With Raman Type Light Scattering Patents (Class 356/301)
  • Patent number: 11320379
    Abstract: A surface enhanced luminescence (SELS) sensor may include a substrate and nano fingers projecting from the substrate. Each of the nano fingers may include a polymer pillar having a sidewall and a top, a coating layer covering the sidewall and a metal cap supported by and in contact with the top of the pillar.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: May 3, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Ning Ge, Milo Overbay, James Abbott, Anita Rogacs, Viktor Shkolnikov
  • Patent number: 11313725
    Abstract: State-of-the-art portable Raman spectrometers use discrete free-space optical components that must be aligned well and that don't tolerate vibrations well. Conversely, the inventive spectrometers are made with monolithic photonic integration to fabricate some or all optical components on one or more planar substrates. Photonic integration enables dense integration of components, eliminates manual alignment and individual component assembly, and yields superior mechanical stability and resistance to shock or vibration. These features make inventive spectrometers especially suitable for use in high-performance portable or wearable sensors. They also yield significant performance advantages, including a large (e.g., 10,000-fold) increase in Raman scattering efficiency resulting from on-chip interaction of the tightly localized optical mode and the analyte and a large enhancement in spectral resolution and sensitivity resulting from the integration of an on-chip Fourier-transform spectrometer.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: April 26, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Tian Gu, Derek Kita, Juejun Hu
  • Patent number: 11313721
    Abstract: A compact spectrometer includes an excitation light source configured to generate excitation light and arranged to illuminate a spot on a sample. A dispersive element includes at least one movable component and spatially separates output light emanating from the sample in response to the excitation light into a plurality of different wavelength bands. A moveable component of the dispersive element causes the plurality of different wavelength bands of the output light to be scanned across a detector. The detector includes at least one light sensor that senses the wavelength bands of the output light and generates an output electrical signal in response to the sensed output light.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: April 26, 2022
    Assignee: Oak Analytics
    Inventors: Ruibo Wang, Pawel Adam Menzfeld
  • Patent number: 11307091
    Abstract: A hard-apertureless spectrometer includes a housing, a collimator configured to collimate light provided from a soft-aperture of a target, a diffraction grating configured to spectroscopically analyze the collimated light, a condenser configured to condense the spectroscopically analyzed light, and a photodetector configured to receive the condensed light output from the condenser and detect a target characteristic.
    Type: Grant
    Filed: November 27, 2020
    Date of Patent: April 19, 2022
    Assignee: Answeray Inc.
    Inventors: Seong Ho Cho, Gajendra Pratap Singh
  • Patent number: 11300448
    Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: April 12, 2022
    Assignee: Pendar Technologies, LLC
    Inventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
  • Patent number: 11293920
    Abstract: A method for making a plasmonic mushroom array includes: forming a plurality of metal nano-islands each having nanometer-range dimensions on a surface of a glass substrate; and subjecting to the glass substrate having the plurality of metal nano-islands formed thereon to reactive ion etching such that the plurality of metal nano-islands are converted to a plurality of mushroom-shaped structures each having a metal cap supported by a pillar made of a material of the glass substrate and each having dimensions smaller than the dimensions of the nano-islands, the plurality of mushroom-shaped structures being arranged in a substantially regular pattern with intervals smaller than average intervals between the nano-islands, thereby forming the plurality of nano-scale mushroom-shaped structures on the glass substrate that can exhibit localized surface plasmon resonance.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: April 5, 2022
    Inventors: Nikhil Bhalla, Amy Shen Fried, Kang-Yu Chu
  • Patent number: 11287381
    Abstract: A chlorophyll fluorescence measuring system having at least one spectrometer coupled to a data logger. The data logger provides direct control of the spectrometer and includes on-board memory for storage of target and reference spectrum data obtained by the spectrometer. The data logger may be coupled to an external computer that receives and analyzes target and reference spectrum data to determine SIF using a spectral fitting algorithm. The system may include a spectrometer aiming system coupled to and controlled by the data logger. The system may also include one or more environmental sensors configured to measure environment variables. The environmental sensors may be coupled to the data logger for control and data storage. The environmental data may be communicated to the external computer for use in the spectral fitting algorithm. The data logger may be connected to a network for remote monitoring and control.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: March 29, 2022
    Assignee: UT-BATTELLE, LLC
    Inventors: Lianhong Gu, Jeffrey S. Riggs
  • Patent number: 11287383
    Abstract: A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer, and an optical system for coupling light from the optical source to a sample and for coupling light from the sample to the spectrometer and a further spectrometer. A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer and an optical system for coupling light from the optical source and a further optical source to a sample and for coupling light from the sample to the spectrometer. The optical system may be configured for coupling light from the optical source and the further optical source to the sample and for coupling light from the sample to the spectrometer and the further spectrometer. The Raman system may be portable and/or may be configured to be transported and/or carried and/or may be handheld.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: March 29, 2022
