Means Is Conveyor And Rack Patents (Class 422/65)
  • Patent number: 9322835
    Abstract: A biologic fluid sample analysis method and system is provided that includes a reagent depository, and analysis chamber, a biologic fluid transfer system, and a programmable analyzer. The reagent depository has a plurality of reagent deposits, and each reagent deposit located at a position within the depository independent of the other reagent deposits. The analysis chamber is adapted to quiescently hold a biologic fluid sample and one or more reagents during analysis. The biologic fluid transfer system has at least one fluid transfer device. The programmable analyzer is adapted to control the biologic fluid transfer system to acquire a volume of sample from a sample reservoir, dispense a volume of the sample into the reagent depository, acquire a volume of sample and reagent from the reagent depository, and to transfer the sample and reagent to the analysis chamber, and to analyze the combined sample and reagent.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: April 26, 2016
    Assignee: Abbott Point of Care, Inc.
    Inventor: Stephen C. Wardlaw
  • Patent number: 9304069
    Abstract: The invention relates to an apparatus for treatment of histological samples. The apparatus includes at least a working station, in which the sample gets into contact with a liquid reagent. Further, the apparatus includes a purification device, which blows off at least a part of the reagent adhering to the sample and/or the sample holding arrangement by means of a gas flow, or which sucks off at least a part of the reagent adhering to the sample and/or a sample holding arrangement.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: April 5, 2016
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Andrew Guy, Stella Knorr, Hermann Ulbrich
  • Patent number: 9297797
    Abstract: A method of determining an electrolyte in a sample including adding the sample to an electrolyte module, the electrolyte module including a dilution cup, a flow cell, and a pump, the flow cell having a flow channel with a first end and a second end, the first end fluidically coupled to the dilution cup, and the second end fluidically coupled to the pump; combining the sample with a diluent in the dilution cup to produce a diluted sample; operating the pump to aspirate the diluted sample into the flow cell; measuring the electrolyte in the diluted sample in the flow cell; and reversing the pump to dispense fluid through the second end to displace the diluted sample from the flow cell back into the dilution cup.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: March 29, 2016
    Assignee: Beckman Coulter, Inc.
    Inventors: Richard Lou Situ, Youqin E. Xie, Yuan M. Xie
  • Patent number: 9297822
    Abstract: A laboratory system for handling sample tube racks, an alignment element for sample tube racks and a rack tray receiver assembly are disclosed. The laboratory system to handle laboratory sample tube racks includes a robotic arm (220) with a gripper (222) for gripping primary racks (PR), the primary racks (PR) to be handled include a first end surface (76) and a second end surface (78), the first end surface (76) having a first surface geometry and the second end surface (78) having a second surface geometry, and the gripper (222) includes a first gripping arm (226) and a second gripping arm (228), with the first gripping arm (226) having a gripping surface being complementary to the first surface geometry, and the second gripping arm (228) having a gripping surface being complementary to the second surface geometry.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: March 29, 2016
    Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Rolf Frey, Fritz Goedl, Bruno Koch, Joachim Lackner, Ueli Stettler, Beat Widmer
  • Patent number: 9291633
    Abstract: After being dispensed, a sample that needs to be quickly measured passes through another unit and is transported to an automatic analyzer. A plurality of units are provided for functions of processing including a dispensing unit that dispenses the sample stored in a sample vessel into another sample vessel. At least one discharge line discharges the sample from the dispensing unit to a transport line and a line that is perpendicular to the discharge line. A reverse direction transport line transports the sample in a direction reverse to a direction in which the sample loaded in the system is transported to the dispensing unit. The sample that is processed by the dispensing unit is transported to a storage unit located on the upstream side of the system, through the reverse direction transport line.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: March 22, 2016
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Hiroshi Ohga, Tatsuya Fukugaki, Tetsuya Isobe, Shigeru Yano
  • Patent number: 9283557
    Abstract: A laboratory liquid handling system includes a pipetting module, a lab member, and a drive system. The pipetting module includes a pipettor including a pipettor shaft and a pipetting tip extending from an end of the pipettor shaft. The lab member includes a body and at least one adapter structure including an interlock feature configured to laterally receive and interlock with the pipettor shaft to releasably secure the lab member to the pipettor shaft. The drive system is operable to: selectively move the pipettor shaft laterally relative to the interlock structure to engage the pipettor shaft with the interlock structure to secure the lab member to the pipetting module; move the pipetting module to transport the lab member secured thereto; and selectively move the pipettor shaft laterally relative to the interlock structure to disengage the pipettor shaft from the interlock structure to thereby release the lab member.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: March 15, 2016
