Abstract: A vacuum-assisted venous drainage reservoir for cardiopulmonary bypass surgery with both hard and soft shell reservoirs. The system utilizes a wall vacuum or other source of negative pressure to create a negative pressure via a regulator within a sealed hard shell reservoir, or within a sealed housing surrounding a soft shell reservoir. The addition of a negative pressure in the venous return line enables the use of smaller cannulas suitable for minimally invasive surgery. The reservoir need not be positioned well below the patient as in conventional gravity venous drainage configurations, thus adding flexibility to the operating room layout and enabling a reduction in the extracorporeal blood prime volume needed. In one embodiment, a flexible membrane in the hard shell reservoir expands to contact the blood surface and reduce blood/air interactions. In another embodiment, a moisture trap is provided between the source of vacuum and hard shell reservoir to reduce environmental contamination.

Abstract: A hollow fiber oxygenator includes a housing defining a blood chamber between an inner core wall and an outer wall. The chamber includes at least one blood inlet and at least one blood outlet. A plurality of hollow semi-permeable fibers extend through the chamber. Each fiber has an open inlet and and an open outlet end, the ends being sealed from the chamber by sealings. The oxygenator further includes a gas inlet on one end of the chamber in communication with the inlet ends of the fibers, and a gas outlet on the other end of the chamber in communication with the outlet ends of the fibers. Blood flows into the chamber and across the exterior surfaces of the fibers to effectuate gas transfer therebetween. A partitioning wall divides the chamber into at least two sections. In one of the sections, the blood flow is co-current with the gas flow, while in another section the blood flow is counter-current with respect to the gas flow.

Abstract: A heat exchanger is provided which may be used in an integrated blood oxygenator and heat exchanger. The heat exchanger has a plurality of wave shaped sinusoidal channels on one or both sides. The heat exchanger has a cap attached at the upper end. The heat exchanger is disposed within a housing. The bottom end of the heat exchanger is bonded to the bottom end of the housing, and the upper end of the heat exchanger with the cap attached is spaced apart from the upper end of the housing. A liquid inlet and outlet are in fluid communication with the inner surface of the heat exchanger. A blood inlet and outlet are in fluid communication with the outer surface of the heat exchanger. The heat exchanger may be used with a blood oxygenating chamber. The blood oxygenating chamber contains a plurality of permeable hollow fibers which oxygenate blood flowing through the blood oxygenating chamber. The blood oxygenating chamber is in fluid communication with the outer surface of the heat exchanger and the blood outlet.

Abstract: Articles that have an antimicrobial coating containing cyanoethylated hydroxyal-kylcellulose are provided, and their use in fields where preventing microbial contamination is important, such as in the medical field, where it is critical to minimize the spread of microbes that cause infection.

Abstract: An autoimmune vaccine is provided for administration to human patients to alleviate the symptoms of autoimmune diseases such as rheumatoid arthritis. The vaccine comprises an aliquot of the patient's blood, containing, inter alia, leukocytes having upregulated expression of various cell surface markers and lymphocytes containing decreased amounts of certain stress proteins. It is produced by subjecting the blood aliquot extracorporeally to certain stressors, namely oxidizing agents, UV radiation and elevated temperature.

Abstract: In a pump-oxygenator, artificial lungs are located in a blood delivery line for adding oxygen to a blood stream flowing through the blood delivery line and removing carbonic acid gas therefrom. A plurality of sub-reservoirs are located upstream of a main reservoir to store blood therein. A plurality of sub-suction lines for blood are respectively connected to the plurality of sub-reservoirs. The pump is driven to supply a negative pressure with the main reservoir, a magnitude of which is smaller than a negative pressure induced in the sub-reservoirs so as to draw the blood from the sub-reservoirs and the blood-drawing line to the main reservoir. A controller has control sections each supplied with a negative pressure by a negative pressure source, and connected to the corresponding sub-reservoirs and the main reservoir by way of negative pressure lines so as to control the negative pressure in each of the sub-reservoirs and the main reservoir at a preset value.