    Inventors: Kishan Dholakia, Mingzhou Chen
  • Patent number: 11280675
    Abstract: A chip-based planar Raman spectroscopic measurement system is disclosed comprising at least a semiconductor laser as excitation light source, an output waveguide coupling and delivering laser light out of chip, a photo-detector monitoring the laser optical power, an input waveguide coupling signal light to chip, a planar spectrometer comprising Planar Waveguide Grating (PWG) and an array photo-detectors, and control electronics. In some embodiments the PWG is a fixed frequency Arrayed Waveguide Grating (AWG), the laser is frequency-tunable. In other embodiments, the laser has fixed frequency, the PWG or the AWG is frequency tunable. In either case, the frequency tunability will ensure the recapture of the spectral information missed due to the spectral characteristics of the planar waveguide grating such as the channel spacing of the AWG, resulting in high channel count and high-resolution Raman measurement of sufficient spectral range.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: March 22, 2022
    Inventors: Ruolin Li, Yanan Ma
  • Patent number: 11280738
    Abstract: This invention relates to a method and apparatus for the early detection and monitoring of colorectal cancer via the sampling of a patient's blood.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: March 22, 2022
    Assignee: Swansea University
    Inventors: Dean Harris, Peter Dunstan, Cerys Jenkins
  • Patent number: 11274963
    Abstract: A measuring device for time-resolved measurement of a measurement signal and for temporal separation of at least a first portion of the measurement signal, having a light source for emitting a pulsed excitation signal, at least one detector for receiving the measurement signal, the detector generating a detector signal from the measurement signal, at least one first forming unit for generating a first comparison signal, and at least one evaluation unit, the first comparison signal correlating with the excitation signal. At least one first logic function is provided which links at least the first comparison signal with a signal dependent on the detector signal so that the output of the logic function provides a measure of the intensity of the first portion of the measurement signal or of the detector signal. The output of the first logic function is connected to the at least one evaluation unit.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: March 15, 2022
    Inventors: Jan Tebrügge, Jan Förster, Thomas Fritsch
  • Patent number: 11274967
    Abstract: A multi-analyte sensor system based on hollow core photonic bandgap fiber and Raman anti-Stokes spectroscopy. The system includes: i) an inlet to introduce an analyte sample into an analyzer chamber which analyzer includes; ii) a measurement system to derive the anti-Stokes spectral peaks and/or spectra of the sample; iii) a set of reference calibrants corresponding to the analytes of which the sample is primarily comprised; iv) a second inlet to introduce said calibrants into the analyzer chamber; v) a second measurement system to derive the anti-Stokes spectral peaks and/or spectra of the calibrants vi) an outlet through which the sample and calibrants are expelled from the analyzer chamber.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: March 15, 2022
    Assignee: Finesse Solutions, Inc.
    Inventors: Mark Selker, Barbara Paldus
  • Patent number: 11268942
    Abstract: The invention relates to a test device (10) for analysing, more particularly for detecting, non-destructively, pressure and temperature, and preferably for detecting a gas concentration in foodstuffs (50.4) contained in packaging (50), the test device having: —a detection assembly (30) for detecting at least one parameter in a foodstuff (50.4) contained in packaging (50), the parameter being specific to a property to be examined of the foodstuff (50.4). According to the invention, the test device (10) is designed as a hand-held device.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: March 8, 2022
    Assignee: Steinfurth Mess-Systeme GmbH
    Inventors: Johann Angres, Martin Falkenstein
  • Patent number: 11269111
    Abstract: The disclosure relates to a gravity gradiometer including a pair of magneto-optical traps for measuring a gravity gradient. A cold atom gravity gradiometer system includes comprising: first and second magneto-optical traps, each having a plurality of mirrored surfaces arranged to reflect an incident laser beam to trap respective first and second cold atom clouds separated from each other by a separation distance; an optical subsystem arranged to transmit a first laser beam in a first direction along a first longitudinal axis towards the first magneto-optical trap and a second laser beam in an opposite second direction along a second longitudinal axis towards the second magneto-optical trap, the second longitudinal axis being parallel to the first longitudinal axis.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: March 8, 2022
    Inventors: Andrew Lamb, Geoff De Villiers, Michael Holynski, Kai Bongs
  • Patent number: 11262284
    Abstract: A particle counter includes: a multi-flow cell with flow passages arrayed in a first direction and having a section including a detection region, for detecting a particle, formed when the flow passage is irradiated with irradiation light; a light receiving optical system configured to receive emitted light generated from a particle contained in sample fluid flowing in the at least one flow passage and passing through the detection region; an optical axis moving unit configured to move an optical axis of the irradiation light and an optical axis of the emitted light in the first direction; and a counter configured to count the particle for each particle size based on an intensity of the emitted light.
