Monochromatic (e.g., Laser) Patents (Class 356/318)
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Patent number: 7612350Abstract: A scanning microscope includes a light source unit that projects laser light, an optical system that converges and applies the laser light onto data obtaining points on a specimen, and a data obtaining order deciding unit that decides a data obtaining order such that adjacent data obtaining points are not consecutive in the data obtaining order. A scanning unit scans the laser light in accordance with the data obtaining order, a detector detects detection light from the data obtaining points, respectively, and a storage unit stores luminance information on the detection light detected by the detector in association with positional information on the data obtaining points, respectively. An image formation unit forms a two-dimensional image based on the stored associated luminance and positional information.Type: GrantFiled: January 12, 2006Date of Patent: November 3, 2009Assignee: Olympus CorporationInventor: Nobuhiro Takamizawa
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Patent number: 7609370Abstract: A single detector based spectroscopy system using FAST (fiber array spectral translator) fibers and two excitation sources in conjunction with a holographic spectrum analyzer (HSA) to obtain simultaneous and selective display of spectroscopic regions of interest. A sample can be illuminated with different laser excitation wavelengths and resulting multiple spectra can be comparatively observed on a single display screen for more fruitful analysis of sample spectral responses (and, hence, sample chemical or physical properties) under different excitations. The HSA may be configured to focus on user-selected spectral regions of interest from different such spectra and a single CCD detector may be configured to collect spectral data from all selected spectral regions of interest in corresponding portions of the CCD pixel array, thereby allowing subsequent simultaneous display of such selected spectral regions of interest.Type: GrantFiled: January 22, 2008Date of Patent: October 27, 2009Assignee: ChemImage CorporationInventors: Thomas Voigt, David Tuschel
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Patent number: 7609379Abstract: A system for detecting a chemical element within a material including at least one laser emission means for ionizing part of the material to generate fluorescence; at least one transmitting Bragg grating that filters the wavelength corresponding to the deexcitation wavelength of the element; and at least one photodiode that detects a line corresponding to the filtering wavelength, wherein the at least one Bragg grating is mobile to vary the filtering wavelength.Type: GrantFiled: September 30, 2005Date of Patent: October 27, 2009Assignee: Centre National de la Recherche Scientifique - CNRSInventors: Lionel Canioni, Stéphane Santran, Bruno Bousquet
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Publication number: 20090262345Abstract: The invention relates to an immersion probe (1) for a device for carrying out laser-induced plasma spectroscopy in a liquid or solid free-flowing material, such as a metallic melt, which immersion probe (1) has a tubular section (4) extending from a foot-side end (2) of the immersion probe (1) about a longitudinal axis (X) of the same and an opening for material to flow in. In order to be able to reliably determine, in particular, a chemical composition of a melt independently of an angle of inclination of the immersion probe with respect to a surface of the melt, it is provided according to the invention that the tubular section (4) is embodied essentially closed or closeable on the foot-side end (2) and has a lateral opening (5) through which the material can be inserted into the tubular section as a free flowing jet (12) directed at an angle (?) to the longitudinal axis (X).Type: ApplicationFiled: April 30, 2007Publication date: October 22, 2009Inventors: Johann Gruber, Max Dallinger
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Patent number: 7605920Abstract: Disclosed herein is a method of identifying a unidentified substance, comprising directing light from a light emitting source directly upon a stationary unidentified substance; collecting fluorescence from the unidentified substance in a detector; wherein the detector comprises a lock-in detection system; analyzing the fluorescence; and identifying the unidentified substance. Disclosed herein is a detection system comprising a light emitting source; a circuit board; wherein the trigger is operative to trigger a pulse of electrons from the circuit board to the light emitting source; a detector; and a central processing unit, wherein fluorescence generated from an unknown unidentified substance that is illuminated by light from the light emitting source is collected in the detector and analyzed in the central processing unit.Type: GrantFiled: January 29, 2007Date of Patent: October 20, 2009Assignee: GE Homeland Protection, Inc.Inventors: Steven Francis LeBoeuf, Alexei Vasilievich Vertiatchikh, Rui Chen, Radislav Alexandrovich Potyrailo
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Patent number: 7601539Abstract: A standard material that is used for judging an abnormal portion in a particle analyzer is described. The standard material comprises first standard particles to be fluorescence-stained by a fluorescence-staining treatment and second standard particles that have preliminarily contained a fluorescence dye. A method and an analyzer that can judge an abnormal portion in a particle analyzer by using such a standard material are also described.Type: GrantFiled: July 11, 2006Date of Patent: October 13, 2009Assignee: Sysmex CorporationInventor: Yasunori Kawate