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Eugene S. Maslana, Karen A. McElroy, Dennis F. Malkowski, James W. Sim
  • Patent number: 9279819
    Abstract: A sample processing system is disclosed which includes at least one processor and at least one memory that stores programs executable collectively by the at least one processor. According to the stored programs, the at least one processor transports sample containers through a conveying path along which there are arranged at least one first module for testing of samples and at least one second module for processing of samples which have been tested by the at least one first module. The at least one second module is switchable between an active state and an inactive state. The at least one processor further obtains a determination result as to whether a sample which has been tested by the at least one first module is necessary to be processed by the at least one second module.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: March 8, 2016
    Assignee: SYSMEX CORPORATION
    Inventors: Toru Mizumoto, Akio Toyoda
  • Patent number: 9269138
    Abstract: Methods for dispensing a fluid sample on a substrate include obtaining an image of a sample applicator in proximity to the substrate, where the image includes a first image of the sample applicator and a second image of the sample applicator, determining a height of the sample applicator relative to a surface plane of the substrate based on a distance between common portions of the first and second images, and dispensing the fluid sample onto the substrate using the sample applicator, where the dispensing includes: translating the sample applicator, translating the substrate, or translating both the sample applicator and the substrate to effect a relative translation between the sample applicator and the substrate; and maintaining the sample applicator within 2 microns of a target height relative to the surface plane of the substrate during the translating.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: February 23, 2016
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: Russell Zahniser, David Zahniser, Stephen Conroy, Michael Zahniser
  • Patent number: 9259673
    Abstract: An assembly machine for assembling disposable syringe-driven filter is provided, which includes a rack and an automatic controller arranged on the rack. The automatic controller is electrically connected with a rotating table, a first automatic loading mechanism, an automatic filter disc-sucking mechanism, a second automatic loading mechanism, and an automatic unloading mechanism. Using the first and second automatic loading mechanisms, the automatic filter disc-sucking mechanism, and the automatic unloading mechanism, as well as the automatic controller, the assembly machine can realize the automatic loading of the upper cover of a disposable syringe-driven filter, the automatic placing of filter disc, the automatic loading and assembling of the lower cover of filter and the automatic unloading of the disposable syringe-driven filter, so that the automatic production of the disposable syringe-driven filter can be realized.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: February 16, 2016
    Inventors: Jianhua Yuan, Yejames Yuan
  • Patent number: 9244088
    Abstract: Stepped portions of a flow channel are reduced by completely fixing the channel that extends to the measuring unit, and reducing connections in the channel, thereby to suppress a disturbance in the flow of the liquid suctioned into the measuring unit. A means is provided so that the reaction solution and reagent suctioned will move towards the channel through which the liquids are suctioned.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: January 26, 2016
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Susumu Sakairi, Taku Sakazume, Katsuaki Takahashi
  • Patent number: 9229071
    Abstract: The invention relates to the identification of molecules using electromagnetic write-heads and magneto-resistive sensors. In one embodiment, an electromagnetic write-head magnetically excites a molecule with an alternating magnetic field. A magneto-resistive sensor measures the resonant response of the magnetically excited molecule. A processor compares the resonant response to a table of known responses of different molecules to identify the chemical composition of the target molecule.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: January 5, 2016
    Assignee: International Business Machines Corporation
    Inventors: Allen Keith Bates, Anna Wanda Topol, Daniel James Winarski
  • Patent number: 9229019
    Abstract: A sample-processing system that improves total system processing efficiency, and reduces a sample-processing time, by establishing a functionally independent relationship between a rack conveyance block with rack supply, conveyance, and recovery functions, and a processing block with sample preprocessing, analysis, and other functions. A buffer unit with random accessibility to multiple racks standing by for processing is combined with each of multiple processing units to form a pair, and the system is constructed to load and unload racks into and from the buffer unit through the rack conveyance block so that one unprocessed rack is loaded into the buffer unit and then upon completion of process steps up to automatic retesting, unloaded from the buffer unit. Functional dependence between any processing unit and a conveyance unit is thus eliminated.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: January 5, 2016
