With Raman Type Light Scattering Patents (Class 356/301)
  • Patent number: 10780654
    Abstract: The invention provides a method for 3D printing a 3D item (1), the method comprising depositing during a printing stage 3D printable material (201), to provide the 3D item (1) comprising 3D printed material (202), wherein the printing stage comprises: —3D printing a first 3D printable material (201a) to provide a first 3D printed material (202a), the first 3D printable material (201a) comprising a cross-linkable material; —creating a relief structure (610) in the first 3D printed material (202a) with a tool (630); and —3D printing a second 3D printable material (201b) to provide a second 3D printed material (202b), to provide a stack (620) of (i) 3D printed material (202) comprising the first 3D printed material comprising the relief structure (610), and (ii) the second 3D printed material (202b), wherein the method further comprises: —cross-linking at least part of the first 3D printed material (202a) comprising the relief structure (610) before depositing the second 3D printable material (202b).
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: September 22, 2020
    Assignee: SIGNIFY HOLDING B.V.
    Inventors: Ties Van Bommel, Rifat Ata Mustafa Hikmet
  • Patent number: 10775310
    Abstract: A detection apparatus, including: a laser configured to emit laser light towards an object to be detected; a Raman spectrometer configured to receive Raman light from the object; an imaging device configured to obtain an image of the object; a light sensor configured to receive light reflected and scattered by the object under irradiation of the laser light, and to determine the power of the received light; and a controller configured to control an operation of the detection apparatus based on the image obtained by the imaging device and the power determined by the light sensor. A detection method using the detection apparatus.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: September 15, 2020
    Assignee: NUTECH COMPANY LIMITED
    Inventors: Haihui Liu, Hongqiu Wang, Jianhong Zhang
  • Patent number: 10775246
    Abstract: In some examples, a temperature distribution sensor may include a laser source to emit a laser beam that is tunable over a wavelength range. The wavelength range may be less than a Raman bandwidth in a device under test (DUT), or of-the-order-of the Raman bandwidth in the DUT. A pulsed source may apply a pulse drive signal to the laser beam or to a modulator to modulate the laser beam that is to be injected into the DUT. A bandpass filter may be operatively disposed between the laser source and the DUT, and may be configured to an anti-Stokes wavelength that is narrower than the Raman bandwidth. A photodiode may be operatively disposed between the bandpass filter and the DUT to acquire, from the DUT, anti-Stokes optical time-domain reflectometer traces for two preset wavelengths of the laser beam to determine a temperature distribution for the DUT.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: September 15, 2020
    Assignee: VIAVI SOLUTIONS INC.
    Inventor: Vincent Lecoeuche
  • Patent number: 10772838
    Abstract: A powdery material mixing degree measurement device includes a discharger configured to discharge mixed powdery materials to a filler configured to fill, with the powdery materials, a vertically penetrating die bore of a compression-molding machine including a table including the die bore, a slidable lower punch including an upper end inserted to the die bore, and a slidable upper punch including a lower end inserted to the die bore, a plurality of movable portions configured to move the mixed powdery materials to the discharger, and a sensor configured to measure a mixing degree of the mixed powdery materials in the movable portions.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: September 15, 2020
    Assignee: KIKUSUI SEISAKUSHO LTD.
    Inventors: Jun Oyama, Naoshige Kitamura, Masaoki Murakoshi
  • Patent number: 10768050
    Abstract: A multi-analyte sensor system based on hollow core photonic bandgap fiber and Raman anti-Stokes spectroscopy. The system includes: i) an inlet to introduce an analyte sample into an analyzer chamber which analyzer includes; ii) a measurement system to derive the anti-Stokes spectral peaks and/or spectra of the sample; iii) a set of reference calibrants corresponding to the analytes of which the sample is primarily comprised; iv) a second inlet to introduce said calibrants into the analyzer chamber; v) a second measurement system to derive the anti-Stokes spectral peaks and/or spectra of the calibrants vi) an outlet through which the sample and calibrants are expelled from the analyzer chamber.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: September 8, 2020
    Assignee: Finesse Solutions, Inc.
