With Raman Type Light Scattering Patents (Class 356/301)
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Patent number: 11150191Abstract: An apparatus comprises: a photonic cavity; a substrate comprising a waveguide layer, wherein the waveguide layer comprises waveguides configured to direct light towards the photonic cavity; and a wafer comprising: a top side, and a nanowire array affixed to the top side. A method of performing a surface-enhanced Raman scattering (SERS) analysis, the method comprises: directing, using a waveguide layer of a SERS device, an incident light towards a photonic cavity of the SERS device; permitting, using the photonic cavity, a fluid to flow freely into and out of the SERS device; causing, within the photonic cavity, an interaction among the incident light, the fluid, and a nanowire array of the SERS device to create scattered light; converting the scattered light into an electrical signal; and analyzing the electrical signal to determine whether a contaminant exists in the fluid.Type: GrantFiled: February 28, 2020Date of Patent: October 19, 2021Assignee: The Board of Regents of the University of OklahomaInventors: Binbin Weng, Mark A. Nanny, Joseph M. Suflita, Rouzbeh Ghanbarnezhad Moghanloo
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Patent number: 11145411Abstract: A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.Type: GrantFiled: November 6, 2013Date of Patent: October 12, 2021Assignee: CHEMIMAGE CORPORATIONInventors: Patrick Treado, Shona Stewart, Heather Kirschner, Ryan Priore, Alan Wilson
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Patent number: 11137245Abstract: Provided is a Raman spectroscopy method for simultaneously measuring a temperature and a thermal stress of a two-dimensional film material in situ. The method includes: providing the two-dimensional film material including a suspended part and a supported part and measuring Raman signals of the suspended part and the supported part; establishing equations of a Raman shift with temperature and a Raman shift with thermal stress for each of the suspended part and the supported part, and solving simultaneous equations to obtain coefficients with temperature and thermal stress; and scanning a characteristic Raman spectrum field of the two-dimensional film material and obtaining a temperature distribution and a thermal stress distribution of the two-dimensional film material according to the characteristic Raman spectrum field in combination of the coefficients of the Raman shift with temperature and the Raman shift with thermal stress.Type: GrantFiled: May 19, 2020Date of Patent: October 5, 2021Assignee: TSINGHUA UNIVERSITYInventors: Xing Zhang, Haidong Wang, Hexin Liu
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Patent number: 11137375Abstract: Systems and methods for focusing a light pulse within a focus area using nonlinear photoacoustic wavefront shaping (PAWS) are disclosed herein. The method includes modulating a spatial phase pattern of a light pulse's waveform based on a Grueneisen-relaxation photoacoustic (GR-PA) feedback signal. In addition, systems and methods for performing Grueneisen-relaxation photoacoustic microscopy (GR-PAM) are disclosed herein that include analyzing photoacoustic signals resulting from illumination of a focus region by two closely spaced light pulses. A method of obtaining an absorption coefficient of a sample using Grueneisen-relaxation photoacoustic microscopy (GR-PAM) is also disclosed.Type: GrantFiled: November 19, 2014Date of Patent: October 5, 2021Assignee: California Institute of TechnologyInventors: Lihong V. Wang, Lidai Wang, Chi Zhang, Puxiang Lai, Jian Wei Tay
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Patent number: 11125692Abstract: In a method of determining the type of each cell contained in a sample, one Raman spectrum is acquired from one undetermined cell, a plurality of degrees of matching of a Raman spectrum of the undetermined cell with respect to spectra of a plurality of principal components obtained by principal component analysis of a plurality of Raman spectra that are obtained one by one from each of a plurality of known types of cells are calculated, and a type of the undetermined cell is determined by classifying the plurality of degrees of matching based on a result obtained by classifying a plurality of principal component scores corresponding to each of the plurality of known types of cells obtained by the principal component analysis depending on the type of cells by a learning model using supervised learning.Type: GrantFiled: December 12, 2018Date of Patent: September 21, 2021Assignee: HORIBA, LTD.Inventors: Yoshito Okuno, Daisuke Irikura, Sakiko Akaji, Shiro Miyake
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Patent number: 11125621Abstract: Embodiments of a system and a method for polarimetry using static geometric manipulation of the state of polarization are disclosed. According to one embodiment, a spectropolarimeter comprises a retarder having a geometrically changing fast axis. The fast axis changes along a polarimetric dimension. The spectropolarimeter has a polarization analyzer and a spectrographic optical platform. The spectrographic optical platform has a slit in a spatial dimension same as the polarimetric dimension of the retarder; a collimator; a dispersing element for dispersing spectral components of light received from the collimator along a spectral dimension that is perpendicular to the spatial dimension of the slit; a focusing optic; and a two-dimensional detector array. Using a quarter wave retarder full Stokes polarimetry can be provided though a half wave retarder can also be used.Type: GrantFiled: November 8, 2019Date of Patent: September 21, 2021Assignee: SETI INSTITUTEInventor: William B. Sparks
