Illuminator Patents (Class 359/385)
  • Patent number: 10317663
    Abstract: The present approach relates to the measure of the planar tilt of a slide on a microscope using an integrated auto-focuser. The tilt of the slide can be used to detect improperly loaded slides (i.e. if the slide is resting on either the cover-slip or a printed barcode), compensate for misalignment between the microscope optical axis and the slide, and reduce subsequent focusing times.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: June 11, 2019
    Assignee: General Electric Company
    Inventor: Alex David Corwin
  • Patent number: 10310246
    Abstract: Improved image quality by structured illumination or pivoting illumination and faster image acquisition are both achieved. A line light enters first to fifth virtual pixels of a grating light valve, and first to fifth lights are emitted respectively from the first to fifth virtual pixels. The intensities and phases of the first to fifth 0th-order lights respectively depend on the arrangements of sub-pixels included in the first to fifth virtual pixels. The first to n-th 0th-order lights are extracted respectively from the first to n-th lights, and the first to n-th 0th-order lights are converted respectively into first to fifth light sheets. The first to fifth light sheets are created at a portion to be illuminated. The arrangements of the sub-pixels included in the first to fifth pixels are controlled such that a structured light sheet or pivoting light sheet is created at the portion to be illuminated.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: June 4, 2019
    Assignees: Screen Holdings Co., Ltd., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ryosuke Itoh, Olav Solgaard, Stephen Sanborn Hamann
  • Patent number: 10311568
    Abstract: An image processing apparatus includes an image acquisition unit adapted to acquire a radiation image capturing an object, a function acquisition unit adapted to acquire a point spread function from the radiation image, and a determination unit adapted to determine, based on a state of the point spread function, presence/absence of a movement of the object in the radiation image.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: June 4, 2019
    Assignee: Canon Kabushiki Kaisha
    Inventor: Hiroyuki Omi
  • Patent number: 10302928
    Abstract: A sample observation device includes an illumination optical system and an observation optical system. The illumination optical system includes a light source, a condenser lens, and an aperture member. The observation optical system includes an objective lens and an imaging lens. The aperture member has a light-shielding part or a darkening part, and a transmission part. The transmission part is disposed asymmetrically with respect to an optical axis of the illumination optical system. An image of an inner edge of the transmission part is formed inside of an outer edge of a pupil of the objective lens. An image of an outer edge of the transmission part is formed outside of the outer edge of the pupil of the objective lens.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: May 28, 2019
    Assignee: OLYMPUS CORPORATION
    Inventor: Yoshimasa Suzuki
  • Patent number: 10295814
    Abstract: A microscope including an illumination objective with a first optical axis, embodied to produce a light sheet, and a detection objective with a second optical axis, embodied to detect light coming from the specimen plane. The illumination objective and the detection objective are aligned relative to one another and the specimen plane so that the first and second optical axes intersect in the specimen plane and include a substantially right angle therebetween. The optical axes each include an angle which differs from zero with a reference axis directed orthogonal to the specimen plane. An overview illumination apparatus for wide-field illumination of the specimen plane, includes an illumination optical unit with a third optical axis. The characterizing feature is that the detection objective is provided to detect both light from the light sheet and light from the illumination optical unit. A method is also provided for operating a light sheet microscope.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: May 21, 2019
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Jörg Siebenmorgen, Helmut Lippert, Thomas Kalkbrenner
  • Patent number: 10281699
    Abstract: A microscope system includes an objective lens that focuses, on a specimen, illumination light produced by a light source. An illumination-area switching mechanism is disposed between the objective lens and the specimen and switches an illumination area irradiated with the illumination light focused by the objective lens among a plurality of illumination areas on the specimen that are located outside an objective optical axis of the objective lens. An inner focus lens is disposed on the objective optical axis between the light source and the objective lens and changes a focus position of the objective lens in a direction along the objective optical axis.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: May 7, 2019
    Assignee: Olympus Corporation
    Inventors: Tatsuo Nakata, Atsushi Doi, Kentaro Imoto
  • Patent number: 10247934