    Type: Grant
    Filed: January 20, 2020
    Date of Patent: March 1, 2022
    Assignee: RION Co., Ltd.
    Inventors: Tomonobu Matsuda, Takashi Minakami, Daisuke Sakaue, Daisuke Shinozaki
  • Patent number: 11249057
    Abstract: Systems and methods are described to provide speciation of silicon species present in a remote sample for analysis. A method embodiment includes, but is not limited to, receiving a fluid sample containing inorganic silicon in the presence of bound silicon from a remote sampling system via a fluid transfer line; transferring the fluid sample to an inline chromatographic separation system; separating the inorganic silicon from the bound silicon via the inline chromatographic separation system; transferring the separated inorganic silicon and bound silicon to a silicon detector in fluid communication with the inline chromatographic separation system; and determining an amount of one or more of the inorganic silicon or the bound silicon in the fluid sample via the silicon detector.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: February 15, 2022
    Inventors: Jacob Unnerstall, Patrick Sullivan, Daniel R. Wiederin, Brad Prucha, Charles Derrick Quarles, Jr., Jae Seok Lee
  • Patent number: 11237112
    Abstract: A surface enhanced Raman spectroscopy (SERS) device, comprises a non-electrically conductive substrate, at least two microelectrodes disposed on the substrate in a spaced relationship such that a detection site is formed along edges and/or between opposing edges of the microelectrodes, and a nanoparticle structure comprising a plurality of metallic nanoparticles disposed in the detection site. Assembly of the nanoparticle structure may be directed by an electric field between the at least two microelectrodes. The SERS device is inexpensive, robust, portable, and reusable. Also described herein are methods for using and preparing the SERS devices with simple, rapid, and inexpensive fabrication techniques.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: February 1, 2022
    Assignee: Queen's University at Kingston
    Inventors: Hannah Bacon, Aristides Docoslis, Carlos Escobedo
  • Patent number: 11231371
    Abstract: A method for the determination of antibiotic susceptibility through stimulated Raman scattering microscopy is disclosed. The method utilizes a imaging apparatus adapted to collect a laser signal through a sample having a bacteria for imaging the metabolism of the sample. The sample can be manipulated with an antibiotic for imaging to determine the susceptibility of a bacteria to the provided antibiotic.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: January 25, 2022
    Inventors: Ji-xin Cheng, Mohamed Seleem, Weili Hong
  • Patent number: 11215751
    Abstract: A preform (10) for an antiresonant hollow core optical fibre comprises an outer jacket tube (12) having an inner surface and a central longitudinal axis (24); a plurality of antiresonant cladding tubes (14) spaced apart at predefined peripheral locations around the inner surface of the outer jacket tube (12), each antiresonant cladding tube (14) in contact with the inner surface such that a central longitudinal axis (26) of each antiresonant cladding tube (14) is at a first radial distance from the central longitudinal axis (24) of the outer jacket tube (12); and a plurality of spacing elements (22) disposed alternately with the antiresonant cladding tubes (14) and each in contact with an outer surface of each of two adjacent antiresonant cladding tubes (14) at one or more contact points (28), the contact points (28) at a second radial distance from the central longitudinal axis (24) of the outer jacket tube (12), the second radial distance being greater than the first radial distance.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: January 4, 2022
    Assignee: University of Southampton
    Inventors: Francesco Poletti, Gregory Teofil Jasion, Natalie Wheeler, Thomas David Bradley, Mubassira B Syed Nawazuddin, John Hayes
  • Patent number: 11215561
    Abstract: A method for automated, in-line measurement of a differentiated surface cleanliness, in terms of carbon, of a continuously-moving metal sheet or strip, having a level of surface carbon pollution lower than 100 mg/m2, includes: generating a radiation beam using a source; focusing the radiation beam using a focusing device such that an energy density deposited on the metal strip or sheet is sufficient to create a plasma and generate CN radicals in the plasma if carbon and nitrogen are present; creating a nitrogen atmosphere around the plasma using a sweeping system with a flow rate that prevents any presence of oxygen from air in the plasma; analyzing light emitted by the plasma using an optical collection device, and redirecting the light toward a spectrometer or device for separating wavelengths of the emitted light; measuring an intensity of an intense vibration line of the CN radical.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: January 4, 2022