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Patent number: 11118974Abstract: A spectroscopic device is provided. The spectroscopic device includes a plurality of design groups on a substrate. Each design group includes a plurality of collapsed groups separated by bare regions of substrate, wherein the edges of each design group is configured to enhance the pinning of a solvent drying line at the edge of the design group. Each collapsed group comprises at least 2 flexible columnar structures, and each flexible columnar structure comprises a metal cap.Type: GrantFiled: July 19, 2017Date of Patent: September 14, 2021Assignee: Hewlett-Packard Development Company, L.P.Inventors: Steven Barcelo, Anita Rogacs
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Patent number: 11119044Abstract: The method for determining the presence of a molecule having a Raman resonance generally comprises illuminating a sample with a first radiation beam, the first radiation beam having a first excitation wavelength being tuned to a Raman resonance of the molecule; receiving a first return signal from the sample following illumination of the sample with the first radiation beam; measuring a first intensity of the first return signal using an intensity detector; illuminating the sample with a second radiation beam, the second radiation beam lacking the first excitation wavelength and having a second excitation wavelength being different from the first excitation wavelength; receiving a second return signal from the sample following illumination of the sample with the second radiation beam; measuring a second intensity of the second return signal using an intensity detector; and determining the presence of the molecule in the sample based on the first and second intensities.Type: GrantFiled: August 18, 2017Date of Patent: September 14, 2021Assignee: INSTITUT NATIONAL D'OPTIQUEInventor: François Babin
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Patent number: 11119045Abstract: An apparatus for analyzing microbiome according to an embodiment of the inventive concept includes a light source unit configured to excite first light, a sample unit on which a sample to which the first light is incident is disposed, and a data analysis unit configured to receive second light emitted from the sample unit and analyze microbiome in the sample from the second light. Here, the sample unit includes a conductive polymer structure that surrounds the sample.Type: GrantFiled: November 13, 2019Date of Patent: September 14, 2021Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTEInventors: Won Kyoung Lee, Bong Kyu Kim, Soo Jun Park, Chul Huh
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Patent number: 11112331Abstract: A monitoring system is disclosed herein that is configured to utilize a distributed sensing system to monitor both a cable and cable accessories included within a cable circuit. In various embodiments, the monitoring system may include a distributed sensing system and one or more cable accessory wrap assemblies. The distributed sensing system may include a distributed sensing fiber following (or integrated into) the cable and connected to a cable accessory wrap assembly for each of the one or more cable accessories in-line with cable. In various embodiments, each cable accessory wrap assembly may comprise a cable wrap embedded with a distributed sensing fiber. The distributing sensing fiber of a cable accessory wrap assembly may be configured to provide measurements to distributed sensing system indicating that an anomaly event occurred at a given cable accessory.Type: GrantFiled: March 5, 2021Date of Patent: September 7, 2021Assignee: Marmon Utility LLCInventors: Rick Williamson, Michael P. Norton, Sergio Arellano
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Patent number: 11109781Abstract: Various embodiments of the invention provide systems and methods for low-cost, low-power Array Waveguide Grating (AWG)-based miniaturized Raman spectroscopy for use in non-invasive glucose monitoring systems, such as in wearable devices that require no replenishment of chemicals or enzymes. The AWG may be manufactured using VLSI processing technology, which significantly reduces manufacturing cost and replaces holographic grating as the dispersive component of light. In embodiments, the AWG is integrated with a number of PIN photodiode detectors on a substrate to further reduce cost and signal loss. In embodiments, a prism-coupling method eliminates alignment problems associated with traditional approaches that utilize fiber-coupling methods.Type: GrantFiled: February 6, 2018Date of Patent: September 7, 2021Inventors: Sheng Yang, Yen-Chun Yeh, Dominik Schmidt
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Patent number: 11105682Abstract: A system and method for imaging a sample using Raman spectrometry. Optical fibers having opposite first ends and second ends are arranged with the first ends and second ends in respective two-dimensional arrays. The two-dimensional arrays maintain relative positions of the optical fibers to one another from the first ends to the second ends in a way that the first end of each optical fibers of the bundle can simultaneously collect a corresponding Raman signal portion scattered from specific spatial coordinates of the area of the sample. The so-collected Raman signal portions are propagated towards the corresponding second end, from which are outputted and detected simultaneously using an array of detectors.Type: GrantFiled: September 14, 2018Date of Patent: August 31, 2021Inventors: Frederic Leblond, Karl St-Arnaud, Francois Daoust