    Abstract: A method for examining a specimen via light sheet microscopy includes selecting several illumination wavelengths for the specimen. To structure the illumination light, a predefined phase distribution is impressed on the phase-selective element and a predefined aperture structure is impressed on an aperture in the aperture plane. The phase-selective element is then illuminated in an intermediate image plane in an illumination beam path with illumination light, which is structured by the phase-selective element. The structured illumination light is imaged into an aperture plane arranged downstream of the phase-selective element. The aperture structure is adapted such that the zero orders of the structured illumination light in the aperture plane are substantially removed. The specimen is illuminated with the structured light sheet in the light sheet plane. Light emitted by the specimen is detected in a detection direction which forms an angle different from zero with the light sheet plane.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: April 2, 2019
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Thomas Kalkbrenner, Helmut Lippert, Joerg Siebenmorgen
  • Patent number: 10222198
    Abstract: Provided is an optical coherence tomographic apparatus, including: a light source configured to generate light; a light splitting unit configured to split the light from the light source into reference light and measuring light; a detection unit configured to detect intensity of combined light obtained by combining the reference light with return light from an object to be inspected, which is irradiated with the measuring light; an image forming unit configured to form a tomographic image of the object to be inspected based on the detected intensity; and a locating unit configured to locate one of a plurality of objective lenses having different focal lengths and having the same dispersion amount on an optical axis at a position on an optical path of the measuring light opposed to the object to be inspected.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: March 5, 2019
    Assignee: Canon Kabushiki Kaisha
    Inventor: Yuji Katashiba
  • Patent number: 10188281
    Abstract: An observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a portion of the light-sensitive tissue upon being illuminated by the illumination system, and an image display system in communication with the imaging system to display an image of the portion of the light-sensitive tissue. The illumination system is configured to illuminate the light-sensitive tissue with a reduced amount of light within a preselected wavelength range compared to multispectral illumination light, and the image of the portion of the light-sensitive tissue is compensated for the reduced amount of light within the preselected frequency range to approximate an image of the light-sensitive tissue under the multispectral illumination.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: January 29, 2019
    Assignee: The Johns Hopkins University
    Inventors: Russell H. Taylor, Seth D. Billings, Peter L. Gehlbach, Gregory D. Hager, James T. Handa, Jin U. Kang, Balazs P. Vagvolgyi, Raphael Sznitman, Zachary Pezzementi
  • Patent number: 10175466
    Abstract: An image processing device includes a spatial frequency filtering process unit. The spatial frequency filtering process unit performs a spatial frequency filtering process on image data of a three-dimensional image of the observed object in accordance with the optical transfer characteristic of the microscope apparatus. The spatial frequency filtering process is a process of changing a spatial frequency characteristic included in the three-dimensional image. The three-dimensional image is constructed from a plurality of two-dimensional images of the observed object acquired by the microscope apparatus under a first illumination light amount distribution. The first illumination light amount distribution is formed by moving a condensing position of a light sheet in an illumination direction. The light sheet is emitted to the observed object from the illumination direction.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: January 8, 2019
    Assignee: OLYMPUS CORPORATION
    Inventor: Shinichi Hayashi
  • Patent number: 10174911
    Abstract: The present invention relates to a filter, a CMY color mixing assembly using the filter and an optical system thereof. Said filter comprises a substrate and a filtering film plated on the substrate, and the filtering film comprises a uniform region and a color mixing region. The thickness of the filtering film in the uniform region is uniform, while the thickness of the filtering film in the color mixing region is not uniform. The thickness of the filtering film in the uniform region is greater than or equal to the thickness of the filtering film in the color mixing region, and the thickness of the filtering film of a central region of the color mixing region is greater than the thickness of the filtering film of side regions of the color mixing region. Said color mixing region is provided at a side where the filter first accesses to a light path.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: January 8, 2019
    Assignees: Guangzhou Haoyang Electronic Co., Ltd.