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Patent number: 7602479Abstract: A light fluctuation measuring apparatus, comprising a parameter setting unit 2 which sets parameters of a microscopic image obtaining unit and/or parameters of a light emission measuring unit used for observing light emission in a desired area of a sample in time series, a parameter storage 4 which stores parameters, a mode selector 3 which selects one of a microscopic image obtaining mode for obtaining a microscopic image by a microscopic image obtaining unit, and a light emission measuring mode for observing light emission in a desired area by a light emission measuring unit, and a control unit 1 which reads parameters stored in the storage 4 based on a selected mode, inputs the parameter to a microscopic image obtaining unit or a light emission measuring unit, and controls these units.Type: GrantFiled: November 1, 2005Date of Patent: October 13, 2009Assignee: Olympus CorporationInventors: Ryuji Sawada, Yoshio Nakashima
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Patent number: 7599732Abstract: According to one embodiment of the invention, a method for biomedical imaging includes directing time-varying excitation light at a surface area of a light scattering material, the material comprising a fluorescent target. Time-varying emission light from the fluorescent target is detected, substantially at a two-dimensional sensor surface, in response to the time-varying excitation light stimulating the fluorescent target. The time-varying emission light is filtered to reject excitation light re-emitted from the material. A three-dimensional image of the fluorescent target is generated based on the detection substantially at the sensor surface.Type: GrantFiled: June 18, 2004Date of Patent: October 6, 2009Assignee: The Texas A&M University SystemInventors: Eva M. Sevick-Muraca, Alan B. Thompson, Roy Ranadhir
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Patent number: 7599048Abstract: Methods and systems for control and monitoring processing of semiconductor materials with a focused laser beam. Laser light may be focused on a sample to excite optical emission at the sample surface during processing, which may include laser processing. Optical emission spectra produced may be analyzed for various properties effectively during the process. For example, process effects such as chemical composition analysis, species concentration, depth profiling, homogeneity characterization and mapping, purity, and reactivity may be monitored by optical spectral analysis. The wavelength may be selected to be appropriate for the process effect chosen.Type: GrantFiled: March 21, 2007Date of Patent: October 6, 2009Assignee: WaferMasters, Inc.Inventors: Woo Sik Yoo, Kitaek Kang
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Publication number: 20090242798Abstract: A microscopy system is configured for creating 3D images from individually localized probe molecules. The microscopy system includes a sample stage, an activation light source, a readout light source, a beam splitting device, at least one camera, and a controller. The activation light source activates probes of at least one probe subset of photo-sensitive luminescent probes, and the readout light source causes luminescence light from the activated probes. The beam splitting device splits the luminescence light into at least two paths to create at least two detection planes that correspond to the same or different number of object planes of the sample. The camera detects simultaneously the at least two detection planes, the number of object planes being represented in the camera by the same number of recorded regions of interest. The controller is programmable to combine a signal from the regions of interest into a 3D data.Type: ApplicationFiled: April 1, 2008Publication date: October 1, 2009Applicants: The Jackson Laboratory, University of MaineInventors: Joerg Bewersdorf, Manuel F. Juette, Travis Gould, Sam T. Hess
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Patent number: 7595864Abstract: The invention relates to an apparatus and a process of using the said apparatus in the in-time air sampling, detection and identification of bioaereosols; wherein identification of the said aerosol is based on a multiphoton laser diagnostic technique in combination with the velocity and aerodynamic size of the particular bioaerosol.Type: GrantFiled: November 18, 2005Date of Patent: September 29, 2009Inventors: Jorge E. Gonzalez Cruz, Alfredo Ortiz Vega, Victor M. Salazar Izquierdo
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Patent number: 7595874Abstract: Detection of a rarely occurring event within one or more biological samples includes (a) processing each biological sample to provide a gellable liquid solution comprising concentrated biological sample and a flourochrome designed to associate with a rarely occurring event within the concentrated biological sample; (b) depositing the solution in a layer on a surface of a slide; and (c) scanning the solution on the slide with energy adapted to cause fluorescence of the flourochrome to detect potential instances of the rarely occurring event within the concentrated biological sample in the solution.Type: GrantFiled: February 8, 2007Date of Patent: September 29, 2009Assignee: Sciperio, Inc.Inventors: Vladimir M. Pelekhaty, Anatoliy Kachurin, William Warren, Kenneth Church, Heather Fahlenkamp, Russell Higbee
