In Atmosphere Other Than Air Patents (Class 422/23)
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Publication number: 20090232700Abstract: The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and separately sterilizing this partial assemblage and the binding reagent. The sterilized binding reagent and the sterilized partial assemblage are then aseptically assembled to produce the sterilized biosensor. Other embodiments of the methods described herein comprise assembling substantially all of the components of the biosensor, including the binding reagent, and sterilizing the assembled biosensor to produce a sterilized biosensor.Type: ApplicationFiled: May 12, 2009Publication date: September 17, 2009Inventors: Javier Alarcon, Kristin Weidemaier, David M. Kurisko, Srinivasan Sridharan
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Publication number: 20090175757Abstract: The present invention provides titanium dioxide/single-walled carbon nanotube composites (TiO2/SWCNTs), articles of manufacture, and methods of making and using such composites. In certain embodiments, the present invention provides membrane filters and ceramic articles that are coated with TiO2/SWCNT composite material. In other embodiments, the present invention provides methods of using TiO2/SWCNT composite material to purify a sample, such as a water or air sample.Type: ApplicationFiled: May 14, 2008Publication date: July 9, 2009Applicant: Northwestern UniversityInventors: Yuan Yao, Gonghu Li, Kimberly Gray, Richard M. Lueptow
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Publication number: 20090074610Abstract: It has been determined that gamma sterilization of biodegradable polymer stents does not cause significant polymer cross-linking and collapse. Using sufficient spacing can lead to stents that display little if any detrimental effects from the procedure. In certain embodiments, using structures in the general region of about 100 micron spacing between the struts leads to highly functional stents that do not fuse. Further, the resulting stent has radially homogenous mechanical properties. Therefore, the stent has a uniform expansion within the lumen.Type: ApplicationFiled: March 13, 2007Publication date: March 19, 2009Inventor: Patrick Sabaria
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Patent number: 7504066Abstract: A method for sterilizing at least one item in a chamber, comprising the steps of: disposing the at least one item in the chamber; pumping the atmosphere from the chamber until the atmosphere of the chamber has a pressure of less than ten torr; adding water vapor and ozone to the chamber; and generating electrical discharge in the chamber, such that the electrical discharge produces OH radicals from the water vapor and the ozone so as to contribute to sterilization of at least part of the at least one item.Type: GrantFiled: September 11, 2003Date of Patent: March 17, 2009Assignee: Tuttnauer Israel Ltd.Inventors: Gena Perlov, Boris Malkin, Shmuel Yannai
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Publication number: 20090053101Abstract: An object to be sterilized is disposed inside a vacuum chamber, and the inside of the vacuum chamber is evacuated. When the pressure inside the vacuum chamber reaches 3 Pa, a cutoff valve disposed between the vacuum chamber and the vacuum pump is closed. High-frequency power is supplied to an electrode. Oxygen gas is introduced into the vacuum chamber for 0.1 sec. Thereafter, the pressure is held constant for 3 sec. Until the pressure inside the vacuum chamber reaches 10 kPa, introduction of oxygen gas into the vacuum chamber is repeated. When the pressure reaches 10 kPa, the cutoff valve is opened to evacuate the inside of the vacuum chamber and the supply of the high-frequency power is stopped. Introducing the oxygen gas and determining pressure inside the vacuum chamber is repeated, and after 90 min, the pressure inside the vacuum chamber is returned to atmospheric pressure.Type: ApplicationFiled: January 11, 2007Publication date: February 26, 2009Applicants: ELK CORPORATION, SAGA UNIVERSITYInventors: Yasushi Hanada, Nobuya Hayashi
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Patent number: 7485258Abstract: A method and device for sterilizing containers in which a plasma treatment is executed through excitation of an electromagnetic oscillation so that the plasma is excited in a vacuum in the vicinity of the container regions to be sterilized. Between arrival and discharge, the container regions to be sterilized are moved closer to the oscillation-generating device in the chamber, with continuous movement of the container and/or of the oscillation-generating device for one or more predetermined time intervals in such a way that a plasma is excited in these regions inside and/or outside the container. The chamber is provided with a transport apparatus inside it, which produces an essentially rotating motion of the container during the transport from the arrival to the discharge in the chamber.Type: GrantFiled: July 9, 2002Date of Patent: February 3, 2009Assignee: Robert Bosch GmbHInventors: Kurt Burger, Guenter Schneider, Thomas Beck, Wolfgang Szczerba, Bernd Wilke, Johannes Rauschnabel, Sascha Henke, Bernd Goetzelmann, Heinrich Van De Loecht, Wolfgang Schmitt