    Inventor: Weikai Jiang
  • Patent number: 10168460
    Abstract: An optical construction includes a quantum dot film element including a plurality of quantum dots, a first optical recycling element, and a first low refractive index element separating the quantum dot film element from the first optical recycling element. The first low refractive index element has a refractive index of 1.3 or less.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: January 1, 2019
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Gilles J. Benoit, John A. Wheatley, James A. Thielen, David Scott Thompson
  • Patent number: 10133050
    Abstract: A sample observation device includes an illumination optical system and an observation optical system, and the illumination optical system includes a light source, a condenser lens and an aperture member, and the observation optical system includes an objective lens and an imaging lens, and the aperture member has a light-shielding part or a darkening part and a transmission part, and the aperture member is disposed so that the light-shielding part or the darkening part includes an optical axis of the illumination optical system, and an image of an inner edge of the transmission part is formed inside of an outer edge of the pupil of the objective lens, and an image of an outer edge of the transmission part is formed outside of the outer edge of the pupil of the objective lens.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: November 20, 2018
    Assignee: OLYMPUS CORPORATION
    Inventors: Yoshimasa Suzuki, Kazuo Kajitani
  • Patent number: 10114207
    Abstract: A three-dimensional information obtaining apparatus includes an illumination optical system that illuminates a sample with a light sheet, an imaging device that has a two-dimensional imaging element and that captures an image of the sample illuminated by the illumination optical system, an observation optical system that forms, on the two-dimensional imaging element, a plurality of optical images of the sample observed from a plurality of different directions, and an arithmetic device that calculates three-dimensional information of the sample from a plurality of pieces of image data of the sample. A thickness D of the light sheet satisfies D?8·PP/?/NA when PP>?·?/(4·NA) is satisfied, where PP is a pixel pitch of the two-dimensional imaging element, ? is a wavelength of observation light, ? is a magnification of the plurality of optical images, and NA is a numerical aperture on an object side of the observation optical system.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: October 30, 2018
    Assignee: OLYMPUS CORPORATION
    Inventor: Hiroshi Ishiwata
  • Patent number: 10088656
    Abstract: A stimulated-emission-depletion (STED) super-resolution microscope includes an excitation light source, a depletion light source, an excitation light expanded beam alignment system, a spiral-shaped phase plate, a Bessel beam generating system, a depletion light focus lens, a beam combination system, an objective lens, a piezoelectric scanning system, a filter, a signal collection system, and a single-photon detector. The depletion light can be a first-order Bessel beam. The depletion light has anti-scattering and self-healing characteristics, and is capable of keeping the spot shape at a deeper position of a sample, thereby improving image resolution in the deep region of the sample. Compared to conventional STED super resolution microscope of deep-layer imaging using an adjustable correction collar, the present invention is simpler in experimental operations and does not require active adjustments. Compared to adaptive optical systems, the present experimental apparatus is simpler and less expensive.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: October 2, 2018
    Assignee: Peking University
    Inventors: Kebin Shi, Peng Xi, Wentao Yu, Qihuang Gong
  • Patent number: 10082658
    Abstract: A high power microscopy illumination system is disclosed, having a liquid cooled, Solid State Light Source (SSLS) unit including one or more LED light sources, thermally mounted on a cold plate, which is cooled by a closed-loop liquid cooling system including a remote unit housing a heat exchanger. The SSLS unit with the LED light source is compact and lightweight, and is mechanically and optically directly coupled to the illumination port of the microscope, for efficient optical coupling to the imaging plane. High capacity cooling of the LEDs, enables the LEDs to be driven at higher current densities for increased optical output and for operation with improved thermal stability. The LED driver circuitry may also be housed within the SSLS unit and liquid cooled. The SSLS unit is vibrationally isolated from vibration-causing components of the cooling system, such as cooling fans and other bulky components, which are housed in the remote unit.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: September 25, 2018
    Assignee: Excelitas Canada, Inc.
