By Light Patents (Class 356/317)
  • Patent number: 10393587
    Abstract: Methods for laser induced ablation spectroscopy are disclosed. A sample site position sensor, and stage position motors can move the stage in three independent spatial coordinate directions, and a stage position control circuit is used to move an analysis sample site to selected coordinate positions for laser ablation. Light emitted from a plasma plume produced with laser ablation can be gathered into a lightguide fiber bundle that is subdivided into branches. One branch can convey a first portion of the light to a broadband spectrometer operable to analyze a relatively wide spectral segment, and a different branch can convey a second portion of the light to a high dispersion spectrometer operable to measure minor concentrations and/or trace elements. Emissions from a plasma plume can be simultaneously analyzed in various ways using a plurality of spectrometers having distinct and/or complementary capabilities.
    Type: Grant
    Filed: July 3, 2016
    Date of Patent: August 27, 2019
    Assignee: Applied Spectra, Inc.
    Inventors: Jong Hyun Yoo, Randolph S. Tribe, Chunyi Liu
  • Patent number: 10386338
    Abstract: The present invention relates to a piezoelectric mechanical system (PEMS) microcantilever sensor that both detects the presence of viral RNA in an aqueous solution, such as a blood sample. The method provides for the formation of the sensor by attaching RNA, DNA, or an antibody to the microcantilever sensor surface via a hydrazone or an oxime chemical bond. The method provides for the detection of viral RNA viruses and viral DNA viruses upon the chemical binding/bonding of single-stranded viral nucleic acid to the microcantilever sensor surface. The method provides for the detection of DNA cancer mutations or variants that have been identified in a cancer cell upon the chemical binding/bonding of single-stranded DNA to the microcantilever sensor surface.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: August 20, 2019
    Inventor: Cynthia Rena Wright
  • Patent number: 10379047
    Abstract: Embodiments of a cell culture monitoring system are disclosed that may include a device having collimating and filtering components to elicit and detect fluorescence from a substrate located within a reaction vessel. The device may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells. Excitation light beams can be generated and collimated by a beam combiner and directed into the reaction vessel so as to be incident upon the substrate to cause the substrate to fluoresce. Some embodiments include use of expected wavelength offsets and shifted filters/mirrors to improve functionality and reduce space of device components.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: August 13, 2019
    Assignee: Scientific Industries, Inc.
    Inventors: Michael Tolosa, William Chandler, Douglas J. Koebler, Joseph G. Cremonese, Brookman P. March
  • Patent number: 10371700
    Abstract: An in-vitro diagnostic includes a housing, a storage, and a blocking agent. The housing houses a liquid including a test substance included in a sample extracted from a subject. The storage stores a substance that specifically reacts with the test substance. The blocking agent is placed to separate the container and the storage.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: August 6, 2019
    Assignee: Canon Medical Systems Corporation
    Inventors: Asuka Hirano, Shoichi Kanayama, Ichiro Tono
  • Patent number: 10365273
    Abstract: Provided is a fluorescence immunoassay sensor chip and a fluorescence immunoassay method, which are capable of measuring, at the same time, a marker requiring high sensitivity due to its low content in a sample solution and a marker not requiring high sensitivity due to its high content in a sample solution. The fluorescence immunoassay sensor chip for use in fluorescence immunoassay for detecting and measuring markers contained in a sample solution includes: a dielectric member; a metal thin film formed on part of a main surface of the dielectric member; a first sensor part formed in a predetermined position on the metal thin film; and a second sensor part directly formed in a predetermined position on the dielectric member, wherein a ligand immobilized in the first sensor part and a ligand immobilized in the second sensor part capture different types of markers.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: July 30, 2019
    Assignee: KONICA MINOLTA, INC.
