Used With Centrifuge Equipment Patents (Class 422/548)
  • Patent number: 10252267
    Abstract: Provided is a rotatable microfluidic device for conducting simultaneously two or more assays. The device includes a platform which can be rotated, a first unit which is disposed at one portion of the platform and detects a target material from a sample using surface on which a capture probe selectively binds to the target material is attached, and a second unit which is disposed at another portion of the platform and detects a target material included in the sample by a different reaction from the reaction conducted in the first unit.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: April 9, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Beom-seok Lee, Yoon-kyoung Cho, Jong-myeon Park, Jeong-gun Lee
  • Patent number: 10006076
    Abstract: The invention relates to methods and instruments for the rapid detection and rapid mass spectrometric identification of microbial infective agents in blood or other body fluids. The invention recognizes that blood is not a good environment for the cultivation of microbes and provides a method which (a) largely destroys or dissolves the human particles in body fluids, such as erythrocytes and leukocytes in blood, without impairing the ability of the microbes to reproduce, (b) separates the microbial pathogens from the fluid, (c) cultivates them in a nutrient broth which contains none of the antimicrobial components of the body fluids, (d) separates them from the nutrient broth, and (e) identifies the microbes by a mass spectrum of the microbial proteins. The dissolution of the human particles also releases the microbes nesting in macrophages.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: June 26, 2018
    Assignee: Bruker Daltonik GmbH
    Inventors: Jochen Franzen, Markus Kostrzewa, Thomas Maier, Karsten Michelmann, Wolfgang Pusch
  • Patent number: 9648669
    Abstract: A microwavable lidded container assembly comprising a container base having peripheral walls and an open top, a lid able to seat and thereby close the container base at the open top to define an enclosure; characterised in that the lid has a closable vent and the lid has a body adapted to carry a near peripheral seal to be interposed between a downward facing shoulder or plateau of the lid onto the top of a peripheral wall of the base container yet to have outstands at opposed perimeter regions of the lid to act as handle pairs for lifting the lid relative to the container base to deseat the lid therefrom.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: May 9, 2017
    Assignee: SISTEMA PLASTICS LIMITED
    Inventors: Brendan Jon Lindsay, James Richard Manley
  • Patent number: 9182384
    Abstract: An analyzing device configured to separate a solution component 18a in a separating cavity 23, which is connected to a measuring cavity through a connecting channel 37 and a measurement channel 38. A first capillary cavity 33 is provided on one side of the separating cavity 23 so as to communicate with the connecting channel 37. The first capillary cavity 33 is formed to extend to the outside of a separation interface 18c of a sample liquid separated in the separating cavity 23.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: November 10, 2015
    Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.
    Inventors: Hiroshi Saiki, Kouzou Tagashira, Hirofumi Sugimoto
  • Patent number: 9095798
    Abstract: The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation. A medium density fluid is used within the vessel to further isolate constituents of differing densities.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: August 4, 2015
    Assignee: MicroAire Surgical Instruments, LLC
    Inventors: John R. Chapman, Rodney Sparks
  • Publication number: 20150148212
    Abstract: The present invention may provide a method of removing red blood cells and a centrifuge tube for blood collection, which method and centrifuge tube can, when cells contained in blood are observed after spreading the cells, improve detection accuracy of rare cells contained in the blood, hardly causing loss of the rare cells. The method of removing red blood cells may include the steps of: (A) fixing cells contained in a blood-derived sample; and (B) subjecting the blood-derived sample obtained in the Step (A) to density gradient centrifugation to separate the sample into at least two layers, one of which contains a large amount of red blood cells and the other of which contains a large amount of cells other than red blood cells.
    Type: Application
    Filed: May 9, 2013
    Publication date: May 28, 2015
    Applicant: Konica Minolta, Inc.
    Inventors: Tsuneko Chiyoda, Koji Miyazaki, Jungo Araki
  • Publication number: 20150148255
    Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a plurality of processing vessels and a collector. The collector funnels portions of the target material from the suspension through a cannula and into the processing vessels. Sequential density fractionation is the division of a sample into fractions or of a fraction of a sample into sub-fractions by a step-wise or sequential process, such that each step or sequence results in the collection or separation of a different fraction or sub-fraction from the preceding and successive steps or sequences. In other words, sequential density fractionation provides individual sub-populations of a population or individual sub-sub-populations of a sub-population of a population through a series of steps.
