Cartridge, Cassette Or Cuvette Patents (Class 422/554)
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Patent number: 8486721Abstract: Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample with magnetic sacrificial beads opsonized to leukocytes, binding leukocytes in the sample to the magnetic sacrificial beads, and magnetically retaining the beads out of contact from an immunosensor.Type: GrantFiled: July 27, 2012Date of Patent: July 16, 2013Assignee: Abbott Point of Care Inc.Inventors: John Lewis Emerson Campbell, Graham Davis
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Publication number: 20130171043Abstract: The invention comprises a sample chamber for microscopic examinations, comprising a reservoir for receiving a sample, the reservoir being defined by a bottom plate and a side wall, and a parting plate disposed in the reservoir and being parallel to the bottom plate, the parting plate in the reservoir being disposed at a height which is lower than the minimum height of the side wall, so that it divides the reservoir into an upper and a lower partial reservoirs, the lower partial reservoir and the upper partial reservoir being laterally completely bordered by the side wall, and the upper and the lower partial reservoirs being connected by at least one inlet/outlet.Type: ApplicationFiled: December 5, 2012Publication date: July 4, 2013Applicant: IBIDI GMBHInventor: ibidi GmbH
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Publication number: 20130171044Abstract: A biological fluid sample analysis cartridge is provided that includes a collection port and a body. The body has one or more internal channels in selective fluid communication with the collection port. The collection port includes a collection bowl, and a slide valve assembly operable to be selectively positioned in an open position and a closed position. In the open position, the collection bowl is accessible for sample deposition, and in the closed position the collection bowl is inaccessible for sample deposition.Type: ApplicationFiled: December 31, 2012Publication date: July 4, 2013Applicant: Abbott Point of Care, Inc.Inventor: Abbott Point of Care, Inc.
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Publication number: 20130164778Abstract: A two-step method for loading a fluid sample into a disposable fluid analysis cartridge is described. First, capillary action may be used to initially draw a sample through a sample introduction port and into a sample collection reservoir provided in the fluid analysis cartridge. Once the fluid sample has been drawn into the sample collection reservoir by capillary action, a negative pressure may be applied to the cartridge to pull the sample from the sample collection reservoir and into a sample loading channel.Type: ApplicationFiled: December 27, 2011Publication date: June 27, 2013Applicant: HONEYWELL INTERNATIONAL INC.Inventors: Robert Janisch, Pam Wong, Eric Peltola, Ron Bardell, Mark Kelley
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Publication number: 20130164196Abstract: An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to selective vials, and a waste tube system for purging material from the vials. A purging operation can be selectively performed on one or more of the banks of vials. The plurality of vials are stored in the cartridge and are divided among individual banks wherein each bank of vials has a corresponding drain. There is at least one waste tube system for expelling the reagent solution from vials within a particular bank of vials when the waste tube system is coupled to the corresponding drain. The cartridge holding the plurality of vials rotates relative to the stationary banks of valves and the waste tube system.Type: ApplicationFiled: February 25, 2013Publication date: June 27, 2013Applicant: MCLUEN DESIGN, INC.Inventor: McLuen Design, Inc.
