By Light Patents (Class 356/317)
  • Patent number: 11490816
    Abstract: The present invention is directed to an apparatus (10) for reliable quantitative measurement of a fluorescent blood analyte in tissue (12) comprising: at least one light source (14), the light source (14) emitting excitation light at least at a first wavelength range between 350 nm and 450 nm to the tissue (12); a detection unit (16), the detection unit (16) measuring: a) a portion of the fluorescent light emitted by the fluorescent blood analyte excited at the first wavelength range; and b) a portion of the auto fluorescence emitted by the tissue (12); and/or c1) a portion of the remitted excitation light at the first wavelength range, and c2) a portion of the remitted light at a second wavelength range; and a control unit (18), the control unit (18) operating the light source (14) and detection unit (16). The present invention is further directed to a method for quantitative measurement of a fluorescent blood analyte in tissue (12).
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: November 8, 2022
    Assignee: FerroSens GmbH
    Inventors: Herbert Stepp, Georg Hennig, Christian Homann
  • Patent number: 11442017
    Abstract: An inspection apparatus is provided that comprises an optical target including a solid host material and a fluorescing material embedded in the solid host material. The solid host material has a predetermined phonon energy HOSTPE. The fluorescing material exhibits a select ground energy level and a target excitation (TE) energy level separated from the ground energy level by a first energy gap corresponding to a fluorescence emission wavelength of interest. The fluorescing material has a next lower lying (NLL) energy level relative to the TE energy level. The NLL energy level is spaced a second energy gap FMEG2 below the TE energy level, wherein a ratio of the FMEG2/HOSTPE is three or more.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: September 13, 2022
    Assignee: ILLUMINA, INC.
    Inventors: John Gerhardt Earney, Joseph Francis Pinto, M. Shane Bowen, Michael S. Graige, Arthur Pitera, Bala Murali K. Venkatesan, Dajun Yuan
  • Patent number: 11371079
    Abstract: Time-resolved nucleic acids include a long-lifetime FRET donor with an emission lifetime of at least one millisecond (such as a terbium complex), configured as a donor in a first FRET process, and at least one fluorescent dye with an emission lifetime of less than 100 nanoseconds configured as an acceptor in the FRET process. They can be configured as photonic wires, hybridization probes or beacons, and/or systems for computing logical operations.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: June 28, 2022
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Igor L. Medintz, Mario Ancona, W. Russ Algar, Melissa M. Massey
  • Patent number: 11359230
    Abstract: Time-resolved nucleic acids include a long-lifetime FRET donor with an emission lifetime of at least one millisecond (such as a terbium complex), configured as a donor in a first FRET process, and at least one fluorescent dye with an emission lifetime of less than 100 nanoseconds configured as an acceptor in the FRET process. They can be configured as photonic wires, hybridization probes or beacons, and/or systems for computing logical operations.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: June 14, 2022
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Igor L. Medintz, Mario Ancona, W. Russ Algar, Melissa M. Massey
  • Patent number: 11351760
    Abstract: Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: June 7, 2022
    Assignee: Washington University
    Inventors: Srikanth Singamaneni, Jingyi Luan, Jeremiah Morrissey, Evan Kharasch
  • Patent number: 11346720
    Abstract: In a spectrometry device, a control unit controls a light source so that input of excitation light to an internal space is maintained in a first period, and that the input of the excitation light to the internal space is stopped in a second period, and the analysis unit calculates the photoluminescence quantum yield of a long afterglow emission material on the basis of the number of absorbed photons of the long afterglow emission material obtained on the basis of excitation light spectral data in the first period and the number of light emission photons of the long afterglow emission material obtained on the basis of light emission spectral data in any of the first period, the second period, and a total period of the first period and the second period.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: May 31, 2022
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Kengo Suzuki, Shigeru Eura, Kazuya Iguchi
  • Patent number: 11333597
    Abstract: A system, an apparatus, and a method are provided for a modular flow cytometer with a compact size. In one embodiment, the modular flow cytometry system includes the following: a laser system for emitting laser beams; a flow cell assembly positioned to receive the laser beams at an interrogation region of a fluidics stream where fluoresced cells scatter the laser beams into fluorescent light; a fiber assembly positioned to collect the fluorescent light; and a compact light detection module including a first image array having a transparent block, a plurality of micro-mirrors in a row coupled to a first side of the transparent block, and a plurality of filters in a row coupled to a second side of the transparent block opposite the first side.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: May 17, 2022
    Assignee: Cytek Biosciences, Inc.
