Monochromatic (e.g., Laser) Patents (Class 356/318)
  • Patent number: 10295465
    Abstract: The invention relates to an in vitro diagnostic method for quantification of a clinical chemistry analyte from a clinical sample wherein the clinical chemistry analyte undergoes a chemical reaction or reactions with a reagent or reagents in one or several steps, or in a reaction sequence, or catalyzes a chemical reaction, or reactions, or a reaction in a reaction sequence of a reagent or reagents, in one or several steps, in a reaction system. The reaction or reactions or reaction sequence result in a change of a measurable property of a compound or compounds of said reaction or reactions or reaction sequence.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: May 21, 2019
    Assignee: Arctic Diagnostics Oy
    Inventors: Erkki Soini, Aloksi Soini, Juhani Soini, Niko Meltola
  • Patent number: 10281406
    Abstract: A method and apparatus for analyzing one or more elements of targeted moving food surfaces uses laser-induced breakdown spectroscopy to detect the presence, absence, or amount of an element on a heterogeneous surface of an object, including surfaces of food products. A laser is used to quantify an element concentration without destroying the object. The method can be configured to include an automated on-line system comprising a closed-loop feedback control system operable to select a predetermined concentration.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: May 7, 2019
    Inventors: Richard E. Russo, Jong Hyun Yoo, Chunyi Liu
  • Patent number: 10284797
    Abstract: An image generating system according to an aspect of the present disclosure includes an image obtaining device, an image generating circuit, and an image processing circuit. The image obtaining device includes an illuminating system that irradiates an object included in a module in which the object and an imaging element are integrated together, with light sequentially from a plurality of different radiation directions. The image obtaining device obtains a plurality of images corresponding to the plurality of different radiation directions. The image generating circuit generates a high-resolution image of the object having a higher resolution than each of the plurality of images by combining the plurality of images together. The image processing circuit detects noise resulting from a foreign object located farther from an imaging surface of the imaging element than the object and removes the noise.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: May 7, 2019
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Yasuhiko Adachi, Yoshikuni Sato, Hideto Motomura
  • Patent number: 10270998
    Abstract: An imaging apparatus includes: a light source that emits a light pulse onto an object, and a light detector that detects a reflected light pulse returning from the object. The light detector detects a first part of the reflected light pulse in a first period, and detects a second part of the reflected light pulse in a second period that starts after the first period. The first period includes at least a part of a rising period, the rising period being a period from start to end of increase of intensity of the reflected light pulse. The second period includes a part of a falling period, starts after start of the falling period and does not include the start of the falling period, the falling period being a period from start to end of decrease of the intensity.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: April 23, 2019
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Tatsuya Nakamura, Takamasa Ando, Teruhiro Shiono
  • Patent number: 10232473
    Abstract: A system and method for performing laser induced breakdown spectroscopy during laser ablation of a coating, such as a TBC coating, deposited on a surface of a component, particularly to enable obtained spectrometry signals of the ablated coating to be used to monitor and control the laser ablation removal process in real-time. The system includes a laser energy source and a scan head interconnected with the laser energy source to receive a laser beam therefrom and then direct the laser beam onto the surface of the coated component. Collection optics collect radiation emitted from a laser-induced plasma generated by the laser beam at the surface of the coated component. The system is further equipped to spectrally analyze the radiation and generate a feedback signal for control and optimization of one or more operational parameters of the laser energy source in real-time.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: March 19, 2019
    Assignee: General Electric Company
    Inventors: Ying Zhou, Hongqiang Chen, Matthew Vaughan Schulmerich, Jason Christopher Gritti
  • Patent number: 10201299
    Abstract: The present invention relates to a chemo-optical sensor unit for transcutaneous measurement of a concentration of a gas, comprising: at least one gas-permeable sensing layer adapted to be irradiated with a predetermined radiation; and at least a first gas-permeable layer adjacent to one side of the at least one sensing layer, adapted to pass gas whose concentration is to be measured through the gas-permeable layer towards the sensing layer; at least one volatile acid and/or base binding layer in the gas-pathway from the skin to the sensing layer; adapted to pass gas whose concentration is to be measured through the volatile acid and/or base binding layer towards the sensing layer; wherein said chemo-optical sensor unit is adapted to operate with a contact medium between the chemo-optical sensor unit and the skin and wherein the chemo-optical sensor unit is adapted to measure an optical response of the at least one sensing layer, whose optical response depends on the concentration of the gas.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: February 12, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Josephus Arnoldus Henricus Maria Kahlman, Nicolaas Lambert, Hans Willem Van Kesteren
  • Patent number: 10197445