    Inventor: Paul Constantinou
  • Patent number: 10073257
    Abstract: The invention relates to an apparatus for transmitted light illumination for light microscopes having changing effective entrance pupil of an objective. The apparatus has a light source for emitting an illuminating light beam, and a holding device for holding a sample to be examined, and at least one diaphragm edge for trimming the illuminating light beam bundle, wherein the diaphragm edge is arranged between the holding device and the light source and extends transversely to an optical axis, wherein a beam path of the illuminating light between the diaphragm edge and a sample held by the holding device is free from beam focussing components.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: September 11, 2018
    Assignee: CARL ZEISS MICROSCOPY GMBH
    Inventors: Detlef Hein, Axel Laschke
  • Patent number: 10042148
    Abstract: A light sheet microscope includes an illumination optical system that irradiates a light sheet onto a sample and a setting changer that changes a setting of a divergence angle or convergence angle relating to a width direction of the light sheet emitted from the illumination optical system.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: August 7, 2018
    Assignee: OLYMPUS CORPORATION
    Inventor: Yoshihito Iguchi
  • Patent number: 10031325
    Abstract: An arrangement for light sheet microscopy that includes a means for scanning a sample volume with a light sheet, which includes an angle ??90° with the optical axis of an objective. The light sheet passes through the entire sample volume in the propagation direction, and the depth of field Sobj of the objective is less than the optical-axis depth T of this sample volume. An optical device, disposed downstream of the objective, increases the depth of field Sobj to a depth of field Seff?the depth T of this sample volume. The arrangement also includes a means for positioning the sample volume within the region of the depth of field Seff. A spatially resolving optoelectronic area sensor is disposed downstream of the optical device, and hardware and software are provided to generate sample-volume images from the electronic image signals output by the area sensor.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: July 24, 2018
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Tiemo Anhut, Thomas Kalkbrenner, Daniel Schwedt, Jörg Siebenmorgen, Helmut Lippert
  • Patent number: 10018819
    Abstract: A light sheet illumination microscope includes an illumination optical system configured to illuminate a sample from a direction substantially perpendicular to an optical axis of a detection optical system. The illumination optical system includes a first optical element configured to convert light emitted from a light source into a light sheet that forms an illumination area having a sheet shape substantially perpendicular to the optical axis of the detection optical system when the sample is irradiated with the light sheet. The illumination optical system further includes a second optical element that configured to act on the light emitted from the light source such that the light sheet is converged, diverged or diffracted in a width direction of the light sheet.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: July 10, 2018
    Assignee: OLYMPUS CORPORATION
    Inventors: Yoshihito Iguchi, Yu Kikuchi
  • Patent number: 10012826
    Abstract: A method, in which a sample is manipulated with manipulation light, includes imaging the sample using a single plane illumination microscopy SPIM technique under illumination with illumination light being an illumination light sheet of fluorescent excitation light. Both the manipulation light and the illumination light are focused by an objective brought to an objective working position. Either the manipulation light or the illumination light are diverted after passing through the objective by use of a diverting device to propagate the manipulation light or the illumination light at an angle different from zero degrees with respect to an optical axis of the objective.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: July 3, 2018
    Assignee: Leica Microsystems CMS GmbH
    Inventors: Werner Knebel, Wernher Fouquet, Frank Sieckmann
  • Patent number: 9968262
    Abstract: A system for direct imaging and diagnosing of abnormal cells in a target tissue includes a disposable optical speculum and an image acquisition system having the speculum assembled on and mechanically secured thereto. The image acquisition system is arranged to capture at least one of a single image or multiple images or video of cells within the target tissue using at least one of bright field or dark field ring illumination divided into independently operated segments to obtain a plurality of data sets. An image analysis and control unit in communication with the image acquisition system analyzes the data sets and applies algorithms to the data sets for diagnosing abnormal cells.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: May 15, 2018
    Assignee: Illumigyn Ltd.
    Inventors: Lior Greenstein, Gilad A. Davara, Gad Ganon, David Aviv
  • Patent number: 9958658
    Abstract: Embodiments disclose a device for testing biological specimen. The device includes a sample carrier and a detachable cover. The sample carrier includes a specimen holding area. The detachable cover is placed on top of the specimen holding area. The detachable cover includes a magnifying component configured to align with the specimen holding area. The focal length of the magnifying component is from 0.1 mm to 3 mm. The magnifying component has a magnification ratio of at least 30.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: May 1, 2018
    Assignee: Bonraybio Co., Ltd.
    Inventors: Cheng-Teng Hsu, Hsuan-Yu Huang, Chih-Pin Chang, Kuang-Li Huang
  • Patent number: 9958665
    Abstract: Embodiments disclose a device for testing biological specimen. The device includes a sample carrier and a detachable cover. The sample carrier includes a specimen holding area. The detachable cover is placed on top of the specimen holding area. The detachable cover includes a magnifying component configured to align with the specimen holding area. The focal length of the magnifying component is from 0.1 mm to 8.5 mm. The magnifying component has a linear magnification ratio of at least 1.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: May 1, 2018
    Assignee: Bonraybio Co., Ltd.
    Inventors: Cheng-Teng Hsu, Hsuan-Yu Huang, Chih-Pin Chang, Kuang-Li Huang, Yu-Chiao Chi
  • Patent number: 9939563
    Abstract: A lighting system comprises a chromatic reflective unit (606), and a light source (602), wherein the chromatic reflective unit (606) is shaped as a rotational paraboloid or a portion of a rotational paraboloid, and the light source (602) is positioned close to or at the paraboloid focal position.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: April 10, 2018
    Assignee: CoeLux S.r.l.