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Patent number: 11099073Abstract: An identification apparatus identifies the kind of an object to be conveyed by a conveyor and includes an illumination optical system illuminating the object with light from a light source, a light capturing optical system capturing Raman-scattered light from the object, a spectral element dispersing the Raman-scattered light, a light-receiving element receiving the Raman-scattered light dispersed by the spectral element, and a data-processing unit acquiring spectral data of the Raman-scattered light from the light-receiving element and performs an identification process. An optical axis of the illumination optical system and an optical axis of the light capturing optical system intersect each other. The illumination optical system is an imaging optical system that has a numerical aperture for the conveyance surface smaller than that of the light capturing optical system for the conveyance surface, or a collimator optical system that converts the light from the light source into parallel light.Type: GrantFiled: June 3, 2020Date of Patent: August 24, 2021Assignee: CANON KABUSHIKI KAISHAInventors: Yuki Yonetani, Shigeru Ichihara, Yasuhiro Sekine, Akira Yamamoto
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Patent number: 11085824Abstract: The disclosure provides a super-resolution fast-scanning coherent Raman scattering imaging method. The method: using pump light and Stokes light; combining the pump light and the Stokes light to obtain combined light; expanding/collimating the combined light; the combined light after the expanding/collimating entering a galvanometer, passing through a group of a scanning lens/a tube lens and being focused on a back focal plane of a microobjective and incidenting into a biological sample, such that the biological sample is excited to emit anti-Stokes light; collecting the excited anti-Stokes light by a detector. This method is characterized by deflecting, at different angles, a single light spot focused on the microobjective through a diffractive optics group including DOE and a dispersive element, into a plurality of 1×N light spots to incident into the biological sample, such that the anti-Stokes light excited from smaller molecules and being condensed and filtered, is collected by the detector.Type: GrantFiled: September 7, 2020Date of Patent: August 10, 2021Assignees: CHONGQING INSTITUTE OF EAST CHINA NORMAL UNIVERSITY, EAST CHINA NORMAL UNIVERSITY, UNIVERSITY OF SHANGHAI FOR SCIENCE AND TECHNOLOGYInventors: Heping Zeng, Kangwen Yang, Xu Chen, Yue Shen, Shikai Zheng
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Patent number: 11086123Abstract: Achromatically corrected Raman immersion probes minimize chromatic and/or spherical aberration through the use of an achromat, apochromat, refractive/diffractive optics as opposed to a single lens geometry. The improved end optics are adapted for use with a probe body carrying a laser excitation and/or collection beam associated with Raman analysis. The achromatically corrected optic to focus the beam onto or within a sample. The sample may be a gas, a liquid, or a partial liquid such as a slurry. The achromatically corrected optic may be an achromat comprising a lens doublet or an achromat comprising a lens triplet or more optical elements. In one preferred embodiment, the achromatically corrected optic may be an apochromatic optic. A disclosed system includes the achromatically corrected end optic and Raman probehead operative to send and receive counter-propagating laser excitation and collection beams.Type: GrantFiled: February 4, 2020Date of Patent: August 10, 2021Inventor: Harry Owen
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Patent number: 11079332Abstract: A substance detection method and apparatus, and a detection device are provided. The method includes: obtaining spectral information and image information of a substance to be detected; performing image recognition according to the image information to obtain appearance state information of the substance to be detected; determining a sub-database matching the appearance state information in a preset spectral database according to the appearance state information, wherein the spectral database includes a plurality of sub-databases classified according to the appearance state of the substance; and matching the spectral information with the obtained spectral information in the sub-database to obtain a detection result of the substance to be detected.Type: GrantFiled: January 24, 2019Date of Patent: August 3, 2021Assignee: CLOUDMINDS (SHENZHEN) ROBOTICS SYSTEMS CO., LTD.Inventor: Lei Luo
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Patent number: 11067512Abstract: A method is disclosed for providing enhanced quantitative analysis of materials by a dual-laser Raman probe wherein the wavelengths of the lasers used to illuminate a target object are selected in a manner to improve and enhance the quantitative analysis performance of the Raman signals.Type: GrantFiled: March 26, 2020Date of Patent: July 20, 2021Assignee: Innovative Photonic Solutions, Inc.Inventors: Greg W. Charache, Scott L. Rudder