    Inventors: Mark Selker, Barbara Paldus
  • Patent number: 10768115
    Abstract: The present disclosure includes discloses a method for analyzing a multi-component gas sample using spectroscopy in combination with the measurement of extrinsic or intrinsic properties of the gas sample. The results of the spectroscopic analysis and the measurement are combined to quantify a gas component unseen by the spectroscopic analysis.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: September 8, 2020
    Assignee: Kaiser Optical Systems Inc.
    Inventors: Joseph B. Slater, James M. Tedesco, Francis Esmonde-White
  • Patent number: 10760969
    Abstract: Systems and methods for reducing fluorescence and systematic noise in time-gated spectroscopy are disclosed. Exemplary methods include: a method for reducing fluorescence and systematic noise in time-gated spectroscopy may comprise: providing first light using an excitation light source; receiving, by a detector, first scattered light from a material responsive to the first light during a first time window; detecting a peak intensity of the first scattered light; receiving, by the detector, second scattered light from the material responsive to the first light during a second time window; detecting a peak intensity of the second scattered light; recovering a spectrum of the material by taking a ratio of the peak intensity of the first scattered light and the peak intensity of the second scattered light; and identifying at least one molecule of the material using the recovered spectrum and a database of identified spectra.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: September 1, 2020
    Assignee: BioSpex, Inc.
    Inventors: Zhenyou Wang, Wei Yang
  • Patent number: 10750947
    Abstract: A system and method for intraoperative fluorescence imaging. A system for intraoperative fluorescence imaging includes a visible light source, a laser light source, a visible light image detector, a fluorescence image detector, radio frequency (RF) circuitry, and an image processing system. The RF circuitry is coupled to the laser light source and the fluorescence image detector. The RF circuitry is configured to modulate laser light generated by the laser source, and modulate an intensifier of the fluorescence image detector. The image processing system is coupled to the visible light image detector and the fluorescence image detector. The image processing system is configured to merge a fluorescence image produced by the fluorescence image detector and a visible light image produced by the visible light image detector to generate an intraoperative image showing an outline of a region of interest identified in the fluorescence image overlaid on the visible light image.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: August 25, 2020
    Assignee: Board of Regents of the University of Texas System
    Inventors: Banghe Zhu, Eva M. Sevick-Muraca, John C. Rasmussen
  • Patent number: 10753849
    Abstract: An apparatus (10) for characterizing particles, comprising: a microscope objective with an optical axis and a depth of field; a holder cell (22) configured to position the particles in a generally planar volume below the microscope objective, the planar volume being substantially normal to the optical axis and having a depth that is less than or equal to the depth of field, wherein a portion of the cell holder (22) for positioning in the optical axis of the microscope objective is substantially free of significant spectral features in a Raman spectral range; an x-y stage (20) to move the microscope objective relative to the holder cell (22) in x and y directions to align particles with the optical axis of the microscope objective while the particles are held by the holder cell (22), a detector (18) for acquiring an image of a particle through the microscope objective, a laser operable to illuminate a particle held by the holder cell (22), a Raman spectrometer (16) arranged to obtain a spectrum including the R
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: August 25, 2020
    Assignee: Malvern Panalytical Limited
    Inventors: John McCaffrey, Kevin Dahl, Peter Bennett, Vishal Patil, E. Neil Lewis
  • Patent number: 10743848
    Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: August 18, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, INVENIO IMAGING, INC.
    Inventors: Daniel Orringer, Christian Freudiger, Jay Trautman, Andrew Kelly
  • Patent number: 10746730
    Abstract: A method for characterizing extracellular vesicles at an individual level is described. It comprises obtaining a sample comprising extracellular vesicles to be characterized and functionalizing the extracellular vesicles with plasmonic nanoparticles or a plasmonic coating. The method further comprises irradiating the individual extracellular vesicles with a laser beam and detecting a surface enhanced Raman spectroscopy signal from said individual extracellular vesicle.
