Waveguides Patents (Class 422/82.11)
  • Patent number: 10260095
    Abstract: The invention relate to systems and methods for sequencing polynucleotides, as well as detecting reactions and binding events involving other biological molecules. The systems and methods may employ chamber-free devices and nanosensors to detect or characterize such reactions in high-throughput. Because the system in many embodiments is reusable, the system can be subject to more sophisticated and improved engineering, as compared to single use devices.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: April 16, 2019
    Assignee: GENAPSYS, INC.
    Inventors: Hesaam Esfandyarpour, Kosar Baghbani Parizi, Mark F. Oldham, Eric S. Nordman, Richard T. Reel, Susanne Baumhueter, Cheryl Heiner, Frank Lee
  • Patent number: 10088428
    Abstract: A surface refractive index acquisition system for characterization of a sample is provided. The system comprises a grating device configured to receive the sample, and first and second grating regions. First and second grating periods are selected to provide optical resonances for light respectively in first and second wavelength bands. A light source is configured to illuminate part of the first and second grating regions simultaneously. An imaging system is configured to image light from the grating device and comprises an optical element focusing light in a transverse direction and being invariant in an orthogonal transverse direction, the optical element being oriented such that the longitudinal direction of the grating device is oriented to coincide with the invariant direction of the optical element, and an imaging spectrometer comprising an entrance slit having a longitudinal direction oriented to coincide with the invariant direction of the optical element.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: October 2, 2018
    Assignee: Danmarks Tekniske Universitet
    Inventors: Anders Kristensen, Christoph Vannahme, Martin Dufva
  • Patent number: 10018566
    Abstract: Optical readers and alignment tools for detecting the level of an analyte. Described herein are small, disposable partially-encapsulated sensing chips for detecting an analyte level from a fluid sample (e.g., a blood sample) having an edge of the integrated sensing chip exposed to directly expose a plurality of excitation and a collection waveguides, as well as optical readers and methods of operating them. A fluid sample maybe applied to a sensing surface of the sensing chip in the housing so that an analyte level can be optically detected. Also described are methods of sensing an analyte using these devices and systems including an optical detector.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: July 10, 2018
    Assignee: LDIP, LLC
    Inventors: Ming Tan, Yun-Pei Chang, Leyla Sabet, Ashutosh Shastry, Christopher E. Todd, Reuven Duer
  • Patent number: 9976969
    Abstract: A method of evaluating a crystallized silicon layer on a substrate includes injecting light into the substrate in such a way that it is wave-guided by the substrate. Wave-guided injected light is diffracted out of the substrate by periodic features of the silicon layer. The diffracted light is detected and processed to evaluate the crystalline layer.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: May 22, 2018
    Assignee: Coherent LaserSystems GmbH & Co. KG
    Inventor: Paul Van Der Wilt
  • Patent number: 9878328
    Abstract: This describes an apparatus comprising a plate with a number of elements having a hydrophilic surface arranged in an array with an overlay having a hydrophobic surface. A height of the overlay is between about 5% and 100% of the diameter of the elements. The application also discloses a wall circumferential to the plate; and a removable grid insertable into the apparatus, said grid comprising dividers enclosing a number of through-holes, said through-holes spaced in the grid to allow alignment of the through-holes of the grid over the elements in the plate when said grid is inserted into the apparatus, said dividers of the grid inserted into the apparatus form sides of wells bottomed by the plate and at least one element on said plate.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: January 30, 2018
    Assignee: Curiox Biosystems Pte Ltd.
    Inventors: Namyong Kim, Siah Chong Cheong, Melvin Han Wen Lye, Mark Siew Peng Phong, Li Li, Teow Soon Seah
  • Patent number: 9829485
    Abstract: A biosensor device for detecting biological particles, the biosensor device comprising a substrate, a regular pattern of pores formed in the substrate, and a plurality of sensor active structures each of which being arranged on a surface of a corresponding one of the pores, wherein each of the plurality of sensor active structures is sensitive to specific biological particles and is adapted to modify electromagnetic radiation interaction properties in the event of the presence of the respective biological particles.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: November 28, 2017
    Assignee: NXP B.V.