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Publication number: 20080267811Abstract: An object of the present invention is to provide a material for more easily and accurately detecting treatment status using gas exposure. The present invention relates to an ink composition for detecting an oxidizing gas, or the like, comprising at least one type of azo dye, methine dye, triarylmethane dye and thiazine dye.Type: ApplicationFiled: March 30, 2005Publication date: October 30, 2008Applicant: SAKURA COLOR PRODUCTS CORPORATIONInventors: Norihiro Yamaguchi, Kyoko Sano, Hiroshi Inoue
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Patent number: 7428807Abstract: A vacuum packaging system for transporting a plurality of medical containers including a tray that supports the medical containers and an air impervious flexible film defining an internal cavity. The air impervious flexible film completely surrounds the tray and the medical containers. The internal cavity is evacuated to a predetermined vacuum level below atmospheric pressure. A method for packaging the plurality of medical containers for transportation in the tray includes inserting the medical containers into the tray, inserting the tray filled with medical containers into the internal cavity, evacuating the internal cavity to a predetermined vacuum pressure and sealing the flexible film such that the predetermined vacuum pressure is generally maintained in the internal cavity.Type: GrantFiled: March 1, 2007Date of Patent: September 30, 2008Assignees: West Pharmaceutical Services, Inc., Daikyo Seiko Ltd.Inventors: Edward Vander Bush, Robert Nase, Hiroshi Togashi, Hubert Jansen, John Paproski
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Publication number: 20080193330Abstract: A surface treatment apparatus encompasses a gas introducing system configured to introduce a process gas from one end of a tubular treatment object; a vacuum evacuating system configured to evacuate the process gas from other end of the treatment object; an excited particle supplying system disposed at the gas supply upstream side to the treatment object, configured to supply excited particles for inducing initial discharge in a main body of the treatment object; and a first main electrode and a second main electrode disposed oppositely to each other, defining a treating region of the treatment object as a main plasma generating region disposed therebetween, wherein the excited particle supplying system is driven at least until generation of main plasma, and main pulse of duty ratio of 10?7 to 10?1 is applied between the first main electrode and second main electrode, to generate a non-thermal equilibrium plasma flow inside the treatment object, and thereby an inner surface of the treatment object is treated.Type: ApplicationFiled: July 19, 2007Publication date: August 14, 2008Applicants: TOKYO INSTITUTE OF TECHNOLOGY, NGK INSULATORS, LTD.Inventors: Eiki Hotta, Naohiro Shimizu, Yuichiro Imanishi
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Publication number: 20080138243Abstract: The invention relates to a method for irradiating partly formed packages (10) with electron beam irradiation from at least one electron beam sterilizing device (18), characterized in that it comprises: providing at least one partly formed package (10) to be irradiated in a gaseous environment, and exposing the gaseous environment to a pre-determined pressure regulation cycle and exposing the partly formed package (10) to irradiation at least during a portion of said pressure regulation cycle. The invention also relates to a device for realizing said method. The invention further relates irradiation of a packaging material web.Type: ApplicationFiled: December 11, 2007Publication date: June 12, 2008Applicant: Tetra Laval Holdings & Finance S.A.Inventors: Anders Kristiansson, Lars Ake Naslund
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Patent number: 7364694Abstract: A prosthetic implant made of polyethylene is packaged in a sterile manner by being placed in a flexible, gas-impermeable sachet after which a vacuum is created in the sachet and it is hermetically closed. The sachet is subsequently placed in a gas-impermeable envelope and an inert gaseous atmosphere is established in the envelope and the envelope is closed hermetically. The assembly formed by the implant, the sachet and the envelope is then exposed to radiation.Type: GrantFiled: December 9, 2003Date of Patent: April 29, 2008Assignee: TornierInventor: Alain Tornier