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Publication number: 20130164773Abstract: A disposable blood analysis cartridge for analyzing a blood sample including an optical light scattering measurement channel is described. In use, processed sample may be introduced into a sheath fluid channel at an angle, ?, of approximately 90 degrees, relative to the direction of flow of the sheath fluid. In addition, delivering the sample from the side into the sheath fluid may facilitate better positioning of the core within the hydrodynamic focusing channel for measurement.Type: ApplicationFiled: December 27, 2011Publication date: June 27, 2013Applicant: HONEYWELL INTERNATIONAL, INC.Inventors: Ron Bardell, Tzu-Yu Wang, Mark Washa
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Publication number: 20130164857Abstract: An interchangeable disposable measuring cassette for insertion into a measuring apparatus for detecting target molecules in a liquid sample by measuring fluorescence emission has a flow measurement cell in which an excitation radiation provided by the measuring apparatus produces an evanescent field in the liquid sample beyond a boundary layer for the liquid sample and the measurement cell. To be better able to ensure that no sample liquid can cross from the measurement cell into the measuring apparatus, the measuring cassette includes a body including an optically transparent material and a base in contact with the underside of the body. The measurement cell is formed by a cutout provided in the body, the base, or both. The areas on which the body and the base are on top of one another around this cutout are connected to one another directly and in fluid-tight fashion by laser welding.Type: ApplicationFiled: July 19, 2011Publication date: June 27, 2013Applicant: DIASYS DIAGNOSTIC SYSTEMS GMBHInventor: Roland Schenk
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Patent number: 8465978Abstract: Methods and devices for conducting platelet aggregation analysis. A method for conducting platelet aggregation analysis by a cartridge device, including providing a blood sample in the cartridge device, stirring the blood sample within the cartridge device, measuring the electrical impedance between electrodes to obtain measured electrical impedance values, comparing measured electrical impedance values, discarding and repeating the measurements of the electrical impedance in case a variation of the measurements is outside a predetermined threshold range, or reporting the measured electrical impedance values in case the variation of the measurements is within the predetermined threshold range. Reported measured electrical impedance values indicate platelet aggregation in a blood sample.Type: GrantFiled: February 17, 2011Date of Patent: June 18, 2013Assignee: F. Hoffmann-la Roche AGInventors: Andreas Calatzis, Ben Krüger, Marc Wittwer
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Publication number: 20130143328Abstract: An automated assay fluid dispensing system includes a database that associates assay protocols with assay procedures, the procedures including a first assay procedure specifying dissimilar first and second channel procedures for driving first and second channels of a fluid-dispenser cassette. The system includes a controller with a procedure selector to select or to assist a human to select an assay procedure from the database to be executed in an assay run. The controller also includes a cassette driver to drive the cassette to dispense fluids automatically to multiple sites during the assay run so that fluids in the first and second channels are dispensed in accordance with the dissimilar first and second channel procedures. The system includes a cassette interface to engage the cassette so that the controller can drive it to implement the assay run.Type: ApplicationFiled: January 30, 2013Publication date: June 6, 2013Applicant: Hewlett-Packard Development Company, L.P.Inventor: Hewlett-Packard Development Company, L.P.
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Publication number: 20130142711Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.Type: ApplicationFiled: January 23, 2013Publication date: June 6, 2013Applicant: Beckman Coulter, Inc.Inventor: Beckman Coulter, Inc.
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Patent number: 8449827Abstract: A reaction well, intended for use in an automatic analysis appliance and including an opening at its top end and one or two flaps for partially closing said opening, the flaps being separated by a slot enabling a liquid injection or sampling needle to pass through, and preventing stirrer means contained within the well from escaping.Type: GrantFiled: January 23, 2008Date of Patent: May 28, 2013Assignee: Diagnostica StagoInventor: Jean-François Gelin
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Patent number: 8449844Abstract: A container for storing a biological sample is disclosed. The container includes a first chamber having a sidewall extending between an open end and a closed end, defining a first chamber interior adapted to receive a sample holder therein. The container also includes a second chamber having a sidewall extending between an open end and a closed end, defining a second chamber interior adapted to subsequently receive the sample holder therein. The second chamber interior is in fluid isolation from the first chamber interior. A removable closure encloses at least one of the open end of the first chamber and the open end of the second chamber while the sample holder is disposed within one of the first chamber interior and the second chamber interior. A first fluid may be disposed within the first chamber interior, and a second different fluid may be disposed within the second chamber interior.Type: GrantFiled: October 23, 2008Date of Patent: May 28, 2013Assignee: Becton, Dickinson and CompanyInventors: Bradley M. Wilkinson, C. Mark Newby, Clinton A. Haynes, Robert G. States, III
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Publication number: 20130121898Abstract: A reaction cassette for biochemical assay, a biochemical assay device including a first space configured to accommodate liquid, having a first opening and rounding edges, a direction of the first opening being directed upward. A second space includes a second opening, a direction of the second opening being perpendicular to the direction of the first opening, wherein the first space and the second space are disposed such that when the reaction cassette is rotated allowing the liquid to drain into the second space. A third space is located below the first space and having a third opening, a direction of the third opening being upward such that when the reaction cassette is reversibly rotated allowing the liquid to drain into the third space, wherein an array of bumps is disposed in the third space to create turbulence of the liquid. An inner partition wall, connected with the second opening and the third opening, acts as a liquid flow channel between the second space and the third space.Type: ApplicationFiled: November 4, 2012Publication date: May 16, 2013Applicant: APEX BIOTECHNOLOGY CORP.Inventor: APEX BIOTECHNOLOGY CORP.