    Inventors: Guy Monfort, Genevieve Moreas
  • Patent number: 11204322
    Abstract: Measurement device for the detection and/or characterization of fluid-borne particles featuring a laser positioned for emitting pulses of laser light polarized in a first direction, in a measurement volume of a fluid flow path, each pulse having a pulse duration, and a means for directing the laser pulses polarized in a second different direction of polarization in the measurement volume. An optical spectrometer captures fluorescent light emitted by individual fluid-borne particles and measures the intensity of at least one wavelength at a sampling rate of at least three samples per pulse. The means for directing are configured to direct laser light polarized in the second direction each time a pulse of laser light crosses the measurement volume, the time delay between the two crossings being longer than the pulse duration and shorter than a travel time of the fluid in the measurement volume.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: December 21, 2021
    Assignee: Plair S.A.
    Inventors: Denis Kiselev, Svetlana Kiseleva
  • Patent number: 11199499
    Abstract: A surface enhanced luminescence analyte interrogation stage may include a substrate and an array of pillars projecting from the substrate. Each of the pillars may include a polymeric post formed from a first material and a cap on the polymeric post. The cap has a plasmonic surface and is formed from a second material different than the first. A sacrificial coating covers the cap of each of the pillars.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: December 14, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Milo Overbay, Anita Rogacs, Devin A. Mourey
  • Patent number: 11199496
    Abstract: A method of measuring a polarization response of a sample (1), in particular a biological sample, comprises the steps of generating a sequence of excitation waves (2), irradiating the sample (1) with the sequence of excitation waves (2), including an interaction of the excitation waves (2) with the sample (1), so that a sequence of sample waves (3) is generated each including a superposition of a sample main pulse and a sample global molecular fingerprint (GMF) wave (EGMF(sample)(t)), irradiating a reference sample (1A) with the sequence of excitation waves (2), including an interaction of the excitation waves (2) with the reference sample (1A), so that a sequence of reference waves (3A) is generated each including a superposition of a reference main pulse and a reference GMF wave (EGMF(ref)(t)), optically separating a difference of the sample waves (3) and reference waves (3A) from GMF wave contributions which are common to both of the sample waves (3) and reference waves (3A) in space and/or time, and detec
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: December 14, 2021
    Assignees: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V., Ludwig-Maximilians-Universitaet Muenchen
    Inventors: Ferenc Krausz, Hanieh Fattahi, Marinus Huber, Joachim Pupeza, Mihaela Zigman Kohlmaier
  • Patent number: 11193879
    Abstract: An apparatus for sorting cells includes a measurement volume that contains a cell to be measured, a light source that provides light to cause an emission by a fluorescent label attached to the cell, and an optic device that directs the light through the measurement volume. The apparatus flows the cells through the measurement volume such that as the cell flows through the measurement volume, it interacts with the light, resulting in a change in light originating from the measurement volume, the change in light is a fluorescence emission. Another optic device directs a portion of the light originating from the measurement volume to a detector, which detects the portion of the light. A processor operably coupled to the detector generates an estimate of DNA quantity in the cell based on the change in light originating from the measurement volume, and determines a characteristic of the cell from the estimate.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: December 7, 2021
    Assignee: 1087 SYSTEMS, INC.
