Structure For Contacting The Sample With The Reagent Patents (Class 422/408)
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Patent number: 8940538Abstract: The present invention relates to an apparatus for quantifying the binding and dissociation kinetics of molecular interactions of small molecular bio materials with high sensitivity almost without the influence of a change in the reflective index resulting from a buffer solution by making polarized incident light incident on the binding layer of a bio material, formed in a thin dielectric film, so that the polarized incident light satisfies a p-wave non-reflecting condition and a quantifying method using the same.Type: GrantFiled: October 29, 2010Date of Patent: January 27, 2015Assignee: Korea Research Institute of Standards and ScienceInventors: Hyun Mo Cho, Gal Won Che, Yong Jai Cho
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Patent number: 8938973Abstract: An aircraft air system includes a gas turbine engine, a bleed air duct directing compressed air bled from a compressor to an inner compartment within the aircraft, and an air contamination detector located downstream of the gas turbine engine compressor. The air contamination detector includes a visual indicator which detects the presence of a fluid contaminant within the bleed air.Type: GrantFiled: February 11, 2010Date of Patent: January 27, 2015Assignee: Pratt & Whitney Canada Corp.Inventors: Kevin Allan Dooley, Kiritkumar Patel
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Patent number: 8940237Abstract: An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide. The light guide test sensor is adapted to be used to test the level of an analyte in a biological fluid sample when used with a readhead. A method of manufacturing the light guide test sensor involves providing a plurality of light guides, providing a strip of reagent-coated membrane, and providing a strip of mesh layer. The reagent-coated membrane and mesh layer are attached to the light guides by ultrasonic welding. The reagent-coated membrane and mesh layer may also be attached to the light guides by adhesive.Type: GrantFiled: January 22, 2013Date of Patent: January 27, 2015Assignee: Bayer HealthCare LLCInventors: Jeffery S. Reynolds, Steven C. Charlton, Sung-Kwon Jung, Suny J. George
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Patent number: 8940246Abstract: A system for diagnostic testing may include a meter for performing a diagnostic test on a sample applied to a test media, the meter having a housing and an interface for receiving a signal representing coding information, and a container configured to contain test media compatible with the meter, the container having a coding element associated therewith. Additionally, the system may provide a mechanism for removing the meter from an interconnected test container and reattaching it to a new container using on-container coding methods that can recalibrate the meter for the new container of test strips.Type: GrantFiled: November 1, 2007Date of Patent: January 27, 2015Assignee: Nipro Diagnostics, Inc.Inventors: Gary T. Neel, Brent E. Modzelewski, George R. Rounds, Carlos Oti, Allan Javier Caban, Jeffrey Akins
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Patent number: 8940540Abstract: A portable, hand-held glucose testing device includes a housing configured to accommodate a plurality of test sensors in a stacked arrangement and having a wall with an opening defined therein. A plurality of packaged test sensors is stacked in alignment with one another within the housing. Each of the test sensors is packaged within a blister package. The blister package includes a blister package housing and a cover foil overlying a surface of the blister package housing and the test sensor. A drive slide is configured to displace one of the plurality of packaged test sensors out of alignment with other packaged test sensors. A knife mechanism is configured to pierce through the cover foil, and to engage and urge the test sensor to extend through the opening for receiving a sample. A meter contact is configured to engage the test sensor when the test sensor extends through the opening.Type: GrantFiled: March 12, 2013Date of Patent: January 27, 2015Assignee: Bayer HealthCare LLCInventors: Steven C. Charlton, Allen Brenneman