    Abstract: According to an example embodiment, a detector assembly for use in analysis of elemental composition of a sample by using optical emission spectroscopy is provided, the detector assembly including a rotatable element that is rotatable about an axis and that has attached thereto a laser source for generating laser pulses for invoking optical emission on a surface of the sample, the laser source arranged to generate laser pulses focused at a predefined distance from said axis at a predefined distance from a front end of the detector assembly, and a detector element for capturing optical emission invoked by said laser pulses.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: February 5, 2019
    Assignee: Hitachi High-Tech Analytical Science Limited
    Inventor: Jukka Hassi
  • Patent number: 10180425
    Abstract: A DNA ligand capable of structural changes upon binding to a target is used as a molecular switch with a SPFS (surface plasmon field-enhanced fluorescence spectroscopy) biosensor to realize one-step SPFS biosensing with rapid turnaround time. The SPFS biosensor has a thin metal film on a prism; when a light of a certain wavelength irradiates on the prism at a certain angle, a strong electrical field is generated at the surface of the metal film. The DNA is immobilized on the metal film surface with its free terminal modified with a fluorescent marker. Without the target, the DNA is folded and the fluorescent marker is located in the region of metal quenching near the metal surface. Upon binding to the target, the DNA is extended and the fluorescent marker is located in the region of enhanced electric field near the metal surface and emits a strong fluorescent signal.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: January 15, 2019
    Assignee: KONICA MINOLTA LABORATORY U.S.A., INC.
    Inventor: Noriaki Yamamoto
  • Patent number: 10101210
    Abstract: A portable analyzer determines composition of a sample and includes excitation means for invoking an optical emission from a surface of the sample, detector means for observing a selectable wavelength in said optical emission and for recording a detection signal that is descriptive of at least one characteristic of said optical emission at a selected wavelength, analysis means for determination of elemental composition of the sample on basis of one or more detection signals; and control means for carrying out a spectral analysis by operating the excitation means to generate the optical emission for recording respective detection signals at predefined wavelengths, operating the detector means to record the respective one or more detection signals at said one or more predefined wavelengths, and operating the analysis means to determine elemental composition of the sample on basis of said recorded detection signals.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: October 16, 2018
    Assignee: Hitachi High-Tech Analytical Science Limited
    Inventor: Tuomas Pylkkanen
  • Patent number: 10073034
    Abstract: The present invention relates to a method for measuring the lifetime of an excited state in a sample, in particular a fluorescence lifetime, and to an apparatus for carrying out such a method. First, an excitation pulse is generated and a sample region is illuminated with the excitation pulse. Then, a first digital data sequence is generated which is representative of the power-time profile of the excitation pulse, and a first switching instant is determined from the first digital data sequence. Moreover, the detection light emanating from the sample region is detected by a detector, and a second digital data sequence is generated which is representative of the power-time profile of the detection light, and a second switching instant is determined from the second digital data sequence. Finally, the time difference between the first and second switching instants is calculated.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: September 11, 2018
    Assignee: Leica Microsystems CMS GmbH
    Inventor: Bernd Widzgowski
  • Patent number: 10060777
    Abstract: An “air-data probe” system measures at least one component of freestream velocity by tracking the motion of a laser-induced breakdown (“LIB”) spark created in a freestream flow. Neutral density filters are positioned or deployed so that the brightness of the initial LIB spark doesn't over saturate the LIB sensor system. This allows for more consistent tracking of the LIB spark throughout the duration of the LIB spark, including the later stages where the LIB spark is not nearly as bright as the initial LIB spark, thereby allowing all or substantially all of the light generated by the LIB spark to reach the sensors. This provides for enhanced visibility and more accurate detection of the LIB spark over time and as air density changes.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: August 28, 2018
    Inventors: Alan B Cain, Stanislav Gordeyev, R. Mark Rennie
  • Patent number: 10052024
    Abstract: Provided is a biometric device which may include a light source unit configured to irradiate an organism with inspection light, a light-collection unit arranged facing a region on a surface of the organism and configured to spatially-integrally collect output light emitted from the region in accordance with the inspection light, and a light-reception unit configured to receive the collected output light.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: August 21, 2018
    Assignee: Sony Corporation
    Inventor: Hideo Sato
  • Patent number: 10025081
    Abstract: An objective and an illumination unit for selectable generation of an orthoscopic beam path proceeding through the objective for pointlike scanning illumination, and of a conoscopic beam path proceeding through the objective for evanescent illumination of an object are disclosed. The illumination unit has a light source for generating illuminating rays along an illuminating beam path; a displacement unit for deflecting the illuminating beam path; a scanning eyepiece, placed after the displacement unit for focusing the illuminating rays into an image plane of the scanning eyepiece; and a mirror surface arranged in the image plane of the scanning eyepiece, having a transparent region for generating the orthoscopic beam path and having an at least partly reflective region facing toward the scanning eyepiece for generating the conoscopic beam path from the illuminating beam path, the image plane is located in a plane conjugated with the exit pupil.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: July 17, 2018
