Abstract: A radiographic image capturing apparatus, comprising a plurality of sensors arrayed on a substrate, a driving unit, a detection unit and a control unit, wherein the control unit is configured to perform a first control controlling the driving unit so as to repeatedly initialize the plurality of sensors on a row-by-row basis before a start of emission of radiation, and a second control controlling the driving unit so as to interrupt the initialization in response to a detection signal from the detection unit and cause the plurality of sensors to output signals, and the apparatus further comprises a determination unit configured to determine whether or not the detection signal is a signal which was output in response to the start of emission of radiation.

Abstract: The present application discloses methods and systems for scanning an object. The scanning system provides a first detector region having a thickness of at least 2 mm and a second detector region having a thickness of at least 5 mm. The second detector region is arranged to receive radiation that has passed through the first detector region. The method includes irradiating the object with radiation having having a peak energy of at least 1 MeV, and detecting the first profile radiation after it has interacted with or passed through the object in order to provide information relating to the object.

Abstract: An X-ray imaging apparatus includes an X-ray generator configured to generate and emit X-rays, an X-ray detector configured to detect the X-rays and count a number of photons having energy equal to or greater than threshold energy per pixel among photons contained in the detected X-rays, a map generator configured to extract corrected threshold energy corresponding to target threshold energy mapped to each pixel, and a data correction unit configured to calculate corrected X-ray data corresponding to the corrected threshold energy per pixel from a plurality of X-ray data acquired based on a plurality of images of a target object obtained by using a plurality of approximate energies equal or approximate to the target threshold energy as threshold energy of the X-ray detector.

Abstract: An X-ray CT apparatus of an embodiment displays an image of the inside of an object based on projection data obtained by scanning the object, and comprises a generator, a converter, an image forming part and an identifier. The generator scans the object with each of X-rays of different energy levels and generates multiple projection data. The converter converts the multiple projection data into multiple new projection data corresponding to multiple reference substances. The image forming part reconstructs each of the multiple new projection data converted by the converter, thereby forming multiple reference substance images corresponding to the multiple reference substances. The identifier identifies a target substance based on a correlation of pixel values in the multiple reference substance images.

Abstract: Z-effective (e.g., atomic number) values are generated for one or more sets of voxels in a CT density image using sparse (measured) multi-energy projection data. Voxels in the CT density image are assigned a starting z-effective value, causing a CT z-effective image to be generated from the CT density image. The accuracy of the assigned z-effective values is tested by forward projecting the CT z-effective image to generate synthetic multi-energy projection data and comparing the synthetic multi-energy projection data to the sparse multi-energy projection data. When the measure of similarity between the synthetic data and the sparse data is low, the z-effective value assigned to one or more voxels is modified until the measure of similarity is above a specified threshold (e.g., with an associated confidence score), at which point the z-effective values substantially reflect the z-effective values that would be obtained using a (more expensive) dual-energy CT imaging modality.

Abstract: Imaging methods, apparatus and systems are provided for using different irradiation frequencies to generate a composite three-dimensional image. One exemplary method for imaging a semiconductor device involves irradiating the semiconductor device with a first frequency of electromagnetic radiation, obtaining a first radiation response from the semiconductor device in response to the first frequency of electromagnetic radiation, irradiating the semiconductor device with a second frequency of electromagnetic radiation, obtaining a second radiation response from the semiconductor device in response to the second frequency of electromagnetic radiation, and generating a composite image of the semiconductor device based at least in part on the first radiation response and the second radiation response.

Abstract: A radiation generating apparatus includes a cathode array including a plurality of electron emitting portions, and an anode array including a plurality of targets and a chained connection unit that connects the targets. The chained connection unit includes a plurality of shielding members and a thermal transfer member, the shielding members being arranged at locations corresponding to the locations of the respective targets, and the thermal transfer member having a thermal conductivity higher than a thermal conductivity of the shielding members. The thermal transfer member has a portion that is continuous in a direction in which the targets are arranged.

Abstract: A method for forming a three-dimensional reconstructed image acquires two dimensional measured radiographic projection images over a set of projection angles, wherein the measured projection image data is obtained from an energy resolving detector that distinguishes first and second energy bands. A volume reconstruction has image voxel values representative of the scanned object by back projection of the measured projection data. Volume reconstruction values are iteratively modified to generate an iterative reconstruction by repeating, for angles in the set of projection angles and for each of a plurality of pixels of the detector: generating a forward projection that includes calculating an x-ray spectral distribution at each volume voxel, calculating an error value by comparing the generated forward projection value with the corresponding measured projection image value, and adjusting one or more voxel values using the calculated error value and the x-ray spectral distribution.

