Abstract: Disclosed is a carboxylic acid-functionalized 3-dimensional SERS substrate. A carboxylic acid-functionalized 3-dimensional SERS substrate according to an embodiment of the present invention includes a substrate; a 3-dimensional nanostructure including a multistacked metal nanowire array formed by alternately and repeatedly transfer printing a single-layer metal nanowire array, laminated on a polymer mold on which a pattern of a master mold is duplicated, onto the substrate 110 to be perpendicular to each other; and a functionalized carboxylic acid into which a residue of the polymer mold present on the 3-dimensional nanostructure is functionalized and which enables a target analyte to immobilize.

Abstract: A handheld Surface-Enhanced Raman Spectroscopy (SERS) device for detecting a biomarker in a sample collected from a subject. The device comprises a laser generator configured to produce a laser beam; a nanoporous anodic aluminum oxide (NAAO) substrate configured to receive the sample collected from the subject; wherein the laser beam reaches the sample on the NAAO substrate and is reflected or deflected to produce a light signal; and a light sensor configured to receive the light signal reflected or deflected from the sample; wherein the device is handheld and detects the biomarker in the sample; wherein the NAAO substrate comprises a multilayered nanoporous aluminum layer; wherein the multilayered nanoporous aluminum layer comprises a base aluminum layer, and a nanoporous aluminum layer on top of the base aluminum layer; and wherein the nanoporous aluminum layer comprises a plurality of nanocavities.

Abstract: A computer-implemented method of transmitting through a disordered medium from a transmitter to a receiver an image represented as input coherent electromagnetic radiation, the disordered medium having a transmission matrix comprising a plurality of complex-valued transmission constants that relate said input coherent electromagnetic radiation to output electromagnetic radiation at said receiver, which method comprises the steps of: performing a characterising process on said disordered medium to determine said transmission matrix; using said transmitter to transmit said image through said disordered medium; performing a reconstruction process using said transmission matrix to generate a reconstructed image from the output electromagnetic radiation at said receiver; wherein in said characterisation process the step of determining said transmission matrix comprises: determining said complex-valued transmission constants as real-valued transmission constants by using an approximately linear relationship bet

Abstract: An adhesion interface observation method is adapted to observe a region in vicinity of an adhesion interface following adhesion and curing of an adhesive that is coated on adhered members and adheres the adhered members to each other. The adhesion interface observation method includes: exposing the cured adhesive by removing one of the adhered members; forming an observation region by cutting a predetermined part of the adhesive by a predetermined thickness; obliquely cutting the observation region in an oblique direction that is inclined with respect to a thickness direction of the observation region; and observing, by a surface-enhanced Raman scattering spectroscopy, Raman scattering light generated by applying excitation light to an observation possible region that is positioned on a side, of a part of the observation region having been subjected to the oblique cutting, on which a thickness of the part of the observation region is small.

Abstract: Configurable handheld biological analyzers and related biological analytics methods are described for identification of biological products based on Raman spectroscopy. A biological classification model configuration is loaded into a computer memory of a configurable handheld biological analyzer having a processor and a scanner. The biological classification model configuration includes a biological classification model configured to receive a Raman-based spectra dataset defining a biological product sample as scanned by the scanner. A spectral preprocessing algorithm is executed to reduce a spectral variance of the Raman-based spectra dataset. The biological classification model identifies a biological product type based on the Raman-based spectra dataset and further based on a classification component selected to reduce at least one of (1) a Q-residual error or (2) a summary-of-fit value of the biological classification model.

Abstract: A holographic imaging system comprises an imaging light source defining an imaging light path, an active light source defining an active light path directed at a target, and a polarizer configured to modify the polarization of the active light path. The system further comprises a polarization beam splitter positioned in the active light path and the imaging light path, configured to separate the active light path and the imaging light path, and a photodetector positioned at a terminus of the active light path. The photodetector is configured to measure a reflection of the active light source. A method of holographic imaging is also described.

