Abstract: This invention relates to optical cell geometry and to the arrangement of optical elements in an absorbance (at 200 nm to 50000 nm) detector. The invention allows to significantly expand the dynamic range of an optical density measuring instrument without affecting the signal to noise ratio. The invention also allows to enhance the precision of said instrument by eliminating the artifacts that arise from partial reflections of the incident beam, which occur on the passage of the beam through interfaces between different media.

Abstract: The invention relates to a device (1) for photometrically or spectrometrically examining a liquid sample (2), comprising a cuvette (3, 3?), which can be arranged in the beam path between a radiation source (4) and a radiation detector (5) and which accommodates the liquid sample (2) to be examined, a radiolucent inlet section (6) for coupling in radiation (20) produced by means of the radiation source (4), which radiation interacts with a sample volume (8), and a radiolucent outlet section (7) for coupling out radiation (20?) intended to be detected in the radiation detector (5), wherein the inlet section (6) has an inlet surface (11) convexly curved in such a way and/or the outlet section (7) has an outlet surface (12, 12?) spherically convexly curved in such a way that the incident radiation (20, 20?) is focused in the manner of a converging lens.

Abstract: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.

Abstract: A fine particle measuring method of performing optical measurement of fine particles introduced into a plurality of sample fluidic channels provided at predetermined distances on a substrate by scanning light to the sample fluidic channels is disclosed. The method includes: sequentially irradiating the light to at least two or more reference regions provided together with the sample fluidic channels; detecting a change of optical property occurring in the light due to the reference regions; and controlling timing of emission of the light to the sample fluidic channels.

Abstract: An optical device, particularly a polarimeter, is provided for analyzing a liquid sample, having: a light-generating system for generating light for the surface irradiation of the sample; a detection system which is set up for the spatially resolved detection of light which originates from the transmission of the light provided for the surface irradiation through the sample; a telecentric optical system with a lens between the sample and the detection system and with an aperture diaphragm in the focal plane of the lens between the lens and the detection system.

Abstract: An optical probe for measuring physical and chemical characteristics of a transparent fluid medium during flow comprises two fingers parallel to one another and to the flow. Each finger consists of a solid bar of transparent material, in which a light beam propagates and is reflected on an end face of the bar, said face being situated upstream in the flow. Such an optical probe may be reduced in size, and provides results which are less sensitive to disturbances of the flow that are caused by the probe itself.

Abstract: The embodiments of the present invention are directed to addressing the complexity, sample geometry, and even pressure feedback issues associated with mechanical-only mechanisms. In particular, by utilizing one or more bellows capsules in an attenuated total internal reflection (ATR) instrument as a pressure vessel that can expand, contract, and tilt in all directions, the mechanisms disclosed herein can substantially apply uniform pressure to an interposed sample surface to include non-orthogonal sample surfaces, and thus conform to any sample geometry within such instruments. The result of the novel arrangements described herein is to provide a user with a convenient and simple interface for operating the interrogating ATR optical instrument.

Abstract: Self-aligning light source and detector assembly having a sensor support mounted in a predetermined, fixed position, a light source holder mounted in a predetermined, fixed position relative to the sensor support, a sensor mounted in a fixed position on the sensor support, and a lamp assembly removably mounted to the light source holder in a predetermined position defined by mating surfaces which engage each other and seat the lamp assembly in the predetermined position whenever the lamp assembly is installed in the holder.

Abstract: Methods and apparatuses for measuring a light absorbance are provided. The method measures light absorbance of at least one detection chamber of a microfluidic device, including the detection chamber and at least one reference chamber. The detection chamber may accommodate a test subject. The method includes detecting a plurality of reference transmitted light intensities for the at least one reference chamber and estimating a value between the plurality of reference transmitted light intensities through nonlinear approximation. The estimated value is then applied to light absorbance measurement of the detection chamber to reduce a light absorbance error of the detection chamber.