Abstract: A system includes an energy-discriminating, photon-counting X-ray detector, comprising a plurality of detector cells adapted to produce projection data in response to X-ray photons and to produce an electrical signal having a recorded count for the energy bins and a total energy intensity. The system also includes data processing circuitry adapted to receive the electrical signal, to generate a simulated count rate for each of the energy bins by using the total energy intensity, to determine a set of energy intensity dependent material decomposition vectors, and, for the measured projection data, to perform material decomposition.

Abstract: Contour information is extracted from nuclear medicine projection data on a subject not subjected to a scattering correction and an absorption correction by performing a pixel value binarization processing based on a threshold scheme. If necessary, an interpolation processing is performed before reconstructing an image through an image reconstruction processing. Based on the reconstructed image, a second binarization processing is performed to generate a contour image.

Abstract: Provided is a medical imaging apparatus including: a scanner configured to obtain projection data of an object; a three-dimensional restoring module configured to restore a volume of the object based on the projection data; a volume segmentation module configured to segment a plurality of material volumes corresponding to a plurality of materials included in the object based on the volume of the object; a reprojection module configured to generate a plurality of reprojection images according to the plurality of materials by reprojecting the plurality of material volumes from a plurality of virtual viewpoints; and an image fusion module configured to generate a plurality of fusion images according to the plurality of virtual viewpoints, each of the plurality of fusion images being generated by fusing reprojection images according to plurality of materials obtained from the same virtual viewpoint.

Abstract: The present invention pertains to a system and method for adaptive X-ray filtration comprising a volume of X-ray attenuating material with a central less attenuating three-dimensional region. The volume of X-ray attenuating material can be positioned within 10 cm from an X-ray source and rotated around an internal axis of rotation. The volume of X-ray attenuating material can be symmetric around the internal axis while the central less attenuating region can be asymmetric around the internal axis. Rotating the volume by a predetermined angle around the internal axis can change the amount of attenuation of an X-ray beam through the filter. The volume can be rotated by the same predetermined angle as an imaging subject or X-ray source and detector are rotated during X-ray image acquisition.

Abstract: 3D reconstructions can be calculated from grayscale X-ray images taken at different angular positions of an X-ray source and detector rotatable about a common axis. In the present case, X-ray radiation is applied to the object to be imaged such that one half of the X-ray detector receives radiation which differs in one characteristic from the radiation received by the second half of the detector via the object. A kind of dual-energy imaging can then be carried out in a single pass through the angular positions, enabling two 3D reconstructions to be generated simultaneously and then merged.

Abstract: A photodetector according to an embodiment includes: a photodetector element unit including a first cell array including a plurality of first cells arranged in an array and a second cell array including a plurality of second cells arranged in an array, each of the first and second cells including a photoelectric conversion element, the second cell array being arranged to be adjacent to the first cell array; a first pulse height analyzer unit analyzing a pulse height of an electrical signal outputted from the first cell array; a second pulse height analyzer unit analyzing a pulse height of an electrical signal outputted from the second cell array; and a signal processing unit determining non-uniformity of a distribution of photons entering the first and second cell arrays using an output signal of the first pulse height analyzer unit and an output signal of the second pulse height analyzer unit.

Abstract: A medical imaging system has a radiation source, a radiation sensor, a data-collection unit, and an imaging system. The radiation source has an opening to direct a collimated radiation beam in a direction towards a patient. The radiation sensor is disposed proximate the opening and within the collimated radiation beam to measure a fluence of the collimated radiation beam. The data-collection unit is disposed to collect radiation from the collimated beam after interaction with the patient. The imaging system is in communication with the data-collection unit and configured to generate an image of a portion of the patient from the collected radiation.

Abstract: Photon counting detectors are sparsely placed at predetermined positions in the fourth-generation geometry around an object to be scanned in spectral Computer Tomography (CT). An X-ray emitting source rotates radially outside the sparsely placed photon counting detectors. Furthermore, the integrating detectors are placed in the third-generation in combination to the sparsely placed photon counting detectors at predetermined positions in the fourth-generation geometry.

Abstract: This specification is directed towards finding, locating, and confirming threat items and substances. The inspection system is designed to detect objects that are made from, but not limited to, special nuclear materials (“SNM”) and/or high atomic number materials. The system employs a dual energy CT scanning first stage inspection system and advanced image processing techniques to analyze images of an object under inspection (“OUI”), which includes, but is not limited to baggage, parcels, vehicles and cargo.