Abstract: A blood handling system has a first blood handling apparatus mounted on a second blood handling apparatus with a mounting apparatus. The mounting apparatus has two primary components: a retention sleeve attached to a stem that protrudes from the lower portion of the first blood handling apparatus; and a slotted plate that is attached to a stem on the second blood handling apparatus. The retention sleeve has a track for receiving the slotted plate and a flexible tab, with a protruding tooth, that securely engages the slotted plate in a locked position. If it becomes necessary to disconnect the first blood handling apparatus from the second blood handling apparatus during surgery, the tab may be easily moved into an unlocked position, allowing the disk to slide freely out of the track so that the units can be easily separated from each other.

Abstract: A softshell blood reservoir incorporates an integral flexible cardiotomy section in which a filter/defoamer unit is supported in a semirigid cage. The reservoir also incorporates a storage section and a mixing section. The three sections can selectively communicate with each other. Cardiotomy blood is supplied to the cardiotomy section, and venous blood is supplied to the mixing section. The storage section holds varying amounts of cardiotomy blood to maintain a constant mixed blood output from the mixing section. Only the filter/defoamer unit and the mixing section need be primed.

Abstract: Blood heat exchanger apparatus with improved heat exchanged capability and improved bonding of micro-conduit heat exchange fibers. The micro-conduit comprises a plurality of elongated fibers, which may be made of a hydrophobic material such as polypropylene or polyethylene. The micro-conduit fibers may be provided as a heat exchanger micro-conduit wrapping material, wherein the micro-conduit fibers are attached to a thin flexible interconnect, such as woven netting, to maintain the fibers at predetermined and substantially parallel alignment with each other. The wrapping material is wrapped about an elongated spindle to provide a generally cylindrical heat exchange core. A shell is placed around the core to contain the heat transfer fluid which passes around the exterior of the fibers. Opposing first and second seals are created by applying potting compound between fibers proximate the spindle's first and second ends respectively.

Abstract: Pulsatile blood flow in a heart-lung machine is accomplished by pumping blood into a bladder at a constant rate, and cyclically emptying the bladder into aortic line of the heart-lung machine either by means of the bladder's own elasticity or by a mechanical compression mechanism which can be programmed to simulate the human heartbeat.

Abstract: A blood outlet manifold is provided for a membrane-type blood oxygenator made of a plurality of micro-porous fibers. The fibers have first and second ends wound into a generally cylindrical bundle. The blood outlet manifold comprises a generally cylindrical vessel having a first annular wall dimensioned to snugly overly an exterior surface of the oxygenator fiber bundle. The vessel further has a flared portion including a second annular wall radially spaced from an end portion of the exterior surface of the oxygenator fiber bundle adjacent to the second ends of the fibers. An annular blood collection chamber is defined between the exterior surface of the oxygenator fiber bundle and the second annular wall for receiving blood flowing radially outwardly from around the fibers of the oxygenator fiber bundle. A seal is provided between the end portion of the oxygenator fiber bundle and the second annular wall.

Abstract: In an apparatus for the extra-corporal treatment of blood wherein blood is supplied from a body to a vacuum bottle via a conduit and an insertion spike, the insertion spike is in communication, by way of a gas hose, with a pressure compensation bag from which a predetermined amount of gas can be supplied to the insertion spike for foaming the blood in the vacuum bottle, whereby no excess pressure can be generated in the vacuum bottle. The blood conduit further includes a quartz glass portion to permit UV irradiation of the blood while passing therethrough.

Abstract: A method for improving priming of an integrated oxygenator and heat exchanger which includes pretreating the integrated hollow fiber oxygenator and heat exchanger device with a surfactant. Pretreating the device coats the interior surfaces of the integrated hollow fiber oxygenator and heat exchanger with the surfactant, which facilitates the removal of entrapped air. An integrated hollow fiber oxygenator and heat exchanger having a surfactant coating on the interior surfaces is provided which subsequently allows for more efficient priming with an aqueous priming media.