Abstract: A device, system and method to measure an optical characteristic of a fluid, the device including a plurality of components consecutively arranged and coupled together via quasi kinematic or kinematic coupling. The consecutively arranged components define a void within the device. The void encloses a measuring set-up for measuring at least one optical characteristic of a fluid passing through a gap. The gap is located at an intersection between an optical path of the measuring set-up and a flow path of the fluid.

Abstract: In one embodiment, a block for a physics package of an atomic sensor is provided. The block comprises one or more sections of optically transparent material defining a vacuum sealed chamber, and including a plurality of transmissive and reflective surfaces to define a plurality of light paths intersecting the vacuum sealed chamber. The one or more sections of optically transparent material include a first monolithic section defining at least a portion of the vacuum sealed chamber. The first monolithic section includes a first portion disposed across a first light path of the plurality of light paths such that light in the first light path is incident on the first portion of the first monolithic section.

Abstract: The present invention is directed to devices and methods for performing photoreactions of photo-reacting compounds in solution. The invention features a vessel defining a chamber and a light source. The chamber has a chamber volume, a first window, an inlet and an outlet. The inlet is placed in fluid communication with a source of photo-reacting compounds in solution. The first window is transparent to light transmission and is placed in optical communication with a light source to receive photons. The chamber receives a solution of one or more photo-reactive compounds over time to define a dwell time. The device further includes a light source, in optical communication with the first window, for emitting photons which photons are received by the first window and transmitted into the chamber.

Abstract: In various embodiments of the invention, a unique construction for Light Emitting Diodes (LEDs) with at least one luminescent rod and extracting optical elements used to generate a variety of high brightness light sources with different emission spectra. In an embodiment of the invention, forced air cooling is used to cool the luminescent rod. In an embodiment of the invention, totally internal reflected light can be redirected outward and refocused. In another embodiment of the invention, light emitted by the luminescent rod is out-coupled for use in a variety of applications.

Abstract: Inline optical sensor which includes a modular flowcell block with a flow passageway of predetermined diameter, interchangeable adapters for connecting flow lines with different internal diameters to the block, and an optical pathlength that can be adjusted both in fixed increments with window spacers and continuously with vernier adjusters, and a light source and an optical detector in modular housings which can be aligned both radially and axially. Thermal isolation is provided between the housings and the flowcell body, and air circulation further reduces temperature and condensation within the housings.

Abstract: An apparatus and method for estimating a parameter of interest in a downhole fluid using fluid testing module. The fluid testing module may include: a substrate comprising at least one microconduit, and a sensor. The sensor may be disposed within the at least one microconduit or external. The apparatus may include a fluid transporter for moving fluid within the microconduit. The method includes estimating a parameter of interest using the fluid testing module.

Abstract: An optical multi-pass cell (100) including a sample cavity (109) is provided. The cell (100) also includes first and second end mirrors (103, 104) positioned within the housing (101). The mirrors (103, 104) are configured to reflect a beam of light directed at one of the first or second end mirrors (103, 104) off-axis from the optical axis (113) one or more times between the end mirrors (103, 104) through the sample cavity (109) at a first distance from the optical axis (113) to create a first beam pattern (330). The cell (100) also includes one or more relay minors (220) positioned to intercept reflect the beam of light such that at least a second beam pattern (331) is created between the end mirrors (103, 104) at a distance from the optical axis (113) different from the first distance of the first beam pattern (330).

Abstract: A miniature flow-through cuvette for spectrophotometric measurement of a liquid sample includes a cuvette body of a transparent material including a first outer surface and an opposing second outer surface, and a flow channel disposed through the cuvette body. The flow channel includes first and second interface segments generally vertically oriented, each having an open exit; a measurement segment interconnecting the first and second interface segments; a first inclined planar inner surface disposed in a turning segment between the first interface segment and the measurement segment, facing the first outer surface; and a second inclined planar inner surface disposed in a turning segment between the second interface segment and the measurement segment, facing the second outer surface. The first and second inclined inner surfaces terminate the measurement segment at opposing ends thereof. Further provided is a spectrophotometer including the miniature flow-through cuvette.