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Publication number: 20070286766Abstract: Disclosed is an apparatus for cleaning an exhaust line of reaction chambers. The apparatus comprises plasma chambers into which a fluorine or chlorine gas is induced from a gas supply unit as a source of fluorine or chlorine radicals for removing solid deposits in the exhaust line, and a plasma source supply mechanism to convert the fluorine or chlorine gas into the fluorine or chlorine radicals through application of power to the fluorine or chlorine gas. The plasma source supply mechanism comprises an RF generator, antennas surrounding the plasma chamber to convert the fluorine or chlorine gas into the fluorine or chlorine radicals after receiving RF power, a relay switch for selection of RF supply to connect the RF generator with the plasma chambers, and a controller to control the RF power. The radicals are supplied to the exhaust line, and serve to remove the solid deposits.Type: ApplicationFiled: November 8, 2006Publication date: December 13, 2007Applicant: TERATECH CO., LTD.Inventor: Byoung-Chun Choi
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Patent number: 7291314Abstract: An apparatus subjects water to waves from an RF plasma. This allows continuous production of “activated water” characterized by cluster sizes below about 4 molecules per cluster, water having pH below 4 or above 10, or water having ORP of less than ?350 mV or more than +800 mV. The basic frequency of the plasma is preferably between 0.44 MHz and 40.68 MHz, and the plasma is preferably modulated at a frequency between 10 kHz and 34 kHz. Flow rates typically range from 20 l/hr to about 2000 l/hr. Activated water can be used for many purposes, including antimicrobial cleaning of worktable, floor, wall, knife, transport and other surfaces, for example, in meat processing facilities and hospitals.Type: GrantFiled: December 20, 2001Date of Patent: November 6, 2007Assignee: Hydro Enterprises, Inc.Inventors: George Paskalov, Mark Gorodkin, Viktor Sokolov
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Publication number: 20070231201Abstract: A method is provided for inactivating prions and is particularly effective in inactivating prions on medical devices. An article having a quantity of prions thereon is placed into a sterilization chamber. Pressure in the sterilization chamber is lowered to a pressure below the vapor pressure of hydrogen peroxide and a solution of hydrogen peroxide is admitted into the sterilization chamber and placed into contact with the article to inactivate prions on the article.Type: ApplicationFiled: March 31, 2006Publication date: October 4, 2007Inventors: Charles G. Roberts, Martin Favero
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Patent number: 7252799Abstract: Methods are disclosed for sterilizing preparations containing albumin to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations containing albumin, such as plasma protein fractions, with irradiation.Type: GrantFiled: August 31, 2001Date of Patent: August 7, 2007Assignee: Clearant, Inc.Inventors: Shirley I. Miekka, Wilson Burgess, William N. Drohan, Martin J. Macphee, Randall S. Kent, David M. Mann, Yuri Griko
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Patent number: 7229589Abstract: A method for decontamination of a contaminated region containing biological species to be destroyed, includes a decontamination step during which a decontamination gas containing atomic nitrogen is propagated in the contaminated region, and atomic nitrogen contributes to the destruction of biological species in the contaminated region.Type: GrantFiled: June 30, 2003Date of Patent: June 12, 2007Assignees: Centre National de la Recherche Scientifique--CNRS, Universite Paris Sud(Paris 11)Inventors: Mihaï Ganciu Petcu, Anne-Marie Pointu, Bernard Legendre, Johannes Orphal, Michel Vervloet, Michel Touzeau, Najet Yagoubi
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Patent number: 7192553Abstract: A sterilization and decontamination system in which a non-thermal plasma discharge device is disposed upstream of a suspension media (e.g., a filter, electrostatic precipitator, carbon bed). The plasma discharge device generates a plasma that is emitted through apertures (e.g., capillaries or slits) in the primary dielectric. Plasma generated active sterilizing species when exposed to contaminants or undesirable particulate matter is able to deactivate or reduce such matter in contaminated fluid stream and/or on objects. Thus, the undesirable contaminants in the fluid to be treated are first reduced during their exposure to the plasma generated active sterilizing species in the plasma region of the discharge device. Furthermore, the plasma generated active sterilizing species are carried downstream to suspension media and upon contact therewith deactivate the contaminants collected on the suspension media itself. Advantageously, the suspension media may be cleansed in situ.Type: GrantFiled: November 4, 2002Date of Patent: March 20, 2007Assignees: Plasmasol Corporation, Stevens Institute of TechnologyInventors: Richard Crowe, George Korfiatis, Sergei Babko-Malyi
