Monochromatic (e.g., Laser) Patents (Class 356/318)
  • Patent number: 10684225
    Abstract: For multi-dimensional high-resolution imaging a structure marked with fluorescence markers, fluorescence enabling light is focused to illuminate a measurement area in a sample. A partial area of the measurement area is subjected to fluorescence inhibiting light. The partial area omits a center of the measurement area in that an intensity distribution of the fluorescence inhibiting light comprises a line-shaped intensity minimum. A minimal extension of the intensity minimum in a direction through the center area is by a factor k?2 smaller than a diameter of the measurement area in said direction. Without spatial resolution, fluorescence light emitted out of the measurement area is measured for a plurality of consecutive angle positions of the intensity minimum about the center, while the measurement area, for each angle position, is subjected to the fluorescence enabling light. A value of the measured fluorescence light is assigned to the position of the center.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: June 16, 2020
    Assignee: LASER-LABORATORIUM GOETTINGEN E.V
    Inventors: Alexander Egner, Claudia Geisler, Jennifer-Rose Krueger
  • Patent number: 10684205
    Abstract: A method and an apparatus to improve the precision and reproducibility of particle size analysis by laser diffraction is presented. Powder particles are typically prepared for laser diffraction testing using an ultra-sound bath which will disperse particle agglomerates and allow a precise measurement. However, the precision and reproducibility of agglomerate dispersion is affected by ultra-sound probe wear, corrosion and age. Differences in sonication performance can be compensated by voltage adjustments to the ultra-sound probe, leading to substantial improvements in the precision and reproducibility of particle size determination.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: June 16, 2020
    Assignee: Hovione Technology Ltd
    Inventor: Leandro Martins
  • Patent number: 10677733
    Abstract: Devices and methods are disclosed that allow for analysis with simplified sample preparation. Of particular relevance is the analysis of wire samples (e.g., weld wires) using laser induced breakdown spectroscopy (LIBS) or optical emission spectrometry (OES). Representative devices can isolate a sample, such as in a sealed, inert environment in an analytical instrument. These devices may include first and second sample end attachments connected to a body, which has a connecting portion that may be configured for alignment with the face of the instrument. The body may also include a rotatable cap, and the sample end attachments may be joined to this cap (e.g., at opposite ends thereof) to allow adjustment of the angular position of the sample, relative to the connecting portion, which in use may be affixed to the instrument.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: June 9, 2020
    Assignee: Thermo Scientific Portable Analytical Instruments Inc.
    Inventors: Andrew T. Leoni, Michael Bush, Wayne Minter, Neil P. Hagerty, Artur Malinouski
  • Patent number: 10677741
    Abstract: Systems, methods, and devices of the various embodiments may enable simultaneous preparation of a substrate for adhesive bonding and detection of minute contaminants on the substrate. Various embodiments may enable detection of contaminants on a surface of a substrate while the surface of the substrate is being prepared for adhesive bonding by laser ablation. Various embodiments may provide an integrated laser treatment and measurement system.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: June 9, 2020
    Assignee: United States of America as Represented by the Administrator of NASA
    Inventors: John W. Connell, Frank L. Palmieri, William T. Yost, John W. Hopkins, Rodolfo I Ledesma
  • Patent number: 10670510
    Abstract: Refractive index of biological specimens is a source of intrinsic contrast that can be explored without any concerns of photobleaching or harmful effects caused by extra contrast agents. This feature also contains rich information that can be related to the metabolism of cells at the cellular and subcellular levels. The present invention relates to systems and methods that can provide, without any moving parts, the 3-D refractive index map of continuously flowing biological samples in a micro-fluidic channel, for example.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: June 2, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Yongjin Sung, Niyom Lue, Zahid Yaqoob, Ramachandra Dasari, Peter T. C. So
  • Patent number: 10663404
    Abstract: The present invention relates to a highly portable, highly flexible standard of distance chemical detector such as can be used, for example, for standoff detection of explosives. Aspects of the invention include techniques for portability compactness and ways to diminish influence of fluorescence on Raman spectroscopy. Additional features can include a compact imaging spectrometer, a wirelessly connected smart device for user interface, and an auto-focus/range finder.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: May 26, 2020
    Assignee: Alakai Defense Systems, Inc.