    Inventors: Makiko Ootani, Tsuruki Tamura, Shinichi Muramatsu
  • Patent number: 10330597
    Abstract: Apparatus for enhancing on-chip fluorescence detection. For example, an apparatus comprises a microfluidic channel, an excitation signal enhancing structure formed on a first side of the microfluidic channel and a photodetector structure formed on a second side of the microfluidic channel. For example, the excitation signal enhancing structure enhances an excitation signal and the enhanced excitation signal excites one or more samples in the microfluidic channel to emit signals at a fluorescence wavelength at a higher rate.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: June 25, 2019
    Assignee: International Business Machines Corporation
    Inventors: Yann Andre Nicolas Astier, Ning Li, Devendra K. Sadana, Chao Wang
  • Patent number: 10310248
    Abstract: Provided is a microscope including: a chamber storing a solution in which a cuvette accommodating a solution together with a sample is immersed and that has an index of refraction identical to that of the solution; an immersion objective lens being placed outside the chamber and collecting light from the sample; a camera acquiring an image of the light collected by the lens; a targeting section moving the lens in a direction along a detection light axis thereof; and a movable stage supporting the cuvette in the chamber so as to be movable in at least a direction along the detection light axis. Each of the cuvette and the chamber has a transparent section that can transmit light coming from the sample. The lens is placed so as to face the transparent section of the cuvette with the transparent section of the chamber interposed therebetween.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: June 4, 2019
    Assignee: OLYMPUS CORPORATION
    Inventors: Brendan Brinkman, Yoshihiro Shimada
  • Patent number: 10271720
    Abstract: The present invention provides an intraoral imaging and illumination apparatus comprising a rear portion and a front portion removably connected to the rear portion. The front portion is formed as a light guide. The rear portion comprises an imaging device and an illumination device. The illumination device is adapted to couple light into the front portion and towards a leading end of the front portion opposite the rear portion so as to illuminate a first object. The imaging device is adapted to image the first object.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: April 30, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Johannes Fink, Guenter Zilligen, David M. Rudek
  • Patent number: 10257480
    Abstract: A projection display apparatus that can prevent deviation in the light quantity distribution of the projected image is provided. A projection display apparatus includes: a light source unit including a light emitting element; an image light generator modulating light from the light source unit to emit image light; a projecting unit projecting the image light; a polarization modulator on which the image light is made incident and that emits light in a particular polarization state; and a depolarizer arranged on the optical path between the light emitting element and the polarization modulator.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: April 9, 2019
    Assignee: NEC DISPLAY SOLUTIONS, LTD.
    Inventor: Shinichiro Chikahisa
  • Patent number: 10222337
    Abstract: Methods for laser induced ablation spectroscopy are disclosed. A position sensor, and position motors can move a sample stage in three independent spatial coordinate directions, and a stage position control circuit can move an analysis sample site to selected coordinate positions for ablation. Light from laser ablation can be gathered into a lightguide fiber bundle that is subdivided into branches. One branch can convey a first portion of the light to a broadband spectrometer operable to analyze a relatively wide spectral segment, and a different branch can convey a second portion of the light to a high dispersion spectrometer operable to measure minor concentrations and/or trace elements. Emissions can be simultaneously analyzed in various ways using a plurality of spectrometers having distinct and/or complementary capabilities, and isotope analysis of a sample can be performed.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: March 5, 2019
    Assignee: Applied Spectra, Inc.
