Cartridge, Cassette Or Cuvette Patents (Class 422/554)
  • Patent number: 11266337
    Abstract: Herein, systems and methods are disclosed including a sample acquisition component (SAC) for user-friendly sample collection, a separation component for optional separation of plasma, and one or more stabilization components for stabilizing analytes. In a particular embodiment, the system and methods are directed towards sample collection and stabilization with optional sample separation. Other embodiments can perform any combination of collection, separation, stabilization or detection.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: March 8, 2022
    Inventors: Alicia Jackson, Rowan Chapman, Diana Maichin, Harry Glorikian
  • Patent number: 10865442
    Abstract: A system may include a flow cell to support analytes of interest; a selector valve coupled to the flow cell to select a flow path through the flow cell from a plurality of flow paths; a pump coupled to the flow cell to displace fluids through the selected flow path during an analysis operation; and control circuitry coupled to the selector valve to command the selector valve to select the selected flow path.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: December 15, 2020
    Assignee: ILLUMINA, INC.
    Inventor: Bradley Kent Drews
  • Patent number: 9360413
    Abstract: The invention relates to a positioning means for a flow cell used for optical detection, comprising a base having at least one contact face, the contact face being provided to make contact with the end of the flow cell, wherein the base has at least one reference face, which is to be aligned and/or positioned relative to the flow channel of a flow cell, and wherein the base is designed to receive a connecting piece in such a way that the latter assumes a predefined attitude and alignment relative to the flow channel.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: June 7, 2016
    Inventors: Erik Baigar, Christian Andreas Hilmer, Andreas Unger
  • Patent number: 9061996
    Abstract: The present invention provides a method to prepare an 18F-labelled tricyclic indole compound comprising a solid-phase extraction (SPE) purification step. This method is particularly suitable for carrying out the radiofluorination method on an automated synthesizer. In addition to the radiofluorination method, the present invention provides a cassette designed to carry out the method on an automated synthesizer.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: June 23, 2015
    Assignee: GE Healthcare Limited
    Inventors: Dimitrios Mantzilas, Gry Helene Olaussen, Torild Wickstrom, Eric Horn, Imtiaz Khan
  • Patent number: 9039903
    Abstract: A dispenser system for delivering various combinations of dispersants to a body of water with the various combinations of dispersants supplied to the body of water through the interchanging of dispensing cartridges which are attachable to a main dispensing cartridge where a condition for interchanging of dispensing cartridges may be triggered by an event.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: May 26, 2015
    Assignee: King Technology, Inc.
    Inventors: Joseph A. King, Jeffrey D. Johnson, Lyle Enderson, Paul Freeberg, Donald Dalland
  • Publication number: 20150136604
    Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
    Type: Application
    Filed: September 29, 2014
    Publication date: May 21, 2015
    Inventors: William D. NIELSEN, Richard J. BELCINSKI, Gregory BOGDAN, David EBERHART, Omar EL-SISSI, Stevan B. JOVANOVICH, Michael RECKNOR, Ezra VAN GELDER, David W. WYRICK
  • Publication number: 20150135502
    Abstract: A motorized latch assembly includes an electric motor, an eccentric cam attached via gears to a shaft of the motor and a latch plate configured to lock the reagent cartridge to the coupler. The eccentric cam is rotated when the shaft of the motor rotates. When the eccentric cam is rotated so that the eccentric cam presses down upon the latch plate, the latch plate moves a sufficient distance to permit the reagent cartridge to be disconnected from the coupler.
    Type: Application
    Filed: October 13, 2014
    Publication date: May 21, 2015
    Inventors: William J. Rankin, Robert Keith Johnson
  • Patent number: 9034280
    Abstract: A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: May 19, 2015
    Inventors: Weston Blaine Griffin, Jaydeep Roy, Phillip Alexander Shoemaker, William Patrick Waters
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Publication number: 20150126708
    Abstract: The present invention provides a method of radio fluorination of biological targeting molecules (BTMs) with the radioisotope 18F. Also provided are novel conjugates useful in the 18F-radio fluorination method, and the use of such conjugates and automated synthesizer apparatus including cassettes for carrying out the method.
