With Raman Type Light Scattering Patents (Class 356/301)
  • Patent number: 10408760
    Abstract: A Raman spectrum detecting method and electronic device are disclosed. In one aspect, an example method includes detecting and obtaining a first Raman spectrum signal of a package. A second Raman spectrum signal of the object is detected and obtained with the package. The first Raman spectrum signal is successively subtracting from the second Raman spectrum signal to obtain a series of third Raman spectrum signals with package interference eliminated. Information entropies of the third and first Raman spectrum signals are calculated and compared with information entropy of the first Raman spectrum signal. Information entropies of third Raman spectrum signals greater than the first Raman spectrum signal are set into an information entropy sequence to be selected, and a minimum information entropy from the sequence is selected. The third Raman spectrum signal corresponding to the minimum information entropy is used as an optimized Raman spectrum signal with package interference eliminated.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: September 10, 2019
    Assignee: Nuctech Company Limited
    Inventors: Hongqiu Wang, Wei Gou
  • Patent number: 10408727
    Abstract: A nanoparticle screening chip and a method using said chip allowing for determining physical properties of nanoparticles, wherein the screening chip comprises a substrate having a working surface divided into a plurality of areas, wherein (1) each of these areas presents different surface properties defined by surface energy component (d,b,a), the total free energy ?TOT of the surface of each area being defined as follows: ?TOT=?LW+2(?+??)0.5, wherein the components are: ?LW=dispersive component=d, ?+=electron acceptor component=b, ??=electron donor component=a; and (2) each of these areas comprises a plurality of subareas, each subarea comprising an array of sub-micrometric holes or elongated grooves with a different aperture size (S1, S2, S3, . . . ).
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: September 10, 2019
    Assignee: THE EUROPEAN UNION, REPRESENTED BY THE EUROPEAN COMMISSION
    Inventors: Andrea Valsesia, Cloé Desmet, Pascal Colpo, François Rossi
  • Patent number: 10408761
    Abstract: A surface-enhanced Raman scattering element comprises a substrate having a principal surface; a molded layer having a support part formed on the principal surface of the substrate so as to extend along the principal surface and a fine structure part formed on the support part; a frame part formed on the principal surface of the substrate so as to surround the support part and fine structure part along the principal surface; and a conductor layer formed on at least the fine structure part and constituting an optical functional part for generating surface-enhanced Raman scattering; while the fine structure part are formed integrally with the support part.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: September 10, 2019
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Masashi Ito, Katsumi Shibayama, Takafumi Yokino, Masaki Hirose, Toshimitsu Kawai, Kazuto Ofuji, Yoshihiro Maruyama
  • Patent number: 10393663
    Abstract: An SERS element includes a substrate, a fine structure portion formed on a surface of the substrate and having a plurality of pillars, and a conductor layer formed on the fine structure portion and constituting an optical functional portion that causes surface-enhanced Raman scattering. A groove is provided in an outer surface of each pillar. A plurality of gaps are formed in the conductor layer by forming the conductor layer on the outer surface of each pillar in a state in which at least a portion of an inner surface of the groove is exposed.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: August 27, 2019
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Katsumi Shibayama, Masashi Ito, Kazuto Ofuji, Hiroki Oyama, Yoshihiro Maruyama, Nao Inoue
  • Patent number: 10393656
    Abstract: An ATR optical instrument condensing an infrared light to a sample-side surface of a ATR crystal to measure a total reflection absorption spectrum includes: an incident-side ellipsoidal mirror condensing the infrared light to the sample-side surface at an incident angle equal to or larger than a critical angle ?c inside; an exiting-side ellipsoidal mirror condensing a total reflection light from the sample-side surface; dichroic mirrors guiding an illumination light coaxially to the ellipsoidal mirrors; and a ZnS lens condensing a visible light from the sample-side surface to observe a contact state of the sample. The dichroic mirrors are configured to guide the illumination light to the ellipsoidal mirrors such that the illumination light is condensed to the sample-side surface at an angle less that a critical angle ?c? of the visible light. Accordingly, the ATR optical instrument becomes compact, and can visually observe the contact state of the sample surface.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: August 27, 2019
    Assignee: JASCO CORPORATION
    Inventors: Noriaki Soga, Tetsuji Sunami, Tsubasa Asatsuma, Hiroshi Sugiyama, Jun Koshobu
  • Patent number: 10359313
    Abstract: A compact dual-wavelength Raman probe using two laser sources each providing Raman excitation light at a different wavelength is disclosed causing Raman scattering in a fingerprint region associated with one excitation wavelength and causing Raman scattering in a stretch region, which are detected by the same detector array.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: July 23, 2019
    Assignee: Innovative Photonic Solutions, Inc.