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Patent number: 8435463Abstract: An apparatus includes a housing having a support surface to support a cartridge, a socket attached to the housing, and an actuator associated with the socket. The socket surface includes one or more socket positioning members, a plurality of electrical contacts and a plurality of magnets. The socket is configured to move relative to the support surface of the housing, with the one or more socket positioning members located in a fixed relation to the plurality of electrical contacts so that when the socket is spaced proximate to the support surface of the housing, the one or more socket positioning members engage with the one or more cartridge positioning members to align the plurality of electrical contacts of the socket with the plurality of electrical contact pads of the cartridge. The actuator is configured to align each magnet with a respective fluid conduit of the processing device.Type: GrantFiled: June 18, 2012Date of Patent: May 7, 2013Assignee: BioScale, Inc.Inventors: Brett P Masters, Eric France, Peter Wight Falb, Matthew Kavalauskas, David Brancazio
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Patent number: 8435465Abstract: A microfluidic cartridge for isolating biological molecules having a capture chamber containing functionalized solid supports maintained in a fluidized state provides reduced pressure drops and bubble formation during microfluidic extraction. The cartridge may include an electric field lysis chamber and/or a chemical lysis chamber. The electric-field lysis chamber may comprise an electrically insulating structure arranged between two opposing planar electrodes.Type: GrantFiled: November 3, 2008Date of Patent: May 7, 2013Assignee: CFD Research CorporationInventors: Shivshankar Sundaram, Balabhaskar Prabhakarpandian, Kapil Pant, Yi Wang
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Publication number: 20130109030Abstract: The invention relates to a cartridge(10) and its use in an examination apparatus(100). A sample(1) can be introduced into an inlet(11) of the cartridge(10) and conducted through a channel(12) to a reaction chamber(13). In the reaction chamber(13), an examination of the sample takes place, for example by frustrated total internal reflection. An agent(21) is applied to the sample close to the inlet(11), wherein said agent(21) is preferably stored in a reservoir(16) at the inlet(11). In this way the filling time of the reaction chamber(13) is simultaneously used for the incubation of the sample with the agent(21). Moreover, the filling-course of the cartridge and/or the reaction chamber may preferably be determined and taken into account during the execution of the examination and/or the evaluation of the results.Type: ApplicationFiled: July 4, 2011Publication date: May 2, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Wilhelmina Maria Hardeman, Toon Hendrik Evers, Theodorus Petrus Henricus Gerardus Jansen
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Publication number: 20130108524Abstract: There is disclosed a tape cassette having a reeled-up carrier tape that carries at least one type of functional elements, namely test elements and/or puncturing elements, that are arranged at a distance from each other in a tape direction. The distances in the tape direction from a functional element to the next functional element of the same type change periodically in space at a period P. Moreover, there is disclosed a method for manufacture of a tape cassette of this type.Type: ApplicationFiled: December 13, 2012Publication date: May 2, 2013Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventor: Roche Diagnostics Operations, Inc.
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Publication number: 20130098939Abstract: A cartridge for holding and ejecting fluid test strips and a test-strip metering device for use with such a cartridge. The cartridge holds the test strips in a sheet-like configuration. The metering device is able to extract test strips from the cartridge in response to an actuation of a single user-interface element. The metering device may test the fluids as each is extracted.Type: ApplicationFiled: October 18, 2012Publication date: April 25, 2013Applicant: Jabil Circuit, Inc.Inventor: Jabil Circuit, Inc.
