container. Magnetic poles 7A to 7F are radially disposed from the injection electrode 18 at the periphery of the injection electrode 18 in the return yoke 5B. Recessions 29A to 29F are disposed alternately with the magnetic poles 7A to 7F in the circumferential direction of the return yoke 5B. In the vacuum container, a concentric trajectory region, in which multiple beam turning trajectories centered around the injection electrode 18 are present, is formed, and an eccentric trajectory region, in which multiple beam turning trajectories eccentric from the injection electrode 18 are present, is formed around the region.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: May 28, 2019
    Assignee: Hitachi, Ltd.
    Inventors: Takamichi Aoki, Fuutarou Ebina, Hideaki Nishiuchi, Shigemitsu Hara, Masumi Umezawa, Takayoshi Seki
  • Patent number: 10283422
    Abstract: An ion implantation method includes measuring a beam energy of an ion beam that is generated by a high-energy multistage linear acceleration unit operating in accordance with a tentative high-frequency parameter, adjusting a value of the high-frequency parameter based on the measured beam energy, and performing ion implantation by using the ion beam generated by the high-energy multistage linear acceleration unit operating in accordance with the adjusted high-frequency parameter. The tentative high-frequency parameter provides a value different from a value of the high-frequency parameter for achieving a maximum acceleration in design to a high-frequency resonator in a part of stages including at least a most downstream stage. The adjusting includes changing at least one of a voltage amplitude and a phase set for the high-frequency resonator in the part including the at least most downstream stage.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: May 7, 2019
    Assignee: SUMITOMO HEAVY INDUSTRIES ION TECHNOLOGY CO., LTD.
    Inventors: Hiroyuki Kariya, Hideki Morikawa, Masaki Ishikawa
  • Patent number: 10279064
    Abstract: In some embodiments, a sensor assembly for continuous measurement of at least one dose control parameter of an electron beam during a substantial part of the duration of a sterilizing process of package material includes an electron beam emitter adapted to emit electron beam (e?) from an electron exit window and a sensor device that includes: a sensor surface having an electron excitable material arranged to be radiated with at least a part of said electron beam (e?), so as to excite said electron excitable material so that said electron excitable material emits luminescence and a detector arranged and adapted to detect said luminescence. The electron beam emitter is adapted to emit a continuous electron beam (e?) during a predetermined time period so as to irradiate and sterilize package material.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: May 7, 2019
    Assignee: Tetra Laval Holdings & Finance S.A.
    Inventor: Alaa Omrane