    Type: Application
    Filed: December 20, 2012
    Publication date: May 7, 2015
    Inventors: Sajinder Kaur Luthra, Robin Fortt, Ramala Osman Awais, Eric Ofori Aboagye, Graham Smith
  • Publication number: 20150111202
    Abstract: An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations.
    Type: Application
    Filed: December 22, 2014
    Publication date: April 23, 2015
    Inventors: Xuan S. Bui, Anthony L. Hartman, Toshiyuki Fujimaki, Shinji Tokudaiji, Yoshitake Okabe, Yoshitada Mizusawa
  • Patent number: 9005542
    Abstract: The storage arrangement has a chamber. Several Dewar flasks are arranged in the chamber and above them a picking device. The picking device has at least one cassette lift, with which storage cassettes can be removed from above from the Dewar flasks. This arrangement is suitable for storing laboratory objects at very low temperatures.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: April 14, 2015
    Assignee: Liconic AG
    Inventor: Cosmas G. Malin
  • Publication number: 20150098873
    Abstract: A test cassette applicable to an optical reading device capable of reading identification codes includes a test sheet with a supporting layer and a reactive reagent layer; a case for retaining the test sheet; and an identification code situated on a surface of the case for recording a test item and a test standard value of the test cassette.
    Type: Application
    Filed: April 7, 2014
    Publication date: April 9, 2015
    Inventor: HUI-CHI KU
  • Patent number: 8999729
    Abstract: A device for conducting an agglutination assay comprising several reaction vessels, each reaction vessel comprising an upper chamber having an opening for accepting reactants and/or a sample; and a lower chamber comprising an end in communication with the upper chamber for receiving fluids from the upper chamber, a closed end opposite to the end, and a matrix for separating agglutinates from non-agglutinates; wherein the device further comprises a rotating support able to rotate around an axis and holding pivotally the reaction vessels in a way to allow the reaction vessels to pivot about an axis essentially perpendicular to the rotation axis of the support when the latter is rotated, such that the fluids remain in the upper chamber when the support is not rotated, and can flow from the upper chamber to the lower chamber and into the matrix when the support is rotated.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: April 7, 2015
    Assignee: Symbion Medical Systems Sarl
    Inventors: Isabelle Delafosse, Fabrice Ummel, Antonio Yanez
  • Publication number: 20150093307
    Abstract: A certification cassette for testing a pumping apparatus including at least one identification reader. The cassette comprises a housing configured for releasable attachment to the pumping apparatus in an aligned position. A space defined within the housing is configured to receive a rotor of the pumping apparatus therein when the housing is in the aligned position. The space is free of fluid carrying conduits disposed for engaging the rotor. An identification member is positioned in the housing. The identification member is operable to induce an expected identification reader response when the identification reader is functioning properly. The cassette is arranged to operatively align the identification member with the identification reader when the housing is in the aligned position.