    Inventors: Scott L. Rudder, Joseph B. Gannon, Robert V. Chimenti, Benjamin L. Carlin, John C. Connolly
  • Patent number: 10350678
    Abstract: The present specification relates to a metal nanoparticle.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: July 16, 2019
    Assignee: LG CHEM, LTD.
    Inventors: Kwanghyun Kim, Gyo Hyun Hwang, Sang Hoon Kim, Jun Yeon Cho
  • Patent number: 10352863
    Abstract: The present invention comprises a novel approach for optimizing detection performance of a standoff optical detection system using the inelastic scattering of light from the target and/or inelastic scattering of light from molecules between the light emitting source and the target. This is a useful approach primarily for systems which already employ a pulsed light source, a detector, and a timing mechanism but whose primary function is not the detection of range. Using this methodology removes the need to deploy a secondary device to find range or augments the ability of any included range finder to widen the overall system operating envelope, reliability, and performance.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: July 16, 2019
    Assignee: Alakai Defense Systems, Inc.
    Inventors: Kenneth R. Pohl, Christopher Neglia
  • Patent number: 10345243
    Abstract: Disclosed is an apparatus and method for processing a bio optical signal based on a spread spectrum scheme including a demodulator configured to collect a bio optical signal generated in response to an incident beam modulated based on a spreading code being scattered from a target analyte, and remove a noise from the bio optical signal by demodulating the bio optical signal based on the spreading code, wherein the bio optical signal has a correlation with the modulated incident beam.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: July 9, 2019
    Assignees: Electronics and Telecommunications Research Institute, Korea Advanced Institute of Science and Technology
    Inventors: Won Kyoung Lee, Ki-Hun Jeong, Moonseong Park
  • Patent number: 10345242
    Abstract: This invention discloses a Reverse Intensity Correction method for spectral library search to correct for instrument response without the side effect of magnifying the noise in the low responsivity region of test spectra. Instead of applying relative intensity correction to the sample test spectra to match the standardized library spectra, a reverse intensity correction is applied to the standardized library spectra to match the uncorrected sample spectrum. This simple procedural change improves library search performance, especially for dispersive CCD Raman analyzers using NIR excitations, where the instrument response often varies greatly across the spectral range, and SNR in the low responsivity regions is typically poor.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: July 9, 2019
    Assignee: B&W TEK LLC
    Inventors: Jun Zhao, Xin Jack Zhou
  • Patent number: 10288832
    Abstract: Disclosed is an analyte detector with a light blocking assembly. The light blocking assembly includes a light blocking cartridge positioned within the bore of a sampling tip. The light blocking assembly provides fluid communication between the environment and a sensor assembly in an analyte detector while substantially precluding the passage of light.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: May 14, 2019
    Assignee: FLIR Systems, Inc.