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Patent number: 7156957Abstract: Nitric oxide in a gaseous stream is converted to nitrogen dioxide using oxidizing species generated at least in part using in situ UV radiation sources. The sources of the oxidizing species include oxygen and/or hydrogen peroxide. The oxygen may be a component of the gaseous stream or added to the gaseous stream, preferably near a UV radiation source, and is converted to ozone by the UV irradiation. The hydrogen peroxide is decomposed through a combination of vaporization and UV irradiation. The hydrogen peroxide is preferably stored at stable concentration levels, i.e., approximately 50% by volume, and increased in concentration in a continuous process preceding vaporization within the flow channel of the gaseous stream and in the presence of the UV radiation sources.Type: GrantFiled: May 15, 2003Date of Patent: January 2, 2007Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Clyde F. Parrish, Dale E. Lueck
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Patent number: 7150853Abstract: A method of sterilizing a medical device component, such as a catheter balloon, in which an electron beam (i.e., e-beam) is applied to the component in an evacuated or inert gas-filled container. The method of the invention allows for electron beam sterilization without significant degradation of the component polymeric material. In one embodiment, the device component is configured to be pressurized or expanded during use. The method of the invention provides a component with a rupture pressure that is not significantly decreased due to electron beam sterilization. Another aspect of the invention is a medical device component, e-beam sterilized according to a method of the invention. A variety of medical device components can be sterilized by the method of the invention, and particularly intracorporeal devices for therapeutic or diagnostic purposes, such as balloon catheters, catheter shafts and balloons, stent covers, and vascular grafts.Type: GrantFiled: November 1, 2001Date of Patent: December 19, 2006Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Jeong S. Lee, Kenneth L. Wantink
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Patent number: 6986868Abstract: A method for sterilizing a medical device having a hydrophilic coating using radiation, said method including the steps of bringing the medical device having such coating in contact with an aqueous liquid for wetting the hydrophilic coating, said liquid including a solution of a hydrophilic polymer, and sterilizing the device by applying a sufficient amount of radiation to provide a coated device showing a significantly increased and prolonged water retention and lower friction coefficient when wet.Type: GrantFiled: May 18, 2001Date of Patent: January 17, 2006Assignee: Coloplast A/SInventor: Niels Jørgen Madsen
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Patent number: 6984361Abstract: A gaseous blend of Ox and a method for significantly reducing the biological load, including anthrax, on mail and shipping parcels is disclosed. The gaseous blend of Ox consists at least in part of O3. The method involves applying a continuous stream of oxygen-containing, i.e., Ox, gas to the mail or shipping parcel at a predetermined temperature, pressure and relative humidity. The continuous stream of Ox gas is prepared in an Ox generation cell, which contains a means for generating the Ox gas at a pressure less than 20 lbs/in2 using, for example, one or more of the following: corona discharge, high frequency electrical discharge, ultraviolet light, x-ray, radioactive isotope and electric beam.Type: GrantFiled: January 10, 2002Date of Patent: January 10, 2006Assignee: Cosmed Group, Inc.Inventors: Gary B. Carman, Stephen K. Wirtz
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Patent number: 6969486Abstract: An apparatus for treating pollutants in a gas may include a source of hydrogen peroxide, and a treatment injector for creating and injecting dissociated hydrogen peroxide into the flow of gas. The treatment injector may further include an injector housing having an inlet, an outlet, and a hollow interior extending therebetween. The inlet may be connected in fluid communication with the source of hydrogen peroxide so that hydrogen peroxide flows through the hollow interior and toward the outlet. At least one ultraviolet (UV) lamp may be positioned within the hollow interior of the injector housing. The at least one UV lamp may dissociate the hydrogen peroxide flowing through the tube. The dissociated hydrogen peroxide may be injected into the flow of gas from the outlet for treating pollutants, such as nitrogen oxides.Type: GrantFiled: January 18, 2002Date of Patent: November 29, 2005Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Charles David Cooper, Christian Anthony Clausen
