Including Titrator Patents (Class 422/75)
  • Patent number: 10295458
    Abstract: An analytical device for determining a parameter of a liquid sample, especially a digestion parameter, such as chemical oxygen demand, total carbon content or total nitrogen content, comprising a reactor, and measuring system for ascertaining the parameter of the liquid sample. A container system for storing samples, reagents and waste products in containers, a transport and dosing system for metering and transporting the sample and reagents from the containers into a metering container and for disposal of waste products from the metering container into a waste container, and a measuring transducer for registering a measured parameter correlating, measured value of the liquid sample mixed in the reactor, and measuring, system, in given cases, with one or more reagents is provided.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: May 21, 2019
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventors: Marco Volker, Sofia Reim, Anja Gerlinger, Xu Zhou
  • Patent number: 10018610
    Abstract: A method for determining the total alkalinity (TA) in a recirculating water system without adversely impacting the pH of the water includes the steps of selecting a pH threshold (ThpH), measuring the flow rate of the moving body of water (fS), controllably adding a known amount of acid to the recirculating water system at an acid flow rate (fA), repetitively measuring the pH of the recirculating water system downstream from the addition of the acid, and computing the total alkalinity of the recirculating water system when the pH measurement falls below the pH threshold.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: July 10, 2018
    Assignee: BECS TECHNOLOGY, INC.
    Inventors: Roger Chamberlain, Chris Edmiston, Brett Steinbrueck, Don Williams
  • Patent number: 9028756
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Patent number: 8986611
    Abstract: A sample analysis apparatus configured to automatically press a start button upon installation of a sample tube is provided. The sample analysis apparatus includes: a body of the sample analysis apparatus; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge; a tube accommodating unit included in the door housing and configured to accommodate the sample tube; a start button included in the body of the sample analysis apparatus and configured to start analysis of the sample; and an operating member positioned at a first position which is distant from the start button the sample tube is not installed in the tube accommodating unit, and a second position which is configured to operate the start button when a sample tube is installed and the door housing is closed.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: March 24, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yong Koo Lee, Tae Soo Kim, In Duk Hwang, Seock Woo Jang, Chul Ho Yun
  • Patent number: 8980636
    Abstract: A system and method for performing automated titrations. An automatic titrator utilizes control devices and sensors adapted for various chemical reactions to perform titrations and determine the content of a desired component of a solution. Batch and continuous mode titrations are possible. Titrant is added to a sample either in varying amounts or rates and a titration endpoint is observed via sensors. Control devices detect when the titration endpoint occurs and calculates the desired content. Various reactions within the solution may be suppressed in order to titrate isolated components individually.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 17, 2015
    Assignee: Ecolab USA Inc.
    Inventors: John Wilhelm Bolduc, Blake Roberts Otting, Paul R. Kraus, Robert Ryther
  • Publication number: 20150064732
    Abstract: An analytical test cartridge is provided. The analytical test cartridge can be used for medical analyses of liquid samples removed from a patient, for example blood. The analytical test cartridge is configured to provide for titration experiments. An example of a titration experiment that can be performed with the arrangement, is titration of heparin with protamine. Methods of assembly and use are provided.
    Type: Application
    Filed: February 28, 2014
    Publication date: March 5, 2015
    Inventor: Kee Van Sin
  • Publication number: 20150065370
    Abstract: The present invention provides a method for determining radioactivity in an ion-sensitive field effect transistor array, the method comprising the steps of incubating the array with electron-sensitive silver-halide material and then incubating the array with a developer solution reducing the silver halides that have been exposed to radioactivity to elemental silver and simultaneously measuring pH at each separate reaction chambers, wherein decrease of the pH indicates the presence of radioactivity in a reaction chamber.
    Type: Application
    Filed: March 19, 2013
    Publication date: March 5, 2015
    Inventors: LLari Maasilta, Marja Tiirola
  • Patent number: 8945939
    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: February 3, 2015
    Assignee: Ecolab USA Inc.
