Abstract: The present invention concerns methods, compositions and apparatus for neutralizing bioagents, wherein bioagents comprise biowarfare agents, biohazardous agents, biological agents and/or infectious agents. The methods comprise exposing the bioagent to an organic semiconductor and exposing the bioagent and organic semiconductor to a source of energy. Although any source of energy is contemplated, in some embodiments the energy comprises visible light, ultraviolet, infrared, radiofrequency, microwave, laser radiation, pulsed corona discharge or electron beam radiation. Exemplary organic semiconductors include DAT and DALM. In certain embodiments, the organic semiconductor may be attached to one or more binding moieties, such as an antibody, antibody fragment, or nucleic acid ligand. Preferably, the binding moiety has a binding affinity for one or more bioagents to be neutralized. Other embodiments concern an apparatus comprising an organic semiconductor and an energy source.

Abstract: A hydratable gel-forming polymer may be sterilized by chilling the polymer below ambient temperature and sterilizing the chilled polymer using ionizing radiation (e.g., E-Beam radiation). Doing so may reduce the degradation in physical properties caused by ionizing radiation sterilization of the polymer while at ambient temperature, and may preserve or retain desired hydration or gel-forming characteristics.

Abstract: An arrangement for the exposure of a pumpable medium to an electric field. The arrangement comprises, at least two power supplies (100) for the generation of electrical voltage, at least one non-conducting chamber (102) for pumping said pumpable medium, which said at least one chamber (102) is provided with a first (106) and a second electrode plate (108), a control means (104) for controlling said at least two power supplies (100). During control the control means (104), by synchronous control, establishes a series connection between at least two of said at least two power supplies (100), the first electrode plate (106) and the second electrode plate (108). A resulting composite voltage arises between the first (106) and the second electrode plate (108), which resulting composite voltage will result in an electric field between the first (106) and the second electrode plate (108). The pumpable medium is exposed to the electric field.

Abstract: This invention provides a process of sterilizing a medical device, and preferably the contents of a sealed container which comprises said medical device, comprising the step of exposing said medical device to monochromatic ultraviolet radiation whereby the Dvalue of Bacillus stearothermophilus (ATCC 7953) is at least 23.7 mJ/cm2 monochromatic ultraviolet radiation at 257 nm to the spore. Further, this invention provides a process of sterilizing a medical device comprising the step of subjecting said medical device to monochromatic ultraviolet radiation wherein the minimum total energy density of said monochromatic ultraviolet radiation at 257 nm which reaches the microorganisms present on said medical device is at least 284 mJ/cm2. This invention further provides an apparatus for delivering UV radiation to a medical device for sterilization comprising a laser and a scanner for the laser such that at least 284 mJ/cm2 at 257 nm is applied to a treatment area for said medical device.

Abstract: The invention relates to a device for treating formed parts with high-energy electron beams. The electron beams are guided by two opposite stationary or displaceable electron discharge windows onto the formed part and bounding a process space for the formed part. A transport device is present for the formed part, by which the formed part can be guided through the process space to the electron discharge windows disposed substantially vertically perpendicular to the transport direction. A channel is disposed in the process space for transporting the formed part and largely shielded against the X-ray radiation.

Abstract: Apparatus for providing activated treated water to washing machines with a water treatment conduit connected between a water supply and an inlet of the washing machine, having a reactor chamber with a UV lamp and a coated metal target that generates oxidizing gases that communicate by an injector into the conduit and a transparent portion of the conduit treats the oxidated water by illumination from the UV lamp. A disinfector injects disinfecting silver ions into the treated oxidated water. A controller activates the apparatus during flow of water through the conduit. A method of activating and treating water for washing machines is disclosed.

Abstract: A method of manufacturing a hood for use with a personal protection system. The hood includes a shell formed from at least partially out of a filter medium. At least one transparent layer is initially attached to a transparent face shield. The transparent layer-face shield assembly is sterilized with gamma radiation and attached to the shell to form the hood. The hood is then sterilized with ethylene oxide.

