Abstract: A new antibiotic SF-1130-x.sub.3 substance is produced by cultivating a microorganism Streptomyces myxogenes SF-1130 (deposited under FERM-P. 676 and ATCC 31305) in a liquid culture medium under aerobic conditions, and this antibiotic may be isolated from the fermentation broth of said microorganism and is useful as an inhibitor to .alpha.-glucosidase and saccharase. Besides, this antibiotic, when orally given, is useful as a drug for suppressing an elevation in the level of blood sugar in living animals which have taken starch and/or sugars.

Abstract: Novel antibiotic U-60, 394 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces woolenses, Dietz and Li sp.n., NRRL 12113. This antibiotic is strongly active against various Gram-positive bacteria, for example, Staphylococcus aureus and Streptococcus hemolyticus. It is also strongly active against the Gram-negative bacterium Streptococcus pneumoniae. Thus, antibiotic U-60, 394 can be used in various environments to eradicate or control such bacteria.

Abstract: A method of treating inflammation comprising topical administration to mammals suffering from an inflammatory condition not associated with amicrobial component, employing selected antibiotics as the anti-inflammatory agent.

Abstract: A novel antibiotic designated BN-183B substance is disclosed which is produced by cultivating a strain of the genus Pseudomonas. The antibiotic has a strong action against Gram-positive and Gram-negative bacteria.

Abstract: Macromolecular reconstituted collagen is prepared by treating natural insoluble collagen with an aqueous solution comprised of an alkali sulfate salt and an alkali metal hydroxide for at least 48 hours to saponify fats suspended within the natural insoluble collagen. The fat free collagen is then treated with an aqueous solution comprised of an alkali metal sulfate for at least four hours to stabilize the interfibular bonds between individual polypeptide chains. The collagen is then dissolved in an aqueous acid solution and frozen at a rate of -20.degree. C./hour. The frozen collagen is vacuum dried at 10.sup.-3 to 10.sup.-5 torr for at least 16 hours to produce a biologically active collagen article. Various biologically active materials may be added to the aqueous acid solution prior to freezing. The collagen product may then be implanted into an animal or the like and the medication slowly released.

Abstract: KS-2-B was obtained as purified material from the culture of Daedalea dickinsii KSDD 6 (FERM-P No. 3993), Lentinus edodes KSLE 7 (FERM-P No. 3994) or Lentinus edodes KSLE 28 (FERM-P No. 4196). This substance, KS-2-B, is an effective interferon inducing substance.

Abstract: New antibiotic, SF-2052 substance is produced by cultivating a microorganism, Dactylosporangium matsuzakiense SF-2052 now deposited under FERM-P 4670 or ATCC No. 31570 in a liquid culture medium under aerobic conditions, and this antibiotic may be isolated from the culture broth by conventional method and is useful as antibacterial agent.

Abstract: An anti-tumor substance which is not only heatstable but also has low inflaming and pain-inducing properties and low pyrogenic activity is disclosed. The substance is prepared by disrupting cells of bacteria belonging to hemolytic streptococci, extracting from the disrupted material a water-insoluble substance and treating the substance with one or more proteases and, optionally, with one or more nucleases.

Abstract: A novel product comprising nitrogen-containing polysaccharides is produced by bringing a culture product of fungi Basidiomycetes into reaction with an aqueous ammoniacal solution at a temperature of 100.degree. to 250.degree. C. The product is remarkably effective in controlling various plant viruses.

Abstract: The antibacterial compound S551-II (Reductiomycin) is produced by culturing a microorganism belonging to the genus Streptomyces.S551-II-A is prepared by sublimation of the compound S551-II.

Abstract: Antitumor substances are prepared by culturing a microorganism, Acinetobacter calcoaceticus. The antitumor substances have potent antitumor activity as well as immunostimulatory activity and are effective in a very small amount without harmful effects such as toxicity.

Abstract: Antimicrobial compositions are provided wherein there is obtained an enhancement of the activity of an antimicrobial agent exemplified by quaternary ammonium compounds, bisdiguanides, anti-fungal agents, phenols, hydroxydiphenyls, carbanilides, salicylanilides, organo-metallic antiseptics, antibiotics, halogens, organic halogen derivatives and iodophores derived from nonionic surface active agents and from polyvinylpyrrolidone by combining the antimicrobial agent with an effective amount of a potentiator.

Abstract: Novel oligosaccharide substances, TAI-A and TAI-B, possessing a strong inhibitory activity to amylase and invertase are obtained by inoculating a seed of the strain of Streptomyces calvus TM-521 into aqueous nutrient medium, cultivating this with shaking or by a submerged culture method with aeration, and separating the produced amylase inhibitors TAI-A and TAI-B from the cultured broth.