    Type: Application
    Filed: September 30, 2014
    Publication date: April 2, 2015
    Inventors: Robert Gaines, John Holste, Christopher Knauper, Joel Wiesner
  • Patent number: 8992865
    Abstract: The present invention relates to a sealing device for closing an introduction aperture, the sealing device comprising a fixed support and a shutter mounted movably in translation relative to the support between an extended position and a final retracted position, wherein the sealing device is in a final retracted configuration and wherein the shutter closes introduction aperture. The device includes locking means for preventing any movement of the shutter when it is in the final retracted position. The sealing device further comprises an intermediate retracted configuration, wherein the shutter is at least partly retracted. The sealing device also comprises motion guiding means for guiding the movement of the shutter and designed so that the extension of the shutter is required to move the shutter from the intermediate retracted position to the final retracted position.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: March 31, 2015
    Assignee: Biocartis NV
    Inventors: Rob Bosma, Ronald De Gier
  • Patent number: 8986612
    Abstract: An apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample. The apparatus includes a source for emitting high intensity ultrasound waves and is adapted to receive a cartridge having a chamber containing the liquid sample, wherein the high intensity ultrasound waves are focused on a focus position at or near a nucleation element extending at least partially into the chamber.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: March 24, 2015
    Assignee: Biocartis NV
    Inventors: Arie R. Van Doorn, Michiel De Jong
  • Patent number: 8986611
    Abstract: A sample analysis apparatus configured to automatically press a start button upon installation of a sample tube is provided. The sample analysis apparatus includes: a body of the sample analysis apparatus; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge; a tube accommodating unit included in the door housing and configured to accommodate the sample tube; a start button included in the body of the sample analysis apparatus and configured to start analysis of the sample; and an operating member positioned at a first position which is distant from the start button the sample tube is not installed in the tube accommodating unit, and a second position which is configured to operate the start button when a sample tube is installed and the door housing is closed.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: March 24, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yong Koo Lee, Tae Soo Kim, In Duk Hwang, Seock Woo Jang, Chul Ho Yun
  • Publication number: 20150079694
    Abstract: An interchangeable disposable measuring cassette for insertion into a measuring apparatus for detecting target molecules in a liquid sample by measuring fluorescence emission has a flow measurement cell in which an excitation radiation provided by the measuring apparatus produces an evanescent field in the liquid sample beyond a boundary layer for the liquid sample and the measurement cell. To be better able to ensure that no sample liquid can cross from the measurement cell into the measuring apparatus, the measuring cassette includes a body including an optically transparent material and a base in contact with the underside of the body. The measurement cell is formed by a cutout provided in the body, the base, or both. The areas on which the body and the base are on top of one another around this cutout are connected to one another directly and in fluid-tight fashion by laser welding.
    Type: Application
    Filed: July 19, 2011
    Publication date: March 19, 2015
    Applicant: DiaSys Diagnostic Systems GmbH
    Inventor: Roland SCHENK
  • Patent number: 8980635
    Abstract: A disposable blood analysis cartridge may include a sample collection reservoir, an absorbance measurement channel, and an optical light scattering measurement channel. One or more valves may be disposed between the sample collection reservoir and the absorbance measurement channel and/or the optical light scattering measurement channel. A negative pressure may be applied to the cartridge to pull sample from the sample collection reservoir through the one or more valves and into the absorbance measurement channel and/or the optical light scattering measurement channel. Once the sample is pulled into the absorbance measurement channel and/or the optical light scattering measurement channel, the one or more valves may be closed. With the one or more valves closed, and in some cases, a pusher fluid may be provided to push the fluid sample to other regions of the disposable fluid blood analysis cartridge.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: March 17, 2015
    Assignee: Honeywell International Inc.
    Inventors: Mark Kelley, Ron Bardell, Robert Janisch, Pamela Wong, Eric Peltola
  • Patent number: 8980572
    Abstract: A method for generating and localizing a signal in a solid phase substrate detection system comprises applying a solution of target material to a substrate; binding the target with a specific affinity molecule having an attached label, the label comprising multiple signal precursor molecules; applying a carrier to the substrate, and treating the label to convert the signal precursor molecules to signal generating molecules. The carrier comprises solvent for the label and thickener for localizing the signal. The carrier may include developer that converts signal precursor molecules to signal generating molecules. Developer is not necessary if the signal precursor molecules are converted to signal generating molecules by e.g. temperature change, pH change, sonication, light irradiation, microwave heating. A test device for detecting target in a fluid sample, and a kit of parts for determining the presence of target in a fluid sample are also disclosed.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: March 17, 2015
    Assignee: Supernova Diagnostics, Inc.