Abstract: A cuvette is shaped cylindrically at one end in order to be placed in a standard microfuge and is designed to specifically remove unwanted contaminates by centrifugation. The lower part of the cuvette is shaped substantially smaller to collect liquids for direct analysis and has a shape that will conform to a variety of spectrophotometers for the measurement of the absorption of irradiation and at times the subsequent scattering of light from the liquid samples which at least in the regions of the windows or desired shape is of a transparent plastic or glass with an inner space. The upper opening of the cuvette is for filling and removing sample fluid and sample preparation in a centrifuge and the lower part projects downwards towards the floor of the measuring chamber and which comprises a smaller cross section than the upper part. A cuvette holder is designed to conform to the shape of the cuvette with an outer surface to conform to the specific measuring device.

Abstract: A device consisting of a rotatable substrate (10) with at least one cavity (14) or channel/chamber structures is described. Fluids may be provided into the at least one cavity (14) and on rotation of the substrate will experience the effects of pseudo forces. At least one functional element (15, 16) which is based on organic conductors as for instance an LED or a photodiode is connected with the rotatable substrate.

Abstract: A microfabricated analysis chip with integrated waveguides for evanescent field absorption detection is provided. Fabrication of the microfluidic device may be performed by micropatterning a layer of photoresist or other suitable material using a single step photoresist process to produce a microchannel and an optical structure (e.g., a U-bend waveguide) in the microfluidic device. The microfluidic device couples a micro-channel network with a waveguide in a collinear fashion to maintain higher path length and incurring little or no scattering, dispersion, and divergence losses. A sample can be passed through the microchannel while light is transmitted through the waveguide. Any change in refractive index as well as change in optical absorbance property of fluid flowing in the microchannel can be detected by detecting changes in light output power (e.g., changes in absorbance). A change in concentration of solution in the microchannel can be determined by detecting a change in light absorbance output.

Abstract: An optical detection system for monitoring real-time PCR reactions in a plurality of sample chambers with a plurality of optical units is provided. Due to a relative movement, the optical units are relative to the sample chambers, color multiplexing and space multiplexing are combined for optically detecting pathogens in a sample during the process of the PCR and delivering a quantitative result.

Abstract: A method for forming a nanostructure penetrating a layer and the device made thereof is disclosed. In one aspect, the device has a substrate, a layer present thereon, and a nanostructure penetrating the layer. The nanostructure defines a nanoscale passageway through which a molecule to be analyzed can pass through. The nanostructure has, in cross-sectional view, a substantially triangular shape. This shape is particularly achieved by growth of an epitaxial layer having crystal facets defining tilted sidewalls of the nanostructure. It is highly suitably for use for optical characterization of molecular structure, particularly with surface plasmon enhanced transmission spectroscopy.

Abstract: An illustrative cavity ring down gas sensor includes an optical cavity for receiving a gas to be detected and at least two electromagnetic radiation sources. The first electromagnetic radiation source may emit a first beam of light having a wavelength corresponding to an absorption wavelength of the gas to be detected, and the second electromagnetic radiation source may emit a second beam of light having a second wavelength that is off of an absorption wavelength of the gas to be detected. The first beam of light may detect a cavity ring down time decay, which is related to the concentration of the gas to be detected. The second beam of light may be used to detect a baseline cavity ring down time decay, which may be used to help increase the accuracy of the sensor by, for example, helping to compensate the concentration of the gas detected by the first beam of light for sensor variations caused by, for example, sensor age, temperature or pressure changes, and/or other conditions.