Abstract: An Ultraviolet-C (UVC) based portable water purification system employing a novel array of baffles increases the efficiency per unit energy of irradiating UVC light in the eradication of pathogens in the water. Closed loop feedback allows monitoring the application of UVC light power to ensure high levels of pathogen eradication. This system is capable of eradicating a wide range of waterborne bacteria, viruses, protozoa, helminthes, yeast, and mold found in natural freshwater sources worldwide. By adding pre- or post-filters, the system can remove harmful organic compounds, pesticides, inorganic compounds and heavy metals from the water. The system can also be used to eradicate pathogens in fluids other than water. As a feature of this invention, a communications systems that can reach geographically dispersed populations at low cost without the need to install costly wired communications infrastructure is combined with and powered by the water purification system.

Abstract: The invention relates to a process for producing an (ultra) high molecular weight polyethylene (HMWPE) article comprising:—incorporating into the HMWPE resin a Hindered Amine Light Stabilizer (HALS) and—cross-link the (U)HMWPE during or after molding the (U)HMWPE resin.

Abstract: Terminally sterilized collagen that is soluble at a neutral pH is useful for medical uses. The invention also relates to the method for preparing such terminally sterilized collagen.

Abstract: A method and device related to a liquid product pressure and (optionally) temperature treatment method reduces the level of microorganisms in the liquid product to a preselected level. Utilizing the method, liquid product is diffused in a chamber with the speed of pressure variation of liquid product in one embodiment of about 109 Pa/sec. The preferred speed of the diffused drops is about 10 m/sec. The liquid product can optionally be heated before or during diffusion, and is preferably heated as a diffused liquid product by mixing it with superheated steam. The device includes a chamber and a diffuser in communication with the chamber.

Abstract: A process for decontamination by radiation of a product. The process comprises at least one exposing step during which at least a first part of the product is exposed to a first radiation level, and at least a second part of the product is exposed to a second radiation level. The invention also relates to an equipment suitable for such a process.

Abstract: This invention discloses the treatment of effluents in which a flow of the said effluents is subjected to a pulsed electric field that modifies physicochemical and biologic characteristics of the medium, this modification being used during a solid/liquid separation operation, of the settlement or membrane filtration type. The solid/liquid separation operation (13, 14, 15) and the application of a pulsed electric field (12) are operations carried out at different locations along the effluent flow. The pulsed electric field has voltage value, current value, pulse repetition frequency and voltage front shape characteristics chosen such that the required effluent treatment can be achieved as a function of the locations at which these membrane filtration operations are carried out and a pulsed electric field is applied.

Abstract: The invention relates to a method for sterilizing a film container for holding articles, foods, cosmetics, medical implants, medical plasters, medical auxiliaries, microbiological tools or a pharmaceutical active substance formulation, a method for testing the leaktightness of a film container sterilized by electron radiation or gamma radiation, and a film container for use in the methods.

Abstract: The removal of moisture from an object to be sterilized is provided through at least the steps of placing the load in the chamber, reducing the pressure within the chamber to increase the rate of evaporation of moisture from the load, monitoring over a predetermined period of time the increase in the quantity of vapor within the chamber resulting from evaporation of moisture from the load, admitting gas into the chamber and repeating the steps following placing the load into the chamber.

Abstract: The present invention relates to a method of utilizing ultrasonic waves emitted into a fluid to treat the fluid, matter within the fluid, and/or organisms within the fluid in a variety of manners such as, but not limited to, cleaning objects within the fluid, sterilizing the fluid and/or objects within it, separating bonded matter within the fluid, segregating matter within the fluid into discrete laminas, killing organisms within the fluid, inactivating organisms within the fluid, extracting matter from organisms within the fluid, extracting matter from other matter within the fluid, inducing chemical reactions within the fluid, and/or converting toxic matter within the fluid into a less toxic state.