    Inventors: Ling Wai Wong, Pui Yee Cangel Chan, Wing Cheung Mak, King Keung Sin, Reinhard Renneberg
  • Patent number: 8967763
    Abstract: A liquid containing chamber that supplies liquid to a liquid ejecting apparatus includes a first liquid container that is capable of containing the liquid and has a vertically long shape in a mounted position when mounted in the liquid ejecting apparatus, a first projection provided in the first liquid container and a first stirring member supported by the first projection, wherein when the first liquid container in the mounted position is divided into an upper container which is located above the first projection and a lower container which is located below the upper container, the lower container contains the liquid and the upper container contains the liquid and a predetermined amount of air.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: March 3, 2015
    Assignee: Seiko Epson Corporation
    Inventor: Hiroyuki Kawate
  • Patent number: 8961908
    Abstract: An incubation system for incubating membranes in western blot experiments featuring a base with an inner cavity adapted to hold membranes and small amounts of solutions and a lid that can pivot between an open and closed position to respectively allow and prevent access to the inner cavity. A gasket is disposed in between the lid and base to provide a water-tight seal between the lid and base. The systems can be stacked atop one another to allow for multiple systems to be placed atop a moving platform such as a rocking platform or an orbital shaker.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: February 24, 2015
    Inventor: Prashant Bommi
  • Publication number: 20150050186
    Abstract: A valve for dispensing a fluid comprising a dry portion and a wet portion is presented. Only the wet portion is contacted by the fluid. The wet portion comprises a fluid dispenser unit having a inlet opening, a capillary nozzle providing a fluid outlet, a cavity, the capillary nozzle having an end within the cavity, and a plunger. The plunger moves within the cavity into an opening position allowing an inflow of the fluid through the inlet opening through the cavity and an outflow of the fluid through the capillary nozzle. The plunger has a sealing surface directed towards the end of the capillary nozzle. The plunger moves into a closing position for sealing the end of the capillary nozzle with the sealing surface. The dry portion comprises a closing component for exercising a magnetic closing force onto the plunger for attracting the plunger into the closing position.
    Type: Application
    Filed: November 3, 2014
    Publication date: February 19, 2015
    Inventors: Stefan Borja Bammesberger, Sabrina Kartmann, Peter Koltay, Klaus Mutschler, Juergen Spinke, Laurent Tanguy
  • Patent number: 8956580
    Abstract: An analysis cartridge comprising a cartridge body, a first cover, a liquid storage box and a sealing film is disclosed. The cartridge body has an accommodation portion and a first side and a second side opposite to the first side. The first cover covers the first side or the second side of the cartridge body and has a first through hole. The liquid storage box is disposed in the accommodation portion and has a liquid through hole. The sealing film seals the liquid through hole of the said liquid storage box and passes through the first through hole of the first cover, wherein the liquid through hole is exposed by removing the sealing film.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: February 17, 2015
    Assignee: Lite-On Technology Corporation
    Inventors: Cheng-Chang Lai, Fu-Chun Huang, Yuh-Jiuan Lin
  • Publication number: 20150045234
    Abstract: A fluidic system that includes a reagent manifold comprising a plurality of channels configured for fluid communication between a reagent cartridge and an inlet of a flow cell; a plurality of reagent sippers extending downward from ports in the manifold, each of the reagent sippers configured to be placed into a reagent reservoir in a reagent cartridge so that liquid reagent can be drawn from the reagent reservoir into the sipper; at least one valve configured to mediate fluid communication between the reservoirs and the inlet of the flow cell. The reagent manifold can also include cache reservoirs for reagent re-use.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 12, 2015
    Applicant: ILLUMINA, INC.