Abstract: A transition manifold is provided for use in association with the upper end of a generally cylindrical heat exchanger fiber bundle having a plurality of vertically extending conduits with open upper ends terminating in substantially co-planar fashion. The transition manifold is specially configured for redirecting blood flowing out of the upper end of the heat exchanger fiber bundle radially outwardly around the fibers of a concentric, surrounding oxygenator fiber bundle. The transition manifold includes a generally conical wall member defining a surface which extends at a relatively flat angle with respect to a plane perpendicular to a vertical central axis of the heat exchanger fiber bundle. The surface of the conical wall member diverges away from the upper end of the heat exchanger fiber bundle in a direction moving radially outwardly from the central axis.

Abstract: Disclosed is a small-sized gas exchange apparatus of high performance having an increased gas exchange rate and a reduced priming volume, comprising a hollow fiber module M.sub.1 formed by bundling a plurality of silicone membrane hollow fibers 1 wound in the form of a twilled pattern, a housing H.sub.1 for enclosing the hollow fiber module, an internal perfusion passage and an external perfusion passage formed within the housing H.sub.1, a first inlet A and a first outlet B formed on the housing for gas or liquid for communication with the internal perfusion passage, and a second inlet C and a second outlet D formed on the housing for gas or liquid for communication with the external perfusion passage.

Abstract: A blood reservoir for the treatment and collection of blood from two different sources. The blood reservoir has a filter/defoamer core assembly comprised of a support structure disposed within an outer defoamer. A separator with an opening is located in the support structure, dividing the support structure into a first and second portions. A depth filter is located within the first portion of the support structure. The first portion of the support structure with the depth filter forms a cardiotomy blood chamber and the second portion with no depth filter forms a venous blood chamber. This filter/defoamer core assembly is placed within a clear outer shell which forms the reservoir. This outer shell has a cover with a venous blood inlet and plurality of cardiotomy inlets. The cardiotomy inlets are in fluid communication with the cardiotomy blood chamber.

Abstract: A method of increasing the nitric oxide concentration in the blood of a human, which comprises: (a) contacting from about 0.01 ml to about 400 ml of blood with a nitric oxide concentration-increasing effective amount of ozone gas and ultraviolet radiation; and (b) administering the treated blood to a human. The method of the invention is useful for treating a variety of conditions benefitted by increased blood levels of nitric oxide.

Abstract: Apparatus for processing fluids, in particular blood, includes a housing having an fluid inlet port and a fluid outlet port, with the housing being formed by an outer tube, an intermediate tube set within the outer tube for forming a first chamber therebetween, and an inner tube set within the intermediate for forming a second chamber therebetween. Disposed within the chambers are a plurality of hollow fiber membranes for suitably conducting heat exchange fluid and gas. The first and second chambers are so interconnected to one another and the inlet port and outlet ports are so disposed as to effect a fluid flow path through the chambers in longitudinal direction of the tubes.

Abstract: A blood oxygenator having a substantially cylindrical structure provided with an inner wall or core and an outer wall that define an oxygenation chamber. The oxygenation chamber contains a hollow fiber bundle comprised of hollow microporous semi-permeable fibers which are meant to be affected externally by the blood that flows in the oxygenation chamber. The oxygenation chamber is provided with inlet and outlet paths for connection to the outside. The hollow fibers are embedded, at their ends, in rings of polyurethane resin known as potting and are connected to gas inlet and outlet chambers respectively for the intake of oxygen and for the discharge of the carbon dioxide. The structure includes ribs that extend from the inner wall of the structure and are divided into multiple sets that run longitudinally along the entire length of the core generally parallel with the axis of the core.

Abstract: A combined venous and cardiotomy blood reservoir is provided that includes a rigid shell having a top, a bottom, and a continuous side wall. The top and bottom walls are connected to the continuous side walls so as to define a reservoir for venous and cardiotomy blood. A double column structure is provided within the blood reservoir, the first column for receiving and degassing venous blood, the second for receiving, filtering and defoaming cardiotomy blood. The venous blood filtering and defoaming components can include a top venous screen plate, a bottom venous screen plate or stand and a perforated venous cage captured therebetween. The venous column is of generally D-shape and has a double screen structure including an inner microscreen and an outer microscreen received respectively on the inside and outside of the perforated venous cage.