    Inventors: Matthias Wagner, John Heanue
  • Patent number: 11187652
    Abstract: A method of investigating a sample (1) having an absorption within an infrared spectral range of interest, comprises the steps of creating measuring light (2) with a light source device (10), wherein the measuring light (2) includes wavelengths covering the infrared spectral range, directing the measuring light (2) through the sample (1) to a detector device (20) with a plurality of detector units (21), each of which comprising an infrared sensitive sensor section (22) and an associated metamaterial resonator section (23) having a specific spectral resonance line (3), wherein the spectral resonance lines (3) of the resonator sections (23) have different frequencies within the infrared spectral range, wherein the measuring light (2) is transmitted through the sample (1) to the resonator sections (23) and subsequently sensed by the sensor sections (22), wherein an output of each of the sensor sections (22) depends on the absorption of the sample (1) at the frequency of the spectral resonance line (3) of the ass
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: November 30, 2021
    Inventors: Hatice Altug Yanik, Andreas Tittl, Aleksandrs Leitis
  • Patent number: 11181480
    Abstract: A method for identifying minerals and other materials illuminates a mineral with monochromatic light for an illumination duration and a true Raman spectrum is determined. The true Raman spectrum data is compared to reference spectrums to identify the mineral or material by calculating an identification score for each reference Raman spectrum relative to the Raman spectrum data of the unknown material using a formula that includes both a coincident-peak term and a missing-peak-penalty term.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: November 23, 2021
    Inventor: Paul Bartholomew
  • Patent number: 11181423
    Abstract: A measurement system of photoluminescence properties of a sample, comprises a radiation source module configured to generate a first radiation, an excitation optical path coupled to the radiation source module, a support structured to support a sample to be optically coupled to excitation optical path and adapted to provide a photoluminescence radiation, and collection path coupled to the sample and configured to propagate the photoluminescence radiation. The system also includes an analysis device configured to receive the photoluminescence radiation and provide data/information on photoluminescence properties of sample. At least one path between the excitation path and the collection path comprises a respective adjustable birefringent common-path interferometer module configured to produce first and second radiations adapted to interfere with each other.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: November 23, 2021
    Assignee: Politecnico di Milano
    Inventors: Dario Polli, Giulio Cerullo, Fabrizio Preda, Antonio Perri, Jürgen Hauer
  • Patent number: 11175225
    Abstract: A method for measuring one or more quantities characterizing a composition of a medium includes causing a first non-uniform spatially varying optical signal to impinge on a portion of the medium, processing a second optical signal emitted from the medium in response to the first optical signal including determining characteristics of a spatial variation of the second optical signal, and determining the one or more quantities characterizing the composition of the medium based on the characteristics of the spatial variation of the second optical signal.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: November 16, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Sanjay E. Sarma, Pranay Jain
  • Patent number: 11175128
    Abstract: The present invention relates to devices and methods for detecting the amount (degree, extent) of material coating a medical device or substrate, in particular the present invention relates to devices and methods for detecting the amount of vaccine material coating a microarray patch.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: November 16, 2021
    Inventors: Michael Carl Junger, Christopher Flaim
  • Patent number: 11175232
    Abstract: Standoff ultra-compact micro-Raman sensors configured to receive Raman scattering from a substance are disclosed. A laser device may be configured to transmit a laser at a first wavelength. The laser may be expanded to a predetermined size, focused through a lens, and made incident on an unknown substance. A filter may reflect the laser and Rayleigh scattering from the substance, but may permit Raman scattering and laser-induced fluorescence from the substance. One or more lenses and/or filters may receive and pass the Raman scattering and/or laser-induced fluorescence to a light sensor. The received Raman scattering and/or laser-induced fluorescence may be compared to known fingerprints of substances to determine an identity of the substance. The wavelength of the laser, the width of the laser, and other parameters may be varied based on the distance between the standoff ultra-compact micro-Raman sensor and the substance.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: November 16, 2021
    Inventors: M. Nural Abedin, Arthur T. Bradley, Anupam Kumar Misra, Yingxin Bai
  • Patent number: 11150191
    Abstract: An apparatus comprises: a photonic cavity; a substrate comprising a waveguide layer, wherein the waveguide layer comprises waveguides configured to direct light towards the photonic cavity; and a wafer comprising: a top side, and a nanowire array affixed to the top side. A method of performing a surface-enhanced Raman scattering (SERS) analysis, the method comprises: directing, using a waveguide layer of a SERS device, an incident light towards a photonic cavity of the SERS device; permitting, using the photonic cavity, a fluid to flow freely into and out of the SERS device; causing, within the photonic cavity, an interaction among the incident light, the fluid, and a nanowire array of the SERS device to create scattered light; converting the scattered light into an electrical signal; and analyzing the electrical signal to determine whether a contaminant exists in the fluid.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: October 19, 2021
