Abstract: Methods, apparatus, and systems provide improved identification of selected biohazard and/or biohazard signatures from complex in vivo or in vitro samples and include deep UV native fluorescence spectroscopic analysis for multiple locations of a sample wherein classification results for individual locations are combined and spatially correlated to provide a positive or negative conclusion of biohazard signature presence (e.g., for signatures for viruses, bacteria, and diseases including SARS-CoV-2 and its variants and COVID-19 and its variants). Improvements include one or more of reduced sample processing time (minutes to fractions of a minute), reduced sampling cost (dollars to fractions of a dollar), high conclusion reliability (rivaling real time RT-PCR). Some embodiments may incorporate a stage or scanning mirror system to provide movement of a sample relative to an excitation exposure location. Some embodiments may incorporate Raman or phosphorescence spectroscopic analysis as well as imaging systems.

Abstract: A Raman spectroscopy system is provided. The spectroscopy system includes an optical switch including a pump inlet, a return outlet, a plurality of pump outlets, and a plurality of return inlets. The spectroscopy system includes a plurality of radiation sources optically coupled to the pump inlet of the optical switch, and a detector optically coupled to the return outlet of the optical switch. The spectroscopy system further includes a plurality of probes, each probe optically connected to at least one of the plurality of pump outlets of the optical switch by at least one excitation fiber and optically coupled to one of the return inlets of the optical switch by at least one emission fiber.

Abstract: Quantum entanglement protection is disclosed. An entanglement checker receives, from a requestor, a request associated with a first qubit. In response to receiving the request, the entanglement checker accesses qubit entanglement information that identifies an entanglement status of the first qubit. The entanglement checker determines, based on the qubit entanglement information, the entanglement status of the first qubit, and sends a response to the requestor based on the entanglement status.

Abstract: A method is disclosed for providing enhanced quantitative analysis of materials by a dual-laser Raman probe wherein the wavelengths of the lasers used to illuminate a target object are selected in a manner to improve and enhance the quantitative analysis performance of the Raman signals.

Abstract: An integrated device for the detection of cancerous tissue including an optical fiber configured to receive at a first end modulated infrared light and to conduct the modulated infrared light from the first end to a second end; and a plasmonic metasurface, disposed on the second end of the optical fiber, configured to localize evanescent infrared light to sub-100 nanometer distances from the plasmonic metasurface of the optical fiber such that the localized evanescent infrared light penetrates only the membrane portion of a cell held against the second end, wherein the second end is configured to receive reflected light reflected from the membrane portion the cell, the reflected light including spectroscopic information indicative of whether the cell is noncancerous or cancerous.

Abstract: A Brillouin modality can be supplemented by an auxiliary modality, such as an optical imaging modality or a spectroscopy modality. In some embodiments, the auxiliary modality can be used to guide the Brillouin measurement to a desired region of interest, so that acquisition times for the Brillouin measurement can be reduced as compared to interrogating the entire sample. The auxiliary modality may have an acquisition speed faster than that of the Brillouin modality. In some embodiment, the auxiliary modality determines a composition of materials within a voxel in the sample interrogated by the Brillouin modality. Using the information provided by the auxiliary modality, the Brillouin signatures corresponding to the materials within the voxel can be unmixed, thereby providing a more accurate measurement of the sample.

Abstract: The present chip relates to a high-sensitive biosensor chip using a high extinction coefficient marker and a dielectric substrate, a measurement system, and a measurement method and, more specifically, to an ellipsometry-based high-sensitive biosensor technology or a measurement method using same, the technology amplifying an elliptically polarized signal by a marker having a high extinction coefficient and a dielectric substrate. The marker and the substrate used in the present chip measure a Brewster's angle shift or an elliptical polarization measurement angle with respect to an ultra-low concentration biological material (e.g. antibody or DNA).

Abstract: High quality factor electromagnetic metasurfaces are provided. The metasurface is configured to have in plane guided-mode resonances (e.g., corresponding to waveguide modes or the like). Coupling features are included in the metasurface that are configured to couple free-space radiation to the guided mode resonances. The resulting structures have a high-Q response to free-space radiation and can be used for various applications, such as beam splitting, beam steering, and beam focusing or defocusing.

