Abstract: An apparatus for the irradiation of a radiation sensitive material. The apparatus includes at least one thermally conductive tank for containing a heat transfer medium therein, said at least one thermally conductive tank having a first wall and a second wall in a parallel spaced relationship, said second wall having an outer surface for placing a radiation sensitive material thereon. Also disclosed is a system and method of irradiating a radiation sensitive material.

Abstract: An antimicrobial accessory may include a pressure sensitive adhesive and an antimicrobial mixed in the pressure sensitive adhesive. In some examples, an antimicrobial accessory may include at least one first domain comprising a pressure sensitive adhesive and a first antimicrobial and at least one second domain including a second polymer and a second antimicrobial. The antimicrobial accessory may be configured to be attached to a housing of an implantable medical device (IMD).

Abstract: It is aimed to prevent electrical charging inside a resin material as well as a surface of a resin vessel at a time of sterilizing the resin vessel by being irradiated with electron beam. A bottle support unit is mounted to a lower end portion of a cylindrical rotating shaft rotatably supported by a rotating wheel. The bottle support unit includes a pair of griper members by which a mouth portion of a bottle is gripped. The bottle rotated and conveyed in a state supported by the bottle support unit is irradiated with the electron beam from an electron beam irradiator to thereby sterilize the bottle. A ground electrode is disposed to be capable of being inserted into the interior of the resin vessel through a mouth portion thereof, and the interior of the resin vessel is irradiated with the electron beam in a state of the ground electrode being inserted into the resin vessel.

Abstract: This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.

Abstract: [PROBLEMS] To provide an efficient sterilization method for inexpensively sterilizing a medical article having a complex shape such as a body fluid treatment device of a generally-called dry or semi-dry type by so applying an electron beam that the overall absorbed dose distribution is small and to provide its application package form. [MEANS FOR SOLVING PROBLEMS] A method for sterilizing tubular body fluid treatment devices of a dry or semi-dry type contained in an electron beam-transmitting case with an electron beam. The method is characterized in that a stack structure which includes a gap layer having an average density of 0.010 to 0.180 g/cm3 and two body fluid treatment device layers having an average density of 0.050 to 0.200 g/cm3 and sandwiching the gap layer is contained in the electron beam-transmitting case, and the case is irradiated with the electron beam.

Abstract: The invention provides an article of manufacture comprising a substantially non-immunogenic xenograft for implantation into humans. The invention also provides methods for preparing a xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; treating the xenograft with crosslinking agents, and digesting the xenograft with a proteoglycan-depleting factor and/or glycosidase. The invention further provides a method for sterilizing xenograft material, having the steps of obtaining substantially non-immunogenic xenograft material; treating the xenograft material with at least one crosslinking agent; and subjecting the crosslinked xenograft material to radiation treatment.

Abstract: This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.

Abstract: The present invention is related to pre-connected disposable sets including a pre-connected bag containing a photosensitizer for use in a blood separation and pathogen inactivation procedure.

Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.

Abstract: The present invention relates to a method of packaging and a packaging system for treated stents which minimise the level of exposure of the stents to oxygen, moisture and light. The package comprises two compartments, the compartments being in communication with each other via a breathable membrane.

Abstract: Sterilization methods for implantable prostheses are described where a polymeric stent may be sterilized, e.g., via ETO sterilization, at a temperature below a glass transition temperature of the stent. A separate delivery catheter may be sterilized separately and the stent and delivery catheter may then be combined in an aseptic or semi-aseptic environment and sterilized as an assembled system such that the requirements for sterilizing the system are relatively lower. Additionally and/or alternatively, valve and filter assemblies may be used with an optional mandrel assembly for maintaining sterility of the internal components of a catheter system.

Abstract: The present invention provides a method sterilizing butyl rubber/styrene butadiene rubber (SBR) articles used in syringes or medical containers, comprising irradiating the butyl rubber/SBR elastomeric copolymer rubber article with gamma irradiation, wherein the SBR elastomeric copolymer comprises about 5% to about 50% of the rubber composition on a basis of total weight of the composition; and then exposing the irradiated rubber composition to a sterilizing gas for a time period sufficient to sterilize the rubber composition. The irradiated, sterilized rubber composition of the present invention is capable of maintaining superior performance standards with respect to sealability, recoverability from stress and elasticity.