    Inventors: Pablo Garcia Tello, Freddy Roozeboom
  • Patent number: 9354170
    Abstract: A method includes detecting D2O in a sample by fluorescence spectroscopy. The fluorescence spectroscopy may be near-infrared fluorescence spectroscopy. The method may include observing an excitation wavelength of the sample at 620 nm to 640 nm. The method may also include observing an emission wavelength of the sample at 900 nm to 1000 nm. The method includes detecting D2O and D2O nano-clusters and their alterations in presence of suspended or colloidal objects including bio-molecules or cells, by emission spectroscopy.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: May 31, 2016
    Assignee: UNIVERSITY OF CALCUTTA
    Inventors: Anjan Kr. Dasgupta, Hirak Kumar Patra
  • Patent number: 9274104
    Abstract: According to one embodiment, a measuring system using an optical waveguide is provided. The measuring system has an optical waveguide, magnetic fine particles, a magnetic field applying unit, a light source and a light receiving element. The optical waveguide has a sensing area to which first substances having a property of specifically bonding to subject substances to be measured are fixed. Second substances having a property of specifically bonding to the subject substances are fixed to the magnetic fine particle. The magnetic field applying unit generates a magnetic field for moving the magnetic fine particles. The light source inputs a light into the optical waveguide. The light receiving element receives the light output from the optical waveguide.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: March 1, 2016
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Ichiro Tono, Shingo Kasai, Takaaki Wada, Isao Nawata, Masaaki Hirakawa, Tomohiro Takase, Kayoko Oomiya, Takeshi Yamauchi, Tadahiro Nakayama, Isamu Nitta
  • Patent number: 9164026
    Abstract: Systems and methods for chip-integrated label-free detection and absorption spectroscopy with high throughput, sensitivity, and specificity are disclosed. The invention comprises packaged chips for multiplexing photonic crystal microcavity waveguide and photonic crystal slot waveguide devices. The packaged chips comprise crossing waveguides to prevent leakage of fluids from the microfluidic channels from the trenches or voids around the light guiding waveguides. Other embodiments are described and claimed.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: October 20, 2015
    Assignee: Omega Optics, Inc.
    Inventors: Swapnajit Chakravarty, Amir Hosseini, Ray T. Chen
  • Patent number: 9140652
    Abstract: Performing a measurement using an optical field enhancement device which includes a transparent substrate having a transparent fine uneven structure on a surface and a metal film formed on a surface of the fine uneven structure on the surface of the substrate, in which a subject is placed on the metal film of the optical field enhancement device, then excitation light is projected onto an area of the optical field enhancement device on which the subject is placed, and light generated by the projection of the excitation light is detected from a back surface side of the transparent substrate.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: September 22, 2015
    Assignee: FUJIFILM Corporation
    Inventors: Masayuki Naya, Shinya Hakuta
  • Patent number: 9063135
    Abstract: Systems and methods for chip-integrated label-free detection and absorption spectroscopy with high throughput, sensitivity, and specificity are disclosed. The invention comprises packaged chips for multiplexing photonic crystal waveguide and photonic crystal slot waveguide devices. Other embodiments are described and claimed.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: June 23, 2015
    Assignee: Omega Optics, Inc.
    Inventors: Swapnajit Chakravarty, Amir Hosseini, Ray T. Chen
  • Publication number: 20150140680
    Abstract: Disclosed is an integral label-free biosensor capable of analyzing a biomolecule with high sensitivity by integrating a light source, a photodetector, an optical waveguide, and a microcantilever on a substrate, and a method of detecting a bio-antigen by using the same. The integral label-free biosensor according to the present invention may be manufactured with low cost, be easily integrated with a silicon electron device, and detect a biomolecule with high sensitivity by using a label-free method.
    Type: Application
    Filed: October 24, 2014
    Publication date: May 21, 2015
    Inventors: Chul HUH, Sang Hyeob KIM, Byoung Jun PARK, Eun Hye JANG, Myung Ae CHUNG
  • Publication number: 20150140556
    Abstract: The present invention provides, in addition to other things, methods, systems, and apparatuses that involve the use of an optical fiber with grating and particulate coating that enables simultaneous heating; optical detection; and optionally temperature measurement. Methods, systems, and apparatuses of the present invention may be used in many applications including isothermal and/or thermal cycling reactions. In certain embodiments, the present invention provides methods, systems, and apparatuses for use in detecting, quantifying and/or identifying one or more known or unknown analytes in a sample.