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert Mack
  • Patent number: 8932874
    Abstract: The invention is directed towards methods and compositions for identifying the amount of ammonium acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of ammonium acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of ammonium acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the ammonium acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: January 13, 2015
    Assignee: Nalco Company
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert M. Mack
  • Publication number: 20140227791
    Abstract: A method and system for testing the functional capability of an analytical instrument uses first and second blind samples. Each blind sample is a test substance with an amount of a parameter to be tested that is unknown to the user. Each blind sample is provided with an identification means with a unique identification. When the blind samples are tested by the user in the instrument being tested, the measurement values obtained and the unique identifications read are compared against predetermined values that are accessible to a test program configured as software on the analytical instrument. By comparison of the measurement values and the predetermined values, the functional capability of the analytical instrument is determined and the result is transmitted to an output unit of the analytical instrument.
    Type: Application
    Filed: February 12, 2014
    Publication date: August 14, 2014
    Inventors: Christian Walter, Félix Bécheiraz, Manuela Gerber, Rolf Rohner
  • Patent number: 8716028
    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: May 6, 2014
    Assignee: Nalco Company
    Inventors: Amy Tseng, Brian V. Jenkins, Robert M. Mack
  • Patent number: 8709815
    Abstract: Methods and devices are disclosed providing techniques for measuring the amount of biodiesel in a fuel sample. The methods may be used in the field without the use of laboratory equipment. The biodiesel in the sample is converted to the corresponding free acid which can be isolated and quantified to provide information regarding the amount of biodiesel in the original sample.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: April 29, 2014
    Assignee: Dexsil Corporation
    Inventors: Theodore B. Lynn, Lawrence M. Sacramone
  • Publication number: 20140106464
    Abstract: Method for analyzing the alkalinity conditions in aqueous liquids, comprising: sampling a known amount of the aqueous liquid and placing it in a container of known volume, measuring pH in the sampled liquid and pressure in the container, adding a known amount of CO2 to the sampled liquid, and measuring pH in the sampled liquid and the pressure in the container, and finally calculating the total alkalinity based on the values from the performed measurements. An apparatus for conducting the method is also described as well as a method for controlling chemistry of a glycol containing liquid in a system for recovery of glycol.
    Type: Application
    Filed: May 11, 2012
    Publication date: April 17, 2014
    Inventors: Arne Dugstad, Marion Seiersten
  • Patent number: 8545760
    Abstract: A specimen analyzing method and a specimen analyzing apparatus capable of measuring interference substances before analyzing a specimen. The method comprises a step for sucking the specimen stored in a specimen container (150) and sampling it in a first container (153), a step for optically measuring the specimen in the first container, a step for sampling the specimen in a second container (154) and preparing a specimen for measurement by mixing the specimen with a reagent in the second container, and a step for analyzing the specimen for measurement according to the results of the optical measurement of the specimen.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: October 1, 2013
    Assignee: Sysmex Corporation
    Inventors: Norimasa Yamamoto, Takashi Yamato, Naohiko Matsuo, Satoshi Iguchi
  • Publication number: 20130109102
    Abstract: A system and method for protein separation and purification includes a mixing loop, a primary pump having an inlet in communication with a supply of an acid or an alkali and an outlet in communication with the mixing loop. A concentrate pump has an inlet in communication with a supply of an acid or an alkali and an outlet in communication with the mixing loop. A liquid chromatography column is in communication with the mixing loop and is packed with an ion exchange resin and loaded with a protein solution containing a first protein having a first isoelectric point and a second protein having a second isoelectric point. A process control feedback loop in communication with the mixing loop includes an inline process pH analyzer so that a pH of a titration solution in the mixing loop may be detected and adjusted based on the detected pH.