    Inventors: Robert Dean Babnick, Darius Vunck, Robert Douglas Waterbury, Timothy Molner, Ed Dottery
  • Patent number: 10641712
    Abstract: A system for sorting reusable raw-material pieces, where the chemical composition of the raw-material pieces is analyzed by laser-induced breakdown spectroscopy (LIBS), where the raw-material pieces in a first step are subjected to a plurality of first laser pulses in order to remove surface coatings and/or contaminants from the raw-material pieces, and in a second step, one or more further laser pulses from the same laser are used to generate a plasma.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: May 5, 2020
    Assignee: Clean-Lasersysteme Gmbh
    Inventors: Edwin Buchter, Winfried Barkhausen, Hans-Bernd Pillkahn
  • Patent number: 10620118
    Abstract: The present invention relates to methods for identifying optical materials, and more specifically to methods employed to identify glass and other optical materials used in medical devices. The method includes the steps of (1) selecting refractive index liquids matching a given optical sample; (2) determining the matching points for the refractive index liquids; and (3) calculating the refractive indices and selecting best fit optical materials. The invention also relates to a system for identifying optical materials. The system is under the control and operation of a computing device which documents, displays and stores all the data.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: April 14, 2020
    Assignee: STERIS Instrument Management Services, Inc.
    Inventor: Jurgen Zobel
  • Patent number: 10613096
    Abstract: A measurement system includes a system for causing relative motion between a sample and an irradiation spot. The sample includes fluorescent markers having respective wavelengths. A gating system provides a gating signal based at least in part on resultant light substantially at an irradiation wavelength. A detection system detects fluorescent light from the irradiated markers and provides detection signals representing the fluorescent light detected concurrently with a gate-open signal. In some examples, the detection system detects fluorescent light at multiple wavelengths and provides respective detection signals. A spectral discriminator arranged optically between the sample and the detection system receives the fluorescent light from the sample and provides respective fluorescent light at the wavelengths to the detection system. A flow cytometer can spectrally disperse resultant fluorescent light and measure the wavelengths separately.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: April 7, 2020
    Assignee: CAPTL LLC
    Inventors: Masanobu Yamamoto, J. Paul Robinson
  • Patent number: 10583468
    Abstract: A laser coating removal system includes a detector and a controller. The detector detects wavelengths associated with radiative emission of elements in laser-induced plasma generated by the laser coating removal. The controller generates concentration data based on the wavelengths, the concentration data indicating concentration of the elements in the laser-induced plasma, and notifies a user of the laser coating removal system in response to concentration of one of the elements in the laser-induced plasma being greater than or equal to a predetermined threshold.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: March 10, 2020
    Assignee: Surclean, Inc.
    Inventors: Kevin Hagedorn, Donald Sprentall
  • Patent number: 10585028
    Abstract: An optical analysis apparatus, including: a sample delivery system from which a liquid sample may be delivered in operation; a flow cell defining a channel through which, in operation, the delivered liquid sample may flow at a controllable rate, the channel including an optical analysis region; an illumination source focused on a portion of the optical analysis region that, in operation, illuminates a single particle at a time in a stream of the sample wider than the single particle; a detector that, in operation, detects light resulting from the illumination of the sample and outputting a signal representative of the detected light; and an analysis system receiving the representative signal.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: March 10, 2020
    Assignee: Charted Scientific, Inc.
    Inventor: Edward Calvin
  • Patent number: 10571598
    Abstract: A security inspection apparatus and a security inspection method are disclosed. In one aspect, an example apparatus includes a CT inspection device and a Raman spectrum inspection device, the CT inspection device includes: a CT scanner scanning an object to be inspected to generate a CT image, an image recognizing device recognizing the CT image to check whether or not the object has a suspected hazardous article, and an object marking device making a predetermined marker on the object which has the suspected hazardous article. The Raman spectrum inspection device includes: a Raman spectrum measuring device extracting a Raman spectrum of the suspected hazardous article in the object, a Raman spectrum comparing device comparing the Raman spectrum of the suspected hazardous article with Raman spectra of known compositions to determine a composition of the suspected hazardous article, and an object marker recognizing device recognizing the predetermined marker on the object.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: February 25, 2020
    Assignee: Nuctech Company Limited
    Inventors: Jianhong Zhang, Nei Yang, Hongqiu Wang, Yumin Yi, Hu Tang, Guohua Wei
  • Patent number: 10537225
    Abstract: A marking method includes: a step of irradiating, with first light (narrow band light) from an endoscope, an observation target site not suitable for spray of a coloring agent in a subject; a step of picking up an image of, through the endoscope, second light (reflected light of the narrow band light) generated at the observation target site through irradiation of the observation target site with the narrow band light; a step of displaying an image in which a site suspected to be a tumor is highlighted by generating the image based on the second light received through the endoscope; and a step of providing a tissue denatured portion around the site suspected to be a tumor by using an energy radiation device while the displayed image is observed.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: January 21, 2020
    Assignee: OLYMPUS CORPORATION
    Inventors: Yasuyuki Futatsugi, Shigeru Imai, Shin Hirashima
  • Patent number: 10527496
    Abstract: According to an example embodiment, a detector assembly for use in analysis of elemental composition of a sample by using optical emission spectroscopy is provided, the detector assembly comprising a rotatable element that is rotatable about an axis and that has attached thereto a laser source for generating laser pulses for invoking optical emission on a surface of the sample, which laser source is arranged to generate laser pulses focused at a predefined distance from said axis at a predefined distance from a front end of the detector assembly, and an optical receiver for capturing optical emission invoked by said laser pulses.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: January 7, 2020
    Assignee: Hitachi High-Tech Analytical Science Limited
    Inventor: Jukka Hassi
  • Patent number: 10520372
    Abstract: An optical manufacturing process sensing and status indication system is taught that is able to utilize optical emissions from a manufacturing process to infer the state of the process. In one case, it is able to use these optical emissions to distinguish thermal phenomena on two timescales and to perform feature extraction and classification so that nominal process conditions may be uniquely distinguished from off-nominal process conditions at a given instant in time or over a sequential series of instants in time occurring over the duration of the manufacturing process. In other case, it is able to utilize these optical emissions to derive corresponding spectra and identify features within those spectra so that nominal process conditions may be uniquely distinguished from off-nominal process conditions at a given instant in time or over a sequential series of instants in time occurring over the duration of the manufacturing process.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: December 31, 2019
    Assignee: SIGMA LABS, INC.