    Assignee: Leica Microsystems CMS GmbH
    Inventors: Peter Euteneuer, Christian Schumann
  • Patent number: 10001440
    Abstract: An observation apparatus and an observation method are provided. The observation apparatus includes a light source that emits illumination light used to observe a specimen to which a fluorescent substance that specifically binds to or is expressed in a stimulus target has been supplied, an illumination optical system that radiates the illumination light emitted from the light source 11 onto the specimen, a deflecting device that changes an area of the specimen to be irradiated with the illumination light, a wavelength selecting section that selects the wavelength of illumination light to be radiated onto the specimen, an observation optical system that collects light from the specimen, a detector that detects the light collected by the observation optical system, an image processing section that generates an image from the light detected by the detector, and a control section that controls these components.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: June 19, 2018
    Assignee: OLYMPUS CORPORATION
    Inventor: Susumu Honda
  • Patent number: 9998692
    Abstract: A process is provided for providing high contrast motion picture imagery. The camera system includes a physical architecture that enables multiple sensors to simultaneously acquire a visual scene without parallax or dissimilar exposures. The system architecture enables current off the shelf components to be used to develop the architecture or a specific sensor array to be developed. The architecture includes optical components that split an incident light ray into multiple beams of varying intensity. Each respective split light ray is then attenuated further with neutral density filters for the wavelengths to be observed before the light ray impacts the respective pixel sights. A process has been developed to use the camera system architecture to stochastically recombine the acquired energy and estimate what the original energy was before attenuation. The process involves the development of an optimal non recursive weighting function that can be used and constructed into a lookup table.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 12, 2018
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: David J. Griffiths
  • Patent number: 9983120
    Abstract: An imaging section that detects the amount of light separated by a wavelength tunable interference filter to acquire a spectroscopic image (imaging device and light amount acquisition section) detects the amount of light successively separated for three wavelengths to acquire spectroscopic images for producing a combined image. A display controller causes a display section to display a combined image based on the spectroscopic images for producing the combined image. A specified position detection section identifies based on user's operation a specified position where a colorimetry result is to be outputted. The imaging section detects the amount of light successively separated for a plurality of wavelengths by the wavelength tunable interference filter to acquire spectroscopic images for colorimetry corresponding to the plurality of wavelengths. A colorimetry section measures the color in the specified position by using the amount of light obtained from each of the spectroscopic images for colorimetry.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: May 29, 2018
    Assignee: SEIKO EPSON CORPORATION
    Inventor: Tetsuo Tatsuda
  • Patent number: 9958395
    Abstract: This invention discloses an improved laser induced breakdown spectroscopy (LIBS) apparatus and method for the detection of mineral and metal contamination in liquid samples. The mineral and metal contaminant is first collected by filtering the liquid sample with a membrane filter. The membrane filter with the mineral and metal contaminant is then measured by a LIBS apparatus. The LIBS apparatus is based on a high repetition rate pulsed laser. The laser produces a train of laser pulses at a high repetition rate in the kHz (or even higher) range. When the laser beam hits the surface of the membrane filter, it generates several thousands of micro-plasma emissions per second. Synchronized miniature CCD array optical spectrometer modules collect the LIBS signal from these micro-plasma emissions. By adjusting the integration time of the spectrometer to cover a plurality of periods of the laser pulse train, the spectrometer integrates the LIBS signal produced by this plurality of laser pulses.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: May 1, 2018
    Assignee: BWT Property, Inc.
    Inventors: Xin Jack Zhou, Sean Xiaolu Wang, Qun Li
  • Patent number: 9952159
    Abstract: This invention discloses a laser induced breakdown spectroscopy (LIBS) apparatus based on high repetition rate pulsed laser. The laser produces a train of laser pulses at a high repetition rate in the kHz (or even higher) range. When the laser beam hits the biological sample, it generates several thousands of micro-plasmas per second. Synchronized miniature CCD array optical spectrometer modules collect the LIBS signal from these micro-plasmas. By adjusting the integration time of the spectrometer to cover a plurality of periods of the laser pulse train, the spectrometer integrates the LIBS signal produced by this plurality of laser pulses. Hence the intensity of the obtained LIBS spectrum can be greatly improved to increase the signal-to-noise ratio (SNR) and lower the level of detection (LOD).