    Inventors: Christopher Willis, Craig Aker
  • Patent number: 10281331
    Abstract: A nonlinear optical process on increasing the signal in SRS microscope by Resonant Stimulated Raman Scattering (RSRS) combines both RRS and SRS nonlinear processes, in absorber and host such a ?-carotene-methanol solution, Flavins, or other key absorbers in tissues. The observed effect of enhanced RSRS in small signal gain is attributed to RR process in absorber ?-carotene that transferring excess vibrations to host methanol from anharmonic vibrational interactions between the solute ?-carotene in resonance with the solvent methanol vibrations. SRS microscopy signals are improved in RSRS microscope for imaging vibrational states in lipids CH2 and proteins CH3 in cancer tissues from RR in Flavins or other native chromophores in tissue and for applications in other areas of neuroscience and biomedicine, potentially enhancing signals in the RSRS microscope by 2 to 1000 times.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: May 7, 2019
    Inventors: Robert Alfano, Lingyan Shi
  • Patent number: 10281330
    Abstract: The invention relates to a spectrophotometer, especially a spectrophotometer that can carry out simultaneous analysis at different points on the same sample (4), with a high spatial resolution and without requiring a mechanical system for physical scanning along the sample. This is obtained by the provision of means for processing the light received by the photodetectors (5), said processing means having a correlation wherein each of the photodetectors (5) corresponds to a spatial point on the sample (4). In the case of dark field applications, the present invention ensures the standardization of the data using the same measure.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: May 7, 2019
    Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Valerio Pini, Priscila Monteiro Kosaka, Francisco Javier Tamayo De Miguel, Montserrat Calleja Gomez, Daniel Ramos Vega, Oscar Malvar Vidal, Jose Jaime Ruz Martinez, Mario Encinar Del Pozo
  • Patent number: 10267739
    Abstract: A laser system and method employing stimulated Raman scattering using a main laser pulse and a delayed replica reference pulse are provided. A further aspect calculates stimulated Raman loss and stimulated Raman gain from a reflected laser light scatter collected from a fabric or paper specimen. In another aspect, a laser system receives a low energy portion of a spectrum of main and reference laser pulses with a first photodetector, receives a higher energy portion of the spectrum of the main and reference pulses with a second photodetector, and uses a controller to determine a Raman active phonon transfer of energy manifested as an increase in the reflected laser scatter in a lower energy portion of the spectrum and a decrease in a higher energy portion of the spectrum. In yet another aspect, the controller automatically determines if a hazardous particle or substance such as an explosive, is present on a specimen.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: April 23, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventors: Marcos Dantus, Marshall Thomas Bremer
  • Patent number: 10267678
    Abstract: Embodiments of the present invention provide a Raman spectroscopic inspection method, comprising the steps of: measuring a Raman spectrum of an object to be inspected successively to collect a plurality of Raman spectroscopic signals; superposing the plurality of Raman spectroscopic signals to form a superposition signal; filtering out a florescence interfering signal from the superposition signal; and identifying the object to be inspected on basis of the superposition signal from which the florescence interfering signal has been filtered out. By means of the above method, a desired Raman spectroscopic signal may be acquired by removing the interference caused by a florescence signal from a Raman spectroscopic inspection signal of the object. It may inspect correctly the characteristics of the Raman spectrum of the object so as to identify the object effectively.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: April 23, 2019
    Assignee: NUCTECH COMPANY LIMITED
    Inventors: Ziran Zhao, Jianhong Zhang, Hongqiu Wang, Weiwei Wang, Zhiming Wang, Yumin Yi
  • Patent number: 10261216
    Abstract: The present disclosure describes methods and systems for detecting a tracer in a hydrocarbon reservoir. One method includes injecting a tracer at a first location in a reservoir, wherein the tracer mixes with subsurface fluid in the reservoir; collecting fluid samples at a second location in the reservoir; mixing a magnetic surface-enhanced Raman scattering (SERS) particle with the fluid samples; applying a magnetic field to the mixed fluid samples; and analyzing the fluid samples to detect a presence of the tracer in the fluid samples.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: April 16, 2019
    Assignee: Saudi Arabian Oil Company
    Inventors: Sehoon Chang, Wei Wang, Shannon L. Eichmann
  • Patent number: 10253346
    Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: April 9, 2019
    Assignees: Seraph Biosciences, Inc., Wayne State University
    Inventors: Gregory William Auner, Charles Shanley, Michelle Brusatori, Tara Twomey, David Sant
  • Patent number: 10247673
    Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: April 2, 2019
    Assignee: OndaVia, Inc.
    Inventors: Mark C. Peterman, Merwan Benhabib, Samuel Kleinman
  • Patent number: 10241053
    Abstract: A bacterial detection platform integrating the sensitive SERS technique and the advanced mapping technique. Bacterial cells on the SERS substrate are detected using the mapping technique. The identification is based on the fingerprint of the bacterial SERS spectra. The quantification of the cells is based on the mapping technique. For different applications, silver or gold nanoparticles can be integrated onto a filter membrane for concentration and detection of bacterial cells in water or silver dendrites can be used as the SERS substrate. The SERS substrates are also modified with capturers and fixed in a vessel to concentrate cells from complex liquid matrices.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: March 26, 2019
    Assignee: University of Massachusetts
    Inventor: Lili He
  • Patent number: 10241052
    Abstract: An optical system includes a first light source configured to generate a first light beam having a first power. The optical system includes a second light source configured to generate at least one second light beam having a second power. The second power can be greater than the first power. The optical system includes a device for a least partially co-aligning the at least one second light beam of the second power with the first light beam of the first power in a parallel or near-parallel pattern and within a region of atmospheric space so that energy will transfer from photons of the at least one second light beam of the second power to photons of the first light beam of the first power within the region of atmospheric space via Stimulated Raman Scattering (SRS).