    Type: Application
    Filed: June 20, 2013
    Publication date: May 21, 2015
    Inventors: Jacques Albert, Anatoli Ianoul, Aliaksandr Bialiayeu, Adam Bottomley
  • Patent number: 9028772
    Abstract: A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: May 12, 2015
    Assignee: Google Inc.
    Inventors: Huanfen Yao, Jeffrey George Linhardt, Babak Parviz
  • Patent number: 9023281
    Abstract: Chemical indicator apparatuses containing one or more chemical indicators for use in monitoring the quality of water in an aquatic environment. The apparatuses are designed and configured to be submersible in the water that is being monitored. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo a physical change as levels of one or more constituents of the water change. Such indicators can be read by one or more suitable optical readers. These and other embodiments are designed and configured to be movable by a corresponding monitoring/measuring apparatus, for example, via a magnetically coupled drive. Also disclosed are a variety of features that can be used to provide a chemical indicator apparatus with additional functionalities.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: May 5, 2015
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Publication number: 20150110676
    Abstract: Beginning with a sheet of optically transparent material, one may fabricate a great many shaped optical wafers, each in the form of a thin and essentially flat piece of optical material having a narrow cross-sectional width relative to length, and a sharply narrowed tip at one end. The fabrication process involves passing a sheet of optically transparent material through one or more operational steps wherein cutting, shearing, embossing, microperforating, or a combination thereof is performed. The fabrication process may further include a cladding operation, a tip texturing operation, and an analyte-reactive reagent deposition operation. The completed optical wafers are separated and each may be mounted into a user-operated device along with systems for educing a fluid sample to be expressed from a living organism, for bringing the tip of the optical wafer into contact with the fluid sample, and for illuminating and assaying the fluid sample.
    Type: Application
    Filed: October 18, 2013
    Publication date: April 23, 2015
    Inventor: Hiroshi Nomura
  • Patent number: 9012207
    Abstract: A biomolecular assay includes a substrate with a metallic layer on at least one surface thereof. The metallic film includes nanocavities. The nanocavities are configured to enhance signals that are representative of the presence or amount of one or more analytes in a sample or sample solution, and may be configured to enhance the signal by a factor of about two or more or by a factor of about three or more. Such signal enhancement may be achieved with nanocavities that are organized in an array, randomly positioned nanocavities, or nanocavities that are surrounded by increased surface area features, such as corrugation or patterning, or nanocavities that have quadrilateral or triangular shapes with tailored edge lengths, or with a plurality of nanoparticles. Methods for fabricating biomolecular substrates and assay techniques in which such biomolecular substrates are used are also disclosed.
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: April 21, 2015
    Assignee: University of Utah Research Foundation
    Inventors: Steven M. Blair, Farhad Mahdavi, Yongdong Liu, James N. Herron, Ajay Nahata
  • Publication number: 20150098866
    Abstract: An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide. The light guide test sensor is adapted to be used to test the level of an analyte in a biological fluid sample when used with a readhead. A method of manufacturing the light guide test sensor involves providing a plurality of light guides, providing a strip of reagent-coated membrane, and providing a strip of mesh layer. The reagent-coated membrane and mesh layer are attached to the light guides by ultrasonic welding. The reagent-coated membrane and mesh layer may also be attached to the light guides by adhesive.
    Type: Application
    Filed: December 15, 2014
    Publication date: April 9, 2015
    Inventors: Jeffery S. Reynolds, Steven C. Charlton, Sung-Kwon Jung, Suny J. George
  • Patent number: 8999264
    Abstract: A coating formula and method for surface coating non-porous surfaces. Microfluidic devices including said coating achieve desired properties including increased hydrophilicity, improved adhesion, stability and optical clarity.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: April 7, 2015
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael J. Pugia
  • Publication number: 20150093816
    Abstract: The present disclosure relates to a device for analyzing a fluid sample. In one aspect, the device includes a fluidic substrate that comprises a micro-fluidic component embedded in the fluidic substrate configured to propagate a fluid sample via capillary force through the device and a means for providing a fluid sample connected to the micro-fluidic component. The device also includes a lid attached to the fluidic substrate at least partly covering the fluidic substrate and at least partly closing the micro-fluidic component. The fluidic substrate may be a silicon fluidic substrate and the lid may be a CMOS chip. In another aspect, embodiments of the present disclosure relate to a method for fabricating such a device, and the method may include providing a fluidic substrate, providing a lid, and attaching, through a CMOS compatible bonding process, the fluidic substrate to the lid to close the fluidic substrate at least partly.