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: April 24, 2018
    Assignee: BWT Property, Inc.
    Inventors: Sean Xiaolu Wang, Qun Li
  • Patent number: 9891173
    Abstract: A method for detecting an element in a sample using molecular emission by double pulse laser-induced breakdown spectroscopy is provided. The method includes observing emissions from molecules including the element to be detected. The method is particularly useful for detecting halogens, whose elemental emissions are difficult to detect, rare earth elements and boron.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: February 13, 2018
    Assignee: LASER DISTANCE SPECTROMETRY LTD.
    Inventors: Michael Gaft, Lev Nagli
  • Patent number: 9839361
    Abstract: Imaging, testing and/or analysis of subjects are facilitated with a capillary-access approach. According to an example embodiment, a capillary is implanted into a specimen and adapted to accept an optical probe to facilitate optical access into the specimen. In some applications, the capillary is implanted for use over time, with one or more different probes being inserted into the capillary at different times, while the capillary is implanted. Certain applications involve capillary implantation over weeks, months or longer. Other applications are directed to the passage of fluid to and/or from a sample via the capillary. Still other applications are directed to the passage of electrical information between the sample and an external arrangement, via an implanted capillary.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: December 12, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark Jacob Schnitzer, Juergen Claus Jung
  • Patent number: 9829692
    Abstract: An optical observation unit (1) has an illumination apparatus (43) for illuminating an observation object (3). The illumination apparatus (43, 143) has a light source (45) emitting illumination light with a first color temperature, and a spectral filter (49) that can be inserted in the illumination beam path. The spectral filter (49) converts the illumination light with the first color temperature into illumination light with a second color temperature. The illumination apparatus further has an attenuator (51) that can be inserted in the illumination beam path in place of the spectral filter (49) and has a transmission characteristic that leads to an intensity reduction of the illumination light with the first color temperature that corresponds to the intensity reduction of the illumination light with the second color temperature by way of the spectral filter (49).
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: November 28, 2017
    Assignee: CARL ZEISS MEDITEC AG
    Inventors: Peter Reimer, Thomas Kratzer, Stefan Ernsperger, Bruno Stich
  • Patent number: 9823129
    Abstract: A printer includes a spectroscope and a carriage moving unit. The spectroscope includes a wavelength-selective interference filter on which light from a measurement target is incident, and the carriage moving unit moves the spectroscope in an X direction with respect to the measurement target. If the measurement target is a color patch, the spectroscope performs spectrometry by changing a wavelength of light passing through the wavelength-selective interference filter in a first period during which the spectroscope is moved in the X direction, and passes light of an initial wavelength through the wavelength-selective interference filter at a start of measurement and at an end of measurement in the first period. A first output value that is a measured value from the spectrometry at the start of measurement is compared with a second output value that is a measured value from the spectrometry at the end of measurement.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: November 21, 2017
    Assignee: Seiko Epson Corporation
    Inventor: Ryohei Kuri
  • Patent number: 9797835
    Abstract: An in-situ on-line detection device and detection method for a long-distance metallurgical liquid metal component. The detection device comprises a front-end high-temperature resistant probe, a middle-end optical sensing device and a back-end control platform, wherein the head of the front-end high-temperature resistant probe is placed in a liquid metal, the tail thereof is coaxially connected to the middle-end optical sensing device, and an optical window is arranged in the connection position; and the middle-end optical sensing device is connected to the back-end control platform through a signal line. The detection device and detection method can provide a timely and valid message for quality control and a melting end, so that the detection time is greatly shortened, the detection distance can he adjusted extensively, the measurement result is accurate, and it can be achieved to measure components that are difficult to measure such as carbon, sulfur, phosphorous, etc.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: October 24, 2017
    Assignee: SHENYANG INSTITUTE OF AUTOMATION OF THE CHINESE ACADEMY OF SCIENCES
    Inventors: Lanxiang Sun, Haibin Yu, Yong Xin, Lifeng Qi, Yang Li, Zhibo Cong
  • Patent number: 9797776
    Abstract: This invention discloses a laser induced breakdown spectroscopy (LIBS) apparatus based on a high repetition rate pulsed laser. The laser produces a train of laser pulses at a high repetition rate in the kHz or even higher range. When the laser beam hits the sample, it generates several thousands of micro-plasma emissions per second. Synchronized miniature CCD array optical spectrometer modules collect the LIBS signal from these micro-plasma emissions. By adjusting the integration time of the spectrometer to cover a plurality of periods of the laser pulse train, the spectrometer integrates the LIBS signal produced by this plurality of laser pulses. Hence the intensity of the obtained LIBS spectrum can be greatly improved to increase the signal-to-noise ratio (SNR) and lower the limit of detection (LOD).