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Publication number: 20130102018Abstract: The present invention can be described as an apparatus and cartridge for detecting the presence of an analyte in a fluid. The invention can also be described as a method of detecting the presence of an analyte in a fluid using the apparatus and cartridge. The method comprises the steps of clamping a sensor cartridge into a cartridge receiver of the apparatus, providing fluid to a fluid flow-path of the cartridge, illuminating at least a portion of a sensor, and using a photodetector to detect a change in the optical property of the sensor, wherein the change is caused by the presence or absence of an analyte in the fluid.Type: ApplicationFiled: October 18, 2012Publication date: April 25, 2013Applicant: The Research Foundation of State University of New YorkInventor: The Research Foundation of State University of Ne
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Publication number: 20130095010Abstract: A cartridge capable of storing a chemical solution includes a first container, a second container installed within the first container and configured to store the chemical solution, and an exhaust path configured to exhaust a gas generated by the chemical solution stored in the second container, wherein the exhaust path is disposed between the first container and the second container.Type: ApplicationFiled: October 4, 2012Publication date: April 18, 2013Applicants: CANON MARKETING JAPAN KABUSHIKI KAISHA, KABUSHIKI KAISHA ELQUEST, ELK CORPORATIONInventors: CANON MARKETING JAPAN KABUSHIKI KAISH, ELK CORPORATION, KABUSHIKI KAISHA ELQUEST
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Publication number: 20130089476Abstract: A method for detecting and counting particles suspended in fluids, such as bacteria suspended in urine, utilizing dynamic features of the suspended particles and employing light scattering measurements. The disclosed method is suitable for determining the susceptibility of bacteria to antibiotics. A cuvette for detecting bacteria in fluids, which is especially suited for the light scattering measurements, is provided.Type: ApplicationFiled: November 29, 2012Publication date: April 11, 2013Applicant: BacterioScan Inc.Inventor: BacterioScan Inc.
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Publication number: 20130084631Abstract: The invention provides a reagent reservoir system and disposable reaction cassettes using the same. In one aspect, such system comprises a chamber in which dried reagent, particularly lyophilized reagent, is constrained to remain in a defined region of the chamber by a retaining member that obstructs passage of such reagents to other regions of the chamber where they may escape hydration or activation.Type: ApplicationFiled: April 27, 2012Publication date: April 4, 2013Applicant: CepheidInventors: Reuel Van Atta, Dias Lourenco Francisco
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Publication number: 20130078643Abstract: A device for detecting the concentration of biological materials, is formed in a body having a plurality of fluidic paths connectable to a multi-microbalance structure carrying a plurality of microbalances, each microbalance having a sensitive portion facing a reaction chamber. The body and the multi-microbalance structure are configured to be mechanically coupled together and each microbalance is configured to be coupled to a respective fluidic path. Each fluidic path includes an inlet, a duct and a liquid waste, each duct being configured to be coupled with a respective reaction chamber. The plurality of fluidic paths and microbalances form at least one first and one second reference cells and one first sample cell.Type: ApplicationFiled: September 15, 2012Publication date: March 28, 2013Applicant: STMICROELECTRONICS S.R.L.Inventors: Ubaldo Mastromatteo, Gabriele Barlocchi, Flavio Francesco Villa
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Patent number: 8404489Abstract: A nucleic acid extraction kit, which enables the nucleic acid extraction operation to be accomplished safely without causing contamination, and in which the complex preparation of reagents and the disposal treatments that are performed before and after the nucleic acid extraction operation can be performed rapidly and simply, with the extraction performed in an automated manner. The nucleic acid extraction kit includes: a container including reagent wells that each store at least a reagent, a sample well into which a biological sample is introduced, a waste liquid well, and a collection well in which an extracted nucleic acid is collected, and an extraction filter cartridge equipped with an extraction filter for separating and extracting a nucleic acid from the biological sample, wherein the extraction filter cartridge is formed in a manner that enables the extraction filter cartridge to be supported on the waste liquid well and the collection well.Type: GrantFiled: May 20, 2010Date of Patent: March 26, 2013Assignee: Toppan Printing Co., Ltd.Inventors: Shuichi Akashi, Ryoichi Asai