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Patent number: 11047772Abstract: A system for determining an amount of fungal particles in air in a building includes including: an air inlet connected to a filter for filtering particles having a size of 1-120 ?m; means for collecting fungal particles from the filtered particles and transferring the collected fungal particles to at least one sample cuvette; means for dry denaturation of the fungal particles; means for producing a voltage change of the dry denaturised fungal particles and means for detection of voltage changes caused by the dry denaturised fungal particles to obtain voltage change data; means for collecting a sample; means for wet denaturation of the fungal particles subsequent to the detection of voltage changes.Type: GrantFiled: November 12, 2017Date of Patent: June 29, 2021Assignee: Oy Fiseca Ltd.Inventor: Hannu Mäkelä
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Patent number: 11043647Abstract: The present disclosure relates to a quantum dot film including a self-assembled block copolymer, and a quantum dot bonded to the block copolymer, wherein the film has pores with an average diameter of 100-3000 nm inside.Type: GrantFiled: December 7, 2018Date of Patent: June 22, 2021Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Yeon Sik Jung, Duk Young Jeon, Geon Yeong Kim, Jin Young Choi, Chul Hee Lee, Hun Hee Lim
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Patent number: 11041759Abstract: A method of performing Raman spectroscopy can include guiding a Raman pump beam with an optical fiber, where the Raman pump beam inducing fluorescence in the optical fiber. The beam and the fluorescence are coupled to a photonic integrated circuit (PIC) via the fiber. The beam is used to excite a sample in optical communication with the PIC via evanescent coupling and induces Raman scattering in the sample. The Raman scattering is collected via the PIC, and the Raman pump beam as well as the fluorescence is filtered out from the Raman scattering via the PIC.Type: GrantFiled: June 28, 2019Date of Patent: June 22, 2021Assignee: Massachusetts Institute of TechnologyInventors: Juejun Hu, Derek Kita, Jerome Michon
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Patent number: 11041760Abstract: In multiplex CARS, a fingerprint region is a region where signals are densely concentrated. Information about the intensities and spatial distribution of these signals is important in cell analysis. However, there has been a problem in that the signal intensities are low. Accordingly, mechanisms 702 and 703 for adjusting the power branching ratio between light that enters a photonic crystal fiber 705 and pumping light; mechanisms 710 and 711 for adjusting the divergence/convergence state of the pumping light; and mechanisms 706 and 2101 for adjusting the divergence/convergence state of Stokes light are provided to enable adjustment for emphasizing a desired wavelength band.Type: GrantFiled: March 11, 2015Date of Patent: June 22, 2021Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Manabu Shiozawa, Koichi Watanabe, Masataka Shirai
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Patent number: 11038011Abstract: Methods of fabricating a structure for a metal-insulator-metal (MIM) capacitor. Conductive nanofibers are formed on a surface of a conductor layer. Each conductive nanofiber is terminated by an enlarged tip portion opposite the surface of the conductor layer. The enlarged tip portion is removed from each conductive nanofiber. The MIM capacitor may include the conductive nanofibers as portions of an electrode.Type: GrantFiled: October 29, 2019Date of Patent: June 15, 2021Assignee: GLOBALFOUNDRIES U.S. INC.Inventors: Lili Cheng, Robert J. Fox, III, Luke England
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Patent number: 11029398Abstract: Light detection and ranging (LiDAR) systems and methods of operating the LiDAR systems are provided. The LiDAR system includes a light emitter configured to emit first lights of different wavelengths in a vertical direction and at different scanning angles with respect to a horizontal axis, a lens configured to converge second lights that are reflected from objects on which the first lights are emitted, and a light filter comprising an active-type device configured to adjust a transmission central wavelength of the active-type device to the different wavelengths of the first lights that are emitted from the light emitter. The LiDAR system further includes a controller configured to control an operation of the light emitter and the light filter, and a detector configured to detect light from the light emitter, and obtain information about the objects.Type: GrantFiled: February 5, 2018Date of Patent: June 8, 2021Assignee: SAMSUNG ELECTRONICS CO., LTD.Inventors: Inoh Hwang, Dongjae Shin, Jungwoo Kim, Tatsuhiro Otsuka, Heesun Yoon
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Patent number: 11029250Abstract: A method for determining thermal maturity of a formation sample. The method includes: cleaning the formation sample to remove residues of drilling fluid and reservoir fluid to obtain a cleaned sample; performing Raman spectroscopic measurements on the cleaned sample to obtain a Raman spectrum for the cleaned sample; fitting at least a G (graphite) peak and a D1 (defect) peak to the Raman spectrum to obtain Raman shift values for the G peak and the D1 peak and a Raman band separation (RBS) value; using the RBS to generate a vitrinite reflection equivalent (VRe) value using a relationship correlating RBS to VRe; and displaying the VRe as an indicator of formation sample maturity for a depth in the formation from which the cleaned sample was obtained.Type: GrantFiled: February 21, 2018Date of Patent: June 8, 2021Assignee: Schlumberger Technology CorporationInventors: Bastian Sauerer, Wael Abdallah