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Patent number: 7589839Abstract: A microscope examination apparatus is provided that includes a light source for emitting excitation light or illumination light to a specimen placed on a stage; an objective lens opposing the stage and capable of focusing fluorescence or reflected light from the specimen; an image-forming lens for forming an image of the specimen obtained by the objective lens; and an image-capturing unit for capturing the image of the specimen forming by the image-forming lens, wherein a plurality of the objective lenses having different magnifying powers is provided, and an objective-lens switching mechanism for switching among the objective lenses is provided, and wherein a plurality of the image-forming lenses having different magnifying powers is provided, and an image-forming-lens switching mechanism for switching among the image-forming lenses is provided.Type: GrantFiled: March 29, 2005Date of Patent: September 15, 2009Assignee: Olympus CorporationInventors: Yoshihiro Kawano, Keiji Shimizu, Minoru Sukekawa, Tsuyoshi Mochizuki, Susumu Honda, Kazuhiro Hayashi
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Patent number: 7583369Abstract: The present invention compensates a fluctuation of a light-emitting intensity of a light source. First splitting portions (12, 13) in the present invention are used to split lights emitted from the light source, and an excitation light with a specific wavelength (?Ex) is incident to a sample element 15. Second splitting portions (16, 17) are used to split the lights from the sample element portion, and a fluorescence detecting portion 18 is used to measure the fluorescence intensity (IEm). A reference light detecting portion 19 detects a specific wavelength (?R) of the lights without being selected by the first splitting portion, and then the light intensities detected by the reference light detecting portion are outputted and stored in a spectrum data storage portion 21. The intensity (IEx) of the excitation light is calculated according to the wavelength of the excitation light, the wavelength of the reference light, and the intensity of the reference light in the spectrum data.Type: GrantFiled: November 27, 2007Date of Patent: September 1, 2009Assignee: Shimadzu CorporationInventor: Masahide Gunji
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Patent number: 7582882Abstract: A method of spectrographic measurement is disclosed. The method generates light energy using a solid state low capacitance excitation source, the light energy being caused to fall on a sample to be assayed, causing the sample to output an output optical signal. The method generates a plurality of modulation frequencies, and a plurality of heterodyne frequencies to form a set of heterodyne signals at the heterodyne frequencies. Each of the heterodyne frequencies is associated with one of the modulation frequencies. Coupling the modulation frequencies to the excitation source, causes the excitation source to generate excitation energy modulated in intensity in proportion to the modulation frequencies. A sampling a portion of the substantially incoherent excitation energy forms a reference substantially incoherent excitation signal.Type: GrantFiled: July 19, 2005Date of Patent: September 1, 2009Assignee: Horiba Jobin Yvon, Inc.Inventors: David McLoskey, Glenn Baker, Jim Mattheis, Sal Atzeni
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Patent number: 7573570Abstract: A compact Raman and fluorescence spectroscopy system that uses a microprism or micromirror based optical structure to accomplish the introduction of excitation radiation with compactness and simplified system configuration for portable or mobile spectroscopy applications. A microprism may be glued to a surface location of a focusing lens in the system to directly receive the illumination signal without intervening optical components. Alternatively, the microprism may be simply placed in close physical proximity of the focusing lens without being glued thereto. On the other hand, a micromirror may be used instead of the microprism. The illuminating photons received by the microprism or micromirror may be directly transferred to the sample under investigation via the focusing lens. The compact system may be made portable and may further include an on-board spectrometer with or without a display unit. For chemical detecting applications, a detector (e.g.Type: GrantFiled: August 21, 2007Date of Patent: August 11, 2009Inventor: Jingyun Zhang
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Publication number: 20090180114Abstract: Fine particles such as nanoparticles and microparticles is irradiated to generate plasma by focusing an ultrashort pulse laser beam 15 emitted from a laser device 16. More preferably, the plasma is generated by a filament 14 generated in the ultrashort pulse laser beam 15. A constituent of the fine particles is measured based on an emission spectrum from the plasma.Type: ApplicationFiled: September 20, 2006Publication date: July 16, 2009Inventors: Takashi Fujii, Naohiko Goto, Megumi Miki, Takuya Nayuki, Koshichi Nemoto, Nobuyuki Tanaka
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Patent number: 7561265Abstract: An optical microscope according to a first embodiment of the present invention includes: a laser light source; a Y-directional scanning unit moving the light beam in a Y direction; an objective lens; a X-directional scanning unit moving the light beam in a X direction; a beam splitter provided in an optical path from the Y-directional scanning unit to the sample, and separating outgoing light out of the light beam incident on the sample, which exits from the sample toward the objective lens from the light beam incident on the sample from the laser light source; a spectroscope having an entrance slit extending along the Y direction and spatially dispersing the outgoing light passed through the entrance slit in accordance with a wavelength of the light; and a detector detecting the outgoing light dispersed by the spectroscope.Type: GrantFiled: December 1, 2006Date of Patent: July 14, 2009Inventors: Minoru Kobayashi, Taisuke Ota, Takahiro Ode