Abstract: A method of increasing a surface-enhanced Raman scattering (SERS) signal of a compound is provided. The method includes dissolving the compound in water to form a solution, adding a substrate at least partially coated with gold nanoparticles to the solution to form a mixture, removing the substrate from the mixture and washing with water to form a SERS sample having at least a portion of molecules of the compound adsorbed to the gold nanoparticles on the substrate, and recording a SERS spectrum of the SERS sample. The gold nanoparticles are in a two-dimensional (2D) monolayer assembly on the substrate and are 10-250 nm in size. The SERS signal of the SERS spectrum is higher than a SERS signal of a SERS spectrum of the compound on the substrate without the gold nanoparticles.

Abstract: A server including a storage and a controller is communicably connected with a communication terminal. The storage is configured to store a processing data and an analysis data for each of a plurality of analysis targets. The processing data relates to a processing condition for forming a concavo-convex structure on a detection substrate to be used in performing a spectroscopic analysis. The analysis data is used to analyze the analysis target from a spectroscopic spectrum of the analysis target obtained by the spectroscopy analysis. Upon receiving a signal requesting the processing data, the controller is configured to select the processing data corresponding to the analysis target and transmit the selected processing data to the communication terminal. Upon receiving a spectroscopic spectrum, the controller is configured to use the analysis data to analyze the spectroscopic spectrum.

Abstract: A method of increasing a surface-enhanced Raman scattering (SERS) signal of a compound is provided. The method includes dissolving the compound in water to form a solution, adding a substrate at least partially coated with gold nanoparticles to the solution to form a mixture, removing the substrate from the mixture and washing with water to form a SERS sample having at least a portion of molecules of the compound adsorbed to the gold nanoparticles on the substrate, and recording a SERS spectrum of the SERS sample. The gold nanoparticles are in a two-dimensional (2D) monolayer assembly on the substrate and are 10-250 nm in size. The SERS signal of the SERS spectrum is higher than a SERS signal of a SERS spectrum of the compound on the substrate without the gold nanoparticles.

Abstract: A method of increasing a surface-enhanced Raman scattering (SERS) signal of a compound is provided. The method includes dissolving the compound in water to form a solution, adding a substrate at least partially coated with gold nanoparticles to the solution to form a mixture, removing the substrate from the mixture and washing with water to form a SERS sample having at least a portion of molecules of the compound adsorbed to the gold nanoparticles on the substrate, and recording a SERS spectrum of the SERS sample. The gold nanoparticles are in a two-dimensional (2D) monolayer assembly on the substrate and are 10-250 nm in size. The SERS signal of the SERS spectrum is higher than a SERS signal of a SERS spectrum of the compound on the substrate without the gold nanoparticles.

Abstract: A method and verification system for verifying pharmaceuticals packaged within a pouch using a pharmacy packaging system. The method includes activating a first light source to illuminate the pharmaceutical pouch, capturing a first image of the pharmaceutical pouch while illuminated by the first light source, activating a second light source to illuminate the pharmaceutical pouch, and capturing a second image of the pharmaceutical pouch while illuminated by the second light source. The method further includes generating a third image based on the first image and the second image, generating a dashboard to simultaneously display first images, second images, and third images from a plurality of pharmaceutical pouches, providing a number of pills indication of a number of pills detected in the pouch against a number of pills expected in the pouch, and displaying the dashboard.

Abstract: An optical assembly is disclosed including two laterally variable bandpass optical filters stacked at a fixed distance from each other, so that the upstream filter functions as a spatial filter for the downstream filter. The lateral displacement may cause a suppression of the Oblique beam when transmission passbands at impinging locations of the oblique beam onto the upstream and downstream filters do not overlap. A photodetector array may be disposed downstream of the downstream filter. The optical assembly may be coupled via a variety of optical conduits or optical fibers for spectroscopic measurements of a flowing sample.

Abstract: A measuring device able to be closely attached to an outer wall of a movable or fixed object located in an air flow. The measuring device comprises a flexible envelope having a cavity provided with an opening orifice. At least one optical fiber is provided in the cavity, the opening orifice of which is closed by the wall on which the envelope is applied. In this way, the fiber is positioned as closely as possible to the wall for which measurements are desired.