Abstract: [Object] An optimal structure for spectroscopically analyzing a solid-phase or liquid-phase sample in a wavelength range of 1100 to 1200 nm by using supercontinuum light is provided. [Solution] Supercontinuum light generated by producing nonlinear effects in light from a pulse laser source 1 by a nonlinear element 2 and having a wavelength range including 1100 nm or greater and 1200 nm or less is subjected to pulse stretching by a pulse stretching element 3, and a solid-phase or a liquid-phase sample S is irradiated with the supercontinuum light. In the supercontinuum light, elapsed time and wavelength within one pulse are in a one-to-one correspondence, and computation means 5 computes a spectrum based on a change over time in an output from a light receiver 4 that has received light that has passed through the sample S.

Abstract: Systems and methods for holographic characterization of protein aggregates. Size and refractive index of individual aggregates in a solution can be determined. Information regarding morphology and porosity can be extracted from holographic data.

Abstract: A system for characterization of a brain tissue sample includes a laser having an excitation fiber and a probe coupled to the excitation fiber for irradiating the brain tissue sample with light at an excitation wavelength. The probe further includes a plurality of return fibers for receiving light scattered from the brain tissue sample, wherein each return fiber includes a microfilter that permits light to pass for a different, spaced apart marker region. A Raman spectrometer is in communication with the plurality of return fibers, and a processor is in communication with the Raman spectrometer for analyzing Raman spectra within the marker regions to identify a tissue type of the brain tissue sample as one of normal white matter brain tissue, normal grey matter brain tissue, brain tumor tissue, infiltrating tumor tissue, and necrotic tissue.

Abstract: A measuring device includes a measuring unit that measures the morphology of a convex portion, and a position fixing unit that includes an opening in which the convex portion is to be disposed and a fixing member which includes the opening at a center thereof and against which the periphery of the convex portion is to be pressed. The size of the opening of the position fixing unit is capable of being changed.

Abstract: A semiconductor light source configured for a spectrometer may include at least one multipixel chip, at least one color setting component disposed optically downstream of at least one of emission region, and a drive unit. The color setting component may be configured for altering a spectral emission behavior of assigned emission regions. The drive unit may be configured to operate a plurality of mutually independently drivable emission regions successively, such that during operation thereof at least three spectrally narrowband individual spectra are emitted successively by the plurality of mutually independently drivable emission regions together with the associated color setting component from which individual spectra a total spectrum emitted by the semiconductor light source is constituted.

Abstract: Systems and methods for holographic characterization of protein aggregates. Size and refractive index of individual aggregates in a solution can be determined. Information regarding morphology and porosity can be extracted from holographic data.

Abstract: An optical fiber laser induced breakdown spectroscopy detection device and a detection method are provided. The device comprises an optical fiber LIBS detector and a master control detection system. The master control detection system is installed in the master control room of a nuclear power plant, and the optical fiber LIBS detector is configured to perform detection in a pipeline. The master control detection system and the optical fiber LIBS detector are connected to each other via the transmission optical fiber and the control signal line. The remote on-line detection of the positioning and fixed point of the designated area of the inner wall of the main pipeline of the nuclear power plant can be detected on line in the master control room of the nuclear power plant.

Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.

Abstract: A standard reference material interface for a Raman probe includes a locator including a housing having a first end and a second end, the first end including an attachment portion configured to mate with an attachment portion of the Raman probe. The locator defines a central axis that intersects the first end and the second end. The standard reference material interface also includes a hermetically sealed standard reference material enclosure positioned at the second end of the housing and enclosing a standard reference material. An optical port is positioned within the housing between the Raman probe and the standard reference material relative to the central axis. The optical port includes a window.

Abstract: A stimulated Raman scattering microscope device is configured to irradiates a sample with a first optical pulse at a first repetition frequency, to irradiate the sample with a second optical pulse of an optical frequency different from an optical frequency of the first optical pulse at a second repetition frequency, and to detect optical pulses of the first repetition frequency that are included in detected light from the sample irradiated with the first optical pulse and the second optical pulse, as a detected optical pulse train. The second optical pulse is generated by dispersing predetermined optical pulses that include lights of a plurality of optical frequencies, regulating to output optical pulses of a predetermined number of different optical frequencies out of the dispersed optical pulses at the second repetition frequency, and coupling the regulated optical pulses.