    Inventors: Vivek R. Dave, Mark J. Cola, R. Bruce Madigan, Martin S. Piltch, Alberto Castro
  • Patent number: 10514338
    Abstract: A target within a sample can be characterized using an energy source configured to transform a metal in the sample into a plasma and an optical spectroscopic detector configured to detect electromagnetic radiation emitted by the plasma to provide an optical-spectrum signal. A processor can determine presence of the metal in the sample using the optical-spectrum signal. The target can include a microbe or biological toxin. A recognition construct comprising a metal and a scaffold can be applied to the sample. The scaffold can bind to the target. Energy can be applied to transform at least some of the sample into a plasma. Electromagnetic radiation emitted by the plasma can be detected to provide an optical-spectrum signal of the sample. A preparation subsystem can add the recognition construct to the sample and a washing subsystem can wash unbound recognition construct out of the sample.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: December 24, 2019
    Assignee: Purdue Research Foundation
    Inventors: Joseph Paul Robinson, Bartlomiej P. Rajwa, Valery P. Patsekin, Euiwon Bae
  • Patent number: 10481074
    Abstract: Systems in a flow cytometer having an interrogation zone and illumination impinging the interrogation zone include: a lens subsystem including a collimating element that collimates light from the interrogation zone, a light dispersion element that disperses collimated light into a light spectrum, and a focusing lens that focuses the light spectrum onto an array of adjacent detection points; a detector array, including semiconductor detector devices, that collectively detects a full spectral range of input light signals, in which each detector device detects a subset spectral range of the full spectral range of light signals; and a user interface that enables a user to create a set of virtual detector channels by grouping detectors in the detector array, such that each virtual detector channel corresponds to a detector group and has a virtual detector channel range including the sum of subset spectral ranges of the detectors in the corresponding detector group.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: November 19, 2019
    Assignee: Becton, Dickinson and Company
    Inventor: Collin A. Rich
  • Patent number: 10422693
    Abstract: Described herein are optical sensing devices for photonic integrated circuits (PICs). A PIC may comprise a plurality of waveguides formed in a silicon on insulator (SOI) substrate, and a plurality of heterogeneous lasers, each laser formed from a silicon material of the SOI substrate and to emit an output wavelength comprising an infrared wavelength. Each of these lasers may comprise a resonant cavity included in one of the plurality of waveguides, and a gain material comprising a non-silicon material and adiabatically coupled to the respective waveguide. A light directing element may direct outputs of the plurality of heterogeneous lasers from the PIC towards an object, and one or more detectors may detect light from the plurality of heterogeneous lasers reflected from or transmitted through the object.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: September 24, 2019
    Assignee: Aurrion, Inc.
    Inventors: Gregory Alan Fish, Jonathan Edgar Roth, Brandon Buckley
  • Patent number: 10401280
    Abstract: In one example, testing cells extend along a length of a slot. Each testing cell includes a microfluidic channel extending from the slot, a pump to move fluid from the slot into the channel, a discharge nozzle through which fluid exits the channel, a fluid discharger to discharge fluid from the channel through the nozzle and a photosensor. A light guide is provided to receive light from an external light source and is to serially transmit the light to the microfluidic channel of each of the plurality of testing cells.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: September 3, 2019
    Assignee: Hewett-Packard Development Company, L.P.