    Inventors: Jong Hyun Yoo, Chunyi Liu, Alexander A. Bol'shakov, Richard E. Russo, Xianglei Mao, Randolph S. Tribe, Osman Sorkhabi
  • Patent number: 10209197
    Abstract: A method for inspecting an aging state of a silicone rubber composite insulating material comprises the following steps: bombarding, for multiple times and by a pulsed laser beam, selected points on a surface of a silicone rubber composite insulating material to be inspected to generate a plasma; collecting spectrum information emitted by the plasma at each bombardment, and extracting, from the collected spectrum information, a spectral property indicator of a specific constituent element of the silicone rubber composite insulating material at each bombardment; and determining aging state information of the silicone rubber composite insulating material according to the change pattern of the spectral property indicator of the specific constituent element with respect to the bombardment depth. The method enables the rapid and accurate inspection of an aging state of a silicone rubber composite insulating material, and avoids the destructive tests required in the prior art.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: February 19, 2019
    Assignee: GRADUATE SCHOOL AT SHENZHEN, TSINGHUA UNIVERSITY
    Inventors: Xilin Wang, Han Wang, Weian Ye, Zhidong Jia
  • Patent number: 10073256
    Abstract: An apparatus for imaging a sample arranged in a first medium in an object plane. The apparatus includes an optical transmission system which images the sample in the object plane in an intermediate image in an intermediate image plane. The object plane and the intermediate image plane form an angle not equal to 90° with an optical axis of the transmission system. The apparatus further comprises an optical imaging system having an objective. The object plane may be imaged on a detector without distortion. The optical transmission system is symmetrical with respect to a pupil plane, the object plane, and the intermediate image plane to satisfy the Scheimpflug condition. The intermediate image lies in a second medium having a refractive index virtually identical to that of the first medium. A lens group of a subsystem arranged closest to the sample or intermediate image comprises at least one catadioptric assembly.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: September 11, 2018
    Assignees: CARL ZEISS MICROSCOPY GMBH, CARL ZEISS AG
    Inventors: Wolfgang Singer, Ralf Wolleschensky, Wilhelm Ulrich, David Shafer, Artur Degen
  • Patent number: 10060795
    Abstract: A problem addressed by the present invention is to reduce the influence of stray light incident on each light-receiving element in the case of receiving each wavelength of light using a plurality of light-receiving elements.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: August 28, 2018
    Assignee: Shimadzu Corporation
    Inventors: Masahide Gunji, Akira Noda, Kensuke Otake
  • Patent number: 10060975
    Abstract: A semiconductor device inspection system (1) includes a laser beam source (2), for emitting light, an optical sensor (12) for detecting the light reflected by the semiconductor device (10) from the light and outputting a detection signal, a frequency band setting unit (16) for setting a measurement frequency band and a reference frequency band with respect to the detection signal, a spectrum analyzer (15) for generating a measurement signal and a reference signal from the detection signals in the measurement frequency band and the reference frequency band, and a signal acquisition unit (17) for calculating a difference between the measurement signal and the reference signal to acquire an analysis signal. The frequency band setting unit (16) sets the reference frequency band to a frequency domain in which a level of the detection signal is lower than a level obtained by adding 3 decibels to a white noise level serving as a reference.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: August 28, 2018
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventor: Tomonori Nakamura
  • Patent number: 10054483
    Abstract: Aspects of a micromirror spectrophotometer assembly are described. In one example case, an instrument includes a diffraction grating to disperse broadband light over a range of wavelengths, a detector, a digital micromirror device (DMD) configured to scan through and reflect at least a portion of the range of wavelengths toward the detector, and a base platform having a number of integrally formed assembly mounts. The assembly mounts are formed to align and secure the diffraction grating, the detector, the DMD, and other optical components of the instrument in a predetermined arrangement. The instrument can also include a reference paddle having a reference material for calibration of the instrument, and a rotatable sample tray to rotate a sample placed on the sample tray for measurement.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: August 21, 2018
    Assignee: WESTCO SCIENTIFIC INSTRUMENTS, INC
    Inventors: Jerome J. Workman, Jr., John Coates, David Naranjo
  • Patent number: 10041464
    Abstract: A controller of a laser ignition engine configured to perform ignition by using a laser ignition device configured to emit a laser beam condensed by a lens includes: a combustion state related value acquiring portion configured to acquire a combustion state related value related to a combustion state of the engine; and a contamination determining portion configured to compare the combustion state related value acquired by the combustion state related value acquiring portion with a combustion state determining value to determine whether or not the laser ignition device is contaminated, the combustion state determining value being defined based on the combustion state of the engine when the laser ignition device is not contaminated.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: August 7, 2018
    Assignee: Mazda Motor Corporation
    Inventors: Takashi Youso, Masahisa Yamakawa, Tatsuya Fujikawa, Atsushi Inoue
  • Patent number: 10007100