Abstract: A method and system for recreating a two-dimensional distribution of temperatures in an exhaust plane of a gas turbine engine. Light transmission and detection pairs may be arranged in the annulus of the exhaust of the turbine engine in such a way that the individual rays form a two-dimensional mesh of beams across a sector of the exhaust. Based on the absorption of the rays, the temperature of the sector of the exhaust thru which the ray passes may be determined. Based on these determinations, an image that corresponds to the operation of the turbine engine may be generated.

Abstract: A cup assembly for holding a sample to be analyzed spectrochemically, includes a tubular longitudinal member which is disposed symmetrical about a central axis. The tubular member extends longitudinally between a first end and a second end. An indented peripheral flange is defined at the second end. The indented flange has an inverted L shaped cross-section. An annular collar extends longitudinally between a first end and a second end. An internal peripheral flange is defined at the first end. The internal flange has an inverted L shaped cross-section complementing the indented flange of the tubular member. When a substantially thin film is interposed between the second end of the tubular member and the first end of the annular collar, the film is retained between the sample cell body and the collar between the indented flange and the internal flange. The cup may have a funnel shaped sample retaining chamber.

Abstract: This disclosure relates generally to a sampling device, and more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software controlled algorithms and methods for such a device.

Abstract: An optical waveguide is provided comprising a non-solid core layer surrounded by a solid-state material, wherein light can be transmitted with low loss through the non-solid core layer. A vapor reservoir is in communication with the optical waveguide. One implementation of the invention employs a monolithically integrated vapor cell, e.g., an alkali vapor cell, using anti-resonant reflecting optical waveguides, or ARROW waveguides, on a substrate.

Abstract: The present invention relates to an apparatus for sensing precipitation density of sludge in a wastewater treatment tank, more particularly to an apparatus and method for precisely taking density of sludge precipitated in a wastewater treatment tank without being contaminated by sludge. The present invention of an apparatus for sensing precipitation density of sludge in a waste water treatment tank comprises a container which is tube-shaped with a bottom thereof open and submerged in wastewater as filled with gas therein; and a sensor which is installed in the space in the container, and senses sludge density as not directly contacting with wastewater.

Abstract: Method of optically analysing a sample by directing one or more frequencies of electromagnetic radiation (EMR) through a sample and onto a partially reflective surface that allows EMR directed thereon to be both reflected and transmitted. The reflected EMR is directed back through the sample such that the pathlength through the sample is different for the transmitted EMR and reflected EMR. The transmitted EMR and reflected EMP are both detected by one or more detectors. The optical absorbance of the sample at the one or more wavelengths of EMR is calculated from the difference between the transmitted EMR and reflected EMR.

Abstract: A system for the rapid analysis of microbiological parameters includes a specimen container for containing a liquid sample, a housing having an enclosable chamber shaped for receiving the specimen container, an incubating system mounted within the housing for incubating microbiological materials within the liquid sample, and a spectrophotometer system mounted within the housing for measuring light absorbed, emitted or scattered by the liquid samples as the microbiological materials are incubated by the incubating system over time. The specimen container is filled with a liquid sample to be tested and mixed with a reagent that provides a detectable parameter, and placed inside the apparatus. The incubation system heats and maintains the temperature of the liquid sample within a preset range while the spectrophotometer system propagates light within the specimen container, and monitors and records changes in the light as the light propagates through the container.

Abstract: A sample analysis apparatus configured to automatically press a start button upon installation of a sample tube is provided. The sample analysis apparatus includes: a body of the sample analysis apparatus; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge; a tube accommodating unit included in the door housing and configured to accommodate the sample tube; a start button included in the body of the sample analysis apparatus and configured to start analysis of the sample; and an operating member positioned at a first position which is distant from the start button the sample tube is not installed in the tube accommodating unit, and a second position which is configured to operate the start button when a sample tube is installed and the door housing is closed.