    Inventor: Timothy L. Weber
  • Patent number: 10295465
    Abstract: The invention relates to an in vitro diagnostic method for quantification of a clinical chemistry analyte from a clinical sample wherein the clinical chemistry analyte undergoes a chemical reaction or reactions with a reagent or reagents in one or several steps, or in a reaction sequence, or catalyzes a chemical reaction, or reactions, or a reaction in a reaction sequence of a reagent or reagents, in one or several steps, in a reaction system. The reaction or reactions or reaction sequence result in a change of a measurable property of a compound or compounds of said reaction or reactions or reaction sequence.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: May 21, 2019
    Assignee: Arctic Diagnostics Oy
    Inventors: Erkki Soini, Aloksi Soini, Juhani Soini, Niko Meltola
  • Patent number: 10281406
    Abstract: A method and apparatus for analyzing one or more elements of targeted moving food surfaces uses laser-induced breakdown spectroscopy to detect the presence, absence, or amount of an element on a heterogeneous surface of an object, including surfaces of food products. A laser is used to quantify an element concentration without destroying the object. The method can be configured to include an automated on-line system comprising a closed-loop feedback control system operable to select a predetermined concentration.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: May 7, 2019
    Inventors: Richard E. Russo, Jong Hyun Yoo, Chunyi Liu
  • Patent number: 10284797
    Abstract: An image generating system according to an aspect of the present disclosure includes an image obtaining device, an image generating circuit, and an image processing circuit. The image obtaining device includes an illuminating system that irradiates an object included in a module in which the object and an imaging element are integrated together, with light sequentially from a plurality of different radiation directions. The image obtaining device obtains a plurality of images corresponding to the plurality of different radiation directions. The image generating circuit generates a high-resolution image of the object having a higher resolution than each of the plurality of images by combining the plurality of images together. The image processing circuit detects noise resulting from a foreign object located farther from an imaging surface of the imaging element than the object and removes the noise.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: May 7, 2019
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Yasuhiko Adachi, Yoshikuni Sato, Hideto Motomura
  • Patent number: 10270998
    Abstract: An imaging apparatus includes: a light source that emits a light pulse onto an object, and a light detector that detects a reflected light pulse returning from the object. The light detector detects a first part of the reflected light pulse in a first period, and detects a second part of the reflected light pulse in a second period that starts after the first period. The first period includes at least a part of a rising period, the rising period being a period from start to end of increase of intensity of the reflected light pulse. The second period includes a part of a falling period, starts after start of the falling period and does not include the start of the falling period, the falling period being a period from start to end of decrease of the intensity.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: April 23, 2019
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Tatsuya Nakamura, Takamasa Ando, Teruhiro Shiono
  • Patent number: 10232473
    Abstract: A system and method for performing laser induced breakdown spectroscopy during laser ablation of a coating, such as a TBC coating, deposited on a surface of a component, particularly to enable obtained spectrometry signals of the ablated coating to be used to monitor and control the laser ablation removal process in real-time. The system includes a laser energy source and a scan head interconnected with the laser energy source to receive a laser beam therefrom and then direct the laser beam onto the surface of the coated component. Collection optics collect radiation emitted from a laser-induced plasma generated by the laser beam at the surface of the coated component. The system is further equipped to spectrally analyze the radiation and generate a feedback signal for control and optimization of one or more operational parameters of the laser energy source in real-time.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: March 19, 2019
    Assignee: General Electric Company
    Inventors: Ying Zhou, Hongqiang Chen, Matthew Vaughan Schulmerich, Jason Christopher Gritti
  • Patent number: 10201299
    Abstract: The present invention relates to a chemo-optical sensor unit for transcutaneous measurement of a concentration of a gas, comprising: at least one gas-permeable sensing layer adapted to be irradiated with a predetermined radiation; and at least a first gas-permeable layer adjacent to one side of the at least one sensing layer, adapted to pass gas whose concentration is to be measured through the gas-permeable layer towards the sensing layer; at least one volatile acid and/or base binding layer in the gas-pathway from the skin to the sensing layer; adapted to pass gas whose concentration is to be measured through the volatile acid and/or base binding layer towards the sensing layer; wherein said chemo-optical sensor unit is adapted to operate with a contact medium between the chemo-optical sensor unit and the skin and wherein the chemo-optical sensor unit is adapted to measure an optical response of the at least one sensing layer, whose optical response depends on the concentration of the gas.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: February 12, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Josephus Arnoldus Henricus Maria Kahlman, Nicolaas Lambert, Hans Willem Van Kesteren
  • Patent number: 10197445
    Abstract: According to an example embodiment, a detector assembly for use in analysis of elemental composition of a sample by using optical emission spectroscopy is provided, the detector assembly including a rotatable element that is rotatable about an axis and that has attached thereto a laser source for generating laser pulses for invoking optical emission on a surface of the sample, the laser source arranged to generate laser pulses focused at a predefined distance from said axis at a predefined distance from a front end of the detector assembly, and a detector element for capturing optical emission invoked by said laser pulses.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: February 5, 2019
    Assignee: Hitachi High-Tech Analytical Science Limited
    Inventor: Jukka Hassi
  • Patent number: 10180425
    Abstract: A DNA ligand capable of structural changes upon binding to a target is used as a molecular switch with a SPFS (surface plasmon field-enhanced fluorescence spectroscopy) biosensor to realize one-step SPFS biosensing with rapid turnaround time. The SPFS biosensor has a thin metal film on a prism; when a light of a certain wavelength irradiates on the prism at a certain angle, a strong electrical field is generated at the surface of the metal film. The DNA is immobilized on the metal film surface with its free terminal modified with a fluorescent marker. Without the target, the DNA is folded and the fluorescent marker is located in the region of metal quenching near the metal surface. Upon binding to the target, the DNA is extended and the fluorescent marker is located in the region of enhanced electric field near the metal surface and emits a strong fluorescent signal.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: January 15, 2019
    Assignee: KONICA MINOLTA LABORATORY U.S.A., INC.