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Patent number: 8940248Abstract: A kit comprising a carrier and vessels arranged on the carrier, wherein different reagents are contained in different vessels, the vessels are arranged with an openable closing device on top of the carrier, the carrier has a footprint on the bottom side for being placed on a base, and the carrier has bottom positioning means for being positioned on at least one workplace of an automated laboratory system for microtiter plates according to the SBS standard.Type: GrantFiled: April 29, 2013Date of Patent: January 27, 2015Assignee: Eppendorf AGInventors: Judith Lucke, Jens-Peter Kroog, Helmut Knofe
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Patent number: 8932538Abstract: A apparatus for analyzing sample to prevent a sample from being stuck to a surface of the apparatus for analyzing sample in the course of being injected into the apparatus for analyzing sample. The apparatus for analyzing sample includes a platform having a disk shape. The platform includes chambers and channels, a sample inlet hole which is formed in an outer surface the platform and through which a sample is injected into the platform; an opening which is formed in the outer surface of the platform and through which a residual of the sample, present on the outer surface of the platform around the sample inlet hole, is introduced into a receiving space isolated from the chambers and channels; and a barrier which is formed on the outer surface of the platform around a portion of the opening to prevent the residual of the sample from moving past the opening in a radial outward direction of the platform.Type: GrantFiled: January 14, 2011Date of Patent: January 13, 2015Assignee: Samsung Electronics Co., Ltd.Inventors: Hyun Min Kim, Do Gyoon Kim, Jong Myeon Park
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Patent number: 8920748Abstract: The present invention relates to a biochip with a piezoelectric element for ultrasonic standing wave generation. The biochip comprises an upper module, a lower module, and a chemical sensor. The piezoelectric element is integrated within the upper module of the biochip. The piezoelectric element can generate ultrasonic standing waves (USW) in the reaction chamber of the biochip by manipulating the operation frequency so the particles being detected can effectively move toward the QCM sensing surface. Hence, the biochip significantly increases the sensitivity and reduces the time required to reach equilibrium when undergoing USW excitation. The biochip of the present invention can be broadly applied to the bio-detection in medical and pharmaceutical fields.Type: GrantFiled: May 2, 2011Date of Patent: December 30, 2014Assignee: National Chung Cheng UniversityInventors: Guo-Hua Feng, Lai-Kwan Chau, Shu-Xiang Yang
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Patent number: 8920857Abstract: A system and method for a beverage container configured to test for a contaminated beverage in the beverage container comprises a base of the beverage container, an upper portion of the beverage container, and a sidewall with an inner surface and an outer surface that extends from the base to the upper portion, and a testing material. A portion of the beverage container is the testing material configured to visibly react when the portion of the beverage container is contacted with the contaminated beverage.Type: GrantFiled: August 7, 2011Date of Patent: December 30, 2014Inventors: Michael T. Abramson, John C. MacDonald
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Patent number: 8916108Abstract: A vial and particles for distributing reagent bound particles in a fluid, a kit, and methods for distributing particles in a fluid.Type: GrantFiled: May 17, 2012Date of Patent: December 23, 2014Assignee: Biokit S.A.Inventor: Joan Francesc Guasch
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Patent number: 8906702Abstract: A fluidic device including a main channel, wherein a first inlet fluidly connects to an upstream end of the main channel and introduces magnetic beads into a first side of the main channel A second inlet is fluidly connected to the upstream end of the main channel and introduces a sample stream into a second side of the main channel A first magnet disposed adjacent to the second side of the main channel pulls the magnetic beads towards a sidewall of the second side, and thus into the sample stream A second magnet disposed downstream from the first magnet and adjacent to a first side of the main channel subsequently pulls the magnetic beads towards a sidewall of the first side, and thus out of the sample stream A detection region is disposed at or downstream from the second magnet and in the first side of the main channel.Type: GrantFiled: March 31, 2009Date of Patent: December 9, 2014Assignee: Rutgers, The State University of New JerseyInventors: Jeffrey Zahn, Lawrence Anthony Sasso, Jr.