Abstract: The invention concerns a method of sterilization and/or inactivation of at least one surface of at least one contaminated object. The method being characterized in that one subjects the surface to the discharge plasma generated from an applicator of electromagnetic field of linear type, the plasma having a temperature and an absorbed power per unit of volume predetermined by the operating conditions, so as to sterilize the surface without significantly degrading it. The invention also concerns a device enabling the sterilization and/or inactivation of at least one surface of at least one contaminated object by means of a plasma. This method and this device can be used to sterilize or inactivate several types of objects, such as packages, films, metal plates, dielectric plates, prosthesis used in the medical field, etc.

Abstract: A filter assembly for use with compressor assemblies such as oxygen concentrators, ventilators and other breathing apparatus including a compartmented housing member having at least one inlet opening, an outlet opening, a filter member, and an adjustment member associated with the at least one outlet opening for varying the size of the at least one outlet opening for adjusting the amount of ambient air entering the filter assembly.

Abstract: A method of forming plastic containers is disclosed.

Abstract: A method provides for sterilizing with radiation objects which have a low bioburden and which are sensitive to radiation. A dosage of radiation sufficient to ensure sterilization without damaging the object is determined by determining the bioburden upon one or more samples of the objects, determining an estimate of the dose that results in a preselected probability (e.g., 0.1, 0.01, 0.001, 0.0003162 . . . etc. (i.e., SAL=10?1, 10?2, 10?3, 10?3.5 . . . etc.

Abstract: Opposite sides of an article are irradiated to sterilize the article. The cumulative irradiation should be above a first value, and below a second value greater than the first value, at all of the positions in the article to provide the article with desired radiation benefits. Any amount of cumulative radiation between the first and second values is considered as optimal values. For a first range of article thicknesses, the cumulative radiation in the article is at the optimal values. For article thicknesses in a second range greater than in the first range, the cumulative radiation at positions in the article is greater than the optimal values. For article thicknesses in a third range greater than the second range, the cumulative radiation at the different positions in the article is at the optimal values. For the thicknesses in the second range, a member disposed in the radiation path weakens the radiation passing to the article, thereby reducing the cumulative radiation to an optimal value.

Abstract: A system and method including a wand-type ultraviolet (UV) light assembly positioned above a keyboard and other computer peripheral device(s) to be sanitized. The UV light assembly is preferably moved across the peripheral device surface to eliminate nearly all germs, bacteria, viruses, pathogens and other microorganisms that have accumulated on the surfaces of the keyboard and other peripherals. Desirably, the system operation is managed by a controller device which is in communication with a host computer. In addition, the system allows for the collection and analysis of system performance data. The invention provides an extremely effective, compact, virtually cost-free and environmentally-friendly solution to disinfecting surfaces of keyboards and other peripheral devices.

Abstract: The invention relates to a plasma source (1) comprising: a conduit (3, 4) carrying a gas flow and an ionization chamber (10) in which a plasma is generated, wherein the ionization chamber (10) is connected to the conduit (3, 4), so that the gas flow in the conduit (3, 4) carries away gas particles out of the ionization chamber (10) thereby reducing the pressure in the ionization chamber (10).

Abstract: The present invention provides a method and a container for sterilizing a soft contact lens and for providing a sterilized storage package of the soft contact lens maintained in a packaging solution. By using the method and container of the invention, deformations of soft contact lenses during autoclave can be substantially reduced.

Abstract: A system and method are provided for the thermal and non-thermal (oxidation) plasma treatment of medical waste using an electrode-less induction (thermal) and capacitive (non-thermal) plasma torches. The medical waste is pre-treated by liquid nitrogen, crushed and pulverized by LN2 crusher/pulverizer, and conveyed to the nitrogen/water thermal plasma reactor, which converts the powdered medical waste into carbon black and generated gas (resulting from the thermal step) is directed to the Oxygen non-thermal plasma reactor for post-treatment. The system is equipped with an emission control unit, dual frequency pulse RF power supply, and Liquid Nitrogen Generator. The off gas from LN2 crusher (nitrogen) is used for the induction plasma torch and off gas from LN2 generator (oxygen) is used as a plasma gas for the Non-thermal plasma torch.