    Inventor: Noriaki Yamamoto
  • Patent number: 10101210
    Abstract: A portable analyzer determines composition of a sample and includes excitation means for invoking an optical emission from a surface of the sample, detector means for observing a selectable wavelength in said optical emission and for recording a detection signal that is descriptive of at least one characteristic of said optical emission at a selected wavelength, analysis means for determination of elemental composition of the sample on basis of one or more detection signals; and control means for carrying out a spectral analysis by operating the excitation means to generate the optical emission for recording respective detection signals at predefined wavelengths, operating the detector means to record the respective one or more detection signals at said one or more predefined wavelengths, and operating the analysis means to determine elemental composition of the sample on basis of said recorded detection signals.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: October 16, 2018
    Assignee: Hitachi High-Tech Analytical Science Limited
    Inventor: Tuomas Pylkkanen
  • Patent number: 10073034
    Abstract: The present invention relates to a method for measuring the lifetime of an excited state in a sample, in particular a fluorescence lifetime, and to an apparatus for carrying out such a method. First, an excitation pulse is generated and a sample region is illuminated with the excitation pulse. Then, a first digital data sequence is generated which is representative of the power-time profile of the excitation pulse, and a first switching instant is determined from the first digital data sequence. Moreover, the detection light emanating from the sample region is detected by a detector, and a second digital data sequence is generated which is representative of the power-time profile of the detection light, and a second switching instant is determined from the second digital data sequence. Finally, the time difference between the first and second switching instants is calculated.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: September 11, 2018
    Assignee: Leica Microsystems CMS GmbH
    Inventor: Bernd Widzgowski
  • Patent number: 10060777
    Abstract: An “air-data probe” system measures at least one component of freestream velocity by tracking the motion of a laser-induced breakdown (“LIB”) spark created in a freestream flow. Neutral density filters are positioned or deployed so that the brightness of the initial LIB spark doesn't over saturate the LIB sensor system. This allows for more consistent tracking of the LIB spark throughout the duration of the LIB spark, including the later stages where the LIB spark is not nearly as bright as the initial LIB spark, thereby allowing all or substantially all of the light generated by the LIB spark to reach the sensors. This provides for enhanced visibility and more accurate detection of the LIB spark over time and as air density changes.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: August 28, 2018
    Inventors: Alan B Cain, Stanislav Gordeyev, R. Mark Rennie
  • Patent number: 10052024
    Abstract: Provided is a biometric device which may include a light source unit configured to irradiate an organism with inspection light, a light-collection unit arranged facing a region on a surface of the organism and configured to spatially-integrally collect output light emitted from the region in accordance with the inspection light, and a light-reception unit configured to receive the collected output light.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: August 21, 2018
    Assignee: Sony Corporation
    Inventor: Hideo Sato
  • Patent number: 10025081
    Abstract: An objective and an illumination unit for selectable generation of an orthoscopic beam path proceeding through the objective for pointlike scanning illumination, and of a conoscopic beam path proceeding through the objective for evanescent illumination of an object are disclosed. The illumination unit has a light source for generating illuminating rays along an illuminating beam path; a displacement unit for deflecting the illuminating beam path; a scanning eyepiece, placed after the displacement unit for focusing the illuminating rays into an image plane of the scanning eyepiece; and a mirror surface arranged in the image plane of the scanning eyepiece, having a transparent region for generating the orthoscopic beam path and having an at least partly reflective region facing toward the scanning eyepiece for generating the conoscopic beam path from the illuminating beam path, the image plane is located in a plane conjugated with the exit pupil.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: July 17, 2018
    Assignee: Leica Microsystems CMS GmbH
    Inventors: Peter Euteneuer, Christian Schumann
  • Patent number: 10001440
    Abstract: An observation apparatus and an observation method are provided. The observation apparatus includes a light source that emits illumination light used to observe a specimen to which a fluorescent substance that specifically binds to or is expressed in a stimulus target has been supplied, an illumination optical system that radiates the illumination light emitted from the light source 11 onto the specimen, a deflecting device that changes an area of the specimen to be irradiated with the illumination light, a wavelength selecting section that selects the wavelength of illumination light to be radiated onto the specimen, an observation optical system that collects light from the specimen, a detector that detects the light collected by the observation optical system, an image processing section that generates an image from the light detected by the detector, and a control section that controls these components.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: June 19, 2018