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Patent number: 7557917Abstract: A system for analyzing the chemical composition of a sample, comprising exciting a portion of the sample to generate atomic spectral emissions; a spectrometer for determining atomic emission characteristics; processor for receiving an output from the spectrometer, analyzing said output to determine atomic composition, said processor predicting at least one of (i) an origin of the sample, (ii) a treatment applied to said sample, (iii) a composition of the sample, and (iv) a feedback signal for controlling a process. Calibration samples are also provided for standardizing readings from the spectrometer.Type: GrantFiled: May 6, 2005Date of Patent: July 7, 2009Assignee: Collectors Universe, Inc.Inventor: Casper Beesley
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Patent number: 7548367Abstract: A laser active optronic system has an emission channel for the emission by an emission source of a laser beam which illuminates a target, and a receiving channel for receiving the wave backscattered by the target. An optical switching device is positioned in the receiving channel to receive the backscattered wave and has an optical gain medium and pumping means for pumping the gain medium. The gain medium is absorbent at the wavelength of the laser and becomes substantially transparent when it is pumped to allow the switching device to be actuated in the on mode or off mode respectively. A control unit for controlling the pumping means, allows the switching device to be actuated in the on mode in at least one temporal window of predetermined duration, triggered at a predetermined instant after the start of emission of the illuminating laser beam.Type: GrantFiled: December 9, 2004Date of Patent: June 16, 2009Assignee: ThalesInventors: Michel Papuchon, Jean-Paul Pocholle
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Publication number: 20090147256Abstract: To provide a laser scanning microscope capable of enhancing the degree of freedom of observation while keeping its structure simple. Accordingly, a laser scanning microscope includes a light source, a spectroscopic unit guiding light from the light source to a specimen and guiding the light from the specimen to a detector, light path switching units switching a light path between the spectroscopic unit and the specimen to one among a plurality of light paths with different routes, and a plurality of light deflecting units each disposed in each of the plurality of light paths.Type: ApplicationFiled: December 19, 2008Publication date: June 11, 2009Applicant: NIKON CORPORATIONInventor: Hisashi Okugawa
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Publication number: 20090147255Abstract: A method for testing a semiconductor device includes irradiating a transistor within the semiconductor device with a light beam, where the irradiating the transistor induces a current within the transistor, and, in response to the irradiating, detecting photon emission from the transistor. A semiconductor device testing system includes a light beam emitter which provides a light beam to a device under test (DUT) to induce a current in the DUT, a filter which receives a photon emission from the DUT and removes from the photon emission a reflected light beam that is reflected from the DUT to provide a filtered photon emission, and a photon detector which detects the filtered photon emission.Type: ApplicationFiled: December 7, 2007Publication date: June 11, 2009Inventors: Kent B. Erington, Kristofor J. Dickson
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Patent number: 7545494Abstract: A method for the ultrasensitive simultaneous measurement of nonlinear optical emission signals in one or two local dimensions wherein excitation light is irradiated in modulated form from at least one light source into an interactive space in which one or several emissions that are nonlinearly correlated with the excitement light can be excited. The light emanating from the interactive spaces is measured using a one or two-dimensional detector array. Measured data is then transmitted to a computer and formatted in a one or two-dimensional data matrix. Further, non-correlated portions of the light emanating from the interactive spaces that are linearly proportionate to the intensity of the excitement light available in the interactive spaces are separated from portions of the light emanating from the interactive spaces which are not linearly proportionate. The invention also relates to an analytical system for carrying out this method.Type: GrantFiled: July 1, 2003Date of Patent: June 9, 2009Assignee: Bayer Technology Services GmbHInventors: Markus Haiml, Laurent P. Balet, Gert L. Duveneck, Gerd Marowsky
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Publication number: 20090135418Abstract: An apparatus to measure spatially resolved the luminescence of a semiconductor sample, in particular a semiconductor wafer or any part thereof, includes a rotatable sample holder for the semiconductor sample. This rotatable sample holder is mounted on an xy stage, and a drive mechanism is used to rotate the sample holder rapidly during the measurement. A device excites luminescence light on the semiconductor sample, and an optical device guides a portion of the luminescence light to a detector. The surface of the semiconductor sample is located in the range of a focal point of the optical device. Using a fixation device, it is possible to remove the rotatable sample holder from the xy stage, when required, and to replace it by a cryostat with an optical window and a further semiconductor sample, so that the surface of the further semiconductor sample is essentially located in the focus point of optical device.Type: ApplicationFiled: November 17, 2008Publication date: May 28, 2009Inventor: THOMAS WOLFF