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Patent number: 11026604Abstract: Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.Type: GrantFiled: July 13, 2018Date of Patent: June 8, 2021Assignee: Cercacor Laboratories, Inc.Inventors: Jesse Chen, Sean Merritt, Cristiano Dalvi, Ferdyan Lesmana, Hung The Vo, Kevin Hughes Pauley, Jeroen Poeze, Ruiqi Long, Stephen L. Monfre
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Patent number: 11004006Abstract: Methods and systems for personalized trust recommendation based on a dynamic trust model. In an example embodiment, a trust framework can be derived from a set of use-case specific factors. Invasive data and non-invasive data can be collected from a user (or a group of users) based on activity data and profile data associated with the user. A dynamic trust profile can be created (or learned) based on the invasive data and the non-invasive data collected from the user. A recommended level of trustworthiness can be then provided to the user respect to a particular situation and/or entity (e.g. other users) within the trust framework based on the dynamic trust profile of the user and which is personalized for the user.Type: GrantFiled: August 30, 2018Date of Patent: May 11, 2021Assignee: Conduent Business Services, LLCInventors: Jayati Bandyopadhyay, Nupur Labh, Simarjot Kaur, Arun Rajkumar, Saurabh Srivastava, Saurav Bhattacharya, Neha Singh
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Patent number: 11002681Abstract: The invention provides a method for rapid detection of a specific bacterial species. The method includes preparing a sample, irradiating the prepared sample with an electromagnetic radiation of specific wavelength, capturing the electromagnetic radiation scattered by the sample to obtain a Raman spectra and analyzing the Raman spectra to obtain a unique biochemical signature. The unique biochemical signature identifies a single bacterium within the sample. The method also provides for rapid detection of a group of bacterial species within the sample. The method takes about 1 minute to about 1 hour for the detection of specific bacterial species.Type: GrantFiled: January 27, 2016Date of Patent: May 11, 2021Assignee: INDIAN INSTITUTE OF SCIENCEInventors: Siva Umapathy, Deepak Kumar Saini, Srividya Kumar
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Patent number: 10983001Abstract: A Raman probe includes: a light source configured to emit light onto an object; a light collector configured to collect Raman-scattered light from the object by reflecting the Raman-scattered light, the light collector including a light incident port, a light emitting port, and a reflective surface including a light incident port portion and a light emitting port portion, a slope of the light incident port portion with respect to an optical axis of the light collector being smaller than a slope of the light emitting port portion with respect to the optical axis; a condenser lens configured to collect the Raman-scattered light collected by the light collector; and a photodetector configured to detect the Raman-scattered light collected by the condenser lens.Type: GrantFiled: July 30, 2019Date of Patent: April 20, 2021Assignee: SAMSUNG ELECTRONICS CO., LTD.Inventor: Ho Jun Chang
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Patent number: 10974971Abstract: The disclosed is provided with a composite material device, comprising a substrate, a plurality of pores provided on the substrate, and a plurality of metal particles adhered onto inner walls of the pores, the metal particles having a particle size of from 1 to 200 nm, wherein the plurality of metal particles have at least x different particle sizes d. The composite material device of the present discloser has a high light absorption rate and a broad light absorption wavelength range.Type: GrantFiled: November 11, 2016Date of Patent: April 13, 2021Assignee: NANJING UNIVERSITYInventors: Jia Zhu, Lin Zhou, Yingling Tan
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Patent number: 10969338Abstract: A method and system for interrogating a target for one or more chemical species of interest using Raman microscopy and spectroscopy. A feature includes the ability to precisely electro-mechanically move and orient a Raman microscope relative to the target with multiple degrees of freedom of movement, including targets with 3-D form factors. This promotes effective detection of minute quantities of chemical species of interest. It also allows effective detection of minute quantities whether the target is static or moving. The method and system can include enhancements. Examples include alternative imaging spectrometers, alternative Raman microscope optical set-ups, and alternative focusing techniques. Others include control of the excitation energy and user controls and options to allow highly adjustable, flexible, and effective detection for a variety of detection applications.Type: GrantFiled: February 12, 2020Date of Patent: April 6, 2021Assignee: Alakai Defense Systems, Inc.Inventors: Darius Vunck, Robert Douglas Waterbury, Timothy Molner, Ed Dottery, Hunter Hardy, Ryan Robins, Thuyan Conghuyentonnu
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Patent number: 10955352Abstract: A method for assessing a state of a living cell using surface enhanced Raman spectroscopy (SERS) is provided. The method may include modifying one or more living eel Is with an alkyne-containing compound to form one or more modified living cells, mixing the one or more modified living cells with a SERS-active material to form a mixture, injecting the mixture into a conduit defined by an inner wall of a hollow core photonic crystal fiber, and detecting a surface enhanced Raman signal from the mixture in the conduit. In preferred embodiments, the alkyne containing compound is linoleamide alkyne (LLA) for the detection of lipid peroxidation or 4-(dihydroxyborophenyl) acetylene (DBA) for the detection of sialic acid expression in cells, both using gold nanoparticles as the SERS-active material.Type: GrantFiled: January 12, 2017Date of Patent: March 23, 2021Assignee: Agency for Science, Technology and ResearchInventors: Tianxun Gong, Malini Olivo