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Patent number: 8900875Abstract: A method for assessing a corrosion inhibitor in a coolant, comprises providing a test kit comprising a first chamber containing an acid buffer and a solvent immiscible therein and a second chamber containing an indicator, the second chamber being in fluid communication with the first chamber and being configured such that retraction of the second chamber draws fluid into the first chamber and advancement forces fluid into the second chamber; drawing a coolant sample into the first chamber; contacting the coolant sample with the acid buffer and solvent in the first chamber and extracting the corrosion inhibitor into the solvent; allowing the solvent and buffer to separate in the first chamber; forcing a portion of the separated solvent into the second chamber; contacting the separated solvent with the indicator in the second chamber, and obtaining a visual indication of the presence of corrosion inhibitor in the coolant sample.Type: GrantFiled: December 14, 2009Date of Patent: December 2, 2014Assignee: Shell Oil CompanyInventors: Abraham Robert De Kraker, Liliana Minevski, Tze Lee Phang
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Patent number: 8895320Abstract: A device and method for filtering blood is disclosed herein. The device can filter blood and attach analytes within the blood to magnetic particles. The analytes can then be strongly bound to an analyzing device by a magnetic force. The analytes can then be counted by the analyzing device and the result can be displayed.Type: GrantFiled: May 14, 2012Date of Patent: November 25, 2014Assignee: Silicon BioDevices, Inc.Inventor: Octavian Florescu
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Patent number: 8883489Abstract: Apparatus for performing an assay to detect the presence of an analyte in a test sample. A housing defines a slot for receiving a sample collector, and a capsule contains a buffer liquid, the capsule being sealed by an openable lid, and being connected to the housing such that insertion of a sample collector into the slot causes the lid to open releasing the buffer liquid into the slot. The housing further defines an incubation chamber containing or configured to receive a reagent, and an aperture permitting liquid communication between said slot and the incubation chamber. The apparatus comprises one or more test elements, a substantially liquid tight sealing member separating the incubation chamber and the test element(s), and an activation mechanism operable to open said liquid tight sealing member thereby bringing at least a portion of the or each test element into liquid communication with said incubation chamber.Type: GrantFiled: May 16, 2011Date of Patent: November 11, 2014Assignee: Concateno UK LimitedInventors: Alan Pang, Gordon Jowett, Barry Lillis, Jack Fairbank
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Patent number: 8865088Abstract: Disclosed is an assay device for use in the determination of the presence of at least one analyte of interest in a liquid sample; the device comprising a reaction zone in which a reagent reacts with the analyte of interest and a bibulous member which, when contacted with the liquid sample, draws liquid therefrom towards the reaction zone; the bibulous member comprising means to change color when wetted by the sample.Type: GrantFiled: January 9, 2003Date of Patent: October 21, 2014Assignee: Alere Switzerland GmbHInventors: Barry Sinclair Brewster, Susan Catrin Day, Peter John Skelly, Jill Crawford
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Patent number: 8865071Abstract: A test tape device is disclosed herein for use with a replaceable analytical tape cassette, where the device includes a housing having a cassette compartment covered by a cassette door and a housing opening for sample application, a protective cover that can be moved between a closed position covering the housing opening and a release position allowing access to the housing opening and a door lock for retaining the cassette door in the closed position, wherein the protective cover is coupled with the door lock via an interlocking mechanism, such that the door lock can only be unlocked in the release position of the cover.Type: GrantFiled: June 5, 2013Date of Patent: October 21, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Hao-Chih Lin, Wen Tsung Wang
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Patent number: 8834946Abstract: A system and method for a beverage container configured to test for a contaminated beverage in the beverage container comprises a base of the beverage container, an upper portion of the beverage container, and a sidewall with an inner surface and an outer surface that extends from the base to the upper portion, and a testing material. A portion of the beverage container is the testing material configured to visibly react when the portion of the beverage container is contacted with the contaminated beverage.Type: GrantFiled: February 24, 2012Date of Patent: September 16, 2014Assignee: Drinksavvy, Inc.Inventors: Michael T. Abramson, John C. MacDonald