Abstract: Photodynamic therapy is used in the treatment of orthopaedic infections. Particularly, it is used in the treatment of infections related to orthopaedic conditions and surgery and includes treatment of sites of deterioration or trauma, such as prior to and after prosthetic fixation such as joint replacement or treatment of trauma sites such as pinning of bone fractures. An orthopaedic disinfection apparatus includes a photosensitiser and a light delivery system capable of producing and delivering light at a wavelength which is capable of being absorbed by the photosensitiser. Methods of treatment of orthopaedic infections are also disclosed.

Abstract: This invention relates to a plasma surface modification process (and a corresponding a system) of a solid object (100) comprising creating plasma (104) by a plasma source (106), application of the plasma (104) to at least a part of a surface (314) of the solid object (100), generating ultrasonic high intensity and high power acoustic waves (102) by at least one ultrasonic high intensity and high power acoustic wave generator (101), wherein the ultrasonic acoustic waves are directed to propagate towards said surface (314) of the object (100) so that a laminar boundary layer (313) of a gas or a mixture of gases (500) flow in contact with said solid object (100) is thinned or destructed for at least a part of said surface (314). In this way, the plasma can more efficiently access and influence the surface of the solid object to be treated by the plasma, which speeds the process time up significantly.

Abstract: A device for disinfecting components of an air conditioning system in a motor vehicle is provided. The device includes an ionizer arranged in the air conditioning system and an electronic control unit configured to activate the ionizer to produce an amount of ions. The amount of ions is determined as a function of an amount of condensate on the components of the air conditioning system to be disinfected.

Abstract: There is disclosed an ultraviolet radiation device. The device comprises a base portion, a plurality of semiconductor structures connected to the base portion and an ultraviolet radiation transparent element connected to the plurality of semiconductor structures. Preferably: (i) the at least one light emitting diode is in direct contact with the ultraviolet radiation transparent element, or (ii) there is a spacing between the at least one light emitting diode and the ultraviolet radiation transparent element, the spacing being substantially completely free of air. There is also disclosed a fluid treatment system incorporating the ultraviolet radiation device.

Abstract: The present invention relates to methods for sterilization of dispersions of one or more nanoparticulate active agents via gamma irradiation.

Abstract: A sterilisation process comprising the heating of liquid by waves of electric field having a frequency greater than 1 MHz, at a speed greater than 28° C. per second, to a treatment temperature T between 20° C. and 66° C., and according to the value of the treatment temperature T, exposure of the liquid to an alternating electric field in pulses immediately or slightly after heating of the liquid.

Abstract: The present invention relates to methods of sanitizing structures, buildings, passenger occupiable vehicles, and other enclosed or enclosable spaces. More particularly, the present invention relates to a method for killing and/or removing pests and their allergens, bacteria, viruses, fungi, molds, volatile organic compounds and other dangerous substances, from such enclosures.

Abstract: A method and a series of devices for dry cleaning, activating, modifying, coating, and biologically decontaminating (degerming, disinfecting, sterilizing) surfaces by means of an atmospheric pressure plasma generated using a surface barrier discharge are provided. The invention is used for dry cleaning, activating, coating, modifying, and biologically contaminating surfaces by means of an atmospheric pressure plasma generated in a defined, flowing gas atmosphere by a surface barrier discharge, comprising a high-voltage electrode that is covered with a dielectric or ferroelectric material, an electrically conducting grounded contact electrode, a high-voltage supply, a gas supply, and a gas nozzle (encompassing a gas outlet); said gas nozzle is located in the direct vicinity of the grounded contact electrode, is integrated into the contact electrode, or acts as the grounded contact electrode.

Abstract: The present invention relates to sterilization of medical devices having hydrophilic coatings and more specific to sterilization of medical devices having a wetted hydrophilic coating using radiation. The medical devices sterilized according to the invention show, after sterilization using radiation, a prolonged water drain off time and reduced friction force.