Abstract: A device for treating liquid medium has an ultrasound emitter located relative to a compartment of a container holding a liquid medium and a microbubble emitter located relative to the compartment. The ultrasound emitter emits high-frequency ultrasound between about 200 KHz and 10 MHz. The microbubble emitter emits bubbles with an average diameter of less than 1 mm.

Abstract: An apparatus and method for generating a desired smell by processing smell information through a combination of a computer system and a perfume generating means. In order to generate a desired smell under control of a computer, preset perfume information concerning a smell classification table, kinds of preset perfume corresponding to the items of smell in the smell classification table, the amount of smell to be generated and the variation with time of the amount is registered, the item of a specific smell is selected from the smell classification table, and relevant pieces of the preset perfume information corresponding to the item of the specific smell is extracted. A deodorant may be combined or various smells may be combined with an image.

Abstract: A device for locally producing microwave plasma. The device comprises at least one microwave feed that is surrounded by at least one dielectric tube. At least one of the dielectric tubes, such as an outer dielectric tube, is partially surrounded by a metal jacket. A locally delimited plasma is produced by the device by shielding microwaves.

Abstract: Aspects of the invention relate to a device and method for non-contact inactivation of undesirable and/or harmful microorganisms in products using high-voltage nanosecond pulsed electrical field. In certain embodiments, a product may be packaged into a container which is made from a dielectric material and placed between electrodes to be processed by a pulsed electrical field. In certain embodiments, the electrodes, together with the container, may be placed into a treatment assembly filled with a high dielectric permeability media that allows the formation of a quasi-uniform electrical field inside the product and prevents the electrical breakdown of the dielectric material of the container. The electrodes may be connected to a high voltage generator, which forms nanosecond pulses that allow an electrical field of high intensity to penetrate the dielectric material of container walls and gaps between the electrodes and the container's walls to the product without significant energy losses.

Abstract: Absorbable radiation or radiochemically sterilized medical devices, including sutures, whose breaking strength and absorption profile can be modulated by controlling the total dose received during sterilization are disclosed.

Abstract: The present invention relates to a process for the sterilization and/or germ reduction of impression material by means of radiation.

Abstract: The present invention relates an apparatus that reduces and/or eliminates germs and/or bacteria from the soles of a person's footwear, and an associated method of use. According to an exemplary embodiment of the present invention, a person can step onto and stand on the exemplary apparatus to have germs and/or bacteria reduced and/or eliminated from the soles of his or her footwear through the use of anti-germicidal and/or antimicrobial radiation and/or light. An exemplary apparatus according to an exemplary embodiment of the present invention can be configured so that when a person stands on a top portion, the person's footwear sinks to a bottom portion that is substantially transparent, displacing substantially opaque gel so that at least one of the soles of the person's footwear is exposed to the anti-germicidal and/or antimicrobial radiation and/or light source.

Abstract: A method provides for sterilizing with radiation objects which have a low bioburden and which are sensitive to radiation. A dosage of radiation sufficient to ensure sterilization without damaging the object is determined by determining the bioburden upon one or more samples of the objects, determining an estimate of the dose that results in a probability of 0.01 of a surviving microorganism by testing a quantity of samples of the objects at varying dosage levels of radiation, confirming the estimate by testing a quantity of samples of the objects at the dose that was estimated; and calculating a dosage for the sterility assurance level of 10-6 by adding a factor to the dose that was confirmed to result in a probability of 0.01 of a surviving microorganism and wherein the factor is proportional to the dose that yields a probability of 0.01 of a surviving microorganism and inversely proportional to a log of the bioburden.

Abstract: A pharmaceutical composition comprising 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine that is stable to sterilization and suitable for topical application directly to tissue sites where the dermis has been breached, and has been sterilized, packaged compositions that have been sterilized, and methods of sterilizing these compositions are disclosed.

Abstract: Package components for the radiochemical sterilization of medical devices contain paraformaldehyde as the precursor of the radiolytically generated, sterilizing dose of formaldehyde, premixed with a particulate solid dispersant of, preferably, polyethylene or silica gel, which facilitates the free passage of the formaldehyde to the package gaseous environment or additionally, absorbs trace amounts of moisture in the package, thus, facilitating the device manufacturing process and increasing shelf-stability.

Abstract: This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.