    Type: Grant
    Filed: December 18, 2016
    Date of Patent: August 18, 2020
    Assignee: UNIVERSITEIT GENT
    Inventors: Kevin Braeckmans, Stephan Stremersch, Andre Skirtach, Stefaan De Smedt, Koen Raemdonck, Joseph Demeester, Juan Fraire
  • Patent number: 10746438
    Abstract: Disclosed is a nanowire bundle array. Particularly, the nanowire bundle array according to an embodiment of the present disclosure includes a plurality of nanowire assemblies arranged therein. Each of the nanowire assemblies includes nanowires, a surface of at least a portion of which is coated with a thin metal film and the widths between the nanowires gradually decrease from one end to another end.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: August 18, 2020
    Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
    Inventors: Kyoung Sik Kim, Kyu Young Bae, Gu Min Kang
  • Patent number: 10741991
    Abstract: A narrowband laser apparatus may be provided with a laser resonator including optical elements for narrowing a spectral linewidth, a spectrometer configured to detect spectral intensity distributions of multiple pulses included in a pulsed laser beam output from the laser resonator, a spectral waveform producer configured to produce a spectral waveform by adding up the spectral intensity distributions of the multiple pulses, a device function storage configured to store a device function of the spectrometer, a wavelength frequency function generator configured to generate a wavelength frequency function which represents a frequency distribution of center wavelengths of the multiple pulses, and a deconvolution processor configured to perform deconvolution processing on the spectral waveform with the device function and the wavelength frequency function.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: August 11, 2020
    Assignee: Gigaphoton Inc.
    Inventors: Takahito Kumazaki, Keisuke Ishida, Hiroshi Furusato
  • Patent number: 10718708
    Abstract: An object is to provide a technique that can evaluate biological tissues such as cartilage tissue and regenerated tissues such as regenerated cartilage. A method for observing a dynamic physical property of a biological tissue according to the present invention is that a biological tissue is irradiated with a pulsed light having a wavelength of a far-infrared wavelength region modulated into circular polarized lights by applying bias voltages to a radiation means (3) having an antenna electrode films of orthogonal (2)-axis structure with phases shifted using high-voltage high-speed modulation means (13), and dynamic physical property of the biological tissue is observed on the basis of a spectrum obtained by vibration optical activity spectroscopy.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: July 21, 2020
    Assignees: ADVANCED BIO-SPECTROSCOPY CO., LTD, THE UNIVERSITY OF TOKYO
    Inventors: Takashi Ushida, Katsuko Furukawa, Seizi Nishizawa
  • Patent number: 10718664
    Abstract: A micro-fluidic system comprising means for optically trapping a particle and a Raman excitation source for causing Raman scatter from the particle whilst it is in the optical trap.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: July 21, 2020
    Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
    Inventors: Kishan Dholakia, Phillip Ronald Thomas Jess, Michael Mazilu
  • Patent number: 10718668
    Abstract: State-of-the-art portable Raman spectrometers use discrete free-space optical components that must be aligned well and that don't tolerate vibrations well. Conversely, the inventive spectrometers are made with monolithic photonic integration to fabricate some or all optical components on one or more planar substrates. Photonic integration enables dense integration of components, eliminates manual alignment and individual component assembly, and yields superior mechanical stability and resistance to shock or vibration. These features make inventive spectrometers especially suitable for use in high-performance portable or wearable sensors. They also yield significant performance advantages, including a large (e.g., 10,000-fold) increase in Raman scattering efficiency resulting from on-chip interaction of the tightly localized optical mode and the analyte and a large enhancement in spectral resolution and sensitivity resulting from the integration of an on-chip Fourier-transform spectrometer.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: July 21, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Tian Gu, Derek Matthew Kita, Juejun Hu