Abstract: An apparatus for sterile filling of beverage containers has a first module and a second module. The first module rinses and sterilizes empty containers and delivers the sterilized containers to the second module. The second module fills and caps the containers with beverage product at ambient temperature in an active sterilization zone utilizing an e-beam sterilization unit.

Abstract: A sterile device immersed in a sterile buffer and a method for providing same. The sterile device may be a medical device such as a biosensor having a biomolecule as a sensing element such as, for example, a glucose oxidase enzyme. The buffer may be a bicarbonate solution. Both the device and the buffer may be packaged and stored over long term while maintaining sterilization. The sterilization method may comprise a combination of gaseous, liquid and light sterilization.

Abstract: A polymeric composition resistant to degradation by exposure to gamma radiation comprising PVDF and between 1 and 20% by weight HDPE based on the total weight of the polymeric composition.

Abstract: An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation characteristics of the apparatus to be calibrated. A control circuit uses the measurements to control the delivery of an effective dose of illumination to blood or blood products in a bag or container. One or more light integrating optical chambers in the radiometer allow a single light sensor to sense light across an entire field. Thermistors in the irradiating apparatus or the radiometer or both sense the temperature of photo sensors. The control circuit compensates for temperature-dependant variations in the output of the photo sensors.

Abstract: The invention refers to a method consisting of treating food through the application of low-frequency waves in resonance with each pathogen, said waves being non-ionizing radiations, which differ from dangerous high-frequency waves, which are ionizing. This invention enables to obtain food without microbial contamination and without applying regular aggressive treatments. With this treatment a reduction of microbial contamination levels in food is obtained, acting on all kinds of microorganisms, both aerobic and anaerobic ones.

Abstract: A variety of article and systems including wound care systems, methods for making the wound care systems, bactericidal, and methods for treating wounds using these systems are disclosed. The wound care systems may include a first material comprising one or more fibers or porous media. The one or more fibers or porous media may be coated with a second material that is capable of inhibiting the growth of bacteria and killing the bacteria to render the wound care system sterile, increasing the absorbency of the first material, or both upon exposure to light. The first material may be cotton, or any suitable fibrous material, the second material may be TiO2, and the light may be UV or visible light. A variety of methods including ALD may be used to coat the first material.

Abstract: The disclosed technology relates to a genetically engineered biological indicator, comprising: at least one test organism and at least one reporter gene suitable for producing an indicator enzyme, the reporter gene being taken up by the test organism; and at least one repressor gene that inhibits expression of the reporter gene until the reporter gene is exposed to at least one inducer. A process and an apparatus for using the biological indicator are disclosed.

Abstract: Disclosed herein are methodologies and compositions for coating materials, which can be used in a variety of biological applications.

Abstract: The present invention relates to methods for sterilization of dispersions of one or more nanoparticulate active agents via gamma irradiation.

Abstract: An in vitro testing process for simulating conditions of a stomach, comprising, in combination: providing an intragastric device to an acetone bath; inducing swelling of the intragastric device; exacerbating weak spots in the intragastric device; observing the results; and estimating the results of an in vivo study. Improvements to an intragastric space filler to reduce failure at a balloon to shaft area including an adhesive fillet, washers, a balloon cuff and collar, a molded in balloon fillet, and a one-piece molded balloon assembly.

Abstract: The current invention provides this advance in infection control via its unique application of active sterilization to a catheter or implant. While most catheters, and many implants, are passive devices, the current invention will provide an active component as a integral part of the implanted catheter or device to continuously or intermittently sterilize the exposed surfaces/areas of the device. This active sterilization may be accomplished by a variety of mechanisms, including, application of heat, RF, microwave, ultrasound, ultraviolet radiation or other energy capable of sterilizing the device or dislodging any problematic Biofilm that may form. The active sterilization may also employ the pumping of a sterilizing chemical from an attached drug reservoir, the use of electricity or freezing temperatures or any other mechanism for either inhibiting, killing or dislodging any infectious material in contact with the implant.