    Type: Application
    Filed: December 11, 2014
    Publication date: April 2, 2015
    Applicant: IMEC VZW
    Inventors: Liesbet Lagae, Peter Peumans
  • Patent number: 8992836
    Abstract: Embodiments of optofluidic devices or methods according to the application can provide on-chip, label-free, massively parallel analysis of analytes. An embodiment of the optofluidic device can comprise a microresonator, a waveguide optically coupled to the microresonator, and a fluidic channel that exposes an analyte to an evanescent field from the microresonator, wherein the light signal has a linewidth lesser than the width of at least one resonance of the light signal propagating in the microresonator. The light signal can be tuned across a spectrum of light wavelengths, wherein the spectrum of wavelengths includes one or more wavelengths defining the at least one resonance in the microresonator. The light transmission through the waveguide over the spectrum of wavelengths of the input light can be detected, and an absorption spectrum of the analyte can be determined.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: March 31, 2015
    Assignee: Cornell University
    Inventors: Arthur Nitkowski, Michal Lipson
  • Patent number: 8991238
    Abstract: The present invention relates to a portable digital reader for urinalysis. The portable digital reader for reading an analysis target chip including a plurality of test areas, comprises: a main body including a light emitting section having light emitting elements for radiating light, an integral optical splitter for uniformly distributing the light from the light emitting section to each test area of the analysis target chip, a light receiving section for receiving light reflected from the each test area so as to convert the same to electric signals, and a measuring section for measuring concentration according to the electric signals obtained from the light receiving section; a main supporting body having the analysis target chip and assembled with the main body; and an auxiliary supporting body assembled between the analysis target chip and the main supporting body, including a groove for assembling the analysis target chip, and assembled with the main supporting body to be exchanged after use.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: March 31, 2015
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Dae Sik Lee, Hyun Woo Song, Byoung Goo Jeon, Min Joon Kim, Moon Youn Jung, Seon Hee Park
  • Patent number: 8994946
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 31, 2015
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena
  • Patent number: 8992860
    Abstract: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: March 31, 2015
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Brian Murphy, Scott Corey, Alex Flamm, Ben Lane, Conrad Laskowski, Chad Schneider
  • Patent number: 8974751
    Abstract: Sample liquid is collected in a chamber downstream of a separating device. Adjoining the chamber are a plurality of channels which guide the sample liquid to one or more investigating regions.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: March 10, 2015
    Assignee: Boehringer Ingelheim Microparts GmbH
    Inventors: Tobias Rodenfels, Gert Blankenstein
  • Patent number: 8968677
    Abstract: An improved apparatus and method for dispersion of a labeling conjugate in a diagnostic assay, the result being a one-step assay. By eliminating a conjugate pad as in conventional lateral diagnostic devices, and forming a frazil ice pellicle (FIP), rehydration and flow are improved resulting in better reproducibility, improved sensitivity, and reduced costs of individual assay devices. The formation of a frazil ice film formed on a super cooled surface of a sample receiving means simplifies assay assembly. Lyophilization of the FIP improves the release of a sample/analyte/label matrix into a macro channel as in a direct flow assay, while at the same time allowing reagents to mix and flow, thereby optimizing the assay performance. The reagents of the conjugate and the formation of the FIP stabilize the conjugate proteins and provide extended shelf life to the diagnostic assay device.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: March 3, 2015
    Assignee: Quantum Design International, Inc.