    Abstract: A light sheet illumination microscope includes a detection optical system and an illumination optical system. The illumination optical system includes a first optical element for forming a sheet-shaped illumination beam that travels in a first direction and that has a width in a second direction that is perpendicular to both the optical axis of the detection optical system and the first direction in a specimen, and a scanner that relatively scans the specimen with the sheet-shaped illumination beam in the second direction.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: June 26, 2018
    Assignee: OLYMPUS CORPORATION
    Inventor: Yu Kikuchi
  • Patent number: 9983125
    Abstract: The present invention relates to a system for detecting terahertz radiation, a camera device, and a method for detecting terahertz radiation.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: May 29, 2018
    Assignee: Danmarks Tekniske Universitet
    Inventors: Krzysztof Iwaszczuk, Peter Uhd Jepsen
  • Patent number: 9963732
    Abstract: One or more live substances is cultured at a plurality of test locations of a test vessel. The test locations include a thermochromic material and one or more test substances. A spectral shift in light emanating from the thermochromic material of the test locations is detected. The spectral shift occurs in response to an increase or decrease in energy conversion by the live substance. An effect of the one or more test substances on the live substances is determined based on the detected spectral shift.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: May 8, 2018
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Joerg Martini, Michael I. Recht, Peter Kiesel
  • Patent number: 9952148
    Abstract: In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing radiation scattered from the material in response to the illumination. For example, in some embodiments, a material can be illuminated with polarized radiation at a plurality of wavelengths and the elastically scattered radiation corresponding to two or more of those wavelengths can be collected at two polarizations: one parallel and the other perpendicular to the illumination polarization. A differential intensity of the scattered radiation at the two polarizations can be analyzed as a function of wavelength to obtain information regarding the morphology of mineral deposits in the sample. Further, the total scattered radiation can be analyzed to derive information regarding the level of mineralization.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: April 24, 2018
    Assignee: Trustees of Tufts College
    Inventors: Irene Georgakoudi, Sharad Gupta, Martin Hunter, David L. Kaplan
  • Patent number: 9932956
    Abstract: A laser ignition device for an internal combustion engine can include a laser generator, a housing, and a window. The laser generator can emit a pulse of laser light. The housing can be coupled to the internal combustion engine. The housing can have a first end and a second end. The second end can be proximate to a combustion chamber of the internal combustion engine and can define an aperture through which the laser light is permitted to exit the housing into the combustion chamber. The window can be coupled to the second end of the housing and cover the aperture. The window can permit the laser light to pass through the window and into the combustion chamber. The window can have a rounded outer surface.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: April 3, 2018
    Assignees: DENSO International America, Inc., DENSO CORPORATION
    Inventors: Jeongung Hwang, Christopher Thomas, Nicholas C. Polcyn
  • Patent number: 9872643
    Abstract: A non-intrusive physiological data measurement system and method, as well as an optically induced treatment system, are described. The measurement system includes a monitoring mechanism that includes light emitter modules capable of emitting light at at least two wavelengths. The light emitted from the light emitter modules is transmitted through a subject and to a light receiving mechanism, such as an optical sensor. Physiological data is taken from the received light. The system also can ascertain movement of the subject by obtaining an initial outline of the subject and comparing that outline with a subsequently obtained outline. A therapeutic optic system includes a non-adhering light emitting mechanism for providing light at therapeutic wavelengths.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: January 23, 2018
    Assignee: General Electric Company
    Inventors: Michael Joseph Mahony, John Erik Hershey, Glenn Alan Forman, Harold Woodruff Tomlinson, Jr., William Eugene Powell, III
  • Patent number: 9863810
    Abstract: An optical device includes: a diffraction grating; a depolarization plate containing a birefringent material to eliminate polarization dependency of the diffraction grating; and an optical corrector configured to optically correct diffraction angle deviation of diffracted light due to diffraction at the diffraction grating. The optical corrector may be configured to bend back the diffracted light diffracted by the diffraction grating to re-emit the light to the diffraction grating.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: January 9, 2018
    Assignees: Yokogawa Electric Corporation, YOKOGAWA TEST & MEASUREMENT CORPORATION
    Inventors: Tsutomu Kaneko, Manabu Kojima
  • Patent number: 9855558
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: January 2, 2018
    Assignee: APPLIED BIOSYSTEM, LLC
    Inventors: Hon Siu Shin, Hock Lai Khoo
  • Patent number: 9835557
    Abstract: A device and system for measuring the multidimensional distribution of a sample tagged with a short life fluorescent label. The substance applied to a sample holder can be scanned with an optical point source excitation and read back optical stage. The sample can be excited at each of a plurality of points with a fast, e.g., nanosecond pulse of light. The resulting fluorescence can be detected after the excitation is extinguished. A detection gate window can be optimized to maximize the fluorescence signal detected for a predetermined amount of time.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: December 5, 2017
    Assignee: GENECAPTURE, INC.