Abstract: An electron beam emitter including a vacuum chamber having a width. An electron generator can be positioned within the vacuum chamber for generating electrons. An elongate nozzle can extend from the vacuum chamber along a longitudinal axis and have an exit window at a distal end of the nozzle. The nozzle can have a width that is less than the width of the vacuum chamber. The electron generator can be shaped and dimensioned, and positioned with the vacuum chamber to form and direct a narrow electron beam that enters and travels through the nozzle, and exits out the exit window.

Abstract: Disclosed are methods of inhibiting, avoiding or destroying existing, potential or incipient biodeposits, biofilms or pathogens any of (a) in or on a living body including in or on a medical device or implement placed, inserted or insertable in the body, (b) in, on or in contact with an ex vivo bodily tissue or fluid, or (c) in, on or in contact with a medium or matter to be consumed, ingested by or exposed to a living being or entity. Also disclosed are medical devices, implements, and prostheses that can be kept in a safe defouled, pathogen-free or pathogen-reduced condition with the help of an electric field(s). Also disclosed are medical or industrial devices, implements, equipment-articles and storage/handling-entities that can be kept in a safely defouled, pathogen-free or pathogen-reduced condition with the help of a membrane or orifice that has one or more of the antifouling or antipathogenic attributes.

Abstract: The present invention includes a composition for enhancing the antimicrobial efficacy of photodynamic disinfection against Gram-negative organism that is receptive to paraben potentiation using a composition comprising a photosensitizer and at least one paraben. The present invention also includes a method for photodynamic disinfection comprising applying the composition to a desired treatment area and applying light to the desired treatment area at a wavelength absorbed by the photosensitizer so as to inhibit Gram-negative organism located within the treatment area wherein the Gram-negative organism is receptive to paraben potentiation.

Abstract: The present invention overcomes the difficulties in the sterilization and delivery of viscous, multi-component compositions that require pre-mixing prior to usage by disclosing a sterile, multi-component, ready-to-use product wherein each component is sterilized independently and then assembled into a sterilized delivery kit. In certain preferred embodiments of the present invention, a sterile, polymerizable system is provided that comprises a plurality of sterile polymerizable monomers, said monomers having been sterilized by passing them through a filter; at least one sterile filler which has been exposed to conditions effective to render said filler sterile, and the sterile monomers and the sterile filler being blended together to form at least one substantially homogeneous blend contained within a sterile delivery vessel.

Abstract: A device for disinfecting publicly-used equipment includes a plurality of reflective units disposed along the interior of each wall of the device. Each of the reflective units can include a reflective back section and at least three reflective sections disposed about the reflective back section. UV lamps can be disposed to extend along the walls, and at partially disposed adjacent to a one or more reflective back sections of the reflective units. The UV lamps together with the reflective units collectively direct sufficient UV light on the equipment such that the equipment can be disinfected. The walls and ceiling of the device define a tunnel into which the equipment to be disinfected is inserted. Optionally, the device can include a door to prevent children and others from entering the tunnel while the UV lamps are illuminated.

Abstract: Method for preparing a medical solution, comprising the steps of a) providing a solution comprising one or more acetylated or deacetylated amino sugar/sugars in at least one compartment of a container at a pH from 2.5 to 5.0, and b) terminal sterilization of said at least one compartment and the contents therein, is disclosed, as well as a solution used for preparing the medical solution, a container containing said solution, and use of said solution for the manufacture of a medicament for peritoneal dialysis.

Abstract: The viscosity of 2-cyanoacrylate monomer based adhesives is increased by combining the monomers with suitable thickeners according to a certain process. The resulting formulations may be heat sterilized without degrading the viscosity or causing premature polymerization. The effectiveness of the sterilization process is assayed by disposing bacterial spores in the formulation, exposing it to a dry heat sterilization process, transferring it to a sterile aldose solution, transferring and exposing the sample to a nutrient medium which supports germination and growth of viable spores, incubating the samples, and determining the presence or absence of growth.