    Type: Application
    Filed: January 30, 2015
    Publication date: May 28, 2015
    Applicant: RareCyte, Inc.
    Inventors: Lance U'ren, Daniel Campton, Joshua Nordberg, Steve Quarre, Jonathan Lundt
  • Publication number: 20150140597
    Abstract: The invention includes a method of determining the effective density of nanomaterial agglomerates in liquids, such as but not limited to physiological fluids, using volumetric centrifugation. The method of the invention allows for the development of reliable and efficient in vitro dosimetry and methods for toxicological testing of engineered nanomaterials.
    Type: Application
    Filed: June 20, 2013
    Publication date: May 21, 2015
    Inventors: Philip Demokritou, Glen Deloid, Joel Cohen
  • Publication number: 20150126353
    Abstract: The invention relates to a disc package for a centrifugal separator and a centrifugal separator provided with a disc package comprising a first set of separation discs and a second set of separation discs. Each separation disc of the first and second sets are provided with a separation surface with is inclined with respect to the radial direction. The separation discs of the first and second sets are arranged coaxially around an axis of rotation at a distance from each other such that to form passages between each two adjacent separation discs. The separation discs of the first set have outer diameters A or below, and the separation discs of the second set have outer diameters B or above, wherein diameter B is larger than diameter A. At least two separation discs of the first set is arranged between every two separation disc of the second set.
    Type: Application
    Filed: May 13, 2013
    Publication date: May 7, 2015
    Applicant: ALFA LAVAL CORPORATE AB
    Inventor: Peter Hagqvist
  • Publication number: 20150125436
    Abstract: The present invention is related to the field of tissue regeneration. It concerns more particularly new processes, tubes and devices for thrombin, platelet concentrate and wound healant preparations, alone or in combination with cell extracts, cell compositions and uses thereof.
    Type: Application
    Filed: January 14, 2015
    Publication date: May 7, 2015
    Inventor: ANTOINE TURZI
  • Patent number: 9012228
    Abstract: Provided is a method for checking a blood status including: a step of supplying blood to the centrifugal container of a disk; a step of rotating the disk to centrifuge the blood cells and blood plasma in the centrifuge container, and detecting the actual moving distance per hour of the blood cells in the centrifugal container; and a step of establishing a first graph which represents the actual moving distance of the blood cells per hour, and a second graph which represents the theoretical moving distance of the blood cells per hour, and thereafter calculating the hematocrit of the blood cells and the viscosity of the blood plasma by comparing the first graph with the second graph.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: April 21, 2015
    Assignee: Postech Academy-Industry Foundation
    Inventors: Dong Sung Kim, Moonwoo La, Sangmin Park
  • Patent number: 8999729
    Abstract: A device for conducting an agglutination assay comprising several reaction vessels, each reaction vessel comprising an upper chamber having an opening for accepting reactants and/or a sample; and a lower chamber comprising an end in communication with the upper chamber for receiving fluids from the upper chamber, a closed end opposite to the end, and a matrix for separating agglutinates from non-agglutinates; wherein the device further comprises a rotating support able to rotate around an axis and holding pivotally the reaction vessels in a way to allow the reaction vessels to pivot about an axis essentially perpendicular to the rotation axis of the support when the latter is rotated, such that the fluids remain in the upper chamber when the support is not rotated, and can flow from the upper chamber to the lower chamber and into the matrix when the support is rotated.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: April 7, 2015
    Assignee: Symbion Medical Systems Sarl
    Inventors: Isabelle Delafosse, Fabrice Ummel, Antonio Yanez
  • Publication number: 20150093305
    Abstract: A centrifugable device for handling fluids includes at least two bodies that are arranged axially one above the other. The at least two bodies each have at least one cavity that is configured to be fluidically coupled to the at least one cavity of the other body. The device further includes at least one fluid path, the orientation of which fluid path runs in a manner dependent on an acting Coriolis force.