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Publication number: 20130071944Abstract: An article of manufacture embodiment comprises a sample cartridge including a sample substrate, and an enclosure including a sample ingress port. The enclosure mates with the sample cartridge to define a sample container containing the sample substrate which is accessible in the sample container via the sample ingress port. The sample cartridge including the sample substrate is removable from the sample container. A sampling method embodiment comprises disposing a sample on a sample substrate in a sample container and removing a sample cartridge including the sample substrate from the sample container. An article of manufacture embodiment comprises a sample substrate, a sample container containing the sample substrate and including a sample ingress port providing access to the sample substrate in the sample container, and a sample cartridge including the sample substrate. The sample cartridge including the sample substrate is removable as a unit from the sample container.Type: ApplicationFiled: October 4, 2010Publication date: March 21, 2013Applicant: BATTELLE MEMORIAL INSTITUTEInventors: M. Scott Ulrich, R. Reade Harpham, April L. Fiorelli
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Publication number: 20130071858Abstract: An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations.Type: ApplicationFiled: September 21, 2011Publication date: March 21, 2013Applicant: SAKURA FINETEK U.S.A., INC.Inventors: XUAN S. BUI, ANTHONY L. HARTMAN, TOSHIYUKI FUJIMAKI, SHINJI TOKUDAIJI, YOSHITAKE OKABE, YOSHITADA MIZUSAWA
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Publication number: 20130064739Abstract: The invention relates to a piercable hermetic cover (2) for a bioassay cartridge (4) with at least one reaction chamber (6). Characteristic for the invention is that: the cover (2) comprises at least a top layer (8), a middle layer (10), a bottom layer (12), and sites intended for piercing (14); and the cover (2) has, at the sites (16) intended for piercing, a hollow space (18) between the top layer (14) and the bottom layer (12). The present invention also relates to a system (20) comprising a bioassay cartridge (4) and a cover (2) for the cartridge (4). The present invention further relates to use of the cover (2) for covering the cartridge (4).Type: ApplicationFiled: May 24, 2011Publication date: March 14, 2013Inventors: Janne Koskinen, Risto-Matti Ruonamo, Aleksi Soini
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Patent number: 8394325Abstract: Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample with magnetic sacrificial beads opsonized to leukocytes, binding leukocytes in the sample to the magnetic sacrificial beads, and magnetically retaining the beads out of contact from an immunosensor.Type: GrantFiled: June 14, 2010Date of Patent: March 12, 2013Assignee: Abbott Point of Care Inc.Inventors: John Lewis Emerson Campbell, Graham Davis
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Patent number: 8394344Abstract: An indicator for enabling an analytical instrument to positively detect the presence of a vial in respective vial-receiving rack position regardless of whether the vial is oriented in a manner necessary for a code reader to read a code printed on the vial. Translation of a leaf spring upon insertion of a vial into a rack position causes a flag to obscure a code provided adjacent the rack position. An instrument into which the rack is installed interprets the failure of the code reader to detect this code as positive indication that a vial is disposed within the respective rack position.Type: GrantFiled: December 22, 2010Date of Patent: March 12, 2013Assignee: Stratec Biomedical Systems AGInventors: Alexander Schutt, Martin Trump