    Inventors: Paolo Di Trapani, Davide Magatti, Antonio Lotti
  • Patent number: 9915815
    Abstract: A total internal reflection light illumination apparatus includes a light source providing illumination light L1, a spatial light modulator inputting the illumination light L1 and converging and outputting the illumination light L1 by presenting a lens pattern, an objective lens illuminating an object substrate with illumination light L2 converged and output by the spatial light modulator, and a calculation unit providing, to the spatial light modulator, the lens pattern corresponding to at least one of a desired polarization state, desired penetration length, desired shape, and desired light intensity of the evanescent light L3. The lens pattern converges the illumination light L2 on a pupil plane of the objective lens.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: March 13, 2018
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Koyo Watanabe, Naoya Matsumoto
  • Patent number: 9885862
    Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging. The microscope is adjustable, with a structure that can move along range(s) of motion and degree(s) of freedom to allow for ease of access to samples, shielding of samples, and manipulation of a display apparatus.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: February 6, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Frank Hsiung, Kelly Kroeger, Robert Archer, Veronika Kortisova, Teresa Rubio
  • Patent number: 9835839
    Abstract: An apparatus and method for transmitted light illumination for light microscopes having changing effective entrance pupil of an objective. The apparatus has a light source for emitting an illuminating light beam, wherein a beam path of the illuminating light between a diaphragm edge and a sample held by a holding device is free from adjustable beam focussing components. In order to adapt the beam path of the illuminating light to the effective entrance pupil of the objective, the diaphragm edge may be variably positioned in the direction of the optical axis, wherein a position of the diaphragm edge in the direction of the optical axis can be varied irrespectively of a position of the diaphragm edge transversely to the optical axis.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: December 5, 2017
    Assignee: CARL ZEISS MICROSCOPY GMBH
    Inventor: Detlef Hein
  • Patent number: 9817222
    Abstract: A microscope system includes a laser light source, a plurality of laser microscopes, and an optical path switching unit that is provided between the laser light source and the laser microscopes and switches a supply destination of a laser beam among the plurality of laser microscopes by changing a beam splitter to be arranged on an incident optical axis. Each of the laser microscopes includes an optical axis adjustment unit that adjusts an optical axis of the laser beam, and a control unit that controls the optical axis adjustment unit based on identification information about the beam splitter arranged on the incident optical axis.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: November 14, 2017
    Assignee: OLYMPUS CORPORATION
    Inventors: Shingo Suzuki, Takuma Kimura, Makio Ueno
  • Patent number: 9791687
    Abstract: A method for SPIM microscopy with a microscope winch includes (1) an illumination arrangement for illuminating a sample with a substantially planar light sheet, and (2) a detection arrangement for detecting light emitted by the sample with an objective. The sample is displaced through the light sheet in direction of the objective's optical axis, and the sample is illuminated under a first illumination angle and a second illumination angle. A plurality of sample planes are then detected at each illumination angle and stored as at least a first image stack and a second image stack. The image stacks are aligned relative to one another, and are combined in one image stack. A the three-dimensional image stack is projected into a two-dimensional rendering, sample features are aligned, a coordinate transformation is determined, and the coordinate transformation for alignment is applied to the combined image stack.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: October 17, 2017
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Stefan Schweinitzer, Philipp Sprengholz
  • Patent number: 9772225
    Abstract: A spectroscope device is provided to maintain the uniformity of the central transmitting wavelength in the field of view and to minimize the broaden of the bandwidth of the transmitting wavelengths in an optical lens using an optical tunable filter (variable wavelength filter), even with a wide field of view and/or a large numerical aperture. A space is defined in which, when each beam that is incident from each off-axial object point on the object surface toward the optical lens that includes a plurality of lens elements between an object surface and a conjugate real image surface reaches the optical tunable filter, the chief ray is maintained parallel to the optical axis. Therefore, if an optical tunable filter is disposed in this space, each beam is always incident normal to the filter, so only the narrow band components at the specific central wavelength can be transmitted.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: September 26, 2017
    Assignee: GENESIA CORPORATION
    Inventors: Norihide Takeyama, Yoshikazu Kanai, Daisuke Fukuoka
  • Patent number: 9772481