    Inventors: Ming Yan, Yung-Chieh Hsieh, David Vrane, Eric Chase, Wenbin Jiang
  • Patent number: 11325002
    Abstract: A method of operating a fitness tracking system includes receiving at least one first value and at least one second value for at least one foot action parameter from a sensor during a user workout. The method further includes determining whether the user has experienced a first type of fatigue and a second type of fatigue based on the at least one first value and the at least one second value, wherein the first type of fatigue is defined by different rules than the second type of fatigue. When it is determined that the user experienced the first type of fatigue, a first recommended action is provided to the user via a personal electronic device of the user. When it is determined that the user experienced the second type of fatigue, a second recommended action is provided to the user via the personal electronic device.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: May 10, 2022
    Assignee: Under Armour, Inc.
    Inventors: Jeff Knight, F. Grant Kovach, Paul Winsper, Michael Mazzoleni, Jeffrey Allen
  • Patent number: 11313784
    Abstract: Provided are a microparticle sorting device, and a method and a program for sorting microparticles capable of stabilizing sorting performance over a prolonged period of time. The microparticle sorting device includes an imaging element and a controller. The imaging element obtains an image of fluid and fluid droplets at a position where the fluid discharged from an orifice which generates a fluid stream is converted into the fluid droplets. The controller controls driving voltage of an oscillation element which gives oscillation to the orifice and/or controls a position of the imaging element based on a state of the fluid in the image and/or a state of a satellite fluid droplet. The satellite fluid droplet does not include microparticles and exists between the position, where the fluid is converted into the fluid droplets, and a fluid droplet, among fluid droplets including the microparticles, which is closest to the position where the fluid is converted into the fluid droplets.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: April 26, 2022
    Assignee: Sony Corporation
    Inventors: Fumitaka Otsuka, Yosuke Muraki
  • Patent number: 11280719
    Abstract: A particle sizing method which allows for counting and sizing of particles within a colloidal suspension flowing through a single-particle optical sizing sensor SPOS apparatus using pulse height detection and utilizing non-parallel and non-uniform illumination within the sensing region of the flow cell. The method involves utilizing a deconvolution process which requires the SPOS apparatus to be characterized during a calibration phase. Once the SPOS apparatus has been characterized, the process of deconvolution after a data collection run, recursively eliminates the expected statistical contribution to the pulse height distribution PHD histogram in all the lower channels from the highest channel height detected, and repeating this for all remaining channels in the PHD, removing the contributions from largest to smallest sizes.
    Type: Grant
    Filed: April 4, 2020
    Date of Patent: March 22, 2022
    Inventor: Paul Toumbas
  • Patent number: 11231365
    Abstract: Provided are an apparatus and a method for infrared imaging, more particularly, an apparatus and a method for infrared imaging, which receive infrared light, emitted from a target, and output the received infrared light as an image. An infrared imaging apparatus, in accordance with an exemplary embodiment, receives infrared light, emitted from a target, and outputs the received infrared light as an image. The infrared imaging apparatus includes: a reaction unit having physical properties changing in response to the received infrared light; a light source unit for generating measurement light irradiated toward the reaction unit; and an imaging unit for detecting the measurement light with the light quantity thereof changing depending on a change in the physical properties of the reaction unit and outputting the detected measurement light as an image.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: January 25, 2022
    Inventors: Bong Jun Choi, Ho Jin Hyun, Jong Hoo Park, Dae Kyeong Kang
  • Patent number: 11199488
    Abstract: The invention relates to a method for counting particles, particularly blood cells, in a sample, using a lensless optical imaging device. The sample is arranged between a light source and an image sensor. The sample is illuminated by a light source and an image is acquired by the image sensor, said image sensor being exposed to a light wave called an exposition wave. A digital propagation operator is applied to the acquired image so as to obtain a complex amplitude of the exposition wave according to a surface facing the image sensor. An image, called a reconstructed image, is formed from the modulus and/or the phase of said complex amplitude, on which image the particles to be counted appear in the form of regions of interest. The method then comprises a step of selecting the regions of interest corresponding to the particles to be counted.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 14, 2021
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, HORIBA ABX SAS
    Inventors: Pierre Blandin, Anais Ali-Cherif, Estelle Gremion, Sebastien Raimbault, Olivier Cioni, Aurelien Daynes
  • Patent number: 11196498