    Assignee: HITACH HIGH-TECHNOLOGIES CORPORATION
    Inventors: Hitoshi Tokieda, Yoshimitsu Takagi, Takeshi Shibuya, Masashi Akutsu
  • Patent number: 9222952
    Abstract: A sample processing system comprising: first, second and third sample processing units; first, second and third sample transport units; and a control section is disclosed. In order to transport a sample rack which is to be introduced to the first sample transport unit to a destination sample transport unit which is located downstream of a second sample transport unit, the control section initially controls the first and second transport unit to move a transport member. When the sample rack arrives at a predetermined position on the transport path of the first transport unit, the control section controls the third transport unit to move a transport member.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: December 29, 2015
    Assignee: SYSMEX CORPORATION
    Inventors: Hiroo Tatsutani, Hiroyuki Tanaka
  • Patent number: 9194878
    Abstract: An automatic analysis device has a light scattering photometer incorporated therein, and improved accuracy resulting from reducing the influences from external light. The automatic analysis device includes a scattered light measurement unit disposed inside the main-body casing, and openable/closable protective covers to cover the top face of the main-body casing. A first protective cover at the center includes a light-shielding part to block external light. The protective covers include see-through parts enabling viewing of the inside. The light-shielding part is configured to cover an area of the reaction disk at least corresponding to the area above the scattered light measurement unit, thus reducing external light leaking into the scattered light measurement unit, and thus removing influences from external light on the scattered light measurement. The protective cover may have a divided structure.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: November 24, 2015
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Mitsuru Oonuma, Yoko Sato, Hajime Yamazaki, Akihito Wakui
  • Patent number: 9186677
    Abstract: The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: November 17, 2015
    Assignee: HANDYLAB, INC.
    Inventors: Jeff Williams, Kerry Wilson, Kalyan Handique
  • Patent number: 9174779
    Abstract: An elastomeric vial cap used for sealing a vial container, but allowing pipette access to its containment fluid includes an annular flange portion for capping the vial and a sloped truncated cone portion to easily guide the pipette into the vial container. A tubular seal portion is configured to encircle the truncated cone portion and firmly engage an inside wall of the vial container with ease of insertion. A center flap portion is circumscribed by a channel at its top surface for penetration by the pipette and has a flex portion. The center flap portion separates around the perimeter of the channel but hinges at the channel above the flex portion and does not become dislodged. The ratio of the diameters of the pipette and the center flap portion is such that significant problems related to back-pressure and vacuum conditions do not exist during transfer of the containment fluid.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: November 3, 2015
    Assignee: ASTRAZENECA AB
    Inventor: Matthew Boeckeler
  • Patent number: 9107652
    Abstract: An automated sample aspirating method in which a magnetic force is applied to a collection tube containing a sample carrier to move at least the top of the carrier to a location off the center axis of the collection tube. An aspirator is inserted into the tube at a vertical position along the sample carrier, and a fluid is aspirated from the tube. Also provided are a sample collector having a tip adapted to obtain a sample from a sample source, and a handle that extends from the tip and is magnetic at a location remote from the tip. Also provided is a sample processing system having a sample collector such as described above, a collection tube adapted to hold the sample collector with the tip at a closed lower end of the tube and the handle extending towards an open upper end of the tube, and a cap that seals the sample collector tip and at least a portion of the handle inside the tube.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: August 18, 2015
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: Yancy Kenan Ragin, Bert Jungheim
  • Patent number: 9103807
    Abstract: A rack collecting unit including: a transport path capable of transporting a sample rack in a first direction; a transport path capable of transporting the sample rack in a second direction opposite to the first direction; a storing section for storing therein the sample rack; and a transferring section for transferring the sample rack carried onto the transport paths to the storing section.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: August 11, 2015
    Assignee: SYSMEX CORPORATION
    Inventors: Nobuhiro Kitagawa, Yuichiro Ohmae
  • Patent number: 9097690