Abstract: Disclosed are an apparatus and a method for sterilizing a food product. The apparatus comprises an ionization unit for holding the food product, a housing enclosing the ionization unit, a bipolar ionization assembly and a pulse power energization assembly. The bipolar ionization assembly comprises a generator unit and at least one ionization tube for generating bipolar ionization within the ionization unit for sterilizing the food product. The pulse power energization assembly comprises at least one ultraviolet light energy source for generating pulsed energy and at least one ultraviolet light emitting unit for generating pulsed ultraviolet light within the ionization unit upon receiving the pulsed energy. The pulsed ultraviolet light is capable of irradiating the food product for sterilizing purposes.

Abstract: A method of preserving a biomaterial according to the present invention includes the step of simultaneously applying negative DC voltage and AC voltage to a biomaterial (O). It is preferable that in the simultaneous voltage application step, the biomaterial (O) is stored in a container (1) that surrounds at least the periphery of the biomaterial (O), and a voltage application plate (2) supplied with negative DC voltage and AC voltage in a superposed manner is placed along one outer surface of the container (1), so that the voltage is indirectly applied to the biomaterial (O).

Abstract: A sterilization system for PET containers and bottles including at least one electron flow generator 1, a scan gun 2 and at least one target 4 preferably made of heavy metal, so that when a part of the electron radiation hits said target a reflected X ray radiation is generated, which contributes to the sterilization of the containers. A certain amount of liquid or gaseous oxygen which upon collision with the electron radiation is converted to ozone is also exposed to the radiation, thus further contributing to the sterilization.

Abstract: An object of the present invention is to efficiently sterilize microorganisms present in or on a surface of a liquid. Plasma is generated in a vicinity of or in a manner to make contact with a liquid whose pH value is adjusted to become 4.8 or lower, more preferably 4.5 or lower. The plasma is generated in an atmospheric gas containing nitrogen, e.g., in the air. Superoxide anion radicals (O2?.) that are generated by the plasma react with protons (H+) in the liquid to form hydroperoxy radicals (HOO.). Further, nitrogen and oxygen included in the air are combined together by the action of plasma to form nitrogen oxide such as nitric oxide (NO.). The nitric oxide (NO.) combines with the hydroperoxy radicals (HOO.) to become peroxynitrite (ONOOH(ONOO?)) having a high microbiocidal activity.

Abstract: A process is described for the production of a catalyst preparation, in which the catalyst containing at least one inorganic compound which is solid under standard conditions is comminuted by means of a dispersion unit into particles having a maximum average particle size d50.3 of 2 ?m, preferably a maximum of 1 ?m, implemented in accordance with DIN 66141 and DIN 66144, and is distributed at a concentration of from 1 to 50 wt. % (relative to the finished catalyst preparation) in a liquid.

Abstract: Provided are a plasma sterilizing device and a method for generating a plasma in an elongated thin tube constituting a sterilizing object, and performing the sterilizing treatment of the interior of the elongated thin tube. The plasma sterilizing device and a method can sterilize even an elongated thin tube of an internal diameter of 5 mm or less efficiently, can prevent the inner wall of the elongated thin tube from being damaged, can suppress the danger of a secondary infection, and can suppress the contamination of the elongated thin tube by the sputtering of an electrode. The plasma sterilizing device comprises a container (2) capable of housing an elongated thin tube (1) or a sterilizing object and adjusting the internal pressure, and an electrode (5) arranged in at least one end portion of the elongated thin tube.

Abstract: The present disclosure relates to the decontamination of articles contaminated (or thought to be contaminated) with bioweapons, such as methods and apparatus for decontaminating articles contaminated with sporualated bioweapons. In some embodiments, the methods are methods of decontaminating an environment, for example a room or building contaminated with a bioweapon.