    Abstract: The present disclosure provides a high-precision time synchronization method. With the method, a traditional time synchronization protocol of a traditional IEEE 1588 network can be improved by introducing a periodic perturbation time between any two nodes in the time synchronization network, the perturbation time can be caused by changing the lengths of transmission paths or introducing clock phase perturbation due to different clock frequencies in the transistor and the receiver. With the method, the relevance of resulting errors of multiple synchronizations can be eliminated, and the perturbation can be compensated by means of statistical averaging, such that the synchronization error due to the low clock resolution of the synchronization node can be decreased. The method may realize the time synchronization at the precision of nanosecond, having significant advantages over the traditional time synchronization method based on IEEE 1588 protocol.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: December 7, 2021
    Assignee: TSINGHUA UNIVERSITY
    Inventors: Nan Hua, Ruijie Luo, Xiaoping Zheng
  • Patent number: 11187638
    Abstract: An apparatus for particle characterisation, comprising: a sample cell for holding a sample; a light source configured to illuminate the sample with an illuminating beam and a plurality of light detectors, each light detector configured to receive scattered light resulting from the interaction between the illuminating beam and the sample along a respective detector path, wherein each respective detector path is at substantially the same angle to the illuminating beam.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: November 30, 2021
    Assignee: Malvern Panalytical Limited
    Inventor: Jason Corbett
  • Patent number: 11154198
    Abstract: A system for fluorescence-based imaging of a target includes at least one excitation light source configured to emit a homogeneous field of excitation light and positioned to uniformly illuminate a target surface with the homogeneous field of excitation light during fluorescent imaging, a power source, and a portable housing configured to be held in a user's hand during imaging. The housing contains a lens, a filter, an image sensor, and a processor. The filter is configured to permit optical signals responsive to illumination of the target surface and having a wavelength corresponding to at least one of bacterial autofluorescence and tissue autofluorescence to pass through the filter to the image sensor. The at least one excitation light is adjacent to the housing so as to be positioned between the target surface and the image sensor during fluorescent imaging.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: October 26, 2021
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Ralph S. Dacosta, Brian C. Wilson, Kai Zhang
  • Patent number: 11092547
    Abstract: A method for observing a fluorescent sample, the sample comprising a fluorescent agent that emits fluorescence light, in a fluorescence spectral band, when it is illuminated by excitation light, in an excitation spectral band, the method comprising the following steps: a) placing the sample on a holder; b) illuminating the sample, with an excitation light source, in the excitation spectral band, the light emitted by the light source propagating along a propagation axis; c) detecting fluorescence light, in the fluorescence spectral band, with an image sensor; the method being such that the holder comprises a thin layer formed from a first material, of a first refractive index, the thin layer lying in a holder plane perpendicular to the propagation axis, the thin layer comprising a first photonic crystal and second photonic crystals configured to confine the excitation light and the fluorescence light in the thin layer.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: August 17, 2021
    Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Selimen Benahmed, Cedric Allier, Salim Boutami
  • Patent number: 11092532
    Abstract: The present invention includes method and device for label-free holographic screening and enumeration of tumor cells in bulk flow comprising: a laser source, a micro-objective, a pinhole device and a collimating lens, a mirror, a sample chamber with a sample flow inlet on a first side of the sample chamber and a sample flow outlet connected by a microchannel, and a detector, wherein the collimated laser beam passes through microchannel and interacts with cells in the sample to generate a respective hologram at the detector, wherein a processor calculates a numerical reconstruction from the respective hologram and generates a focused image of the numerous cells using the numerical reconstruction, wherein the numerous cells are enumerated by looking at a size, a maximum intensity and a mean intensity of the focused image.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: August 17, 2021
    Assignee: Texas Tech University System
    Inventors: Dhananjay Kumar Singh, Caroline C. Ahrens, Wei Li, Siva A. Vanapalli
  • Patent number: 11088352
    Abstract: A display substrate, a manufacturing method thereof, and a display device are provided, in the field of display technology. The display substrate includes a base substrate, and a thin-film transistor, a light-emitting device, an encapsulation structure, and a conductive film layer sequentially disposed on the base substrate in a direction away from the base substrate. Since the display substrate includes a conductive film layer on a side of the encapsulation structure away from the base substrate, when the protective film layer on the side of the conductive film layer away from the base substrate is peeled off, static electricity generated by the separation of the film layer can be released to the conductive film layer, avoiding electron transition to the active layer of the thin-film transistor in the display substrate to cause offset of the threshold voltage of the thin-film transistor. The display brightness uniformity of the display substrate can be ensured.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: August 10, 2021
    Assignee: BOE Technology Group Co., Ltd.