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: March 26, 2019
    Assignee: BOOZ ALLEN HAMILTON INC.
    Inventor: James A. Davis
  • Patent number: 10234428
    Abstract: Optically trapped specimens (typically nanoparticles having diameters between 1 and 50 nm) are excited with an optical beam so as to induce vibrations in the specimens. A trapping optical beam and the excitation optical beam can produce vibrations based on a difference frequency based on the trapping optical beam and the excitation optical beam. Scattered optical radiation as a function of modulation frequency can be recorded and used to identify or characterize the specimen.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: March 19, 2019
    Inventors: Reuven Gordon, Skyler Wheaton, Ryan M. Gelfand
  • Patent number: 10228708
    Abstract: The invention relates to a method for optimizing a mixture of components for the production of a target product by means of spectral analysis, preferably by means of spectral analysis (topological) in the near infrared region (NIR). The aim of the method is to produce a target product by batch mixing and/or continuous mixing of the “n” components thereof, on the basis of different flows of said components with controlled concentrations and/or flow rates, said target product requiring a set of ranges of values of physiocohemical characteristics for the commercialization thereof. According to the method, a batch mixer or a continuous mixer is supplied with said components with controlled concentrations and/or flow rates.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: March 12, 2019
    Assignee: TOPNIR SYSTEMS SAS
    Inventors: Didier Lambert, Claude Saint Martin, Miguel Sanchez, Bernard Ribero
  • Patent number: 10222336
    Abstract: A system includes an illumination source, a detector and a processor. The detector acquires spectral measurements of a sample under test under at least one varying condition. The processor processes the measurements to generate at least one spectral representation that includes Raman spectra and at least one spectral representation that includes non-Raman spectra.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: March 5, 2019
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Huei Pei Kuo, Zhiyong Li, Shih-Yuan Wang, Alexandre M Bratkovski, Steven Barcelo, Ansoon Kim, Gary Gibson, Mineo Yamakawa
  • Patent number: 10215633
    Abstract: A miniature spectrometer comprises an input port, a light sensor, a miniature diffraction optical grating, an optical grating accommodation slot, a cushion, and an affixing plate. The miniature spectrometer may further comprise a waveguide device, and the optical grating accommodation slot is positioned in a space defined by an opening of the waveguide device. The input port receives an optical signal which proceeds in the waveguide device. The miniature diffraction optical grating separates the optical signal into numerous spectral components to be projected onto the light sensor. The cushion is stacked on the miniature diffraction optical grating, with both disposed in the optical grating accommodation slot. The affixing plate is disposed on the waveguide device to apply a compressing force on the cushion to affix the miniature diffraction optical grating in the optical grating accommodation slot.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: February 26, 2019
    Inventor: Cheng-Hao Ko
  • Patent number: 10215700
    Abstract: A cancer-related substance in blood or a biological sample can be detected in a selective manner, so it becomes possible to determine the occurrence of cancer by observation of fluorescent image of a crystal of the censor related substance or a coagulated state of the crystal on a plasmonic chip. In addition, the state of chemical modification of a histone tail can be determined by a Raman spectrum analysis. Furthermore, the location of the cancer-related substance aggregated on a substrate cannot be determined with naked eyes. Then, as a second aspect of the present invention, a method for diagnosing a cancer disease is provided, said method being characterized by firstly identifying the location of the region of a crystal by observing fluorescent image on a microscope, and then irradiating the crystal, with laser beam to analyze with respect to the chemical modification of a histone tail and a remodeling factor.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: February 26, 2019
    Assignee: MYTECH CO., LTD.