    Abstract: In a large-scale analyzing system arrangement with a multi-sample processing capability, connecting a plurality of analyzing systems each having a minimum analyzer configuration makes it difficult for each analyzing system to continue analysis while managing and sharing the consumables information required for measurement between the analyzers. Additionally, since the sample preprocessing and conveying system does not recognize operational states of the analyzing systems during the analysis, conveyance of the sample to an analyzing system unable to conduct the analysis is likely to occur, resulting in delays in reporting the test results on the sample. The internal operational status of a plurality of analyzing systems is collectively managed and samples are conveyed between the analyzing systems. If the analysis is determined not to be capable of being continued, the sample is temporarily placed in a stand-by condition and then the analysis, after returning to a restartable state, is automatically continued.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: August 4, 2015
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Shigeru Yano, Atsushi Suzuki, Yasushi Aoki, Tatsuya Fukugaki
  • Patent number: 9091671
    Abstract: Arrangement enables liquid suction with a nozzle tip end in contact with a container bottom without causing damage to the nozzle and/or container bottom. Plural rails are disposed to extend upward from an arm which is movable three-dimensionally, so as to extend upward from the arm, and a pipe is fixed to a pipe fixing member movable along the rails. A pipe tip end functions as a nozzle. Plural resilient members disposed on the arm correct the inclination of the pipe fixing member. When the arm is moved downward and the tip end comes in contact with the bottom of the container 106, the pipe and the pipe fixing portion move upward along the rails, so that the pipe tip end can be brought into contact with the bottom surface of the container while avoiding damages in the pipe and container bottom, and to suck liquid in the container.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: July 28, 2015
    Assignee: Hitachi, Ltd.
    Inventors: Masahiro Okanojo, Hideyuki Noda
  • Patent number: 9086353
    Abstract: An optical instrument (10) has a drop-supporting surface for receiving a droplet (98) of liquid with a cover (16) mounted on the housing (12) which receives a light source and provides communication between the light source (114) and the inner surface of the cover. A loading aperture (24) extending through the cover permits access to the drophead when the cover is in a first rotational loading position, and the cover may be rotated to a measurement position in which the light source is positioned to illuminate the drop-supporting surface. A positioning mechanism provided between the cover an the housing engages the cover when it reaches the measurement position and thereby ensures that the light source and drop-supporting surface are maintained in fixed spaced-apart relationship.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: July 21, 2015
    Inventors: Norman McMillan, Martina O'Neill, Kevin Arthure, Stuart Smith
  • Patent number: 9073052
    Abstract: A laboratory liquid handling system includes a pipetting module, a lab member, and a drive system. The pipetting module includes a pipettor including a pipettor shaft and a pipetting tip extending from an end of the pipettor shaft. The lab member includes a body and at least one adapter structure including an interlock feature configured to laterally receive and interlock with the pipettor shaft to releasably secure the lab member to the pipettor shaft. The drive system is operable to: selectively move the pipettor shaft laterally relative to the interlock structure to engage the pipettor shaft with the interlock structure to secure the lab member to the pipetting module; move the pipetting module to transport the lab member secured thereto; and selectively move the pipettor shaft laterally relative to the interlock structure to disengage the pipettor shaft from the interlock structure to thereby release the lab member.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: July 7, 2015
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventors: Eugene S. Maslana, Karen A. McElroy, Dennis F. Malkowski, James W. Sim
  • Patent number: 9063099
    Abstract: The present invention relates to a system (10, 100) for handling slides, including an input compartment (14) for inputting racks (16) and the slides held therein, and a coverslipper module (30, 32) for coverslipping slides. The system (10, 100) further includes an output compartment (22) for outputting racks (16), a transport unit (20) for transporting the racks (16), and a control unit (52) for controlling the transport unit (20). The transport unit (20) is designed to be capable of transporting the racks (16) between the input compartment (14), the coverslipper module (30, 32) and the output compartment (22).
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: June 23, 2015
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBH
    Inventors: Bernhard Neef, Simon Keimer, Karl-Heinz Westerhoff
  • Patent number: 9063103
    Abstract: It is described a conveyor of specimen containers (9) supported by carriers (8) in laboratory automation systems comprising at least one analyzer (10, 50, 60). Said conveyor comprising a main transport unit (2), at least one spur transport unit (4-5, 7) allowing the positioning of the specimen container (9) inside said at least one analyzer (10, 50, 60) without removing said specimen container (9) from its carrier (8).
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: June 23, 2015
    Assignee: INPECO HOLDING LTD.