Abstract: Provided are an X-ray imaging apparatus that is capable of tracking a position of an object of interest using a Kalman filter so as to reduce the amount of X-ray radiation exposure of a subject, calculating covariance indicative of accuracy of the tracing, and controlling a collimator so that the position of the object of interest and calculated covariance may be correlated with a position and an area of a region into which X-rays are radiated, and a method of controlling the X-ray imaging apparatus.

Abstract: A method and system for producing tomosynthesis images of a breast specimen in a cabinet x-ray system. An X-ray source delivers X-rays through a specimen of excised tissue and forms an image at a digital X-ray detector. Multiple X-ray images are taken as the X-ray source moves relative to the stationary breast specimen. In the preferred embodiment, the X-ray source moves in a range from about 350° to and including about 10°. The source may travel substantially along a path that generally defines an arc, or linearly, while the detector remains stationary throughout and the source remains substantially equidistant from the specimen platform. The set of X-ray image data taken at the different points are combined to form a tomosynthesis image that can be viewed in different formats, alone or as an adjunct to conventional specimen radiography.

Abstract: A method for performing reconstruction for a region of interest (ROI) of an object is provided. The method includes designating the ROI within the object, the ROI being located within a scan field of view (FOV) of a combined third- and fourth-generation CT scanner, the CT scanner including fixed photon-counting detectors (PCDs), and an X-ray source that rotates about the object in synchronization with a rotating detector. Further, the method includes determining, for each PCD, as a function of view angle, an on/off timing schedule, based on a size and location of the designated ROI, and performing a scan to obtain a first data set from the rotating detector and a second data set from the plurality of PCDs, while turning each PCD on and off according to the determined schedule. Finally, the method includes performing reconstruction using the first and second data sets to obtain ROI spectral images.

Abstract: Multi-energy imaging is afforded with a single detector array by generating a first data set, indicative of a first radiation energy spectrum, using a first set of cells of the array, and by generating a second data set, indicative of a second radiation energy spectrum, using a second set of cells of the array (e.g., where substantially more cells are in the first set than the second). The first data set is comprised of measured data from the first set of cells and estimated data that would have been yielded from the second set of cells had the second set been configured to detect the first energy spectrum. The second data set is comprised of measured data yielded from the second set of cells and estimated data that would have been yielded from the first set of cells had the first set been configured to detect the second energy spectrum.

Abstract: A method and an X-ray system are disclosed for generating a phase contrast image of an examination object. In an embodiment, the distribution of an electron density in the examination object is determined by defining energy-dependent attenuation values for X-radiation with at least two different X-ray energy spectra, phase-shift values are obtained from the previously determined electron density distribution, and a phase contrast image is generated from the calculated phase-shift values.

Abstract: A method for detector angular response calibration in computed-tomography (CT) comprising capturing incident X-ray photons, emitted from an X-ray source, via a plurality of energy-discriminating detectors, determining photon counts of the captured incident X-ray photons in a plurality of energy windows at each energy-discriminating detector, and adjusting the photon counts based on a pre-determined detector angular response calibration look-up table for a given view for each energy-discriminating detector at each energy window.

Abstract: An imaging method performed by a device comprising an X-ray emitting source, a receiver positioned facing the source, and a support on which a subject or organ to be imaged is positioned, the method comprises defining a first set of orientations of the source and a second set of orientations of the source, and acquiring images at the defined orientations of the source, wherein it the first set of orientations comprises an orientation that the second set of orientations does not comprise, only one image is acquired at the orientation, and if both the first set of orientations and the second set of orientations comprise the same orientation, at least two images are acquired at distinct acquisition parameters at the orientation,

Abstract: A system and method for generating multi-energy computed tomography images of a subject using a polychromatic x-ray source with single spectrum includes acquiring a measure of a polychromatic spectrum of a polychromatic x-ray beam generated by the polychromatic x-ray source. The method also includes acquiring attenuation data generated by operating the polychromatic x-ray source, segmenting the attenuation data based on a plurality of component criteria to create plurality of segmented datasets, and generating template data from the segmented datasets. Using the template data and the measure of the polychromatic spectrum, polychromatic synthetic data is generated. Using the template data and each of the segmented datasets, component synthetic data is generated. Using the attenuation data, the polychromatic synthetic data, and the component synthetic data, a plurality of multi-energy images, including separable images weighted for each of the component criteria, is reconstructed.