Abstract: A surface-enhanced Raman scattering (SERS)-active electrode include a solid support; a porous oxide layer containing transition metal oxide nanoparticles present on a surface of the solid support and has a mean pore size of 2 to 30 nm; and at least one of noble metal nanoneedles and noble metal nanorings present on the porous oxide layer. The noble metal nanoneedles have an average length of 350-800 nm, a flat end with an average width in a range of 100-150 nm, and a pointed end. The noble metal nanorings have a thickness of 50-300 nm and are present in the form of annular clusters having various elliptical shapes with an average diameter in a range of 35-60 nm.

Abstract: A method of increasing a surface-enhanced Raman scattering (SERS) signal of a compound is provided. The method includes dissolving the compound in water to form a solution, adding a substrate at least partially coated with gold nanoparticles to the solution to form a mixture, removing the substrate from the mixture and washing with water to form a SERS sample having at least a portion of molecules of the compound adsorbed to the gold nanoparticles on the substrate, and recording a SERS spectrum of the SERS sample. The gold nanoparticles are in a two-dimensional (2D) monolayer assembly on the substrate and are 10-250 nm in size. The SERS signal of the SERS spectrum is higher than a SERS signal of a SERS spectrum of the compound on the substrate without the gold nanoparticles.

Abstract: Systems and method for the delivery of a pump laser using optical diffraction are described herein. In certain embodiments, a system includes a substrate and a waveguide layer formed on the substrate. The waveguide layer includes a first waveguide of a first material configured to receive a probe laser for propagating within the first waveguide. The waveguide layer additionally includes a second waveguide configured to receive a pump laser for propagating within the second waveguide. Further, the waveguide layer includes one or more diffractors configured to direct a portion of the pump laser out of the second waveguide and through the first waveguide.

Abstract: A method of determining the identity and concentration of a target analyte present in a biological sample includes: introducing a first target analyte into a hollow core of an optical fiber; introducing a first reference calibrant into the hollow core of the optical fiber; transmitting light from a laser light source through the hollow core of the optical fiber and the first target analyte to generate a first Raman anti-Stokes analyte emission corresponding to the first target analyte; receiving the first Raman anti-Stokes analyte emission at a spectral analysis system optically coupled to the optical fiber; and deriving Raman anti-Stokes spectral peaks or spectra of the first target analyte at the spectral analysis system based on the first Raman anti-Stokes analyte emission.

Abstract: An integrated device for the detection of cancerous tissue including an optical fiber configured to receive at a first end modulated infrared light and to conduct the modulated infrared light from the first end to a second end; and a plasmonic metasurface, disposed on the second end of the optical fiber, configured to localize evanescent infrared light to sub-I 00 nanometer distances from the plasmonic metasurface of the optical fiber such that the localized evanescent infrared light penetrates only the membrane portion of a cell held against the second end, wherein the second end is configured to receive reflected light reflected from the membrane portion the cell, the reflected light including spectroscopic information indicative of whether the cell is noncancerous or cancerous.

Abstract: Incorporation of deuterium into the lipids, proteins, and/or genetic material in cells, tissues, organs, or organisms, including animals, such as humans, and plants, by administration of heavy water, allows for the spectral determination of levels of lipids, proteins, and/or genetic material using Raman spectroscopy, such as stimulated Raman spectroscopy. Following administration of a drug, changes in the relative amounts of lipid, protein, and/or genetic materials can be determined, and the efficacy, or lack thereof, of the administered drug can be determined.

Abstract: An object recognition apparatus includes a first spectrometer configured to obtain a first type of spectrum data from light scattered, emitted, or reflected from an object; a second spectrometer configured to obtain a second type of spectrum data from the light scattered, emitted, or reflected from the object, the second type of spectrum data being different from the first type of spectrum data; an image sensor configured to obtain image data of the object; and a processor configured to identify the object using data obtained from at least two from among the first spectrometer, the second spectrometer, and the image sensor and using at least two pattern recognition algorithms.