    Inventors: Yuki Hasegawa, Katsuyuki Hasegawa
  • Patent number: 10209195
    Abstract: A device for collecting surface-enhanced Raman scattering spectra using a full-aperture-angle parabolic mirror. The device is a small-sized ultra-sensitive SERS Raman spectroscopic enhanced probe and a spectrometer, a surface plasmon resonance (SPR) Raman spectroscopic probe and a spectrometer, a spectrum analyzer having triple functions of an SPR Raman/absorption dual-spectrum and refractive index, a flow particle Raman analysis/micro-fluidic Raman analysis probe and a spectrometer, a minimally invasive flexible lumen Raman spectroscopic probe and a spectrometer and a Raman intelligent surgical scalpel. An external reflective or internal reflective parabolic mirror at full aperture angle is adopted to collect Raman scattering systems and SERS substrates to ensure ultra-high sensitivity. A portable and hand-held Raman spectrometer would be widely applied to various trace analysis such as food safety and early-stage cancer screening, environmental safety screening and detection.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: February 19, 2019
    Inventor: Peirong Jian
  • Patent number: 10211887
    Abstract: A receiver of the disclosure includes: a load modulator that transmits an active load modulation signal generated by active load modulation to a reader writer, in response to a carrier signal transmitted from the reader writer; and a controller that determines whether the active load modulation signal has reached the reader writer, and controls the load modulator to retransmit the active load modulation signal, after changing a phase of the active load modulation signal with respect to the carrier signal, in a case where the controller determines that the active load modulation signal has not reached the reader writer.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: February 19, 2019
    Assignee: Sony Corporation
    Inventors: Hiroaki Nakano, Uichiro Omae, Hiroaki Fujita, Masayoshi Abe, Ken Matsui
  • Patent number: 10209126
    Abstract: The present application discloses a UV radiation monitoring apparatus, method, and system. The monitoring apparatus includes a case, an authenticator disposed on the case and configured to identify a user, a controller in the case coupled to the authenticator to enable a first mode for an authenticated user, a detector on the case coupled to the controller and configured to measure an intensity of ultraviolet radiation and generate ultraviolet index (UVI) value at the present time, a memory coupled to the controller and configured to store the UVI values over an exposure time added into historical UVI data for the authenticated user, and a display unit to display the UVI value at the present time and the personal health instructions on UV protection for the authenticated user. The monitoring apparatus further is configured to be paired with a mobile terminal for providing updated personal health instructions.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: February 19, 2019
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventor: Jian Gao
  • Patent number: 10161874
    Abstract: A surface enhanced Raman scattering (SERS) active nanoassembly comprising anisotropically assembled gold nanoparticles in a monolayer double row immobilized on a glass layer is disclosed. The discrete gold nanoparticles are separated by interparticle gaps of 0.5-10 nm that provide hotsites where appropriate excitation creates surface plasmon resonaces and regions of strong and localized electromagnetic fields that enhance Raman signal substantially, 104-1015 fold. An appropriate SERS apparatus comprising the nanoassembly for detecting an analyte is also disclosed. In addition, a method for producing the nanoassembly as well as the application of the nanoassembly or the apparatus comprising the nanoassembly in a method for measuring the SERS signal of an analyte is disclosed.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: December 25, 2018
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Mohammad Kamal Hossain, Yukihiro Ozaki
  • Patent number: 10161858
    Abstract: An in-situ process-monitoring device for measuring a curing state of components coated with a UV-curable lacquer. The device includes at least one radiation source for curing the lacquer, as well as at least one signal source and at least one spectrometer for measuring radiation of the signal source reflected from the components, in order to determine the curing state. The measuring is carried out in a contactless manner, and the at least one signal source for the measuring is identical to the at least one radiation source for the curing.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: December 25, 2018
    Assignee: OERLIKON SURFACE SOLUTIONS AG, PFÄFFIKON
    Inventor: Othmar Zueger
  • Patent number: 10156658
    Abstract: The present disclosure describes methods and systems for detecting a tracer in a hydrocarbon reservoir. One method includes injecting a tracer at a first location in a reservoir, wherein the tracer mixes with subsurface fluid in the reservoir; collecting fluid samples at a second location in the reservoir; mixing a magnetic surface-enhanced Raman scattering (SERS) particle with the fluid samples; applying a magnetic field to the mixed fluid samples; and analyzing the fluid samples to detect a presence of the tracer in the fluid samples.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: December 18, 2018
    Inventors: Sehoon Chang, Wei Wang, Shannon L. Eichmann
  • Patent number: 10155973
    Abstract: The present disclosure provides systems for the rapid and sensitive detection of organisms and molecules in samples. Reactants that produce Raman-active products are used in combination with Raman light scattering. Such compounds may comprise phosphates permitting the detection of phosphatases. The present disclosure can also be used to measure enzyme-kinetics.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: December 18, 2018
    Assignee: SWORD DIAGNOSTICS, INC.