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Patent number: 6955786Abstract: A gaseous blend of CO2 and Ox and a method for applying a continuous stream of a gaseous blend of CO2 and Ox to a material are disclosed. The gaseous blend and the method significantly reduce the biological load on consumer products, such as food products, botanicals and cosmetic ingredients; in building structures; on transportation containers; and in soil.Type: GrantFiled: March 15, 2002Date of Patent: October 18, 2005Assignee: Cosmed Group, Inc.Inventors: Gary B. Carman, Steven K. Wirtz
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Patent number: 6916445Abstract: A system for irradiating mail, comprising a device for conveying mail along a predetermined path and a device for irradiating the mail moving along the path with a beam of electrons. An apparatus for chilling the mail is provided along the path. The apparatus exposes the mail to a low-temperature, gaseous fluid created using a cryogenic fluid.Type: GrantFiled: November 27, 2002Date of Patent: July 12, 2005Assignee: STERIS Inc.Inventors: Michael A. Centanni, Mark Kusner
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Patent number: 6908591Abstract: Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, spores, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.Type: GrantFiled: July 18, 2002Date of Patent: June 21, 2005Assignee: Clearant, Inc.Inventors: Martin MacPhee, Glenn Calvert, Tom Lynch, Randall S. Kent, David Mann, Wilson Burgess, Shirley Miekka, William N. Drohan
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Patent number: 6875400Abstract: A method includes providing an article including an oxygen scavenger; forming the article into a container; placing an oxygen sensitive product into the container; and exposing the container to actinic radiation at a dosage effective to sterilize the container, and trigger the oxygen scavenger in the article. Alternative methods are also disclosed. A package includes a container, the container including an activated oxygen scavenger; wherein the container is sterilized; and wherein an oxygen sensitive product is disposed in the container.Type: GrantFiled: May 18, 2001Date of Patent: April 5, 2005Assignee: Cryovac, Inc.Inventors: Drew V. Speer, Ronald L. Cotterman
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Publication number: 20040262146Abstract: A sterilization system applies power in the form of bipolar pulsed DC to a plasma during a gas/plasma sterilization procedure.Type: ApplicationFiled: June 30, 2004Publication date: December 30, 2004Inventors: Robert C. Platt, Anthony Lemus, Alfredo M. Choperena
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Publication number: 20040265166Abstract: A method for decontamination of a contaminated region containing biological species to be destroyed, comprising a decontamination step during which a decontamination gas containing atomic nitrogen is propagated in contaminated region, and atomic nitrogen contributes to the destruction of biological species in contaminated region.Type: ApplicationFiled: June 30, 2003Publication date: December 30, 2004Inventors: Mihai Ganciu Petcu, Anne-Marie Pointu, Bernard Legendre, Johannes Orphal, Michel Vervloet, Michel Touzeau, Najet Yagoubi
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Patent number: 6793884Abstract: A method and apparatus for significantly reducing the biological load on consumer products such as food products, botanicals, cosmetic ingredients and medical products is disclosed. The method involves applying a continuous stream of oxygen-containing, i.e., Ox, gas to a material in a sealed biological burden reduction chamber. The continuous stream of Ox gas is prepared in an Ox generation cell, which contains a means for generating the Ox gas at a pressure less than 20 lbs/in2 using, for example, one or more of the following: corona discharge, high frequency electrical discharge, ultraviolet light, x-ray, radioactive isotope and electric beam.Type: GrantFiled: July 13, 2001Date of Patent: September 21, 2004Assignee: Cosmed Group, Inc.Inventors: Gary B. Carman, Stephen K. Wirtz
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Patent number: 6790410Abstract: The invention relates to a method for hydrogen peroxide plasma sterilization, wherein the chamber temperature is set at less than 39° C. throughout, and containers with temperature-sensitive products can be efficiently sterilized without the temperature-sensitive products showing a significant loss of activity or degradation.Type: GrantFiled: January 23, 2002Date of Patent: September 14, 2004Assignee: Aventis Behring GmbHInventors: Hubert Metzner, Joerg Lemmer, Horst Naumann