    Assignee: OLYMPUS CORPORATION
    Inventor: Susumu Honda
  • Patent number: 9998692
    Abstract: A process is provided for providing high contrast motion picture imagery. The camera system includes a physical architecture that enables multiple sensors to simultaneously acquire a visual scene without parallax or dissimilar exposures. The system architecture enables current off the shelf components to be used to develop the architecture or a specific sensor array to be developed. The architecture includes optical components that split an incident light ray into multiple beams of varying intensity. Each respective split light ray is then attenuated further with neutral density filters for the wavelengths to be observed before the light ray impacts the respective pixel sights. A process has been developed to use the camera system architecture to stochastically recombine the acquired energy and estimate what the original energy was before attenuation. The process involves the development of an optimal non recursive weighting function that can be used and constructed into a lookup table.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 12, 2018
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: David J. Griffiths
  • Patent number: 9983120
    Abstract: An imaging section that detects the amount of light separated by a wavelength tunable interference filter to acquire a spectroscopic image (imaging device and light amount acquisition section) detects the amount of light successively separated for three wavelengths to acquire spectroscopic images for producing a combined image. A display controller causes a display section to display a combined image based on the spectroscopic images for producing the combined image. A specified position detection section identifies based on user's operation a specified position where a colorimetry result is to be outputted. The imaging section detects the amount of light successively separated for a plurality of wavelengths by the wavelength tunable interference filter to acquire spectroscopic images for colorimetry corresponding to the plurality of wavelengths. A colorimetry section measures the color in the specified position by using the amount of light obtained from each of the spectroscopic images for colorimetry.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: May 29, 2018
    Assignee: SEIKO EPSON CORPORATION
    Inventor: Tetsuo Tatsuda
  • Patent number: 9958395
    Abstract: This invention discloses an improved laser induced breakdown spectroscopy (LIBS) apparatus and method for the detection of mineral and metal contamination in liquid samples. The mineral and metal contaminant is first collected by filtering the liquid sample with a membrane filter. The membrane filter with the mineral and metal contaminant is then measured by a LIBS apparatus. The LIBS apparatus is based on a high repetition rate pulsed laser. The laser produces a train of laser pulses at a high repetition rate in the kHz (or even higher) range. When the laser beam hits the surface of the membrane filter, it generates several thousands of micro-plasma emissions per second. Synchronized miniature CCD array optical spectrometer modules collect the LIBS signal from these micro-plasma emissions. By adjusting the integration time of the spectrometer to cover a plurality of periods of the laser pulse train, the spectrometer integrates the LIBS signal produced by this plurality of laser pulses.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: May 1, 2018
    Assignee: BWT Property, Inc.
    Inventors: Xin Jack Zhou, Sean Xiaolu Wang, Qun Li
  • Patent number: 9952159
    Abstract: This invention discloses a laser induced breakdown spectroscopy (LIBS) apparatus based on high repetition rate pulsed laser. The laser produces a train of laser pulses at a high repetition rate in the kHz (or even higher) range. When the laser beam hits the biological sample, it generates several thousands of micro-plasmas per second. Synchronized miniature CCD array optical spectrometer modules collect the LIBS signal from these micro-plasmas. By adjusting the integration time of the spectrometer to cover a plurality of periods of the laser pulse train, the spectrometer integrates the LIBS signal produced by this plurality of laser pulses. Hence the intensity of the obtained LIBS spectrum can be greatly improved to increase the signal-to-noise ratio (SNR) and lower the level of detection (LOD).
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: April 24, 2018
    Assignee: BWT Property, Inc.
    Inventors: Sean Xiaolu Wang, Qun Li
  • Patent number: 9891173
    Abstract: A method for detecting an element in a sample using molecular emission by double pulse laser-induced breakdown spectroscopy is provided. The method includes observing emissions from molecules including the element to be detected. The method is particularly useful for detecting halogens, whose elemental emissions are difficult to detect, rare earth elements and boron.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: February 13, 2018
    Assignee: LASER DISTANCE SPECTROMETRY LTD.