    Inventor: Gianandrea Pedrazzini
  • Patent number: 9057672
    Abstract: Sample application systems can include an extraction mechanism to remove a sample from sample containers, a sample vessel disposed on a deployment mechanism, where the deployment mechanism is arranged to move the sample vessel to receive a sample, an extraction mechanism washing station to wash the extraction mechanism, a sample applicator to remove a portion of the sample in the sample vessel and apply it onto a sample carrier, where the deployment mechanism can move the sample vessel to a sample application position, a sample vessel washing station to wash the sample vessel, where the deployment mechanism can move the sample vessel to the sample vessel washing station, a sample applicator washing station to wash the sample applicator after the sample has been dispensed onto the sample carrier, and a fluid control system to control flow of a fluid provided to the extraction mechanism and the sample applicator.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: June 16, 2015
    Assignee: Roche Diagnostics Hematology, Inc.
    Inventors: Brian J. McKeen, Eric D. Yeaton, James L. Dowling
  • Patent number: 9058636
    Abstract: A computer-implemented method for labeling and tracking a pathology specimen after collection and positive patient identification comprises the step of creating a pathology specimen record with a unique specimen identification code for at least one specimen. The method further includes the step of creating a label for application to a container holding the specimen, wherein the label includes the unique specimen identification code and creating an order with a unique accession number after the container is forwarded for processing, by scanning the label. The unique identification code is utilized for tracking purposes to ensure that pathology specimens for the positively identified patient are not lost in transit to the pathology laboratory for further processing. This improves quality to the patient by the elimination of transcription errors, identification of missing or lost specimens, and confirmation that pathology specimens are correctly matched to a patient.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: June 16, 2015
    Assignee: Lattice Incorporated
    Inventors: Brian K. Schwarz, Raymond J. Bender, Patrick J. Heniff
  • Patent number: 9052300
    Abstract: A method of determining a condition of clot carryout from a sample container containing a sample fluid is disclosed. During aspiration of a fluid sample (e.g., blood), a level sensor, such as a capacitance sensor, is used to measure ascending and descending liquid level readings. A difference between the ascending and descending liquid level readings may be compared to a predetermined threshold. Non-ideal conditions, such as a clot carryout condition wherein a clot is carried out of the sample container on the exterior surface of the probe may be detected thereby. Systems and apparatus for carrying out the method are provided, as are other aspects.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: June 9, 2015
    Inventors: Alexander Vidlak Evers, Bridgett Angela Harris, Alexander Openstone, Jeffrey Kenneth Parmer
  • Patent number: 9040303
    Abstract: An apparatus for measuring a volume of fluid includes at least one emitter configured to project a signal toward a predetermined position of a sample container, at least one receiver configured to receive the signal after the signal interacts with the sample container and a fluid transfer device in communication with the receiver and sample container. A change in the signal received by the receiver indicates when the fluid has dropped below the predetermined position. The apparatus determines a volume of fluid that the fluid transfer device has removed from the sample container when the receiver detects that the fluid has dropped below the predetermined position.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: May 26, 2015
    Assignee: Argos Therapeutics, Inc.
    Inventors: Simon Jonathon Spence, Richard Alexander Grant
  • Patent number: 9034278
    Abstract: A sample is cleaned up for spectroscopic analysis by receiving a slide substrate having the sample thereon, fixing the sample to a substrate surface of the slide substrate by applying heat to the slide substrate for a predetermined heating time and incubating the sample on the slide substrate for a predetermined incubation time after fixing the sample to the slide substrate. The sample is further cleaned by washing the sample on the slide substrate after the sample has been incubated and drying the sample by applying heat to the slide substrate for a predetermined drying time, wherein the sample on the slide substrate after drying has retained particles of interest and interferant particles are removed from the substrate. A substrate is also provided for sample collection, which is culturable and Raman silent.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: May 19, 2015
    Assignee: Battelle Memorial Institute
    Inventors: Andrew P. Bartko, Johnway Gao
  • Patent number: 9028755
    Abstract: A specimen transport apparatus according to an aspect is provided with a holder which holds a cup-like specimen container accommodating a specimen in an upright position, a chain member disposed along a predetermined transport path, and a supporting portion provided in a predetermined position on the chain member and configured to support the holder.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: May 12, 2015
    Assignee: Aoi Seiki Co., Ltd.