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Patent number: 6790409Abstract: A method of disinfecting a contact lens is provided, including the steps of preparing a disinfecting liquid which contains water-dispersible fine particles of a titanium oxide dispersed in an aqueous medium, immersing the contact lens in the disinfecting liquid; and irradiating the disinfecting liquid in which the contact lens is immersed, with a light.Type: GrantFiled: October 27, 2000Date of Patent: September 14, 2004Assignee: Menicon Co., Ltd.Inventors: Chikako Nakamura, Kazuhiko Nakada, Tatsuya Hayashi, Kotaro Sakanishi
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Publication number: 20040170527Abstract: A method for sterilizing a device, includes the following steps: placing the article into a chamber containing an inner atmosphere; placing a solution comprising hydrogen peroxide and water into fluid communication with the chamber, the solution having a ratio of hydrogen peroxide to water; vaporizing the solution in the inner atmosphere to form water vapor and hydrogen peroxide vapor; selectively drawing water vapor from the chamber to increase a ratio of hydrogen peroxide to water in the chamber; and contacting the article with the hydrogen peroxide vapor.Type: ApplicationFiled: January 26, 2004Publication date: September 2, 2004Inventors: Paul T. Jacobs, Szu-Min Lin, Jenn-Hann Wang
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Publication number: 20040120850Abstract: A treatment system for treating objects (e.g., medical instruments) with ozone gas. The ozone treatment system includes a treatment tank wherein the objects are exposed to ozone. In a preferred embodiment, the ozone is generated within the treatment tank by exposing an oxygen-containing gas to ultraviolet radiation produced by a laser.Type: ApplicationFiled: December 20, 2002Publication date: June 24, 2004Applicant: STERIS Inc.Inventor: Herbert J. Kaiser
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Patent number: 6749806Abstract: The present invention relates to a method of sterilizing fungi and bacteria in a spore state for sterilizing fungi and bacteria in a spore state for sterilizing fungi and bacteria in a spore state and a sterilizer thereof. In particular, the invention is directed to a method of sterilizing sterilization targets adhering onto target-adhering things such as containers, packing materials, conveying tools, etc. or sterilization targets contained in target-containing things such as liquid, air, raw materials, etc. and also a sterilizing device thereof. Some of fungi and bacteria in a spore state are strong to ultraviolet rays, and some of them are strong to heat. So, both the fungi and so on which are strong to ultraviolet rays and those which are strong to heat can be effectively sterilized by performing successively the sterilization by UV radiation and heat.Type: GrantFiled: May 31, 2002Date of Patent: June 15, 2004Assignee: Hoshin Kagaku Sangyosho Co., Ltd.Inventors: Masashi Koji, Ken Shimizu
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Patent number: 6746647Abstract: A method is provided for rapidly determining whether a load of equipment to be sterilized in a sterilization chamber absorbs, adsorbs, condenses, or decomposes significant amounts of germicide vapor or gas, such as hydrogen peroxide. The initial slope of the curve of a plot of ln(c/c0) versus time is determined, where c is the concentration of hydrogen peroxide and c0 is the maximum concentration of hydrogen peroxide. The initial slope is determined in the first 100 seconds after the maximum in the concentration of hydrogen peroxide. If the initial slope is approximately 0.016 sec−1 or less, the load is acceptable. If the initial slope is significantly steeper than 0.016 sec−1, the load absorbs, adsorbs, condenses, or decomposes significant amounts of hydrogen peroxide. If the slope of the curve is steep, the system can abort the sterilization run before significant amounts of hydrogen peroxide have been absorbed, adsorbed, or condensed.Type: GrantFiled: March 4, 2003Date of Patent: June 8, 2004Inventors: James P. Kohler, Nancy S. Chu
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Publication number: 20040101435Abstract: A system for irradiating mail, comprising a device for conveying mail along a predetermined path and a device for irradiating the mail moving along the path with a beam of electrons. An apparatus for chilling the mail is provided along the path. The apparatus exposes the mail to a low-temperature, gaseous fluid created using a cryogenic fluid.Type: ApplicationFiled: November 27, 2002Publication date: May 27, 2004Applicant: STERIS Inc.Inventors: Michael A. Centanni, Mark Kusner