    Inventors: Wenqu Liu, Feng Zhang, Qi Yao, Zhijun Lv, Liwen Dong, Shizheng Zhang, Ning Dang, Xiaoxin Song, Zhao Cui
  • Patent number: 11048938
    Abstract: A method for recognizing individual plants of a selected type growing in a field, wherein the method comprises capturing color NIR image data of an entire field having plants of a selected type growing therein utilizing an automated plant counting system and calculating a ratio value between each pixel of the color image data and the corresponding pixel of the NIR image data utilizing a plant recognition algorithm executed via a data processing system of the plant counting system. The method additionally comprises generating, via execution of the plant recognition algorithm, a false color image of the field based on the calculated ratios for each pixel, and identifying, via execution of the plant recognition algorithm, all plants of the selected type in the false color image based on a plant distinguishing characteristic uniquely rendered for each individual plant of the selected type in the false color image.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: June 29, 2021
    Assignee: Monsanto Technology LLC
    Inventors: Christopher A. Hundley, James H. Crain
  • Patent number: 11047794
    Abstract: A system and method that improves and enhances the quality of step-scan Fourier Transform Infrared spectroscopy data. The system and method enables the removal of dark voltage with greater accuracy, provides access to previously unobtainable IR spectral information data which is amplified by the disclosed system and method. The system and method removes dark interferogram voltage from an interferogram of interest obtained during nanosecond or microsecond step-scan measurement. The system and method includes a programmable high gain setting to amplify both signal and noise into the analog-to-digital quantization range to allow signal averaging for obtaining additional bits of resolution. The system and method also accounts for and corrects intrinsic offset voltages introduced by the electronics of the disclosed system.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: June 29, 2021
    Assignee: The Board of Regents for Oklahoma State University
    Inventors: Chriswell G. Hutchens, Cheng Hao, Aihua Xie, Johnny Hendriks
  • Patent number: 11016026
    Abstract: In the scanning molecule counting method of measuring light intensity from a light detection region while moving the position of the light detection region of a confocal or multiphoton microscope in a sample solution containing light-emitting particles, generating time series light intensity data and detecting each of signals of the light-emitting particles individually in the data, wherein the light-emitting particles are formed by binding to a particle to be observed a light-emitting probe which emits light through binding to the particle to be observed and in which a stochastic transition between a non-light-emitting state and a light-emitting state occurs in the unbound state, the moving speed of the position of the light detection region is adjusted to make the time during which the unbound probe is encompassed by the moving light detection region longer than an average lifetime during which the probe is in the light-emitting state.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: May 25, 2021
    Assignee: OLYMPUS CORPORATION
    Inventors: Tetsuya Tanabe, Takuya Hanashi, Hidetaka Nakata
  • Patent number: 11002654
    Abstract: Measurement device and methods for the detection and/or analysis of fluid-borne particles. The measurement device comprises a means for producing a flow of fluid along a fluid flow path, a laser positioned for emitting a beam of laser light in a measurement volume of the fluid flow path; a lens set for collecting laser light scattered in the measurement volume by fluid-borne particles contained in the flow of fluid; a multipixel photo-detector positioned for detecting scattered laser light collected by the lens set. The lens set is configured for focusing the scattered light in a line being perpendicular to a flow direction (y) of the flow of fluid and at a focal distance of the lens set. The multipixel photodetector is positioned at a distance from the focal distance of the lens set and oriented with its longitudinal axis parallel to the line.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: May 11, 2021
    Assignee: PLAIR SA
    Inventor: Denis Kiselev
  • Patent number: 10996454
    Abstract: A microscope includes a movable stage supporting wells arranged in an array, a first imaging unit having a low-magnification objective lens, a second imaging unit having a high-magnification objective lens, a computer determining a representative position of a spheroid based on imaging data of the spheroid acquired by the first imaging unit, and a controller causing respective imaging units to sequentially acquire imaging data of the spheroid in each of the wells. The controller causes the first imaging unit to acquire imaging data for the spheroid in one of the wells, and then causes the stage to adjust the representative position to the optical axis of the high-magnification objective lens, and further causes the second imaging unit to acquire imaging data while causing the first imaging unit to acquire imaging data of the spheroid in another of the wells in synchronization with acquisition by the second imaging unit.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: May 4, 2021
    Assignee: OLYMPUS CORPORATION
    Inventor: Yoshihiro Shimada
  • Patent number: 10948703
    Abstract: Imaging systems and methods with scattering to reduce source auto-fluorescence and improve uniformity. In some embodiments, the system may include a plurality of trans-illumination light sources configured to irradiate an examination region with different colors of trans-illumination light, while a same diffuser is present in each optical path from the trans-illumination light sources to the examination region. The system also may comprise an excitation light source configured to irradiate the examination region with excitation light. The system may be configured to irradiate the examination region with each of the trans-illumination light sources and, optionally, with the excitation light source, without moving parts in any of the optical paths from the trans-illumination light sources. The system further may comprise an image detector configured to detect grayscale images of the examination region, and a processor configured to create a color trans-illumination image from grayscale images.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: March 16, 2021
    Assignee: Molecular Devices, LLC
    Inventor: Matthew Chan
  • Patent number: 10942122
    Abstract: A microscopy method includes illuminating an object with illumination light, recording a first color image of the illuminated object by a color image sensor suitable for recording colors of a first gamut, producing a second color image of the object, the second color image including pixels that each have assigned a color from a second gamut, depicting the second color image by a display apparatus suitable for rendering colors of the second gamut, wherein the producing the second color image includes determining the colors at the pixels of the second color image by applying a color transfer function to the colors of the corresponding pixels of the first color image, the color transfer function mapping input colors onto output colors, and the color transfer function mapping those input colors that belong to the first gamut but not to the second gamut onto output colors that belong to the second gamut.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: March 9, 2021