    Type: Application
    Filed: September 20, 2011
    Publication date: May 2, 2013
    Inventors: HIROYUKI YABE, TOMOYUKI MIYABAYASHI
  • Patent number: 8377375
    Abstract: The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivate microorganisms present in a biological fluid, preferably a non-transparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: February 19, 2013
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Heinz Anderle, Peter Matthiessen, Hans-Peter Schwarz, Peter Turecek, Thomas Kreil, Daniel R. Boggs
  • Patent number: 8349614
    Abstract: Alkalinity determination, including an alkalinity determination process and/or alkalinity determinator. An alkalinity determination process may include providing a known value of volume of an acidic fluid, forming a titration system by providing one or more additions of a known value of volume of a relatively alkaline fluid to an acidic fluid, determining a pH value and/or a temperature value for one or more additions and/or determining an alkalinity value of a system by calculating a transformation including one or more determined pH values and/or temperature values of one or more additions. An alkalinity determination process may include modeling, such that an informed determination may be made with reference to relevant and/or irrelevant factors, as well as parameters to maximize likelihood of alkalinity determination. In embodiments, an alkalinity determinator may include one or more titration cells, one or more sensors and/or one or more alkalinity value determinators.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: January 8, 2013
    Assignees: George Mason Intellectual Properties, Inc., University of South Carolina
    Inventors: Christopher Hintz, Kenneth J. Hintz
  • Patent number: 7988916
    Abstract: An apparatus and method for measuring a range of small volumes of fluids to a high degree of precision, said apparatus including: a) a single reaction chamber (20); b) a piston (30) operable within said chamber to selectively and precisely vary the internal volume of said chamber; c) a first inlet (41) to said chamber in communication with one or more fluid sources of which a portion of a first fluid of said one or more fluids is adapted to be drawn into said chamber; d) at least one further inlet (43) including a second inlet to said chamber in communication with one or more fluid sources of which a portion of a second fluid of said one or more fluids is adapted to be drawn into said chamber; and e) a sealable outlet (45), wherein said piston is adapted to progressive draw said portion of a second fluid into said chamber until either accurare metering of a volume of said first or second portion of fluid is achived or a reaction involving said first and second portions in said chamber (such as a titration rea
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: August 2, 2011
    Inventor: Ben Bremauer
  • Patent number: 7968053
    Abstract: A chlorine analyzing apparatus includes a reaction tube of a double tube structure with an inner tube for receiving a sample and an outer tube for recovering hydrogen chloride. An electric furnace has a reaction tube insertion hole into which the reaction tube is inserted. The electric furnace is equipped with a heater disposed around the reaction tube insertion hole. A titration cell receives acetic acid as an electrolyte and subjects hydrogen chloride withdrawn from the reaction tube to coulometric titration. A deodorization tube is disposed on a rear stage side of the titration cell for thermally decomposing a vapor of acetic acid discharged from the titration cell. The deodorization tube is fitted into the electric furnace.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: June 28, 2011
    Assignee: Mitsubishi Chemical Analytech Co., Ltd.
    Inventors: Norio Hayashi, Takayuki Okafuji, Tamaki Tomoyose, Shuichi Akasaka
  • Patent number: 7932094
    Abstract: The stability of an electroless plating bath for depositing a metal (e.g., nickel) is determined by titrating a sample of the plating bath with a titrant comprising ions of a catalytic metal (e.g., palladium) and detecting hydrogen released at the titration endpoint. The quantity of titrant required to attain the endpoint provides a measure of the stability of the electroless plating bath.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: April 26, 2011
    Assignee: ECI Technology, Inc.
    Inventors: Eugene Shalyt, Semyon Aleynik, Peter Bratin
  • Publication number: 20100304496
    Abstract: The present invention is embodied in a method for precisely dispensing fluid, including treating an orifice of a fluid dispensing apparatus during a fabrication process by applying a low surface energy material layer onto the orifice, adjusting a thickness of the low surface energy material coating to a predetermined threshold and limiting backpressure of a low dead volume fluid delivery system coupled to the orifice to reduce interference or interruptions for precisely dispensing the fluid.