Abstract: A method is provided for priming a hollow fiber oxygenator which is integrated with a hollow tube heat exchanger. A closed priming circuit is created between a cardiosurgery reservoir, the combined hollow fiber oxygenator and heat exchanger and a vacuum source. Vacuum pressure is applied to the closed priming circuit to evacuate the residual air from the circuit. Priming solution is released from the cardiosurgery reservoir and fills the evacuated closed priming circuit.

Abstract: A blood oxygenator having a housing with an outer walled portion and a top portion and bottom portion. Blood is introduced through the bottom portion of the housing to be oxygenated by a fiber bundle having blood and oxygen flow. A blood outlet manifold in the upper portion of the housing is connected to a blood outlet on one end having a conical passage. The blood outlet manifold includes a reservoir with an increasing volume toward the conical passage and is sloped upwardly to enhance gaseous microemboli disentrainment. The wall of the housing decreases in dimension upwardly toward the blood outlet manifold, while the introduction of blood to the fibers is in a lesser ratio to the area adjacent the outlet manifold.

Abstract: The obstruction of a curved blood manifold window in a blood oxygenator by oxygenation fibers which lie along a chord of a curved window when wound upon the oxygenator core is avoided by recessing the manifold wall portions most closely adjacent the window sufficiently so that the fibers lying on that chord remain sufficiently spaced from those closest wall portions to allow blood flow between those wall portions and the closest fibers.

Abstract: Oxygen transfer to blood plasma in a blood oxygenator using a microporous membrane exposed to blood on one side and to oxygen on the other is facilitated by bonding an oxygen-carrying chemical such as hematin or a perfluorocarbon to at least the blood-contacting surface of the membrane.

Abstract: An apparatus 10 and method for delivering a high partial pressure of a gas into a liquid. The apparatus has a gas transfer device 12 with a housing 14 that includes upstream 16 and downstream 18 regions, between which there is located a gas-liquid contacting region 20 with contacting members 22, such as hollow microporous fibers. A reservoir 36 of gas supplies the gas at a high pressure (P) to a flask 38 of gas-depleted liquid and to the gas transfer device 12. The reservoir 36 of gas provides hydrostatic pressure for urging the liquid through the contacting members 22 and propelling the gas around the contacting members 22 so that the gas does not diffuse across the contacting members 22. The gas-enriched liquid is then ducted to a high resistance delivery channel 44 for administration to a site of interest without effervescence, bubble formation, or significant disruption of laminar flow.

Abstract: A low prime, high heat exchange efficiency oxygenator is provided which includes an oxygenation portion and a heat exchanger portion. Disposed within the heat exchanger portion is a hollow tube heat exchanger wound bundle which includes a plurality of hollow tubes knitted into a mat, the mat wound under tension into a bundle which includes from 16 to 24 layers of the mat. The oxygenator provided permits prime volumes of 180 to 240 mLs.

Abstract: Provided is an improved disk oxygenator having a hollow median longitudinal shaft with a plurality of orifices to allow oxygen to be diffused radially through a cylindrical reservoir. Also provided is a disk oxygenator with a hollow longitudinal shaft comprised of a series of disks. The disks are provided with a central annular cylindrical passageway.

Abstract: A photobioreactor system for efficient oxygen production for a closed ecological life support system (CELSS) is disclosed. Special features of this system include, e.g., the optical transmission system, uniform light distribution, continuous cycling of cells, gravity independent gas-exchange, and an ultrafiltration unit. The fiber optic based optical transmission system illuminates the reactor internally and includes a light source which is external to the reactor, preventing heat generation problems. Uniform light distribution is achieved throughout the reactor without interfering with the turbulent regime inside. The ultrafiltration unit exchanges spent with fresh media and its use results in very high cell densities, up to 10.sup.9 cells/ml for Chlorella vulgaris. The prototype photobioreactor system may be operated in a batch and continuous mode for prolonged periods of time. The photobioreactor may be used to convert CO.sub.2 to oxygen in an artificial lung.