    Assignee: Carl Zeiss Meditec AG
    Inventors: Christoph Nieten, Enrico Geissler, Marco Wilzbach, Susanne Kohlhammer
  • Patent number: 10942108
    Abstract: To provide a technology that an output level difference is corrected with high accuracy in fine particle measurement that optically measures properties of fine particles. The present technology provides a fine particle measurement apparatus including a detector that detects light from fluorescent reference particles that emit fluorescence having a predetermined wavelength bandwidth, and an information processor that specifies a relationship between an applied voltage coefficient corresponding to a feature amount of a predetermined output pulse and a control signal of the detector on the basis of a feature amount of an output pulse detected by the detector and the control signal of the detector at the time of detecting the feature amount of the output pulse, the feature amount of the output pulse being dependent on the control signal of the detector, or the like.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: March 9, 2021
    Assignee: SONY CORPORATION
    Inventor: Katsutoshi Tahara
  • Patent number: 10925133
    Abstract: An electroluminescent LED device comprising a hole transport layer, an electron transport layer, an active emissive layer between the hole transport layer and the electron transport layer, and carbon dots forming the active emissive layer.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: February 16, 2021
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY
    Inventors: Weiyong Yu, Yu Zhang
  • Patent number: 10921241
    Abstract: An oblique incidence, prism-incident, silicon-based, immersion microchannel-based measurement device may include: a microchannel structure which has a support, a substrate which is formed on the support and made of a semiconductor or dielectric material, a cover part which has a prism structure and is installed on the support, and a microchannel which is formed in any one of an upper portion of the support and a lower end of the cover part; a sample injection part which forms an adsorption layer for a sample on a substrate by injecting a buffer solution containing the sample made of a biomaterial into the microchannel; a polarized light generation part which emits polarized incident light through an incident surface of the prism to the adsorption layer at an incident angle that satisfies a p-wave antireflection condition; and a polarized light detection part.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: February 16, 2021
    Assignee: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE
    Inventors: Hyun Mo Cho, Won Chegal, Yong Jai Cho
  • Patent number: 10914676
    Abstract: An observation apparatus in this embodiment includes a light source configured to irradiate an observation target with light, and a processing unit configured to generate an image based on Rayleigh scattered light derived from ?(3) included in light obtained from the observation target.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: February 9, 2021
    Assignee: NIKON CORPORATION
    Inventor: Naoki Fukutake
  • Patent number: 10888230
    Abstract: Methods and systems for detecting early stage dental caries and decays are provided. In particular, in an embodiment, laser-induced autofluorescence (AF) from multiple excitation wavelengths is obtained and analyzed. Endogenous fluorophores residing in the enamel naturally fluoresce when illuminated by wavelengths ranging from ultraviolet into the visible spectrum. The relative intensities of the AF emission changes between different excitation wavelengths when the enamel changes from healthy to demineralized. By taking a ratio of AF emission spectra integrals between different excitation wavelengths, a standard is created wherein changes in AF ratios within a tooth are quantified and serve as indicators of early stage enamel demineralization. The techniques described herein may be used in conjunction with a scanning fiber endoscope (SFE) to provide a reliable, safe and low-cost means for identifying dental caries or decays.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: January 12, 2021
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Eric J. Seibel, Leonard Y. Nelson
  • Patent number: 10883917
    Abstract: A method for imaging 1-D nanomaterials is provided. The method includes: providing a 1-D nanomaterials sample; immersing the 1-D nanomaterials sample in a liquid; illuminating the 1-D nanomaterials sample by a first incident light and a second incident light to cause resonance Rayleigh scattering, wherein the first incident light and the second incident light are not parallel to each other; and acquiring a resonance Rayleigh scattering image of the 1-D nanomaterials sample with a microscope.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: January 5, 2021
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Wen-Yun Wu, Dong-Qi Li, Jin Zhang, Kai-Li Jiang, Shou-Shan Fan
  • Patent number: 10866191
    Abstract: An atomization unit has a tube-shaped furnace, and heats and atomizes a sample injected into the furnace. A light source unit emits light having a wavelength to be measured toward the atomization unit such that light passes through the furnace. An optical system transmits the light having the wavelength to be measured, of light passing through the furnace. A detection unit detects the light transmitted by the optical system. A light transmission plate is provided at a position in an optical path of the light passing through the furnace toward the detection unit, to obliquely cross an optical axis of the light. An image capturing unit is arranged outside the optical path, and captures an image inside the furnace by receiving light reflected by the light transmission plate, of the light passing through the furnace.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: December 15, 2020
    Assignee: SHIMADZU CORPORATION
    Inventors: Atsuhiko Otaguro, Osuke Kobayashi
  • Patent number: 10854662
    Abstract: Imaging systems and methods for imaging using the same color or monochromatic image sensor, wherein imaging can be switched between at least two imaging modes, for example between a visible imaging mode and an IR imaging mode, without moving any system component from a given position in an optical path between an imaged object and the image sensor. In an example, a system includes an image sensor, a tunable spectral filter and a multi-bandpass filter, the tunable spectral filter and the multi-bandpass filter arranged in a common optical path between an object and the image sensor, and a controller configured and operable to position the tunable spectral filter in a plurality of operation states related to a plurality of imaging modes.