    Type: Application
    Filed: June 1, 2009
    Publication date: December 2, 2010
    Inventors: Jeffrey A. Nielsen, Jeremy Hartan Donaldson, Benjamin Clark, Debora J. Thomas
  • Publication number: 20100247379
    Abstract: A reagent preparing apparatus capable of being connected to a sample measuring section for measuring a sample using a diluted reagent prepared by the reagent preparing apparatus, comprising: a reagent preparing section for preparing a diluted reagent containing a predetermined reagent and pure water; a pH measuring section for measuring hydrogen ion concentration of the diluted reagent prepared by the reagent preparing section; and a controller for performing predetermined processing, wherein the controller is configured to change the process to be performed based on the hydrogen ion concentration measured by the pH measuring section, is disclosed. A sample analyzer is also disclosed.
    Type: Application
    Filed: March 22, 2010
    Publication date: September 30, 2010
    Inventor: Carola Schmidt
  • Publication number: 20100210026
    Abstract: Alkalinity determination, including an alkalinity determination process and/or alkalinity determinator. An alkalinity determination process may include providing a known value of volume of an acidic fluid, forming a titration system by providing one or more additions of a known value of volume of a relatively alkaline fluid to an acidic fluid, determining a pH value and/or a temperature value for one or more additions and/or determining an alkalinity value of a system by calculating a transformation including one or more determined pH values and/or temperature values of one or more additions. An alkalinity determination process may include modeling, such that an informed determination may be made with reference to relevant and/or irrelevant factors, as well as parameters to maximize likelihood of alkalinity determination. In embodiments, an alkalinity determinator may include one or more titration cells, one or more sensors and/or one or more alkalinity value determinators.
    Type: Application
    Filed: February 17, 2010
    Publication date: August 19, 2010
    Inventors: Christopher Hintz, Kenneth J. Hintz
  • Patent number: 7776601
    Abstract: The invention concerns a method which consists in determining ageing an ageing index of a blood bag (11, 62), to determine whether the blood bag is or not suitable for transfusion to a patient. The ageing index is calculated by connecting a silicon chip provided with a loop antenna integral with the blood bag (11, 62) with an electronic communication device (2, 8, 17, 12, 20, 24), itself equipped with a loop antenna, connected to a computer (9, 13) containing appropriate computing software elements. Said ageing index is regularly calculated at the blood transfusion center (16) from the sample (1), until it is removed from storage (7) to be sent to the health-care institution (18) and to the operating theatre (19).
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: August 17, 2010
    Assignee: Biolog
    Inventors: Antoine De Gaulle, Jean-Claude Mongrenier
  • Publication number: 20100202925
    Abstract: The invention relates to a sample device (1) comprising an array of reaction chambers/wells (3) in a titer plate (2) and a two-dimensional array (10) of thin-film-light sensor elements (12), and each light-sensitive element (12) of the sensor array (10) is disposed directly underneath the individual reaction chamber (3) in order to detect chemical and/or biological reactions.
    Type: Application
    Filed: November 8, 2007
    Publication date: August 12, 2010
    Applicant: NANOIDENT TECHNOLOGIES AB
    Inventor: Max Sonnleitner
  • Publication number: 20100035356
    Abstract: The stability of an electroless plating bath for depositing a metal (e.g., nickel) is determined by titrating a sample of the plating bath with a titrant comprising ions of a catalytic metal (e.g., palladium) and detecting hydrogen released at the titration endpoint. The quantity of titrant required to attain the endpoint provides a measure of the stability of the electroless plating bath.
    Type: Application
    Filed: August 7, 2008
    Publication date: February 11, 2010
    Inventors: Eugene Shalyt, Semyon Aleynik, Peter Bratin
  • Publication number: 20100029011
    Abstract: An analytical test cartridge is provided. The analytical test cartridge can be used for medical analyses of liquid samples removed from a patient, for example blood. The analytical test cartridge is configured to provide for titration experiments. An example of a titration experiment that can be performed with the arrangement, is titration of heparin with protamine. Methods of assembly and use are provided.
    Type: Application
    Filed: August 4, 2009
    Publication date: February 4, 2010
    Inventor: Kee Van Sin
  • Patent number: 7651860
    Abstract: Methods of analyzing low levels of peroxyacetic acid (PAA) in water are described. These methods employ buffering the PAA-containing water and the use of a N,N-diethyl-p-phenylenediamine (DPD) indicator system in the presence of iodide ion. The intensity of the pink coloration that develops is quantitated by colorimetric or titrimetric methods and correlated to the ppm PAA in the water. Positive interference effects due to the presence of hydrogen peroxide are eliminated by performing the analyses quickly after the introduction of the reagents.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: January 26, 2010
    Assignee: Enviro Tech Chemical Services, Inc.