    Inventors: Ronald T. LaBorde, Nicholas J. Neild
  • Patent number: 8961898
    Abstract: The present invention provides a bilayer membrane produced using a microchannel capable of easily forming bilayer membranes such as planar lipid bilayer membranes in large quantities, and a production method thereof. A process for producing a bilayer membrane of the present invention comprises forming a state where two liquid phases or liquid and gaseous phases each containing amphipathic molecules are alternately arranged in a microchannel, discharging one of the two liquid phases or the gaseous phase of the liquid and gaseous phases through branch minichannels formed in the wall on one side or in the walls on both sides to contact the remaining liquid phases adjacent to each other, and thereby forming a side-by-side arrangement of bilayer membranes comprising the amphipathic molecules.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: February 24, 2015
    Assignee: Tokyo Institute of Technology
    Inventors: Takasi Nisisako, Takahiro Baba
  • Patent number: 8951474
    Abstract: The present invention provides an apparatus for analyzing particles in a solution including a unit configured to place a flow cell having a flow path for flowing a sample solution containing the particles; a unit configured to illuminate the sample solution flowing through the flow path of the flow cell; a photodetector that detects a scattered light and/or fluorescence generated from the particles in the sample solution; and a unit configured to analyze the particles based on their signal intensities detected by the photodetector, wherein the flow cell has the flow path formed in a substrate, a reflection plane is formed on the side surface of the flow path, the reflection plane leads the lights generated in the flow path of the flow cell and advancing in the substrate in-plane direction to a specified region of the surface of the flow cell, and the photodetector detects the light exiting from the specified region to the outside.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: February 10, 2015
    Assignee: On-Chip Biotechnologies Co., Ltd.
    Inventor: Kazuo Takeda
  • Patent number: 8945472
    Abstract: The present invention provides a biosensor system comprising a light source, a cartridge adapted to be illuminated by said light source, a light detector adapted for detecting a signal originating from the cartridge, an illumination control means adapted to vary the illumination of the cartridge between at least two different states, a means for generating a first oscillation with a first frequency, and a means for generating a second oscillation with a second frequency, wherein the frame rate of the light detector is triggered by the first oscillation and the illumination control means is triggered by the second oscillation.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: February 3, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Josephus Arnoldus Henricus Maria Kahlman, Bart Michiels
  • Patent number: 8945939
    Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: February 3, 2015
    Assignee: Ecolab USA Inc.
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert Mack
  • Patent number: 8940523
    Abstract: The present invention relates to a pipette tip (100, 200, 201, 300) comprising a tip body (110) having an inner surface and an outer surface (112). The inner surface (111) defines an inner cavity (120, 320), which has an upper end and a lower end. The upper end has an upper opening (131); and the lower end has a lower opening (141). At least a part of the inner surface (111) is provided with capturing agents (151) of at least one type forming at least one capturing-agent region (150) on the at least one inner surface. The at least one capturing agent region (150) is capable of selectively binding target substances (152) of at least one type comprised in a sample to form at least agent-target conjugates (155), the arrangement of which define at least one agent-target region (156).
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: January 27, 2015
    Assignee: CSEM Centre Suisse d'Electronique et de Microtechnique S.A.—Recherche et Developpement
    Inventors: Stéphane Follonier, Linsey Fan, Pierre Indermuhle
  • Patent number: 8940237
    Abstract: An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide. The light guide test sensor is adapted to be used to test the level of an analyte in a biological fluid sample when used with a readhead. A method of manufacturing the light guide test sensor involves providing a plurality of light guides, providing a strip of reagent-coated membrane, and providing a strip of mesh layer. The reagent-coated membrane and mesh layer are attached to the light guides by ultrasonic welding. The reagent-coated membrane and mesh layer may also be attached to the light guides by adhesive.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: January 27, 2015
    Assignee: Bayer HealthCare LLC
    Inventors: Jeffery S. Reynolds, Steven C. Charlton, Sung-Kwon Jung, Suny J. George
  • Patent number: 8940238
    Abstract: The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: January 27, 2015
    Assignee: Access Medical Systems, Ltd.
    Inventors: Hong Tan, Yushan Tan, Erhua Cao, Ming Xia, Robert F. Zuk
  • Patent number: 8940234
    Abstract: Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: January 27, 2015
    Assignee: Intel Corporation
    Inventors: Yuegang Zhang, Andrew A. Berlin, Qing Ma, Li-Peng Wang, Valluri Rao, Mineo Yamakawa
  • Publication number: 20150023840
    Abstract: The disclosed subject matter provides a nanoaperture having a bottom surface and a side wall comprising gold. A surface of the side wall is passivated with a first functional molecule comprising polyethylene glycol. The bottom surface of the nanoaperture can be functionalized with at least one second molecule comprising polyethylene glycol, for example, a silane-PEG molecule. The second molecule can further include a moiety, such as biotin, which is capable of binding a target biomolecule, which in turn can bind to a biomolecule of interest for single molecule fluorescence imaging analysis. Fabrication techniques of the nanoaperture are also provided.