    Type: Grant
    Filed: November 18, 2017
    Date of Patent: December 1, 2020
    Assignee: UNISPECTRAL LTD.
    Inventors: Ariel Raz, Viacheslav Krylov, Eliahu Chaim Ashkenazi, Peleg Levin, Efrat Immer
  • Patent number: 10845535
    Abstract: Systems and methods are provided for processing an optical signal. An example system may include a source disposed on a substrate and capable of emitting the optical signal. A first waveguide is formed in the substrate to receive the optical signal. A first coupler is disposed on the substrate to receive a reflected portion of the optical signal. A second waveguide is formed in the substrate to receive the reflected portion from the first coupler. A second coupler is formed in the substrate to mix the optical signal and the reflected portion to form a mixed signal. Photodetectors are formed in the substrate to convert the mixed signal to an electrical signal. A processor is electrically coupled to the substrate and programmed to convert the electrical signal from a time domain to a frequency domain to determine a phase difference between the optical signal and the reflected portion.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: November 24, 2020
    Assignee: Hewlett Packard Enterprise Development LP
    Inventors: Amit S. Sharma, John Paul Strachan, Marco Fiorentino
  • Patent number: 10830696
    Abstract: A solid-state device for photo detection, in general, of terahertz radiation is disclosed. One aspect is a detector device comprising a body having a photoconductive material, a first antenna element connected to a first portion of the body, and a second antenna element connected to a second portion of the body. The first antenna element and the second antenna element are arranged to induce an electric field in the body in response to an incident signal. Further, the device has a waveguide arranged to couple light into the photoconductive material via a coupling interface between the waveguide and the body, where the coupling interface faces away from the first portion and the second portion of the body and is closer to the first portion than to the second portion.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: November 10, 2020
    Assignees: IMEC vzw, Stichting IMEC Nederland
    Inventors: Peter Offermans, Joris Van Campenhout
  • Patent number: 10821446
    Abstract: The present technology provides for a fluorescent detector that is configured to detect light emitted for a probe characteristic of a polynucleotide. The polynucleotide is undergoing amplification in a microfluidic channel with which the detector is in optical communication. The detector is configured to detect minute quantities of polynucleotide, such as would be contained in a microfluidic volume. The detector can also be multiplexed to permit multiple concurrent measurements on multiple polynucleotides concurrently.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: November 3, 2020
    Assignee: HANDYLAB, INC.