    Inventor: Marc L Pusey
  • Patent number: 9833475
    Abstract: Techniques and devices for removing (filtering out) unwanted/inhibitory components (for example, products, byproducts and/or cell output such as inhibitory catabolic proteins) from a composition (for example, autologous fluid or serum) containing such unwanted/inhibitory components. The devices include at least one construct designed to contain a composition (for example, autologous fluid or serum) containing inhibitory/unwanted components (products, byproducts and/or output of cells such as inhibitory catabolic proteins). The construct is provided with interior walls including specific protein capturing means designed to remove the inhibitory/unwanted component(s) (for example, specific protein(s)) from the composition. Proteins targeted for capture include, but are not limited to, catabolic cytokines such as IL-1?, IL-?, IL-6, TNF?, IFN? and MMPS as these proteins inhibit the healing process.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: December 5, 2017
    Assignee: ARTHREX, INC.
    Inventors: Christopher M. Bare, Brandon L. Roller, Melissa S. Tucker
  • Patent number: 9823243
    Abstract: An object of the present invention is to provide a highly sensitive immunoanalysis method and analysis apparatus. The invention relates to an analysis method and an analysis apparatus which are constituted in such a way that a component to be measured is reacted with capture component specifically reacting thereto and the reactant is labeled when the component to be measured is present and which are characterized by analyzing the component to be measured with single-molecule sensitivity and resolution by arranging the labeled reactant in a spatially separated certain position and detecting the label of the labeled reactant.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: November 21, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kyoko Imai, Toshiro Saito, Kazumichi Imai
  • Patent number: 9823195
    Abstract: An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: November 21, 2017
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Mark F. Oldham, Eugene F. Young
  • Patent number: 9801578
    Abstract: Optical systems are disclosed for use in identifying an analyte, such as glucose in blood or interstitial fluid (ISF), using a biomaterial, such as glucose binding protein (GBP), that is brought into contact with the analyte. An optical system includes a first filter adapted to reflect light emitted from a light-emitting diode to illuminate a fluorescent body, and further adapted to transmit light emitted from the fluorescent body, and a second filter adapted to separate light transmitted by the first filter into signal band light and reference band light.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: October 31, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: Aaron Weber, David Tracy, James Salemme, John Prudden
  • Patent number: 9726636
    Abstract: According to one embodiment, provided is a single particle analyzing device including a measuring vessel, first and second chambers in the vessel defined by an insulating membrane, a pore opening in the membrane to connect the chambers, and first and second electrodes in the chambers. Electric current flows between the electrodes through the pore. Electrical characteristics are measured during migration of the target from the first chamber to the second chamber to measure the size and shape of the target. (a) t<a <d?100a or (b) s<L, s<d?100s, t<L and t<d, wherein a, L and s are the diameter, length and width of the target, d is the diameter of the pore, and t is the thickness of the membrane in the proximity to the pore.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: August 8, 2017
    Assignees: KABUSHIKI KAISHA TOSHIBA, OSAKA UNIVERSITY
    Inventors: Sadato Hongo, Tomoji Kawai, Makusu Tsutsui, Masateru Taniguchi, Soh Ryuzaki
  • Patent number: 9696206
    Abstract: In a terahertz-wave spectrometer, a spectroscopic prism is provided with a prism part slidable with respect to a main part thereof. Along the sliding direction, an arrangement surface in an upper face of the prism part is provided with a plurality of arrangement regions K to be arranged with objects to be measured. Therefore, after completing the measurement of optical constants for one object, the prism part is slid, so as to shift the next object onto an optical path of a terahertz wave T, whereby a plurality of objects can be measured smoothly without cleaning the arrangement surface.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: July 4, 2017