    Inventors: Neal Arthur Siegel, Samar Kumar Kundu, Charles Lester Ginsburgh
  • Patent number: 10150198
    Abstract: A method of inspecting a cutting blade having a cutting edge formed of abrasive grains of selected abrasive grain diameters which are bound by a bonding material, includes a cutting step of moving the chuck table and the cutting blade, which is being rotated at a high speed, relatively to each other along a direction perpendicular to an axis of rotation of a spindle, thereby forming a cut groove in the workpiece, and an inspecting step of capturing an image of the cut groove formed in the workpiece by image capturing means, and inspecting the state of the cut groove. The inspecting step examines whether or not the selected abrasive grain diameters are proper on the basis of any of the elements representing the size of an average chip, the number of chips, and the area of chips on both sides of the cut groove per unit length.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: December 11, 2018
    Assignee: DISCO CORPORATION
    Inventor: Kazuma Sekiya
  • Patent number: 10151629
    Abstract: Spectral imaging sensors and methods are disclosed. One spectral imaging sensor includes a light source, an array of coded apertures, one or more optical elements, and a photodetector. The light source is configured to emit a plurality of pulses of light toward an object to be imaged. The array of coded apertures is positioned to spatially modulate light received from the object to be imaged. The optical elements are configured to redirect light from the array of coded apertures. The photodetector is positioned to receive light from the one or more optical elements. The photodetector comprise a plurality of light sensing elements. The plurality of light sensing elements are operable to sense the light from the one or more optical elements in a plurality of time periods. The plurality of time periods have a same frequency as the plurality of pulses of light.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 11, 2018
    Assignee: University Of Delaware
    Inventors: Daniel L. Lau, Gonzalo R. Arce
  • Patent number: 10139329
    Abstract: The present disclosure is directed to a method of particle size determination for particles suspended within a light-transmissive medium. The method includes directing a monochromatic light source into the medium and collecting from the medium a Raman-scattered light spectrum. The method includes analyzing the Raman spectrum to determine an amount of Tyndall scattering of the Raman spectrum caused by particles within the medium, and thus determine the size and the number of particles mediating the Tyndall scattering.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: November 27, 2018
    Assignee: Kaiser Optical Systems Inc.
    Inventor: Harry Owen
  • Patent number: 10119917
    Abstract: This invention relates to an apparatus and method for performing bidirectional Raman spectroscopy of a sample, preferably a diffusely scattering sample, in which two excitation light sources are employed to illuminate the sample from two opposite directions to excite Raman scattering signal from the sample. The Raman scattering signal which transmits through the sample are collected by two optical devices each positioned on the opposite side of the sample to obtain two transmission Raman spectra of the sample, which enables the accurate determination of the composition of the whole sample.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: November 6, 2018
    Assignee: B & W Tek LLC
    Inventors: Jun Zhao, Xin Jack Zhou, Sean Xiaolu Wang
  • Patent number: 10119914
    Abstract: A fast, high-resolution localization microscopy method for a specimen containing fluorescence emitters. In a bright state, emitters emit fluorescent radiation upon excitation irradiation, and in a dark state, the fluorescence emitters do not emit fluorescent radiation upon excitation irradiation. The emitters can be brought from the bright state into the dark state by irradiation, and the dark state has a lifetime after which the emitters return to the bright state spontaneously, such that the emitters blink at a blinking frequency. The blinking specimen is imaged with a spatial resolution and detected with a camera, the intensity of the radiation is set such that emitters are isolated in the individual images in terms of the spatial resolution, and the refresh rate at which the images are produced is not lower than the blinking frequency. Locations are determined for isolated emitters in the images with an accuracy that exceeds the spatial resolution.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: November 6, 2018
    Assignee: CARL ZEISS MICROSCOPY GMBH
    Inventor: Thomas Kalkbrenner
  • Patent number: 10113948
    Abstract: A particle detection method in which particles in a sample are detected includes: a mounting step of mounting, on a stage portion, a fluid device including a channel through which the particles can move; an irradiation step of irradiating the channel with illumination light; and a detection step of detecting scattered light generated from the particles by irradiation with the illumination light. In the irradiation step, the illumination light is converged such as to enter the channel by passing through, among side surfaces of the channel, only the first side surface that faces an illumination light incident direction.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: October 30, 2018