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Binbin Weng, Mark A. Nanny, Joseph M. Suflita, Rouzbeh Ghanbarnezhad Moghanloo
  • Patent number: 11145411
    Abstract: A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: October 12, 2021
    Inventors: Patrick Treado, Shona Stewart, Heather Kirschner, Ryan Priore, Alan Wilson
  • Patent number: 11137245
    Abstract: Provided is a Raman spectroscopy method for simultaneously measuring a temperature and a thermal stress of a two-dimensional film material in situ. The method includes: providing the two-dimensional film material including a suspended part and a supported part and measuring Raman signals of the suspended part and the supported part; establishing equations of a Raman shift with temperature and a Raman shift with thermal stress for each of the suspended part and the supported part, and solving simultaneous equations to obtain coefficients with temperature and thermal stress; and scanning a characteristic Raman spectrum field of the two-dimensional film material and obtaining a temperature distribution and a thermal stress distribution of the two-dimensional film material according to the characteristic Raman spectrum field in combination of the coefficients of the Raman shift with temperature and the Raman shift with thermal stress.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: October 5, 2021
    Inventors: Xing Zhang, Haidong Wang, Hexin Liu
  • Patent number: 11137375
    Abstract: Systems and methods for focusing a light pulse within a focus area using nonlinear photoacoustic wavefront shaping (PAWS) are disclosed herein. The method includes modulating a spatial phase pattern of a light pulse's waveform based on a Grueneisen-relaxation photoacoustic (GR-PA) feedback signal. In addition, systems and methods for performing Grueneisen-relaxation photoacoustic microscopy (GR-PAM) are disclosed herein that include analyzing photoacoustic signals resulting from illumination of a focus region by two closely spaced light pulses. A method of obtaining an absorption coefficient of a sample using Grueneisen-relaxation photoacoustic microscopy (GR-PAM) is also disclosed.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: October 5, 2021
    Assignee: California Institute of Technology
    Inventors: Lihong V. Wang, Lidai Wang, Chi Zhang, Puxiang Lai, Jian Wei Tay
  • Patent number: 11125692
    Abstract: In a method of determining the type of each cell contained in a sample, one Raman spectrum is acquired from one undetermined cell, a plurality of degrees of matching of a Raman spectrum of the undetermined cell with respect to spectra of a plurality of principal components obtained by principal component analysis of a plurality of Raman spectra that are obtained one by one from each of a plurality of known types of cells are calculated, and a type of the undetermined cell is determined by classifying the plurality of degrees of matching based on a result obtained by classifying a plurality of principal component scores corresponding to each of the plurality of known types of cells obtained by the principal component analysis depending on the type of cells by a learning model using supervised learning.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: September 21, 2021
    Assignee: HORIBA, LTD.
    Inventors: Yoshito Okuno, Daisuke Irikura, Sakiko Akaji, Shiro Miyake
  • Patent number: 11125621
    Abstract: Embodiments of a system and a method for polarimetry using static geometric manipulation of the state of polarization are disclosed. According to one embodiment, a spectropolarimeter comprises a retarder having a geometrically changing fast axis. The fast axis changes along a polarimetric dimension. The spectropolarimeter has a polarization analyzer and a spectrographic optical platform. The spectrographic optical platform has a slit in a spatial dimension same as the polarimetric dimension of the retarder; a collimator; a dispersing element for dispersing spectral components of light received from the collimator along a spectral dimension that is perpendicular to the spatial dimension of the slit; a focusing optic; and a two-dimensional detector array. Using a quarter wave retarder full Stokes polarimetry can be provided though a half wave retarder can also be used.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: September 21, 2021
    Assignee: SETI INSTITUTE
    Inventor: William B. Sparks
  • Patent number: 11118974
    Abstract: A spectroscopic device is provided. The spectroscopic device includes a plurality of design groups on a substrate. Each design group includes a plurality of collapsed groups separated by bare regions of substrate, wherein the edges of each design group is configured to enhance the pinning of a solvent drying line at the edge of the design group. Each collapsed group comprises at least 2 flexible columnar structures, and each flexible columnar structure comprises a metal cap.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: September 14, 2021
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Steven Barcelo, Anita Rogacs
  • Patent number: 11119044
    Abstract: The method for determining the presence of a molecule having a Raman resonance generally comprises illuminating a sample with a first radiation beam, the first radiation beam having a first excitation wavelength being tuned to a Raman resonance of the molecule; receiving a first return signal from the sample following illumination of the sample with the first radiation beam; measuring a first intensity of the first return signal using an intensity detector; illuminating the sample with a second radiation beam, the second radiation beam lacking the first excitation wavelength and having a second excitation wavelength being different from the first excitation wavelength; receiving a second return signal from the sample following illumination of the sample with the second radiation beam; measuring a second intensity of the second return signal using an intensity detector; and determining the presence of the molecule in the sample based on the first and second intensities.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: September 14, 2021