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Takashi Yasuda, Kouichiro Akiyama, Yoichi Kawada, Atsushi Nakanishi, Hironori Takahashi
  • Patent number: 9690086
    Abstract: A widefield microscope illumination system and method with a microscope objective and an illumination light source that sends widefield illumination light along illumination beam paths. Illumination light penetrates into the microscope objective through illumination light entry sites located within a predetermined annular or annular-segment-shaped illumination light entry area having a large offset to an optical objective axis of the objective. A spatially resolving light detector detects light sent from an illuminated sample through the microscope objective along a detected light beam path. An automatic illumination light beam path manipulation device is controlled by a control system, which is arranged in front of the microscope objective in relation to the direction of the illumination light beam path, and by means of which illumination light beam path manipulation device the illumination axes are automatically movable at time intervals to a plurality of different illumination light entry sites.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: June 27, 2017
    Assignee: Leica Microsystems CMS GmbH
    Inventor: Jonas Foelling
  • Patent number: 9678012
    Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing the emission energy towards a sensor within the pixel. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: June 13, 2017
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyarfas, Jeremy Lackey, Gerard Schmid, Lawrence C. West, Keith G. Fife, Benjamin Cipriany, Farshid Ghasemi
  • Patent number: 9664342
    Abstract: An optoelectronic component device includes a plurality of optoelectronic components that provide and/or absorb electromagnetic radiation; a reflector arranged in a beam path of the electromagnetic radiation of the plurality of optoelectronic components and which has a surface that is at least partly reflective with respect to the provided electromagnetic radiation; wherein the plurality of optoelectronic components at least partly surround the reflector or are at least partly surrounded by the reflector; and the reflector reflects a provided electromagnetic radiation such that a predefined field distribution of the reflected electromagnetic radiation is formed in the image plane of the optoelectronic component device.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: May 30, 2017
    Assignee: OSRAM Opto Semiconductors GmbH
    Inventors: Stephan Kaiser, Tony Albrecht, Michael Bestele, Jan Marfeld, Albert Schneider, Markus Kirsch
  • Patent number: 9658335
    Abstract: The present invention relates to a measurement system 50 having a measuring device 20 and a scanning module 10 which has: a fastening means for fastening the scanning module 10 onto a holder; a beam deflection element 11 that is rotatable by a motor about an axis of rotation 12 to deflect a scanning laser beam 60, wherein the axis of rotation 12 is arranged at a defined angle relative to the pivoting axis 22; and a second angle measurement functionality 13 for determining an angle of rotation from an angle position of the beam deflection element 11. In addition, the measuring device 20 has a holder designed such that the scanning module 10 can be fastened by means of the fastening means in a module-like manner in a defined position on the measuring device 20.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: May 23, 2017
    Assignee: HEXAGON TECHNOLOGY CENTER GMBH
    Inventors: Knut Siercks, Bernhard Metzler
  • Patent number: 9658222
    Abstract: A cartridge for processing a sample includes (a) a planar waveguide with upper and lower planar surfaces defining an optical axis therebetween, wherein the upper planar surface has a plurality of capture molecules bound thereto, (b) a lens portion, coupled to the planar waveguide, for focusing and refracting a light beam propagating parallel to, but offset from, the optical axis such that the light beam couples into the planar waveguide and propagates therein along the optical axis at a non-zero, internal propagation angle ? relative to the upper planar surface, and (c) a sample chamber for positioning the sample in contact with the plurality of capture molecules such that a target analyte of the sample is detectable through (i) an assay involving the target analyte and the capture molecules and (ii) evanescent illumination of the assay using the light beam within the planar waveguide.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: May 23, 2017
    Assignee: Mbio Diagnostics, Inc.
    Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher J. Myatt
  • Patent number: 9625322
    Abstract: Provided is an antenna module that comprises an antenna comprising a radiation patch for transmitting or receiving the terahertz wave, and a first ground disposed away from the radiation patch, the first ground having a hole, an integrated circuit board having a signal processing unit configured to generate the terahertz wave or to process the terahertz wave received through the antenna, the integrated circuit board being disposed under the antenna and a via configured to connect the radiation patch with the signal processing unit, the via passing through the hole.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: April 18, 2017
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Sang-Gug Lee, Sun-A Kim, Kyoung-Young Choi, Dae-Woong Park, Seok-Kyun Han
  • Patent number: 9618449
    Abstract: Modular systems can be used for optical analysis, including in-situ analysis, of stimulated liquids. An excitation module can include a radiation sources, e.g., a laser, LED, lamp, etc. A detection module can include one or more detectors configured to receive spectral and/or temporal information from a stimulated liquid. Such systems can be used to identify or measure optical emissions including fluorescence or scattering. The efficient excitation of liquid samples and collection of emissions from the samples provides substantial, up to four-fold increase in the emission signal over prior systems. In an example, emission measurements can be conducted in an isolated sample compartment, such as using interchangeable modules for discrete sampling, flow-through sampling, or sampling via fiber probe. The systems and methods described herein can be used to characterize natural aquatic environments, including assessments of phytoplankton pigments, biomass, structure, physiology, organic matter, and oil pollution.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: April 11, 2017
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Alexander Chekalyuk
  • Patent number: 9618450
    Abstract: An optical sensor may include multiple optical emitters configured to emit light into a fluid sample via an optical pathway. Light from the emitters can cause fluorescence from the sample and/or scatter off of the sample. Scattered and fluoresced light can be received by an optical detector in the sensor via the optical pathway, and used to determine at least one characteristic of the fluid sample. A second optical detector can provide reference measurements of the amount of light emitted to the sample. In one example, the optical detector can detect scattered and fluoresced light simultaneously. In another example, light is emitted and detected alternatingly. The sensor can be part of a system that includes one or more controllers configured to control the emitting and detecting of light to and from the fluid sample. The controller can use detected light to determine at least one characteristic of the fluid sample.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: April 11, 2017
    Assignee: ECOLAB USA, INC.
    Inventors: Rodney H. Banks, Eugene Tokhtuev
  • Patent number: 9575302
    Abstract: Aberrations in stimulated emission depletion microscopy are corrected using an adaptive optics approach using a metric which combines both image sharpness and brightness. Light modulators (22,32) are used to perform aberration correction in one or more of the depletion path (10), the excitation path (12), or the emission path from sample to detector.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: February 21, 2017
    Assignee: ISIS Innovation Ltd
    Inventors: Martin Booth, Daniel Burke, Joerg Bewersdorf, Travis J. Gould
  • Patent number: 9564731
    Abstract: A method of providing supercontinuum illumination in applications involving the excitation of fluorescence, comprising generating, at an optical pump laser, optical pump pulses at a pump pulse repetition rate; selectively controlling with an optical modulator the launch of pump pulses into a nonlinear optical element comprising an optical fiber at a variable, lower repetition rate to thereby selectively control the repetition rate of supercontinuum pulses generated within the optical fiber; and illuminating a sample with supercontinuum pulses to excite fluorescence. The supercontinuum pulses can be wavelength filtered such that the fluorescence is excited with wave length filtered supercontinuum pulses.
    Type: Grant
    Filed: March 10, 2013
    Date of Patent: February 7, 2017
    Assignee: Fianium Ltd.
    Inventors: John Redvers Clowes, Anatoly Borisovich Grudinin, Ian Michael Godfrey
  • Patent number: 9562862
    Abstract: Optical and chemical analytical systems and methods are provided herein. In one embodiment, a method includes exposing a mixture sample to electromagnetic radiation, the mixture sample including analytes, detecting responsiveness of one or more of the analytes to the electromagnetic radiation, calculating average responsiveness of the one or more of the analytes, and calculating a concentration of the one or more of the analytes in the mixture sample using the average responsiveness.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: February 7, 2017
    Assignee: H2Optx Inc.