    Inventors: Michael Gaft, Lev Nagli
  • Patent number: 9839361
    Abstract: Imaging, testing and/or analysis of subjects are facilitated with a capillary-access approach. According to an example embodiment, a capillary is implanted into a specimen and adapted to accept an optical probe to facilitate optical access into the specimen. In some applications, the capillary is implanted for use over time, with one or more different probes being inserted into the capillary at different times, while the capillary is implanted. Certain applications involve capillary implantation over weeks, months or longer. Other applications are directed to the passage of fluid to and/or from a sample via the capillary. Still other applications are directed to the passage of electrical information between the sample and an external arrangement, via an implanted capillary.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: December 12, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark Jacob Schnitzer, Juergen Claus Jung
  • Patent number: 9829692
    Abstract: An optical observation unit (1) has an illumination apparatus (43) for illuminating an observation object (3). The illumination apparatus (43, 143) has a light source (45) emitting illumination light with a first color temperature, and a spectral filter (49) that can be inserted in the illumination beam path. The spectral filter (49) converts the illumination light with the first color temperature into illumination light with a second color temperature. The illumination apparatus further has an attenuator (51) that can be inserted in the illumination beam path in place of the spectral filter (49) and has a transmission characteristic that leads to an intensity reduction of the illumination light with the first color temperature that corresponds to the intensity reduction of the illumination light with the second color temperature by way of the spectral filter (49).
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: November 28, 2017
    Assignee: CARL ZEISS MEDITEC AG
    Inventors: Peter Reimer, Thomas Kratzer, Stefan Ernsperger, Bruno Stich
  • Patent number: 9823129
    Abstract: A printer includes a spectroscope and a carriage moving unit. The spectroscope includes a wavelength-selective interference filter on which light from a measurement target is incident, and the carriage moving unit moves the spectroscope in an X direction with respect to the measurement target. If the measurement target is a color patch, the spectroscope performs spectrometry by changing a wavelength of light passing through the wavelength-selective interference filter in a first period during which the spectroscope is moved in the X direction, and passes light of an initial wavelength through the wavelength-selective interference filter at a start of measurement and at an end of measurement in the first period. A first output value that is a measured value from the spectrometry at the start of measurement is compared with a second output value that is a measured value from the spectrometry at the end of measurement.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: November 21, 2017
    Assignee: Seiko Epson Corporation
    Inventor: Ryohei Kuri
  • Patent number: 9797835
    Abstract: An in-situ on-line detection device and detection method for a long-distance metallurgical liquid metal component. The detection device comprises a front-end high-temperature resistant probe, a middle-end optical sensing device and a back-end control platform, wherein the head of the front-end high-temperature resistant probe is placed in a liquid metal, the tail thereof is coaxially connected to the middle-end optical sensing device, and an optical window is arranged in the connection position; and the middle-end optical sensing device is connected to the back-end control platform through a signal line. The detection device and detection method can provide a timely and valid message for quality control and a melting end, so that the detection time is greatly shortened, the detection distance can he adjusted extensively, the measurement result is accurate, and it can be achieved to measure components that are difficult to measure such as carbon, sulfur, phosphorous, etc.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: October 24, 2017
    Assignee: SHENYANG INSTITUTE OF AUTOMATION OF THE CHINESE ACADEMY OF SCIENCES
    Inventors: Lanxiang Sun, Haibin Yu, Yong Xin, Lifeng Qi, Yang Li, Zhibo Cong
  • Patent number: 9797776
    Abstract: This invention discloses a laser induced breakdown spectroscopy (LIBS) apparatus based on a high repetition rate pulsed laser. The laser produces a train of laser pulses at a high repetition rate in the kHz or even higher range. When the laser beam hits the sample, it generates several thousands of micro-plasma emissions per second. Synchronized miniature CCD array optical spectrometer modules collect the LIBS signal from these micro-plasma emissions. By adjusting the integration time of the spectrometer to cover a plurality of periods of the laser pulse train, the spectrometer integrates the LIBS signal produced by this plurality of laser pulses. Hence the intensity of the obtained LIBS spectrum can be greatly improved to increase the signal-to-noise ratio (SNR) and lower the limit of detection (LOD).
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: October 24, 2017
    Assignee: BWT Property, Inc.
    Inventors: Sean Xiaolu Wang, Qun Li
  • Patent number: 9766223
    Abstract: This invention provides new methods and apparatus for rapidly analyzing a single bioparticle or a plurality of bioparticles to assess their condition. The invention is enabled by an optical microcavity comprising reflective structures to confine light and bioparticles in the same space. Under resonance conditions, an electromagnetic standing wave is established in the microcavity to interact with the bioparticle. Means are provided to bring a bioparticle into the microcavity and to detect changes in the resonance condition with and without the bioparticle in the microcavity. Information about the bioparticle is obtained using the benefits of light interactions as fast, non-contacting, and non-destructive.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: September 19, 2017
    Inventor: Paul L. Gourley
  • Patent number: 9759661
    Abstract: In a device for the optical imaging of a sample, having at least one light source for excitation light in order to excite a fluorescent dye in a sample, which is held by a sample holder, for spontaneous emission of fluorescent light over a limited period of time in a spatial region having increased resolution, and for de-excitation light in order to de-excite the fluorescent dye again except for a residual zone that is reduced in size relative to the spatial region, wherein light from the sample having wavelengths other than those of the excitation light and of the de-excitation light is assignable to the spontaneous emission of fluorescent light from the residual zone of the spatial region (STED, GSD, etc.), the de-excitation light (3) is arranged to be transmitted in two parallel planes which are separated by a gap (2).