    Inventors: Michael Stone, Drew Verkade
  • Patent number: 8951805
    Abstract: A system for managing bulk liquids for an automated clinical analyzer. The system comprises (a) at least one local reservoir for storing a bulk liquid for impending use, (b) at least one container for holding a bulk liquid before the liquid is transferred to a local reservoir, and (c) a controller for monitoring the level of a bulk liquid in a local reservoir. The local reservoir for storing a bulk liquid for impending use can be a trough. The use of troughs for storing a reagent, a diluent, or some other treating agent for impending use enables an aspirating/dispensing device having a plurality of pipettes to aspirate and dispense the reagent, diluent, or other treating agent at a high rate of throughput. The controller can monitor the level of a liquid in (a) a local reservoir for storing a bulk liquid for imminent use and the level of liquid in a (b) container for holding a bulk liquid before the liquid is transferred to a local reservoir.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: February 10, 2015
    Assignee: Abbott Laboratories
    Inventors: Patrick P. Fritchie, Gregory E. Gardner, Richard W. Mahoney
  • Patent number: 8951474
    Abstract: The present invention provides an apparatus for analyzing particles in a solution including a unit configured to place a flow cell having a flow path for flowing a sample solution containing the particles; a unit configured to illuminate the sample solution flowing through the flow path of the flow cell; a photodetector that detects a scattered light and/or fluorescence generated from the particles in the sample solution; and a unit configured to analyze the particles based on their signal intensities detected by the photodetector, wherein the flow cell has the flow path formed in a substrate, a reflection plane is formed on the side surface of the flow path, the reflection plane leads the lights generated in the flow path of the flow cell and advancing in the substrate in-plane direction to a specified region of the surface of the flow cell, and the photodetector detects the light exiting from the specified region to the outside.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: February 10, 2015
    Assignee: On-Chip Biotechnologies Co., Ltd.
    Inventor: Kazuo Takeda
  • Publication number: 20150037228
    Abstract: A replaceable cartridge for a biological analyte measurement device includes housing configured for removable engagement therefrom, and a support medium disposed within the housing. The support medium carries test pads made of a thin layer of fluid transporting material, and hermetic isolation pads made of a fluid impermeable material. The housing provides a port through which test pads are exposable to an external environment; and a set of sealing elements that define a cross sectional area within a channel internal to the housing, through which the support medium, test pads, and hermetic isolation pads are displaceable. Engagement of a hermetic isolation with the set of sealing elements results in the formation of a hermetic seal within the housing. Hermetic isolation pads can be formed as portions of cleanse pads that can be wiped across surfaces corresponding to a set of sensors, or as sealing pads separate from cleanse pads.
    Type: Application
    Filed: July 31, 2014
    Publication date: February 5, 2015
    Inventors: Roobik AZARNIA, Robert Allen RAY
  • Publication number: 20150031051
    Abstract: Methods, devices, apparatus, and systems are provided for image analysis. Methods of image analysis may include observation, measurement, and analysis of images of biological and other samples; devices, apparatus, and systems provided herein are useful for observation, measurement, and analysis of images of such samples. The methods, devices, apparatus, and systems disclosed herein provide advantages over other methods, devices, apparatus, and systems.
    Type: Application
    Filed: October 7, 2014
    Publication date: January 29, 2015
    Inventors: Karan Mohan, Chinmay Pangarkar, James R. Wasson
  • Publication number: 20150031121
    Abstract: Disclosed is a sample holding carrier allowing samples to be measured accurately, and a fluorescence detection device for use with the sample holding carrier. A biosensor substrate includes a base substrate, a plurality of wells formed on a first surface side of the base substrate; and grooves formed on the first surface side of the base substrate separately from the wells and generating fluorescence under exposure to excitation light. The fluorescence detection device applies excitation light to the grooves, thereby figuring out the level of the fluorescence to be detected from the biosensor substrate. As a result, the fluorescence detection device can amplify the detection signals of the fluorescence generated when the excitation light is applied to the wells to an appropriate level, thereby accurately detecting the fluorescence generated in the samples.