Abstract: A gas/liquid contact method and apparatus, for example, for oxygenating blood using O.sub.2 and O.sub.3. A low pressure stream of oxygen is introduced into a chamber through a spray orifice while inducing blood into the oxygen stream in a first blood/oxygen contact zone. The blood is caused to issue from the spray orifice as a dispersed low-pressure spray of blood droplets and is directed against a dome-shaped film forming surface located within the chamber in the path of spray. The droplets impinge on the surface at relatively low velocity and form a film for providing a further oxygen/blood contact zone. The apparatus may be designed to operate on a one-pass or a recirculation basis.

Abstract: An artificial lung is created by taking an animal lung, filling either its circulatory system or its respiratory system with a hardenable liquid, hardening the liquid, then dissolving the natural lung tissue, coating the hardened liquid with a material forming a gas permeable membrane, removing the hardenable fluid, and enclosing the resulting artificial lung structure in a fluid-tight pouch.

Abstract: A disposable device for filtration and collection of blood during a surgical operation, which device comprises a housing with a cup-shaped portion, in which a wall section is forming a ledge in the reservoir inside the housing. A first self-supporting filtration element for venuous blood is upstanding from the ledge, and a second filtration element for cardiotomy blood is suspended from the cover, the two elements being arranged side by side in a parallel relationship. The filter elements have an elongate, oval cross-section.

Abstract: A method of inhibiting the aggregation of blood platelets in a human, which comprises: (a) contacting from about 0.01 ml to about 400 ml of blood with a blood platelet aggregation-inhibiting effective amount of ozone gas and ultraviolet radiation; and (b) administering the blood treated in step (a) to a human. A method of stimulating the immune system, and of treating immune system disorders, by treating blood with ultraviolet radiation and ozone gas, followed by administering the treated blood to a human.Also disclosed is a method of treating Raynaud's Disease by contacting about 0.01 ml to about 400 ml of human blood with a blood platelet aggregation-inhibiting effective amount of ozone gas in admixture with oxygen gas, and ultraviolet radiation, while maintained at a temperature in the range of from about 37.degree. C. to about 43.degree. C. for a period for about 0.5 minutes to about 10 minutes, and administering the blood so treated to a human patient with Raynaud's Disease.

Abstract: A system which provides information necessary to diagnose a failure or malfunction of an oxygenator. The system provides information to differentiate oxygenator failure from other causes of hypoxemia (inadequate blood oxygen concentration). Such as malfunction of the ventilating circuit, or components of the ventilating circuit. This is accomplished by analyzing the oxygen concentration of the ventilating gas entering the oxygenator, the flow of the ventilating gas entering the oxygenator, and also the pressure in the ventilating gas circuit or the pressure of gas within the oxygenator. As a result the invention provides information to diagnose ventilating gas flow obstruction or a gas leak from an oxygenator housing.

Abstract: The blood flow channel sections of an oxygenator and a blood resevoir are hydrophilized by treatment with an acid, an albumin solution, polyhydroxy methacrylate, corona discharge, plasma or ozone, so that it has highly improved weltability by the priming liquid and the blood to prevent blood foaming. The blood flow channel sections of a medical instrument may be additionally hydrophilized by treatment with a polymer containing hydroxyethyl methacrylate and methyl methacrylate or in addition thereto a poly(oxyethylene)-poly(oxypropylene) block polymer.

Abstract: A method of injecting gas-supersaturated fluids as a bubble-free effluent from a delivery system into a relatively low pressure, gas-depleted environment without cavitation or bubble formation. The method includes the steps of eliminating cavitation nuclei from within the delivery system, compressing a fluid and a gas at a high partial pressure to form a gas-supersaturated fluid, and ejecting the gas-supersaturated fluid through the delivery system into the environment without associated cavitation formation in the effluent.