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: September 12, 2017
    Assignee: Hans-Ulrich Dodt
    Inventor: Hans-Ulrich Dodt
  • Patent number: 9738864
    Abstract: A device (10) for detecting the presence of at least one microorganism in the contents (101, 201) of a container (100, 200) comprising a wall with a translucent zone, said detection device (10) comprising: a) at least one light source (11), such as a light-emitting diode (LED), capable of illuminating the contents of the container (100, 200) by emitting an excitation light beam through the translucent zone of the container (100, 200); b) at least one detection means (12, 13, 14, 15), such as a photodiode, for detecting at least one reaction light beam emitted in response to the illumination of the contents (101, 201) of the container (100, 200); said at least one light source (11) and said at least one detection means (12, 13, 14, 15) being equipped with at least one connection means (105, 205), to connect said at least one light source (11) and said at least one detection means (12, 13, 14, 15) to the wall of the container (100, 200), in the translucent zone, said at least one detection means (12, 13, 14
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: August 22, 2017
    Assignee: Biomerieux
    Inventors: Bruno Colin, Corinne De La Foata, Jacques Dachaud, Fabienne Made
  • Patent number: 9739715
    Abstract: A method of setting a laser-light intensity value includes: emitting laser light, the laser light being excitation light, a fluorescent-dyed biological sample being irradiated with the excitation light and emitting light; detecting fluorescence emitted by the biological sample, and outputting a signal corresponding to a brightness value; prestoring relation information, the relation information including the plurality of laser-light intensity values, and information on at least one possible correlation between a phototoxicity degree and the brightness value in relation to each of the laser-light intensity values, the phototoxicity to the biological sample resulting from the laser light; generating a fluorescence image having the brightness value based on the output signal; calculating a brightness value representative of a ROI area based on the generated fluorescence image; and referring to the relation information, and determining a laser-light intensity value satisfying tolerance of the phototoxicity based
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: August 22, 2017
    Assignee: Sony Corporation
    Inventors: Shinji Watanabe, Kazuki Aisaka
  • Patent number: 9719933
    Abstract: A method of quantifying at least one property of interest of an oil sands ore sample is provided using a laser-induced breakdown spectroscopy (LIBS) method. The LIBS method may be applied to oil sands ore being conveyed prior to a slurry process to measure oil sand composition and provide information which may predict extraction characteristics. The LIBS method may be applied to oil sands core samples in a laboratory setting to reduce the cost and analysis time associated with conventional laboratory measurement techniques.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: August 1, 2017
    Assignees: SYNCRUDE CANADA LTD, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Richard Paproski, Aïssa Harhira, David Duford, Josette El Haddad, Darcy Daugela, Alain Blouin, Mohamad Sabsabi
  • Patent number: 9696260
    Abstract: An installation for spectroscopic measurement includes a focusing system (2) for focusing a laser beam (3) on a sample (4) for analysis and a system (17) for collecting and spectroscopically analyzing light rays emitted by the plasma (15), this system (17) including, in particular, an optical fiber (18) for collecting light. The installation also includes a motor-driven system (23) for moving the optical fiber (18), an optical imaging system (25) for imaging the plasma in the form of an image, and a processor and control unit (24). The unit (24) is capable of analyzing the image formed by the optical imaging system in order to select a zone of interest and controlling the motor-driven system (23) in order to place the optical fiber in a position enabling it to collect light coming from the selected zone of interest in the plasma.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: July 4, 2017
    Assignees: UNIVERSITE CLAUDE BERNARD LYON I, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Vincent Motto-Ros, Jin Yu
  • Patent number: 9658103
    Abstract: A measuring apparatus, comprising at least a first light source and a second light source for transmitting light; at least one light receiver for receiving light at least of a first received wavelength and a second received wavelength; at least one dispersing element for bending and/or refracting light; wherein the light transmitted by the light sources strikes the dispersing element and is so turned by the dispersing element that it strikes the light receiver. The first light source is arranged at a first angle relative to the dispersing element and the second light source at a second angle relative to the dispersing element, wherein the second angle differs from the first angle. The first angle is so embodied that the wavelength of the light turned by the dispersing element corresponds to the first received wavelength, and wherein the second angle is so embodied that the wavelength of the light turned by the dispersing element corresponds to the second received wavelength.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: May 23, 2017
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventor: Ralf Bernhard