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Patent number: 7537732Abstract: Paper pulp is added to a stain solution. The stain solution and pulp fibers are mixed to form a slurry. Samples are removed from the slurry and are admixed with dilution water and a bleach. Then, the fibers are moved into a flow cell where they are subjected to a light source adapted to stimulate fluorescence from the stained pulp fiber. Before the fiber slurry enters the flow cell it is mixed with a dilution water of bleach to reduce background fluorescence. The fluorescent light is collimated and directed through a dichroic filter onto a fluorescence splitting dichroic filter.Type: GrantFiled: February 26, 2004Date of Patent: May 26, 2009Assignee: University of WashingtonInventors: Richard Gustafson, James B. Callis, Jeffrey D. Mathews, John Robinson, Carsten A. Bruckner, Kuntinee Suvamakich
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Publication number: 20090128807Abstract: A metallic structure is provided on a surface of a substrate. A component having a longer wavelength than excitation light is detected from luminescence from fixation positions of biomolecules and emitted from a material other than the biomolecules, and is used for photometrical analysis. As the structure, usable is a particulate (a metallic structure of a size not larger than a wavelength of the excitation light), a minute protrusion, or a thin film with minute apertures, which are made of a metal such as gold, chrome, silver or aluminum. In the case of the particulate or the minute protrusion, photoluminescence of the structure is detected with a biomolecule being fixed thereon. In the case of the thin film with minute apertures, Raman scattered light of specimen solution around the biomolecules, and photoluminescence of the metallic structure near the biomolecules are detected with biomolecules being fixed in the apertures.Type: ApplicationFiled: November 19, 2008Publication date: May 21, 2009Inventors: Tsuyoshi Sonehara, Satoshi Takahashi, Tomoyuki Sakai
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Patent number: 7535568Abstract: A biochip for implementing analysis on the basis of the distribution of a quantity of light of fluorescent light generated at sites disposed thereon, the biochip having, markers formed thereon and defined previously in a positional relationship relative to the sites; and a processor for recognizing positions of the sites on the biochip on the basis of the positions of the markers, wherein the markers are formed of at least one of dyes, pigment, metal colloid bonded to biopolymer, dyes bonded to biopolymer, and pigment bonded to biopolymer.Type: GrantFiled: September 21, 2006Date of Patent: May 19, 2009Assignee: Yokogawa Electric CorporationInventors: Yumiko Sugiyama, Takeo Tanaami
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Patent number: 7535565Abstract: A system and method for performing laser plasma spectroscopy on a surface of a component, particularly to detect, analyze, and determine the extent of deposit build up on turbomachine components protected by coatings that are susceptible to damage from infiltration of deposits. The system includes a laser energy source and a probe interconnected with the laser energy source to receive a laser beam therefrom and then direct the laser beam onto the surface of the component and scan an area of the surface while the component remains stationary. The probe is further configured to collect radiation emitted from a laser-induced plasma generated by the laser beam at the surface of the component. The system is further equipped to transmit the radiation from the probe and spectrally analyze the radiation.Type: GrantFiled: January 8, 2008Date of Patent: May 19, 2009Assignee: General Electric CompanyInventors: John Ruediger Mader Viertl, Warren Arthur Nelson
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Publication number: 20090122311Abstract: In one embodiment of the present invention, a flow cytometer includes a plurality of optical sources, each of which illuminates an excitation beam at a predetermined frequency having a wavelength and a phase different from another; and a guide member for guiding the excitation beams into the same incident optical path to focus onto a dyed particle. According to one aspect of an embodiment of the present invention, it is possible, without requiring introduction of the delay time, to detect a plurality of fluorescence excited at the cell particles labeled with a plurality of fluorescent labeling reagents, by a plurality of laser optical sources.Type: ApplicationFiled: August 2, 2006Publication date: May 14, 2009Inventor: Masahiko Kanda
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Publication number: 20090114805Abstract: A method for determining a chemical composition of a material in a borehole, the method including placing an analysis apparatus into the borehole; placing a sample of the material onto a metal surface of the apparatus; illuminating the sample at an interface between the sample and the metal surface with a first light beam and a second light beam; measuring sum frequency light generated from the illuminating; and analyzing the sum frequency light to determine the chemical composition of the material.Type: ApplicationFiled: November 1, 2007Publication date: May 7, 2009Applicant: BAKER HUGHES INCORPORATEDInventor: Sebastian Csutak
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Patent number: 7528607Abstract: A method and system for measuring the amount of energy released by a spark ignition system. This energy can be quantified spectroscopically by measuring the emission of cyanogen radicals in the presence of a ignition event and a known A/F ratio.Type: GrantFiled: February 15, 2006Date of Patent: May 5, 2009Assignee: Southwest Research InstituteInventor: Terrence F. Alger, II