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Patent number: 8795500Abstract: In one example embodiment, a micro-particle sorting apparatus includes: (a) a microchip in which a flow path through which liquid containing a micro particle flows and an orifice through which the liquid flowing through the flow path is discharged into a space outside the chip; (b) an oscillating element for transforming the liquid into a liquid drop and discharging the liquid drop at the orifice; (c) a charge means for adding an electric charge to the discharged liquid drop; (d) an optical detection means that detects an optical property of the micro particle flowing through the flow path, upstream of a liquid-delivering direction with respect to the orifice; (e) paired electrodes opposed to each other while sandwiching the moving liquid drop along a movement direction of the liquid drop discharged into the space outside the chip; and (f) two containers that collect the liquid drop passing between the paired electrodes.Type: GrantFiled: February 9, 2010Date of Patent: August 5, 2014Assignee: Sony CorporationInventor: Masataka Shinoda
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Publication number: 20140199768Abstract: A device indicates the location of an air leak in a vacuum bag used to process composite parts. The device includes a layer of material on the inner face of the bag that changes in appearance due to an oxidation-reduction reaction in areas of the layer exposed to oxygen caused by a leak in the bag.Type: ApplicationFiled: March 18, 2014Publication date: July 17, 2014Applicant: The Boeing CompanyInventors: John N. Harris, Finley Miller, Michael R. Swift
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Publication number: 20140193894Abstract: A fluid sensor comprises a formed plastic body and a reagent. The body has a top face with an integral first surface. The body also has a bottom face opposed to the first surface and a sidewall that extends from the periphery of the top face. The first surface is adapted to accept a fluid sample. The reagent is disposed on the integral first surface and causes a color change detectable on the bottom face when the reagent reacts with an analyte in the fluid sample.Type: ApplicationFiled: March 10, 2014Publication date: July 10, 2014Applicant: Bayer Healthcare, LLCInventors: Sung-Kwon Jung, Steven C. Charlton, Suny J. George, Andrew J. Dosmann, Karen L. Marfurt
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Patent number: 8747747Abstract: A reader for mechanical actuation of fluids within a test cartridge. The instrument interface including multiple independently-controlled plungers aligned to respective fluidic pouches on a test cartridge that is inserted into a testing apparatus embodying the instrument interface. The plungers include tips for applying mechanical force to the respective fluidic pouches.Type: GrantFiled: December 20, 2011Date of Patent: June 10, 2014Assignee: Abbott Point of Care Inc.Inventor: Seth Hunter
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Patent number: 8709736Abstract: The present invention relates to the use of TFF3 in the diagnosis and detection of Barrett's esophagus using non-invasive, non-endoscopic methods.Type: GrantFiled: July 9, 2010Date of Patent: April 29, 2014Assignee: Medical Research CouncilInventors: Pierre Lao-Sirieix, Rebecca C. Fitzgerald
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Patent number: 8703061Abstract: The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an integrated modular unit and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. The integrated modular unit includes an analyte-concentrator-microreaction device connected to a modified cartridge-cassette.Type: GrantFiled: June 4, 2012Date of Patent: April 22, 2014Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: 8697009Abstract: The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.Type: GrantFiled: September 6, 2013Date of Patent: April 15, 2014Assignee: Micronics, Inc.Inventors: Patrick Saltsman, Mingchao Shen, Jeffrey M. Houkal, Christy A. Lancaster, C. Frederick Battrell, Bernhard H. Weigl
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Patent number: 8691162Abstract: A biomedical diagnostic device includes a hydrophilic layer, hydrophobic layer, and at least one test pad. The hydrophilic layer includes an exposed introductory portion adapted to introduce a test fluid, and is stacked with the hydrophobic layer with multiple access holes. At least one test pad, each of which includes a distinguishing reaction medium, is disposed in the corresponding holes that extend to contact the hydrophilic layer. The relations within the device are as follows: hydrophilicity of any of the test pads>hydrophilicity of the hydrophilic layer>hydrophilicity of the hydrophobic layer.Type: GrantFiled: February 7, 2013Date of Patent: April 8, 2014Assignee: National Tsing Hua UniversityInventors: Shang-Chi Lin, Li-Ching Chen, Chen-Meng Kuan, Fan-Gang Tseng, Chao-Min Cheng