    Type: Application
    Filed: September 26, 2014
    Publication date: April 2, 2015
    Inventors: Juergen Steigert, Martina Daub, Melanie Hoehl
  • Patent number: 8992862
    Abstract: A separation device including a first buoy, a second buoy, a first valve, and a second valve. The first buoy is mounted to a buoy guide post and slidably mounted within a separation chamber. The second buoy is slidably mounted to the guide post and movable between a first position and a second position. The second buoy closes the first valve and opens the second valve when in the first position. The second buoy opens the first valve and closes the second valve when in the second position. The second buoy has a density such that after spinning the device for a suitable period of time a first component of the composition is isolated between the first buoy and the second buoy and a second component of the composition is isolated between the second buoy and the end of the separation chamber that is opposite to a port.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: March 31, 2015
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Jason Chavarria
  • Publication number: 20150064687
    Abstract: A device and method for producing a portion of platelet rich plasma from a fluid sample obtained from a patient. The device comprises three intercommunicated portions, each portion having an internal chamber defined therein. The fluid sample is first brought into the base portion where it is separated into red blood cells and plasma. The plasma portion of the sample is then withdrawn into the second portion where it is further separated into platelet poor plasma disposed over platelet rich plasma. The portion of platelet poor plasma is then withdrawn from the second chamber, leaving only platelet rich plasma within the second chamber. The base portion also includes a membrane located on its distal end which helps maintain a vacuum within the device when the fluid sample is being initially inserted into base chamber.
    Type: Application
    Filed: September 2, 2014
    Publication date: March 5, 2015
    Inventor: Alexander Nemirovsky
  • Patent number: 8968682
    Abstract: A well plate includes a including a top portion, a bottom portion and a membrane disposed between the top portion and the bottom portion. The top portion defines a sample well in fluid communication with an opening defined by the membrane and in fluid communication with a reservoir defined by the bottom portion. The well plate is configured to be used in a centrifugation process of a test sample including a sample material and a wash liquid. The test sample configured to be received within the sample well and the reservoir. The membrane configured to filter the wash liquid from the test sample during the centrifugation process such that the wash liquid can pass from the reservoir, through the membrane and can be captured within a collection chamber while the sample material remains within the reservoir.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: March 3, 2015
    Assignee: Cytosaver LLC
    Inventor: Matthew Hale
  • Patent number: 8956580
    Abstract: An analysis cartridge comprising a cartridge body, a first cover, a liquid storage box and a sealing film is disclosed. The cartridge body has an accommodation portion and a first side and a second side opposite to the first side. The first cover covers the first side or the second side of the cartridge body and has a first through hole. The liquid storage box is disposed in the accommodation portion and has a liquid through hole. The sealing film seals the liquid through hole of the said liquid storage box and passes through the first through hole of the first cover, wherein the liquid through hole is exposed by removing the sealing film.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: February 17, 2015
    Assignee: Lite-On Technology Corporation
    Inventors: Cheng-Chang Lai, Fu-Chun Huang, Yuh-Jiuan Lin
  • Patent number: 8932234
    Abstract: Devices, systems, and methods for the collection of biological samples. In at least one exemplary embodiment, a device comprises a collection medium having top and bottom surfaces and a predetermined size and shape, the top surface comprising a position marker and at least one binding site operable to bind a biological sample, a protective facing substantially impermeable to the biological sample, the protective facing coupled to the top surface of the collection medium and having a size and shape substantially similar to the predetermined size and shape of the collection medium. The protective facing being sized and shaped to define a first void positioned to allow for the transfer of the biological sample through the protective facing and onto the at least one binding site of the collection medium, and a second void positioned to expose the position marker for alignment of the collection medium.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: January 13, 2015
    Assignee: Bioanalytical Systems, Inc.
    Inventors: Scott R. Peters, James M. Hampsch
  • Publication number: 20150004080
    Abstract: A biological fluid collection cup for use with a centrifuge bucket to separate a biological fluid into its component parts is disclosed. It includes an hourglass shape with a large upper and lower portion and a narrow middle portion. A piston is to slide into and slideably be received in the lower portion and a side port is provided for withdrawal of a fluid from the narrow portion.