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Publication number: 20090108235Abstract: The present invention provides semiconductor-nanoparticle-dispersed small silica glass particles that emit bright fluorescent light with high fluorescence quantum yield and high density, compared to the conventional semiconductor-nanoparticle-dispersed small glass particles, and that have excellent fluorescence intensity stability over time; and a process for preparing the same. The semiconductor-nanoparticle-dispersed silica glass particles have a mean particle size of not less than 10 nanometers and not more than 5 micrometers, and contain a hydrolyzed alkoxide and semiconductor nanoparticles at a concentration of not less than 2×10?5 mol/l and not more than 1×10?2 mol/l. The particles emit fluorescent light with a fluorescence quantum yield (quantum yield) of 25% or more (and 60% or more), when dispersed in a solution.Type: ApplicationFiled: September 21, 2006Publication date: April 30, 2009Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Masanori Ando, Norio Murase, Chunliang Li, Ping Yang
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Publication number: 20090103084Abstract: An oxygen sensor usable and accurate in solutions of up to pH 14 is featured. The sensor is fabricated by immobilizing a layer of polystyrene mixed with a fluorophore (e.g., Ruthenium tris(4,7-diphenyl-1,10-phenanthroline) dichloride) in a solvent such as dichloromethane. The mixture may be coated onto a structure such as a stainless steel sensor probe. In typical use, the inventive sensor probe is inserted into a flow cell through which the solution to be monitored flows. A blue LED light source having a wavelength of approximately 470 nm, and a spectrophotometer detector complete the sensor system. In operation, the fluorophore layer of the probe is illuminated by a blue LED light and the fluorescence is reflected back to the spectrophotometer. The monitored solution, typically an electroless gold plating bath, is pumped from the process equipment through the flow cell, and then back to the solution's origin.Type: ApplicationFiled: October 28, 2008Publication date: April 23, 2009Applicant: Research Foundation of State University of New YorkInventors: Omowunmi A. SADIK, Hongwu XU
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Patent number: 7518727Abstract: A system for detecting electromagnetic radiation from samples comprising: a plurality of sample volumes, each of said sample volumes confined within a portion of a capillary column; a plurality of electromagnetic radiation sources; a mirror for receiving electromagnetic radiation from the electromagnetic radiation sources and for reflecting the electromagnetic radiation to the sample volumes; a scanner attached to the mirror; a parabolic reflector for collecting sample electromagnetic radiation from the sample volumes, the sample electromagnetic radiation being generated as a result of interaction of the reflected electromagnetic radiation with the sample volumes; a plurality of filters for filtering the sample electromagnetic radiation; and a plurality of detectors for detecting sample electromagnetic radiation from the sample volumes, each of the detectors being configured to receive sample electromagnetic radiation that has passed through a corresponding one of the plurality of filters and generate a signaType: GrantFiled: February 28, 2007Date of Patent: April 14, 2009Assignee: Beckman Coulter, Inc.Inventors: Stephen L. Pentoney, Jr., David L. Yang
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Patent number: 7518710Abstract: A biological and chemical detection system is provided that detects and identifies biological and/or chemical particulates of interest. The biological and chemical detection system comprises a collector, a first optical device, a second optical device and a processor. The collector is configured to deposit particulates drawn from a fluid stream onto a sample substrate to define a sample area. The first optical device derives first data relative to at least a portion of the sample area, which is analyzed to determine at least one field of view and/or specific target location. The second optical device then interrogates the sample area at each determined target location, e.g., using Raman spectroscopy, to produce interrogation data.Type: GrantFiled: July 14, 2006Date of Patent: April 14, 2009Assignee: Battelle Memorial InstituteInventors: Johnway Gao, Jerome U. Gilberry, William A. Ivancic, John J. Kester, Joseph A. McClintock, Clark A. Morrow, Jason A. Schaefer
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Publication number: 20090086205Abstract: A spectroscopic detector includes a tunable light source, such as a continuously tunable, optical parametric oscillator laser; means for measuring the emitted radiation at a plurality of emission wavelengths to obtain a plurality of spectral measurement data; and a processor for processing the spectral measurement data, where the processor includes a multispectral data processing algorithm or is configured for 1) combining the plurality of spectral measurement data into a composite spectrum, and 2) applying the algorithm to the composite spectrum. The spectra such as resonant and near-resonant Raman Spectra that are acquired are more complete and contain more information. A powerful multispectral analysis code such as IHPS, CHOMPS, or ENN analyzes the acquired data points, examining details of the spectra that could not be handled by traditional methods.Type: ApplicationFiled: October 9, 2008Publication date: April 2, 2009Inventors: Jacob Grun, Sergei Nikitin, Charles K. Manka