    Inventors: Rudy Hofmeister, Scott Tandy, Donald Ice
  • Patent number: 9545689
    Abstract: Temporal focusing of spatially chirped femtosecond laser pulses overcomes previous limitations for ablating high aspect ratio features with low numerical aperture (NA) beams. Simultaneous spatial and temporal focusing reduces nonlinear interactions, such as self-focusing, prior to the focal plane so that deep (˜1 mm) features with parallel sidewalls are ablated at high material removal rates.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: January 17, 2017
    Assignee: Colorado School of Mines
    Inventors: Jeffrey Squier, Dawn Vitek, Charles Durfee, Daniel Adams, David Kleinfeld
  • Patent number: 9496955
    Abstract: A signature encoded light system includes at least one light source. The at least one light source is configured to output a first encoded light signature embedded within light in the visible spectrum. A light signature detection device is configured to receive a composite light signal formed with light from the at least one light source and ambient light. The light signature detection device is configured to identify the first encoded light signature.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: November 15, 2016
    Assignee: eocys, LLC
    Inventors: Ethan Michael O'Connor, Shannon Yun-Ming Cheng
  • Patent number: 9446404
    Abstract: Droplet actuator apparatus and system are provided. An apparatus comprises: a microfluidics system having an insertion slot for insertion of a droplet actuator; a bottom plate against which the droplet actuator would slide when inserting the droplet actuator into the insertion slot; and means for forcing a substrate in the droplet actuator parallel to the bottom plate, wherein warpage in the substrate is corrected.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: September 20, 2016
    Assignee: ADVANCED LIQUID LOGIC, INC.
    Inventors: William Craig Bauer, Ramakrishna Sista, Donovan E. Bort
  • Patent number: 9448158
    Abstract: Light collectors for fluorescence microscopy include slab light guides having a specimen volume such as a specimen well configured to retain a specimen. The specimen volume is bounded by a surface of the slab light guide that permits laterally propagating fluorescence to enter the slab light guide and propagate toward a detection or imaging system. Typically, the slab light guide has an elliptical perimeter and the sample volume is situated at a first focus of the elliptical perimeter. A reflector such as a conical reflector is situated at the second focus so as to direct the collected fluorescence to exit the slab light guide.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: September 20, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Jay R. Knutson, Christian A. Combs, Robert S. Balaban
  • Patent number: 9383490
    Abstract: A light beam is applied to a front surface of an optical depolarizer. The depolarizer rotates the polarization of light received on different surface positions by different amounts, so that the average incoming polarization is scrambled. The depolarizer has a first and second body that transmit first and second polarization components of the beam with mutually different speeds of light. Each body has two wedge shaped parts of variable thickness, corresponding wedge shaped parts in the two bodies providing light paths of substantially position independent lengths, but with variable rotation of polarization. The wedge shape parts of the front body form a concave input surface for the incoming beam. This prevents cross-over of light between the different wedge shaped parts.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: July 5, 2016
    Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
    Inventors: Borgert Kruizinga, Huibert Visser, Michiel David Nijkerk
  • Patent number: 9360426
    Abstract: Imaging a sample that includes phototransformable optical labels (“PTOLs”) with an optical system having a diffraction-limited resolution volume (DLRV), includes providing activation radiation to the PTOLs to activate a statistical subset of the PTOLs. A density of the PTOLs of the activated subset is less than an inverse of the DLRV. Excitation radiation is provided to the activated subset to excite activated PTOLs. Radiation emitted from the activated and excited PTOLs located at different focal planes of the optical system within the sample is detected with the optical system. The preceding steps are repeated one or more times, each time activating a different statistical subset of the plurality of PTOLs. Three-dimensional locations within the sample are determined, with a sub-diffraction-limited accuracy, of the activated and excited PTOLs based on the radiation emitted from the activated and excited PTOLs that is detected from the different focal planes of the optical system.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: June 7, 2016
    Assignee: Hestzig LLC
    Inventors: Robert Eric Betzig, Harald F. Hess
  • Patent number: 9329127
    Abstract: In a scanning system for the detection and discrimination of a plurality of targets in each of a plurality of samples, one or more multiband fluorescence detection channels each of which contains a single multiband emission filter and a single detector replaces multiple detection components in scanning heads of the prior art. In certain embodiments, a single multi-emitter light source is used as well, to illuminate each sample with excitation light at a variety of distinct wavelengths in succession.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: May 3, 2016
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Tom McCollum
  • Patent number: 9329130
    Abstract: The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological samples. More particularly, the invention relates to systems and methods for imaging, measuring, counting, analyzing, and monitoring microscopic particles such as cells and biological molecules in solution samples.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: May 3, 2016
    Assignee: Nexcelom Bioscience LLC
    Inventors: Leo L. Chan, Peter Li