    Inventor: François Babin
  • Patent number: 11119045
    Abstract: An apparatus for analyzing microbiome according to an embodiment of the inventive concept includes a light source unit configured to excite first light, a sample unit on which a sample to which the first light is incident is disposed, and a data analysis unit configured to receive second light emitted from the sample unit and analyze microbiome in the sample from the second light. Here, the sample unit includes a conductive polymer structure that surrounds the sample.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: September 14, 2021
    Inventors: Won Kyoung Lee, Bong Kyu Kim, Soo Jun Park, Chul Huh
  • Patent number: 11109781
    Abstract: Various embodiments of the invention provide systems and methods for low-cost, low-power Array Waveguide Grating (AWG)-based miniaturized Raman spectroscopy for use in non-invasive glucose monitoring systems, such as in wearable devices that require no replenishment of chemicals or enzymes. The AWG may be manufactured using VLSI processing technology, which significantly reduces manufacturing cost and replaces holographic grating as the dispersive component of light. In embodiments, the AWG is integrated with a number of PIN photodiode detectors on a substrate to further reduce cost and signal loss. In embodiments, a prism-coupling method eliminates alignment problems associated with traditional approaches that utilize fiber-coupling methods.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: September 7, 2021
    Inventors: Sheng Yang, Yen-Chun Yeh, Dominik Schmidt
  • Patent number: 11112331
    Abstract: A monitoring system is disclosed herein that is configured to utilize a distributed sensing system to monitor both a cable and cable accessories included within a cable circuit. In various embodiments, the monitoring system may include a distributed sensing system and one or more cable accessory wrap assemblies. The distributed sensing system may include a distributed sensing fiber following (or integrated into) the cable and connected to a cable accessory wrap assembly for each of the one or more cable accessories in-line with cable. In various embodiments, each cable accessory wrap assembly may comprise a cable wrap embedded with a distributed sensing fiber. The distributing sensing fiber of a cable accessory wrap assembly may be configured to provide measurements to distributed sensing system indicating that an anomaly event occurred at a given cable accessory.
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: September 7, 2021
    Assignee: Marmon Utility LLC
    Inventors: Rick Williamson, Michael P. Norton, Sergio Arellano
  • Patent number: 11105682
    Abstract: A system and method for imaging a sample using Raman spectrometry. Optical fibers having opposite first ends and second ends are arranged with the first ends and second ends in respective two-dimensional arrays. The two-dimensional arrays maintain relative positions of the optical fibers to one another from the first ends to the second ends in a way that the first end of each optical fibers of the bundle can simultaneously collect a corresponding Raman signal portion scattered from specific spatial coordinates of the area of the sample. The so-collected Raman signal portions are propagated towards the corresponding second end, from which are outputted and detected simultaneously using an array of detectors.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: August 31, 2021
    Inventors: Frederic Leblond, Karl St-Arnaud, Francois Daoust
  • Patent number: 11099073
    Abstract: An identification apparatus identifies the kind of an object to be conveyed by a conveyor and includes an illumination optical system illuminating the object with light from a light source, a light capturing optical system capturing Raman-scattered light from the object, a spectral element dispersing the Raman-scattered light, a light-receiving element receiving the Raman-scattered light dispersed by the spectral element, and a data-processing unit acquiring spectral data of the Raman-scattered light from the light-receiving element and performs an identification process. An optical axis of the illumination optical system and an optical axis of the light capturing optical system intersect each other. The illumination optical system is an imaging optical system that has a numerical aperture for the conveyance surface smaller than that of the light capturing optical system for the conveyance surface, or a collimator optical system that converts the light from the light source into parallel light.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: August 24, 2021
    Inventors: Yuki Yonetani, Shigeru Ichihara, Yasuhiro Sekine, Akira Yamamoto
  • Patent number: 11085824
    Abstract: The disclosure provides a super-resolution fast-scanning coherent Raman scattering imaging method. The method: using pump light and Stokes light; combining the pump light and the Stokes light to obtain combined light; expanding/collimating the combined light; the combined light after the expanding/collimating entering a galvanometer, passing through a group of a scanning lens/a tube lens and being focused on a back focal plane of a microobjective and incidenting into a biological sample, such that the biological sample is excited to emit anti-Stokes light; collecting the excited anti-Stokes light by a detector. This method is characterized by deflecting, at different angles, a single light spot focused on the microobjective through a diffractive optics group including DOE and a dispersive element, into a plurality of 1×N light spots to incident into the biological sample, such that the anti-Stokes light excited from smaller molecules and being condensed and filtered, is collected by the detector.