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: October 24, 2017
    Assignee: BWT Property, Inc.
    Inventors: Sean Xiaolu Wang, Qun Li
  • Patent number: 9766223
    Abstract: This invention provides new methods and apparatus for rapidly analyzing a single bioparticle or a plurality of bioparticles to assess their condition. The invention is enabled by an optical microcavity comprising reflective structures to confine light and bioparticles in the same space. Under resonance conditions, an electromagnetic standing wave is established in the microcavity to interact with the bioparticle. Means are provided to bring a bioparticle into the microcavity and to detect changes in the resonance condition with and without the bioparticle in the microcavity. Information about the bioparticle is obtained using the benefits of light interactions as fast, non-contacting, and non-destructive.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: September 19, 2017
    Inventor: Paul L. Gourley
  • Patent number: 9759661
    Abstract: In a device for the optical imaging of a sample, having at least one light source for excitation light in order to excite a fluorescent dye in a sample, which is held by a sample holder, for spontaneous emission of fluorescent light over a limited period of time in a spatial region having increased resolution, and for de-excitation light in order to de-excite the fluorescent dye again except for a residual zone that is reduced in size relative to the spatial region, wherein light from the sample having wavelengths other than those of the excitation light and of the de-excitation light is assignable to the spontaneous emission of fluorescent light from the residual zone of the spatial region (STED, GSD, etc.), the de-excitation light (3) is arranged to be transmitted in two parallel planes which are separated by a gap (2).
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: September 12, 2017
    Assignee: Hans-Ulrich Dodt
    Inventor: Hans-Ulrich Dodt
  • Patent number: 9738864
    Abstract: A device (10) for detecting the presence of at least one microorganism in the contents (101, 201) of a container (100, 200) comprising a wall with a translucent zone, said detection device (10) comprising: a) at least one light source (11), such as a light-emitting diode (LED), capable of illuminating the contents of the container (100, 200) by emitting an excitation light beam through the translucent zone of the container (100, 200); b) at least one detection means (12, 13, 14, 15), such as a photodiode, for detecting at least one reaction light beam emitted in response to the illumination of the contents (101, 201) of the container (100, 200); said at least one light source (11) and said at least one detection means (12, 13, 14, 15) being equipped with at least one connection means (105, 205), to connect said at least one light source (11) and said at least one detection means (12, 13, 14, 15) to the wall of the container (100, 200), in the translucent zone, said at least one detection means (12, 13, 14
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: August 22, 2017
    Assignee: Biomerieux
    Inventors: Bruno Colin, Corinne De La Foata, Jacques Dachaud, Fabienne Made
  • Patent number: 9739715
    Abstract: A method of setting a laser-light intensity value includes: emitting laser light, the laser light being excitation light, a fluorescent-dyed biological sample being irradiated with the excitation light and emitting light; detecting fluorescence emitted by the biological sample, and outputting a signal corresponding to a brightness value; prestoring relation information, the relation information including the plurality of laser-light intensity values, and information on at least one possible correlation between a phototoxicity degree and the brightness value in relation to each of the laser-light intensity values, the phototoxicity to the biological sample resulting from the laser light; generating a fluorescence image having the brightness value based on the output signal; calculating a brightness value representative of a ROI area based on the generated fluorescence image; and referring to the relation information, and determining a laser-light intensity value satisfying tolerance of the phototoxicity based
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: August 22, 2017
    Assignee: Sony Corporation
    Inventors: Shinji Watanabe, Kazuki Aisaka
  • Patent number: 9719933
    Abstract: A method of quantifying at least one property of interest of an oil sands ore sample is provided using a laser-induced breakdown spectroscopy (LIBS) method. The LIBS method may be applied to oil sands ore being conveyed prior to a slurry process to measure oil sand composition and provide information which may predict extraction characteristics. The LIBS method may be applied to oil sands core samples in a laboratory setting to reduce the cost and analysis time associated with conventional laboratory measurement techniques.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: August 1, 2017
    Assignees: SYNCRUDE CANADA LTD, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Richard Paproski, Aïssa Harhira, David Duford, Josette El Haddad, Darcy Daugela, Alain Blouin, Mohamad Sabsabi
  • Patent number: 9696260
    Abstract: An installation for spectroscopic measurement includes a focusing system (2) for focusing a laser beam (3) on a sample (4) for analysis and a system (17) for collecting and spectroscopically analyzing light rays emitted by the plasma (15), this system (17) including, in particular, an optical fiber (18) for collecting light. The installation also includes a motor-driven system (23) for moving the optical fiber (18), an optical imaging system (25) for imaging the plasma in the form of an image, and a processor and control unit (24). The unit (24) is capable of analyzing the image formed by the optical imaging system in order to select a zone of interest and controlling the motor-driven system (23) in order to place the optical fiber in a position enabling it to collect light coming from the selected zone of interest in the plasma.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: July 4, 2017