    Inventor: Teruaki Itoh
  • Patent number: 9028754
    Abstract: A rack robot lifts and transfers sample tube storage racks or plates with a refrigerated enclosure maintained, e.g., at ?20° C. The samples are normally held in ultra-low temperature, e.g., ?80° C., or cryogenic freezers. From time to time, the racks or plates need to be roved from the ultra-low temperature or cryogenic freezers for processing and the rack robot transfers the racks or plates to the various processing stations within the refrigerated enclosure, such as tube picking, barcode reading, or frost removal stations.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: May 12, 2015
    Assignee: Hamilton Storage Technologies, Inc.
    Inventors: Fabian Winter, Halvard Solberg, Julian Warhurst, Frank Hunt, Behrouz Zandi
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 9028778
    Abstract: The present disclosure provides methods for carrying out Romanowsky-type stains, specifically Wright-Giemsa and May-Grünwald stains, quickly and efficiently. The methods greatly reduce the overall amount of time required to complete a Wright-Giemsa stain or a May-Grünwald stain of sufficient quality on a biological sample. The subject methods can be applied to both manual and automated staining procedures.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: May 12, 2015
    Assignee: Abbott Laboratories
    Inventors: Abe S. Mamaghani, Koshy T. Chacko, Rupa Rao, Rene Nieves
  • Patent number: 9023279
    Abstract: A self-contained assay facility housed in a fixed-wing or rotary wing aircraft that is completely equipped to melt and assay precious metals, particularly gold and silver. An induction furnace melts the metal that is then poured into an ingot. The ingot is weighed and analyzed using an XRF alloy analyzer and the percentage of gold and/or other metals recorded. The value of the gold at current market prices is calculated and the assay and the value of the ingot is printed and given to the seller. The seller may opt to receive the ingot and pay the assayer an assay fee. Alternately, the seller may ask to be paid in cash, in bullion, by wire transfer, or by an open hedge. A transfer or hedge is initiated and confirmed from the assay facility. The ingots are securely stored in a safe within the assay facility.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: May 5, 2015
    Assignee: AOW Holdings, LLC
    Inventor: Chris M. Noyes
  • Patent number: 9023278
    Abstract: A device (600) for performing at least part of an analytical process comprises a communicator (605) to facilitate communication with the device, and a data handler (610) to handle data of the analytical process and/or the device. In an embodiment, the device (600) is a consumable device and/or a microfluidic device. A method for performing at least part of an analytical process using a device comprises the steps of: (a) introducing a sample into the device; (b) handling data associated with the test using a data handler of the device; and (c) facilitating communications about the test using a communicator of the device. In another embodiment, the method is performed using a consumable device and/or a microfluidic device.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: May 5, 2015
    Inventor: Micah James Atkin
  • Patent number: 9023655
    Abstract: Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: May 5, 2015
    Assignee: IBIS Biosciences, Inc.
    Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
  • Publication number: 20150118757
    Abstract: A sample testing system comprising: a transporting apparatus; a testing apparatus for obtain a sample and performing testing on the obtained sample; and a controller. The controller executes operation of: controlling the transporting apparatus so as to transport the sample rack in first direction, such that each sample container held in a sample rack is transported to a obtaining position on which the testing apparatus obtains a sample and then the sample rack is transported toward the second position; changing, when retesting of a sample contained in a sample container is necessary, the transporting direction from the first direction to second direction, and then controlling the transporting apparatus so as to transport the sample container accommodating the sample, for which retesting is necessary, to the obtaining position again. Sample testing method and a computer program product are also disclosed.
    Type: Application
    Filed: December 30, 2014
    Publication date: April 30, 2015
    Inventors: Yuichi HAMADA, Daigo FUKUMA
  • Publication number: 20150111288
    Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.