    Type: Grant
    Filed: September 7, 2020
    Date of Patent: August 10, 2021
    Inventors: Heping Zeng, Kangwen Yang, Xu Chen, Yue Shen, Shikai Zheng
  • Patent number: 11086123
    Abstract: Achromatically corrected Raman immersion probes minimize chromatic and/or spherical aberration through the use of an achromat, apochromat, refractive/diffractive optics as opposed to a single lens geometry. The improved end optics are adapted for use with a probe body carrying a laser excitation and/or collection beam associated with Raman analysis. The achromatically corrected optic to focus the beam onto or within a sample. The sample may be a gas, a liquid, or a partial liquid such as a slurry. The achromatically corrected optic may be an achromat comprising a lens doublet or an achromat comprising a lens triplet or more optical elements. In one preferred embodiment, the achromatically corrected optic may be an apochromatic optic. A disclosed system includes the achromatically corrected end optic and Raman probehead operative to send and receive counter-propagating laser excitation and collection beams.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: August 10, 2021
    Inventor: Harry Owen
  • Patent number: 11079332
    Abstract: A substance detection method and apparatus, and a detection device are provided. The method includes: obtaining spectral information and image information of a substance to be detected; performing image recognition according to the image information to obtain appearance state information of the substance to be detected; determining a sub-database matching the appearance state information in a preset spectral database according to the appearance state information, wherein the spectral database includes a plurality of sub-databases classified according to the appearance state of the substance; and matching the spectral information with the obtained spectral information in the sub-database to obtain a detection result of the substance to be detected.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: August 3, 2021
    Inventor: Lei Luo
  • Patent number: 11067512
    Abstract: A method is disclosed for providing enhanced quantitative analysis of materials by a dual-laser Raman probe wherein the wavelengths of the lasers used to illuminate a target object are selected in a manner to improve and enhance the quantitative analysis performance of the Raman signals.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: July 20, 2021
    Assignee: Innovative Photonic Solutions, Inc.
    Inventors: Greg W. Charache, Scott L. Rudder
  • Patent number: 11047772
    Abstract: A system for determining an amount of fungal particles in air in a building includes including: an air inlet connected to a filter for filtering particles having a size of 1-120 ?m; means for collecting fungal particles from the filtered particles and transferring the collected fungal particles to at least one sample cuvette; means for dry denaturation of the fungal particles; means for producing a voltage change of the dry denaturised fungal particles and means for detection of voltage changes caused by the dry denaturised fungal particles to obtain voltage change data; means for collecting a sample; means for wet denaturation of the fungal particles subsequent to the detection of voltage changes.
    Type: Grant
    Filed: November 12, 2017
    Date of Patent: June 29, 2021
    Assignee: Oy Fiseca Ltd.
    Inventor: Hannu Mäkelä
  • Patent number: 11041759
    Abstract: A method of performing Raman spectroscopy can include guiding a Raman pump beam with an optical fiber, where the Raman pump beam inducing fluorescence in the optical fiber. The beam and the fluorescence are coupled to a photonic integrated circuit (PIC) via the fiber. The beam is used to excite a sample in optical communication with the PIC via evanescent coupling and induces Raman scattering in the sample. The Raman scattering is collected via the PIC, and the Raman pump beam as well as the fluorescence is filtered out from the Raman scattering via the PIC.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: June 22, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Juejun Hu, Derek Kita, Jerome Michon
  • Patent number: 11041760
    Abstract: In multiplex CARS, a fingerprint region is a region where signals are densely concentrated. Information about the intensities and spatial distribution of these signals is important in cell analysis. However, there has been a problem in that the signal intensities are low. Accordingly, mechanisms 702 and 703 for adjusting the power branching ratio between light that enters a photonic crystal fiber 705 and pumping light; mechanisms 710 and 711 for adjusting the divergence/convergence state of the pumping light; and mechanisms 706 and 2101 for adjusting the divergence/convergence state of Stokes light are provided to enable adjustment for emphasizing a desired wavelength band.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: June 22, 2021
    Inventors: Manabu Shiozawa, Koichi Watanabe, Masataka Shirai