    Assignees: UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Vincent Motto-Ros, Jin Yu
  • Patent number: 9658103
    Abstract: A measuring apparatus, comprising at least a first light source and a second light source for transmitting light; at least one light receiver for receiving light at least of a first received wavelength and a second received wavelength; at least one dispersing element for bending and/or refracting light; wherein the light transmitted by the light sources strikes the dispersing element and is so turned by the dispersing element that it strikes the light receiver. The first light source is arranged at a first angle relative to the dispersing element and the second light source at a second angle relative to the dispersing element, wherein the second angle differs from the first angle. The first angle is so embodied that the wavelength of the light turned by the dispersing element corresponds to the first received wavelength, and wherein the second angle is so embodied that the wavelength of the light turned by the dispersing element corresponds to the second received wavelength.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: May 23, 2017
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventor: Ralf Bernhard
  • Patent number: 9651478
    Abstract: The analyzer according to the embodiment comprises an irradiation optical part that irradiates a mixture inside reaction tubes with light from a light source. Moreover, a detection optical part detects light transmitted through the mixture. Moreover, the irradiation optical part comprises a first optical element in which the light source is disposed at the front focal position and that concentrates light from the light source. Moreover, a second optical element guides light transmitted through the first optical element to the reaction tubes. In addition, an incident numerical aperture adjustment member is provided at the rear side of the first optical element and adjusts the numerical aperture when light from the light source is incident on the reaction tubes.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: May 16, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Shoichi Kanayama, Tomoyuki Tada, Naotada Okada
  • Patent number: 9625391
    Abstract: (EN) The invention relates to a special LIBS measurement tube focusing unit, referred to simply as LIBS measurement tube, for vertically dipping into a material to be analyzed, which material is moved in a horizontal flow, characterized in that the measurement tube extends vertically and is internally hollow and open at least at the bottom end, such that a bottom edge is formed at the bottom end, the measurement tube has an inlet for coupling in a laser beam and an outlet for coupling out an emission spectrum at the upper end, the measurement tube is constructed in such a way that, in the measurement tube, the laser beam is focused at the material to be analyzed, specifically bulk material, in particular raw, intermediate, and end products from the processing of potash, magnesium, rock salt, or evaporated salt, but without additional scattering and deflection occurring, such that a plasma of the material to be analyzed is produced within the measurement tube by the laser radiation and the emission spectrum of
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: April 18, 2017
    Assignee: K+S Aktiengesellschaft
    Inventors: Udo-Walter Lisner, Torsten Rest, Jessica Waechter, Joachim Makowe, Volker Moerkens, Christoph Dominic Gehlen
  • Patent number: 9606068
    Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: March 28, 2017
    Assignee: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
    Inventors: Annette Grot, Ravi Saxena, Paul Lundquist
  • Patent number: 9606065
    Abstract: Disclosed herein is a quantitative analysis method for measuring a target element in a specimen using laser-induced plasma spectrum. More particularly, the present invention relates to a method for analyzing a composition ratio of a target element by calculating peak intensities when peaks overlap each other in a spectrum, and a method for selecting a peak of a wavelength at which the highest precision and reproducibility are secured through linearity of a correlation plot of the peak intensities and a value by dividing a standard deviation value of calibration curve data (peak intensity ratios) by a slope when an internal standard method is used for quantitative analysis of a target element.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: March 28, 2017
    Assignee: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sungho Jeong, Jeonghwan In, Chan Kyu Kim, Seokhee Lee
  • Patent number: 9584730
    Abstract: The disclosed apparatus, systems, and methods provide for a displacement sensor with a multi-position image sensor. The displacement sensor includes an optical lens. The displacement sensor includes an image sensor configured to view an object through the lens along a plane of focus that is not parallel to an image plane of the image sensor. The displacement sensor includes a laser for illuminating the object by the displacement sensor, wherein the laser is: spaced from the lens at a fixed distance, and configured to project a line of light along the plane of focus of the image sensor. The displacement sensor comprises a first configuration wherein the image sensor is at a first location along an image plane with a first field of view along the plane of focus, and a second configuration at a second location with a different field of view.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: February 28, 2017
    Assignee: COGNEX CORPORATION
    Inventors: George Costigan, Laurens Nunnink, Aaron Wallack, Roger Sumner
  • Patent number: 9568423
    Abstract: A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: February 14, 2017
    Assignee: ACEA Biosciences, Inc.