Abstract: The present invention relates to a process for sterilizing a contaminated object. The process comprises the insertion of the object in a sterilization chamber having at least one discharge tube in communication therewith. Then, the tube is fed with a liquid or gas stream, and the stream is subjected to an electric field so as to generate a plasma, thereby exposing the contaminated object to the action of sterilizing species that are present in a post-discharge zone or in a zone of excitation of the plasma. A device for carrying such a process is also provided.

Abstract: A sterilization process that preserves the mechanical properties of dilatation balloons and balloon catheters manufactured from polymers susceptible to the degradation reactions induced by ionizing radiation. The advantages of the sterilization process contemplated by this invention results from a reduced oxygen environment during sterilization, thereby preventing the degeneration process initiated in polymers during irradiation. Additionally, a balloon or balloon dilatation catheter sterilized by the process of the invention is provided.

Abstract: There is provided a process for at least partially deactivating microorganisms in a solid material. The process comprising submitting the solid material to an electric current having a voltage gradient of at least 3 volts per centimeter of solid material to be treated, and a current density of at least 2 mA per cm2 with respect to the surface of electrodes used for generating the current.

Abstract: In a reaction chamber, which constitutes a component of a process installation for obtaining foodstuffs or foodstuff components, biological products in harvested form that are whole or in pieces are subjected to pulsed electric fields as they pass through said reaction chamber, said electric fields forming pores in the cell walls so as to irreversibly open the latter, thus making the content of the cells more easily accessible. This is achieved by electrode groups, which can be energized to a high voltage and are located in the wall of a longitudinal passage of the reactor through which the process material is moved past grounded electrodes located in an opposing longitudinal wall area. Each electrode group is connected to an electric energy accumulator such as for example, a Marx generator, by means of a switch, in order to rapidly establish electric fields of multiple directions between the charged and the grounded electrodes.

Abstract: A system for sanitizing an enclosed structure comprises a first sensor, a second sensor, a third sensor, a germicidal ultraviolet light source, a motor, and a controller. The first sensor detects the presence of humans or animals within the enclosed structure. The second sensor detects the position of at least one door of the enclosed structure. The third sensor detects tampering with the system. The ultraviolet light source provides electromagnetic radiation in the ultraviolet range. The motor moves the ultraviolet light source from an inactive position to an active position and from the active position to the inactive position. The controller receives inputs from the first sensor, the second sensor, and the third sensor, and transmits outputs to the ultraviolet light source and the motor.

Abstract: Glycolic disinfectant compositions and related methods and apparatus for electrostatic dispensation.

Abstract: Method for sterilising containers (10), wherein a treatment head (5) is guided into the interior of a container (10) to be sterilised and the treatment head (5) emits radiation in the interior of the container (10) at least intermittently over a predefined time period (dT), wherein the container (5) is moved relative to the treatment head (5) in a longitudinal direction (L) of the container (10) at least intermittently at a relative movement speed (v) over the predefined time period (dT). According to the invention, this relative movement speed (v) of the treatment head (5) located in the interior of the container (10) varies over the predefined time period and is controlled as a function of an internal profile (10a) of the container (10).

Abstract: The novel sterilization process disclosed herein still relies on the sterilization action resulting from exposure of the liquids and inner surfaces of the medical article to appropriate temperatures for well-determined times, but the sterilization temperature shall be attained through generation of heat in the article itself and not through heat transfer from outside to inside. This shall be obtained through the generation of a medium to high frequency electromagnetic field, whose characteristics are precisely determined to reach the desired temperature in as little time as possible and to maintain it for the time required for safe sterilization of the article.

Abstract: The invention relates to a sterilization method and to an installation (10) for producing sterile bottles (14) by blow molding sterilized preforms (12) according to the method, characterized in that, at the spraying station (28), the flow (F) of sterilizing product is atomized onto each preform (12) whose temperature (T1) is less than the condensing temperature (Tc) of the sterilizing product so that a film of mist of the sterilizing product deposits by condensation at least onto the inner wall to be sterilized, and is characterized in that, at the activation station (50) of the sterilizing product of the sterilizing unit (26), each preform (12) treated in the aforementioned manner is heated by radiation to a temperature (T2) greater than or equal to the activation temperature (Ta) in order to sterilize at least the inner wall of the preform (12).