    Type: Application
    Filed: April 1, 2014
    Publication date: January 1, 2015
    Applicant: Alliance Partners LLC
    Inventors: Emad Hassouneh, Logan White, Max Schmidt, Frank Morris, Andrew Enke
  • Publication number: 20140356254
    Abstract: Disclosed is a container for a centrifugal separator. The container for the centrifugal separator according to the present invention is characterized in that a supporting rib formed at a connection portion comes in contact with an inner circumference of an inserting hole or an inner circumference of a bucket of the centrifugal separator in which the container is inserted and supported, although a lower cover coupled with a lower receiving portion of a body falls beyond a predetermined location. Therefore, the container does not move in the radius direction even though the centrifugal separator rotates, and thus is not damaged.
    Type: Application
    Filed: November 8, 2012
    Publication date: December 4, 2014
    Inventors: Bum Ha LEE, Jung Min LEE
  • Publication number: 20140348726
    Abstract: A centrifuge container comprising a centrifuge bucket, a locking lever and a lid is disclosed. The lid is adapted to be locked on the centrifuge bucket, and the locking lever is adapted to be pivoted from an open position to a closed position. The lid and centrifuge bucket can be made to engage each other via respective connection means by means of the locking lever such that the lid will be locked in place in the closed position of the lever and will be released in the open position of the lever. The locking lever is provided in the form of a carrying handle and that carrying handle is adapted to be pivotably mounted on one carrying handle mounting unit integrally formed on the centrifuge bucket, and that the carrying handle, in its closed position, allows the centrifuge container to be carried by means of the carrying handle.
    Type: Application
    Filed: December 7, 2012
    Publication date: November 27, 2014
    Applicant: ANDREAS HETTICH GMBH & CO. KG
    Inventor: Andreas Hölderle
  • Publication number: 20140349410
    Abstract: The present invention relates to improved methods for processing fluids and to a fluid processing device (1) for use in a centrifuge comprising: (a) a first holder (14) form-fit to the shape of a first tube (18) for holding said first tube (18) whereby said first tube (18) has a first cross section (A1); and (b) a second holder (22) form-fit to the shape of a second tube (26) for holding said second tube (26) whereby said second tube (26) has a second cross section (A2) that is different from said first cross section (A1). With the fluid processing devices and the methods according to the invention, it is possible to simplify the centrifugal processing steps for a given fluid processing sequence and to automate them.
    Type: Application
    Filed: June 4, 2014
    Publication date: November 27, 2014
    Inventors: Andreas SCHAEFER, Thomas VOIT, Markus ZBINDEN, Andreas SCHMIEDE
  • Patent number: 8883095
    Abstract: An analysis cartridge and an analysis system thereof are disclosed. The analysis cartridge comprises a cartridge body, a liquid storage box and a sealing film. The cartridge body has an accommodation portion. The liquid storage box is disposed within the accommodation portion and has a liquid storage tank and a pillar receiving hole. The sealing film covers the pillar receiving hole and seals an opening of the liquid storage tank.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: November 11, 2014
    Assignee: Lite-On Technology Corporation
    Inventors: Cheng-Chang Lai, Fu-Chun Huang, Yuh-Jiuan Lin, Timothy Z. Liu
  • Patent number: 8871160
    Abstract: Provided is a biomaterial detecting device for confirming or detecting a biomaterial reaction, and more particularly to a biomaterial detecting device, which is formed in a stick type to thereby be immersed in a tube containing a biomaterial solution to be tested; has an upper portion with a cap structure to thereby induce reaction with a biomaterial, and thus facilitate confirmation and detection of the biomaterial; and is formed in a cap structure to thereby prevent evaporation of a sample and infiltration of an external material at the time of a biomaterial reaction in the tube, and thus improve reliability in analysis.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: October 28, 2014
    Assignee: K-MAC
    Inventors: Sung-Min Seo, Jae-Hyung Park, Oleksandrov Sergiy, Joong Hwan Lee, Mun-Cheol Paek, Su-Jin Ku
  • Publication number: 20140309096
    Abstract: A biological fluid separation system for a blood sample is disclosed. The biological fluid separation system includes a biological fluid collection device adapted to receive a blood sample and a centrifuge. The centrifuge is adapted to receive the biological fluid collection device such that with the biological fluid collection device received within the centrifuge and a rotational force applied to the biological fluid collection device, a plasma portion of the blood sample is separated from a cellular portion of the blood sample. The biological fluid collection device is only receivable within the centrifuge in one orientation.