    Type: Application
    Filed: October 1, 2014
    Publication date: April 23, 2015
    Inventors: Brian D. Wilson, David L. Anderson, Matthew D. Erickson, Alan N. Johnson, Michael J. Rosen, Daniel R. Schmidt, Joshua D. Wiltsie
  • Patent number: 9011773
    Abstract: An automated smear making apparatus used to prepare and smear samples on glass slides. In one embodiment, there is provided a smearing subsystem that generally includes a smear cartridge having: an input reel; at least one roll bar; a take-up reel; and a smearing tape. The smearing tape is initially wound within the input reel and coupled to the take-up reel such that the smearing tape can be drawn from the input reel and into the take-up reel. The smearing tape may include a plurality of perforations formed therein. The smearing tape may then be wrapped around the roll bar such that each of the plurality of perforations forms a blade that extends from the smearing tape to expose a smear surface as the smearing tape is drawn into the take-up reel. Alternatively, the smearing tape may be bent such that an edge of the smearing tape forms a smear surface between two roll bars. A slide transport surface is also provided to move a slide across the smear surface.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: April 21, 2015
    Assignee: Abbott Laboratories
    Inventors: John Scott Shoffner, Koshy T. Chacko, Roei Solomon
  • Patent number: 9011770
    Abstract: The present invention provides a device for detecting the presence of an analyte in a liquid sample. The device has an opening for introducing the liquid sample into a first chamber for collecting the liquid sample, and a second chamber connected to the first chamber by a passageway and containing a test element. The device also has a third chamber connected to the second chamber by a channel and containing a movable member having first and second positions. The third chamber is divided by the movable member into first and second zones, and the first zone has a vent hole. The movable member is in contact with at least one wall of the third chamber to prevent gas communication between the first and second zones.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: April 21, 2015
    Assignee: Alere Switzerland GmbH
    Inventors: Yuzhang Wu, Haipeng Hu, Jielin Dai, Lijian Gou
  • Patent number: 9005525
    Abstract: A transportable, self-contained assay facility built in a modified standard shipping container that is completely equipped to melt and assay precious metals, particularly gold and silver. An induction furnace melts the metal that is then poured into an ingot. The ingot is weighed and analyzed using an XRF alloy analyzer and the percentage of gold and/or other metals recorded. The value of the gold at current market prices is calculated and the assay and the value of the ingot is printed and given to the seller. The seller may opt to receive the ingot and pay the assayer an assay fee. Alternately, the seller may ask to be paid in cash, by bullion, wire transfer, or by an open hedge. A transfer or hedge is initiated and confirmed from the assay facility. The ingots may be securely stored in a safe within the assay facility.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: April 14, 2015
    Assignee: AOW Holdings, LLC
    Inventors: Chris M. Noyes, Walter Nadonza
  • Patent number: 9005980
    Abstract: A method including automatically displaying information obtained from a first identifier associated with a slide and a second identifier associated with a reagent cartridge. The method further including generating a staining log based on the information obtained from the first identifier and the second identifier. A further method includes displaying a location of a slide within a sample processing system and information obtained from a first identifier associated with the slide in a first table and displaying a location of a reagent cartridge within a sample processing system and information obtained from a second identifier associated with the reagent cartridge in a second table. The first table is then aligned with the second table.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: April 14, 2015
    Assignee: Sakura Finetek U.S.A., Inc.
    Inventors: Robert E. Evans, Anthony L. Hartman, Richard A. Suchter, Gilles Lefebvre
  • Patent number: 8999270
    Abstract: An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: April 7, 2015
    Assignee: BioPath Automation, L.L.C.
    Inventors: Warren P. Williamson, IV, Stephen P. Whitlatch
  • Patent number: 8999269
    Abstract: The present invention relates to a glass plate (2) for use in a device (1) for stretching sample sections having a sectioning knife, the glass plate (2) being arranged at the back (3) of the sectioning knife in such a way that a defined gap (4) for reception of the sectioned sample is formed between the back (3) of the sectioning knife and the plate (2), the glass plate (2) possessing, at least on one of its longitudinal sides (21, 22), edges (211, 212; 221, 222) ground and polished to optical flatness.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: April 7, 2015
    Assignee: Leica Microsystems CMS GmbH
    Inventors: Ralf Unger, Frank Eisenkrämer
  • Publication number: 20150093290
    Abstract: A sample sorting apparatus configured to transfer a sample container from a sample rack supporting the sample container to a storage rack. The sample sorting apparatus comprises a storage part configured to allow a plurality of storage racks to be placed thereon, a sample container gripper configured to grip a sample container supported in a sample rack, a movement mechanism configured to move the sample container gripper, and an identification information reader provided so as to be movable together with the sample container gripper by the movement mechanism. The identification information reader is configured to read, from an identifier attached to each of the plurality of storage racks stored in the storage part, identification information for identifying the storage rack.