Abstract: An image processing apparatus comprises a first obtaining unit configured to obtain a range of a transmittance of air that is designated in accordance with a user operation to a captured image, and a generation unit configured to generate a corrected image in which influence of a microparticle component in the air on the captured image is suppressed based on the range.

Abstract: A surface enhanced luminescence (SELS) sensor may include a substrate and nano fingers projecting from the substrate. Each of the nano fingers may include a polymer pillar having a sidewall and a top, a coating layer covering the sidewall and a metal cap supported by and in contact with the top of the pillar.

Abstract: A compact spectrometer includes an excitation light source configured to generate excitation light and arranged to illuminate a spot on a sample. A dispersive element includes at least one movable component and spatially separates output light emanating from the sample in response to the excitation light into a plurality of different wavelength bands. A moveable component of the dispersive element causes the plurality of different wavelength bands of the output light to be scanned across a detector. The detector includes at least one light sensor that senses the wavelength bands of the output light and generates an output electrical signal in response to the sensed output light.

Abstract: State-of-the-art portable Raman spectrometers use discrete free-space optical components that must be aligned well and that don't tolerate vibrations well. Conversely, the inventive spectrometers are made with monolithic photonic integration to fabricate some or all optical components on one or more planar substrates. Photonic integration enables dense integration of components, eliminates manual alignment and individual component assembly, and yields superior mechanical stability and resistance to shock or vibration. These features make inventive spectrometers especially suitable for use in high-performance portable or wearable sensors. They also yield significant performance advantages, including a large (e.g., 10,000-fold) increase in Raman scattering efficiency resulting from on-chip interaction of the tightly localized optical mode and the analyte and a large enhancement in spectral resolution and sensitivity resulting from the integration of an on-chip Fourier-transform spectrometer.

Abstract: A hard-apertureless spectrometer includes a housing, a collimator configured to collimate light provided from a soft-aperture of a target, a diffraction grating configured to spectroscopically analyze the collimated light, a condenser configured to condense the spectroscopically analyzed light, and a photodetector configured to receive the condensed light output from the condenser and detect a target characteristic.

Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.

Abstract: A method for making a plasmonic mushroom array includes: forming a plurality of metal nano-islands each having nanometer-range dimensions on a surface of a glass substrate; and subjecting to the glass substrate having the plurality of metal nano-islands formed thereon to reactive ion etching such that the plurality of metal nano-islands are converted to a plurality of mushroom-shaped structures each having a metal cap supported by a pillar made of a material of the glass substrate and each having dimensions smaller than the dimensions of the nano-islands, the plurality of mushroom-shaped structures being arranged in a substantially regular pattern with intervals smaller than average intervals between the nano-islands, thereby forming the plurality of nano-scale mushroom-shaped structures on the glass substrate that can exhibit localized surface plasmon resonance.

Abstract: A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer, and an optical system for coupling light from the optical source to a sample and for coupling light from the sample to the spectrometer and a further spectrometer. A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer and an optical system for coupling light from the optical source and a further optical source to a sample and for coupling light from the sample to the spectrometer. The optical system may be configured for coupling light from the optical source and the further optical source to the sample and for coupling light from the sample to the spectrometer and the further spectrometer. The Raman system may be portable and/or may be configured to be transported and/or carried and/or may be handheld.

Abstract: A chlorophyll fluorescence measuring system having at least one spectrometer coupled to a data logger. The data logger provides direct control of the spectrometer and includes on-board memory for storage of target and reference spectrum data obtained by the spectrometer. The data logger may be coupled to an external computer that receives and analyzes target and reference spectrum data to determine SIF using a spectral fitting algorithm. The system may include a spectrometer aiming system coupled to and controlled by the data logger. The system may also include one or more environmental sensors configured to measure environment variables. The environmental sensors may be coupled to the data logger for control and data storage. The environmental data may be communicated to the external computer for use in the spectral fitting algorithm. The data logger may be connected to a network for remote monitoring and control.