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Patent number: 8383068Abstract: A cassette for performing multiplex PCR is described. The cassette allows for the automated amplification and detection of multiple nucleic acid targets while limiting contamination. The device facilitates a two-amplification, two-primer PCR protocol which results in highly specific, highly sensitive and semi-quantitative amplification of multiple nucleic acid targets. The cassette contains a cavity, a base with a plurality of chambers, a movable pipette for the transfer of reagents and a detection area. The cassettes are single use, disposable devices which may be loaded with reagents needed for the detection of multiple targets. The cassettes may be used in a hospital or clinical setting to quickly screen clinical samples and detect the presence of infectious agents.Type: GrantFiled: May 14, 2010Date of Patent: February 26, 2013Assignee: iCubate, Inc.Inventors: Jeff Bertrand, Jian Han
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Patent number: 8383041Abstract: Body fluid testing device for analyzing a body fluid comprises a test media tape adapted to collect the body fluid. The test media tape comprises a tape and test media portions. A free tape portion without test medium is located between successive test media portions. The testing device further comprises a supply portion. The supply portion comprises a housing in which uncontaminated test media tape is contained. The housing further has an opening for withdrawing test media tape from the housing. The testing device further has a sealing means for closing the opening against the surrounding. A free tape portion of the test media tape is located between a wall of the housing and the sealing means when the sealing means closes the opening. Further aspects concern a test media cassette with sealing means and a method for providing test media while holding them sealed against humidity during onboard storage.Type: GrantFiled: September 7, 2011Date of Patent: February 26, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Werner Ruhl, Hugo Schrem, Volker Zimmer
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Patent number: 8383067Abstract: A histologic tissue sample support device includes a tissue support formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. A resilient cellular material is coupled to the tissue support and is configured to engage and retain tissue in place during processing and embedding. The resilient cellular material is also capable of successful sectioning in the microtome and porous to allow infiltration of the solvents and chemicals used to fix, process and stain tissue, and of embedding material used to embed the tissue while the tissue is retained by the resilient cellular material.Type: GrantFiled: December 11, 2007Date of Patent: February 26, 2013Assignee: Biopath Automation, L.L.C.Inventor: Warren P. Williamson, IV
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Publication number: 20130045529Abstract: The present invention provides a low cost imaged-based system for detecting, measuring and/or counting labeled features of biological samples, particularly blood specimens. In one aspect, the invention includes a system for imaging multiple features of a specimen that includes one or more light sources capable of successively generating illumination beams each having a distinct wavelength band and a plurality of differentially excitable labels capable of labeling a specimen comprising multiple features, such that each different feature is labeled with a different differentially excitable label.Type: ApplicationFiled: August 20, 2012Publication date: February 21, 2013Inventors: Edward Michael Goldberg, Jeffrey Brooker
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Patent number: 8377398Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.Type: GrantFiled: May 31, 2006Date of Patent: February 19, 2013Assignees: The Board of Regents of The University of Texas System, LabNow, Inc.Inventors: John T. McDevitt, Nicolaos J. Christodoulides, Pierre N. Floriano, Gary N. Douglas, Patrick E. Rogers
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Publication number: 20130040378Abstract: The present invention is directed immunoassay cuvettes that comprise diffusely bound and non-diffusely bound reagents for carrying out an immunoassay. The reaction and detection are carried out in the immunoassay cuvette. The immunoassay cuvette comprises a transparent front wall, a back wall, side walls, a bottom, and a top opening. The back wall of the cuvette has a substantially planar surface made of a non-porous material and comprises a capture zone having reagents non-diffusedly bound and a signal reagent zone having reagents diffusedly bound.Type: ApplicationFiled: October 17, 2012Publication date: February 14, 2013Applicant: ACCESS MEDICAL SYSTEMS, LTD.Inventor: Access Medical Systems, LTD.