    Inventors: Kalyan Handique, Sundaresh N. Brahmasandra
  • Patent number: 10768112
    Abstract: An optical detection method and an optical detection device quickly and accurately detects a micro target substance, such as an antigen, with high sensitivity by using an enhanced electric field. The optical detection device includes: one or more light irradiation units; a detection plate having a laminate structure; a prism in close optical contact to a back surface side of the detection plate and having multiple light incident surfaces with different incidence angles; and a light detection unit which is placed on the front surface side of the detection plate and which detects an optical signal from a sample. Light from the light irradiation unit enters the light incident surfaces of the prism at a fixed angle with respect to the front surface of the detection plate, and the light passing through the prism is irradiated from the back surface side of the detection plate under a total reflection condition.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: September 8, 2020
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Masato Yasuura, Makoto Fujimaki
  • Patent number: 10761011
    Abstract: Any one or both of an optical system with a structured lighting pattern and a structured detecting system having a plurality of regions with different optical characteristics are used. In addition, optical signals from an object to be observed through one or a small number of pixel detectors are detected while changing relative positions between the object to be observed and any one of the optical system and the detecting system, time series signal information of the optical signals are obtained, and an image associated with an object to be observed from the time series signal information is reconstructed.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: September 1, 2020
    Assignees: The University of Tokyo, Osaka University
    Inventors: Sadao Ota, Ryoichi Horisaki, Kazuki Hashimoto
  • Patent number: 10712270
    Abstract: A digital holographic microscope in which two digital holographic microscopes for detecting a fluorescence image and a phase image, respectively, are combined to be able to three-dimensionally measure a fluorescence image and a phase image at the same time, and perform measurement at a high SN ratio in all the polarization states including random light polarization. A first holographic optical system that, by using laser light, acquires a phase three-dimensional image due to interference light generated by superimposing object light which passes through a sample stage and reference light which does not pass through the sample stage onto each other. A second holographic optical system that, by using fluorescent excitation light, acquires a fluorescence three-dimensional image due to a fluorescence signal light, wherein phase measurement by the first holographic optical system and fluorescence measurement by the second holographic optical system are performed at the same time.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: July 14, 2020
    Assignee: National University Corporation Kobe University
    Inventor: Osamu Matoba
  • Patent number: 10678805
    Abstract: Techniques and mechanisms are disclosed that enable a data collection system to adaptively control collection of data from one or more external data sources. At a high level, adaptively controlling collection of data from external data sources may include collecting performance information related to one or more data collection nodes and, in response to analyzing the collected performance information, adapting rates at which the data collection nodes send data collection requests to external data sources. Data collection performance information generally may include, but is not limited to, network traffic data, error messages generated by external data sources and/or data collection nodes, computing device performance information, and any other types of information related to a data collection node's ability to collect data from external data sources.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: June 9, 2020
    Assignee: Splunk Inc.
    Inventors: Ken Chen, Gang Tao, Lai Qiang Ding, Junqing Hao, Ting Wang, Elias Haddad, Dritan Bitincka
  • Patent number: 10639680
    Abstract: A system for the detection of foreign object debris material on a surface includes an ultraviolet light source configured to direct ultraviolet light across a surface. The surface is an outer surface of a composite part being formed by a composite layup machine. The system includes an ultraviolet light camera configured to scan the surface and output a first signal proportional to reflected ultraviolet light reflected by at least one of the surface and a first type of foreign object debris material. The reflected ultraviolet light is responsive to the ultraviolet light from the ultraviolet light source. The system also includes a controller coupled to the ultraviolet light source and to the ultraviolet light camera. The controller is configured to compare the first signal from the ultraviolet light camera with a first threshold to detect presence of the first type of foreign object debris material.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: May 5, 2020
    Assignee: THE BOEING COMPANY
    Inventors: Morteza Safai, Jeffrey G. Thompson
  • Patent number: 10605715
    Abstract: The present invention is to provide a flow cytometer comprising: flow cell; a liquid feeding unit for feeding a liquid different from a sample liquid containing sample particles to the flow cell; a sample liquid feeding unit for feeding the sample liquid to the flow cell after the liquid is sent to the flow cell; and a detector for detecting the sample particles flowing through the flow cell.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: March 31, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Shohei Matsumoto, Tomoya Hayashi
  • Patent number: 10527550
    Abstract: A method for investigating biological cells or cell cultures in a microplate reader receives at least one microplate with wells containing biological cells or cell cultures by a receiving device; positions the wells with respect to measuring devices of the microplate reader and detects integral measurement signals by at least one of the measuring devices. The biological cells or cell cultures in the specific wells of the microplate(s) are transilluminated by an illumination source of the microplate reader and imaged by an imaging camera. Each of the detected integral signals is compared with the image of the biological cells or cell cultures in the corresponding wells of the microplate(s) by a processor and is related to the imaged number, adherence, confluence or morphology of these biological cells or cell cultures.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: January 7, 2020
    Assignee: TECAN TRADING AG
    Inventors: Harald Gebetsroither, Andreas Gfrorer, Juha Koota
  • Patent number: 10516132
    Abstract: The present invention provides an inverted QD-LED and a manufacturing method thereof. The manufacturing method of an inverted QD-LED according to the present invention adopts a hydrothermal synthesis process to form a monocrystalline TiO2 nanorod array film for serving as an electron transport layer, wherein a plurality of monocrystalline TiO2 nanorods contained in the monocrystalline TiO2 nanorod array film are arranged in an array so as not to readily get aggregated thereby overcoming the deficiencies of inhomogeneous film formation resulting from aggregation of TiO2 nanometer particles, lowered electron transport efficiency, and low light extraction efficiency, and thus ensuring high-efficiency electron transport rate of the electron transport layer, increasing scattering of light to heighten light extraction efficiency, and improve luminous efficiency and stability of a device.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: December 24, 2019
    Assignee: SHENZHEN CHINA STAR OPTOELECTRONICS SEMICONDUCTOR DISPLAY TECHNOLOGY CO., LTD.