    Abstract: An arrangement for use in illuminating a sample in SPIM microscopy includes an illumination objective configured to receive and focus a light strip or a quasi-light strip. The quasi-light strip is made up of a light bundle continuously moved back and forth in a light-strip plane. A deflection apparatus is configured to deflect the light strip or the quasi-light strip, after the light strip or the quasi-light strip has passed through the illumination objective, in such a way that the light strip or the quasi-light strip propagates at an angle different from zero degrees with respect to an optical axis of the illumination objective. The illumination objective and the deflection apparatus are arranged movably relative to one another.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: September 26, 2017
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Werner Knebel, Frank Sieckmann, Bernd Widzgowski, Wernher Fouquet
  • Patent number: 9756317
    Abstract: The present invention discloses a holographic display apparatus including a light irradiating unit configured to irradiate light using an optical fiber array backlight, a spatial light modulator (SLM) configured to perform modulating the irradiated light, a lens configured to irradiate hologram images based on the modulated light, a pupil tracking unit configured to acquire location of an observer's pupil by pupil tracking, and a hologram generating unit configured to generate parallax hologram images that correspond to the location of pupil.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: September 5, 2017
    Assignee: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Hyun Eui Kim, Jin Woong Kim, Kyung Ae Moon, Min Sik Park
  • Patent number: 9752926
    Abstract: A scanning module including first path shifting unit changing a path of an incident electromagnetic wave from a light source; a first driving unit adjusting the path of the electromagnetic wave by moving the first path shifting unit; and a Bessel beam generating unit making a Bessel beam on a portion of an object, using the electromagnetic wave with the path changed by the path shifting unit. A detection probe which includes a light source generating an electromagnetic wave; a path shifting unit changing a path of an electromagnetic wave from a light source; a Bessel beam generating unit making a Bessel beam on a portion of an object, using the electromagnetic wave with the path changed by the path shifting unit; a detecting unit detecting intensity of a wave from the object, and a housing accommodating the light source, path shifting unit, Bessel beam generating unit, and detecting unit.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: September 5, 2017
    Assignee: Korea Food Research Institute
    Inventors: Sung Wook Choi, Hyun Jung Kim, Na Ri Lee, Hyun Joo Chang, Gyeong Sik Ok
  • Patent number: 9733124
    Abstract: A microplate reader includes a pair of linear variable filters (LVFs) that together form a wavelength selector. Movement of one or both of the LVFs enables selection of the desired center wavelength and/or passband used to analyze a sample on a microplate inserted into the microplate reader. The microplate reader may also include a similar second wavelength selector. The LVFs are located on movable frames, with each frame also advantageously including least one of an aperture, a fixed optical filter, and an optical polarization filter. In some cases, different types of measurements may be taken without changing the geometry of the optical path between the wavelength selectors. The microplate reader may additionally use a LVF to form a continuously adjustable dichroic for sample analysis.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: August 15, 2017
    Assignee: BMG LABTECH, GmbH
    Inventor: Markus Schappacher
  • Patent number: 9733462
    Abstract: A scanning apparatus includes a light source, a spatial light modulator that modulates an incident beam of light on a first reflection surface, an illumination lens that irradiates the spatial light modulator with a beam of light from the light source and that refracts a principal ray of a beam of light modulated by the spatial light modulator so that an angle between the principal ray and an optical axis of the illumination lens decreases, and a first reflector that directs, toward the illumination lens, a beam of light by reflecting the beam of light multiple times between the illumination lens and a front focal plane of the illumination lens, the beam of light being modulated by the spatial light modulator and entering through the illumination lens.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: August 15, 2017
    Assignee: OLYMPUS CORPORATION
    Inventor: Kentaro Yamazaki
  • Patent number: 9689797
    Abstract: The present invention discloses a microscopy imaging structure with phase conjugated mirror and the method thereof. The afore-mentioned imaging structure produces a reverse focusing conjugated probe beam together with an original probe beam. These two probe beams meet at the focal point in the object body to be probed, and an interference pattern is produced. The interval between any two consecutive wave fronts in the interference pattern is then half of the wavelength of the original probe beam, and hence the vertical resolution of the image is improved. The present invention also applies a light modulator module on the probe beam to easily adjust the depth of the focal point of the probe beam and the phase conjugated reverse focusing probe beam in the object body. With the adoption of this invention, the size or position limitation of the target object is eliminated and the imaging resolution is also improved.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: June 27, 2017
    Assignee: National Central University
    Inventors: Ching-Cherng Sun, Yeh-Wei Yu, Che-Chu Lin, Szu-Yu Chen
  • Patent number: 9625693