Abstract: Described here are systems and methods for generating x-ray phase contrast images from conventional x-ray attenuation data. X-ray attenuation coefficients generated over a range of x-ray energies are used to compute the x-ray phase signal up to a calibration constant. This calibration constant is computed from provided calibration data, which may be obtained using a dedicated x-ray differential phase contrast imaging system to measure the decrement of the refractive index of a calibration phantom.

Abstract: Embodiments of methods and apparatus are disclosed for obtaining a phase-contrast digital radiographic imaging system and methods for same that can include an x-ray source for radiographic imaging; a beam shaping assembly including a collimator and a source grating, an x-ray grating interferometer including a phase grating, and an analyzer grating; and an x-ray detector, where a single arrangement of the beam shaping assembly, the x-ray grating interferometer and a position of the detector is configured to provide spectral information (e.g. at least two images obtained at different relative beam energies).

Abstract: A system includes a detector and a processing unit. The detector includes multiple pixels configured to detect computed tomography (CT) events and nuclear medicine (NM) imaging events. The CT events correspond to X-rays emitted from a X-ray source through an object to be imaged, and the NM imaging events correspond to gamma rays emitted from a radiopharmaceutical that has been administered to the object. The detector is configured for photon counting detection of the CT events and the NM imaging events. The processing unit includes at least one processor and at least one memory comprising a tangible and non-transitory computer readable storage medium. The processing unit is configured to, based on corresponding energy levels of the CT events and the NM imaging events, identify CT information corresponding to the CT events and identify NM information corresponding to the NM imaging events.

Abstract: A method for dual-energy spectra CT scanning and image reconstruction of two tomographic image datasets from a higher-energy and a lower-energy x-ray energy spectrum is disclosed. In at least one embodiment, readings are taken with the different x-ray energy spectra during the scanning; the different x-ray energy spectra are also created at least by different acceleration voltages of the x-ray source; and the spatial distribution of the scanning x-rays per x-ray energy spectrum is undertaken randomly or pseudo-randomly (in the absence of a regular pattern). With the attenuation datasets thus obtained, reconstructions of two tomographic image datasets in accordance with a least one iterative CS reconstruction method are carried out and subsequently the reconstructed tomographic image datasets are stored and/or output and/or further processed.

Abstract: An imaging system (600) includes a radiation source (608) that emits polychromatic radiation that traverses an examination region and a detector array (610) located opposite the radiation source, across the examination region, which includes a paralyzable photon counting detector pixel (611) that detects photons of the radiation that traverse the examination region and illuminate the detector pixel and that generates a signal indicative of each detected photon. An output photon count rate to input photon count rate map (626) includes at least one map which maps multiple input photon count rates of the detector pixel to a single output photon count rate of the detector pixel, and an input photon count rate determiner (624) identifies one input photon count rate of the multiple input photon count rates of the map as a correct input photon count rate for the detector pixel. A reconstructor that reconstructs the signal based on the identified input photon count rate.

Abstract: Based on a plurality of detection data sets acquired by a data acquisition unit and correspond to respective tube voltages, an image generator generates a plurality of reference substance image data sets targeting respective reference substances contained in a subject. The image generator generates a correction data set for each of the plurality of tube voltages by applying, to a detection data set corresponding to each of the tube voltages, a correction coefficient for suppressing a discrepancy of an actual energy spectrum of the X-rays detected by an X-ray detector from a predetermined X-ray energy spectrum, and generates the plurality of reference substance image data sets based on a plurality of correction data sets corresponding to the respective tube voltages.

Abstract: Disclosed herein are an X-ray imaging apparatus and a method for controlling the same. The X-ray imaging apparatus includes an X-ray generator configured to radiate first-energy X-rays toward an object, an X-ray detector configured to detect the first-energy X-rays which propagate through the object, an image processor configured to generate a first object image which correspond to the detected first-energy X-rays and to estimate a second object image which corresponds to second-energy X-rays based on the generated first object image, and a controller configured to control the image processor to repeatedly estimate the second object image by controlling the X-ray generator to repeatedly radiate the first-energy X-rays toward the object.

Abstract: In a control method and a control unit to control a high-energy, tomosynthesis scan in a contrast agent-assisted dual-energy tomosynthesis, image data of a first tomosynthesis scan are evaluated in order to determine the respective greyscale values for all volume segments. A tube current-time product value for every greyscale value is stored in a memory. For every projection angle, a calculation unit can thereupon calculate a tube current-time product value and acquisition parameters and result with which the second high-energy tomosynthesis scan is controlled.