    Type: Application
    Filed: July 28, 2014
    Publication date: January 22, 2015
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Colin Kinz-Thompson, Ruben L. Gonzalez, JR., James C. Hone, Matteo Palma, Alexander Alexeevich Godarenko, Daniel Alexandre Chenet, Shalom J. Wind
  • Patent number: 8932874
    Abstract: The invention is directed towards methods and compositions for identifying the amount of ammonium acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of ammonium acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of ammonium acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the ammonium acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: January 13, 2015
    Assignee: Nalco Company
    Inventors: Amy M. Tseng, Brian V. Jenkins, Robert M. Mack
  • Patent number: 8920749
    Abstract: A microchip capable of sending liquid in a micro flow channel to a predetermined place irrespective of the pressure difference and sending a mixture of two or more liquid masses to a predetermined place even if the channel structure is simple. The microchip comprises an intermediate reservoir portion provided in a micro flow channel and adapted for temporarily holding liquid sent through the micro flow channel. The microchip is characterized in that the intermediate reservoir portion has a side channel, the volume of the intermediate reservoir portion is smaller than the total volume of the liquid sent into the intermediate reservoir portion, the side channel is provided for communication of a micro flow channel on the upstream side of the intermediate reservoir portion with a micro flow channel on the downstream side thereof, and the cross-section area of the side channel is smaller than that of the micro flow channel.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: December 30, 2014
    Assignee: Konica Minolta Medical & Graphic, Inc.
    Inventors: Youichi Aoki, Akihisa Nakajima, Kusunoki Higashino, Yasuhiro Sando, Yoshikazu Kurihara
  • Patent number: 8920729
    Abstract: A sensor for sensing at least one biological target or chemical target is provided. The sensor includes a membrane includes a membrane material that supports generation and propagation of at least one waveguide mode, where the membrane material includes a plurality of voids having an average size <2 microns. The sensor also includes at least one receptor having structure for binding to the target within the plurality of voids, and an optical coupler for coupling light to the membrane sufficient to generate the waveguide mode in the membrane from photons incident on the optical coupler.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: December 30, 2014
    Assignee: Vanderbilt University
    Inventors: Guoguang Rong, Sharon M. Weiss, Raymond L. Mernaugh
  • Patent number: 8920723
    Abstract: A sample support structure comprising a sample support manufactured from a semiconductor material and having one or more openings therein. Methods of making and using the sample support structure.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: December 30, 2014
    Assignee: Protochips, Inc.
    Inventors: John Damiano, Jr., Stephen E. Mick, David P. Nackashi
  • Patent number: 8906670
    Abstract: The application relates to improved optical containment structures, methods of manufacture and use, and systems for employing same. The optical containment structures generally comprise zero-mode waveguide structures having non-reflective walls. The non-reflective walls allow the preparation of optical containment regions in which the optical containment dimensions can be decoupled from the solution containment dimensions. The application also relates to methods for producing islands of functionality within nanoscale apertures.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: December 9, 2014
    Assignee: Pacific Bioscience of California, Inc.
    Inventors: Jeremy Gray, Ronald L. Cicero, Annette Grot, Natasha Popovich, Stephen Dudek
  • Patent number: 8906672
    Abstract: A single injection gradient with a biosensor, both structural and methodological, achieves the binding of analyte to immobilized ligand over a wide concentration range without the necessity of regeneration of the sensing area. A gradient of concentrations adjacent to or within a flow cell facilitates kinetic analysis of interactions without requiring multiple discrete volumes or injections to achieve a range of concentrations. A continuous gradient fluid is preferably formed directly adjacent to the flow cell inlet or a region of sample/buffer dispersion at an injection point into a flow channel of a flow cell. The analyte gradient may be flowed through the flow cell from a low analyte concentration. Multiple component gradients are also provided.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: December 9, 2014
    Assignee: Flir Systems, Inc.