  • Patent number: 10712280
    Abstract: A gas conduit directs a flow of gas from a gas flow source. A surface enhanced luminescence (SEL) stage is within the conduit and includes a substrate and nano fingers projecting from the substrate. A heater heats the nano fingers to a temperature so as to soften the nano fingers such that the nano fingers collapse towards each other to capture molecules entrained in the gas therebetween.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: July 14, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Ning Ge, Robert G. Walmsley, Helen A. Holder, Steven J. Simske, Anita Rogacs, Viktor Shkolnikov
  • Patent number: 10712279
    Abstract: An activatable SEL sensor stage may include a substrate, cation metal-based material masses supported by the substrate and isolated from one another and dielectric capping layer over the cation metal-based material masses to inhibit oxidation of the cation metal-based material masses.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: July 14, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Ning Ge, Helen A. Holder, Steven J. Simske, Anita Rogacs, Viktor Shkolnikov
  • Patent number: 10712278
    Abstract: Provided in one example is an analyte detection package that includes a chamber, a surface-enhanced luminescence analyte stage within the chamber, and a lens integrated as part of the package to focus radiation onto the analyte stage.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: July 14, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Charles M. Santori, Ning Ge, Zhiyong Li, Steven Barcelo
  • Patent number: 10707051
    Abstract: An apparatus for collection, distribution, and analysis of cathodoluminescence (CL) and other light signals in an electron microscope is provided. The optical hub, utilizing a linear-translating fold-mirror and mounted to the electron microscope, is used to receive essentially collimated light collected from a collection-mirror and efficiently route the collected light to a plurality of light-analysis instruments. The linear-translating fold-mirror can provide fine positional alignment of the light signal, and in an aspect of the invention can be used to select or scan a portion of the collected light-pattern into an optical slit or aperture. In one aspect, the optical hub includes a light filter mechanism that can track the movement of the fold-mirror. In an aspect, the optical hub also controls the positioning of the collection-mirror in proximity to the specimen being analyzed.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: July 7, 2020
    Assignee: Gatan, Inc.
    Inventors: John Andrew Hunt, Michael Bertilson, Tom Worsley
  • Patent number: 10700665
    Abstract: Techniques are disclosed for forming high frequency film bulk acoustic resonator (FBAR) devices using epitaxially grown piezoelectric films. In some cases, the piezoelectric layer of the FBAR may be an epitaxial III-V layer such as an aluminum nitride (AlN) or other group III material-nitride (III-N) compound film grown as a part of a III-V material stack, although any other suitable piezoelectric materials can be used. Use of an epitaxial piezoelectric layer in an FBAR device provides numerous benefits, such as being able to achieve films that are thinner and higher quality compared to sputtered films, for example. The higher quality piezoelectric film results in higher piezoelectric coupling coefficients, which leads to higher Q-factor of RF filters including such FBAR devices. Therefore, the FBAR devices can be included in RF filters to enable filtering high frequencies of greater than 3 GHz, which can be used for 5G wireless standards, for example.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: June 30, 2020
    Assignee: Intel Corporation
    Inventors: Han Wui Then, Sansaptak Dasgupta, Marko Radosavljevic
  • Patent number: 10697894
    Abstract: In order to check a material for transplantation, at least one Raman spectrum (41, 42) of the material is detected. An electronic evaluation device determines an information, from which depends a suitability of the material for use during the transplantation, by evaluating the at least one Raman spectrum (41, 42).