Abstract: A chip-based planar Raman spectroscopic measurement system is disclosed comprising at least a semiconductor laser as excitation light source, an output waveguide coupling and delivering laser light out of chip, a photo-detector monitoring the laser optical power, an input waveguide coupling signal light to chip, a planar spectrometer comprising Planar Waveguide Grating (PWG) and an array photo-detectors, and control electronics. In some embodiments the PWG is a fixed frequency Arrayed Waveguide Grating (AWG), the laser is frequency-tunable. In other embodiments, the laser has fixed frequency, the PWG or the AWG is frequency tunable. In either case, the frequency tunability will ensure the recapture of the spectral information missed due to the spectral characteristics of the planar waveguide grating such as the channel spacing of the AWG, resulting in high channel count and high-resolution Raman measurement of sufficient spectral range.

Abstract: This invention relates to a method and apparatus for the early detection and monitoring of colorectal cancer via the sampling of a patient's blood.

Abstract: A measuring device for time-resolved measurement of a measurement signal and for temporal separation of at least a first portion of the measurement signal, having a light source for emitting a pulsed excitation signal, at least one detector for receiving the measurement signal, the detector generating a detector signal from the measurement signal, at least one first forming unit for generating a first comparison signal, and at least one evaluation unit, the first comparison signal correlating with the excitation signal. At least one first logic function is provided which links at least the first comparison signal with a signal dependent on the detector signal so that the output of the logic function provides a measure of the intensity of the first portion of the measurement signal or of the detector signal. The output of the first logic function is connected to the at least one evaluation unit.

Abstract: A multi-analyte sensor system based on hollow core photonic bandgap fiber and Raman anti-Stokes spectroscopy. The system includes: i) an inlet to introduce an analyte sample into an analyzer chamber which analyzer includes; ii) a measurement system to derive the anti-Stokes spectral peaks and/or spectra of the sample; iii) a set of reference calibrants corresponding to the analytes of which the sample is primarily comprised; iv) a second inlet to introduce said calibrants into the analyzer chamber; v) a second measurement system to derive the anti-Stokes spectral peaks and/or spectra of the calibrants vi) an outlet through which the sample and calibrants are expelled from the analyzer chamber.

Abstract: The disclosure relates to a gravity gradiometer including a pair of magneto-optical traps for measuring a gravity gradient. A cold atom gravity gradiometer system includes comprising: first and second magneto-optical traps, each having a plurality of mirrored surfaces arranged to reflect an incident laser beam to trap respective first and second cold atom clouds separated from each other by a separation distance; an optical subsystem arranged to transmit a first laser beam in a first direction along a first longitudinal axis towards the first magneto-optical trap and a second laser beam in an opposite second direction along a second longitudinal axis towards the second magneto-optical trap, the second longitudinal axis being parallel to the first longitudinal axis.

Abstract: The invention relates to a test device (10) for analysing, more particularly for detecting, non-destructively, pressure and temperature, and preferably for detecting a gas concentration in foodstuffs (50.4) contained in packaging (50), the test device having: —a detection assembly (30) for detecting at least one parameter in a foodstuff (50.4) contained in packaging (50), the parameter being specific to a property to be examined of the foodstuff (50.4). According to the invention, the test device (10) is designed as a hand-held device.

Abstract: A particle counter includes: a multi-flow cell with flow passages arrayed in a first direction and having a section including a detection region, for detecting a particle, formed when the flow passage is irradiated with irradiation light; a light receiving optical system configured to receive emitted light generated from a particle contained in sample fluid flowing in the at least one flow passage and passing through the detection region; an optical axis moving unit configured to move an optical axis of the irradiation light and an optical axis of the emitted light in the first direction; and a counter configured to count the particle for each particle size based on an intensity of the emitted light.

Abstract: Systems and methods are described to provide speciation of silicon species present in a remote sample for analysis. A method embodiment includes, but is not limited to, receiving a fluid sample containing inorganic silicon in the presence of bound silicon from a remote sampling system via a fluid transfer line; transferring the fluid sample to an inline chromatographic separation system; separating the inorganic silicon from the bound silicon via the inline chromatographic separation system; transferring the separated inorganic silicon and bound silicon to a silicon detector in fluid communication with the inline chromatographic separation system; and determining an amount of one or more of the inorganic silicon or the bound silicon in the fluid sample via the silicon detector.

Abstract: A surface enhanced Raman spectroscopy (SERS) device, comprises a non-electrically conductive substrate, at least two microelectrodes disposed on the substrate in a spaced relationship such that a detection site is formed along edges and/or between opposing edges of the microelectrodes, and a nanoparticle structure comprising a plurality of metallic nanoparticles disposed in the detection site. Assembly of the nanoparticle structure may be directed by an electric field between the at least two microelectrodes. The SERS device is inexpensive, robust, portable, and reusable. Also described herein are methods for using and preparing the SERS devices with simple, rapid, and inexpensive fabrication techniques.