    Type: Application
    Filed: April 14, 2014
    Publication date: October 16, 2014
    Inventors: Bradley M. Wilkinson, Craig A. Gelfand
  • Patent number: 8852529
    Abstract: A particle processing device includes a substrate and at least one fluidic path. The substrate is rotatable with respect to the middle region thereof. The fluidic path is provided in the substrate to extend from the middle region to a peripheral region. The fluidic path transfers a fluid having a particle from an input portion to an output portion of the fluidic pather by using a centrifugal force of the rotation of the substrate. A capturing region is formed between the input portion and the output portion of the fluidic path to have a changeable sectional shape for capturing the particle.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: October 7, 2014
    Assignee: Nexvivo Co., Ltd.
    Inventor: Young-Ho Cho
  • Patent number: 8852532
    Abstract: A g-force-sensitive label for detecting and indicating the application of a g-force is provided, the g-force sensitive label comprising an area for detecting and indicating an application of a g-force above a threshold value on the g-force sensitive label and an attachment area for attaching the g-force sensitive label on an object. At least one physical property of the area measurably changes its state upon applying a g-force above the threshold value, thereby altering a displayed pattern such that a machine-readable 1D or 2D or alphanumeric code is displayed.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: October 7, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Frederic Furrer, Mark James Simmons
  • Patent number: 8845967
    Abstract: The present relates to a container and to a device for indirect material cooling and to a method for producing the container according to the invention. Through the present invention a much more efficient indirect heat transfer is facilitated from the exterior of the container into the interior of the container. The improvement of the heat conductivity and of the heat transfer of centrifuge containers yields a reduction of the necessary power of the refrigeration system for cooled centrifuges. Through the higher performance of the centrifuge a higher speed can be run for identical centrifuge temperatures and/or at the same centrifuge temperature and speed, the input power of the refrigeration unit can be reduced.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: September 30, 2014
    Assignee: Eppendorf AG
    Inventors: Bert-Olaf Grimm, Peter Zehnel, Kai Marschner
  • Publication number: 20140256058
    Abstract: The present invention discloses a lid for a sample tube and a sample tube enabling ventilation or sealing depending on the closing position of the lid. Furthermore, a method for drying a sample and a use of the above lid or of the above sample tube for storing or drying a sample are subjects of the present invention.
    Type: Application
    Filed: October 2, 2012
    Publication date: September 11, 2014
    Inventor: Peter Dobrowolski
  • Patent number: 8821361
    Abstract: A centrifugal separator comprising: a driving portion; and a swing rotor including, a rotor body, a through-hole passing through the rotor body, pin insert grooves which are provided parallel to the through-hole so as to oppose each other and only partially penetrate the rotor body, and a bucket including, a bucket body that has a contact surface which is configured to contact the rotor body during centrifugal separation, and a cap assembly that seals the bucket body and has a swing shaft extending in a direction perpendicular to an longitudinal direction of the bucket, wherein the swing rotor is rotated when the bucket is inserted into the through-hole, to swing the bucket, and the swing shaft can be moved in the longitudinal direction of the bucket relative to the bucket body and rotated about a longitudinal central axis of the bucket.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: September 2, 2014
    Assignee: Hitachi Koki Co., Ltd.
    Inventors: Kenichi Nemoto, Hiroshi Hayasaka
  • Publication number: 20140241957
    Abstract: Invention; It is about the tubes used to obtain blood products through centrifuge order to cure open and closed injuries, to heal hard and soft tissues and to diagnose in all fields of medicine and dentistry. Platelet Rich Fibrin (PRF) obtained in the tubes the surface of which contacts blood and made from pure titanium or titanium alloys has a better structure of fibrin than that is obtained through classical methods. The efficiency of the high speed centrifuge is increased with this designed tube and Platelet Rich Fibrin can be removed from the tube without spoiling it.
    Type: Application
    Filed: October 3, 2012
    Publication date: August 28, 2014
    Inventors: Akman Serhan, Tunali Mustafa
  • Patent number: 8808551
    Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: August 19, 2014
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Joel C. Higgins, Matthew Swift, Nathan Gordon
  • Publication number: 20140212336
    Abstract: A rotary analytical device for use with a reagent cartridge. The cartridge may have a housing, an axis, analysis chambers spaced from and located circumferentially about the axis, and a magnetically movable element located in and movable within each analysis chamber to mix fluid in the analysis chamber. The rotary analytical device may have a housing with a cavity having an axis, an impeller extending into the cavity and rotatable about the axis to receive and rotate the cartridge, a motor to rotate the impeller, at least one magnetic element near the cavity and offset from the axis, a light source in the housing to direct a beam of light into the cavity and through the analysis chamber of the cartridge, and a light sensor to receive light from the analysis chamber.