Abstract: Described herein is a spectrometer device for optical analysis of at least one sample. The spectrometer device includes: at least one housing having at least one entrance window; at least one wavelength-selective element configured for separating incident light into a spectrum of constituent wavelengths, the wavelength-selective element being disposed within the housing; at least one detector device configured for detecting at least a portion of the constituent wavelengths, the detector device being disposed within the housing; and at least one contact sensor device for detecting a contact of the spectrometer device with the sample, where the contact sensor device includes at least one optical contact sensor device, where the optical contact sensor device is configured to detect an influence of the presence of the sample onto the transmission of the optical signal.

Abstract: A surface-enhanced Raman scattering (SERS)-active electrode include a solid support; a porous oxide layer containing transition metal oxide nanoparticles present on a surface of the solid support and has a mean pore size of 2 to 30 nm; and at least one of noble metal nanoneedles and noble metal nanorings present on the porous oxide layer. The noble metal nanoneedles have an average length of 350-800 nm, a flat end with an average width in a range of 100-150 nm, and a pointed end. The noble metal nanorings have a thickness of 50-300 nm and are present in the form of annular clusters having various elliptical shapes with an average diameter in a range of 35-60 nm.

Abstract: A hand-held sized imaging instrument identifies molecules with high selectivity and in complex mixtures. The instrument uses inelastic scattering and scattering intensities from with machine learning algorithms based on convolutional neural networks (CNN's) to identify the presence of a specified chemical or combination of chemicals. A laser is housed within the instrument to initiate a material response of a sample using laser light of a specified wavelength. The instrument uses an image sensor to capture visible images with inelastic scattering information. The CNN is able to classify the image to determine whether the specified chemical or combination of chemicals is present in the sample. The instrument is inexpensive, portable, easy to use by anyone (nonchemist, nonprofessional), and safe (laser is completely housed). The instrument can be used efficiently and easily for quality control, security, and other applications to reliably detect the presence of specified substances.

Abstract: Each pixel of a plurality of pixels captures a portion of outgoing light illuminating a local area reflected from the one or more objects in the local area. A flag is generated via a flag determination logic circuit coupled to each pixel of the plurality of pixels. The flag indicates whether the reflected light was captured within a threshold amount of time from a current time. A time to digital converter is enabled via a flag determination logic circuit. The time to digital converter is associated with each pixel of the plurality of pixels to generate a digital representation of time when each pixel of the plurality of pixels captured the reflected light. Depth information is determined for the one or more objects in the local area based in part on the generated flag and the digital representation of time.

Abstract: A full-field microscopy method for detection of Brillouin-scattered light includes illuminating a two-dimensional plane in a sample with interrogating light having a first wavelength. Light emitted from the two-dimensional plane can be collected. The emitted light comprises Brillouin-scattered light resulting from interaction of the interrogating light with the sample. The Brillouin-scattered light can have a second wavelength shifted from the first wavelength. The collected light can be passed through a spectrally-selective assembly comprising a gas or vapor illuminated by pumping light. After the spectrally-selective assembly, the Brillouin-scattered light from multiple points in the two-dimensional plane in the sample can be simultaneously detected by an electro-optical sensor. In some embodiments, the spectrally-selective assembly can be altered by changing a wavelength or polarization of the pumping light to allow acquisition of a Brillouin spectrum.

Abstract: Improved stimulated Raman spectroscopy is provided by replacing the Stokes (or anti-Stokes) optical source with a localized electromagnetic emitter that is excited with a non-electromagnetic excitation. Such a localized emitter can be an efficient Stokes (or anti-Stokes) source for stimulated Raman spectroscopy, and can also provide deep sub-wavelength spatial resolution. In a preferred embodiment, an electron beam from an electron microscope is used to excite the localized emitter. This provides combined Raman imaging and electron microscopy that has the two imaging modalities inherently registered with each other.

Abstract: The invention generally relates to improved enhancement structures for use in surface-enhanced Raman scattering (SERS) and/or surface-enhanced fluorescence-based analysis.