Abstract: KS-substance was obtained as raw material from the cultured mycelium of Daedalea dickinsii KSDD 6 (FERM-P No. 3993), Lentinus edodes KSLE 7 (FERM-P No. 3994) or Lentinus edodes KSLE 28 (FERM-P No. 4196), and by refining this substance a novel substance KS-2-A was obtained. This substance KS-2-A and also the KS-substance as the raw material both enhance the host defense function of the living body.

Abstract: New antibiotics SF-1130-x.sub.1 substance and SF-1130-x.sub.2 substance are produced by cultivating a microorganism Streptomyces myxogenes SF-1130 now deposited under FERM-P. 676 and ATCC. 31305 in a liquid culture medium under aerobic conditions, and these antibiotics may be isolated from the fermentation broth and are useful as an activator for enhancing the host defense system in living animals. The activity of these antibiotics may be improved when used in combination with one or more of maltose, maltotriose, maltotetraose, maltopentaose, maltohexaose and maltoheptaose.

Abstract: The invention provides a synergistic composition of a polyether antibiotic and a pleuromutilin derivative, which has an enhanced effect against coccidiosis in poultry. The composition may be prepared in the form of a premix concentrate and incorporated into commercial complete poultry feed. A method of treatment or prophylaxis of coccidiosis in poultry by co-administration of the components is also claimed.

Abstract: A novel antibiotic sporamycin has both anti-transplanted tumor and antibacterial activity and is produced by culturing a microorganism of the genus Streptosporangium, particularly Streptosporangium pseudovulgare PO-357 FERM-P No. 3571, ATCC No. 31308.

Abstract: Bloat, particularly feedlot bloat, in ruminants is treated and controlled by the administration of the antibiotic S 15-1. This antibiotic can also be employed to lessen digestive disturbances caused when the diet of the ruminant is changed.

Abstract: Novel procidins effective for healing or preventing ulcer are produced and accumulated in the cultured product of a novel strain Streptomyces procidinanus.

Abstract: There is disclosed a new antibiotic A21A which is produced by cultivating the microorganism, Streptomyces filipinensis, in aqueous nutrient medium. The antibiotic has growth-improving activity.

Abstract: A prolonged release drug dosage form for the treatment of bovine mastitis, specifically suited for dry cow treatment, consists of an antimicrobial agent dispersed in a matrix of a low molecular weight polyester of glycolic and lactic acids, and shaped as a cylindrical bougie for facile insertion into the teat canal. Said polyester erodes by hydrolysis in the bioenvironment, providing a continuous release of the medication throughout the desired duration of the treatment. The low molecular weight polyesters have a glycolic acid content of about 60 to 80 mole percent, a lactic acid content of about 20 to 40 mole percent, and a molecular weight less than 2000.

Abstract: A novel antibiotic B-98891, which is produced by culturing a strain of microorganisms belonging to the genus Streptomyces, shows remarkable combatting effect against microorganisms causing plant diseases. Compositions containing the antibiotic are useful for controlling diseases in plants with less undesirable side effects.

Abstract: Disclosed is a new antibiotic, Compound 41,012, which is produced by the submerged aerobic fermentation of a new species of Actinoplanes designated Actinoplanes nipponensis sp. nov. Routien, ATCC 31145. Methods for the recovery and purification of Compound 41,012 are also described as are some of its antimicrobial properties.

Abstract: Tissue in warm blooded animals which is damaged and/or infected is treated by administering a therapeutically effective amount of a novel catalyst or synergist. The treatment is effective in relieving stress and/or shock. In a further variant warm blooded animals having damaged and/or infected tissue are treated with a composition containing a therapeutically effective amount of at least one antibiotic and the catalyst or synergist. Novel therapeutic compositions are provided which contain at least one antibiotic and an effective amount of the catalyst or synergist.

Abstract: A new antibiotic complex, complex 484, components 484-A and 484-B thereof and a process for their preparation are disclosed. These antibiotic substances are producible by culturing a microorganism of the species Streptomyces in an aqueous nutrient medium under submerged aerobic fermentation conditions. The substances are useful against a broad spectrum of pathogenic bacteria. Methods for their use are disclosed also.

Abstract: The antibiotics LL-AC541 and racemomycin A both members of the streptothricin family are useful as taeniacidal agents.

Abstract: This disclosure describes a novel series of active antibacterial agents derived by reaction of antibiotic AV290 with certain classes of alkyl halides.