    Inventor: John Gerard Quinn
  • Patent number: 8900515
    Abstract: The present invention provides a biosensing device, comprising an input unit, an analysis unit, a process unit, and a set unit for storing resulting data values as the basis for calibrating the biosensing device, to set up the calibration parameters of a strip of the biosensing device.
    Type: Grant
    Filed: November 25, 2011
    Date of Patent: December 2, 2014
    Assignee: Health & Life Co., Ltd.
    Inventor: Meng Yi Lin
  • Patent number: 8894934
    Abstract: Techniques, apparatus, material and systems are described for implementing a three-dimensional composite mushroom-like metallodielectric nanostructure. In one aspect, a surface plasmon based sensing device includes a substrate and a layer of an anti-reflective coating over the substrate. The surface Plasmon based sensing device includes a dielectric material on the anti-reflective coating shaped to form a 2-dimensional array of nanoholes spaced from one another. Also, the surface Plasmon based sensing device includes a layer of a metallic film formed on the 2-dimensional array of nanoholes to include openings over the nanoholes, respectively, wherein the sensing device is structured to support both propagating surface plasmon polariton (SPP) waves and localized surface plasmon resonant (LSPR) modes.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: November 25, 2014
    Assignee: The Regents of the University of California
    Inventors: Lin Pang, Haiping Matthew Chen, Yeshaiahu Fainman
  • Patent number: 8883079
    Abstract: A water-quality monitoring system for an aquatic environment that includes a monitoring unit and a chemical indicator wheel designed and configured to be submerged in the water being monitored. The chemical indicator wheel includes a holder that supports a number of chemical indicators selected for use in measuring levels of constituents of the water. When in use, the wheel is drivingly engaged with a monitoring/measuring unit that includes at least one reader for reading the chemical indicators. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo an optically detectable physical change as levels of one or more constituents of the water change. Also disclosed are a variety of features that can be used to provide the monitoring system with additional functionalities.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: November 11, 2014
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Patent number: 8883080
    Abstract: A device, a method of fabricating the device and a sample analysis system that includes the device are provided. The device includes an optical waveguide having a plurality of nanofeatures integrated thereon to influence at least one of evanescence and coupling of an optical field of the optical waveguide. The sample analysis system includes a fluidic actuation system for introducing sample specimen fluid into a microfluidic channel of the device for evanescence based detection.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: November 11, 2014
    Assignee: Concordia University
    Inventors: Muthukumaran Packirisamy, Arvind Chandrasekaran
  • Patent number: 8877129
    Abstract: The invention relates to a device for optical detection of substances in a liquid or gaseous medium, with a substrate with molecules for detecting the substances that are to be detected, wherein these molecules are immobilized at a surface of the substrate or in the substrate and wherein the substances that are to be detected can essentially be selectively bound to these molecules, wherein light waves can be coupled into the substrate and can be guided through this, and wherein the substrate is a foil element made of a transparent material in which a coupling structure for coupling the light waves is integrally formed and in which the coupled light waves can be guided.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: November 4, 2014
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.
    Inventor: Albrecht Brandenburg
  • Patent number: 8871148
    Abstract: Herein are disclosed methods and devices for detecting the presence of an analyte. Such methods and devices may comprise at least one sensing element that comprises at least one optically responsive layer that comprises at least a highly analyte-responsive sublayer and a minimally analyte-responsive sublayer. Methods of making and using such sensing elements are also disclosed.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: October 28, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Michael S. Wendland, Neal A. Rakow
  • Patent number: 8865078
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: October 21, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu
  • Patent number: 8867038
    Abstract: An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: October 21, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Nathaniel Joseph McCaffrey, Stephen Turner, Ravi Saxena, Scott Edward Helgesen
  • Patent number: 8865077
    Abstract: An apparatus for detecting an object capable of emitting light. The apparatus comprises a light source and a waveguide. The waveguide comprises a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further comprises a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: October 21, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chung-Fan Chiou, Rung-Ywan Tsai, Yu-Tang Li, Chih-Tsung Shih, Ming-Chia Li, Chang-Sheng Chu, Shuang-Chao Chung, Jung-Po Chen, Ying-Chih Pu