Abstract: A method for the determination of antibiotic susceptibility through stimulated Raman scattering microscopy is disclosed. The method utilizes a imaging apparatus adapted to collect a laser signal through a sample having a bacteria for imaging the metabolism of the sample. The sample can be manipulated with an antibiotic for imaging to determine the susceptibility of a bacteria to the provided antibiotic.

Abstract: A preform (10) for an antiresonant hollow core optical fibre comprises an outer jacket tube (12) having an inner surface and a central longitudinal axis (24); a plurality of antiresonant cladding tubes (14) spaced apart at predefined peripheral locations around the inner surface of the outer jacket tube (12), each antiresonant cladding tube (14) in contact with the inner surface such that a central longitudinal axis (26) of each antiresonant cladding tube (14) is at a first radial distance from the central longitudinal axis (24) of the outer jacket tube (12); and a plurality of spacing elements (22) disposed alternately with the antiresonant cladding tubes (14) and each in contact with an outer surface of each of two adjacent antiresonant cladding tubes (14) at one or more contact points (28), the contact points (28) at a second radial distance from the central longitudinal axis (24) of the outer jacket tube (12), the second radial distance being greater than the first radial distance.

Abstract: A method for automated, in-line measurement of a differentiated surface cleanliness, in terms of carbon, of a continuously-moving metal sheet or strip, having a level of surface carbon pollution lower than 100 mg/m2, includes: generating a radiation beam using a source; focusing the radiation beam using a focusing device such that an energy density deposited on the metal strip or sheet is sufficient to create a plasma and generate CN radicals in the plasma if carbon and nitrogen are present; creating a nitrogen atmosphere around the plasma using a sweeping system with a flow rate that prevents any presence of oxygen from air in the plasma; analyzing light emitted by the plasma using an optical collection device, and redirecting the light toward a spectrometer or device for separating wavelengths of the emitted light; measuring an intensity of an intense vibration line of the CN radical.

Abstract: Measurement device for the detection and/or characterization of fluid-borne particles featuring a laser positioned for emitting pulses of laser light polarized in a first direction, in a measurement volume of a fluid flow path, each pulse having a pulse duration, and a means for directing the laser pulses polarized in a second different direction of polarization in the measurement volume. An optical spectrometer captures fluorescent light emitted by individual fluid-borne particles and measures the intensity of at least one wavelength at a sampling rate of at least three samples per pulse. The means for directing are configured to direct laser light polarized in the second direction each time a pulse of laser light crosses the measurement volume, the time delay between the two crossings being longer than the pulse duration and shorter than a travel time of the fluid in the measurement volume.

Abstract: A method of measuring a polarization response of a sample (1), in particular a biological sample, comprises the steps of generating a sequence of excitation waves (2), irradiating the sample (1) with the sequence of excitation waves (2), including an interaction of the excitation waves (2) with the sample (1), so that a sequence of sample waves (3) is generated each including a superposition of a sample main pulse and a sample global molecular fingerprint (GMF) wave (EGMF(sample)(t)), irradiating a reference sample (1A) with the sequence of excitation waves (2), including an interaction of the excitation waves (2) with the reference sample (1A), so that a sequence of reference waves (3A) is generated each including a superposition of a reference main pulse and a reference GMF wave (EGMF(ref)(t)), optically separating a difference of the sample waves (3) and reference waves (3A) from GMF wave contributions which are common to both of the sample waves (3) and reference waves (3A) in space and/or time, and detec

Abstract: A surface enhanced luminescence analyte interrogation stage may include a substrate and an array of pillars projecting from the substrate. Each of the pillars may include a polymeric post formed from a first material and a cap on the polymeric post. The cap has a plasmonic surface and is formed from a second material different than the first. A sacrificial coating covers the cap of each of the pillars.