    Type: Application
    Filed: March 28, 2014
    Publication date: July 31, 2014
    Applicant: LAMOTTE CHEMICAL PRODUCTS COMPANY
    Inventors: Horacio Kido, Jim Norton, James W. Egan, JR.
  • Patent number: 8771614
    Abstract: The present invention relates to improved methods for processing fluids and to a fluid processing device (1) for use in a centrifuge comprising: (a) a first holder (14) form-fit to the shape of a first tube (18) for holding said first tube (18) whereby said first tube (18) has a first cross section (A1); and (b) a second holder (22) form-fit to the shape of a second tube (26) for holding said second tube (26) whereby said second tube (26) has a second cross section (A2) that is different from said first cross section (A1). With the fluid processing devices and the methods according to the invention, it is possible to simplify the centrifugal processing steps for a given fluid processing sequence and to automate them.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: July 8, 2014
    Assignee: Qiagen GmbH
    Inventors: Andreas Schaefer, Thomas Voit, Markus Zbinden, Andreas Schmiede
  • Patent number: 8747670
    Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: June 10, 2014
    Assignee: EMD Millipore Corporation
    Inventors: Louis Bonhomme, John Doyle, Kurt Greenizen, George Gagne, Sean Devin, Gerard Lombard, Vincent Smith
  • Patent number: 8747781
    Abstract: A mechanical separator for separating a fluid sample into first and second phases is disclosed. The mechanical separator includes a float, a ballast assembly longitudinally moveable with respect to the float, and a bellows structure. The bellows structure includes a first end, a second end, and a deformable bellows therebetween. The float is attached to a portion of the first end of the bellows structure, and the ballast is attached to a portion of the second end of the bellows structure. The attached float and bellows structure includes a releaseable interference engagement therebetween. The float has a first density, and the ballast has a second density that is greater than the first density of the float.
    Type: Grant
    Filed: July 21, 2009
    Date of Patent: June 10, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Benjamin Bartfeld, Jamieson W. Crawford, Robert G. Ellis, Christopher A. Battles, Kenneth Handeland
  • Patent number: 8727133
    Abstract: Method for the preparation of at least one compound with biological properties from blood, where said method is performed in sealed tubes at a pressure below atmospheric pressure, thereby reducing or preventing the bacterial contamination of the compound through handling. The method comprises the repetition, for as many times as is required, of the following steps: connecting a second container that is vacuum-sealed to an extraction device connected in turn to a first container that contains blood separated into fractions, waiting for a period of time until the required fraction(s) is/are transferred, and removing said second container, with it thus being possible to obtain several second containers with different compounds for different medical applications including biological therapies. The steps may be performed in a closed system, without removing the caps of the containers, or alternatively the first container may be opened prior to the introduction of the extraction device.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: May 20, 2014
    Assignee: Biotechnology Institute, I Mas D, S.L.
    Inventor: Eduardo Anitua Aldecoa
  • Patent number: 8679424
    Abstract: A biotip according to an embodiment of the invention moves a reaction mixture along a longitudinal direction under the force of gravity. The biotip includes a chamber formed of a transparent material and filled with a liquid having a smaller specific gravity than the reaction mixture and immiscible with the reaction mixture, and a seal that seals the chamber. The liquid has a volume resistivity of greater than 0 ?·cm and 5×1013 ?·cm or less.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: March 25, 2014
    Assignee: Seiko Epson Corporation
    Inventor: Hiroshi Koeda
  • Patent number: 8673639
    Abstract: Disclosed is a method for isolating stem cells. The method uses a specially designed apparatus including: a container containing an aspirate; a piston having an outer diameter corresponding to the inner diameter of the container and having at least one through-hole; and a connection tube adapted to feed an enzyme or a washing solution into the container through the through-hole, having a tip connected to the through-hole, and connected to an external tube or another container containing the enzyme or washing solution at the other end thereof. The method includes pulling the piston backward to form a negative pressure in the container containing the aspirate and to allow the enzyme or washing solution to enter the container containing the aspirate through the connection tube and the through-hole of the piston.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: March 18, 2014
    Inventor: Hee Young Lee
  • Publication number: 20140072474
    Abstract: An analytical cartridge and a rotary analytical device with which the cartridge cooperates. The cartridge may have a housing, an axis, analysis chambers spaced from and located circumferentially about the axis, and a magnetically movable element located in and movable within each analysis chamber to mix fluid in the analysis chamber. The rotary analytical device may have a housing with a cavity having an axis, an impeller extending into the cavity and rotatable about the axis to receive and rotate the cartridge, a motor to rotate the impeller, at least one magnetic element near the cavity and offset from the axis, a light source in the housing to direct a beam of hat into the cavity and through the analysis chamber of the cartridge, and a light sensor to receive light from the analysis chamber.