    Inventors: Nan Li, Jian Wu, Ye Chen, Tianxing Wang, Xiaobo Wang
  • Patent number: 9568430
    Abstract: An analysis system includes a moveable focusing lens, a laser (typically an eye safe laser) having an output directed at the focusing lens, and a spectrometer outputting intensity data from a sample. A controller system is responsive to the spectrometer and is configured to energize the laser, process the output of the spectrometer, and adjust the position of the focusing lens relative to the sample until the spectrometer output indicates a maximum or near maximum intensity resulting from a laser output focused to a spot on the sample.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: February 14, 2017
    Assignee: SciAps, Inc.
    Inventor: David Day
  • Patent number: 9551650
    Abstract: An integrated optofluidic system for trapping and transporting particles for analysis is provided comprising a planar substrate; a microfluidic channel; and a waveguide integrated with the channel. A microsphere particle in the integrated optofluidic system can act as a cavity, allowing light to circulate many thousands of times around the circumference of the microsphere. Optical trapping and transport is used for nanoscale positioning to excite the microsphere resonances. Sensitive measurements on molecules can be accomplished by monitoring changes in whispering gallery modes (WGMs) that propagate around the circumference of the microsphere. By using a broadband or supercontinuum light source, a microsphere can be trapped and many WGM resonances can be excited through the visible and near-infrared wavelengths simultaneously. After the resonances are measured using the waveguide transmission, the microsphere can be freed by decreasing the optical power and the process repeated with a different microsphere.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: January 24, 2017
    Assignee: Cornell University
    Inventors: Arthur Nitkowski, Michal Lipson
  • Patent number: 9513473
    Abstract: Fluorescence microscopy systems with polychroic mirror changers are described. In one aspect, a polychroic mirror changer includes a polychroic-mirror array. The array includes a plate with a planar surface and a number of holes formed in the plate. The array also includes polychroic mirrors attached to the planar surface of the plate such that each polychroic mirror covers one of the holes and the reflective surface of each polychroic mirror is adjacent to and aligned with the planar surface of the plate. Each polychroic mirror is partially exposed through a corresponding hole to reflect a different subset of excitation channels of a beam of excitation light input to the changer. The polychroic-mirror array can be mounted in the changer so that when a different subset of excitation channels is selected to illuminate a specimen, the plate is moved within a single plane of motion.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: December 6, 2016
    Assignee: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventors: Jeremy R. Cooper, Justin Kyle Curts
  • Patent number: 9506869
    Abstract: A novel device, method and systems disclosed managing the thermal challenges of LIBS laser components and a spectrometer in a handheld structure as well the use of simplified light signal collection which includes a bare fiber optic to collect the emitted light in close proximity to (or in contact with) the test material. In one example embodiment of the handheld LIBS device, a burst pulse frequency is 4 kHz is used resulting in a time between pulses of about 250 ?s which is a factor of 10 above that of other devices in the prior art. In a related embodiment, an active Q-switched laser module is used along with a compact spectrometer module using a transmission grating to improve LIBS measurement while substantially reducing the size of the handheld analyzer.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: November 29, 2016
    Assignee: TSI, Incorporated
    Inventors: Frederick Quant, Kenneth R. Farmer, Phillip V. Tan, Christopher B. Stipe, Steven G. Buckley, Erik Stockinger, Daniel Jensen
  • Patent number: 9506808
    Abstract: An apparatus is provided for performing photothermal measurements on a object. The apparatus, which may be provided as a handpiece, houses optical components including a laser, an infrared detector, a dichroic beamsplitter, and focusing and beam directing optics for the delivery of a laser beam to, and the collection of photothermal radiation from, a measured object. Some of the optical components may be provided on an optical bench that is directly attached to a thermally conductive tip portion for the passive heat sinking of internal optical components. The apparatus may further include a sampling optical element and a photodetector for the detection of luminescence, and a camera for obtaining an image of the object during a diagnostic procedure. The apparatus may be employed for the scanning of a tooth to determine an oral health status of the tooth.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: November 29, 2016
    Assignee: QUANTUM DENTAL TECHNOLOGIES, INC.