Abstract: Disclosed herein are systems and methods of obtaining a derivative Raman spectrum using an excitation or Raman pump beam whose wavelength is modulated in any suitable manner such as, for example, stochastically. Shifting the wavelength of the input excitation by a small amount in approaches like SERDS can isolate the Raman scatter from other spectral artifacts and reduce the false detection rate. For example, an input excitation sequence can be correlated with the response of an individual pixel of a detector. From this, pixels that have captured Raman scattered photons can be separated from pixels capturing non-Raman photons. These techniques can be expanded to other fields and/or types of spectroscopies that utilize a dispersive element detector with time-dependent spectral features.

Abstract: In one aspect, molecular sensors and methods of making molecular sensors are described herein. In some embodiments, such a sensor comprises a first layer having a dual nanohole structure and a second layer having at least one nanopore. In some embodiments, the first and second layer define a chip of the sensor. In another aspect, methods of sensing are described herein, which in some embodiments comprise (i) providing a test sample comprising complexed and/or non-complexed biomolecules; (ii) contacting the test sample with the first layer of the molecular sensor; (iii) irradiating the dual nanohole structure of the sensor with a beam of electromagnetic radiation; (iv) optically trapping the biomolecules in the dual nanohole structure and measuring a surface plasmon resonance; (v) applying an electric field across the nanopore of the sensor; and (vi) measuring change in current across the nanopore during one or more translocation events of the biomolecules.

Abstract: A crosslinked fluoropolymer resin is configured to include a measuring step of irradiating a surface of the crosslinked fluoropolymer resin with a laser to measure a Raman spectrum, and an acceptance or rejection decision step of determining an acceptance or a rejection of a quality of a measurement region irradiated with the laser, on the basis of an intensity of a fluorescence spectrum relative to an intensity of a Raman scattering peak, which is ascribed to a CF2 stretching vibration, in the measured Raman spectrum.

Abstract: A laser device comprises a first optical cavity comprising a first gain medium and a second optical cavity comprising a second gain medium. The first gain medium and the second gain medium generate light at respective different ranges of wavelengths. A synchronizer is optically coupled to both the first optical cavity and the second optical cavity and is configured to synchronize and mode-lock light from the first optical cavity and the second optical cavity. The laser device also includes a first optical filter and a second optical filter to filter the light from the first optical cavity and the second optical cavity respectively to output first filtered light pulses at a first predetermined range of wavelengths and second filtered light pulses at a second predetermined range of wavelengths.

Abstract: An information processing device acquires an image captured by a transmission electron microscope. The information processing device, for each partial region in the image, executes a two-dimensional Fourier transform on an image of the partial region. The information processing device, based on results obtained by executing the two-dimensional Fourier transform on each of the partial regions, performs clustering of frequency strengths obtained from the results of the two-dimensional Fourier transform. The information processing device determines regions of different crystallinity in the image, based on results of the clustering.

Abstract: An optical measurement probe for capturing a spectral response through an intervening material emitting unwanted background radiation includes: a first lens configured to receive light and collimate the light into a collimated excitation beam defining a first aperture; an objective element for focusing the collimated excitation beam to a point or region in a sample through the intervening material, wherein the objective element also receives light scattered by the sample and the intervening material and collimates the scattered light into a collimated collection beam defining a second aperture; and a blocking element within the collimated collection beam for removing the light scattered by the intervening material from the collimated collection beam received from the sample, wherein the second aperture defined by the collimated collection beam is at least two times greater than the first aperture defined by the collimated excitation beam.

Abstract: Embodiments herein describe spectroscopy systems that use an unmodulated reference optical signal to mitigate noise, or for other advantages. In one embodiment, the unmodulated reference optical signal is transmitted through the same vapor cell as a modulated pump optical signal. As such, the unmodulated reference optical signal experiences absorption by the vapor, which converts laser phase noise to amplitude noise like the other optical signals passing through the vapor cell. In one embodiment, the unmodulated reference optical signal has an optical path in the gas cell that is offset (or non-crossing) from the optical path of the modulated pump optical signal. The unmodulated reference optical signal allows removal or mitigation of the noise on the other optical signal.

Abstract: Method for characterising a microorganism, comprising: —illuminating, in the wavelength range of 390 nm-900 nm, the microorganism having a natural electromagnetic response in said range; —acquiring, in said range, a light intensity reflected by said (or transmitted through said) illuminated microorganism; and —determining the microorganism as being a yeast or a bacterial strain according to the light intensity acquired in said range.