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Patent number: 8372343Abstract: Embodiments of the present invention relate to multiple coagulation test cartridges and methods of using such cartridges. In one embodiment the cartridge is a disposable single-use cartridge for use in evaluating blood clotting. The cartridge includes multiple containers, such as tubes, each of which includes one or more coagulation affecting substances. The containers can be pre-filled with substances in amounts suitable for use with a single patient's blood sample. The cartridge may include one or more containers, each of which has multiple sections, or volumes, each section storing a different coagulation affecting substance. In another embodiment the cartridge is used in a method for determining at least one appropriate coagulation affecting substance for modifying a patient's coagulation status using a multiple coagulation test system.Type: GrantFiled: December 7, 2007Date of Patent: February 12, 2013Inventor: Sheldon Goldstein
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Patent number: 8367023Abstract: Provided is a reagent vessel which is inserted into a measuring cassette for measuring a biological sample. The reagent vessel includes: a reagent storage unit including at least one space in which a reagent that is to react with the biological sample is stored; and an adhesive cover sealing up the at least one space in which the reagent is stored, and being stripped off to discharge the reagent from the at least one space when the reagent vessel is inserted into the measuring cassette. Therefore, since a plurality of reagents are poured simultaneously and automatically into a measuring cassette through a reagent vessel, it is possible to simplify manipulations and minimize a measuring time. Furthermore, it is possible to resolve problems regarding storage and distribution of reagents.Type: GrantFiled: June 24, 2008Date of Patent: February 5, 2013Assignee: Infopia Co., Ltd.Inventors: Byeong-woo Bae, Sung-dong Lee, Min-sun Kim, Jae-hyun Yoo, Hyoung-soo Kim, Heon-seok Park, Ju-pyo Hong
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Patent number: 8361418Abstract: In a preferred embodiment of the invention, a closure for a container comprises at least two closure members. The relative position of the closure members with respect to each other is altered upon mating of the closure and container. The alteration of the relative position of the closure members may result in one or more of the members approaching the container more closely. The alteration may result in one or more of the members pressing against the container. The pressing may take place in such a way that exit paths for vapor from fluid in the container would require passage through the pressed surfaces.Type: GrantFiled: May 11, 2011Date of Patent: January 29, 2013Assignee: Labcyte Inc.Inventor: Richard N. Ellson
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Patent number: 8354080Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.Type: GrantFiled: April 12, 2010Date of Patent: January 15, 2013Assignee: Canon U.S. Life Sciences, Inc.Inventors: Ray Tsao, Hiroshi Inoue, Shulin Zeng, Brian Murphy, Kenton C. Hasson
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Publication number: 20130011856Abstract: An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge. The present invention relates to a cartridge for use in measuring a component to be measured contained in a sample, comprising: at least a heat-treatment well for performing heat treatment of the sample; and a reaction well for reacting the component to be measured in the sample with a material specifically reacting therewith.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Applicant: MITSUBISHI KAGAKU IATRON, INC.Inventors: Atsushi YANAGIDA, Takashi KURIHARA, Hiroyuki YOKOI, Atsushi KOYATA, Yoshikazu OKAMURA, Daishi MIYAMOTO
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Patent number: 8329474Abstract: A container for use in processing a biopsy sample. Biopsy sample and materials are received within a sample processing area of the container. A semi-permeable barrier is positioned at a downstream portion of the sample processing area and prevents the prevent passage of the biopsy sample. A cap is positioned at the downstream side of the barrier, and holds fluids within the container.Type: GrantFiled: March 15, 2011Date of Patent: December 11, 2012Assignee: University of MassachusettsInventor: Andrew H. Fischer
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Patent number: 8313713Abstract: A device and method solves the problems of improving precision, in particular in reducing movement of a cuvette, particularly lateral or side to side movement of a cuvette, during the measurement process. The device, which stabilizes a cuvette during a measurement read in an analyzer having a cuvette path of travel, includes: a fixed support located on a first side of the path of travel and abutting a side of the cuvette at a location that does not interfere with an optical window on the cuvette on which the measurement read takes place; and a movable support located on a second side of the path of travel and biased against a side of the cuvette at a location that does not interfere with the optical window on the cuvette on which the measurement read takes place, and which is opposite the side abutting the fixed support.Type: GrantFiled: June 17, 2004Date of Patent: November 20, 2012Assignee: Ortho-Clinical Diagnostics, Inc.Inventors: Merrit N. Jacobs, Robert Anthony Burkovich, David Lee Johnson