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: June 30, 2020
    Assignee: CellTool GmbH
    Inventors: Karin Schütze, Raimund Schütze
  • Patent number: 10677752
    Abstract: Aspects of the subject disclosure may include, for example, an apparatus including a material having one or more atomic layers with two or less degrees of freedom for motion of charges in the material, and a gate coupled to the material for controlling charge concentration of the material. The material can have constricted sides, a first through-hole, and a first port and a second port for conduction of charges in the material. The gate can have a second through-hole that is at least partially aligned with the first through-hole. A first voltage potential can be applied to the first port and the second port, along with a second voltage potential applied to the gate which adjusts the charge concentration of the material. A sensor can be used to measure a change in electrical properties of the material caused by a target material traversing the first through-hole of the material. Additional embodiments are disclosed.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: June 9, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Jean-Pierre Leburton
  • Patent number: 10670460
    Abstract: The present invention relates to a highly flexible stand-off distance chemical detector system such as can be used, for example, for standoff detection of explosives. Instead of a combined laser interrogation source and optical content detector on the same platform, those features are carried on separate platforms, including having plural optical content detectors on individual platforms. In one embodiment, the detector platforms are mobile remote-control apparatus. This allows collection and evaluation of optical content/information from multiple collection positions/directions and high flexibility in maneuverability of the collection function relative the target.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: June 2, 2020
    Assignee: Alakai Defense Systems, Inc.
    Inventor: Robert Douglas Waterbury
  • Patent number: 10670528
    Abstract: A Raman spectroscopic measurement system for measuring the material composition of a mixed phase fluid having a gas phase dispersed in a liquid phase or vice versa is disclosed, which includes an insert to be inserted into a process. The insert includes a measurement chamber partially defined by a phase separating membrane that enables the gas phase to diffuse into and out of the measurement chamber and facilitates coalescing of the liquid phase which into a collector. A first probe of the measurement system is configured to transmit excitation light into the measurement chamber and to receive a Raman signal emanating from the gas phase therein, and a second probe is configured to transmit excitation light into the drain and to receive a Raman signal emanating from the liquid phase therein. The measurement system further includes a spectrometer to determine the material composition of the fluid from the Raman signals.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: June 2, 2020
    Assignee: Kaiser Optical Systems Inc.
    Inventor: Joseph B. Slater
  • Patent number: 10663401
    Abstract: A method may include scanning a surface of a composite workpiece with multiple electromagnetic pulses, each of the multiple electromagnetic pulses being associated with a respective location on the surface of the composite workpiece.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: May 26, 2020
    Assignee: THE BOEING COMPANY
    Inventors: Morteza Safai, Gary E. Georgeson
  • Patent number: 10661347
    Abstract: A nanoporous gold disk (NPGD) as a novel surface-enhanced Raman spectroscopy (SERS) substrate. NPGD has SERS enhancement factor similar to that of gold nanoshells, but allows, for example, at least three times more benzenethiol molecules to be attached to its surface due to large surface-to-volume ratio. The high capacity enables the rapid detection of attomole-level benzenethiol molecules with relatively high detector temperatures. Additionally, a fabrication process to make NPGD with controlled size and highly reproducible SERS activities.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: May 26, 2020
    Assignee: UNIVERSITY OF HOUSTON SYSTEM
    Inventor: Wei-Chuan Shih
  • Patent number: 10656093
    Abstract: In one example, a structure for surface enhanced Raman spectroscopy includes a cluster of metal nanoparticles in a hole.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 19, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Steven Barcelo, Ning Ge, Zhiyong Li
  • Patent number: 10648916
    Abstract: A surface enhanced luminescence (SEL) sensor may include a substrate and nano fingers projecting from the substrate. The nano fingers may include a nano finger extending along an axis. The nano finger may include a plasmonically active cap and a pillar supporting the plasmonically active cap. The pillar may have an asymmetric material composition with respect to the axis.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: May 12, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Ning Ge, Viktor Shkolnikov, Anita Rogacs, Steven J. Simske
  • Patent number: 10633695
    Abstract: Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA, mRNA, microRNA, and small nucleotide polymorphisms (SNPs). The nanoproprobes can be used in vito in sensitive detection methods for diagnosis of diseases and disorders including cancer. Multiplexing can be performed using the nanoprobes such that multiple targets can be detected simultaneously in a single sample. The methods of use of the nanoprobes include detection by a visible color change. The nanoprobes can be used in vivo for treatment of undesirable cells in a subject.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: April 28, 2020
    Assignee: DUKE UNIVERSITY
    Inventors: Tuan Vo-Dinh, Hsin-Neng Wang, Andrew Fales
  • Patent number: 10620050
    Abstract: A vibrational sum frequency generation spectroscopy system with pulse shaping is provided. The pulse shaping provides tunable NIR-Shaped light pulses based on user input parameters which may be specified to customize the system for different experimental and testing conditions or needs.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: April 14, 2020
    Assignee: UT-BATTELLE, LLC
    Inventors: Azhad U. Chowdhury, Benjamin L. Doughty, Daniel A. Lutterman, Yingzhong Ma, Tessa R. Calhoun, Brianna R. Watson
  • Patent number: 10620125
    Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: April 14, 2020
    Assignee: ONDAVIA, INC.