    Inventors: Jonathan N. Howarth, Michael S. Harvey
  • Patent number: 7619053
    Abstract: A non-reactive monomer mixture has a monomer component dispersed in a melted diaryl carbonate. The monomer component has one or more monomer compounds having a melting point below the melting point of the diaryl carbonate. Furthermore, the monomer component has less than 600 ppb alkali metal, an acid stabilizer, or both less than 600 ppb alkali metal and an acid stabilizer. The monomer compounds of the monomer component and the diaryl carbonate are present in a mole ratio of from 0.9 to 1.1. The monomer mixture is at a temperature between the melting temperature of the lowest melting monomer compound and the melting temperature of the diaryl carbonate.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: November 17, 2009
    Assignee: Sabic Innovative Plastics IP B.V.
    Inventors: Hans-Peter Brack, Maarten Antoon Jan Campman, Martin Herke Oyevaar, Yohana Perez de Diego, Laurus van der Wekke, Dennis James Patrick Maria Willemse
  • Patent number: 7615605
    Abstract: A non-reactive monomer mixture contains a monomer component and a diaryl carbonate dispersed in the mixture. The monomer component includes one or more monomer compounds having a melting point below the melting point of the diaryl carbonate. The monomer component has less than 600 ppb alkali metal, an acid stabilizer, or both less than 600 ppb alkali metal and an acid stabilizer. The monomer compounds of the monomer component and the diaryl carbonate are present in a mole ratio of from 0.9 to 1.1. The monomer mixture is at a temperature between the melting temperature of the lowest melting monomer compound and less than 5° C. above the melting point of the diaryl carbonate.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: November 10, 2009
    Assignee: Sabic Innovative Plastics IP B.V.
    Inventors: Hans-Peter Brack, Maarten Antoon Jan Campman, Yohana Perez de Diego, Dennis James Patrick Maria Willemse
  • Publication number: 20090275144
    Abstract: A system for colorimetric titration, comprising a container (10); a mixing device (11), which is arranged to extend along a substantial portion of a longitudinal axis of the container (10); and an analysis arrangement (12) having a housing in the form of a collar which is adapted to fit around and at least partially enclose, a section of said container extending in a plane substantially perpendicular to the longitudinal axis of the container and not intersected by the mixing device (11) in the container (10). The collar houses at least one electromagnetic radiation source, arranged to emit electromagnetic radiation towards said container (10); and at least one electromagnetic radiation detector, arranged to detect electromagnetic radiation, emitted from the at least one electromagnetic radiation source through the container (10).
    Type: Application
    Filed: June 18, 2007
    Publication date: November 5, 2009
    Inventor: Tommy Petersson
  • Patent number: 7601794
    Abstract: A non-reactive monomer mixture is formed from a dihydroxy component having one or more dihydroxy compounds dissolved in a melted diaryl carbonate. The dihydroxy component has less than 600 ppb alkali metal, an acid stabilizer, or both less than 600 ppb alkali metal and an acid stabilizer. The dihydroxy compounds of the dihydroxy component and the diaryl carbonate are present in a mole ratio of from 0.9 to 1.1. The monomer mixture is at a temperature between the saturation point of the monomer mixture and the highest melting temperature of the individual dihydroxy compounds. The non-reactive monomer mixture can be stored and transported and then polymerized to form polycarbonate upon addition of a catalyst.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: October 13, 2009
    Assignee: Sabic Innovative Plastics IP B.V.