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Publication number: 20120282616Abstract: A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.Type: ApplicationFiled: November 4, 2011Publication date: November 8, 2012Applicant: BIOCARTIS SAInventors: Harmina Zeijlstra, Ronald De Gier, Marloes M. E. B. Van De Wal, Ronaldus M. H. Steyvers, Astrid E. Visser
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Patent number: 8303902Abstract: Provided is a slide processing apparatus for processing a plurality of slides to which a bio probe is attached. The slide processing apparatus includes a reaction chamber of which side walls are sealed, and a plurality of reaction heating plates disposed in parallel in the reaction chamber at a first distance from each other. The slides are mounted adjacent to the reaction heating plates in the reaction chamber and in parallel to the reaction heating plates.Type: GrantFiled: August 25, 2009Date of Patent: November 6, 2012Assignee: Samsung Electronics Co., Ltd.Inventor: Byung-Chul Kim
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Publication number: 20120275973Abstract: The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group.Type: ApplicationFiled: July 12, 2012Publication date: November 1, 2012Applicants: HAMMERSMITH IMANET LIMITED, GE HEALTHCARE AS, GE HEALTHCARE LIMITEDInventors: SAJINDER KAUR LUTHRA, FRANK BRADY, NICHOLAS TOBY JEFFERY, ERIK ARSTAD, ALEXANDER MARK GIBSON, DUNCAN WYNN, ALAN CUTHBERTSON, MAGNE SOLBAKKEN
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Publication number: 20120276582Abstract: A disposable cassette for blood analysis includes a housing having an upper panel and a sampling section having a filling inlet; at least one pair of chambers in a form of depression of the upper panel of the housing and sealed by a diaphragm; portions of the diaphragm over the chambers being flexible; and one or more channels adapted to interconnect the pair of chambers; one of the chambers containing a predetermined amount of a reagent for blood analysis; and a sample outlet disposed next to and connected to the chamber containing the reagent, the sample outlet including an outlet cavity recessed from the upper panel, a divider disposed therein, and a cover covering the outlet cavity; the sample outlet sealing the reagent to the chamber containing the reagent. Further disclosed is the method of using the disposable cassette for measurements of hematology parameters on a blood analyzer.Type: ApplicationFiled: July 9, 2012Publication date: November 1, 2012Inventors: Kalle RITZEN, Ingemar BERNDTSSON, Bjorn ROOS, Gunnar MAGNUSSON
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Patent number: 8298497Abstract: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber (2); and a plunger element (4) arranged and operable for insertion into the mouth of a selected storage chamber so as to displace a selected reagent from therewithin into the reaction or test chamber (2) generally therebelow by gravitational liquid overflow from the mouth of the chamber. The apparatus may conveniently be provided as a discrete delivery unit, with the storage chambers (5,6) prefilled with the selected reagents.Type: GrantFiled: December 14, 2009Date of Patent: October 30, 2012Assignee: The Secretary of State for DefenceInventor: David James Squirrell
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Publication number: 20120252109Abstract: The invention relates to a reagent cartridge 10 for an assembly for selectively performing a clinical chemical test or an ELISA assay comprising a housing 11 having at least one cavity 12, 13, 14 that contains a reaction or diluting component and having a recess 15 in which a solid phase 20 to which an antigen or antibody can be coupled is inserted into the recess 15 of the housing 11. It is particularly advantageous if the reagent cartridge 10 comprises three cavities 12, 13, 14 and the reagent cartridge 10 can be used for analyzing clinical chemical parameters, for analyzing immunodiagnostic parameters, for providing additional reagents, and as a diluting cartridge.Type: ApplicationFiled: September 17, 2010Publication date: October 4, 2012Applicant: DRG Instruments GmbHInventors: Alfred Janetzko, Wilhelm Sänger, Cyril E. Geacintov
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Patent number: 8277764Abstract: A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.Type: GrantFiled: December 5, 2005Date of Patent: October 2, 2012Assignee: Cytonome/ST, LLCInventors: John R. Gilbert, Hugh Lewis, Derek Beaupre, Jaishree Trikha, Manish Deshpande
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Publication number: 20120244074Abstract: The present invention provides alternative in vivo imaging agents suitable for use in the detection of ?v?6 expressed in a subject. The invention also provides a method for obtaining said in vivo imaging agents, and use of the in vivo imaging agents in determining ?v?6 expressed in a subject.Type: ApplicationFiled: December 16, 2010Publication date: September 27, 2012Inventor: Magne Solbakken