    Abstract: An object is to enable LSM observation while correcting aberrations, as well as illumination with a desired pattern, using a single LCOS.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: April 18, 2017
    Assignee: OLYMPUS CORPORATION
    Inventor: Susumu Honda
  • Patent number: 9620662
    Abstract: An ultraviolet sensor includes a silicon photodiode array having a plurality of first pixel regions and a plurality of second pixel regions. A filter film is disposed on each of the first pixel regions so as to cover each first pixel region, except on each second pixel region. The filter film lowers transmittance in a detection target wavelength range in the ultraviolet region. Each of each first pixel region and each second pixel region includes at least one pixel having an avalanche photodiode to operate in Geiger mode, and a quenching resistor connected in series to the avalanche photodiode. Each of the quenching resistors in the plurality of first pixel regions is connected through a first signal line to a first output terminal. Each of the quenching resistors in the plurality of second pixel regions is connected through a second signal line to a second output terminal.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: April 11, 2017
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Koei Yamamoto, Kenzo Hayatsu, Terumasa Nagano, Yuki Okuwa, Ryuta Yamada
  • Patent number: 9575300
    Abstract: The present invention relates to a confocal laser scanning microscope (100) having an illumination device (1) that comprises a laser light source (41) that is configured to illuminate a sample (25), and a control application circuit (40) for the laser light source (1) which is configured to output a pulsed control application signal (48) in order to supply the laser light source (41), the control application circuit (40) being configured so that it determines both a pulse amplitude (A) and a pulse width (W) of at least one pulse of the pulsed control application signal (48) as a function of at least one input variable (S).
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: February 21, 2017
    Assignee: Leica Microsystems CMS GmbH
    Inventor: Bernd Widzgowski
  • Patent number: 9563047
    Abstract: An optical system for digital microscopy having at least one lens, at least one telescope of the Kepler type and tube optics, wherein an aperture is arranged between the telescope and the tube optics, which aperture is imaged by means of the telescope at the rear focal point of the lens and the following conditions are met simultaneously: A light conductance value (L) of the lens is ?1.4, A light conductance value (L) of the telescope is ?0.35, A light conductance value (L) of the tube optics is ?0.35, wherein the equation for the light conductance value (L) is L=A(tan ?,) where A is the pupil diameter and ? is the angle of gradient of the pencil of light rays in infinite space, and wherein the microscope magnification (?) of the telescope is in the range ??????3.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: February 7, 2017
    Assignee: Carl Zeiss Microscopy GmbH
    Inventor: Rolf Wartmann
  • Patent number: 9523634
    Abstract: A sample holder comprises a bottom and one or more arms. The bottom has an initial area for supporting a sample. The one or more arms actuate to move the sample in the initial area to a target area, wherein the one or more arms hold the sample.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: December 20, 2016
    Assignee: TruTag Technologies, Inc.
    Inventors: Sergey Etchin, Timothy Learmonth, Michael P. O'Neill, Christopher Perrott, David Shepherd, Christopher Tacklind
  • Patent number: 9500848
    Abstract: A pattern irradiation apparatus includes a light source unit, an objective, a spatial light modulator, a light blocking member, and a control device. The objective irradiates a sample plane with light emitted from the light source unit. The spatial light modulator is of a phase modulation type and is arranged at a position conjugate with a pupil position of the objective and modulates a phase of the light emitted from the light source unit. The light blocking member is arranged in an optical path between the spatial light modulator and the objective and is configured to block 0-order light generated by the spatial light modulator. The control device makes a correspondence between a focusing position of the 0-order light generated by the spatial light modulator and a position of the light blocking member.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: November 22, 2016
    Assignee: OLYMPUS CORPORATION
    Inventor: Shintaro Fujii
  • Patent number: 9500847
    Abstract: A multiple wavelength total internal reflection fluorescence (TIRF) microscopy system has an objective. A dispersion unit of the system comprises a high-dispersion optical element. The dispersion unit receives illumination light having at least a first wavelength ?1 and a second wavelength ?2, where ?1??2, and splits the illumination light into a first monochromatic beam having the first wavelength ?1 and a second monochromatic beam having the second wavelength ?2. The monochromatic beams are focused onto a back focal plane of the objective, near an outer edge of the objective, at different radial distances from an optical axis of the objective. The dispersion unit is rotatable in order to adjust angles of incidence of the monochromatic beams onto an interface between a substrate and a sample to be imaged, wherein the angles of incidence are greater than the critical angle of the interface.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: November 22, 2016
    Assignee: Spectral Applied Research Inc.