Abstract: Raman systems and methods use advantages offered by increased laser mobility/path length and photon migration to analyze diffusively scattering solids, including pharmaceuticals. A collimated laser excitation beam having a first diameter induces from a sample a backscattered collimated Raman collection beam with a second diameter. The collimated laser excitation beam and the collimated Raman collection beam form a counter-propagating collimated optical path, and the collimated laser excitation beam is preferably smaller in diameter than the diameter of the backscattered collimated Raman beam. The collection beam to a spectrograph for Raman analysis of the sample. A Raman calibration standard may be placed in the collimated optical path, and/or the sample may be supported in a reflective holder that may be at least partially spherical and/or may form part of a multi-well plate. The counter-propagating collimated optical path may be contained within a Raman microscope.

Abstract: An assembly including a non-linear element configured for generating broadband radiation from input radiation coupled into the non-linear element. The assembly further includes an optical element positioned downstream of the non-linear element configured to reflect a fraction of the broadband radiation back into the non-linear element. The non-linear element can be a nonlinear fiber, such as a hollow-core photonic crystal fiber (HC-PCF).

Abstract: A spectroscopic detector comprises a first housing, a second housing, a camera lens housed in the first housing, and an image sensor housed in the second housing. The first housing has a first through hole formed therein. The second housing has a second through hole formed therein. The second housing is attached to the first housing so as to allow for communication between an inside of the second housing and an inside of the first housing via the first through hole and the second through hole. In a state where the second housing is attached to the first housing, a periphery of the second through hole is located inside a periphery of the first through hole.

Abstract: A Raman spectroscopy apparatus using a nano printing device is provided to perform Raman spectroscopy on nanoscale nanostructures printed from the nano printing device. The Raman spectroscopy apparatus includes a laser light source configured to generate and emit a laser light to the nanostructures, and a Raman detector configured to collect spectroscopic information from the light scattered by the nanostructures.

Abstract: Quantum entanglement protection is disclosed. An entanglement checker receives, from a requestor, a request associated with a first qubit. In response to receiving the request, the entanglement checker accesses qubit entanglement information that identifies an entanglement status of the first qubit. The entanglement checker determines, based on the qubit entanglement information, the entanglement status of the first qubit, and sends a response to the requestor based on the entanglement status.

Abstract: A sample measurement device includes: a sample container that stores a sample solution; a light source that irradiates the sample container with irradiation light from a first direction; an imaging part that captures an image of the sample solution based on light scattered by the sample solution from a second direction intersecting the first direction; and a calculator that calculates an absorbance or a concentration of the sample solution based on the image. The calculator calculates a degree of attenuation of a light amount of the image at a constant optical path length along the first direction based on the image, and calculates the absorbance or concentration of the sample solution according to the degree of attenuation.

Abstract: The multi-photon microscope comprises a repetition rate tuner that lowers an optical pulse train emitted from a pulsed laser to a repetition rate for time-gated detection, a scanner that scans the optical pulse train transmitted from the repetition rate tuner in x-axis and y-axis directions, an objective lens that irradiates an optical signal scanned by the scanner to the sample and acquires a fluorescence signal emitted from the excited fluorescent material, a photodetector that photoelectrically converts the fluorescence signal acquired by the objective lens, an amplifier that converts a current signal output from the photodetector into a voltage signal, a digitizer that samples the voltage signal output from the amplifier, and a computing device that separates sampling data output from the digitizer with a detection window set in time domain, and generates an image based on the sampling data separated by the detection window.

Abstract: To provide an article inspection apparatus capable of sensitively and stably detecting a change in a spectrum when an unspecified foreign substance is contained and determining a defective product. A transport unit that transports a tablet for inspection to an article inspection position, a light irradiation unit that irradiates the tablet transported to the article inspection position with light, a light detection unit that detects light transmitted through the tablet, and an article inspection unit that inspects a quality of the tablet based on spectral characteristics of the light detected by the light detection unit are provided, and the article inspection unit standardizes a measured value of a spectrum of the light detected by the light detection unit for each wavelength and determines whether the tablet is a normal product or a defective product based on a standardized value.