    Inventors: Mark C. Peterman, Merwan Benhabib, Samuel Kleinman
  • Patent number: 10613032
    Abstract: A spectroscopy apparatus, a spectroscopy method, and a bio-signal measuring apparatus are provided. The spectroscopy apparatus may include: a dispersive element configured to divide an incident light into a plurality of lights having different output angles; and a filter array configured to divide the plurality of lights, with a higher spectral resolution than a spectral resolution of the dispersive element, and provide the divided plurality of lights to a detector.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: April 7, 2020
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sung Mo Ahn, Seok Ho Yun
  • Patent number: 10613025
    Abstract: An infrared (IR) sensor and a method of detecting molecular species in a liquid. In one embodiment, the method comprises i) generating IR light from an IR light source; ii) receiving in an optical fiber the IR light from the IR light source, wherein a selective ion-exchange (IX) medium is associated with the optical fiber and the IR light generates an evanescent field about the optical fiber as the IR light propagates therethrough, the selective IX medium configured to transport an ion species in a subject liquid about the optical fiber; and iii) receiving in an IR light detector the IR light from the optical fiber, wherein the ion species affects the evanescent field and thereby a characteristic of the IR light.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: April 7, 2020
    Assignee: Max-IR Labs, LLC
    Inventor: Ecatherina Roodenko
  • Patent number: 10598599
    Abstract: Methods and materials for determining the affinity of separation materials for targeted species are described. A composite separation medium is described that combines a separation material such as an ion exchange material or a sorbent with an SERS substrate. Methods and materials can be utilized to determine the distribution coefficient of a species for a separation material after running a single separation protocol followed by examination of the separation material of the protocol according to SERS. Disclosed methods can be utilized to determine the affinity of existing separation materials for targeted species as well as to determine the affinity of newly engineered separation materials to characterize species.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: March 24, 2020
    Assignee: Savannah River Nuclear Solutions, LLC
    Inventors: Fernando F. Fondeur, Simona H. Murph, Kathryn L. Taylor-Pashow, David T. Hobbs
  • Patent number: 10588513
    Abstract: An optical apparatus comprising a disposable non-magnetic optical fibre probe for coupling light into a sample and receiving light from the sample for performing Raman spectroscopy, and a non-magnetic optical extension releasably connected to the disposable non-magnetic optical probe for transmitting light into the disposable non-magnetic optical probe and receiving light from the disposable non-magnetic optical probe.