Abstract: An apparatus for sorting cells includes a measurement volume that contains a cell to be measured, a light source that provides light to cause an emission by a fluorescent label attached to the cell, and an optic device that directs the light through the measurement volume. The apparatus flows the cells through the measurement volume such that as the cell flows through the measurement volume, it interacts with the light, resulting in a change in light originating from the measurement volume, the change in light is a fluorescence emission. Another optic device directs a portion of the light originating from the measurement volume to a detector, which detects the portion of the light. A processor operably coupled to the detector generates an estimate of DNA quantity in the cell based on the change in light originating from the measurement volume, and determines a characteristic of the cell from the estimate.

Abstract: A method of investigating a sample (1) having an absorption within an infrared spectral range of interest, comprises the steps of creating measuring light (2) with a light source device (10), wherein the measuring light (2) includes wavelengths covering the infrared spectral range, directing the measuring light (2) through the sample (1) to a detector device (20) with a plurality of detector units (21), each of which comprising an infrared sensitive sensor section (22) and an associated metamaterial resonator section (23) having a specific spectral resonance line (3), wherein the spectral resonance lines (3) of the resonator sections (23) have different frequencies within the infrared spectral range, wherein the measuring light (2) is transmitted through the sample (1) to the resonator sections (23) and subsequently sensed by the sensor sections (22), wherein an output of each of the sensor sections (22) depends on the absorption of the sample (1) at the frequency of the spectral resonance line (3) of the ass

Abstract: A measurement system of photoluminescence properties of a sample, comprises a radiation source module configured to generate a first radiation, an excitation optical path coupled to the radiation source module, a support structured to support a sample to be optically coupled to excitation optical path and adapted to provide a photoluminescence radiation, and collection path coupled to the sample and configured to propagate the photoluminescence radiation. The system also includes an analysis device configured to receive the photoluminescence radiation and provide data/information on photoluminescence properties of sample. At least one path between the excitation path and the collection path comprises a respective adjustable birefringent common-path interferometer module configured to produce first and second radiations adapted to interfere with each other.

Abstract: A method for identifying minerals and other materials illuminates a mineral with monochromatic light for an illumination duration and a true Raman spectrum is determined. The true Raman spectrum data is compared to reference spectrums to identify the mineral or material by calculating an identification score for each reference Raman spectrum relative to the Raman spectrum data of the unknown material using a formula that includes both a coincident-peak term and a missing-peak-penalty term.

Abstract: Standoff ultra-compact micro-Raman sensors configured to receive Raman scattering from a substance are disclosed. A laser device may be configured to transmit a laser at a first wavelength. The laser may be expanded to a predetermined size, focused through a lens, and made incident on an unknown substance. A filter may reflect the laser and Rayleigh scattering from the substance, but may permit Raman scattering and laser-induced fluorescence from the substance. One or more lenses and/or filters may receive and pass the Raman scattering and/or laser-induced fluorescence to a light sensor. The received Raman scattering and/or laser-induced fluorescence may be compared to known fingerprints of substances to determine an identity of the substance. The wavelength of the laser, the width of the laser, and other parameters may be varied based on the distance between the standoff ultra-compact micro-Raman sensor and the substance.

Abstract: A method for measuring one or more quantities characterizing a composition of a medium includes causing a first non-uniform spatially varying optical signal to impinge on a portion of the medium, processing a second optical signal emitted from the medium in response to the first optical signal including determining characteristics of a spatial variation of the second optical signal, and determining the one or more quantities characterizing the composition of the medium based on the characteristics of the spatial variation of the second optical signal.

Abstract: The present invention relates to devices and methods for detecting the amount (degree, extent) of material coating a medical device or substrate, in particular the present invention relates to devices and methods for detecting the amount of vaccine material coating a microarray patch.

Abstract: An apparatus comprises: a photonic cavity; a substrate comprising a waveguide layer, wherein the waveguide layer comprises waveguides configured to direct light towards the photonic cavity; and a wafer comprising: a top side, and a nanowire array affixed to the top side. A method of performing a surface-enhanced Raman scattering (SERS) analysis, the method comprises: directing, using a waveguide layer of a SERS device, an incident light towards a photonic cavity of the SERS device; permitting, using the photonic cavity, a fluid to flow freely into and out of the SERS device; causing, within the photonic cavity, an interaction among the incident light, the fluid, and a nanowire array of the SERS device to create scattered light; converting the scattered light into an electrical signal; and analyzing the electrical signal to determine whether a contaminant exists in the fluid.