Abstract: A signal detection system configured for detecting a signal emitted by the contents of a reaction receptacle is also configured to apply thermal energy to a portion of the reaction receptacle to affect a reaction occurring within the reaction receptacle. More particularly, a system for detecting electromagnetic radiation emitted by the contents of a reaction receptacle includes a transmission element configured for transmitting electromagnetic radiation from the contents of the receptacle, a thermal element associated with the transmission element and configured to apply thermal energy to at least a portion of the receptacle, and a detector configured to receive electromagnetic radiation from the transmission element and to generate a signal corresponding to a characteristic of the electromagnetic radiation received by the detector.

Abstract: A photoacoustic detector for providing a measurement, includes a first light source and a second light source each configured to provide light of a same intensity while retaining a same spectral distribution. Additionally, the photoacoustic detector includes a first beam path allocated to the first light source and at least one second beam path allocated to the second light source, wherein a different absorption of light occurs in the first path and the second beam path in at least one selected wavelength range. Further, the photoacoustic detector includes a photoacoustic measuring cell; and a mechanism for alternately guiding light from the first beam path and from the second beam path into the photoacoustic measuring cell.

Abstract: A valid state of an analytical system that includes a light source and a detector can be verified by determining that deviation of first light intensity data quantifying a first intensity of light received at the detector from the light source after the light has passed at least once through each of a reference gas in a validation cell and a zero gas from a stored data set does not exceed a pre-defined threshold deviation. The stored data set can represent at least one previous measurement collected during a previous instrument validation process performed on the analytical system. The reference gas can include a known amount of an analyte. A concentration of the analyte in a sample gas can be determined by correcting second light intensity data quantifying a second intensity of the light received at the detector after the light passes at least once through each of the reference gas in the validation cell and a sample gas containing an unknown concentration of the analyte compound.

Abstract: Optical flow cell detector comprising a sample inlet and outlet in fluidic communication through a flow cell channel of cross sectional area A, an input light guide with an light exit surface arranged adjacent and in optical alignment with a light entrance surface of an output light guide, wherein the input light guide and the output light guide protrudes into the flow cell channel and wherein the distance between the light exit surface and the light entrance surface is less than 1.0 mm, and wherein the cross sectional area of the protruding portions of the input light guide and the output light guide in the flow direction is less than A/2.

Abstract: The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.

Abstract: A calibration device and method of using the device to calibrate an analytical instrument capable of reading a photoluminescent oxygen probe. The device includes at least (a) a first mass of an oxygen sensitive photoluminescent dye retained within a hermetically sealed space so as to isolate the dye from environmental oxygen, and in fluid communication with an activated metal-air battery whereby any oxygen permeating into the hermetically sealed space is quickly consumed by the battery, and (b) a second mass of an oxygen sensitive photoluminescent dye in fluid communication with an environmental concentration of oxygen.

Abstract: Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected light is used to characterize the sample, for example, by detecting a light-related property thereof. In one implementation, the assaying arrangement includes integrated circuitry having a light detector and a programmable processor, with the light detector generating a signal corresponding to the light and sending the signal to the processor. The processor provides an output corresponding to the signal and indicative of a characteristic of the sample.

Abstract: Methods and apparatus for analyzing a sample using at least one detector are disclosed.

Abstract: Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique which may be used eliminates the aperture layer covering the light detector layer. Other techniques retain the aperture layer, reversing the relative position of the light source and light detector such that light passes through the aperture layer before passing through the fluid channel to the light detector. Another technique adds an optical tweezer for controlling the movement of objects moving through the fluid channel. Another technique adds an optical fiber bundle to relay light from light transmissive regions to a remote light detector. Another technique adds two electrodes at ends of the fluid channel to generate an electrical field capable of moving objects through the fluid channel while suppressing rotation. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.

Abstract: In a particle analyzing apparatus including a capillary for passing through a fluid containing particles to be analyzed, an optical system is employed to collect fluorescent light emitted from particles or substances labeled to the particles with improved collection efficiency preserving resolution of the instrument. The optical system may include a first collection lens attached to the capillary and a first reflection element arranged adjacent to the first collection lens configured to reflect fluorescent light of one or more wavelengths. The optical system may include a second collection lens attached to the capillary and a second reflection element arranged adjacent to the second collection lens configured to reflect fluorescent light of one or more wavelengths.