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Publication number: 20140093896Abstract: A point-of-care, screening kit for use by a heath care worker to create custom test strips for screening the bodily fluids of an individual for various, medical conditions includes: (a) a plurality of reagents (12), (b) a substrate (18) configured to: i) receive one of the reagents and react with it so as to cause it to acquire a first characteristic color, and, ii) upon the addition of the individual's bodily fluid to the substrate, acquire, as a result of the formulation of each of the reagents, a second, dichotomous characteristic color when the individual has a specific one of the various, medical conditions.Type: ApplicationFiled: May 7, 2012Publication date: April 3, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Sean Mongale, Shishira Nagesh, Ezra Taylor, Mary O'Grady, Thembi Mdluli, Peter Truskey, Sherri Hall, James Waring, III, Britni Crocker, Harshard Sanghvi, Elaine Yang, Soumyadipta Acharya, Maxim Budyansky, Matthew Means
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Patent number: 8673236Abstract: The invention relates to a water soluble film based matrix for collecting blood samples, urine samples, serum samples or any other type of samples extracted from living species; so as to avoid cross infection or spillage of samples during transportation of said samples. These samples can then used for further detection of virus, bacteria, finding new molecules, diagnosing genes or extraction of DNA. Also, said matrix will dissolve during analysis of the sample and thus there will be no disposal problems.Type: GrantFiled: April 25, 2007Date of Patent: March 18, 2014Assignee: Arrow Coated Products, Ltd.Inventors: Shilpan Pravinchandra Patel, Nikita Kamlesh Thanawala
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Patent number: 8667833Abstract: A protective cap 2 is engaged with a latch 10 of a diluent container 5 so as to fix the diluent container 5 at a liquid holding position of a diluent container containing section 11. The engagement is released when the protective cap 2 is set to an open position against the engagement so as to expose an inlet 13. When the protective cap 2 is shifted from the open position to a closed position, the protective cap 2 pushes the diluent container 5 into a liquid discharge position. Thus, it is possible to preserve a diluent for a long period of time and to easily open the diluent container 5 without having to complicate the structure of an analysis apparatus.Type: GrantFiled: October 27, 2008Date of Patent: March 11, 2014Assignee: Panasonic CorporationInventors: Hiroshi Saiki, Yoshiyuki Fujii, Nobuyasu Higashi, Masaaki Kitoh, Kenji Okada, Hirofumi Sugimoto
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Publication number: 20140065030Abstract: The present invention is directed toward a colorimetric detection kit comprising a unit containing chemical reagents and a sample collector for collecting a sample analyte from a surface and a separate unit for visualizing a possible reaction of the chemical reagent and sample, the unit holding the chemical reagents and sample collector being placeable on the visualization unit, whereby when the chemical reagents are released, they are directed onto the sample collector for reaction and the reacted reagents absorbed on a visualization media, such that the presence of a specified analyte in the sample results in a color change in the visualization media.Type: ApplicationFiled: October 23, 2012Publication date: March 6, 2014Applicant: U.S. Army Research Development and Engineering CommandInventor: U.S. Army Research Development and Engineerin
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Patent number: 8663561Abstract: An automated apparatus and method for analyzing liquid samples by forming discrete sample aliquots (boluses) in an elongated conduit which contains a hydrophobic carrier liquid. Aliquots may be analyzed by adding at least one reagent to the sample aliquot that reacts selectively with an analyte contained therein. The reaction product, which is selective for the analyte of interest and proportional to its concentration, is measured with an appropriate detector. Intrinsic sample properties of the sample may also be measured without the need for adding chemical reagents. The invention enables simple and accurate testing of samples using time honored wet-chemical analysis methods in microliter volume regimes while producing remarkably small volumes of waste.Type: GrantFiled: February 19, 2010Date of Patent: March 4, 2014Inventor: Charles J. Patton