    Inventors: Richard Berman, Peter Maclean Sinclair, John Oreopoulos
  • Patent number: 9494422
    Abstract: In order to make it possible for a difference between a defect and a normal part, such as contrast, to appear, a lighting device for inspection is provided with: a surface light source that emits inspection light; a lens that is provided on a light axis of the inspection light emitted from the surface light source, and between an inspection object and the surface light source; and a first diaphragm that is provided between the lens and the surface light source or the inspection object, wherein: the surface light source and the lens are set such that an image plane on which the surface light source is imaged is present near the inspection object; and the first diaphragm is set such that the central axis of an irradiation solid angle determined by a part of the inspection light is parallel to the light axis.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: November 15, 2016
    Assignee: CCS Inc.
    Inventor: Shigeki Masumura
  • Patent number: 9410880
    Abstract: The present invention belongs to a technical field of optical microscopic imaging and spectral measurement, and discloses a laser differential confocal mapping-spectrum microscopic imaging method and device. The core concept of the present invention is to combine the differential confocal detection and the spectrum detection techniques and use a dichroic beam splitting system (13) to separate the Rayleigh light for geometric position detection from the Raman scattering light for spectrum detection, by mean of the property that the zero-cross point of the differential confocal curve (43) accurately corresponds to the focus of the objective, the spectral information at focus of the excitation spot being accurately captured by the zero trigger to accomplish the spectrum detection with high spatial resolution. Therefore, the present invention provides a method and device that may be able to accomplish the spectrum detection with high spatial resolution to a micro-area of a sample.
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: August 9, 2016
    Assignee: BEIJING INSTITUTE OF TECHNOLOGY
    Inventors: Weiqian Zhao, Han Cui, Lirong Qiu, Yun Wang
  • Patent number: 9404869
    Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: August 2, 2016
    Assignee: Howard Hughes Medical Institute
    Inventor: Philipp Johannes Keller
  • Patent number: 9356413
    Abstract: Provided is a laser source apparatus including a single laser source that emits an ultrashort-pulse laser beam; a wavelength conversion mechanism that generates a plurality of pulsed laser beams having different wavelengths by converting at least a part of wavelength of the ultrashort-pulse laser beam; a dispersion adjusting section that adjusts the amount of frequency dispersion for each of the pulsed laser beams; and an introducing optics that emits the plurality of pulsed laser beams whose frequency dispersion amounts are adjusted by the dispersion adjusting section. The dispersion adjusting section adjusts the amount of frequency dispersion for each of the pulsed laser beams so that each of the pulsed laser beams introduced to the irradiation optics of the optical apparatus from the introducing optics to excite a specimen is close to a substantially Fourier-transform-limited pulse.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: May 31, 2016
    Assignee: OLYMPUS CORPORATION
    Inventor: Hirokazu Kubo
  • Patent number: 9332909
    Abstract: Provided is a fluoroscopy apparatus including a fluorescence-image generating portion that generates a fluorescence image; an identifying portion that identifies a position of a high-luminance region in the fluorescence image; a storage portion that stores the position of the high-luminance region; a detecting portion that detects an amount of change in a physical quantity, which can possibly act as a cause of changes in a property of the high-luminance region, starting from a time at which the position of the high-luminance region is identified by the identifying portion; a confidence-level calculating portion that calculates a confidence level of the property of the high-luminance region based on the detected amount of change; and a display-image generating portion that generates a display image in which the display mode at the position of the high-luminance region is set in accordance with the confidence level.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: May 10, 2016
    Assignee: OLYMPUS CORPORATION
    Inventors: Kei Kubo, Yasushige Ishihara, Hiromi Shida, Satoshi Takekoshi
  • Patent number: 9250430
    Abstract: A microscope adapter unit disposed on an optical path of illumination light between a light source unit including a light source and a sample surface includes a first lens group having at least one lens and a second lens group having at least one lens. The first lens group converts the illumination light into roughly parallel luminous fluxes, and makes the illumination light enter the second lens group.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: February 2, 2016
    Assignee: OLYMPUS CORPORATION
    Inventors: Masahito Dohi, Kenji Kawasaki, Kazuhiko Hosono