Abstract: A method for manufacturing of ultrahigh molecular weight polyethylene (UHMWPE) for implants, where the implants have been machined out of UHMWPE blocks or extruded rods, has anthocyanin dispersely imbedded in the polyethylene. The implant is then exposed to ? ray or electron beam irradiation in an amount of at least 2.5 Mrad followed by a heat treatment to prevent the implant from becoming brittle in the long term as well as to improve strength and wear. The method includes mixing a powder or granulate resin of UHMWPE with an aqueous liquid that contains anthocyanin in a predetermined amount. The water is then evaporated in order to deposit the anthocyanin in a predetermined concentration on the polyethylene particles. The doped UHMWPE particles are compressed into blocks at temperatures in a range of approximately 135° C.-250° C. and pressures in a range of approximately 2-70 MPa. Medical implants are made from the blocks.

Abstract: A method and system to measure misalignment error between two overlying or interlaced periodic structures are proposed. The overlying or interlaced periodic structures are illuminated by incident radiation, and the diffracted radiation of the incident radiation by the overlying or interlaced periodic structures are detected to provide an output signal. The misalignment between the overlying or interlaced periodic structures may then be determined from the output signal.

Abstract: A system and method for implementing embedded electronics in environments where radiation or extreme temperatures are used is disclosed. Embedded electronics are affixed to various components of a pharmaceutical system, thereby enabling the customer to download pertinent information about the component, such as lot number, date of manufacturer, test parameters, etc. Additionally, these electronics allow an array of functions and features to be implemented, such as integrity tests and diagnostics. The electronics in the pharmaceutical components utilize a technology that is not as susceptible to radiation and extreme temperatures as traditional electronics.

Abstract: A device for analyzing body fluids comprising a lancing element that can puncture a body part along a lancing axis. The lancing element has a collection volume for collecting body fluid obtained by a puncture and a receiving element that can be loaded with body fluid from the collection volume and that can detect a component of the body fluid. The lancing element and the receiving element are arranged in the lancing axis so that they can be moved relative to one another such that the receiving element dips into the collection volume in the lancing direction during a transfer phase following the puncture.

Abstract: An apparatus, system and method for verifying the achievement of a desired sterility assurance level (SAL) for components manipulated within a low-energy electron beam sterilization chamber. The components are preferably pre-sterilized and connected together in an assembly fashion which creates and maintains the sterility of the connection by subjecting the components to low-energy (less than 300 KeV) electron beam radiation. The verification is completed by measuring the sterilization dose delivered to a sensor, also known as a dosimeter, positioned within the sterilization process to simulate the components.

Abstract: A sanitizing apparatus for writing utensils comprising a housing assembly and an ultraviolet and ozone generating assembly housed therein. The housing assembly comprises a top wall, a base and four walls. The first and second walls are perpendicularly disposed with respect to the third and fourth walls. The third and fourth walls are lateral walls. The housing assembly also comprises an angled wall that protrudes outwardly beyond the top wall and beyond the first wall defining a tray that terminates with a lip for preventing the writing utensil from falling off. A battery compartment is also housed within the housing assembly. The ultraviolet and ozone generating assembly radiates the writing utensil within the housing assembly with rays and ozone, to effectively sterilize bacteria and biological germs existing on the writing utensil. A visual indicator notifies a user when the ultraviolet and ozone generating assembly is operating.

Abstract: A system for disinfecting a fluid containing microorganisms or chemical contaminants includes a plurality of photocatalyst surfaces secured to a solid surface upon which a fluid to be disinfected contacts. A structure for removing a portion of the photogenerated electrons is in electrical contact with the photocatalyst layer, wherein an electron-hole recombination rate involving the photogenerated electrons and holes is reduced, thus increasing the removal rate of microorganisms or chemical contaminants from the fluid. The system can include a source of photons having a wavelength corresponding to a band gap energy of the photocatalyst to illuminate the photocatalyst layer. The invention can be used in air supply registers of a heating, ventilating and air conditioning system, or in air ducts, or used to disinfect wall coverings, floor coverings, envelopes, packages, and clothing articles.

Abstract: Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.

Abstract: Devices and methods for treating, preventing from growth, and neutralizing hyperproliferative, undifferentiated, or virally infected cells in a liquid medium using high-frequency, low-energy ultrasound.