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Publication number: 20040096354Abstract: An ozone deodorizing/sterilizing device is proposed which includes an air pump for supplying pressurized air, an ozone generator for producing ozone by silent discharge, and an ozone spray device having a spray nozzle for atomizing water with the pressurized air containing ozone as a driving fluid and spraying it with air. The spray nozzle is formed to atomize water by setting the nozzle hole diameter so that water will be atomized into ultrafine volatile fog drips and fog drips will be sprayed within a predetermined range from the spray nozzle and the target space to be sterilized will be kept from getting wet.Type: ApplicationFiled: November 18, 2002Publication date: May 20, 2004Inventors: Shinnosuke Nomura, Naoya Kitamura
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Patent number: 6730238Abstract: A method for producing stable atmospheric pressure glow discharge plasmas using RF excitation and the use of said plasmas for modifying the surface layer of materials. The plasma generated by this process and its surface modification capability depend on the type of gases used and their chemical reactivity. These plasmas can be used for a variety of applications, including etching of organic material from the surface layer of inorganic substrates, as an environmentally benign alternative to industrial cleaning operations which currently employ solvents and degreasers, as a method of stripping paint from surfaces, for the surface modification of composites prior to adhesive bonding operations, for use as a localized etcher of electronic boards and assemblies and in microelectronic fabrication, and for the sterilization of tools used in medical applications.Type: GrantFiled: December 7, 2000Date of Patent: May 4, 2004Assignee: The Boeing CompanyInventors: Kin Li, Minas Tanielian
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Publication number: 20040067157Abstract: Methods are disclosed for sterilizing biological products to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas and parasites.Type: ApplicationFiled: June 10, 2003Publication date: April 8, 2004Applicant: Clearant, Inc.Inventors: Martin J. MacPhee, Randall S. Kent, Edward A. Horton, Dawson Beall
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Publication number: 20040047762Abstract: To provide a method for sterilizing a packaging material and a sterilizer used therefor, which do not cause unevenness in the sterilization effect, and uses high voltage pulses permitting to improve the sterilization effect. The purpose can be achieved by using such a discharge side electrode as is provided with unevenness having continuous projections on the discharge side surface, in the method in which the sterilizer is provided with a power source for generating high voltage, a discharge side electrode to which the high voltage generated by the power source is applied, and a ground side electrode arranged so as to be opposed to the discharge side of the discharge side electrode, and sterilizes a packaging material to be sterilized by placing it between both electrodes under normal temperature and normal pressure, and applying the high voltage pulses thereto in a gas atmosphere.Type: ApplicationFiled: June 20, 2003Publication date: March 11, 2004Inventors: Satoshi Masaoka, Hideo Hasegawa
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Publication number: 20040048371Abstract: A method is provided for sterilizing and/or deactivating adventitious agent(s) on and/or within a biological material which comprises packaging the biological material, altering the original atmosphere associated with the biological material in order to reduce the level of oxygen to which the biological material is exposed and subjecting the packaged biological material with its altered atmosphere to irradiation.Type: ApplicationFiled: July 7, 2003Publication date: March 11, 2004Inventor: Lawrence A. Shimp
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Patent number: 6702984Abstract: An apparatus and method of decontaminating surfaces on a living creature. A beam of electrons is generated with an electron beam generator operating in the range of about 40 kv to 60 kv. The beam of electrons exit the electron beam generator through an exit window. The surfaces on the living creature are irradiated with the beam of electrons. The beam of electrons are of an energy sufficient to decontaminate the surfaces without damaging living tissue.Type: GrantFiled: December 13, 2001Date of Patent: March 9, 2004Assignee: Advanced Electron Beams, Inc.Inventor: Tzvi Avnery
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Patent number: 6696018Abstract: A sterilization system seals a first end portion of a first tube and a second end portion of a second tube under sterile conditions. The sterilization system includes a sterilization chamber and an electron gun which generates a distribution of electrons in the sterilization chamber. The sterilization system further includes a spindle and a holder which places and rotates a connector in the distribution of electrons. The sterilization system further includes first and second tube holders each having curved walls movably coupled to the sterilization chamber to move between a first position where the respective end portion is separated from the connector and a second position where the respective end portion is coupled to the connector. Each curved wall has a shape such that x rays generated within the sterilization chamber undergo at least three interactions with the curved walls before propagating outside the tube holders.Type: GrantFiled: November 14, 2001Date of Patent: February 24, 2004Assignee: Electron Process Company, LLCInventor: Brad Buchanan