Abstract: Methods and apparatus for analyzing a sample using at least one detector are disclosed.

Abstract: Methods and apparatus for analyzing a sample using at least one detector are disclosed.

Abstract: A concentration measuring device for determining a concentration of gas or particles in a measurement volume includes at least one housing having an opening for communication with the measurement volume, a light source for transmitting measurement light through the housing into the measurement volume, a light receiver for receiving the measurement light after its passage through the measurement volume and an evaluation unit which is designed for determining the concentration of gas or particles from the measurement light received at the light receiver. In accordance with the invention at least one body of solid material is arranged in the at least one housing such that the measurement light path largely passes through the at least one solid body within the housing, with the portion of the measurement light path within the at least one housing not passing through the at least one solid body having a specified total length.

Abstract: A method and device for measuring trace levels of particles in an air sample is described. A device operating in a gradiometer configuration with two cavities built from a monolithic structure and utilizing a single probe laser, provides common mode subtraction of acoustic, vibrational, laser intensity and other noise sources, which allows sensitivity more closely approaching the quantum limit. Differential measurements between the two cavities occur simultaneously, which reduces errors due to cavity drift. Absorptive gradiometry can therefore provide noise immune detection for trace gasses, including broad linewidth absorbers where frequency-noise immune schemes are not practical. Differential measurements can be used for background subtraction, sensing vapor plum gradients and determining vapor plume propagation direction.

Abstract: A flow cell device includes a body having a hollow bore in which a liquid sample may reside. An electromagnetic beam may be directed through the body and into the bore to irradiate the liquid sample. The beam may be directed orthogonal to an axis of the bore. A light ray produced as a result of the irradiation may likewise be directed orthogonal to the bore axis along the same plane as the beam, and received by a detector. The body may be secured between a liquid inlet structure and a liquid outlet structure.

Abstract: A microchip which includes, a liquid flow path through which a liquid sample including a sample flows; and a gas flow path in which compressed gas flows, wherein liquid sample inlet which communicates with the starting end of the liquid flow path and a gas supply port which communicates with a terminal of the gas flow path are formed on the same plane, and a sealing material is disposed so as to enclose the liquid sample inlet and the gas supply port.

Abstract: A cuvette comprising a cuvette wall for limiting a sample reception space for receiving a fluid sample is disclosed. The cuvette wall is adapted to allow a traversal of measurement radiation through the fluid sample situated within the sample reception space. An information presenter is fixed at the cuvette wall. The information presenter wirelessly provides data to be transferred to an external data reception module. The data to be transferred relates to the cuvette. Further, an optical measurement apparatus is described.

Abstract: The invention relates to a detector for measuring scattered light in liquids having a housing, a transparent, flexible tube for transporting liquid through the housing, a light emitter, and a light detector. Two parallel surfaces are formed in the housing, between which the tube is arranged such that two opposing tube walls are formed in a planar parallel manner. The light emitter is arranged in such a way that the optical axis thereof is perpendicular to the parallel surfaces of the first tube wall, and the light detector is adjacent to the light emitter, the optical axes of the light emitter and light detector forming an angle smaller than 90°. The invention also relates to a method for detecting the presence of blood and for the quantitative determination of biological marker substances, especially bilirubin, in solution, and to a device for treating blood containing the detector.

Abstract: An optical measuring instrument includes: a flow channel for allowing a specimen to be circulated therein; a first light source including a light emitting diode for emitting light to be used for optical adjustment and/or image confirmation in the flow channel; a second light source for irradiating light upon the specimen circulated in the flow channel; and a light detector for detecting the spectrum intensity of the light emitted from the first and second light sources.