    Assignees: The University of Tokyo, Nikon Corporation
    Inventors: Takanori Ichiki, Kuno Suzuki, Daishi Tanaka, Jiro Inoue, Kazuya Ota
  • Patent number: 10113952
    Abstract: A method for determining mineralogical or geochemistry of at least one geological sample with vibrational spectroscopy combined with laser-induced breakdown spectral measurements performed on the geological sample in a time variant manner with spectral acquisitions made after each of a plurality of measurement shots, spectral pre-processing performed as necessary, and subsequent analysis is applied to the collected data to determine at least one mineralogical or geochemistry parameter of the sample. The method can provide a rapid method to estimate mineralogy or geochemical parameters of a sample, which does not require sample preparation, and which can be non-destructive with respect to portions of the sample. A system for performing the method also is provided.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: October 30, 2018
    Assignee: Ingrain, Inc.
    Inventor: Kathryn Elizabeth Washburn
  • Patent number: 10107758
    Abstract: A scanning detection system is provided wherein emissions from locations in a flow cell are detected. In some embodiments, the system can comprise an excitation source, a photocleavage source, and modulating optics configured to cause an excitation beam generated by the excitation source to irradiate a first group of the fixed locations and to cause a photocleavage beam generated by the photocleavage source to irradiate a second group of the fixed locations, which is separate and apart from the first group of fixed locations. Methods of detecting sequencing reactions using such a system are also provided.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: October 23, 2018
    Assignee: Life Technologies Corporation
    Inventors: Mark F. Oldham, Eric S. Nordman, Hongye Sun, Steven J. Boege
  • Patent number: 10101209
    Abstract: A multi-analyte sensor system based on hollow core photonic bandgap fiber and Raman anti-Stokes spectroscopy. The system includes: i) an inlet to introduce an analyte sample into an analyzer chamber which analyzer includes; ii) a measurement system to derive the anti-Stokes spectral peaks and/or spectra of the sample; iii) a set of reference calibrants corresponding to the analytes of which the sample is primarily comprised; iv) a second inlet to introduce said calibrants into the analyzer chamber; v) a second measurement system to derive the anti-Stokes spectral peaks and/or spectra of the calibrants vi) an outlet through which the sample and calibrants are expelled from the analyzer chamber.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: October 16, 2018
    Assignee: Finesse Solutions, Inc.
    Inventors: Mark Selker, Barbara Paldus
  • Patent number: 10101271
    Abstract: A method for performing infrared analysis for measuring hydrocarbon contamination in water includes providing light from a light source; directing light from the light source through an experimental water sample; detecting the light transmitted from the experimental water sample; and determining a level of hydrocarbon contamination in the experimental water sample based on the light loss in the range between about 5700 cm?1 and 6300 cm?1. An apparatus for performing infrared analysis for measuring hydrocarbon contamination in water includes a controller operative to determine light loss through the sample cell and to determine a level of hydrocarbon contamination in the experimental water sample based on the light loss in the range between about 5700 cm?1 and 6300 cm?1.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: October 16, 2018
    Assignee: ABB Schweiz AG
    Inventor: Henry L. Buijs
  • Patent number: 10092222
    Abstract: A user authentication apparatus using a Raman spectrum is provided. The user authentication apparatus includes a Raman spectrum analyzer configured to analyze user characteristic information from a Raman spectrum of a user, and an authenticator configured to authenticate the user, based on the analysis.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: October 9, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: June Young Lee, Seong Ho Cho
  • Patent number: 10097264
    Abstract: A single photon avalanche diode based apparatus comprising: at least one array of single photon avalanche diodes configured to receive light generated externally to the apparatus, wherein the at least one array is configurable to be sub-divided into a plurality of sub-arrays, each sub-array able to receive a separate free space light communication channel; and a receiver configured to receive the output from each sub-array and output data based on the received plurality of sub-array separate free space light communication channel.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: October 9, 2018