    Inventor: Yadan Xiao
  • Patent number: 10509167
    Abstract: Systems and methods are provided for processing an optical signal. An example system may include a source disposed on a substrate and capable of emitting the optical signal. A first waveguide is formed in the substrate to receive the optical signal. A first coupler is disposed on the substrate to receive a reflected portion of the optical signal. A second waveguide is formed in the substrate to receive the reflected portion from the first coupler. A second coupler is formed in the substrate to mix the optical signal and the reflected portion to form a mixed signal. Photodetectors are formed in the substrate to convert the mixed signal to an electrical signal. A processor is electrically coupled to the substrate and programmed to convert the electrical signal from a time domain to a frequency domain to determine a phase difference between the optical signal and the reflected portion.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: December 17, 2019
    Assignee: Hewlett Packard Enterprise Development LP
    Inventors: Amit S. Sharma, John Paul Strachan, Marco Fiorentino
  • Patent number: 10495719
    Abstract: Methods and systems for determining the direction to at least one source contributing to a wave field. A wave field partial wave expansion (PWE) model is comprised of wave field partial wave functions (PWFs) and unknown PWE coefficients corresponding to the wave field PWFs. A source PWE model is comprised of source PWFs and source PWE coefficients corresponding to the source PWFs, the source PWE coefficients being expressed in terms of source PWFs of the directional coordinates of the source. A processor, using: the output signals from at least one sensor outputting signals consistent with Nyquist criteria representative of the wave field; a library of PWFs to determine at least one of the unknown PWE coefficients; and the source PWE model, determines directional coordinates of the source (wherein the number of floating point operations are reduced) and outputs the directional coordinates to a reporter configured for reporting information to humans.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: December 3, 2019
    Inventor: Charles Alphonse Uzes
  • Patent number: 10481001
    Abstract: An optical spectrum measuring apparatus includes: a CCD (Charge Coupled Device) detector including a plurality of light-receiving devices that are two-dimensionally arranged; an optical system configured to split incident light into rays and irradiate the CCD detector with the rays; and a restriction unit configured to restrict one or more rows and/or one or more columns out of the rows and columns of the plurality of light-receiving devices from being irradiated with light from the optical system.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: November 19, 2019
    Assignee: Otsuka Electronics Co., Ltd.
    Inventor: Goro Maeda
  • Patent number: 10463256
    Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: November 5, 2019
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Stephen Chad Kanick, Brian William Pogue, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy, III, Venkataramanan Krishnaswamy
  • Patent number: 10393587
    Abstract: Methods for laser induced ablation spectroscopy are disclosed. A sample site position sensor, and stage position motors can move the stage in three independent spatial coordinate directions, and a stage position control circuit is used to move an analysis sample site to selected coordinate positions for laser ablation. Light emitted from a plasma plume produced with laser ablation can be gathered into a lightguide fiber bundle that is subdivided into branches. One branch can convey a first portion of the light to a broadband spectrometer operable to analyze a relatively wide spectral segment, and a different branch can convey a second portion of the light to a high dispersion spectrometer operable to measure minor concentrations and/or trace elements. Emissions from a plasma plume can be simultaneously analyzed in various ways using a plurality of spectrometers having distinct and/or complementary capabilities.
    Type: Grant
    Filed: July 3, 2016
    Date of Patent: August 27, 2019
    Assignee: Applied Spectra, Inc.
    Inventors: Jong Hyun Yoo, Randolph S. Tribe, Chunyi Liu
  • Patent number: 10386338
    Abstract: The present invention relates to a piezoelectric mechanical system (PEMS) microcantilever sensor that both detects the presence of viral RNA in an aqueous solution, such as a blood sample. The method provides for the formation of the sensor by attaching RNA, DNA, or an antibody to the microcantilever sensor surface via a hydrazone or an oxime chemical bond. The method provides for the detection of viral RNA viruses and viral DNA viruses upon the chemical binding/bonding of single-stranded viral nucleic acid to the microcantilever sensor surface. The method provides for the detection of DNA cancer mutations or variants that have been identified in a cancer cell upon the chemical binding/bonding of single-stranded DNA to the microcantilever sensor surface.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: August 20, 2019
    Inventor: Cynthia Rena Wright