    Inventors: Hans-Peter Brack, Maarten Antoon Jan Campman, Yohana Perez de Diego, Martin Herke Oyevaar, Laurus van der Wekke, Dennis Willemse
  • Patent number: 7485118
    Abstract: The present invention relates to a microstructure arrangement for the bubble-free filling with a liquid of at least one system for draining off liquids. The arrangement has an inlet for the arrangement to be connected to a system for the supply of liquids and at least one outlet for the arrangement to be connected to the at least one liquid-discharging system. The arrangement has a transition region, through which the liquid can be transported from the inlet to the at least one outlet. At a start of the transition region, at least one first microstructure element for producing a point with increased capillary force is provided, in order to achieve gap-free wetting of the areas bounding this point with increased capillary force, in particular side walls, a cover and/or a bottom.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: February 3, 2009
    Assignee: Boehringer Ingelholm Microparts GmbH
    Inventors: Gert Blankenstein, Ralf-Peter Peters, Claus Marquordt
  • Publication number: 20080247265
    Abstract: The present invention provides an apparatus for the mixing or dilution of chemicals from one more sources that have been analyzed using laboratory analysis or an insitu-analyzer for concentration or molarity. The chemical is then transferred to a series of precisely calibrated vessels each of have a volume 10% of the next vessel. For example the main vessel may be 1 L in volume and the second vessel is 0.1 L in volume, the third is 0.01 L in volume and the fourth is 0.001 L in volume. The present system utilizes these two or more metered vessels which are connected to bulk chemical sources via intake lines. Each metered vessel contains an overflow tube, which drains any excess chemical by gravity flow from the metered vessel so as to adjust the chemical amount to a pre-calibrated desired level.
    Type: Application
    Filed: April 9, 2007
    Publication date: October 9, 2008
    Inventor: Daniel H. Wilcox
  • Publication number: 20080160497
    Abstract: The invention provides methods for determining the mid-value titer of a substance in a composition. In some methods the substance comprises at least one anti-hemagglutinin (HA) antibody. The invention also provides systems and computer-readable media for use in association with such methods.
    Type: Application
    Filed: August 7, 2006
    Publication date: July 3, 2008
    Inventor: Jozef J. P. Nauta
  • Patent number: 7349760
    Abstract: A system for measuring and controlling the concentration of a chemical agent in a solution has a reaction cell for receiving a sample, a titrant dropper for releasing one or more drops of titrant into the sample, a first photosensor for sensing disruptions of light for every drop of titrant released, and a controller that communicates with the photosensor and computes the concentration of the chemical agent based on the number of disruptions of light at the photosensor. The present invention also includes a method for sensing and controlling the concentration of a chemical agent in a solution. The method includes having a sample containing the chemical agent, triggering the release of a number of drops of titrant into the sample, detecting the number of drops released into the sample, and computing the concentration of the chemical agent in the sample based on the number of drops of titrant released into the sample.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: March 25, 2008
    Assignee: Ecolab Inc.
    Inventors: Guang-jong Jason Wei, Tim Gutzmann, Paul Schacht, Tom Batcher
  • Patent number: 7214537
    Abstract: A multicomponent fluid composition monitoring and compositional control system, in which a component analysis is effected by titration or other analytical procedure, for one or more components of interest, and a computational means then is employed to determine and responsively adjust the relative amount or proportion of the one or more components in the multicomponent fluid composition, to maintain a predetermined compositional character of the multicomponent fluid composition. The system is usefully employed in semiconductor manufacturing photoresist and post-etch residue removal, in which the cleaning medium is a semi-aqueous solvent composition, and water is the monitored and responsively adjusted component.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: May 8, 2007
    Assignee: Advanced Technology Materials, Inc.
    Inventors: Russell Stevens, Thomas Kloffenstein, Todd Aycock, Joseph W. Evans
  • Patent number: 7205153
    Abstract: Embodiments of the invention provide an analytical method and analytical reagent solutions for determining the concentration of electrolyte components, such as copper, acid and chloride constituents in an acid or basic metal plating bath using a chemical analyzer. Common methods for measuring the concentration of copper general require two reagent solutions/two steps. This invention provides a novel analytical reagent solution that simplifies the chelating, buffering, and cleaning functions of separate regent solutions required for measuring electrolyte concentration. This has the benefits of reducing chemical inventory and associated dispensing equipment, and thus reducing chemical consumption.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: April 17, 2007
    Assignee: Applied Materials, Inc.