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Patent number: 8647588Abstract: An apparatus and method for packaging of an optical sensing fiber is disclosed. The apparatus includes a substrate with a plurality of openings, and each opening is configured for holding an optical sensing assembly. The assembly is positioned in the opening with a tip of the assembly extending through the opening to be suspended from the substrate. In addition, openings are arranged so the assembly positioned therein avoids contacting another assembly positioned therein. The apparatus can include a support member for supporting the substrate and positioning the substrate so the tip of the assembly suspended from the opening in the substrate contacts solution in one of a plurality of wells in a container adjacent to the substrate. The assembly can be configured for preparing of the optical assembly for assay. An agitation assembly for agitating the container to create flow of the solution in the container wells over an optical sensing assembly is also disclosed.Type: GrantFiled: May 4, 2011Date of Patent: February 11, 2014Assignee: Pall CorporationInventors: Michael W. Recknor, Hong Tan, Robert Zuk, Krista Leah Witte, Sae Choo, Scott Lockard
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Patent number: 8641986Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.Type: GrantFiled: October 2, 2008Date of Patent: February 4, 2014Assignee: Meso Scale Technologies, LLCInventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
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Patent number: 8632733Abstract: The present invention provides for a device and a kit for collecting body fluids. The device includes a body fluid collection portion comprising a body fluid absorbing material. The body fluid connecting portion has a free edge and is hingedly connected at the edge opposite to the free edge to a first support panel and a second support panel. A base panel is hingedly connected to the first support panel or the second support panel. In a first folded condition the body fluid collection portion is sandwiched between the first support panel and the second support panel in a substantially face contacting relationship.Type: GrantFiled: January 21, 2011Date of Patent: January 21, 2014Assignee: Labor Diagnostika Nord GmbH & Co. KGInventors: Bernhard Manz, Matthias Kuper
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Patent number: 8632730Abstract: In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.Type: GrantFiled: November 22, 2005Date of Patent: January 21, 2014Assignee: Alverix, Inc.Inventors: John F. Petrilla, Daniel B. Roitman
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Patent number: 8623665Abstract: A method for collecting and processing biological samples (e.g., fecal samples) is disclosed. The method may include obtaining a system comprising a container, a collector, and a lid. Using the collector, a user may collect a sample. The sample may be inserted within the container. The lid may be secured and the container and sample contained therewithin may be transported to a testing facility. At the testing facility, the container may be used throughout the processing of the sample. Accordingly, the risk of cross-contamination may be reduced.Type: GrantFiled: October 13, 2011Date of Patent: January 7, 2014Inventors: Val L. Poll, Steven J. Miller, Jay J. Davis, Brian T. Leishman, Joshua L. Kirk
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Patent number: 8617485Abstract: A sensor strip apparatus includes: a top plate having an entrance opening downward and a joint formed downward; a pad section including a support having a window opening downward, a reaction pad attached to the window of the support and reacting with a specimen, first and second hemolysis inhibition pads attached to the reaction pad to filter hemocytes from the specimen, a specimen pad attached to the first and second hemolysis inhibition pads to diffuse the specimen crosswise, and an adhesive film attached to the support around the first and second hemolysis inhibition pads to increase adhesion strength of the specimen pad; and a bottom plate having a second joint forcibly coupled with to the joint of the top plate, and a window configured to indentify the reaction pad through the window of the support.Type: GrantFiled: March 14, 2011Date of Patent: December 31, 2013Assignee: SD Biosensor, Inc.Inventors: Hyo Geun Lee, Hyo Lim Park, Eun Sun Song, Byung Hak Song
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Patent number: 8613892Abstract: The present disclosure provides in vitro analyte meters that include a meter portion that is moveable relative to at least one other meter portion. Embodiments include moveable meters that are integrated with in vivo analyte systems. Also provided are methods, systems and kits.Type: GrantFiled: June 30, 2009Date of Patent: December 24, 2013Assignee: Abbott Diabetes Care Inc.Inventor: Gary Ashley Stafford