    Type: Grant
    Filed: January 20, 2014
    Date of Patent: March 17, 2020
    Assignee: UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
    Inventors: Kishan Dholakia, Praveen Cheriyan Ashok
  • Patent number: 10557798
    Abstract: A housing may include sidewalls and a base extending between and supported by the sidewalls. The base and the sidewalls form a cavity. The housing support they substrate. The substrate supports a surface enhanced luminescence stage between the substrate and the base.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: February 11, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Chien-Hua Chen, Michael W. Cumbie, Devin A. Mourey
  • Patent number: 10556557
    Abstract: A moving object includes a box-shaped accommodation unit provided on an outer surface of an automobile body, and moves on a road surface. The accommodation unit detachably accommodates a detection device that detects suspended matters or radiation in the air nearby the automobile body.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: February 11, 2020
    Assignee: SHARP KABUSHIKI KAISHA
    Inventor: Yoshiteru Kikuchi
  • Patent number: 10548481
    Abstract: Systems and methods for adjusting for non-invasive measurement of biological analytes. Exemplary methods include: illuminating an analyte using first light, the first light having a first excitation wavelength; detecting a first spectrum from the analyte illuminated by the first light, the first spectrum including a first Raman signal and fluorescence; illuminating the analyte using second light, the second light having a second excitation wavelength; detecting a second spectrum; illuminating the analyte using third light, the third light having a third excitation wavelength; detecting a third spectrum; recovering the first Raman signal using the first spectrum, the second spectrum, and the third spectrum using an inverse transform; and using the first Raman signal to identify and measure at least one molecule of the analyte using a database of identified Raman signals.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: February 4, 2020
    Assignee: BioSpex, Inc.
    Inventors: Wei Yang, Leyun Zhu
  • Patent number: 10539507
    Abstract: An analyte detection package includes a chamber, a surface-enhanced luminescence analyte stage within the chamber, and a tunable lens integrated with the package to focus radiation onto the analyte stage.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: January 21, 2020
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Ning Ge, Helen A Holder, Anita Rogacs, Viktor Shkolnikov
  • Patent number: 10533948
    Abstract: A carrier for use in single molecule detection is related. The carrier includes a substrate; a middle layer, on the substrate; and a metal layer, on the middle layer; wherein the substrate is a flexible substrate, the middle layer includes a base and a patterned bulge on the base, the patterned bulge includes a plurality of strip-shaped bulges, the metal layer is on the patterned bulge, the carrier further includes a carbon nanotube composite structure between the metal layer and the patterned bulge.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: January 14, 2020
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Ying-Cheng Wang, Yuan-Hao Jin, Qun-Qing Li, Shou-Shan Fan
  • Patent number: 10535495
    Abstract: A system and method for imaging a sample having a complex structure (such as an integrated circuit). The sample is placed on a motion system that moves the sample with respect to an electron beam generator that is used in imaging the sample. The motion system affords thirteen degrees-of-freedom for movement of the sample, by providing a rotation stage, a fine 6-axis piezoelectric-driven stage, and a coarse 6-axis hexapod stage. Various detectors gather information to image the sample. Interferometric and/or capacitive sensors are used to measure the position of the sample and motion system.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: January 14, 2020
    Assignee: BAE Systems Information and Electronic Systems Integration Inc.
    Inventors: Chris L. Willis, Eugene M. Lavely, Adam J. Marcinuk, Paul R. Moffitt, Jonathan R. Takahashi
  • Patent number: 10527494
    Abstract: The present disclosure relates to a substrate with multiple nano-gaps and a manufacturing method therefor, and more particularly to a multiple nano-gaps substrate with high absorption and capable of using light sources in a wide range, and a manufacturing method therefor.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: January 7, 2020
    Assignee: Korea Intitute of Machinery & Materials
    Inventors: Sung Gyu Park, Jung Heum Yun, Dong Ho Kim, Byung Jin Cho, Jung Dae Kwon, Chae Won Mun
  • Patent number: 10530118
    Abstract: Reflection resistances of respective fiber lasers in a state where an entire fiber laser system is in operation are evaluated. Each of fiber lasers (2 through 4) includes (i) a laser beam measuring section (28) configured to measure a power of a laser beam which a low reflection FBG (26) has transmitted therethrough and (ii) a Stokes beam measuring section (29) configured to measure a power of a Stokes beam which a high reflection FBG (24) has transmitted therethrough.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: January 7, 2020
    Assignee: FUJIKURA LTD.