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Patent number: 10950443Abstract: A method for forming patterns includes forming an etch barrier stack where a first sacrificial material, first mask lines, a second sacrificial material and second mask lines intersecting with the first mask lines are sequentially disposed on an etch target material, etching the second an first sacrificial materials using the second and first mask lines as etch masks, to form island-shaped sacrificial openings isolated from one another in the first sacrificial material, forming island-shaped sacrificial pillars to fill the island-shaped sacrificial openings, etching the first mask lines to form island-shaped masks at intersections between the first mask lines and the second mask lines, and etching the first sacrificial material using the island-shaped masks and the island-shaped sacrificial pillars as etch masks, to form a sacrificial barrier including island-shaped openings isolated from one another to expose the etch target material.Type: GrantFiled: October 25, 2019Date of Patent: March 16, 2021Assignee: SK hynix Inc.Inventors: Han-Chul Lee, Won-Hyuck Choi
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Patent number: 10947141Abstract: Methods and systems for controlling a denitrification reaction in a biological nitrogen removal reactor including denitrifying bacteria to favor denitratation of nitrate to nitrite and limit denitritation of nitrite to nitrogen gas are disclosed. pH, dissolved oxygen levels, solids retention time, and chemical oxygen demand to nitrogen ratio are controlled to favor this reaction. Wastewater or contaminated groundwater including concentrations of ammonium and nitrate are continuously fed to the biological nitrogen removal reactor along with a source of carbon and electrons as an influent, which is treated to form a nitrite effluent. The nitrite effluent may then be fed to an anammox reactor including anammox bacteria for production of nitrogen gas. The system may be operated under substantially anoxic conditions, which provides significant cost savings without sacrificing efficiency or productivity compared to traditional wastewater treatment systems and processes.Type: GrantFiled: June 22, 2017Date of Patent: March 16, 2021Assignee: The Trustees of Columbia University in the City of New YorkInventors: Kartik Chandran, Luke Plante
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Patent number: 10942123Abstract: We disclose methods and apparatus for measuring pH in a sub-surface volume of a diffusely scattering sample. Probe light is directed to an entry region on the sample surface, and collected from a collection region on the sample surface following diffuse scattering within the sample. The collection region is spatially offset from the entry region, so that when one or more Raman spectral features are detected in the collected probe light, a pH of the sub-surface volume can be determined from the spectral features.Type: GrantFiled: October 27, 2017Date of Patent: March 9, 2021Assignee: UNITED KINGDOM RESEARCH AND INNOVATIONInventors: Pavel Matousek, Nicholas Stone, Benjamin Gardner
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Patent number: 10942124Abstract: The present disclosure provides a surface enhanced Raman scattering substrate assembly for detecting an analyte. The assembly can include an etched fiber base. The assembly can further include a metallic nanoparticle coating disposed over at least a portion of the surface etched fiber base.Type: GrantFiled: June 12, 2019Date of Patent: March 9, 2021Assignee: University of MassachusettsInventors: Lili He, Haoxin Chen, Zhuangsheng Lin
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Patent number: 10935493Abstract: The present invention relates to a method for detecting the presence of gas hydrates and/or ice in a medium. The method comprises at least the following steps: measuring at least at one measurement point in said medium two characteristic values of Raman spectra corresponding to two distinct vibration modes of the OH bonds of water, and determining the ratio ? of said two characteristic values, determining the temperature T in said medium at said measurement point of said spectra, comparing ratio ? with a value ?0 corresponding to a predetermined threshold of formation of said crystals for said temperature T, and determining the presence or not of hydrate and/or ice crystals from said comparison.Type: GrantFiled: November 30, 2017Date of Patent: March 2, 2021Assignee: IFP ENERGIES NOUVELLESInventors: Olivier Delpoux, Didier Frot, Anne Sinquin, Corinne Sagnard, Veronique Lachet
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Patent number: 10935496Abstract: A chemical analyte sensor. The sensor has a monolayer of shaped nanostructures, a metal or metallized surface, and analyte confined between the monolayer of shaped nanostructures and the metal or metallized surface. The analyte is confined in the highly absorbing optical cavity of the metasurface defined at the metal or metallized surface.Type: GrantFiled: April 18, 2019Date of Patent: March 2, 2021Assignee: The Regents of the University of CaliforniaInventors: Andrea Tao, Tyler Dill, Andrea Rodarte