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Patent number: 8609043Abstract: The present invention relates to the use of a container, made of an inorganic additive containing plastic material, for reducing physical/chemical interaction between the container and an oil, fat and/or wax containing formulation contained therein.Type: GrantFiled: August 6, 2012Date of Patent: December 17, 2013Assignee: M & P Patent AktiengesellschaftInventor: Claudia Mattern
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Patent number: 8609044Abstract: A micro vial assembly for performing microwave-assisted chemical reactions on small reaction mixture volumes is disclosed, wherein a reaction vessel (10) is sealed through a diaphragm (30) that is capped over an open end of the reaction vessel. The reaction vessel mouths in an end plane of a sleeve (20) surrounding the reaction vessel, the diaphragm being clamped for sealing the open end of the vessel by means of a cap (40) which is secured to the sleeve. The sleeve provides a radial extension of the reaction vessel in order to bridge the radial distance between a wall of the reaction vessel and other components in a system for performing microwave-assisted chemical reactions.Type: GrantFiled: December 18, 2003Date of Patent: December 17, 2013Assignee: Biotage ABInventors: Johan Ulin, Per-Gunnar Eriksson, Fredrik Ekdahl
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Patent number: 8603835Abstract: Test cells have a first sorbent strip with a sample receiving location and defining a first migration path, a distinct second sorbent strip which receives buffer solution and at least partially defines a second migration path distinct from and elongated relative to the first migration path, conjugate supported by the second strip, a test site located at a junction of the first and second strips and having an immobilized ligand-binding mechanism, and a divider which directs a first amount of the buffer to the first strip to move the sample to the test site and a second amount to the second strip to move the conjugate to the test site. The first and second migration paths have first and second lengths chosen so that ligand in the sample reaches the test site and binds to the immobilized ligand-binding mechanism prior to the conjugate reaching the test site.Type: GrantFiled: February 10, 2011Date of Patent: December 10, 2013Assignee: Chembio Diagnostic Systems, Inc.Inventor: Javanbakhsh Esfandiari
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Publication number: 20130323852Abstract: A portable, hand-held glucose testing device includes a housing configured to accommodate a plurality of test sensors in a stacked arrangement and having a wall with an opening defined therein. A plurality of packaged test sensors is stacked in alignment with one another within the housing. Each of the test sensors is packaged within a blister package. The blister package comprises a blister package housing and a cover foil overlying a surface of the blister package housing and the test sensor. A drive slide is configured to displace one of the plurality of packaged test sensors out of alignment with other packaged test sensors. A knife mechanism is configured to pierce through the cover foil, and to engage and urge the test sensor to extend through the opening for receiving a sample. A meter contact is configured to engage the test sensor when the test sensor extends through the opening.Type: ApplicationFiled: March 12, 2013Publication date: December 5, 2013Inventors: Steven C. Charlton, Allen Brenneman
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Publication number: 20130295690Abstract: A versatile drug testing device (a lateral flow diagnostic testing device) includes a flat transparent carrier with a top and a bottom with the carrier having a series of independent parallel grooves formed therein running from adjacent to the top to adjacent to the bottom of the carrier, each groove having a first opening and a second opening above the first opening therein adjacent to the bottom of the carrier, at least one drug test strip installed in one of said grooves with its absorbent pad contiguous to the openings and a cover layer attached to the carrier operable to sealing close each of said grooves whereby the bottom of the device can be immersed in a specimen of urine, body fluid, or other biological specimen to wet the pad of the at least one test strip though the ingress of the specimen though the associated openings and the test results on the test strip can be easily viewed through the transparent carrier.Type: ApplicationFiled: June 25, 2013Publication date: November 7, 2013Inventor: Jianfeng Chen
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Patent number: 8563330Abstract: The invention provides a device and method for the rapid identification of patients suspected of having thalassemia. The invention provides a test strip for the aqueous detection of thalassemia related proteins in whole blood. The test strip includes antibodies specific to the gamma 4, (?4) protein and provides easy visual discrimination between a positive result and a negative result. The invention can be used in remote or clinical settings.Type: GrantFiled: March 21, 2008Date of Patent: October 22, 2013Assignee: National Science and Technology Development AgencyInventors: Watchara Kasinrerk, Chatchai Tayapiwatana, Thanusak Tatu, Suthat Fucharoen, Sawitree Chiampanichayakul