Abstract: A buffer on detector elements of an X-ray radiation detector can be used, when acquiring a number of 2D X-ray image data records with the aid of an X-ray angiography system, to acquire 2D image data records at a relatively short interval one after the other with the aid of different X-ray spectra, to allow dual-energy imaging, which may be of particularly good quality.

Abstract: A method of evaluating a reservoir includes a multi-energy X-ray CT scan of a sample, obtaining bulk density and photoelectric effect index effect for the sample, estimation of at least mineral property using data obtained from at least one of a core gamma scan, a spectral gamma ray scan, an X-ray fluorescence (XRF) analysis, or an X-ray diffraction (XRD) analysis of the sample, and determination of at least one sample property by combining the bulk density, photoelectric effect index, and the at least one mineral property (e.g., total clay content). Reservoir properties, such as one or more of formation brittleness, porosity, organic material content, and permeability, can be determined by the method without need of detailed lab physical measurements or destruction of the sample. A system for evaluating a reservoir also is provided.

Abstract: An IGRT system and methods are described embodiments of which perform selectively integration of x-ray source arrays, dual-energy imaging, stereoscopic imaging, static and source collimation, or inverse geometry tomosynthesis imaging to acquire or track a target during radiation treatment.

Abstract: The present invention provides a multi-view X-ray inspection system. In one embodiment, a beam steering mechanism directs the electron beam from an X-ray source to multiple production targets which generate X-rays for scanning which are subsequently detected by a plurality of detectors to produce multiple image slices (views). The system is adapted for use in CT systems. In one embodiment of a CT system, an electron beam generated by a single radiation source is steered by an electron beam transport mechanism comprising at least two dipoles and a quadrupole on to a target arranged in an approximated arc. The inspection system, in any configuration, can be deployed inside a vehicle for use as a mobile detection system.

Abstract: A method of analyzing a target item utilizing multiple scanners is disclosed. The method can include providing an item comprising a material. The method can further include acquiring a first set of scan data associated with the item using a first scanner, and acquiring a second set of scan data associated with the item using a second scanner. The method can further include generating a first set of transform data from the first set of scan data, analyzing the first set of transform data to identify a subset of the first set of transform data associated with a first region, and analyzing the second set of scan data to identify a subset of the second set of scan data associated with a second region.

Abstract: The present technology relates generally to systems for characterizing atherosclerotic plaque, such as a spectral CT system, and methods of using same.

Abstract: An apparatus and method for dynamically calibrating a computed-tomography (CT) scanner that includes a rotating X-ray source and a plurality of stationary energy-discriminating detectors configured to capture incident X-ray photons emitted from the X-ray source. A bowtie filter with a unique geometry and material composition is used to generate reference beams of a desired intensity. The apparatus includes a processor that is configured to remove a scattering background based on data obtained from the reference beams and compute a change in a predetermined calibration function.

Abstract: Disclosed is a CT imaging method and system. The method includes: CT scanning an object with a dual-energy CT system to obtain a first complete set of projection data in a first scan mode, and to obtain a second incomplete set of projection data in a second scan mode; reconstructing a first attenuation coefficient image of the object from the first set of projection data, and extracting, from the first attenuation coefficient image, prior structure information of the object indicating edge intensity; and reconstructing a second attenuation coefficient image of the object from the second incomplete set of projection data using the extracted prior structure information as a constraint. With the method using the prior structure information of the imaged object as a constraint in reconstruction, it is possible to dramatically reduce an amount of data required for reconstruction, and achieve satisfactory effects even with ill-conditioned problems of limited-angle and inner reconstruction.

Abstract: An imaging system includes a rotatable gantry for receiving an object to be scanned, a generator configured to energize an x-ray source to generate x-rays, a detector positioned to receive the x-rays that pass through the object, and a computer. The computer is programmed to obtain knowledge of a metal within the object, scan the object using system scanning parameters, reconstruct an image of the object using a reconstruction algorithm, and automatically select at least one of the system scanning parameters and the reconstruction algorithm based on the obtained knowledge.

Abstract: An apparatus and method for dynamically calibrating a computed-tomography (CT) scanner that includes a rotating X-ray source and a plurality of stationary energy-discriminating detectors configured to capture incident X-ray photons emitted from the X-ray source. A bowtie filter with a unique geometry and material composition is used to generate reference beams of a desired intensity. The apparatus includes a processor that is configured to remove a scattering background based on data obtained from the reference beams and compute a change in a predetermined calibration function.