    Type: Application
    Filed: October 14, 2014
    Publication date: January 29, 2015
    Inventors: Morio NAKATANI, Masaya NAKATANI, Yoshiyuki MATSUMURA, Kenji NAGATOMI, Akio OKI
  • Kit
    Patent number: 8940248
    Abstract: A kit comprising a carrier and vessels arranged on the carrier, wherein different reagents are contained in different vessels, the vessels are arranged with an openable closing device on top of the carrier, the carrier has a footprint on the bottom side for being placed on a base, and the carrier has bottom positioning means for being positioned on at least one workplace of an automated laboratory system for microtiter plates according to the SBS standard.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: January 27, 2015
    Assignee: Eppendorf AG
    Inventors: Judith Lucke, Jens-Peter Kroog, Helmut Knofe
  • Patent number: 8940540
    Abstract: A portable, hand-held glucose testing device includes a housing configured to accommodate a plurality of test sensors in a stacked arrangement and having a wall with an opening defined therein. A plurality of packaged test sensors is stacked in alignment with one another within the housing. Each of the test sensors is packaged within a blister package. The blister package includes a blister package housing and a cover foil overlying a surface of the blister package housing and the test sensor. A drive slide is configured to displace one of the plurality of packaged test sensors out of alignment with other packaged test sensors. A knife mechanism is configured to pierce through the cover foil, and to engage and urge the test sensor to extend through the opening for receiving a sample. A meter contact is configured to engage the test sensor when the test sensor extends through the opening.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: January 27, 2015
    Assignee: Bayer HealthCare LLC
    Inventors: Steven C. Charlton, Allen Brenneman
  • Publication number: 20150010992
    Abstract: Systems and methods for determining the presence and/or amount of analytes in a fluid sample are described.
    Type: Application
    Filed: July 21, 2014
    Publication date: January 8, 2015
    Inventors: William Fleming, Robert Buck, Ray Miracle, Dan Morrow, Louis Dietz, Scott Myrick
  • Publication number: 20150004624
    Abstract: A method of determining a presence of target molecules in a body fluid (16) with cells comprises the steps of: lysing cells in the body fluid (16) for generating a lysate (17); mixing the lysate (16) with particles (36) with first detector molecules; binding target molecule to the particles through first detector molecules; exposing a substrate (38) with second detector molecules to the lysate (17); binding target molecules to the substrate through second detector molecules; detecting particles (36) attached to the substrate (36).
    Type: Application
    Filed: January 14, 2013
    Publication date: January 1, 2015
    Inventors: Peggy De Kievit, Bram De Regt, Wendy Uyen Dittmer, Joukje Garrelina Orsel
  • Patent number: 8920754
    Abstract: An exemplary embodiment of the present invention relates to a cuvette of which an inner space thereof is easily cleansed while minimizing its inner space. A cuvette according to an exemplary embodiment of the present invention includes an upper portion having an inlet and forming a first inner space; a middle portion following the first inner space and forming a second inner space that is smaller than the first inner space; and a lower portion following the second inner space and forming a through hole having an interior diameter that is narrower than a cross-section of the second inner space. Accordingly, the through hole functions as a valve to stop the solution when the solution is divided to the inner space for the test, and after the test, the inlet is pressed such that the through hole functions as a nozzle when cleansing such that the solution may be exhausted therefrom.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: December 30, 2014
    Assignee: Postech Academy-Industry Foundation
    Inventors: Joon-Won Kim, Wan-Kyun Chung
  • Patent number: 8920721
    Abstract: A machine for treatment and/or analysis of biological samples is provided. The machine includes a hinged arm to which a clamp for gripping a first biological sample holder is fixed. The clamp includes first and second arms able to move relative to each other along a gripping position between a first position of gripping the first biological sample holder, and a first position of releasing the biological sample holder. Each arm of the clamp includes a groove. When the first and second arms are in the first position of release, the first and second grooves are spaced away from each other along the gripping direction, and when the first and second arms are in the first gripping position, the first and second grooves are brought closer to each other along the gripping direction, so as to be able to receive lateral edges of and grip the first biological sample holder.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: December 30, 2014
    Assignee: Noviloire SA
    Inventors: Michel Philippon, Sébastien Bernay
  • Publication number: 20140377148
    Abstract: A tissue handling device is disclosed. A tissue collecting device is disclosed. A cassette for handling biological tissues is disclosed. A tissue dyeing device is disclosed. A method for handling biological tissues is disclosed. A method for dyeing biological tissues is disclosed.