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Patent number: 8545760Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.Type: GrantFiled: September 28, 2007Date of Patent: October 1, 2013Assignee: Sysmex CorporationInventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
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Patent number: 8541227Abstract: The inventions relates to compositions and method for determining the absolute counts of cells per unit volume of a sample. Such a method comprises: (a) providing a container containing (i) a predetermined quantity of microparticles; and (ii) a cell-binding agent; in which the microparticles are disposed in or on a matrix which adheres to at least one wall of the container such that substantially all the microparticles are thereby attached to the container; (b) adding a known volume of sample to the container; (c) determining the ratio of microparticles to cells by counting microparticles and cells in a volume of the sample; and (d) determining the absolute count of cells by multiplying the number of cells per microparticle by the concentration of microparticles in the sample.Type: GrantFiled: February 6, 2006Date of Patent: September 24, 2013Assignee: Dako Denmark A/SInventors: Nanna K Christensen, Jesper Laursen, Lars Winther
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Patent number: 8518342Abstract: The present invention relates generally to the field of analysis, for example biological analysis.Type: GrantFiled: June 24, 2005Date of Patent: August 27, 2013Assignee: BiomerieuxInventors: David Mosticone, Pascal Montes, Jean-Claude Raymond, Bruno Colin, Cecile Paris
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Patent number: 8507260Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/ matrix interface, allowing accurate sequential draining of liquid from the reservoirs.Type: GrantFiled: June 2, 2010Date of Patent: August 13, 2013Assignee: Realbio Technologies, Ltd.Inventors: Sara Alajem, Avraham Reinhartz
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Patent number: 8501111Abstract: A fast acting sensor designed to accommodate an aqueous analyte-containing sample having a volume of less than one microliter and that can be used to quantify the amount and concentration of such analyte in the sample through light reflectance or fiber-optic light reflectance. The sensor includes a storage chamber, a capillary passage, and a reaction membrane. The storage chamber acts to collect the sample and to secure such sample while it undergoes detection. The capillary passage acts to direct the sample over the reaction membrane and controls the diffusion of the sample in the storage chamber. The reaction membrane contains all of the chemicals and enzymes needed to cause a color-change reaction when contacted with the sample. The amount of analyte can be determined by light reflectance intensity with an optical measurement instrument.Type: GrantFiled: April 14, 2012Date of Patent: August 6, 2013Inventor: Tom Cheng Xu
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Patent number: 8501496Abstract: The present invention is directed immunoassay cuvettes that comprise diffusely bound and non-diffusely bound reagents for carrying out an immunoassay. The reaction and detection are carried out in the immunoassay cuvette. The immunoassay cuvette comprises a transparent front wall, a back wall, side walls, a bottom, and a top opening. The back wall of the cuvette has a substantially planar surface made of a non-porous material and comprises a capture zone having reagents non-diffusedly bound and a signal reagent zone having reagents diffusedly bound.Type: GrantFiled: October 17, 2012Date of Patent: August 6, 2013Assignee: Access Medical Systems, Ltd.Inventors: Robert F. Zuk, Hong Tan
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Patent number: 8491852Abstract: An indicator device adapted give a detectable signal when the antioxidant capacity of a sample of a mammalian wound fluid exceeds a predetermined minimum level which is characteristic of an infected wound. Also provided system for use in the diagnosis and treatment of wounds comprising the inventive diagnostic device and a wound dressing comprising at least one antimicrobial agent for selective application to infected wounds. Also provided are methods of diagnosis and treatment by means of the inventive device and system.Type: GrantFiled: April 24, 2006Date of Patent: July 23, 2013Assignee: Systagenix Wound Management (US), Inc.Inventors: Breda Mary Cullen, Rachael Clark, Philip Stephens, Ryan Moseley