Abstract: An intravenous fiber membrane oxygenator is disclosed in several embodiments wherein the fibers either run at a transverse angle relative to the longitudinal axis of the oxygenator and/or are of a reduced length to optimize the gas transfer efficiency of the oxygenator. Various helical or spiral wraps of fibers are disclosed. One embodiment utilizes two sets of longitudinally extending fibers wherein the oxygen gas is moved in opposite directions from a central location of the oxygenator.

Abstract: The blood flow channel sections of an oxygenator and a blood resevoir are hydrophilized by treatment with an acid, an albumin solution, polyhydroxy methacrylate, corona discharge, plasma or ozone, so that it has highly improved wettability by the priming liquid and the blood to prevent blood foaming. The blood flow channel sections of a medical instrument may be additionally hydrophilized by treatment with a polymer containing hydroxyethyl methacrylate and methyl methacrylate or in addition thereto a poly(oxyethylene)-poly(oxypropylene) block polymer.

Abstract: A reservoir for use in an extracorporeal blood circuit including a rigid shell forming an enclosed reservoir. A filter unit divides the reservoir into an inlet chamber and outlet chamber. Cardiotomy blood filtering and defoaming means and venous blood filtering and defoaming means are located within the inlet chamber.

Abstract: An apparatus for exchanging substances, such as artificial lung, in which, for raising exchange efficiency by feeding liquid to the outer wall of hollow fiber membranes efficiently without channeling and for reducing the size of the apparatus, an exchanging part comprising a multitude of hollow fiber membrane (3) disposed cylindrically or annularly to permit liquid to flow through the hollow parts is provided, and a pump (P) is disposed on the inner periphery of said exchanging part so that liquid may continuously be fed to the hollow membrane vertically with respect to the axial direction of said hollow fiber membrane (3).

Abstract: A membrane oxygenator is disclosed. The oxygenator has a housing, gas and blood inlets and outlets, and a transfer membrane mechanism for transferring oxygen to blood. The oxygenator has a device for increasing its efficiency. The device maintains the total pressure of the oxygenating gas at each point within gas flow paths near yet below the total pressure of the blood opposite the transfer membrane mechanism generally throughout the oxygenator. The mechanism restricts the flow of oxygenating gas exiting through a oxygenating gas outlet with approximately the pressure of blood exiting through a blood outlet by providing a pressurization fluid with approximately the pressure of the blood exiting through the blood outlet. In a preferred embodiment, the oxygenating gas outlet is situated within the hollow portion of the housing.

Abstract: An oxygenation apparatus for introducing a flow of oxygen gas molecules into a carrier liquid in a one-pass operation comprises a receiving chamber for receiving carrier liquid, a contacting chamber for allowing the oxygen gas molecules to thoroughly contact the carrier liquid, and a separating partition located between the receiving chamber and the contacting chamber so as to preclude the return of oxygenated carrier liquid from the contacting chamber to the receiving chamber. There is an inlet for introducing oxygen gas molecules at a pressure slightly above the ambient surrounding air pressure into the apparatus, which terminates in an end portion having a gas introduction orifice. The gas introduction orifice is located in fluid communication with the receiving chamber, and causes a jet of oxygen gas molecules to be emitted therefrom.

Abstract: Medical equipment for use in for example measurement of hematocrit and oxygen saturation in blood in which a connector portion includes protuberances to draw the portion relatively toward a probe, a window to cooperate with the probe, and a ramp and slot to cooperate with the probe to selectively limit its rotation.

Abstract: A membrane oxygenator designed to provide blood flow evenly across a gas permeable membrane in a direction substantially perpendicular to the longitudinal direction of the gas permeable membrane. In particular, the present invention is directed to a membrane oxygenator wherein the blood is distributed substantially evenly and at a substantially constant velocity, in a cross-wise direction across the gas permeable membrane. In accordance with a preferred embodiment, the membrane is a bundle of gas permeable hollow fibers with the blood being distributed in a direction substantially perpendicular to the longitudinal direction of the individual hollow fiber membranes.