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Patent number: 10921295Abstract: Systems and methods are described to provide speciation of silicon species present in a remote sample for analysis. A method embodiment includes, but is not limited to, receiving a fluid sample containing inorganic silicon in the presence of bound silicon from a remote sampling system via a fluid transfer line; transferring the fluid sample to an inline chromatographic separation system; separating the inorganic silicon from the bound silicon via the inline chromatographic separation system; transferring the separated inorganic silicon and bound silicon to a silicon detector in fluid communication with the inline chromatographic separation system; and determining an amount of one or more of the inorganic silicon or the bound silicon in the fluid sample via the silicon detector.Type: GrantFiled: August 31, 2018Date of Patent: February 16, 2021Assignee: ELEMENTAL SCIENTIFIC, INC.Inventors: Jacob Unnerstall, Patrick Sullivan, Daniel R. Wiederin, Brad Prucha, C. Derrick Quarles, Jr., Jae Seok Lee
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Patent number: 10921187Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.Type: GrantFiled: March 12, 2019Date of Patent: February 16, 2021Assignee: Pendar Technologies, LLCInventors: Daryoosh Vakhshoori, Romain Blanchard, Peili Chen, Masud Azimi, Tobias Mansuripur, Kalyani Krishnamurthy, Arran M. Bibby, Fred R. Huettig, III, Gokhan Ulu, Greg Vander Rhodes
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Patent number: 10914684Abstract: An in-situ photocatalysis monitoring system based on surface-enhanced Raman Scattering (SERS) spectroscopy. The monitoring system may include a Raman excitation light source, a laser coupling lens, a narrow band filter, a total reflection mirror, a dichroic mirror, a focusing coupling lens, a SERS optical fiber probe, a liquid phase photocatalysis reactor, a photocatalytic light source, a Raman collection lens, and a spectrometer. A first furcation part and a second furcation part each extend from one end of a common detection part of the SERS optical fiber probe; an extending end of the first furcation part is coupled with the focusing coupling lens; an extending end of the second furcation part is coupled with the photocatalytic light source; and the other end of the common detection part is arranged inside the liquid phase photocatalysis reactor. Raman excitation light and photocatalytic light may be transmitted on a common channel.Type: GrantFiled: May 24, 2019Date of Patent: February 9, 2021Assignee: DONGGUAN UNIVERSITY OF TECHNOLOGYInventors: Fei Zhou, Ye Liu, Dongxiong Ling, Hongcheng Wang
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Patent number: 10907122Abstract: An apparatus and related method for determining the optical density and/or change in optical density of a reaction mixture in an agitated vessel or container. The apparatus may include at least one electromagnetic emitter configured to pass radiation through the reaction mixture to at least one receptor, whereby the receptor receives the transmitted or scattered light, while the reaction mixture is subjected to shaking. The emitters may have an interchangeable association with the vessel or container and/or the receptors may have an interchangeable association with the vessel or container. Further, a processor may be provided to receive the transmitted or scattered light data and filter to eliminate or reduce the effect of the frequency at which the reaction mixture is shaken. The processor analyzes the filtered data to provide the optical density and/or change in optical density of the reaction mixture.Type: GrantFiled: April 29, 2016Date of Patent: February 2, 2021Assignee: University of Virginia Patent FoundationInventors: Jason A. Papin, Bonnie V. Dougherty, Alisha Mae Geldert, Kevin P. Seitter
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Patent number: 10900904Abstract: The present invention relates to a method for detecting moisture and volatile matter content in raw coal using the value of baseline drift, comprising the following steps: selecting a plurality of types of standard coal having different coal ranks and different ash contents, performing a Raman spectroscopy test and a proximate analysis on each type of standard coal, calculating the value of baseline drift in the Raman spectrum, and setting up the mapping relationship between the value of baseline drift in the Raman spectrum and the characteristic parameters of the moisture and the volatile matter content. The same method and reference are used to perform a Raman spectroscopy test on raw coal to be tested, so as to calculate the value of baseline drift in a Raman spectrum of the raw coal to be tested, and obtain the moisture and volatile matter content of the raw coal to be tested.Type: GrantFiled: March 28, 2018Date of Patent: January 26, 2021Assignee: HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Jun Xiang, Jun Xu, Sheng Su, Song Hu, Yi Wang, Jiawei Liu, Zhe Xiong, Jing Zhou, Hao Tang, Mengxia Qing, Wei Liu
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Patent number: 10890525Abstract: An infrared (IR) sensor and a method of detecting molecular species in a liquid. In one embodiment, the IR sensor includes: (1) an IR light source configured to emit IR light, (2) a sensing element configured to receive the IR light, the IR light generating an evanescent field about the sensing element as the IR light propagates therethrough, molecules in a subject liquid interacting with the evanescent field and affecting a characteristic of the IR light and (3) an IR light detector configured to receive the IR light from the sensing element and detect the characteristic.Type: GrantFiled: February 19, 2020Date of Patent: January 12, 2021Assignee: Max-IR Labs, LLCInventor: Ecatherina Roodenko