Abstract: An apparatus for disruption of tissue. The apparatus includes a housing; a source of pulsed laser radiation; and an optical waveguide. The optical waveguide is configured to transmit the pulsed laser radiation from the source of pulsed laser radiation, and is coupleable to the source of pulsed laser radiation at a proximal end of the optical waveguide to receive the pulsed laser radiation from the source of pulsed laser radiation. The apparatus also includes a driving mechanism coupled to the optical waveguide for controllably changing the position of the optical waveguide relative to a distal end of the housing.

Abstract: A device for performing Raman spectroscopy measurements that incorporate Raman Shift calibration and related method for carrying out the Raman Shift calibration are disclosed. The device comprises of one or more Raman shift reference materials with one or more Raman bands, the positions of which are pre-determined to a high degree of accuracy within a useful temperature range. The device further comprises a sensor to measure the temperature of the one or more reference materials to provide accurate reference values for the Raman shift calibration. When used with the measured spectrum of the reference materials, an accurate Raman Shift calibration function of the device can be generated.

Abstract: Disclosed are a system and method for active stabilization of parasitic fringes in optical spectrometers, wherein the spectrometer obtains the transmission spectrum, and a signal processor extracts the etalon drift from the spectral signatures of parasitic fringes. The disclosed approach improves spectrometer accuracy, minimizes drift, and increases time between calibrations.

Abstract: An optical calibration tool includes a first body, a light emitter, a light receiver, a second body, and a light reflecting member. The first body has a first engaging port and a second engaging port. The light emitter and the light receiver are disposed in the first body. The second body has a third engaging port and a channel communicated with each other. The third engaging port is configured to selectively engage one of the first engaging port and the second engaging port. When the third engaging port is engaged with the first engaging port, the light emitter is optically coupled to the light reflecting member. When the third engaging port is engaged with the second engaging port, the light receiver is optically coupled to the light reflecting member.

Abstract: An embodiment of a module system configured to interface with a microscope is described that comprises an input optical fiber configured to provide an excitation light beam from an external light source; dynamic alignment mirrors configured to adjust the position of the beams paths of the excitation light beam on a first plane; a coupling comprising a first end configured to engage with a complementary end, wherein the excitation light reflects off a turning mirror and travels along a beam path on a second plane through an orifice in the coupling; and an output optical fiber for delivering light from a sample to an external detector, wherein the light from the sample travels along the beam path on the second plane through the orifice in the coupling, reflects off the turning mirror and travels along one of the beam paths on the first plane to the output optical fiber.

Abstract: A device for the detection of analytes comprises a substrate (10) with nano-antennas (11,12). The nano-antennas (11,12) comprise an antenna material (11m, 12m) for forming resonant antenna structures which receive and resonantly interact with source light (L0) to form respective resonance peaks (R1,R2) over a resonant wavelength range (A1,A2) overlapping respective signature wavelength (?1,?2) of a target analyte (A). The resonant interaction causes a locally concentrated field (Ec) of the source light (L0) in the resonant wavelength range (?1,?2). The concentrated intensity (Ic) is localized around a respective target location (T1,T2) which is provided with a sorption material (11s, 12s) that sorbs the target analyte (A). This provides a locally increased analyte concentration (Ac) of the target analyte (A) coinciding with the locally concentrated field (Ec) of the source light (L0). Accordingly, the interaction of the source light (L0) with the target analyte (A) is enhanced.

Abstract: An integrated device for the detection of cancerous tissue including an optical fiber configured to receive at a first end modulated infrared light and to conduct the modulated infrared light from the first end to a second end; and a plasmonic metasurface, disposed on the second end of the optical fiber, configured to localize evanescent infrared light to sub-I 00 nanometer distances from the plasmonic metasurface of the optical fiber such that the localized evanescent infrared light penetrates only the membrane portion of a cell held against the second end, wherein the second end is configured to receive reflected light reflected from the membrane portion the cell, the reflected light including spectroscopic information indicative of whether the cell is noncancerous or cancerous.