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Patent number: 7508516Abstract: A site position can be detected using transmitted light or reflected light which does not include an excitation wavelength according to a configuration of a biochip 60. When reflected light is used, a light source 21 is actuated. Light from the light source 21 passes through a barrier filter 22 and is bent by a dichroic mirror 23 and passes through a dichroic mirror 3 and illuminates the biochip 60. The reflected light in the biochip 60 enters a CCD camera 13. An output signal of the CCD camera 13 is sent to a computation part 51 and a position of a site on the biochip 60 is detected in the computation part 51.Type: GrantFiled: September 27, 2006Date of Patent: March 24, 2009Assignee: Yokogawa Electric CorporationInventors: Yumiko Sugiyama, Takeo Tanaami
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Publication number: 20090066934Abstract: A biological and chemical detection system is provided that detects and identifies biological and/or chemical particulates of interest. The biological and chemical detection system comprises a collector, a first optical device, a second optical device and a processor. The collector is configured to deposit particulates drawn from a fluid stream onto a sample substrate to define a sample area. The first optical device derives first data relative to at least a portion of the sample area, which is analyzed to determine at least one field of view and/or specific target location. The second optical device then interrogates the sample area at each determined target location, e.g., using Raman spectroscopy, to produce interrogation data.Type: ApplicationFiled: July 14, 2006Publication date: March 12, 2009Inventors: Johnway Gao, Jerome U. Gilberry, William A. Ivancic, John J. Kester, Joseph A. McClintock, Clark A. Morrow, Jason A. Schaefer
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Publication number: 20090059222Abstract: The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.Type: ApplicationFiled: April 4, 2008Publication date: March 5, 2009Applicant: Network Biosystems, Inc.Inventors: Eugene Tan, Heung Chuan Lam, Valery Leonidovich Bogdanov, Gregory John Kellogg, John A. Wright, Ulrich Hans Thomann, Richard F. Selden
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Patent number: 7499153Abstract: The invention is related to the instrument for measuring a Raman signal of tissue, the instrument comprising a laser, a signal detection unit for measuring the Raman signal, and a fiber optic probe, wherein the fiber optic probe comprises one or more optical fibers for directing laser light onto the tissue and for collecting light that is scattered by the tissue and guiding the collected light away from the tissue towards the signal detection unit, wherein the fiber or fibers for collecting light have substantially no Raman signal in one or more parts of the 2500-3700 cm?1 spectral region, and wherein the detection unit records the Raman signal scattered by the tissue in said spectral region. The invention enables ex vivo, in vitro and in vivo analysis and diagnosis of atherosclerotic plaque and detection of tumor tissue with great advantages over current state-of-the-art technology.Type: GrantFiled: December 2, 2003Date of Patent: March 3, 2009Assignee: River Diagnostics B.V.Inventors: Gerwin Jan Puppels, Rolf Wolthuis, Senada Koljenovic
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Patent number: 7492453Abstract: A system and method processes a structure comprising embedded material. The system includes a laser adapted to generate light and to irradiate an interaction region of the structure. The system further includes an optical system adapted to receive light from the interaction region and to generate a detection signal indicative of the presence of embedded material in the interaction region. The system further includes a controller operatively coupled to the laser and the optical system. The controller is adapted to receive the detection signal and to be responsive to the detection signal by selectively adjusting the laser.Type: GrantFiled: September 25, 2007Date of Patent: February 17, 2009Assignee: Loma Linda University Medical CenterInventors: Paul E. Denney, Jay R. Eastman, Ta-Chieh Huang
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Patent number: 7485846Abstract: A scanning microscope with a first and at least one other detection channel is disclosed. The first detection channel comprises at least one first detector and the other detection channel comprises at least one other detector to detect the detection light given off by a sample. A switching mechanism is provided that selectively directs the detection light into the first or into the other detection channel.Type: GrantFiled: September 27, 2005Date of Patent: February 3, 2009Assignee: Leica Microsystems CMS GmbHInventor: Frank Schreiber
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Patent number: 7482600Abstract: A method for investigating transport processes in a preferably biological specimen, a laser light beam (2, 3) being guided by means of a scanning apparatus line by line over the specimen within definable specimen regions, and the light proceeding from the specimen being detected by means of a detection apparatus, is characterized, in the interest of the capability of investigating, with high accuracy, processes within the specimen that proceed on a short time scale, in that both an image production light beam (5) for the purpose of observing the specimen and a manipulation light beam (4) for the purpose of manipulating the specimen are used as the laser light beam (2, 3), the image production light beam (5) preceding the manipulation light beam (4) in such a way that pixels of the specimen not yet manipulated by the manipulation light beam (4) are illuminated with the image production light beam (5).Type: GrantFiled: September 13, 2005Date of Patent: January 27, 2009Assignee: Leica Microsystems CMS GmbHInventor: Volker Seyfried