    Type: Application
    Filed: January 10, 2013
    Publication date: December 25, 2014
    Inventors: Alex Pasternak, Keren Shapira-Schweizer, Shaike Schatzberger
  • Patent number: 8916113
    Abstract: An automatic chemical analyzer in which a reaction solution is stirred by air ejected from an air ejection hole placed above a reaction container. The reaction region can be washed and cleaned sufficiently without causing damage, such as exfoliation of a coating reagent. A reaction container disk 161 is provided with a pore 240 and a pressure detector 241 connected with the pore. Before and after the stirring operation, the ejection hole (nozzle) 170 ejecting air is moved and the output value of the pressure detector is compared with a previously measured normal value. With a discharge pipe 1101 and a suction pipe 1102 inserted to the opening of the reaction container 1140 to be close to both ends of the opening and the side wall of the container, the reaction region 1150 at the bottom of the container is washed by continuous discharge and suction of cleaning fluid.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: December 23, 2014
    Assignees: Hitachi High-Technologies Corporation, Roche Diagnostics Operations, Inc.
    Inventors: Hironobu Yamakawa, Yoichi Aruga, Takenori Okusa, Kenichi Takahashi, Hans Hornauer, Hans-Juergen Mueller
  • Publication number: 20140370583
    Abstract: The invention is directed to multi-fluidic cartridges for sample analysis and to methods of using said cartridges. In one embodiment, the cartridge comprises: (a) a first conduit beginning at a sample entry port for receiving a fluid sample and in fluid communication with one or more sensors; (b) a plurality of rupturable fluidic pouches, each containing a different fluid and in fluid communication with a respective delivery conduit configured for delivering a respective fluid to said first conduit; and (c) at least one pneumatic pump configured to move said fluid sample to said one or more sensors and for transporting at least one of said different fluids to said first conduit.
    Type: Application
    Filed: August 29, 2014
    Publication date: December 18, 2014
    Inventor: Cary James Miller
  • Publication number: 20140364615
    Abstract: An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 11, 2014
  • Patent number: 8906326
    Abstract: A biochemical reaction cassette having a structure for uniformizing a liquid flow in a reaction chamber with a simple additional arrangement is provided. A fluid resistive section is arranged in a channel that is constructed to include an injection port, a reaction chamber, and a discharge port. The fluid resistive section decreases the cross-sectional area of the channel to decrease the fluid resistance at ends in the width direction of the fluid resistive section and at positions remote from the injection port and the discharge port, where the flow rate is decreased.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: December 9, 2014
    Assignee: Canon Kabushiki Kaisha
    Inventors: Takaaki Aoyagi, Tomoyuki Makihira
  • Publication number: 20140356234
    Abstract: Improvements in and relating to devices for receiving liquid samples A device for receiving a liquid sample may form part of a micro sampling head for an instrument such as a spectrophotometer. The device receives a liquid sample to be analysed by a process involving the passing of electromagnetic radiation through the sample, and comprises a light inlet guide (20) for directing electromagnetic radiation into the sample, a light receiving element (23) situated in an opposed relationship to the guide and spaced from the guide by a fixed distance to define a fixed path length gap (21), which is, in use, filled with the sample. In use, radiation is passed from the light inlet guide to the light receiving element (23), and the path length of radiation through the sample is defined by the gap (23). The device is open or openable to allow a droplet of sample to be deposited directly in the gap.
    Type: Application
    Filed: November 8, 2012
    Publication date: December 4, 2014
    Inventor: Graham Eric Gifford
  • Patent number: 8900514
    Abstract: The invention discloses a blood analyzing device (100) comprising a holder (110) arranged for carrying a container (10) having a cuvette (20) containing a blood sample (30). The container (10) is positioned in the holder (110) so that a longitudinal axis (60) of the cuvette (20) is angled relative a horizontal axis (70). A light source (120) provides light (40) into the sample (30) and a detector (130) detects the output light (50) from a sub-portion of the blood sample (30). Kinetic information indicative of the change in hemoglobin concentration in a measuring volume (32, 34) is determined by a Hb processor (145) from the detected output light (50). An ESR processor (140) determines the erythrocyte sedimentation rate of the sample (30) based on the kinetic information.