Abstract: An X-ray CT apparatus includes an image generating unit, a discrimination unit, a monochromatic X-ray image generating unit, a combined-image generating unit and a display unit. The image generating unit generates a plurality of reference material images corresponding to respective ones of a plurality of reference materials on a basis of pre-reconstruction data of multi-energy obtained by scanning a subject. The discrimination unit discriminates each of a plurality of materials contained in an imaging region of the subject on a basis of the plurality of reference material images. The monochromatic X-ray image generating unit generates a monochromatic X-ray image at energy determined by each of the plurality of discriminated materials. The combined-image generating unit combines a plurality of monochromatic X-ray images corresponding to the plurality of materials and to generate a combined image. The display unit displays the combined image on a display device.

Abstract: A method for controlling the emission of an X-ray imaging device configured to take images of a patient's body, into which a medical instrument has been inserted, is provided. The method comprises: processing at least one image of the patient's body taken by the X-ray imaging device to extract information representing the instrument, wherein the at least one image comprises the instrument; and adapting X-ray emission parameters of the X-ray imaging device, depending on the information extracted from the at least one image, to minimize the X-ray dose emitted towards the patient's body.

Abstract: A method of estimating chordal holdup values of gas, oil, and water (?G, ?O, ?W) for tomographic imaging of a three-phase flow through a volume, including: providing an X-ray source for irradiating through said volume and X-ray sensors for discriminating between a first and a second radiation bands, conducting first calibration measurements (IGS, IOS, IWS) of said first radiation band, conducting second calibration measurements (IGH, IOH, IWH) of said second radiation band, arranging a mixture of two or more fluids, irradiating said volume and conducting X-ray measurements (IS, IH) in said radiation bands, establishing a relationship between a function of holdup values f(?G, ?W) of at least gas and water and said X-ray measurements (IS, IH), searching holdup values (?G, ?W) that minimise said function of holdup values f(?G, ?W) under the constraints of the sum of said holdup values is more than or equal to zero and less than or equal to one, i.e. that 0??G+?W?1.

Abstract: A method and a system are disclosed for obtaining image data from inside an examination object from images of a computed tomograph. In an embodiment, the method includes accepting first measurement data of the examination object, acquired based on x-ray radiation of a first energy, and second measurement data of the examination object, acquired based on x-ray radiation of a second energy differing from the first energy; setting an optimized output of target image points on the basis of the first and second measurement data at the respective target image points, each as a function of local optimization parameter values of the target image points determined locally from the first and second measurement data in the area of the target image points, while deriving image point reproduction parameter values representing the optimized output; and determining the output data based on optimized output of the target image points.

Abstract: Methods and systems for active resonant voltage switching are provided. One active resonant switching system includes a voltage switching system having one or more active resonant modules to provide a switching voltage output. Each of the resonant modules includes a plurality of switching devices configured to operate in open and closed states to produce first and second voltage level outputs from a voltage input. The resonant modules also include a capacitor connected to the switching devices and configured to receive a discharge energy during a resonant operating cycle when switching an output voltage from the first voltage level to the second voltage level, wherein the capacitor is further configured to restore system energy when switching from the second to first voltage level. The resonant modules further include a resonant inductor configured to transfer energy to and from the capacitor.

Abstract: Systems and methods are provided for staining tissue with multiple biologically specific heavy metal stains and then performing X-ray imaging, either in projection or tomography modes, using either a plurality of illumination energies or an energy sensitive detection scheme. The resulting energy-weighted measurements can then be used to decompose the resulting images into quantitative images of the distribution of stains. The decomposed images may be false-colored and recombined to make virtual X-ray histology images. The techniques thereby allow for effective differentiation between two or more X-ray dyes, which had previously been unattainable in 3D imaging, particularly 3D imaging of features at the micron resolution scale. While techniques are described in certain example implementations, such as with microtomography, the techniques are scalable to larger fields of view, allowing for use in 3D color, X-ray virtual histology of pathology specimens.

Abstract: A method for estimating effective atomic number and bulk density of objects, such as rock samples or well cores, using X-ray computed tomographic imaging techniques is provided. The method effectively compensates for errors in the interpretation of CT scan data and produces bulk densities which have lower residual error compared to actual bulk densities and produces bulk density—effective atomic number trends which are consistent with physical observations.