    Inventor: Todd Alan Balisky
  • Patent number: 7153690
    Abstract: A multicomponent fluid composition monitoring and compositional control system, in which a component analysis is effected by titration or other analytical procedure, for one or more components of interest, and a computational means then is employed to determine and responsively adjust the relative amount or proportion of the one or more components in the multicomponent fluid composition, to maintain a predetermined compositional character of the multicomponent fluid composition. The system is usefully employed in semiconductor manufacturing photoresist and post-etch residue removal, in which the cleaning medium is a semi-aqueous solvent composition, and water is the monitored and responsively adjusted component.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: December 26, 2006
    Assignee: Advanced Technology Materials, Inc.
    Inventors: Russell Stevens, Thomas Kloffenstein, Todd Aycock, Joseph W. Evans, Richard Bhella
  • Patent number: 6783991
    Abstract: The invention is a method and system that is useful to authenticate security paper. Specifically, the present invention relates to a method and system that allows security paper to be authenticated more than once without destroying the authentication mechanism. An authenticating solution is applied to a surface of an authentic document or other authentic security paper. Subsequent application of an activating solution to a surface of a document containing the authenticating solution causes a reversible color change allowing the document to be authenticated.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: August 31, 2004
    Assignee: The Standard Register Company
    Inventors: Rajendra Mehta, Steven L. Yeager
  • Patent number: 6780646
    Abstract: The rate of carbon dioxide release from a grain sample can be measured by placing the grain sample in a sealed container, and positioning a pH responsive color-change material in the container so that carbon dioxide released from the grain sample chemically reacts with a buffer incorporated into the color-change material. Carbon dioxide measurements can be used to measure actual and potential spoilage of the grain associated with fungal attack.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: August 24, 2004
    Inventor: William F. Brinton
  • Publication number: 20040087031
    Abstract: A pH measurement system automatically measures the pH of samples in purge and trap sample concentrators, autosamplers or other sample delivery devices. The pH measurement system includes a pH sensor that is positioned in a pH sample reservoir. The pH sample reservoir may be automatically filled with sample from a sparge vessel, calibrated using liquid having known pH, or rinsed. A controller enables and disables the valves and pump to transmit the liquid to the pH sample reservoir.
    Type: Application
    Filed: November 5, 2002
    Publication date: May 6, 2004
    Inventor: Richard K. Simon
  • Publication number: 20040053417
    Abstract: A diagnostic device for use in performing clinical tests on a fluid, including a light transmitting plate and a panel adhered to and substantially covering the plate. The panel has an opening therein formed and a strip of pH testing material, substantially smaller than the panel, is fixed between the plate and the panel to fill substantially the opening, wherein the pH testing material produces a color indicative of fluid pH upon contact with the fluid. A window formed in the panel exposes a portion of the plate wherein the panel forms a wall on the perimeter of the window to confine fluid applied to the plate, within an area defined by the window.
    Type: Application
    Filed: September 14, 2002
    Publication date: March 18, 2004
    Inventors: Jerome L. Sinsky, Christopher J. Gyben
  • Publication number: 20040009606
    Abstract: There is a need within the medical community for non-invasive instruments to measure critical physiologic parameters at the point of care. Such a technique may be applicable to a wide variety of commonly monitored physiologic parameters during critical care patient management. The invention is directed to a method of measuring the pH of a patient's tissue. The method includes measuring the optical signal from a specie whose fluorescence is pH sensitive, such as nicotinamide adenine dinucleotide (NADH) and also measuring the optical signal from a second biological marker, such as FAD, the fluorescence from the second marker being substantially insensitive to pH. The method includes determining the patient's pH by using the first and second optical signals.
    Type: Application
    Filed: July 11, 2002
    Publication date: January 15, 2004
    Applicant: Optical Sensors, Inc.