    Type: Grant
    Filed: September 1, 2008
    Date of Patent: December 2, 2014
    Inventor: Tommy Forsell
  • Patent number: 8894951
    Abstract: A specimen collection container having a transitional fill-volume indicator is disclosed. The specimen collection container includes an open top end, a closed bottom end, and a sidewall extending therebetween defining an interior. The specimen collection container includes a transitional fill-volume indicator adjacent the sidewall, such that the container defines a first volumetric interior defined by the sidewall between the closed bottom end and the transitional indicator. The specimen collection container also defines a second volumetric interior defined by the sidewall between the closed bottom end and a portion of the sidewall disposed above the transitional indicator.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: November 25, 2014
    Assignee: Becton, Dickinson and Company
    Inventors: Bradley M. Wilkinson, Craig Owen Russ
  • Patent number: 8895152
    Abstract: The invention relates to a method for generating at least one electrically contactable area on a polymer which is doped with a conductive substance, wherein a contact material is applied onto the polymer, which has a lower specific resistance at 23° C. than the polymer. According to the invention the contact material is applied onto the polymer so tightly that close contact between the contact material and the conductive substance is achieved. Due to the tight application of the contact material, which has a lower specific resistance than the polymer, the input resistance of the doped polymer is effectively reduced. The invention further concerns a formed body made of a polymer which is doped with a conductive substance, which has at least one contactable area, within which a contact material is applied onto the polymer, which has a lower specific resistance at 23° C. than the polymer.
    Type: Grant
    Filed: October 25, 2004
    Date of Patent: November 25, 2014
    Assignee: Lonza Cologne GmbH
    Inventors: Herbert Mueller-Hartmann, Ewald Fernbach, Gregor Siebenkotten
  • Patent number: 8894950
    Abstract: Disclosed is a test cassette comprising a continuous length of test carrier tape (22) in a supply chamber (12), the supply chamber (12) having an opening (52) sized so as to allow the test carrier tape (22) to pass through into a test zone (32) into an uptake chamber (14) where the test carrier tape (22) coils itself onto an uptake mandrel (26), the supply chamber (12) being sealed from the environment whereby the opening (52) of the supply chamber (12) allowing the exit of the test carrier tape (22) has a spacer (42) disposed either side of it, filling the remaining width of the opening (52) of the housing (16), a cover plate (34) being biased by a spring (38) to cover the spacer (42) and tape (22), thus covering the opening (52) and sealing the cassette (10).
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: November 25, 2014
    Inventor: Brandon Bransgrove
  • Publication number: 20140341789
    Abstract: According to one embodiment, an automatic analysis apparatus comprises a stirrer, a moving unit, a vibrating unit, and a control unit. The stirrer is configured to stir a solution mixture which includes a sample of a specimen and a reagent corresponding to a measurement item of the specimen, and is stored in a reaction cuvette. The moving unit is configured to move the stirrer in a first direction as a depth direction of the reaction cuvette. The vibrating unit is configured to vibrate the stirrer in a second direction different from the first direction. The control unit is configured to control the moving unit and the vibrating unit, such that the stirrer moves in the first direction while vibrating in the second direction.
    Type: Application
    Filed: July 30, 2014
    Publication date: November 20, 2014
    Applicants: Kabushiki Kaisha Toshiba, Toshiba Medical Systems Corporation
    Inventors: Xinmin WANG, Xin Li
  • Patent number: 8883094
    Abstract: Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: November 11, 2014
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Qun Huo, Xiong Liu, Qiu Dai
  • Patent number: 8883095
    Abstract: An analysis cartridge and an analysis system thereof are disclosed. The analysis cartridge comprises a cartridge body, a liquid storage box and a sealing film. The cartridge body has an accommodation portion. The liquid storage box is disposed within the accommodation portion and has a liquid storage tank and a pillar receiving hole. The sealing film covers the pillar receiving hole and seals an opening of the liquid storage tank.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: November 11, 2014
    Assignee: Lite-On Technology Corporation
    Inventors: Cheng-Chang Lai, Fu-Chun Huang, Yuh-Jiuan Lin, Timothy Z. Liu