Abstract: A gas transfer apparatus readily adapted for oxygenating blood includes a housing with a hollow internal chamber having a fiber mat consisting of two sets of intermingled hollow fibers with one set of fibers having micropores formed in the walls thereof and the other set having solid liquid impermeable walls. The housing for the apparatus is designed such that the blood being processed passes substantially uniformly across the entire cross section of the fiber mat whereby a treating gas such as oxygen being directed through the microporous fibers can be diffused into the oxygen deficient blood while excess CO.sub.2 in the blood can cross diffuse into the interior of the fiber and be removed from the apparatus. Simultaneously with the cross diffusion of gas between the microporous fibers and the blood, a thermal conducting fluid such as water is passed through the solid walled fibers to maintain or regulate the temperature of the blood in the apparatus.

Abstract: A blood oxygenator/heat exchanger system includes disposable and durable components, the latter being possible of permanent installation to further reduce costs, inconvenience and risks of use. The system may selectively include a blood pump of axial, centrifugal, or ventricular type, along with an integral venous reservoir. By combination, arrangement and cooperation of structural features blood pumping volume is decreased, advantageous blood flow paths are achieved, blood damage is reduced, and durable components are reusable for lowest costs. The oxygenator/heat exchanger nests upon a durable heat source base to be supported thereby, while redundant boundaries are provided between blood and heat transfer media.

Abstract: A low priming volume integrated centrifugal pump and membrane oxygenator comprising a housing containing a mass transfer bed comprising gas permeable hollow membrane fibers placed circumferentially in a ring around an impeller. The mass transfer bed is formed by a multiple wrap of a fiber ribbon comprising at least two layers of fibers bonded in precise orientation with fibers in alternate layers are positioned in line with the opening between fibers in the layers above and below. Adhesion means ensure precise orientation of the fibers. Priming volume is further reduced by a small impeller flow channel volume.

Abstract: The present invention relates to apparatus for transferring constituents into and out of a fluid such as blood. The apparatus includes a biphasic foam body which functions as a blood oxygenator, blood dialyzer, or other blood mass transfer device.

Abstract: A blood reservoir has a blood storage section for temporarily storing blood, a blood discharge port defined in a bottom of the blood storage section for discharging the blood, the blood discharge port being displaced from a central portion of the blood storage section, and at least one partition disposed substantially vertically in the blood storage section for suppressing resonant suppression of a surface level of the stored blood upon pulsative blood discharge from the blood storage section.

Abstract: A defoaming device for separating foam and bubbles from a liquid, such as blood, is disclosed. The device can be used in conjunction with a medical device, such as a membrane oxygenator, for separating air from blood while minimizing blood contact with the antifoam agent used in the device. In a first embodiment, the device includes a reservoir and a filtering material that does not contain any antifoaming agent. This filtering material is positioned in a lower portion of the reservoir to separate foam and bubbles from the liquid. An element containing an antifoaming agent is positioned in the reservoir above the maximum surface fluid level therein and receives the foam and bubbles that rise from the filtering material. Contact of the liquid with the antifoaming agent is substantially avoided. In a second embodiment, an element containing an antifoaming agent is positioned in the reservoir within the fluid therein.

Abstract: A blood reservoir serves to remove air bubbles from blood and maintain a desired amount of blood in an extracorporeal blood circulation circuit. The blood reservoir has a blood inlet chamber having blood inlet ports, a blood storage chamber having a blood outlet port, and a blood debubblizer disposed between the blood inlet chamber and the blood storage chamber and extending the full width across the blood passage defined by the blood inlet chamber. A rib is held against the side of the debubblizer closer to the blood storage chamber and extends the full width across the blood passage, the rib having a certain height. Blood introduced into the blood reservoir is forced by the rib to stay in the debubblizer, during which time air bubbles are reliably removed from the blood by the debubblizer.