    Type: Application
    Filed: September 24, 2014
    Publication date: April 2, 2015
    Inventors: Kei TAKAI, Hiroo TATSUTANI
  • Patent number: 8992863
    Abstract: A tissue processing system includes a plurality of processing stations. Each processing station includes a plurality of tissue receiving areas that are each configured to accommodate a tissue sample as well as physically isolate that tissue sample from other tissue samples at other receiving areas of the same processing station. Each processing station is configured to separately and individually process the tissue sample at each receiving area to either reduce or eliminate any potential for cross-contamination between the tissue samples undergoing processing at the same processing station. For each receiving area of each processing station, the system is configured to immerse a tissue sample at a particular receiving area in processing fluid for a pre-determined time according to a pre-defined protocol that is based upon parameters of that tissue sample.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: March 31, 2015
    Assignee: Rushabh Instruments, Inc.
    Inventor: Preyas Shah
  • Patent number: 8986614
    Abstract: A self-contained, fully automated, biological assay-performing apparatus includes a housing; a dispensing platform including a controllably-movable reagent dispensing system, disposed in the housing; a reagent supply component disposed in the housing; a pneumatic manifold removably disposed in the housing in a space shared by the dispensing platform, removably coupled to a fluidic transport layer and a plurality of reservoirs, wherein the fluidic transport layer, the reservoirs, and a test sample to be introduced therein are disposed in the housing in the space separate from the dispensing platform; a pneumatic supply system removably coupled to the pneumatic manifold in the housing in a space separate from the dispensing platform; and a control system coupled to at least one of the dispensing platform and the pneumatic supply system, disposed in the housing.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 24, 2015
    Assignee: Rheonix, Inc.
    Inventors: Peng Zhou, Lincoln C. Young, Benjamin Thomas, Zongyuan Chen, Todd Roswech, Gwendolyn Spizz, Rubina Yasmin, Greg Mouchka
  • Patent number: 8986611
    Abstract: A sample analysis apparatus configured to automatically press a start button upon installation of a sample tube is provided. The sample analysis apparatus includes: a body of the sample analysis apparatus; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge; a tube accommodating unit included in the door housing and configured to accommodate the sample tube; a start button included in the body of the sample analysis apparatus and configured to start analysis of the sample; and an operating member positioned at a first position which is distant from the start button the sample tube is not installed in the tube accommodating unit, and a second position which is configured to operate the start button when a sample tube is installed and the door housing is closed.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: March 24, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yong Koo Lee, Tae Soo Kim, In Duk Hwang, Seock Woo Jang, Chul Ho Yun
  • Publication number: 20150075298
    Abstract: An accommodating magazine for accommodating a plurality of sample carriers in a sample holder for use in an input or output area of an automated sample handling device. The magazine comprises a magazine panel a detection device for detecting whether the panel is filled with sample holders or sample carriers during movement of the panel between a loading position and a ready position. The detection device includes at least one contactless detector for detecting the presence of objects in a sensor area, a path sensor, which detects a displacement path or current position of the panel during displacement of the panel between the loading and ready positions; and an evaluating unit in which the detector data and the path sensor data are merged and are evaluated.
    Type: Application
    Filed: January 18, 2013
    Publication date: March 19, 2015
    Applicant: GLP Systems GmbH
    Inventor: Robert Hecht
  • Publication number: 20150079684
    Abstract: A tube rotator for rotating test tubes arranged in a tube rack as well as a system and process for reading information of machine-readable labels of the test tubes are disclosed. The tube rotator may comprise a pivoted lever having two lever arms, a friction wheel rotatably fixed to one lever arm and arranged to be brought in or out of contact with at least one test tube for rotating the test tube by friction. A first actuator may be rotatably coupled to the friction wheel, and a pretensioner which is capable of generating a pretensioning force may act on the lever for pivoting the lever in one pivoting direction. An eccentric may be rotatably fixed with respect to the base and arranged to roll off the other lever arm for pivoting the lever in another pivoting direction. A second actuator may be rotatably coupled to the eccentric.
    Type: Application
    Filed: August 26, 2014
    Publication date: March 19, 2015
    Inventors: Marco Bucher, David Huber