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Patent number: 6696060Abstract: Methods are disclosed for sterilizing preparation of monoclonal immunoglobulins to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas, prions and parasites.Type: GrantFiled: June 14, 2001Date of Patent: February 24, 2004Assignee: Clearant, Inc.Inventors: Teri Grieb, Wilson H. Burgess, William N. Drohan, Ren-Yo Forng, Martin J. MacPhee, David M. Mann, Anna McBain
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Patent number: 6692679Abstract: A method is provided for forming a plastic prosthesis bearing, net-shape bearing, near net-shape bearing or plastic stock from which such a bearing can be formed. The method includes the steps of providing plastic resin in powdered form, subjecting the powdered resin to irradiation to cross-link the resin, and molding the irradiated powder. The irradiated powder is molded by applying heat and pressure to form the powder into a desired solid plastic shape, the heating being sufficient to melt the powder.Type: GrantFiled: June 8, 1999Date of Patent: February 17, 2004Assignee: DePuy Orthopaedics, Inc.Inventors: Donald E. McNulty, Todd Smith
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Patent number: 6685883Abstract: A method and unit sterilizing sheet packaging material for producing sealed packages of pourable food products, the method including the step of directing on to opposite faces of the packaging material respective low-voltage electron beams, each having an energy of at most 100 keV. The unit includes generating devices for generating the low-voltage electron beams.Type: GrantFiled: April 5, 2001Date of Patent: February 3, 2004Assignee: Tetra Laval Holdings & Finance S.A.Inventors: Roberto Schianchi, Håkan Möller, Lars Näslund
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Patent number: 6682697Abstract: The present invention relates generally to the sterilization and disinfection of agricultural and botanical products such as botanical powders. More particularly, the present invention is directed towards the use of HBS technology whereby contaminated agricultural products are contacted, at ambient pressure, with an oxidant such as nascent oxygen or hydroxyl radicals thus resulting in the oxidization and destruction of the contaminating microorganisms.Type: GrantFiled: January 15, 2002Date of Patent: January 27, 2004Assignee: Pure World Botanicals, Inc.Inventors: Kan He, Baoliang Cui, Zhong Guan Shao, Natalie I. Koether, Val Madis, Qun Yi Zheng
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Patent number: 6669901Abstract: The invention relates to a method for treating an aqueous flow colonised by cells by applying a pulsed electric field, the intensity of the field being less than 1 kV/cm. It also relates to the application of this method to eliminating Legionella and to a method for destroying Legionella.Type: GrantFiled: October 15, 2001Date of Patent: December 30, 2003Assignee: Centre National de la Recherche ScientifiqueInventors: Nathalie Eynard, Pierre-Andrè Cabanes, Justin Teissie
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Patent number: 6667007Abstract: A method of sterilization of a container is provided whereby a cold plasma is caused to be disposed near a surface to be sterilized, and the cold plasma is then subjected to a pulsed voltage differential for producing energized ions in the plasma. Those energized ions then operate to achieve spore destruction on the surface to be sterilized. Further, a system for sterilization of a container which includes a conductive or non-conductive container, a cold plasma in proximity to the container, and a high voltage source for delivering a pulsed voltage differential between an electrode and the container and across the cold plasma, is provided.Type: GrantFiled: June 7, 2002Date of Patent: December 23, 2003Assignee: The Trustees of Princeton UniversityInventor: John A. Schmidt
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Patent number: 6627150Abstract: The present invention relates to a process for sterilization of medical instruments by concentrating a sterilant such as hydrogen peroxide inside of a sterilizer and sterilizing articles therewith. This concentrating process is monitored by determining the concentrations of water and peroxide in the chamber.Type: GrantFiled: December 29, 1999Date of Patent: September 30, 2003Assignee: Ethicon, Inc.Inventors: Jenn-Hann Wang, Paul Jacobs, Szu-Min Lin