    Inventors: Jin-Seok Jeon, Andreas Mandelis, Stephen Abrams, Anna Matvienko, Koneswaran Sivagurunathan, Josh Silvertown, Adam Hellen
  • Patent number: 9494598
    Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: November 15, 2016
    Assignees: Singulex, Inc., The Regents of the University of California
    Inventors: Philippe Goix, Robert Puskas, John Todd, Richard Livingston, Douglas Held, Allan H. B. Wu
  • Patent number: 9482624
    Abstract: The present invention relates to an inspection apparatus, the inspection apparatus including a projection unit configured to project a plurality of lights, each having a different focal length relative to a surface of an inspection object, and an inspection unit configured to inspect a surface of an inspection object using the light reflected from the inspection object, wherein the projection unit is provided with a plurality of lenses configured to project the lights, and curvature of each lens is different, and the focal length is different due to the difference of the curvature, whereby the curve on a surface of the inspection object can be reliably measured.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: November 1, 2016
    Assignee: Sunmoon University Industry-University Cooperation
    Inventor: Kuk Won Ko
  • Patent number: 9476829
    Abstract: A system for classifying moving materials in real time, the system including a laser pulse generator operative to generate at least first and second laser pulses which impinge on the same impingement location on the moving materials, the first and second laser pulses being separated in time by up to 10 microseconds; and an absorption detector operative to sense an absorption spectrum at the impingement location over a detection time duration of up to 20 nanoseconds following the second laser pulse.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: October 25, 2016
    Assignee: LASER DISTANCE SPECTROMETRY LTD.
    Inventors: Lev Nagli, Michael Gaft
  • Patent number: 9397466
    Abstract: An optical amplification system is disclosed which includes a seed source providing a seed beam, and a chirally coupled core fiber amplifier optically coupled to the seed beam and configured to convert the coupled seed beam into an amplifier output beam, wherein the polarization of the seed beam is controllably launched into the chirally coupled core fiber in order to reduce nonlinearities in the amplifier output beam. Peak output powers in excess of 500 kW can be realized for short-pulsed single-mode beams having mode field diameters greater than 30 ?m.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: July 19, 2016
    Assignee: nLIGHT, Inc.
    Inventors: Timothy S. McComb, Roger L. Farrow
  • Patent number: 9315855
    Abstract: Described systems and methods allow the detection of and determination of a concentration of a target analyte such as a biological cell, a virus, a polypeptide, a toxin, a pesticide, a drug, a drug residue, or a DNA strand, in a fluid sample. A variable stimulus, such as an oscillating magnetic field or a light beam of oscillating intensity, is applied to the sample, inducing variations in a position or shape of a constituent of the sample, or variations in a fluorescence of the sample. Such variations produce measurable variations in electric and/or optical properties of a sensor, variations which allow the determination of the concentration of the target analyte.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: April 19, 2016
    Assignee: Centrul International De Biodinamica
    Inventors: Eugen Gheorghiu, Mihai Sorin David, Cristina Polonschii, Dumitru Bratu
  • Patent number: 9310304
    Abstract: Provided are methods for multiplex polymerase chain reaction (PCR) amplification of short tandem repeat (STR) loci that can be used to rapidly generate a highly specific STR profile from target nucleic acids. The resulting STR profiles are useful for human identification purposes in law enforcement, homeland security, military, intelligence, and paternity testing applications.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: April 12, 2016
    Assignee: NetBio, Inc.
    Inventors: James W. Schumm, Richard F. Selden, Eugene Tan
  • Patent number: 9304085
    Abstract: A method of setting a laser-light intensity value includes: emitting laser light, the laser light being excitation light, a fluorescent-dyed biological sample being irradiated with the excitation light and emitting light; detecting fluorescence emitted by the biological sample, and outputting a signal corresponding to a brightness value; prestoring relation information, the relation information including the plurality of laser-light intensity values, and information on at least one possible correlation between a phototoxicity degree and the brightness value in relation to each of the laser-light intensity values, the phototoxicity to the biological sample resulting from the laser light; generating a fluorescence image having the brightness value based on the output signal; calculating a brightness value representative of a ROI area based on the generated fluorescence image; and referring to the relation information, and determining a laser-light intensity value satisfying tolerance of the phototoxicity based
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: April 5, 2016
    Assignee: Sony Corporation
    Inventors: Shinji Watanabe, Kazuki Aisaka
  • Patent number: 9296068
    Abstract: An object of the present invention is to provide a laser irradiation method and a laser irradiation apparatus for irradiating an irradiation surface with a linear beam having more homogeneous intensity by blocking a low-intensity part of the linear beam without forming the fringes due to the diffraction on the irradiation surface. In the laser irradiation, a laser beam emitted from a laser oscillator 101 passes through a slit 102 so as to block a low-intensity part of the laser beam, the traveling direction of the laser beam is bent by a mirror 103, and an image formed at the slit is projected to an irradiation surface 106 by a convex cylindrical lens 104.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: March 29, 2016
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Koichiro Tanaka, Yoshiaki Yamamoto