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Patent number: 10892575Abstract: An electronic component includes a first substrate including first connection terminals in an end region on a first surface; and a second substrate including second connection terminals on a first surface, the second connection terminals being disposed at a position corresponding to the first connection terminals. Each of the first connection terminals includes a base and an elastic contact piece extending from the base. The elastic contact piece is elastically deformable in a direction in which the tip end portion thereof approaches and departs with respect to the base. The first connection terminals are electrically connected to the second connection terminals while having the first surface of the first substrate being opposed to the first surface of the second substrate, and the second connection terminals being pressed onto the elastic contact pieces.Type: GrantFiled: December 18, 2019Date of Patent: January 12, 2021Assignee: LENOVO (SINGAPORE) PTE. LTD.Inventors: Hirohide Komiyama, Jun Kaminaga, Kenji Watamura
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Patent number: 10883930Abstract: An infrared (IR) sensor and a method of detecting molecular species in a liquid. In one embodiment, the IR sensor includes: (1) an IR light source configured to emit IR light, (2) a sensing element configured to receive the IR light, the IR light generating an evanescent field about the sensing element as the IR light propagates therethrough, molecules in a subject liquid interacting with the evanescent field and affecting a characteristic of the IR light and (3) an IR light detector configured to receive the IR light from the sensing element and detect the characteristic.Type: GrantFiled: June 5, 2019Date of Patent: January 5, 2021Assignee: Max-IR Labs, LLCInventor: Ecatherina Roodenko
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Patent number: 10876973Abstract: A remote SERS spectrum detection system and a method thereof. The system includes: a pulsed laser light source, configured to emit Raman excitation light; an optical fiber Raman coupling module, configured to couple the Raman excitation light; the optical fiber Raman probe, configured to transmit the Raman excitation light to an object to be measured to generate a SERS signal light, a backscattered SERS signal light being coupled to a monochromator through the optical fiber Raman coupling module; the monochromator, configured to split the backscattered SERS signal light, to obtain backscattered SERS signal lights at different wavelengths; a high-speed photodetector, configured to convert the backscattered SERS signal lights into time-resolved electrical signals; a processor, for analyzing electrical signals, retrieving a SERS spectrum of the remote object to be measured, and controlling automatic scanning of a grating in the monochromator to achieve clock synchronization.Type: GrantFiled: January 17, 2020Date of Patent: December 29, 2020Assignee: Dongguan University Of TechnologyInventors: Ye Liu, Fei Zhou, Hongcheng Wang
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Patent number: 10866189Abstract: In multicolor Coherent anti-Stokes Raman Scattering, a fingerprint region is a region densely filled with signals, and information about an intensity or spatial distribution of the signals is important for cell analysis. However, when laser power was increased due to the low signal intensity, there was a problem that cells were damaged. Thus, the present invention was configured such that the number of pulses of laser light emitted from a short pulse laser light source was changed by a pulse modulator. Accordingly, damage to the cells can be suppressed without significant reduction in signal intensity.Type: GrantFiled: November 24, 2015Date of Patent: December 15, 2020Assignee: Hitachi, Ltd.Inventors: Manabu Shiozawa, Kakuro Hirai
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Patent number: 10859500Abstract: Embodiments of the present disclosure provide plasmonic structures, methods of making plasmonic structures, and the like.Type: GrantFiled: April 17, 2017Date of Patent: December 8, 2020Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATEDInventors: Wei David Wei, Jingjing Qiu
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Patent number: 10855046Abstract: Phase modulated Optical Parametric Amplification Imaging (p-OPA), can be used to determine the magnitude and the sign of the second-order nonlinear susceptibility of a material, and its spatial variation.Type: GrantFiled: October 13, 2018Date of Patent: December 1, 2020Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: William A. Tisdale, Yunan Gao, Aaron Jacob Goodman
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Patent number: 10852231Abstract: The invention provides a method of analyzing a liquid sample, comprising the steps of: passing near-infrared light through the sample, wherein the light travels in metal nanoparticles-added microfiber that is immersed in the sample; obtaining spectral information across a wavelength range of about 750 nm to about 1800 nm; and qualitatively identifying, and optionally quantitatively characterizing, one or more analytes in the sample. Near-infrared spectrophotometer carry out the method is also provided by the invention.Type: GrantFiled: June 25, 2017Date of Patent: December 1, 2020Assignee: B.G. Negev Technologies and Applications Ltd., at Ben-Gurion UniversityInventor: Alina Karabchevsky