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Patent number: 7483131Abstract: An observation laser beam for observing a specimen and a manipulation laser beam for manipulating the specimen are multiplexed; the multiplexed beams irradiate the specimen, which is mounted on a stage, via an objective lens; and fluorescence emitted from inside the specimen in the observation optical axis direction is detected. In a preparation mode, a focal-position adjusting unit is controlled so that the focal position of the observation laser beam and the focal position of the manipulation laser beam are coincident, independent of the movement of the objective lens or the stage by a focusing mechanism; and in an observation mode, the focal-position adjusting unit is controlled so as to cancel out the shift of the focal position of the manipulation laser beam according to the movement of the objective lens or the stage.Type: GrantFiled: May 1, 2007Date of Patent: January 27, 2009Assignee: Olympus CorporationInventors: Nobuhiro Takamizawa, Tatsuo Nakata
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Publication number: 20090021731Abstract: A detection system is used during irradiation of an interaction region of a structure with laser light. The structure includes embedded material. The detection system includes means for receiving light emitted from the interaction region. The detection system further includes means for separating the received light into a spectrum of wavelengths. The detection system further includes means for analyzing at least a portion of the spectrum for indications of embedded material within the interaction region.Type: ApplicationFiled: September 25, 2007Publication date: January 22, 2009Inventors: Paul E. Denney, Jay R. Eastman, Ta-Chieh Huang
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Publication number: 20090022491Abstract: A light collecting device is disclosed that is able to couple light from a light emission structure to an optical fiber at low loss.Type: ApplicationFiled: September 19, 2007Publication date: January 22, 2009Applicant: FUJITSU LIMITEDInventor: Kazuya TAKEMOTO
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Patent number: 7480044Abstract: Device of modular construction which permits the simultaneous or not-simultaneous recording and characterization of solid and liquid particles and gaseous components of engine exhaust gases on various test supports, with only small or no modification of the test support. Methods are based on individual or combined usage of laser scattering techniques, laser-induced breakdown spectroscopy, laser-induced ionization spectroscopy, laser-induced atomic fluorescence spectroscopy, IR-/VIS-/UV-laser absorption spectroscopy and laser-induced incandescence. Use of individual or combined usage of such devices permits the analysis of raw exhaust gas, the conditioned and/or treated exhaust gases for monitoring and checking working pattern of engine, individual components of exhaust gas treatment and/or total system on test beds and on vehicle and can be used for control of motor and/or exhaust components, such as catalysts and particle filters, on test beds and in driven usage, e.g.Type: GrantFiled: July 25, 2006Date of Patent: January 20, 2009Assignee: Esytec Energie—und Systemtechnik GmbHInventor: Alfred Leipertz
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Patent number: 7480045Abstract: A method for imaging a sample is described. The sample is characterized by a limit on incident optical energy absorbed over a given time period. The method includes providing at least one input optical wave that includes pulses that each have a full-width half-maximum time duration of more than 100 picoseconds and a pulse energy sufficiently large such that a sufficient number of consecutive pulses absorbed by the sample would exceed the limit. The method also includes directing the input optical wave to focus on a first portion of the sample; detecting energy from an output optical wave generated from a nonlinear optical interaction in the first portion of the sample with the input optical wave; and generating a representation of the first portion of the sample based on the detected energy from the output optical wave.Type: GrantFiled: October 31, 2006Date of Patent: January 20, 2009Assignee: Academia SinicaInventors: Andy Kung, Tse-Luen Wee, Shu-Wei Huang
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Publication number: 20090015830Abstract: Methods and devices are provided for profiling a beam of light that includes a wavelength ?. The beam of light is received. Secondary light is generated at a wavelength ?? different from wavelength ? by fluorescing a material with the received beam of light. The secondary light is separated from the received beam of light. The separated secondary light is optically directed to a sensor.Type: ApplicationFiled: August 29, 2008Publication date: January 15, 2009Applicant: Applied Materials, Inc.Inventors: Timothy N. Thomas, Bruce Adams, Dean C. Jennings
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Patent number: 7477379Abstract: Pulse laser light transmitted through a laser light transmission optical fiber to an optical system unit passes through a distribution reflecting mirror and is condensed by a condenser lens group. The condenser lens group irradiates the condensed laser light onto an analysis object. The fluorescence emitted as a result of the irradiation of the pulse laser light onto the analysis object is condensed by the condenser lens group and is reflected by the distribution reflecting mirror. The optical system unit transmits the fluorescence reflected by the distribution reflecting mirror through an fluorescence transmission optical fiber to a fluorescence measuring instrument. The fluorescence measuring instrument determines the quantity of elements included in the analysis object on the basis of the fluorescence.Type: GrantFiled: June 26, 2007Date of Patent: January 13, 2009Assignees: Kabushiki Kaisha Toshiba, Toshiba Electron Tubes & Devices Co., Ltd.Inventors: Ryoichi Ootani, Makoto Ishibashi