    Type: Application
    Filed: September 12, 2012
    Publication date: March 13, 2014
    Inventors: Horacio Kido, Jim Norton, James W. Egan, JR.
  • Publication number: 20140057345
    Abstract: A method including supplying a polypropylene resin, blending the polypropylene resin with Zinc Stearate, and forming a molded article from the polypropylene resin. Further, an article including a polypropylene resin blended with Zinc Stearate.
    Type: Application
    Filed: August 27, 2012
    Publication date: February 27, 2014
    Applicant: FINA TECHNOLOGY, INC.
    Inventors: Mahesh Patkar, Michael McLeod
  • Publication number: 20140045670
    Abstract: An automated centrifuge apparatus for conducting a cell preparation procedure is provided. A rotor assembly supports centrifuge tubes, which are installable at respective tube positions. The tube positions are indexable to an index location. A sensing module monitors the index location during a set of status checks, which relate to the centrifuge tubes. Logic signals generated by the sensing module are used to automatically determine whether the status checks are satisfied.
    Type: Application
    Filed: August 7, 2012
    Publication date: February 13, 2014
    Applicant: MOLECULAR DEVICES, LLC
    Inventors: Thomas L. Smith, Bryan Wade, Edward Verdonk
  • Publication number: 20140045206
    Abstract: A device for separating materials of different densities is provided. A cup body has an internal cavity configured to hold media. An inner wall defines a central body region having an upper and lower end. The upper end is wider than the lower end. An interior shoulder circumscribes the upper end of the central body region. The interior shoulder defines a neck region above the central body region and a shoulder trap below the neck region. The shoulder trap circumscribes the upper end of the central body region and is wider than the neck region. When the device is spun about a central axis, the media travels upward along the inner wall toward the shoulder trap. Relatively more dense material in the media is collected in the shoulder trap, and relatively less dense material is expelled from the device through an opening above the neck region.
    Type: Application
    Filed: August 7, 2012
    Publication date: February 13, 2014
    Applicant: MOLECULAR DEVICES, LLC
    Inventors: Windsor Owens, Andrew Peterson, Yuri Osipchuk, Edward Verdonk
  • Publication number: 20140038307
    Abstract: A reagent vessel insert for a reagent vessel for a centrifuge and/or a pressure varying device includes an insert housing formed such that the reagent vessel insert is insertable in a reagent vessel for a centrifuge and/or for a pressure varying device. The reagent vessel insert also includes at least one agitating element arranged in at least one interior volume such that a place and/or position of the at least one agitating element is changeable with respect to the insert housing. The reagent vessel insert is configured such that at least one material filled into the at least one interior volume is agitatable and such that, during an adjustment, at least one subunit of the at least one agitating element contacting at least one holding structure, by which the at least one agitating element is held in at least one semi-stable place and/or at least one semi-stable position.