    Inventor: Masahiro Kashiwagi
  • Patent number: 10527837
    Abstract: Method for obtaining an super-resolution image (22) of an object (5), based upon an optical microscope (21) including a support plate (6) for bearing the object, an illumination source (1) for focusing an illumination beam (14) onto a target region of the support plate, a digital camera (9) including a matrix of sensors, comprising: capturing, by the digital camera, a first image of the target region; extracting, from the first image, a first block of pixel values provided by a sub-matrix (B0) of the matrix of sensors; displacing, by a sub-diffraction limited distance, the support plate by the displacement block along a displacement axis; capturing, by the digital camera, a second image of the target region; extracting, from the second image, a second block of pixel values provided by the sub-matrix (B0) of the matrix of sensors; storing said first and second blocks of pixel values as a first and second blocks of pixel values to be placed right next each other in the super-resolution image along the image axi
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: January 7, 2020
    Assignees: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Bruno Robert, Andrew Gall, Dmitrij Frolov, Rienk Van Grondelle
  • Patent number: 10527907
    Abstract: A coherent anti-stokes Raman scattering apparatus for imaging a sample comprises an optical output; an optical source arranged to generate a first optical signal at a first wavelength; and a nonlinear element arranged to receive the first optical signal, where the nonlinear element is arranged to cause the first optical signal to undergo four-wave mixing on transmission through the nonlinear element such that a second optical signal at a second wavelength and a third optical signal at a third wavelength are generated, wherein an optical signal pair comprising two of the first, second and third optical signals is provided to the optical output for imaging the sample.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: January 7, 2020
    Assignee: NKT PHOTONICS A/S
    Inventors: Anatoly Grudinin, John Clowes, Pascal Dupriez, Michael Yarrow
  • Patent number: 10520443
    Abstract: An analyte detection system includes an analyte detection package to be presented to a reading device, and a focus mechanism to adjust a focal point of the analyte detection package relative to the reading device, with the analyte detection package including a surface-enhanced luminescence analyte stage, the reading device including optics to receive scattered radiation emitted luminescence from the analyte stage, and the focus mechanism to adjust the focal point relative to the optics.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: December 31, 2019
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Anita Rogacs, Viktor Shkolnikov, Ning Ge
  • Patent number: 10520440
    Abstract: Molecule sensing apparatus. The apparatus has first and second chambers, an input port extending into the first chamber, a fluid channel extending from the first chamber to the second chamber, and a surface-enhanced substrate in the second chamber.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: December 31, 2019
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Devin Alexander Mourey, James William Stasiak, James Elmer Abbott, Jr., Zhiyong Li
  • Patent number: 10517516
    Abstract: Provided is a monitor for monitoring the condition of the interior of a living organism from the surface of the living organism. The monitor is provided with: a probe which includes an observation window and is attached to the organism surface; a unit which irradiates, with a laser, at least a portion of an observation region; a unit which detects scattered light resulting from the laser irradiation; a Doppler analysis unit and a SORS analysis unit which narrow down the observation spots to a first observation spot; and a CARS analysis unit which obtains the optical spectrum for at least one component, and outputs first information indicating the condition of the organism interior on the basis of the intensity of the spectrum.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: December 31, 2019
    Assignee: ATONARP INC.
    Inventor: Prakash Sreedhar Murthy
  • Patent number: 10519365
    Abstract: A luminescent hybrid nanomaterial comprising: at least one inorganic nanomaterial comprising an inorganic first compound; and at least one second compound comprising a first aggregation-induced emission moiety, wherein the at least one second compound is grafted on at least part of a surface of the inorganic first compound.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: December 31, 2019
    Assignees: Centre National de la Recherche Scientifique, Université Aix-Marseille, Université de Rennes 1
    Inventors: Jörg Ackermann, Olivier Margeat, Muriel Hissler, Pierre Antoine Bouit