    Assignee: STMICROELECTRONICS (RESEARCH & DEVELOPMENT) LIMITED
    Inventors: Aravind Venugopalan Nair Jalakumari, Neale Dutton
  • Patent number: 10094781
    Abstract: A system is presented. The system includes an electromagnetic radiation source configured to generate a mode-matched electromagnetic radiation that irradiates a gas-mixture filled in a gas compartment at a determined pressure ‘P’ bars, an intensity enhancement mechanism that internally reflects the mode-matched electromagnetic radiation a plurality of times to achieve an effective intensity ‘E’, of reflected electromagnetic radiation in a region of interest, that is ‘N’ times an intensity of the mode-matched electromagnetic radiation, and a detection subsystem that analyzes the gas-mixture based upon Raman scattered photons emitted from the region of interest, wherein a product of the ‘P’ and the ‘N’ is at least 30.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: October 9, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Rachit Sharma, Chayan Mitra, Vinayak Tilak
  • Patent number: 10088422
    Abstract: Apparatus and method for Raman-spectrography-based measurement of the composition of gas mixture in a high-temperature borehole. The method includes any of determining molar densities of individual alkanes of the mixture, introducing refractive index corrections, utilization of reference species internally to the measurement apparatus, correction for the effect of self-absorption and cross-absorption, as well as minimizing fluorescence when a liquid fraction is present in the borehole. The apparatus is configured to detect vibrational bands of CH, OH, CC, HS, NN and CO functional groups as well as collective modes in the fingerprint spectral region.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: October 2, 2018
    Assignee: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventors: Albert Ballard Andrews, Andrew Speck
  • Patent number: 10089734
    Abstract: A system for thermal transient imaging of an object includes a radiation source configured to irradiate the object with radiation in accordance with an excitation profile. An imaging device includes an array of detector pixels and is configured to detect thermal radiation from a surface of the object. A processor is configured to obtain a series of frames of thermal image data of the surface acquired by the imaging device over time when the object is irradiated by the radiation source. The processor is further configured to process, using the excitation profile, the series of frames of thermal image data to transform the thermal image data to an equivalent wave field representation that represents a series of depth-resolved virtual images of the object.
    Type: Grant
    Filed: January 21, 2018
    Date of Patent: October 2, 2018
    Inventor: Meir Gershenson
  • Patent number: 10088423
    Abstract: A disposable set (100) includes a tube; and a sensing member (104) press-fittingly insertable into the tube, the sensing member including: a first end (106) having a first diameter and including at least one through hole (112) positioned along a perimeter of the first end; a second end (108) having a second diameter and including at least one through hole positioned along a perimeter of the second end, the first diameter and the second diameter being substantially equal to an interior diameter of the tube; and a middle portion (110) located between the first end and the second end having a diameter that is less than the first diameter, the middle portion including at least one SERS sensing element (114), wherein the through holes in the first and second ends enable fluid to pass through the sensing member.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: October 2, 2018
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Rongsheng Lin, James Slepicka
  • Patent number: 10088370
    Abstract: A system and method for rapid thermometry using intrapulse spectroscopy can include a laser for propagating pulses of electromagnetic radiation to a region. Each of the pulses can be chirped. The pulses from the region can be detected. An intrapulse absorbance spectrum can be determined from the pulses. An instantaneous temperature of the region based on the intrapulse absorbance spectrum can be determined.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: October 2, 2018
    Assignee: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Robin Chrystie, Aamir Farooq
  • Patent number: 10085646
    Abstract: A contact-type endoscope surface enhanced Raman scattering (SERS) probe includes a gradient-index (GRIN) lens, a transparent substrate adhered to the GRIN lens, and a rough metallic layer adhered to an opposite side of the transparent substrate from the GRIN lens. The GRIN lens focuses light from a Raman spectrometer onto the rough metallic layer, and the rough metallic layer is positioned at the distal end of the contact-type endoscope SERS probe.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: October 2, 2018
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventors: Martin Feldman, Dooyoung Hah