    Type: Application
    Filed: August 1, 2013
    Publication date: February 6, 2014
    Applicant: Robert Bosch GmbH
    Inventors: Martina Daub, Guenter Roth, Ame Kloke, Juergen Steigert, Felix von Stetten, Nils Paust
  • Patent number: 8632736
    Abstract: This disclosure is directed to systems for separating a target analyte from a suspension. A suspension is added to a tube. A float is also added to the tube, and the tube, float, and suspension are centrifuged together, causing the constituent components of the suspension to separate into different layers along the axial length of the tube according to their specific gravities. The float has a specific gravity that positions the float at approximately the same level as a layer containing the target analyte, when the tube, float and sample are centrifuged. Prior to isolation, the material may be located between an outer surface of the float and an inner surface of the tube, or within a central bore that extends longitudinally through the float. The target analyte may then be drawn into a compartment within the float, thereby isolating the target analyte from the other suspension constituents.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: January 21, 2014
    Assignee: Rarecyte, Inc.
    Inventors: Paul Spatafore, Jackie Lynn Stilwell, Arturo Ramirez, Evan Castiglia
  • Publication number: 20140017804
    Abstract: A container for selective transport of samples of biological material or of biological origin comprising a body (2) having at least a compartment (3) suitable for containing at least a fluid or liquid and/or for containing at least a portion (16a) of a collecting device (16) for biological samples, said body (2) comprising at least an access opening (4) to the compartment (3) and at least a containing wall (5) provided with at least a selective passage portion (6) configured such as to prevent exit of a fluid or liquid from the container (1), through the passage portion (6), at least in at least an operating sealed condition characterised at least by a rest state of the container (1) or by a first value of mechanical shaking of the container (1) and/or by a first value of relative centrifugal force to which the container (1) is subjected for a first interval of a predetermined time, and configured such as selectively to enable exit of the fluid or liquid from the container (1), across the passage portion (6),
    Type: Application
    Filed: November 17, 2011
    Publication date: January 16, 2014
    Inventor: Daniele Triva
  • Publication number: 20140010739
    Abstract: The present invention relates to a centrifuge vessel assembly for use in a centrifuge, comprising a centrifuge vessel for holding a sample to be centrifuged, an adapter holding the centrifuge vessel, and a holding means holding the adapter for attaching the centrifuge vessel assembly to a rotor of the centrifuge, said centrifuge vessel having a vessel body and a sealable opening through which the sample to be centrifuged can be filled into said vessel, said vessel body having a cross-sectional area and a vessel height, said vessel height being oriented at right angles to said cross-sectional area, wherein said cross-sectional area is in the form of an oval cross-sectional area.
    Type: Application
    Filed: July 9, 2013
    Publication date: January 9, 2014
    Inventor: Norman Ballhause
  • Publication number: 20130343967
    Abstract: The device enables to put the patients own bone marrow derived stem cells on a lyophilized bone allograft covered by human albumin, after a short separation by centrifugation. The cell concentrator comprises a closed housing (1, 2) for receiving a syringe (7) for holding tissue aspirates and a container (12) below said syringe (7) for receiving the concentrate received by centrifugation; means for clamping the syringe within said housing (1, 2); means for releasable locking the plunger (6) of the syringe (7) and means for pushing the plunger (6) of the syringe (7) along a predetermined length, to introduce at least a part of the concentrate into said container (12). The built-in pushbutton mechanism designed to spray the proper amount of stem cell rich fluid to the surface of the bone graft.
    Type: Application
    Filed: January 6, 2011
    Publication date: December 26, 2013
    Applicant: LACERTA TECHNOLOGIES INC.
    Inventors: Viktor Izápy, Miklós Weszl, Zsombor Lacza
  • Patent number: 8602958
    Abstract: Assemblies for and methods of coupling a microtiter plate and receptacle for centrifugation of liquid from the microtiter plate to the receptacle are provided. In some embodiments, a coupling frame can be used. In other embodiments, the microtiter plate couples directly to the receptacle. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the x-y plane. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the x-z plane. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the y-z plane.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: December 10, 2013
    Assignee: Life Technologies Corporation
    Inventors: Patrick D. Kinney, Michele E. Wisniewski, Jon A. Hoshizaki, David M. Liu, Joon Mo Yang
  • Patent number: 8603415
    Abstract: A microchip including a separation portion for separating a first component and a second component from a sample containing the first component and the second component, respectively, a first collection portion for collecting the first component, a second collection portion for collecting the second component, a first flow path for guiding the first component from the separation portion to the first collection portion, and a second flow path for guiding the second component from the separation portion to the second collection portion is provided.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: December 10, 2013
    Assignee: Rohm Co., Ltd.
    Inventor: Masato Yamaichi