    Inventors: Victor E. Kimball, Steven C. Furlong, Irvin Pierskalla
  • Publication number: 20040002161
    Abstract: An analytical test cartridge is provided. The analytical test cartridge can be used for medical analyses of liquid samples removed from a patient, for example blood. The analytical test cartridge is configured to provide for titration experiments. An example of a titration experiment that can be performed with the arrangement, is titration of heparin with protamine. Methods of assembly and use are provided.
    Type: Application
    Filed: June 28, 2002
    Publication date: January 1, 2004
    Applicant: Diametrics Medical, Inc.
    Inventor: Kee Van Sin
  • Publication number: 20030175983
    Abstract: A system for measuring and controlling the concentration of a chemical agent in a solution has a reaction cell for receiving a sample, a titrant dropper for releasing one or more drops of titrant into the sample, a first photosensor for sensing disruptions of light for every drop of titrant released, and a controller that communicates with the photosensor and computes the concentration of the chemical agent based on the number of disruptions of light at the photosensor. The present invention also includes a method for sensing and controlling the concentration of a chemical agent in a solution. The method includes having a sample containing the chemical agent, triggering the release of a number of drops of titrant into the sample, detecting the number of drops released into the sample, and computing the concentration of the chemical agent in the sample based on the number of drops of titrant released into the sample.
    Type: Application
    Filed: March 13, 2002
    Publication date: September 18, 2003
    Applicant: Ecolab, Inc.
    Inventors: Guang-jong Jason Wei, Tim Gutzmann, Paul Schacht, Tom Batcher
  • Patent number: 6537822
    Abstract: Free fluorine is measured in a hydrofluoric acid-containing solution with a coexistent metallic ion based on a total fluorine concentration, a total acid concentration, a metallic ion concentration, the equilibrium constant of hydrofluoric acid, and equilibrium constants of metal fluoride complexes. It is possible to accurately analyze free fluorine in a hydrofluoric acid-containing solution without being affected by a coexistent metal and by the passage of time. This technique may be used to accurately control the concentration of free fluorine in a hydrofluoric acid-containing mixed acid pickling solution at the production site of a stainless steel so that improvement in descaling capability as well as reduction in the amount of chemical materials can be achieved.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: March 25, 2003
    Assignee: Kawasaki Steel Corporation
    Inventors: Hisao Yasuhara, Makoto Shimura
  • Publication number: 20030032195
    Abstract: The present invention relates to a method for titration comprising guiding a sample to be titrated through a conduit, adding a reagent to said conduit at at least two entrance positions along said conduit in such a manner that said reagent will react with the sample within at least one individual sector of the conduit, defined as the space between two consecutive entrance positions or a final individual sector defined between a final entrance position and a sample exit point of the conduit, while at least one detection device positioned at the end of each sector of said conduit register the chemical and/or physical status. A pressure difference is provided between the reagent delivery device and the sample conduit such that the pressure difference measured between the reagent delivery device and the end of the final individual sector is controlled to be greater than the total pressure drop between the sample delivery point and the end of the final individual sector.
    Type: Application
    Filed: March 15, 2002
    Publication date: February 13, 2003
    Inventors: Johan Roeraade, Matthew Rice
  • Patent number: 6495372
    Abstract: A test method and apparatus for determining the content of carboxylic acid-based corrosion inhibitors in a coolant or heat exchange fluid. The amount of acidic reagent added to the coolant or fluid between two pH equilibrium points is measured to determine the amount of inhibitors. The refractive index can be measured to determine the amount of freezing point depressant.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: December 17, 2002
    Assignee: Texaco Inc.
    Inventors: Jean-Pierre Maes, Peter Roose, Filip Van Kenhove
  • Patent number: 6475438
    Abstract: A test method and apparatus for determining the content of carboxylic acid-based corrosion inhibitors in a coolant or heat exchange fluid. The amount of acidic reagent added to the coolant or fluid between two pH equilibrium points is measured to determine the amount of inhibitors. The refractive index can be measured to determine the amount of freezing point depressant.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: November 5, 2002
    Assignee: Texaco Inc.
    Inventors: Jean-Pierre Maes, Peter Roose, Filip Van Kenhove